Exercise-Induced Fitness Changes Correlate with Changes in Neural Specificity in Older Adults

Abstract:

Neural specificity refers to the degree to which neural representations of different stimuli can be distinguished. Evidence suggests that neural specificity, operationally defined as stimulus-related differences in functional magnetic resonance imaging (fMRI) activation patterns, declines with advancing adult age, and that individual differences in neural specificity are associated with individual differences in fluid intelligence. A growing body of literature also suggests that regular physical activity may help preserve cognitive abilities in old age. Based on this literature, we hypothesized that exercise-induced improvements in fitness would be associated with greater neural specificity among older adults. A total of 52 adults aged 59–74 years were randomly assigned to one of two aerobic-fitness training regimens, which differed in intensity. Participants in both groups trained three times a week on stationary bicycles. In the low-intensity (LI) group, the resistance was kept constant at a low level (10 Watts). In the high-intensity (HI) group, the resistance depended on participants’ heart rate and therefore typically increased with increasing fitness. Before and after the 6-month training phase, participants took part in a functional MRI experiment in which they viewed pictures of faces and buildings. We used multivariate pattern analysis (MVPA) to estimate the distinctiveness of neural activation patterns in ventral visual cortex (VVC) evoked by face or building stimuli. Fitness was also assessed before and after training. In line with our hypothesis, training-induced changes in fitness were positively associated with changes in neural specificity. We conclude that physical activity may protect against age-related declines in neural specificity.

SEEK ID: https://fairdomhub.org/publications/645

DOI: 10.3389/fnhum.2017.00123

Projects: Testing tools for research data management

Publication type: Journal

Journal: Frontiers in Human Neuroscience

Citation: Front. Hum. Neurosci. 11

Date Published: 16th Mar 2017

Registered Mode: by DOI

Authors: Maike M. Kleemeyer, Thad A. Polk, Sabine Schaefer, Nils C. Bodammer, Lars Brechtel, Ulman Lindenberger

help Submitter
Citation
Kleemeyer, M. M., Polk, T. A., Schaefer, S., Bodammer, N. C., Brechtel, L., & Lindenberger, U. (2017). Exercise-Induced Fitness Changes Correlate with Changes in Neural Specificity in Older Adults. In Frontiers in Human Neuroscience (Vol. 11). Frontiers Media SA. https://doi.org/10.3389/fnhum.2017.00123
Activity

Views: 90

Created: 25th May 2022 at 09:04

Last updated: 25th May 2022 at 09:06

help Tags

This item has not yet been tagged.

help Attributions

None

Powered by
(v.1.12.1)
Copyright © 2008 - 2022 The University of Manchester and HITS gGmbH

By continuing to use this site you agree to the use of cookies