Multiple sequence alignment of selected alpha-tubulins from dinitroaniline-sensitive and -resistant species Version 1
Clustal Omega multiple sequence alignment result for selected alpha-tubulins in FASTA format with gaps. Species and corresponding Uniprot identifiers can be found in the FASTA file.
The following species (Uniprot ID, dinitroaniline-sensitive/resistant) were considered:
- Trypanosoma cruzi (Q27352, sensitive)
- Trypanosoma brucei brucei (Q4GYY5, sensitive)
- Leishmania infantum (E9AGJ8, sensitive)
- Leishmania donovani (I3W8N6, sensitive)
- Leishmania major (Q4QGC5, sensitive)
- Toxoplasma gondii (P10873, sensitive)
- Plasmodium falciparum (P14642, sensitive)
- Eleusine indica (O22347, sensitive)
- Chlamydomonas reinhardtii (P09204, sensitive)
- Setaria viridis (Q65C79, sensitive)
- Zea mays (P14640, sensitive)
- Tetrahymena thermophila (P41351, sensitive)
- Homo sapiens (Q71U36, resistant)
- Bos taurus (Q32KN8, resistant)
- Sus scrofa (P02550, resistant)
- Sus barbatus (A0A0R4I993, resistant)
- Ovis aries (D0VWZ0, resistant)
- Rattus norvegicus (P68370, resistant)
- Gallus gallus (P08070, resistant)
- Saccharomyces cerevisiae (P09733, unknown)
SEEK ID: https://fairdomhub.org/data_files/6318?version=1
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alpha-tubulin_msa-clustalomega.fasta
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Created: 16th Feb 2023 at 15:01
Last updated: 24th Apr 2023 at 13:34
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Version 1 (earliest) Created 16th Feb 2023 at 15:01 by Ina Poehner
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Projects: Kinetics on the move - Workshop 2016, COVID-19 Disease Map, NMTrypI - New Medicines for Trypanosomatidic Infections, CoVIDD - Coronavirus interactions in drug discovery - optimization and implementation
Institutions: Kinetics on the move Workshop at HITS, Heidelberg Institute for Theoretical Studies (HITS gGmbH), University of Eastern Finland (UEF)
https://orcid.org/0000-0002-2801-8902
Group Leader, Molecular and Cellular Modeling Group, EML Research, Heidelberg
Projects: NMTrypI - New Medicines for Trypanosomatidic Infections
Web page: https://cordis.europa.eu/programme/id/FP7_HEALTH.2013.2.3.4-2
The New Medicines for Trypanosomatidic Infections - NMTrypI project aimed at obtaining new candidate drugs against Trypanosomatidic infections with appropriate efficiency from the lead phase to the final preclinical phase that are more accessible to patients.
Programme: Drug development for neglected parasitic diseases
Public web page: https://fp7-nmtrypi.eu/
Start date: 1st Feb 2014
End date: 31st Jan 2017
Design, synthesis, computational studies and biological evaluation of antiparasitic dinitroaniline-ether phospholipid hybrids
Submitter: Ina Poehner
Studies: Computational identification of potential dinitroaniline binding sites i..., Docking studies of trifluraline and the dinitroaniline-etherphospholipid...
Assays: Comparative electrostatic analysis of dinitroaniline-sensitive and -resi..., Induced-fit docking studies, Multiple sequence alignment, Preparation of multimeric tubulin docking receptors
Sequence and electrostatic potential analyses to identify sites in tubulins that differ between dinitroaniline-sensitive and dinitroaniline-resistant species.
Alignments of various alpha-tubulin and beta-tubulin sequences from dinitroaniline-sensitive and dinitroaniline-resistant species. Sequences were retrieved from UniProt with the identifiers listed below and subjected to a multiple sequence alignment using ClustalOmega (ebi.ac.uk/Tools/msa/clustalo/; ClustalOmega webserver, last accessed 16-02-23):
alpha-tubulin:
- [dinitroaniline sensitive] T. cruzi - Q27352; T. brucei brucei - Q4GYY5; L. infantum - ...
Submitter: Ina Poehner
Biological problem addressed: Model Analysis Type
Investigation: Antiparasitic dinitroaniline-ether phospholipid...
