Studies

3 Studies visible to you, out of a total of 3

Core model predicting combined mutations and perturbations

MycoSynVac - Engineering Mycoplasma pneumoniae as a broad-spectrum animal vaccine

Predictions made using the core model for combinatorial perturbations to the model simulating combined effects from OE, KO mutants, perturbations and time series concentrations.

Submitter: Niels Zondervan

Investigation: Modelling of M. pneumoniae metabolism

Assays: 40 samples, OE mutants of glycolysis and pyruvate metabolism enzymes com...

Snapshots: No snapshots

Created: 1st May 2017 at 10:18, Last updated: 20th Nov 2019 at 23:19

Core Model training

MycoSynVac - Engineering Mycoplasma pneumoniae as a broad-spectrum animal vaccine

Training of the core model, parameter estimation using Evolutionary Programming using metabolomics, proteomics and some flux data. The core model contains reactions in glycolysis, pyruvate metabolism and ATPase

Submitter: Niels Zondervan

Investigation: Modelling of M. pneumoniae metabolism

Assays: Comparison of Kcat values from the model and values from literature, Construction and training of the core model

Snapshots: No snapshots

Created: 19th Apr 2017 at 07:48, Last updated: 20th Nov 2019 at 23:19

Core Model predictions

MycoSynVac - Engineering Mycoplasma pneumoniae as a broad-spectrum animal vaccine

Validation of the core model of glycolysis, pyruvate metabolism and ATPase reaction using OE, KO mutant samples and perturbation samples

Submitter: Niels Zondervan

Investigation: Modelling of M. pneumoniae metabolism

Assays: Dynamic model simmulation pipeline, Metabolic control analysis (local and global), Validation by simulating independent mutant and perturbation samples

Snapshots: No snapshots

Created: 19th Apr 2017 at 07:57, Last updated: 20th Nov 2019 at 23:19

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