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Molecular origins of mutational spectra produced by the environmental carcinogen N-nitrosodimethylamine and SN1 chemotherapeutic agents

MIT SRP

Amanda L. Armijo, Pennapa Thongaram, Bogdan I. Fedeles, Judy Yau, Jennifer E Kay, Joshua J. Corrigan, Marisa Chancharoen, Supawadee Chawanthayatham, Leona D. Samson, Sebastian E. Carrasco, Bevin P. Engelward, James G. Fox, Robert G. Croy & John M. Essigmann

DNA-methylating environmental carcinogens such as N-nitrosodimethylamine (NDMA) and certain alkylators used in chemotherapy form O6-methylguanine (m6G) as a functionally critical intermediate. NDMA ...

Submitter: Charles Demurjian

Investigation: MIT SRP

Assays: Extraction and Library Creation - Metadata, GPT Assay - Data Attached, Genome Alignment - Data Linked, Illumina Sequencing - Data Linked, Mutational Spectral Analysis - Data Attached, Necropsy - Metadata

Snapshots: Snapshot 1

Created: 9th Feb 2023 at 21:50, Last updated: 8th Mar 2023 at 22:25

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