2022-12-08_ Histology Quant., CYP activity, Protein, TG, AUC

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												CYP Activity
		computer based quantitative assessment of Histological staining								TG	Protein Content	[pmol/(mg Protein x min)]				[nmol/(mg Protein x min)]			Caffeine				Midazolam					Codeine
Animal ID	Gp	Total (macro+micro) %	Micro Steaosis Pattern Analysis %	Macro Steaosis Pattern Analysis %	Droplet count %	CYP3A4 %	CYP2E1 %	CYP1A2 %	CYP2D6 %	TG nmol/100mg Liver	Protein Content mg/ml	Ethoxycoumarin-O-Deethylation (ECOD) CYP 1A, 2A, 2B, 2C	Ethoxyresorufin-O-Deethylation (EROD) CYP1A	Pentoxyresorufin-O-Depentylation (PROD) CYP2B	p-Nitrophenol-Hydroxylation (PNPH) CYP2E1	Ethylmorphine-N-Demethylation (EMND) CYP3A	Animal ID	Gp	AUC (hr·ng/ml) Caffeine	C-max	t-half life	t-max	AUC (min·ng/mL) Midazolam	C-max Midazolam (ng/ml)	t 0.5 (hr)	t-max Midazolam (h)	AUC (hr·ng/ml) 1-OH-Midazolam	AUC (min·ng/ml) Codeine	C-max Codeine (ng/ml)	t 0.5 (hr) Codeine	t-max Codeine (h)	AUC (hr·ng/ml) Norcodeine	AUC (hr·ng/ml) Codeine-6-Glucuronide	AUC (hr·ng/ml) Morphine-3-Glucuronide	AUC (hr·ng/ml) Morphine (ng/ml)
MNT-021	Control	0.2	0.14	0.06	0.98	52.92	66.12	58.2	81.48	167.64	71.89	811.03	247.98	42.02	16.5	0.566	MNT-047	Control	1630.224	948.6300963	1.457786	0.868652	14.72803	20.59282934	0.600178	0.357617	57.29573	148.3442	280.3209634	0.44409	0.264551	42.42537	27.66938	287.5279	4.968337
MNT-022	Control	0.24	0.15	0.08	0.41	51.58	67.25	57.47	89.12	92.13	67.35	813.3	259.13	36.53	10.064	0.683	MNT-048	Control	2449.536	1519.642046	1.362252	0.811621	61.25428	72.28955749	0.711075	0.42373	159.8133	146.3766	221.2714957	0.555134	0.330762	61.96162	34.62089	384.1136	6.260965
MNT-023	Control	0.07	0.04	0.03	0.27	58.64	64.09	67.92	85.81	85.32	76.17	794.33	246.71	34.91	9.216	0.597	MNT-049	Control	1844.886	1251.10974	1.242081	0.740039	64.4802	106.7031291	0.507109	0.302148	164.4718	156.5814	224.8617654	0.584358	0.348145	71.17523	26.49182	239.478	3.79727
MNT-024	Control	0.04	0.01	0.02	0.27	66.21	60.53	52.95	68.41	129.38	79.15	645.5	191.87	31.52	7.645	0.554	MNT-050	Control	2073.235	940.1138168	1.942021	1.157031	13.03766	36.62783992	0.298708	0.17793	100.7486	169.2473	293.0336177	0.484682	0.28877	73.34749	34.57607	296.9478	3.756083
MNT-025	Control	0.05	0.02	0.03	0.55	47.94	62.13	61.95	90.6	49.4	73.18	798.8	251.46	38.19	17.034	0.564
MNT-026	Control	0.02	0.01	0.01	0.38	63.52	47.45	61.28	74.43	73.76	70.07	636.57	266.18	38.92	12.609	0.657
MNT-031	2Wks MCD+HFD	82.35	68.69	13.67	8.6	57.7	73.14	64.53	84.31	216.77	63.97	688.22	160.22	40.43	14.568	0.413	MNT-053	2Wks MCD+HFD	781.58	1607.489744	0.408009	0.243164	40.03747	55.18449108	0.608845	0.362695	89.86115	150.9299	273.5232461	0.463057	0.275879	33.81275	20.91369	221.7522	4.722804
MNT-032	2Wks MCD+HFD	63.58	41.33	22.26	9.97	56.35	70.37	70.25	92.52	258.19	64.88	514.32	160.59	44.37	14.178	0.465	MNT-054	2Wks MCD+HFD	1170.619	958.6777289	1.025515	0.611035	27.94247	20.63782343	1.138383	0.67832	107.395	177.6778	289.2380329	0.515503	0.307129	39.26078	37.29251	257.0427	6.114801
MNT-033	2Wks MCD+HFD	77.75	46.49	31.28	9.94	89.09	74.86	90.53	94.61	192.66	64.1	272.38	243.39	34.7	16.804	0.569	MNT-055	2Wks MCD+HFD	1184.112	1200.244889	0.827978	0.493262	34.8706	23.83596367	1.231999	0.733984	131.1952	126.7072	241.1356642	0.440946	0.262793	27.99975	11.99923	192.1109	3.551135
MNT-034	2Wks MCD+HFD	51.34	33.58	17.76	8	67.71	75.96	73.12	74.13	261.38	69.16	616.67	231.21	40.97	17.15	0.573	MNT-056	2Wks MCD+HFD	1161.537	1799.734223	0.541602	0.322656	17.07241	20.56498317	0.696669	0.415039	141.1625	110.7632	191.8878811	0.4844	0.288574	23.5872	17.63856	193.0995	2.485014
MNT-035	2Wks MCD+HFD	84.74	58.78	25.96	11.26	60.78	66.86	68.17	95.63	273.26	64.1	764.26	205.94	43.27	18.315	0.619	MNT-057	2Wks MCD+HFD	1434.464	1823.080146	0.660301	0.393359	66.69743	54.65171026	1.024946	0.610742	96.9956	169.5294	276.5727704	0.514377	0.306543	35.6259	40.30173	291.511	5.102712
MNT-036	2Wks MCD+HFD	55.84	42.47	13.37	7.97	62.05	57.86	77.96	92.87	314.35	63.84	786.74	222.01	45.23	14.029	0.547	MNT-058	2Wks MCD+HFD	983.92	569.771068	1.465396	0.873047	40.32903	41.33711735	0.818771	0.487891		129.136	238.4726598	0.454429	0.270703	30.05477	9.527005	259.3622	6.211163
MNT-041	4Wks MCD+HFD	56.5	18.21	38.29	11.61	49.41	66.65	52.02	86.78	222.14	65.4	783.57	173.95	41.11	27.02	0.404	MNT-059	4Wks MCD+HFD	1886.053	1300.580468	1.220951	0.727539	78.37385	101.0175116	0.651074	0.387891	148.8712	155.6358	261.9291833	0.498621	0.297168	36.4529	42.46653	318.8299	4.453484
MNT-042	4Wks MCD+HFD	62.81	28.45	34.35	12.74	49.94	68.45	57.67	76.53	467.71	69.16	596.38	176.87	36.78	15.225	0.489	MNT-060	4Wks MCD+HFD	2697.618	1811.779362	1.254498	0.747461	53.88873	30.8031504	1.486001	0.885449	144.2567	187.4097	265.1423027	0.593151	0.353418	47.28853	26.83506	304.6304	4.650659
MNT-043	4Wks MCD+HFD	90.53	46.35	44.18	16.13	65.1	73.02	77.2	79.52	269.68	64.36	575.47	170.19	43.89	26.139	0.534	MNT-061	4Wks MCD+HFD	2621.167	2119.408886	1.038773	0.618945	107.9256	122.373609	0.740111	0.441016	249.2037	209.668	283.6939501	0.620205	0.369531	43.09417	47.39604	363.6123	8.716874
MNT-044	4Wks MCD+HFD	77.71	41.71	35.99	12.1	59.73	67.44	88.81	96.08	217.05	62.67	344.41	188.93	36.1	22.208	0.591	MNT-062	4Wks MCD+HFD	2263.17	1297.863573	1.480803	0.882227	65.35138	78.85306408	0.695486	0.414453	133.131	193.5213	292.216797	0.555742	0.331152	42.88558	50.40843	374.9067	7.339616
MNT-045	4Wks MCD+HFD	67.74	36.11	31.64	12.43	45.25	68.65	51.37	95	301.46	62.16	774.73	214.09	36.03	21.615	0.391	MNT-063	4Wks MCD+HFD	2545.226	2047.507922	1.044138	0.622168	49.13094	20.92956422	2.109913	1.257129	124.11	180.6172	233.0996055	0.650238	0.387402	39.26436	47.72895	354.9491	5.375443
MNT-046	4Wks MCD+HFD	84.65	29.46	55.19	18.32	51.77	71.7	62.52	94.79	298.73	66.05	702.1	178.36	39.52	23.456	0.512	MNT-064	4Wks MCD+HFD	2587.83	2422.846209	0.896513	0.53418	104.1709	97.74561581	0.894526	0.533008	210.1616	213.5032	320.8608301	0.558391	0.332715	47.92258	73.26023	387.1657	6.562773