Research Training Group 2901 SYLOBIO

Systemic and local reactions in case of incompatibility to biomaterials for joint and skin lesions

Incompatibility to biomaterials and the body's response

Biomaterials serve as temporary or permanent replacements for tissue structures that are irreversibly damaged or functionally impaired. Possible incompatibility of biomaterials used for total joint replacements and dressings for chronic wounds is triggered by inflammatory reactions in the host tissue, ...

The project addresses the generation and establishment of programmed pacemaker cells for an in vitro drug testing possibility to perform predictive tests. This may lead to an improved treatment of cardiac arrhythmias or an accurate identification of potential drug molecules at a very early stage of development. Important benefits will arise in verifying the safety of a wide variety of medicines while reducing animal testing. For more information you may visit our project website at ...

With aging comes cellular senescence, and (multi-)morbidity. Cellular senescence is a key driver of an interconnected disease network including cancer and stroke. We wish to utilize systems modeling and bioinformatics, learning from omics and other lab data, to design and develop a biomarker + software kit with a focus on measuring and interpreting senescence-related signatures for precise (and early) diagnosis, prognosis, and, ultimately, therapy, of pancreatic cancer and ischemic stroke/thromboembolism. ...