BinGO analysis of downregulated miRNA - gene targets Version 1
Previously identified gene targets were used as input (see miRNA gene target file).
Literature-curated transcription factor (TF) - miRNA pairs of deregulated miRNAs were extracted from TransmiR (Tong, Cui and Wang 2019 TransmiR). miRNA, target gene, and TF Interaction pairs were visualized in Cytoscape v3.8.2 (Shannon, P. et al. Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Research 13, 2498-2504, doi:Doi 10.1101/Gr.1239303 (2003). The missing interactions within the resulting network were integrated using the Cytoscape App Bisogenet v3.0.0 (Martin et al 2010 BisoGenet).
Cytoscape BinGO plugin was used to identify overrepresented GO terms.
SEEK ID: https://fairdomhub.org/data_files/4179?version=1
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Supplementals D 1 BinGO_downtargets.bgo
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Created: 11th Jun 2021 at 09:33
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Version 1 (earliest) Created 11th Jun 2021 at 09:33 by Julia Scheel
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Projects: COVID-19 Disease Map, Molecular characterization and angiogenic properties of extracellular vesicles in healthy and preeclamptic amniotic fluid, Overexpression of microRNAs miR-25-3p, miR-185-5p and miR-132-3p in Late Onset Fetal Growth Restriction, Validation of Results and Study of the Biochemical Pathways Involved, Comparative Proteome Profile of Placental Sub-anatomical regions, The deregulated interplay of complement system and antioxidant activity as a driver of adverse pregnancy outcomes
Institutions: University of Rostock, Instituto de Investigación Sanitaria La Fe
https://orcid.org/0000-0002-0034-7755
The principal research aim of iPLACENTA is to improve our ability to study, model and visualise the placenta. This will contribute to developing diagnostic tests and therapies for pregnancy complications such as preeclampsia and intrauterine growth restriction (IUGR). Placental defects are thought to be the cause of many major pregnancy complications, such as preeclampsia and intra-uterine growth restriction. Preeclampsia affects between 5 and 8 out of every 100 pregnant women and claims the lives ...
Projects: Molecular characterization and angiogenic properties of extracellular vesicles in healthy and preeclamptic amniotic fluid, Overexpression of microRNAs miR-25-3p, miR-185-5p and miR-132-3p in Late Onset Fetal Growth Restriction, Validation of Results and Study of the Biochemical Pathways Involved, Comparative Proteome Profile of Placental Sub-anatomical regions, The deregulated interplay of complement system and antioxidant activity as a driver of adverse pregnancy outcomes
Web page: https://www.iplacenta.eu/
