Data files

Complete posterior distributions for each drug and condition.

The files are in the hdf5 format and contain the complete information of the analysis for a FAIR data sharing.

The parameters A and B were estimated for the function f(x)=x⋅e^(B-Ax) and the AUC was calculated for the decay phase only. For OH-Midazolam the fourth replicate in the 2 weeks condition has an outlier in the measurement after six hours (more than 2SD above the mean of this condition) and was omitted for the AUC calculation as this could not be fitted to an exponential decay.

CYP2E1: Generic Classification 128

• MNT-021_Bl6J_J-20-0152_CYP2E1- 1/400_Run 011_LLL(green), RML(red), RSL (black), ICL(yellow)_MAA_006 >Control
• MNT-022_Bl6J_J-20-0154_CYP2E1- 1/400_Run 011_LLL(green), RML(red), RSL (black), ICL(yellow)_MAA_006 >Control
• MNT-023_Bl6J_J-20-0156_CYP2E1- 1/400_Run 011_LLL(green), RML(red), RSL (black), ICL(yellow)_MAA_006 >Control
• MNT-024_Bl6J_J-20-0158_CYP2E1- 1/400_Run 011_LLL(green), RML(red), RSL (black), ICL(yellow)_MAA_006 >Control
• MNT-025_Bl6J_J-20-0160_CYP2E1- 1/400_Run ...

• MNT-021_Bl6J_J-20-0152_CYP2E1- 1/400_Run 011_LLL(green), RML(red), RSL (black), ICL(yellow)_MAA_006 >Control
• MNT-022_Bl6J_J-20-0154_CYP2E1- 1/400_Run 011_LLL(green), RML(red), RSL (black), ICL(yellow)_MAA_006 >Control
• MNT-023_Bl6J_J-20-0156_CYP2E1- 1/400_Run 011_LLL(green), RML(red), RSL (black), ICL(yellow)_MAA_006 >Control
• MNT-024_Bl6J_J-20-0158_CYP2E1- 1/400_Run 011_LLL(green), RML(red), RSL (black), ICL(yellow)_MAA_006 >Control
• MNT-025_Bl6J_J-20-0160_CYP2E1- 1/400_Run ...

• MNT-021_Bl6J_J-20-0152_CYP2D6- 1/3000_Run 14_LLL(green), RML(red), RSL (black), ICL(yellow)_MAA_004 > Control
• MNT-022_Bl6J_J-20-0154_CYP2D6- 1/3000_Run 14_LLL(green), RML(red), RSL (black), ICL(yellow)_MAA_004 > Control
• MNT-023_Bl6J_J-20-0156_CYP2D6- 1/3000_Run 14_LLL(green), RML(red), RSL (black), ICL(yellow)_MAA_004 > Control
• MNT-024_Bl6J_J-20-0158_CYP2D6- 1/3000_Run 14_LLL(green), RML(red), RSL (black), ICL(yellow)_MAA_004 > Control
• MNT-025_Bl6J_J-20-0160_CYP2D6- 1/3000_Run ...

• MNT-021_Bl6J_J-20-0152_CYP2D6- 1/3000_Run 14_LLL(green), RML(red), RSL (black), ICL(yellow)_MAA_004 > Control
• MNT-022_Bl6J_J-20-0154_CYP2D6- 1/3000_Run 14_LLL(green), RML(red), RSL (black), ICL(yellow)_MAA_004 > Control
• MNT-023_Bl6J_J-20-0156_CYP2D6- 1/3000_Run 14_LLL(green), RML(red), RSL (black), ICL(yellow)_MAA_004 > Control
• MNT-024_Bl6J_J-20-0158_CYP2D6- 1/3000_Run 14_LLL(green), RML(red), RSL (black), ICL(yellow)_MAA_004 > Control
• MNT-025_Bl6J_J-20-0160_CYP2D6- 1/3000_Run ...

CYP1A2: Generic Classification 128

• MNT-021_J-20-0152_Bl6J_CYP1A2-1/500_Run 08_LLL(green), RML(red), RSL (black), ICL(yellow)_MAA_002 > Control
• MNT-022_J-20-0154_Bl6J_CYP1A2-1/500_Run 08_LLL(green), RML(red), RSL (black), ICL(yellow)_MAA_002 > Control
• MNT-023_J-20-0156_Bl6J_CYP1A2-1/500_Run 08_LLL(green), RML(red), RSL (black), ICL(yellow)_MAA_002 > Control
• MNT-024_J-20-0158_Bl6J_CYP1A2-1/500_Run 08_LLL(green), RML(red), RSL (black), ICL(yellow)_MAA_002 > Control
• MNT-025_J-20-0160_Bl6J_CYP1A2-1/500_Run ...

• MNT-021_J-20-0152_Bl6J_CYP1A2-1/500_Run 08_LLL(green), RML(red), RSL (black), ICL(yellow)_MAA_002 > Control
• MNT-022_J-20-0154_Bl6J_CYP1A2-1/500_Run 08_LLL(green), RML(red), RSL (black), ICL(yellow)_MAA_002 > Control
• MNT-023_J-20-0156_Bl6J_CYP1A2-1/500_Run 08_LLL(green), RML(red), RSL (black), ICL(yellow)_MAA_002 > Control
• MNT-024_J-20-0158_Bl6J_CYP1A2-1/500_Run 08_LLL(green), RML(red), RSL (black), ICL(yellow)_MAA_002 > Control
• MNT-025_J-20-0160_Bl6J_CYP1A2-1/500_Run ...

CYP3A4: Generic Classification 128

• MNT-021_J-20-0152_CYP3A4 1/2000_Run 10_LLL(green), RML(red), RSL (black), ICL(yellow)_MAA_005 > Control
• MNT-022_J-20-0154_CYP3A4 1/2000_Run 10_LLL(green), RML(red), RSL (black), ICL(yellow)_MAA_005 > Control
• MNT-023_J-20-0156_CYP3A4 1/2000_Run 10_LLL(green), RML(red), RSL (black), ICL(yellow)_MAA_005 > Control
• MNT-024_J-20-0158_CYP3A4 1/2000_Run 10_LLL(green), RML(red), RSL (black), ICL(yellow)_MAA_005 > Control
• MNT-025_J-20-0160_CYP3A4 1/2000_Run 10_LLL(green), RML(red), ...

• MNT-021_J-20-0152_HE_LLL(green), RML(red), RSL (black), ICL(yellow)_MAA_003 > Control
• MNT-022_J-20-0154_HE_LLL(green), RML(red), RSL (black), ICL(yellow)_MAA_003 > Control
• MNT-023_J-20-0156_HE_LLL(green), RML(red), RSL (black), ICL(yellow)_MAA_003 > Control
• MNT-024_J-20-0158_HE_LLL(green), RML(red), RSL (black), ICL(yellow)_MAA_003 > Control
• MNT-025_J-20-0160_HE_LLL(green), RML(red), RSL (black), ICL(yellow)_MAA_003 > Control
• MNT-026_J-20-0162_HE_LLL(green), RML(red), ...

For each drug and condition, there is one:

• Visualization of the marginals and the sampling traces
• The credibility intervals for the parameters with the median
• Visualization of the individual ensemble output predictions with boxplots of the underlying data

Furthermore all conditions of the ensemble output predictions for one drug are visulized in one plot.

One example of a ReStoRunT sheet.

This file is part of a tutorial for the Gesellschaft für Ökologie and the NFDI4Biodiversity.

The file describe the methodology of the used algorithm to calculate the sensitivities against knockout and over-expression perturbations. The sensitivity values were classified in macro values for every perturbation. The bitwise distances were calculated for each biomolecule in the same macro class

Summary of identified ribosomal proteins of P. cordatum.

Summary table of identified pigment binding proteins with relative shares in % and calculations of total amount of pigment binding proteins in the different data sets.

Complete list of differentially expressed proteins between sub-anatomical regions. Non significant results were filtered out.

Complete list of differentially expressed proteins between sub-anatomical regions. Non significant results were filtered out.

Batch sample publishing

Batch sample publishing