Safety, Tolerability, Pharmacokinetics, and Antimalarial Activity of the Novel Plasmodium Phosphatidylinositol 4-Kinase Inhibitor MMV390048 in Healthy Volunteers

          MMV390048 is a novel antimalarial compound that inhibits
          phosphatidylinositol-4-kinase. The safety, tolerability, pharmacokinetic profile, and antimalarial activity of MMV390048 were determined in healthy volunteers in three separate studies. A first-in-human, double-blind, randomized, placebo-controlled, single-ascending-dose study was performed. Additionally, a volunteer infection study investigated the antimalarial activity of MMV390048 using the
          Plasmodium falciparum
          induced blood-stage malaria (IBSM) model.


DOI: 10.1128/AAC.01896-19

Projects: WP 4: Evaluation of drug activity against multiple life cycle stages of ...

Publication type: Journal

Journal: Antimicrobial Agents and Chemotherapy

Citation: Antimicrob Agents Chemother 64(4),e01896-19

Date Published: 24th Mar 2020

Registered Mode: by DOI

Authors: Phumla Sinxadi, Cristina Donini, Hilary Johnstone, Grant Langdon, Lubbe Wiesner, Elizabeth Allen, Stephan Duparc, Stephan Chalon, James S. McCarthy, Ulrike Lorch, Kelly Chibale, Jörg Möhrle, Karen I. Barnes

help Submitter
Sinxadi, P., Donini, C., Johnstone, H., Langdon, G., Wiesner, L., Allen, E., Duparc, S., Chalon, S., McCarthy, J. S., Lorch, U., Chibale, K., Möhrle, J., & Barnes, K. I. (2020). Safety, Tolerability, Pharmacokinetics, and Antimalarial Activity of the Novel Plasmodium. In Antimicrobial Agents and Chemotherapy (Vol. 64, Issue 4). American Society for Microbiology.

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Created: 9th Jan 2023 at 09:45

Last updated: 9th Jan 2023 at 09:46

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