ExploreLog2 fold changes after drug treatment/serum stimulation of MAPK and AKT pathway nodes
SEEK ID: https://fairdomhub.org/data_files/3064?version=1
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vaco_pe_median_lfc.tsv
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egf hgf nrg1 plx plx + egf plx + hgf plx + nrg1 mek mek + egf mek + hgf mek + nrg1 erk erk + egf erk + hgf erk + nrg1 akt akt + egf akt + hgf akt + nrg1 pi3k pi3k + egf pi3k + hgf pi3k + nrg1 EGFR 0.14585086646345485 0.3523017439308812 0.511500338780135 0.30339214344993476 0.2527660703799667 0.3761484858852489 0.3523017439308812 0.42269107182227916 0.14585086646345485 0.4898052676808161 -0.26918663281538907 0.22677086184702225 0.0892673380970873 0.0892673380970873 0.0892673380970873 0.0892673380970873 0.17333160288556176 0.0892673380970873 0.30339214344993476 0.11783649029385808 0.2527660703799667 0.06012099243757093 0.30339214344993476 MEK -0.039170597280677774 0.32192809488736235 0.7625006862733437 0.4500329206350477 0.6520766965796931 0.7999753916920066 0.4118135984045574 6.108897776754605 5.79603960882977 5.531381460516312 5.688250309133178 1.9772799234999165 2.05373198393779 2.0 2.301169534720565 0.40209844357134567 1.056831222596676 2.132224292257089 2.295932886354418 0.3321964303411894 0.8508565606941907 0.7318038890504274 0.9870609442925019 ERK 0.19930880822340666 0.289506617194985 0.41503749927884376 0.289506617194985 0.24511249783653138 0.5670405927238937 0.7686744538935444 0.10309349296410372 -0.16992500144231246 -0.05444778402237646 -0.11103131238874384 -0.29545588352617136 -0.11103131238874384 0.05246741989413548 -0.11103131238874384 0.45456586346548133 0.6026645024546152 0.7045441164738286 0.9175378398080271 0.3325753390868709 0.45456586346548133 0.493040011280117 0.3743955147814979 P90RSK 0.13124453327825272 0.06711419585853703 0.797507136101257 -0.03476541816067664 -0.03476541816067664 0.41503749927884376 1.1312445332782528 0.13124453327825272 0.2515387669959644 -0.1069152039165119 0.6076825772212396 0.03394733192333753 -0.07038932789139803 0.03394733192333753 0.03394733192333753 0.22239242133644802 0.22239242133644802 0.4656635723488118 0.797507136101257 0.22239242133644802 0.13124453327825272 0.03394733192333753 0.1622714288988771 GSK3AB 0.31174261104102874 0.8869373355133641 1.5752636740023547 0.07762089712247366 0.09129583401955027 1.0287112966415275 1.5232467162347405 0.38574319248480576 0.5531999383363683 0.6762583347407065 1.5333003808986636 -0.08973016065601223 0.4771175455055394 0.9890842225208165 1.7384148108032758 0.48231645217985863 0.5432844694712857 1.0533733508757965 1.003620315678697 0.6487775983185994 0.8869373355133641 0.8632212665395566 0.9520900150386149 RPS6 0.250543461650597 0.33184356375244506 1.3899465183160133 0.07275634243531415 0.33184356375244506 0.5514099410101295 1.649813645071124 0.0489096004809465 -0.025090980962830495 0.02466205423426903 1.096215315259303 -0.05062607306996795 -0.10309349296410361 -0.10309349296410361 0.02466205423426903 0.40880554556732934 0.20810819533020028 0.6338721012021026 1.0489096004809466 0.250543461650597 0.250543461650597 0.4274212237346762 0.4639470997597903 PI3K -0.07800251200127321 0.21150410519371182 0.4525122046975067 0.07400058144377678 -0.1604646721932461 0.27563444261342734 0.5594274086140185 0.21150410519371182 -0.1604646721932461 -0.07800251200127321 0.14438990933517493 0.07400058144377678 -0.07800251200127321 0.0 0.21150410519371182 0.07400058144377678 0.14438990933517493 0.07400058144377678 0.21150410519371182 0.3370349872775706 0.3959286763311393 0.07400058144377678 0.21150410519371182 AKT 0.2801079191927352 1.0995356735509143 5.146841388329271 0.4405725913859814 0.5501970825604795 1.6520766965796931 5.727920454563199 0.4780472968046442 0.7472339296200333 1.3219280948873624 5.301169534720565 0.23703919730084938 0.5849625007211562 0.8930847960834881 5.1799090900149345 0.36257007938470837 0.2801079191927352 0.2801079191927352 0.5501970825604795 0.23703919730084938 0.05062607306996814 0.4405725913859814 0.40209844357134567 MTOR 0.30485458152842093 0.8432744963125469 0.8898170822495771 0.19793937761190883 0.5272470028648688 0.9125371587496606 1.5418937788292701 0.2700891633677442 0.0418201756946269 0.2700891633677442 0.5272470028648688 -0.22948184612276734 0.2700891633677442 0.6938968722743202 0.9569312781081141 0.7705181538772327 0.46712601042729796 0.819427754358179 0.9569312781081141 0.5272470028648688 0.8667334691365358 1.0622842782543427 0.7705181538772327 JNK 0.13750352374993502 0.41503749927884376 0.5525410230287786 0.09310940439148145 0.04730571477835682 0.5525410230287786 0.6476982560691188 0.22239242133644802 0.3410369178350669 -0.2630344058337938 0.6780719051126377 0.13750352374993502 0.0 0.13750352374993502 0.09310940439148145 0.3025627700204313 0.37851162325372983 0.3410369178350669 0.7369655941662062 0.18057224564182084 0.48542682717024166 0.09310940439148145 0.41503749927884376 CJUN 0.18286405714981044 0.5454341365345188 0.5454341365345188 0.31410859042806305 0.28239973070072494 0.4629719763425457 0.7212839719339366 0.31410859042806305 0.24997825300834756 0.14809863898913392 0.5184670889342494 0.24997825300834756 -0.03952836418663734 0.28239973070072494 0.24997825300834756 0.3451354860486875 0.28239973070072494 0.28239973070072494 0.7678265578709667 0.40525647848625845 0.28239973070072494 0.37550913509220646 0.31410859042806305 P38 0.15919859484925394 0.11547721741993588 0.32192809488736235 0.04730571477835682 -0.0489096004809464 0.2630344058337938 0.22239242133644802 0.2016338611696504 0.04730571477835682 0.04730571477835682 -0.07400058144377693 0.09310940439148145 -0.0995356735509144 0.2630344058337938 0.0 -0.0995356735509144 0.070389327891398 0.0 0.15919859484925394 0.22239242133644802 0.0 0.13750352374993502 -0.0995356735509144 IKBA 0.15200309344505006 0.4388842412332116 0.717600269299275 0.20858662181141732 0.41503749927884376 0.6166713604484945 0.8300749985576875 0.3410369178350669 0.18057224564182084 0.2630344058337938 0.09310940439148145 0.3155018257279294 -0.16992500144231246 0.2630344058337938 0.2360673582335245 0.2360673582335245 -0.0995356735509144 0.09310940439148145 0.5742360941280977 -0.0324214776923775 0.06273575534796275 0.2630344058337938 0.06273575534796275 P53 0.13124453327825272 0.5145731728297582 0.6076825772212396 0.2515387669959644 0.19264507794239583 0.41503749927884376 0.561878887608115 0.4656635723488118 0.13124453327825272 0.19264507794239583 -0.07038932789139803 0.2515387669959644 0.13124453327825272 0.41503749927884376 0.36257007938470837 0.06711419585853703 0.06711419585853703 0.19264507794239583 0.19264507794239583 0.41503749927884376 0.30812229536233193 0.30812229536233193 0.13124453327825272 SMAD2 0.30485458152842093 0.43609911480667357 0.5563933485243854 0.16046467219324612 0.30485458152842093 0.40439025507933524 0.667424660913129 0.30485458152842093 0.16046467219324612 -0.18057224564182092 0.16046467219324612 0.23446525363702297 0.0418201756946269 0.19793937761190883 0.2700891633677442 0.23446525363702297 0.30485458152842093 0.2700891633677442 0.6129768768907526 0.0 0.16046467219324612 0.30485458152842093 0.3388019134517585
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Citation
Bosdriesz, E. (2020). VACO PTPN11 KO/BRAFi resistant perturbations. FAIRDOMHub. https://doi.org/10.15490/FAIRDOMHUB.1.DATAFILE.3064.1
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Created: 9th Sep 2019 at 12:01
Last updated: 14th Jan 2020 at 15:03
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Version 1 (earliest) Created 9th Sep 2019 at 12:01 by Evert Bosdriesz
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https://orcid.org/0000-0002-8788-9548
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The DrugLogics initiative comprises a number of different subprojects, all geared towards the development of personalised medicine, or precision medicine
Projects: CausalDB, Colosys, Crossover Research 2.0, NTNU Health Druglogics
Web page: http://druglogics.eu/
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The COLOSYS project aims to develop a deeper understanding of colon cancer networks and convert them into computer models with which it will be better to predict response to treatment. The combination of computational, experimental and clinical testing will provide understanding of drug resistance mechanisms, and allow personalised treatment of colon cancer.
Programme: Druglogics
Public web page: http://www.colosys.org/
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Submitter: Evert Bosdriesz
Biological problem addressed: Model Analysis Type
Investigation: 1 hidden item
Study: 1 hidden item
