Projects

The placenta remains the key to maternal diseases such as Pre-eclampsia (PE) and Intrauterine growth restriction (IUGR), however the pathophysiology of these disorders remains elusive. The aim of this study is to characterize the key proteomic variations between PE and IUGR, to better understand the pathoetiology of these diseases.Term placentas each were collected from PE, IUGR pregnancies, and age and BMI matched healthy controls. Quadrupole-orbitrap mass spectrometer was used in data dependent ...

Placental dysfunction has been associated with various pregnancy complications leading to both maternal and fetal death and long-term consequences, however, the placenta is one of the least studied organs within the human body. In this pilot study, protein signature of three healthy placentae was measured using label free quantification mass spectrometry. Each placenta was sampled in five sample sites and three sub-anatomical regions. Differentially expressed proteins were identified considering ...

Here we share resources and best practices to develop a disease map for COVID-19. The project is progressing as a broad community-driven effort. We aim to establish a knowledge repository on virus-host interaction mechanisms specific to the SARS-CoV-2. The COVID-19 Disease Map is an assembly of molecular interaction diagrams established based on literature evidence.

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