Transversal–Longitudinal Pathogenetic Theory (TLPT)

Version 1

Transversal–Longitudinal Pathogenetic Theory (TLPT) is a network-based systems biology theory describing universal pathogenetic architecture through transversal fluxes, longitudinal axes, causal chains, feedback loops, pathogenic attractors, and the transversal meta-attractor. TLPT defines the complete set of master-switch nodes (Nrf2, NF‑κB/NLRP3, SCFA–GPR, AhR, NO/eNOS, AMPK, GLP‑1, SIRT1, TGF‑β, PPAR, mTOR, HIF‑1α) and formal rules for their activation, coherence, persistence, and dominance. The theory provides criteria for transversal–longitudinal stability, attractor emergence, and intervention module eligibility, offering a structured conceptual framework for modeling multisystemic pathogenetic processes.

Cross-linked Academic Resources for TLPT

Zenodo (Primary Repository): https://zenodo.org/records/21325928

Figshare Dataset: https://doi.org/10.6084/m9.figshare.32975795

OSF Registries (TLPT Registration): https://osf.io/a9r7j/overview