Zip-archive with top-ranked (by IFDScore) induced fit docking results for each dinitroaniline etherphospholipid hybrid compounds 1, 2, 4, 8 and reference compound trifluraline, docked to the pironetin site of a Trypanosoma cruzi alpha-tubulin homology model built on PDB-ID 5ubq. The docking grid was centered on site residue Leu238 (T. cruzi numbering).
The docking results were obtained by Induced Fit docking with Schrödinger Glide and Prime in the Induced Fit docking workflow (Schrödinger, LLC, New York, NY, Schrödinger Release 2017-1, 2017, Induced Fit Docking Protocol, Glide v11.1 and Prime PSP v4.7).
Description: Zip-archive with top-ranked (by IFDScore) induced fit docking results for each dinitroaniline etherphospholipid hybrid...
SEEK ID: https://fairdomhub.org/data_files/6430
- Antiparasitic dinitroaniline-ether phospholipid hybrids
- Computational identification of potential dinitroaniline binding sites in kinetoplastid alpha-tubulin
- Docking studies of trifluraline and the dinitroaniline-etherphospholipid hybrids against kinetoplastid alpha-tubulin
- Preparation of multimeric tubulin docking receptors
- Induced-fit docking studies
- L. donovani alpha-tubulin M-loop top complexes from induced fit docking
- L. donovani alpha-tubulin N-loop top complexes from induced fit docking
- L. donovani alpha-tubulin MN-loop interface top complexes from induced fit docking
- L. infantum alpha-tubulin M-loop top complexes from induced fit docking
- L. infantum alpha-tubulin N-loop top complexes from induced fit docking
- L. infantum alpha-tubulin MN-loop interface top complexes from induced fit docking
- T. brucei alpha-tubulin M-loop top complexes from induced fit docking
- T. brucei alpha-tubulin N-loop top complexes from induced fit docking
- T. brucei alpha-tubulin MN-loop interface top complexes from induced fit docking
- T. cruzi alpha-tubulin M-loop top complexes from induced fit docking
- T. cruzi alpha-tubulin N-loop top complexes from induced fit docking
- T. cruzi alpha-tubulin MN-loop interface top complexes from induced fit docking
- T. cruzi alpha-tubulin Blume site top complexes from induced fit docking
- T. cruzi alpha-tubulin Consensus site top complexes from induced fit docking
- T. cruzi alpha-tubulin Consensus site top complexes from induced fit docking
- T. cruzi alpha-tubulin pironetin site top complexes from induced fit docking
- T. cruzi alpha-tubulin top complexes from induced fit docking based on trifluraline reference in Blume site
- T. cruzi alpha-tubulin top complexes from induced fit docking based on trifluraline reference in Consensus site
- T. cruzi alpha-tubulin top complexes from induced fit docking based on trifluraline reference in M-loop region
- T. cruzi alpha-tubulin top complexes from induced fit docking based on trifluraline reference in N-loop region
- T. cruzi alpha-tubulin top complexes from induced fit docking based on trifluraline reference in pironetin site
- SOP Induced fit docking
- Design, synthesis and biological evaluation of antiparasitic dinitroaniline-ether phospholipid hybrids
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Created: 20th Apr 2023 at 13:55
Last updated: 24th Apr 2023 at 13:36


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Version 1 (earliest) Created 20th Apr 2023 at 13:55 by Ina Poehner
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Related items
Projects: Kinetics on the move - Workshop 2016, COVID-19 Disease Map, NMTrypI - New Medicines for Trypanosomatidic Infections, CoVIDD - Coronavirus interactions in drug discovery - optimization and implementation
Institutions: Kinetics on the move Workshop at HITS, Heidelberg Institute for Theoretical Studies (HITS gGmbH), University of Eastern Finland (UEF)

Group Leader, Molecular and Cellular Modeling Group, EML Research, Heidelberg
Projects: NMTrypI - New Medicines for Trypanosomatidic Infections
Web page: https://cordis.europa.eu/programme/id/FP7_HEALTH.2013.2.3.4-2
The New Medicines for Trypanosomatidic Infections - NMTrypI project aimed at obtaining new candidate drugs against Trypanosomatidic infections with appropriate efficiency from the lead phase to the final preclinical phase that are more accessible to patients.
Programme: Drug development for neglected parasitic diseases
Public web page: https://fp7-nmtrypi.eu/
Start date: 1st Feb 2014
End date: 31st Jan 2017
Design, synthesis, computational studies and biological evaluation of antiparasitic dinitroaniline-ether phospholipid hybrids
Submitter: Ina Poehner
Studies: Computational identification of potential dinitroaniline binding sites i..., Docking studies of trifluraline and the dinitroaniline-etherphospholipid...
Assays: Comparative electrostatic analysis of dinitroaniline-sensitive and -resi..., Induced-fit docking studies, Multiple sequence alignment, Preparation of multimeric tubulin docking receptors
Snapshots: Snapshot 1
Induced fit docking studies of the dinitroaniline parent trifluraline and the newly designed dinitroaniline-etherphospholipid hybrids against different potential binding sites in monomeric and multimeric kinetoplastid tubulin receptors.
Submitter: Ina Poehner
Investigation: Antiparasitic dinitroaniline-ether phospholipid...
Assays: Induced-fit docking studies, Preparation of multimeric tubulin docking receptors
Snapshots: No snapshots
Docking results of trifluraline and dinitroaniline-etherphospholipid hybrids against different kinetoplastid alpha-tubulin receptors with an induced fit docking routine. The docking protocol involves an initial crude ligand placement step, subsequent receptor optimization in response to ligand binding, and another docking step into the optimized receptor.
Submitter: Ina Poehner
Biological problem addressed: Model Analysis Type
Investigation: Antiparasitic dinitroaniline-ether phospholipid...
Organisms: Trypanosoma cruzi, Trypanosoma brucei, Leishmania donovani, Leishmania infantum
Models: No Models
SOPs: SOP Induced fit docking
Data files: L. donovani alpha-tubulin M-loop top complexes ..., L. donovani alpha-tubulin MN-loop interface top..., L. donovani alpha-tubulin N-loop top complexes ..., L. infantum alpha-tubulin M-loop top complexes ..., L. infantum alpha-tubulin MN-loop interface top..., L. infantum alpha-tubulin N-loop top complexes ..., T. brucei alpha-tubulin M-loop top complexes fr..., T. brucei alpha-tubulin MN-loop interface top c..., T. brucei alpha-tubulin N-loop top complexes fr..., T. cruzi alpha-tubulin Blume site top complexes..., T. cruzi alpha-tubulin Consensus site top compl..., T. cruzi alpha-tubulin Consensus site top compl..., T. cruzi alpha-tubulin M-loop top complexes fro..., T. cruzi alpha-tubulin MN-loop interface top co..., T. cruzi alpha-tubulin N-loop top complexes fro..., T. cruzi alpha-tubulin pironetin site top compl..., T. cruzi alpha-tubulin top complexes from induc..., T. cruzi alpha-tubulin top complexes from induc..., T. cruzi alpha-tubulin top complexes from induc..., T. cruzi alpha-tubulin top complexes from induc..., T. cruzi alpha-tubulin top complexes from induc...
Snapshots: No snapshots