Emodin inhibits current through SARS-associated coronavirus 3a protein
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BiBTeXThe open-reading-frame 3a of SARS coronavirus (SARS-CoV) had been demonstrated previously to form a cation-selective channel that may become expressed in the infected cell and is then involved in virus release. Drugs that inhibit the ion channel formed by the 3a protein can be expected to inhibit virus release, and would be a source for the development of novel therapeutic agents. Here we demonstrate that emodin can inhibit the 3a ion channel of coronavirus SARS-CoV and HCoV-OC43 as well as virus release from HCoV-OC43 with a K1/2 value of about 20 M. We suggest that viral ion channels, in general, may be a good target for the development of antiviral agents.
SEEK ID: https://fairdomhub.org/publications/497
DOI: 10.1016/j.antiviral.2011.02.008
Projects: COVID-19 Disease Map
Publication type: Journal
Journal: Antiviral Research
Citation: Antiviral Research 90(1):64-69
Date Published: 1st Apr 2011
URL: https://linkinghub.elsevier.com/retrieve/pii/S0166354211000465
Registered Mode: imported from a bibtex file
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Created: 8th Apr 2020 at 20:13
Last updated: 8th Dec 2022 at 17:26
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Projects: FAIRDOM, GMDS Project Group "FAIRe Dateninfrastrukturen für die Biomedizinische Informatik", COVID-19 Disease Map, COVID-19 related studies and tools in Germany, nfdi4health - German National Research Data Infrastructure for Personal Health Data, LiSyM Core Infrastructure and Management (LiSyM-PD), ModeleXchange initiative, SDBV/HITS, EDITH (Ecosystem Digital Twins in Health) test project
Institutions: Heidelberg Institute for Theoretical Studies (HITS gGmbH)
https://orcid.org/0000-0002-8318-3222
The Disease Maps Project is designed as a large-scale community effort. It is a network of groups that work together in order to better understand disease mechanisms. The project exchanges best practices, share information, develop tools to make it easier for all the involved groups to achieve their goals.
Projects: COVID-19 Disease Map
Web page: https://disease-maps.org
Here we share resources and best practices to develop a disease map for COVID-19. The project is progressing as a broad community-driven effort. We aim to establish a knowledge repository on virus-host interaction mechanisms specific to the SARS-CoV-2. The COVID-19 Disease Map is an assembly of molecular interaction diagrams established based on literature evidence.
Programme: Disease Maps
Public web page: http://doi.org/10.17881/covid19-disease-map
