Cancer Hallmark Consensus

The hallmarks of cancer provide a highly cited and well-used conceptual framework for describing the processes involved in cancer cell development. However, methods for translating these high-level concepts into data-level associations between hallmarks and genes (for high throughput analysis), vary widely between studies. In this investigation we compare cancer hallmark mapping strategies from different studies, based on Gene Ontology and biological pathway annotation. By analysing the semantic similarity between annotations, and the resulting gene set overlap, we identify emerging consensus knowledge.

Investigation position:

help Creators and Submitter

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Created: 22nd Jan 2021 at 16:43

Last updated: 9th Feb 2021 at 10:03

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