The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade

Abstract:

In 2019, a new coronavirus (2019-nCoV) infecting Humans has emerged in Wuhan, China. Its genome has been sequenced and the genomic information promptly released. Despite a high similarity with the genome sequence of SARS-CoV and SARS-like CoVs, we identified a peculiar furin-like cleavage site in the Spike protein of the 2019-nCoV, lacking in the other SARS-like CoVs. In this article, we discuss the possible functional consequences of this cleavage site in the viral cycle, pathogenicity and its potential implication in the development of antivirals.

SEEK ID: https://fairdomhub.org/publications/468

DOI: 10.1016/j.antiviral.2020.104742

Projects: COVID-19 Disease Map

Publication type: Journal

Journal: Antiviral Research

Citation: Antiviral Research 176:104742

Date Published: 1st Apr 2020

URL: https://linkinghub.elsevier.com/retrieve/pii/S0166354220300528

Registered Mode: imported from a bibtex file

Authors: B. Coutard, C. Valle, X. de Lamballerie, B. Canard, N.G. Seidah, E. Decroly

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Coutard, B., Valle, C., de Lamballerie, X., Canard, B., Seidah, N. G., & Decroly, E. (2020). The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade. Antiviral Research, 176, 104742. https://doi.org/10.1016/j.antiviral.2020.104742
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Created: 8th Apr 2020 at 22:13

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