Assays

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5 Assays visible to you, out of a total of 7

FIGURE 4: ATP indirectly stabilizes PRPP via pHis247.

NAMPT affinity

No description specified

Submitter: Dorothee Houry

Assay type: Experimental Assay Type

Technology type: Technology Type

Investigation: 1 hidden item

Study: Manuscript: structural determinants of substrat...

Organisms: No organisms

SOPs: No SOPs

Data files: No Data files

Snapshots: No snapshots

Created: 13th Nov 2019 at 15:47, Last updated: 13th Nov 2019 at 16:08

FIGURE 2: Crystal structures of human NAMPT in complex with NA and PRPP, or NAMN

NAMPT affinity

No description specified

Submitter: Dorothee Houry

Assay type: Experimental Assay Type

Technology type: Technology Type

Investigation: 1 hidden item

Study: Manuscript: structural determinants of substrat...

Organisms: No organisms

SOPs: No SOPs

Data files: No Data files

Snapshots: No snapshots

Created: 22nd Oct 2019 at 15:35, Last updated: 13th Nov 2019 at 16:08

FIGURE 3: ATP is essential for NAMN formation by NAMPT

NAMPT affinity

No description specified

Submitter: Dorothee Houry

Assay type: Experimental Assay Type

Technology type: Technology Type

Investigation: 1 hidden item

Study: Manuscript: structural determinants of substrat...

Organisms: No organisms

SOPs: No SOPs

Data files: Fig3: NAMN formation w/ and w/o ATP in WT NAMPT

Snapshots: No snapshots

Created: 22nd Oct 2019 at 15:44, Last updated: 13th Nov 2019 at 16:08

FIGURE 5: The deletion of the β1-β2 loop does not alter the geometry of the active site and yet, abolishes the effect of ATP on NAMPT activity

NAMPT affinity

No description specified

Submitter: Dorothee Houry

Assay type: Experimental Assay Type

Technology type: Technology Type

Investigation: 1 hidden item

Study: Manuscript: structural determinants of substrat...

Organisms: No organisms

SOPs: No SOPs

Data files: NMN and NAMN formation w/ and w/o ATP in Δ42-51...

Snapshots: No snapshots

Created: 22nd Oct 2019 at 15:57, Last updated: 13th Nov 2019 at 16:08

FIGURE 6: SAXS analysis of WT and Δ42-51 NAMPT.

NAMPT affinity

No description specified

Submitter: Dorothee Houry

Assay type: Experimental Assay Type

Technology type: Technology Type

Investigation: 1 hidden item

Study: Manuscript: structural determinants of substrat...

Organisms: No organisms

SOPs: No SOPs

Data files: SAXS raw data of WT and Δ42-51 NAMPT w/ Nam, NA...

Snapshots: No snapshots

Created: 22nd Oct 2019 at 16:03, Last updated: 13th Nov 2019 at 16:08

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