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H The arrows mark the times when a mutant with a strong activation of the sensing of y arises (for the biphasic circuit depicted in F). This mutant has a selective disadvantage and is thus eliminated.
SED-ML simulation https://jjj.bio.vu.nl/models/experiments/karin2017_fig1h/simulate
Submitter: Jacky Snoep
Investigation: Karin et al (2017) Molecular Systems Biology
Assays: Biphasic control can resist mutant invasion of feedback circuits.