Safety, Tolerability, Pharmacokinetics, and Antimalarial Activity of the Novel Plasmodium Phosphatidylinositol 4-Kinase Inhibitor MMV390048 in Healthy Volunteers

Abstract:
          MMV390048 is a novel antimalarial compound that inhibits
          Plasmodium
          phosphatidylinositol-4-kinase. The safety, tolerability, pharmacokinetic profile, and antimalarial activity of MMV390048 were determined in healthy volunteers in three separate studies. A first-in-human, double-blind, randomized, placebo-controlled, single-ascending-dose study was performed. Additionally, a volunteer infection study investigated the antimalarial activity of MMV390048 using the
          Plasmodium falciparum
          induced blood-stage malaria (IBSM) model.

SEEK ID: https://fairdomhub.org/publications/662

DOI: 10.1128/AAC.01896-19

Projects: WP 4: Evaluation of drug activity against multiple life cycle stages of ...

Publication type: Journal

Journal: Antimicrobial Agents and Chemotherapy

Citation: Antimicrob Agents Chemother 64(4),e01896-19

Date Published: 24th Mar 2020

Registered Mode: by DOI

Authors: Phumla Sinxadi, Cristina Donini, Hilary Johnstone, Grant Langdon, Lubbe Wiesner, Elizabeth Allen, Stephan Duparc, Stephan Chalon, James S. McCarthy, Ulrike Lorch, Kelly Chibale, Jörg Möhrle, Karen I. Barnes

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Sinxadi, P., Donini, C., Johnstone, H., Langdon, G., Wiesner, L., Allen, E., Duparc, S., Chalon, S., McCarthy, J. S., Lorch, U., Chibale, K., Möhrle, J., & Barnes, K. I. (2020). Safety, Tolerability, Pharmacokinetics, and Antimalarial Activity of the Novel Plasmodium. In Antimicrobial Agents and Chemotherapy (Vol. 64, Issue 4). American Society for Microbiology. https://doi.org/10.1128/aac.01896-19
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Created: 9th Jan 2023 at 10:45

Last updated: 9th Jan 2023 at 10:46

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