Showing for Sample Type: AB - EI_Fc-Engineered

54 Samples visible to you, out of a total of 54

ID Title UID Name Catalog# Vendor Analyte Clone Fc-variant AminoAcidMutations Description Protocol Scientist Notes
ID Title UID Name Catalog# Vendor Analyte Clone Fc-variant AminoAcidMutations Description Protocol Scientist Notes
38893 AB-220920ALT-1 AB-220920ALT-1 MAb 24c5 4BFab5-Ab-BNP4 Hytest IgG1 24c5 Not specified Not specified Not specified https://fairdomhub.org/sops/724 Eddie Irvine Not specified
38894 AB-220921ALT-1 AB-220921ALT-1 Fc Variant IgG1 Not specified Not specified IgG1 24c5 IgG1 Not specified human IgG1 https://fairdomhub.org/sops/724 Eddie Irvine https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111768/
38895 AB-220920ALT-2 AB-220920ALT-2 Fc Variant IgG2 Not specified Not specified IgG2 24c5 IgG2 Not specified human IgG2 https://fairdomhub.org/sops/724 Eddie Irvine Not specified
38896 AB-220920ALT-3 AB-220920ALT-3 Fc Variant IgG4 Not specified Not specified IgG4 24c5 IgG4 Not specified human IgG4 https://fairdomhub.org/sops/724 Eddie Irvine Not specified
38897 AB-220920ALT-4 AB-220920ALT-4 Fc Variant LALA Not specified Not specified IgG1 24c5 LALA L234A/L235A Lower FcyR binding https://fairdomhub.org/sops/724 Eddie Irvine https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111768/
38898 AB-220920ALT-5 AB-220920ALT-5 Fc Variant LALA LS Not specified Not specified IgG1 24c5 LALA LS L234A/L235A/M428L/N434S Lower FcyR binding; Higher FcRn binding https://fairdomhub.org/sops/724 Eddie Irvine https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855492/
38899 AB-220920ALT-6 AB-220920ALT-6 Fc Variant N297Q Not specified Not specified IgG1 24c5 N297Q N297Q Lower FcyR binding https://fairdomhub.org/sops/724 Eddie Irvine Not specified
38900 AB-220920ALT-7 AB-220920ALT-7 Fc Variant AA LS Not specified Not specified IgG1 24c5 AA LS T307A/E380A/M428L/N434S Higher FcRn binding https://fairdomhub.org/sops/724 Eddie Irvine https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855492/
38901 AB-220920ALT-8 AB-220920ALT-8 Fc Variant QL Not specified Not specified IgG1 24c5 QL T250Q/M428L Higher FcRn binding https://fairdomhub.org/sops/724 Eddie Irvine https://pubmed.ncbi.nlm.nih.gov/14699147/
38902 AB-220920ALT-9 AB-220920ALT-9 Fc Variant QLS Not specified Not specified IgG1 24c5 QLS T250Q/M428L/N434S Higher FcRn binding https://fairdomhub.org/sops/724 Eddie Irvine https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855492/
38903 AB-220920ALT-10 AB-220920ALT-10 Fc Variant YTE Not specified Not specified IgG1 24c5 YTE M252Y/S254T/T256E Lower ADCC; Higher FcRn binding https://fairdomhub.org/sops/724 Eddie Irvine https://pubmed.ncbi.nlm.nih.gov/12391234/
38904 AB-220920ALT-11 AB-220920ALT-11 Fc Variant YTE LS Not specified Not specified IgG1 24c5 YTE LS M252Y/S254T/T256E/M428L/N434S Lower ADCC; Higher FcRn binding https://fairdomhub.org/sops/724 Eddie Irvine https://pubmed.ncbi.nlm.nih.gov/12391234/; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855492/
38905 AB-220920ALT-12 AB-220920ALT-12 Fc Variant E380A Not specified Not specified IgG1 24c5 E380A E380A Higher FcRn binding https://fairdomhub.org/sops/724 Eddie Irvine Not specified
38906 AB-220920ALT-13 AB-220920ALT-13 Fc Variant E380A LS Not specified Not specified IgG1 24c5 E380A LS E380A/M428L/N434S Higher FcRn binding https://fairdomhub.org/sops/724 Eddie Irvine https://pubmed.ncbi.nlm.nih.gov/11096108/; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855492/
38907 AB-220920ALT-14 AB-220920ALT-14 Fc Variant AAA Not specified Not specified IgG1 24c5 AAA T307A/E380A/N434A Higher FcRn binding https://fairdomhub.org/sops/724 Eddie Irvine https://pubmed.ncbi.nlm.nih.gov/11096108/
38908 AB-220920ALT-15 AB-220920ALT-15 Fc Variant DVNH Not specified Not specified IgG1 24c5 DVNH D376V/N434H Higher FcRn binding https://fairdomhub.org/sops/724 Eddie Irvine https://pubmed.ncbi.nlm.nih.gov/17050651/
38909 AB-220920ALT-16 AB-220920ALT-16 Fc Variant MLNS Not specified Not specified IgG1 24c5 MLNS M428L/N434S Higher FcRn binding https://fairdomhub.org/sops/724 Eddie Irvine Not specified
38910 AB-220920ALT-17 AB-220920ALT-17 Fc Variant N434A Not specified Not specified IgG1 24c5 N434A N434A Higher FcRn binding https://fairdomhub.org/sops/724 Eddie Irvine https://pubmed.ncbi.nlm.nih.gov/11096108/
38911 AB-220920ALT-18 AB-220920ALT-18 Fc Variant N434W Not specified Not specified IgG1 24c5 N434W N434W Higher FcRn binding https://fairdomhub.org/sops/724 Eddie Irvine https://pubmed.ncbi.nlm.nih.gov/19494290/
38912 AB-220920ALT-19 AB-220920ALT-19 Fc Variant PINH Not specified Not specified IgG1 24c5 PINH P257I/N434H Higher FcRn binding https://fairdomhub.org/sops/724 Eddie Irvine https://pubmed.ncbi.nlm.nih.gov/17050651/
38913 AB-220920ALT-20 AB-220920ALT-20 Fc Variant P257I LS Not specified Not specified IgG1 24c5 P257I LS P257I/M428L/N434S Higher FcRn binding https://fairdomhub.org/sops/724 Eddie Irvine https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855492/
38914 AB-220920ALT-21 AB-220920ALT-21 Fc Variant PIQI Not specified Not specified IgG1 24c5 PIQI P257I/Q311I Higher FcRn binding https://fairdomhub.org/sops/724 Eddie Irvine https://pubmed.ncbi.nlm.nih.gov/17050651/
38915 AB-220920ALT-22 AB-220920ALT-22 Fc Variant PIQI LS Not specified Not specified IgG1 24c5 PIQI LS P257I/Q311I/M428L/N434S Higher FcRn binding https://fairdomhub.org/sops/724 Eddie Irvine https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855492/
38916 AB-220920ALT-23 AB-220920ALT-23 Fc Variant D376V LS Not specified Not specified IgG1 24c5 D376V LS D376V/M428L/N434S Higher FcRn binding https://fairdomhub.org/sops/724 Eddie Irvine https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855492/; https://pubmed.ncbi.nlm.nih.gov/17050651/
38917 AB-220920ALT-24 AB-220920ALT-24 Fc Variant SELF Not specified Not specified IgG1 24c5 SELF S267E/L328F Higher FcyRIIb binding https://fairdomhub.org/sops/724 Eddie Irvine https://pubmed.ncbi.nlm.nih.gov/18691763/
38918 AB-220920ALT-25 AB-220920ALT-25 Fc Variant SELF LS Not specified Not specified IgG1 24c5 SELF LS S267E/L328F/M428L/N434S Higher FcyRIIb binding; Higher FcRn binding https://fairdomhub.org/sops/724 Eddie Irvine https://pubmed.ncbi.nlm.nih.gov/18691763/; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855492/
38919 AB-220920ALT-26 AB-220920ALT-26 Fc Variant IgG3RH Not specified Not specified IgG1 24c5 IgG3 RH R435H Higher FcRn binding https://fairdomhub.org/sops/724 Eddie Irvine Not specified
38920 AB-220920ALT-27 AB-220920ALT-27 Fc Variant SAEAKA Not specified Not specified IgG1 24c5 SAEAKA S298A/E333A/K334A Higher ADCC https://fairdomhub.org/sops/724 Eddie Irvine https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1389705/; https://pubmed.ncbi.nlm.nih.gov/11096108/
38921 AB-220920ALT-28 AB-220920ALT-28 Fc Variant S324T Not specified Not specified IgG1 24c5 S324T S324T Higher Complement https://fairdomhub.org/sops/724 Eddie Irvine https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2840237/
38922 AB-220920ALT-29 AB-220920ALT-29 Fc Variant S324T LS Not specified Not specified IgG1 24c5 S324T LS S324T/M428L/N434S Higher Complement; Higher FcRn binding https://fairdomhub.org/sops/724 Eddie Irvine https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2840237/; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855492/
38923 AB-220920ALT-30 AB-220920ALT-30 Fc Variant HFST Not specified Not specified IgG1 24c5 HFST H268F/S324T Higher Complement https://fairdomhub.org/sops/724 Eddie Irvine https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2840237/
38924 AB-220920ALT-31 AB-220920ALT-31 Fc Variant HFST LS Not specified Not specified IgG1 24c5 HFST LS H268F/S324T/M428L/N434S Higher Complement; Higher FcRn binding https://fairdomhub.org/sops/724 Eddie Irvine https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2840237/; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855492/
38925 AB-220920ALT-32 AB-220920ALT-32 Fc Variant E345R LS Not specified Not specified IgG1 24c5 E345R LS E345R/M428L/N434S Higher Complement; Higher FcRn binding https://fairdomhub.org/sops/724 Eddie Irvine https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4250092/; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855492/
38926 AB-220920ALT-33 AB-220920ALT-33 Fc Variant SEHFST LS Not specified Not specified IgG1 24c5 SEHFST LS S267E/H268F/S324T/M428L/N434S Higher Complement; Higher FcRn binding https://fairdomhub.org/sops/724 Eddie Irvine https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855492/; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2840237/
38927 AB-220920ALT-34 AB-220920ALT-34 Fc Variant KWES Not specified Not specified IgG1 24c5 KWES K236W/E333S Higher Complement https://fairdomhub.org/sops/724 Eddie Irvine https://pubmed.ncbi.nlm.nih.gov/7543517/
38928 AB-220920ALT-35 AB-220920ALT-35 Fc Variant RGYLS Not specified Not specified IgG1 24c5 RGYLS E345R/E430G/S440Y/M428L/N434S Higher Complement; Higher FcRn binding https://fairdomhub.org/sops/724 Eddie Irvine https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4250092/; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855492/
38929 AB-220920ALT-36 AB-220920ALT-36 Fc Variant ALS Not specified Not specified IgG1 24c5 ALS E333A/M428L/N434S Higher Complement; Higher ADCC; Higher FcRn binding https://fairdomhub.org/sops/724 Eddie Irvine https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855492/
38930 AB-220920ALT-37 AB-220920ALT-37 Fc Variant EFTEA Not specified Not specified IgG1 24c5 EFTEA G236A/S267E/H268F/S324T/I332E Higher ADCC; Higher Phagocytosis; Higher Complement https://fairdomhub.org/sops/724 Eddie Irvine https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2840237/
38931 AB-220920ALT-38 AB-220920ALT-38 Fc Variant EFTEA LS Not specified Not specified IgG1 24c5 EFTEA LS G236A/S267E/H268F/S324T/I332E/M428L/N434S Higher ADCC; Higher Phagocytosis; Higher Complement; Higher FcRn binding https://fairdomhub.org/sops/724 Eddie Irvine https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855492/; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2840237/
38932 AB-220920ALT-39 AB-220920ALT-39 Fc Variant I332E Not specified Not specified IgG1 24c5 I332E I332E Higher ADCC; Higher Phagocytosis https://fairdomhub.org/sops/724 Eddie Irvine https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1389705/
38933 AB-220920ALT-40 AB-220920ALT-40 Fc Variant I332E LS Not specified Not specified IgG1 24c5 I332E LS I332E/M428L/N434S Higher ADCC; Higher Phagocytosis; Higher FcRN binding https://fairdomhub.org/sops/724 Eddie Irvine https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1389705/; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855492/
38934 AB-220920ALT-41 AB-220920ALT-41 Fc Variant SDIE Not specified Not specified IgG1 24c5 SDIE S239D/I332E Higher ADCC; Higher Phagocytosis https://fairdomhub.org/sops/724 Eddie Irvine https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1389705/; https://pubmed.ncbi.nlm.nih.gov/18723496/
38935 AB-220920ALT-42 AB-220920ALT-42 Fc Variant SDIE LS Not specified Not specified IgG1 24c5 SDIE LS S239D/I332E/M428L/N434S Higher ADCC; Higher Phagocytosis; Higher FcRN binding https://fairdomhub.org/sops/724 Eddie Irvine https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1389705/; https://pubmed.ncbi.nlm.nih.gov/18723496/; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855492/
38936 AB-220920ALT-43 AB-220920ALT-43 Fc Variant SDIEAL Not specified Not specified IgG1 24c5 SDIEAL S239D/A330L/I332E Higher ADCC; Higher Phagocytosis https://fairdomhub.org/sops/724 Eddie Irvine https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1389705/; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3187489/
38937 AB-220920ALT-44 AB-220920ALT-44 Fc Variant SDIEAL LS Not specified Not specified IgG1 24c5 SDIEAL LS S2392D/A330L/I332E/M428L/N434S Higher ADCC; Higher Phagocytosis; Higher FcRN binding https://fairdomhub.org/sops/724 Eddie Irvine https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1389705/; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3187489/; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855492/
38938 AB-220920ALT-45 AB-220920ALT-45 Fc Variant SDIEGA Not specified Not specified IgG1 24c5 SDIEGA G236A/S239D/I332E Higher ADCC; Higher Phagocytosis https://fairdomhub.org/sops/724 Eddie Irvine https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3187489/; https://pubmed.ncbi.nlm.nih.gov/18723496/
38939 AB-220920ALT-46 AB-220920ALT-46 Fc Variant SDIEGA LS Not specified Not specified IgG1 24c5 SDIEGA LS G236A/S239D/I332E/M428L/N434S Higher ADCC; Higher Phagocytosis; Higher FcRN binding https://fairdomhub.org/sops/724 Eddie Irvine https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3187489/; https://pubmed.ncbi.nlm.nih.gov/18723496/; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855492/
38940 AB-220920ALT-47 AB-220920ALT-47 Fc Variant SDIESA Not specified Not specified IgG1 24c5 SDIESA S239D/S298A/I332E Higher ADCC; Higher Phagocytosis https://fairdomhub.org/sops/724 Eddie Irvine Not specified
38941 AB-220920ALT-48 AB-220920ALT-48 Fc Variant SDIESA LS Not specified Not specified IgG1 24c5 SDIESA LS S239D/S298A/I332E/M428L/N434S Higher ADCC; Higher Phagocytosis; Higher FcRN binding https://fairdomhub.org/sops/724 Eddie Irvine https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855492/
38942 AB-220920ALT-49 AB-220920ALT-49 Fc Variant SDIEALGA Not specified Not specified IgG1 24c5 SDIEALGA G236A/S239D/A330L/I332E Higher ADCC; Higher Phagocytosis https://fairdomhub.org/sops/724 Eddie Irvine https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341029/
38943 AB-220920ALT-50 AB-220920ALT-50 Fc Variant SDIEALGA LS Not specified Not specified IgG1 24c5 SDIEALGA LS G236A/S239D/A330L/I332E/M428L/N434S Higher ADCC; Higher Phagocytosis; Higher FcRN binding https://fairdomhub.org/sops/724 Eddie Irvine https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341029/; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855492/
38944 AB-220920ALT-51 AB-220920ALT-51 Fc Variant K326W Not specified Not specified IgG1 24c5 K326W K326W Higher Complement; Higher ADCC https://fairdomhub.org/sops/724 Eddie Irvine https://pubmed.ncbi.nlm.nih.gov/10754313/; https://pubmed.ncbi.nlm.nih.gov/11160318/
38945 AB-220920ALT-52 AB-220920ALT-52 Fc Variant E333A Not specified Not specified IgG1 24c5 E333A E333A Higher Complement; Higher ADCC https://fairdomhub.org/sops/724 Eddie Irvine https://pubmed.ncbi.nlm.nih.gov/10754313/; https://pubmed.ncbi.nlm.nih.gov/11160318/
38946 AB-220921ALT-2 AB-220921ALT-2 Fc Variant IgG1 Isotype Not specified Not specified IgG1 24c5 IgG1 Isotype Not specified Not specified https://fairdomhub.org/sops/724 Eddie Irvine Not specified
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