P. Stroe

The Transversal–Longitudinal Pathogenetic Theory (TLPT) is a systems‑biology framework that models disease emergence, progression, and resolution through the interaction of master‑switch nodes, transversal fluxes, longitudinal architectural layers, and meta‑attractor dynamics. TLPT integrates causal chains, pathogenic axes, transversal flows, feedback loops, pathological attractors, and the transversal meta‑attractor into a unified pathogenetic pyramid composed of seven hierarchical levels. The ...

Transversal–Longitudinal Pathogenetic Theory (TLPT) is a network-based systems biology theory describing universal pathogenetic architecture through transversal fluxes, longitudinal axes, causal chains, feedback loops, pathogenic attractors, and the transversal meta-attractor. TLPT defines the complete set of master-switch nodes (Nrf2, NF‑κB/NLRP3, SCFA–GPR, AhR, NO/eNOS, AMPK, GLP‑1, SIRT1, TGF‑β, PPAR, mTOR, HIF‑1α) and formal rules for their activation, coherence, persistence, and dominance. ...