The emergence of a novel coronavirus (SARS-CoV-2), their biology and therapeutic options


The new decade of the 21 st century (2020) started with the emergence of novel coronavirus known as SARS-CoV-2 that caused an epidemic of coronavirus disease (COVID-19) in Wuhan, China. It is the third highly pathogenic and transmissible coronavirus after severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in humans. The source of origin, transmission to humans and mechanisms associated with the pathogenicity of SARS-CoV-2 are not clear yet, however, its resemblance with SARS-CoV and several other bat coronaviruses was recently confirmed through genome sequencing related studies. The development of therapeutic strategies is necessary in order to prevent further epidemics and cure infected people. In this Review, we summarize current information about the emergence, origin, diversity, and epidemiology of three pathogenic coronaviruses with a specific focus on the current outbreak in Wuhan, China. Furthermore, we discuss the clinical features and potential therapeutic options that may be effective against SARS-CoV-2.


DOI: 10.1128/JCM.00187-20

Projects: COVID-19 Disease Map

Publication type: Journal

Journal: Journal of Clinical Microbiology

Citation: J Clin Microbiol,JCM.00187-20

Date Published: 11th Mar 2020


Registered Mode: imported from a bibtex file

Authors: Suliman Khan, Rabeea Siddique, Muhammad Adnan Shereen, Ashaq Ali, Jianbo Liu, Qian Bai, Nadia Bashir, Mengzhou Xue

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Khan, S., Siddique, R., Shereen, M. A., Ali, A., Liu, J., Bai, Q., Bashir, N., & Xue, M. (2020). Emergence of a Novel Coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2: Biology and Therapeutic Options. In C. S. Kraft (Ed.), Journal of Clinical Microbiology (Vol. 58, Issue 5). American Society for Microbiology.

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Created: 8th Apr 2020 at 22:13

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