VACO PTPN11 KO perturbations
Version 1

Log2 fold changes after drug treatment/serum stimulation of MAPK and AKT pathway nodes

SEEK ID: https://fairdomhub.org/data_files/3065?version=1

Filename: vaco_ko_median_lfc.tsv  Download

Format: Tab-separated values document

Size: 6.64 KB

DOI: 10.15490/fairdomhub.1.datafile.3065.1

	egf	hgf	nrg1	plx	plx + egf	plx + hgf	plx + nrg1	mek	mek + egf	mek + hgf	mek + nrg1	erk	erk + egf	erk + hgf	erk + nrg1	akt	akt + egf	akt + hgf	akt + nrg1	pi3k	pi3k + egf	pi3k + hgf	pi3k + nrg1
EGFR	0.39733549754538494	0.5731853329448026	0.6424479953819163	0.5004289905094883	0.5731853329448026	0.39733549754538494	0.6197279188818328	0.28630418515664097	0.5004289905094883	0.6868421147403698	0.28630418515664097	0.16600995143892933	0.4498029174395205	0.5731853329448026	0.8519013610108661	0.39733549754538494	0.423807708906576	0.2274104961030724	0.7085371858396886	0.5004289905094883	0.6868421147403698	0.4498029174395205	0.39733549754538494
MEK	0.4209617398311108	0.6382157135103439	0.774128408872364	-5.997107087378588	-5.924957301622753	-5.790656209911162	-5.69754680551968	1.2667940622727378	1.1853509344670414	1.1848415082467452	1.4083617030514772	-0.2285834247097318	0.4373072967772899	0.7686996346739283	0.9666041464728917	0.6344897428419706	0.7818966556502057	0.5966910117065561	1.0049145054426867	0.5511714424139054	0.5586618830077064	0.20583297129168704	0.5384673863804045
ERK	0.5235619560570128	0.5849625007211562	0.8328900141647416	-0.5405683813627028	-0.4764380439429871	-0.2995602818589078	-0.04580368961312479	-0.3561438102252753	-0.19264507794239588	-0.14201900487242788	0.0	-0.4150374992788438	-0.3561438102252753	-0.24511249783653147	0.16992500144231237	0.4918530963296747	0.28540221886224837	0.42626475470209796	0.7279204545631992	0.32192809488736235	0.6438561897747247	0.45943161863729726	0.42626475470209796
P90RSK	0.3286227474613706	0.802553935793783	0.9660526680766622	-0.2168113890731482	-0.2563397532597855	0.21759143507262685	0.48062584090642063	-0.42626475470209796	0.15869774601905823	0.5044725828607884	0.15869774601905823	-0.3388019134517586	-0.2563397532597855	-0.03394733192333771	0.7234823648025842	-0.2969817377571315	-0.0687127500840142	-0.10433665981473561	0.15869774601905823	0.15869774601905823	0.0972972013549148	-0.1783372412585124	-0.1783372412585124
GSK3AB	1.2812861103900164	2.0033357125632563	2.1246957474493144	0.294961047287093	0.7086368711077118	1.6092471528445833	2.1978537450230196	0.7127180479195289	1.361456459074	1.756865151603911	2.3562481680712386	-0.11826288161981974	1.0524674198941355	1.604862058158861	1.9899463353360771	0.5397332467281585	0.3325753390868709	0.7086368711077118	1.0099840885726221	0.6288167903105837	0.6629650127224292	0.5305147166987798	0.7329525316595827
RPS6	0.8450253400236591	1.4150374992788437	1.645991934118716	-0.7548875021634687	-0.23132554610645567	0.07800251200127316	0.3325753390868709	-0.46948528330122025	0.026472211361191177	0.784271308944563	0.9175378398080271	-0.3973354975453848	0.0	-0.05444778402237646	1.0524674198941355	-0.05444778402237646	-0.11103131238874384	-0.02696704760026932	0.5670405927238937	-0.16992500144231246	-0.05444778402237646	-0.16992500144231246	-0.02696704760026932
PI3K	0.22239242133644802	0.41503749927884376	0.6880559936852598	-0.16992500144231246	0.0	0.15200309344505006	0.3536369546147004	0.0	0.289506617194985	0.07800251200127316	0.41503749927884376	0.0	0.22239242133644802	0.15200309344505006	0.6374299206152918	-0.16992500144231246	0.07800251200127316	-0.08246216019197299	0.41503749927884376	0.07800251200127316	0.41503749927884376	-0.08246216019197299	0.0
AKT	2.876193798385602	5.148677267738273	7.146803115987985	0.36678233067162275	2.351985328743542	5.32382513005996	7.072873035438051	1.3219280948873624	4.516944077292505	5.726487076361941	7.142510176116952	0.03747470541866296	1.9418970454364317	4.712074418624495	6.940043078540613	-0.24792751344358557	-0.1604646721932461	-0.2937312030567103	0.21150410519371182	-0.34103691783506696	0.0	0.0	-0.3899465183160133
MTOR	1.0297473433940518	1.5443205162238103	1.34577483684173	0.45943161863729726	0.5025003405291834	1.369233809665719	1.4150374992788437	0.5849625007211562	0.7369655941662062	1.2976805486406853	1.6911619045530812	-0.12553088208385899	0.5647846187835259	1.1429579538420431	1.1699250014423124	0.5443205162238102	0.5443205162238102	0.5443205162238102	0.7369655941662062	0.48112668973661615	0.7725895038969275	0.41503749927884376	0.5235619560570128
JNK	1.1375035237499351	1.3219280948873624	1.632268215499513	0.48542682717024166	0.632268215499513	0.925999418556223	1.070389327891398	0.5849625007211562	0.765534746362977	1.1043366598147355	0.5360529002402097	0.32192809488736235	0.5360529002402097	0.8073549220576041	1.4854268271702418	0.6780719051126377	0.6780719051126377	0.5360529002402097	0.8875252707415875	0.6780719051126377	0.8073549220576041	0.6780719051126377	0.43295940727610627
CJUN	0.33560303178443884	0.5849625007211562	1.0170735133589415	-0.22239242133644802	-0.2630344058337938	-0.03476541816067664	0.06711419585853703	-0.22239242133644802	-0.07038932789139803	0.06711419585853703	0.19264507794239583	-0.1443899093351748	-0.22239242133644802	0.13124453327825272	0.36257007938470837	-0.07038932789139803	-0.03476541816067664	-0.03476541816067664	0.13124453327825272	-0.1069152039165119	0.0	-0.18286405714981055	-0.1069152039165119
P38	0.0752881273042372	0.301169534720565	0.301169534720565	-0.13492958008610853	-0.1069152039165119	0.0	-0.1069152039165119	-0.16349873228287934	0.0	-0.05246741989413554	0.14684138832927118	-0.13492958008610853	0.05062607306996814	0.12338241550528205	0.32192809488736235	0.025535092107137478	-0.1069152039165119	-0.05246741989413554	0.16992500144231237	0.0752881273042372	0.12338241550528205	0.09953567355091437	-0.025995208532944573
IKBA	0.3410369178350669	0.717600269299275	1.078002512001273	0.12285674778553338	0.18057224564182084	0.20858662181141732	0.41503749927884376	-0.0324214776923775	0.2360673582335245	0.3155018257279294	0.15200309344505006	0.2360673582335245	0.20858662181141732	0.3661278987978975	0.7369655941662062	0.09310940439148145	0.06273575534796275	-0.24392558288608923	0.15200309344505006	0.20858662181141732	0.2630344058337938	0.03170885972733805	0.15200309344505006
P53	0.41503749927884376	0.9296106721086019	1.0	0.19264507794239583	0.30812229536233193	0.4656635723488118	0.5145731728297582	0.06711419585853703	0.2515387669959644	0.4656635723488118	0.06711419585853703	0.2515387669959644	0.4656635723488118	0.6520766965796931	0.777607578663552	0.06711419585853703	0.19264507794239583	0.0	0.30812229536233193	0.19264507794239583	0.36257007938470837	0.2515387669959644	0.2515387669959644
SMAD2	0.3590810933048283	0.5639008851933265	0.9358696625802845	-0.06413033741971558	-0.03170885972733814	0.14886338591448275	0.30932805810772873	-0.03170885972733814	0.2313255461064558	0.2313255461064558	0.3344190390705593	-0.16600995143892924	0.14886338591448275	0.20435849850618631	0.4988058569714417	0.12029423371771175	0.06140054466414327	-0.20163386116965057	0.28379296600059134	-0.06413033741971558	0.17687776208407918	-0.03170885972733814	0.12029423371771175
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Bosdriesz, E. (2020). VACO PTPN11 KO perturbations. FAIRDOMHub. https://doi.org/10.15490/FAIRDOMHUB.1.DATAFILE.3065.1
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Created: 9th Sep 2019 at 12:02

Last updated: 14th Jan 2020 at 15:03

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Version 1 (earliest) Created 9th Sep 2019 at 12:02 by Evert Bosdriesz

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