In 2019, a new coronavirus (2019-nCoV) infecting Humans has emerged in Wuhan, China. Its genome has been sequenced and the genomic information promptly released. Despite a high similarity with the genome sequence of SARS-CoV and SARS-like CoVs, we identiﬁed a peculiar furin-like cleavage site in the Spike protein of the 2019-nCoV, lacking in the other SARS-like CoVs. In this article, we discuss the possible functional consequences of this cleavage site in the viral cycle, pathogenicity and its potential implication in the development of antivirals.
Projects: COVID-19 Disease Map
Publication type: Journal
Journal: Antiviral Research
Citation: Antiviral Research 176:104742
Date Published: 1st Apr 2020
Registered Mode: imported from a bibtex file
Created: 8th Apr 2020 at 22:13