Projects

The Transversal–Longitudinal Pathogenetic Theory (TLPT) is a systems‑biology framework that models disease emergence, progression, and resolution through the interaction of master‑switch nodes, transversal fluxes, longitudinal architectural layers, and meta‑attractor dynamics. TLPT integrates causal chains, pathogenic axes, transversal flows, feedback loops, pathological attractors, and the transversal meta‑attractor into a unified pathogenetic pyramid composed of seven hierarchical levels. The ...

Here we share resources and best practices to develop a disease map for COVID-19. The project is progressing as a broad community-driven effort. We aim to establish a knowledge repository on virus-host interaction mechanisms specific to the SARS-CoV-2. The COVID-19 Disease Map is an assembly of molecular interaction diagrams established based on literature evidence.