Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase

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Abstract:

          MMV390048, a member of a new class of inhibitors of the
          Plasmodium
          phosphatidylinositol 4-kinase, shows potential for both treatment and prophylaxis.

SEEK ID: https://fairdomhub.org/publications/660

DOI: 10.1126/scitranslmed.aad9735

Projects: WP 4: Evaluation of drug activity against multiple life cycle stages of ...

Publication type: Journal

Journal: Science Translational Medicine

Citation: Sci. Transl. Med. 9(387),eaad9735

Date Published: 26th Apr 2017

Registered Mode: by DOI

Authors: Tanya Paquet, Claire Le Manach, Diego González Cabrera, Yassir Younis, Philipp P. Henrich, Tara S. Abraham, Marcus C. S. Lee, Rajshekhar Basak, Sonja Ghidelli-Disse, María José Lafuente-Monasterio, Marcus Bantscheff, Andrea Ruecker, Andrew M. Blagborough, Sara E. Zakutansky, Anne-Marie Zeeman, Karen L. White, David M. Shackleford, Janne Mannila, Julia Morizzi, Christian Scheurer, Iñigo Angulo-Barturen, María Santos Martínez, Santiago Ferrer, Laura María Sanz, Francisco Javier Gamo, Janette Reader, Mariette Botha, Koen J. Dechering, Robert W. Sauerwein, Anchalee Tungtaeng, Pattaraporn Vanachayangkul, Chek Shik Lim, Jeremy Burrows, Michael J. Witty, Kennan C. Marsh, Christophe Bodenreider, Rosemary Rochford, Suresh M. Solapure, María Belén Jiménez-Díaz, Sergio Wittlin, Susan A. Charman, Cristina Donini, Brice Campo, Lyn-Marie Birkholtz, Kirsten K. Hanson, Gerard Drewes, Clemens H. M. Kocken, Michael J. Delves, Didier Leroy, David A. Fidock, David Waterson, Leslie J. Street, Kelly Chibale

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Dina Coertzen

Citation

Paquet, T., Le Manach, C., Cabrera, D. G., Younis, Y., Henrich, P. P., Abraham, T. S., Lee, M. C. S., Basak, R., Ghidelli-Disse, S., Lafuente-Monasterio, M. J., Bantscheff, M., Ruecker, A., Blagborough, A. M., Zakutansky, S. E., Zeeman, A.-M., White, K. L., Shackleford, D. M., Mannila, J., Morizzi, J., … Chibale, K. (2017). Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium. In Science Translational Medicine (Vol. 9, Issue 387). American Association for the Advancement of Science (AAAS). https://doi.org/10.1126/scitranslmed.aad9735

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Created: 9th Jan 2023 at 09:35

Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase

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