Armida Fabius
SEEK ID: https://fairdomhub.org/people/2199
Location:
Netherlands
ORCID:
https://orcid.org/0000-0002-1220-1868
Joined: 14th Jul 2022
Expertise: Not specified
Tools: Not specified
Roles
Project administrator
Asset housekeeper
Asset gatekeeper
Programme administrator
Their tagsRelated items
Background. RB1 is a paradigm gene for heritable cancer. Almost all RB1 mutation-carriers develop retinoblastoma (heritable-Rb-patient) during childhood and many heritable-Rb-survivors develop second primary malignancies (SPMs; notably sarcomas and melanomas) throughout life, which are often fatal. To date, no standard protocols are available for early detection of SPMs. Recently, blood-based cancer tests have opened up encouraging new possibilities for surveillance. We have developed novel ...
Projects: NIRBTEST
Web page: Not specified
Rationale: Individuals with a cancer predisposition due to a mutation in the paradigm tumor suppressor gene RB1, have a high risk to develop the childhood cancer retinoblastoma (Rb). Biopsies are not possible in Rb, before treatment selection. Heritable Rb patients have also a high risk to develop other types of second primary, either childhood or adult, malignancies (SPMs), notably sarcomas and melanomas. Remarkably, SPMs are now the leading cause of death in heritable-Rb-survivors. Unfortunately, ...
Public web page: Not specified
