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Using optical tweezers to position yeast cells in a microfluidic chamber, we were able to observe sustained oscillations in individual isolated cells. Using a detailed kinetic model for the cellular reactions, we simulated the heterogeneity in the response of the individual cells, assuming small differences in a single internal parameter. By operating at two different flow rates per experiment, we observe four of categories of cell behaviour. The present model (gustavsson4) predicts the steady-state ...
Creators: Franco du Preez, Jacky Snoep, Dawie van Niekerk
Submitter: Franco du Preez
Model type: Ordinary differential equations (ODE)
Model format: Not specified
Environment: JWS Online
Using optical tweezers to position yeast cells in a microfluidic chamber, we were able to observe sustained oscillations in individual isolated cells. Using a detailed kinetic model for the cellular reactions, we simulated the heterogeneity in the response of the individual cells, assuming small differences in a single internal parameter. By operating at two different flow rates per experiment, we observe four of categories of cell behaviour. The present model (gustavsson1) predicts the limit ...
Creators: Franco du Preez, Jacky Snoep, David D van Niekerk
Submitter: Franco du Preez
Model type: Ordinary differential equations (ODE)
Model format: Not specified
Environment: JWS Online
Using optical tweezers to position yeast cells in a microfluidic chamber, we were able to observe sustained oscillations in individual isolated cells. Using a detailed kinetic model for the cellular reactions, we simulated the heterogeneity in the response of the individual cells, assuming small differences in a single internal parameter. By operating at two different flow rates per experiment, we observe four of categories of cell behaviour. The present model (gustavsson2) predicts the damped ...
Creators: Franco du Preez, Jacky Snoep, David D van Niekerk
Submitter: Franco du Preez
Model type: Ordinary differential equations (ODE)
Model format: Not specified
Environment: JWS Online
Using optical tweezers to position yeast cells in a microfluidic chamber, we were able to observe sustained oscillations in individual isolated cells. Using a detailed kinetic model for the cellular reactions, we simulated the heterogeneity in the response of the individual cells, assuming small differences in a single internal parameter. By operating at two different flow rates per experiment, we observe four of categories of cell behaviour. The present model (gustavsson3) predicts the steady-state ...
Creators: Franco du Preez, Jacky Snoep, David D van Niekerk
Submitter: Franco du Preez
Model type: Ordinary differential equations (ODE)
Model format: Not specified
Environment: JWS Online