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HSD11B1 inhibition in human adipose tissue

Excel spreadsheet with 72h time points for metabolism of cortisone or 11KA4 in human subcutaneous or omental adipose tissue in presence or absence of AZD4017 inhibitor.

Creator: Jacky Snoep

Submitter: Jacky Snoep

Investigations: Effect of 11BHSD inhibition on 11-ketotestoster...

Studies: Inhibition of HSD11B1 in adipose tissue

Assays: Inhibition of HSD11B1 in adipose tissue

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Created: 24th Feb 2024 at 14:39

Data file for HSD11B1/AKR1C3 conversion with CBX inhibition

Steroid biosynthesis

HSD11B1 was inhibited by CBX and the effect on the conversion of cortisone and 11KA4 in HSD11B1/AKR1C3 incubations was followed.

Creator: Jacky Snoep

Submitter: Jacky Snoep

Investigations: Effect of 11BHSD inhibition on 11-ketotestoster...

Studies: CBX inhibition of HSD11B1 and effect on HSD11B1...

Assays: Experimental data for HSD11B1/AKR1C3 incubation...

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Created: 19th Feb 2024 at 13:42

Ratio experiments

Steroid biosynthesis

Metabolite profiles after 24h incubation with different ratios of HSD11B1 and AKR1C3 transfected HEK293 cells.

Creator: Jacky Snoep

Submitter: Jacky Snoep

Investigations: Effect of 11BHSD inhibition on 11-ketotestoster...

Studies: HSD11B1/AKR1C3 ratio experiments

Assays: Data for HSD11B1/AKR1C3 ratio experiment in Fig. 2

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Created: 16th Feb 2024 at 13:43

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