Therapeutic Approaches for COVID-19 Based on the Dynamics of Interferon-mediated Immune Responses

Abstract:

As the outbreak of COVID-19 has accelerated, an urgent need for finding strategies to combat the virus is growing. Thus, gaining more knowledge on the pathogenicity mechanism of SARS-CoV2, the causing agent of COVID-19, and its interaction with the immune system is of utmost importance. Although this novel virus is not well known yet, its structural and genetic similarity with SARS-CoV as well as the comparable pattern of age-mortality relations suggest that the previous findings on SARS can be applicable for COVID-19. Therefore, a systems biology study was conducted to investigate the underlying mechanism for the differences in the age-specific mortality of SARS and the most important signaling pathways activated by the virus. The results were then validated through a literature review on COVID-19 and the other closely related viruses, SARS and MERS.

Citation: [Preprint]

Date Published: 12th Mar 2020

URL: https://www.preprints.org/manuscript/202003.0206/v1

Registered Mode: imported from a bibtex file

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Citation
Shahabi nezhad, F., Mosaddeghi, P., Negahdaripour, M., Dehghani, Z., Farahmandnejad, M., Moghadami, M., Nezafat, N., & Masoompour, S. M. (2020). Therapeutic Approaches for COVID-19 Based on the Dynamics of Interferon-mediated Immune Responses. In []. MDPI AG. https://doi.org/10.20944/preprints202003.0206.v1
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Created: 8th Apr 2020 at 22:13

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