Design, synthesis and modelling of photoreactive chemical probes for investigating target engagement of plasmepsin IX and X in <i>Plasmodium falciparum</i>

Abstract:

We report the synthesis and biological profiling of photoreactive chemical probes based on an established plasmepsin X inhibitor scaffold. Maintained antimalarial and recombinant enzyme activity support their use in future chemical proteomic studies.

Citation: RSC Chem. Biol. 5(1):19-29.

Date Published: 2024

Registered Mode: by DOI

Authors: Monika Lisauskaitė, Gemma L. Nixon, Christopher M. Woodley, Neil G. Berry, Andy Coninckx, L. Charlie Qie, Suet C. Leung, Donatella Taramelli, Nicoletta Basilico, Silvia Parapini, Stephen A. Ward, Oscar Vadas, Dominique Soldati-Favre, W. David Hong, Paul M. O'Neill

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Lisauskaitė, M., Nixon, G. L., Woodley, C. M., Berry, N. G., Coninckx, A., Qie, L. C., Leung, S. C., Taramelli, D., Basilico, N., Parapini, S., Ward, S. A., Vadas, O., Soldati-Favre, D., Hong, W. D., & O'Neill, P. M. (2024). Design, synthesis and modelling of photoreactive chemical probes for investigating target engagement of plasmepsin IX and X in Plasmodium falciparum. In RSC Chemical Biology (Vol. 5, Issue 1, pp. 19–29). Royal Society of Chemistry (RSC). https://doi.org/10.1039/d3cb00109a
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Created: 14th Jul 2026 at 06:57

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