Louise Pease
SEEK ID: https://fairdomhub.org/people/1480
Location:
United Kingdom
ORCID:
https://orcid.org/0000-0002-3792-6275
Joined: 10th Jan 2020
Expertise: Not specified
Tools: Not specified
Their tagsRelated items
Systems modelling molecular mechanisms of ageing
Projects: Systems modelling age-related changes in the maintenance of dermal extra-cellular matrix: mechanisms and interventions, Are microRNAs key mediators of cartilage destruction in osteoarthritis?, Dynamic interplay between nuclei and mitochondria in ageing cells, Outreach - Senescence RStudio-Shiny application, Outreach - Simulation of cellular senescence using an agent based modelling approach
Web page: https://www.ncl.ac.uk/camb/staff/profile/darylshanley.html
This project aims to develop an agent based model using the Netlogo package which can then be used for outreach in schools and the wider community. This model represents cellular senescence in skin with the potential for users to explore the effects of combination treatments in silico.
Programme: Newcastle University Systems Modelling of Ageing
Public web page: Not specified
Web application developed using RStudio-Shiny for outreach. Incorporates information, videos and images, worksheets and simulations surrounding cellular senescence and therapy. Incorporates NetLogo simulation from "Outreach - Simulation of cellular senescence using an agent based modelling approach" project.
Programme: Newcastle University Systems Modelling of Ageing
Public web page: Not specified
Overall, we will measure in-vitro and model in-silico the short-term biochemical network dynamics of extra cellular matrix maintenance (ECM) in populations of young, old and senescent dermal fibroblasts. We have shown in previous work that differences in network dynamics are highly informative and provide a means to identify parts of the network that could be targeted to restore healthy function.
The work will be first carried out in 2D culture of human dermal fibroblasts then extended to a novel ...
