Programmes

Inactivation of the VHL tumor suppressor gene is linked to the development of several different tumor types in humans, including hemangioblastomas of the retina and central nervous system, clear cell renal carcinoma, pancreatic cysts, pheochromocytoma. Biochemical studies revealed that pVHL interacts with several different proteins serving as a multipurpose adaptor protein that engages in multiple protein-protein interactions to control diverse transcriptional-dependent and transcriptional-independent ...

IDPfun is an international consortium aiming to extend our knowledge on the functions of intrinsically disordered proteins (IDPs). Starting from available state of the art computational tools and databases, which have been mostly developed by IDPfun participants, it aims to drive a new level of IDP characterization.