Karsten Klein

Here we share resources and best practices to develop a disease map for COVID-19. The project is progressing as a broad community-driven effort. We aim to establish a knowledge repository on virus-host interaction mechanisms specific to the SARS-CoV-2. The COVID-19 Disease Map is an assembly of molecular interaction diagrams established based on literature evidence.

We performed topological analysis on pathways from a harmonised dataset containing pathways from the COVID-19 Disease Map, WikiPathways, and Reactome. The analysis was done using Vanted, SBGN-ED, and LMME which support the import and export of several standard formats (such as SBML, and SBGN-ML).

To allow detailed visual analysis of the overall system and its parts, we used a customised version of our Vanted add-on LMME (Large Metabolic Model Explorer) to construct an overview graph showing one node per pathway and the respective interconnecting species. We performed a comprehensive analysis of node centralities on two levels: on the level of the individual pathways as well as on the level of an aggregated network which is composed of the individual pathways. This allows detailed ...