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Drug name | Commercial Drug used | Dose; Reference | Drug name | Concentration Stock solution (mg/1000µl) | Dose mg/ 1000g body weight | drug preparation for 100gr of mouse (gm) | needed volume of stock solution (µl) | concentration of drug in injected volume (mg/ml) | injection volume (µl)/g mouse/drug | total volume of drug solution for 100 gr of mouse | Added water (µl) | body weight of mouse (gr) | vol drug dilution per mouse (ml) | cocktail form of injection | |
i.p; Single injection in right side of the abdomen | Codeine | (Codeine.phosphate.hemihydrate)_(5mg/1000µl) | (Schenk, 2017, DOI: 10.1038/s41598-017-04574-z, | Codeine | 5 | 2 | 100 | 40 | 1 | 2 | 200 | 160 | 30 | 60 | 180 |
Caffeine | Citrate de cafeine cooper (Caffeine citrate 25 mg/1000µl) | Caffeine | 25 | 5 | 100 | 20 | 2.5 | 2 | 200 | 180 | 30 | 60 | 180 | ||
Midazolam | Midazolam B. Braun (5mg/1000µl) | Midazolam | 5 | 2 | 100 | 40 | 1 | 2 | 200 | 160 | 30 | 60 | 180 | ||
Total volume of drug solution for 100gr of mouse | 600 | ||||||||||||||
Total volume of cocktail | Entry nr. | Body weight of mouse (gr) | Total volume of cocktail (µl)/mouse | Truely injected volume (ml) | Calculated error (%) | ||||||||||
Date | Animal-ID | 600 | |||||||||||||
2021-04-21T0:0:0+0000 | MNT-011 | 1306 | 28.5 | 171 | 170 | 0.005847953216374269 | |||||||||
2021-04-21T0:0:0+0000 | MNT-012 | 1309 | 28.5 | 171 | 170 | 0.005847953216374269 | |||||||||
2021-04-26T0:0:0+0000 | MNT-047 | 1338 | 30.77 | 184.62 | 185 | 0.0020582818762864014 | |||||||||
2021-04-26T0:0:0+0000 | MNT-048 | 1339 | 30.71 | 184.26 | 185 | 0.004016064257028162 | |||||||||
2021-04-30T0:0:0+0000 | MNT-049 | 1340 | 26.75 | 160.5 | 160 | 0.003115264797507788 | |||||||||
2021-04-30T0:0:0+0000 | MNT-050 | 1341 | 30.32 | 181.92 | 182.5 | 0.0031882145998241673 | |||||||||
2021-05-03T0:0:0+0000 | MNT-053 | 1344 | 31.41 | 188.46 | 187.5 | 0.005093919134033789 | |||||||||
2021-05-03T0:0:0+0000 | MNT-054 | 1345 | 31.38 | 188.28 | 187.5 | 0.004142766093052906 | |||||||||
2021-05-05T0:0:0+0000 | MNT-055 | 1346 | 30.41 | 182.46 | 182.5 | 2.1922613175486157E-4 | |||||||||
2021-05-05T0:0:0+0000 | MNT-056 | 1347 | 29.2 | 175.2 | 175 | 0.0011415525114154602 | |||||||||
2021-05-07T0:0:0+0000 | MNT-057 | 1348 | 34.46 | 206.76 | 207.5 | 0.003579028825691667 | |||||||||
2021-05-07T0:0:0+0000 | MNT-058 | 1349 | 29.19 | 175.14 | 175 | 7.993605115906496E-4 | |||||||||
2021-05-17T0:0:0+0000 | MNT-059 | 1350 | 32.3 | 193.8 | 195 | 0.006191950464396226 | |||||||||
2021-05-17T0:0:0+0000 | MNT-060 | 1351 | 32.75 | 196.5 | 197.5 | 0.005089058524173028 | |||||||||
2021-05-19T0:0:0+0000 | MNT-061 | 1352 | 33.1 | 198.6 | 197.5 | 0.005538771399798562 | |||||||||
2021-05-19T0:0:0+0000 | MNT-062 | 1353 | 34.37 | 206.22 | 205 | 0.005916012025991654 | |||||||||
2021-05-21T0:0:0+0000 | MNT-063 | 1354 | 31.7 | 190.2 | 190 | 0.0010515247108306449 | |||||||||
2021-05-21T0:0:0+0000 | MNT-064 | 1355 | 39.4 | 236.4 | 237.5 | 0.00465313028764803 | |||||||||
2021-05-26T0:0:0+0000 | MNT-051 | 1342 | 29.8 | 178.8 | 180 | 0.00671140939597309 | |||||||||
2021-05-26T0:0:0+0000 | MNT-052 | 1343 | 32.18 | 193.08 | 192.5 | 0.003003936192251981 | |||||||||
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Normal food | Fatty food for 2wks | Fatty food for 4wks | druig injection start | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Fat food feeding for Stea Pk_MAA (19.04.2021-15.05.2021) | Change the food completely on Monday and Thursday | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Store fatty food in dark! | First, weigh the ramining food, then fill the food container up to (gm) | 50 | gm | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Wk-01 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Serial Nr | Animal Exp. ID | Entry-number | Srain | Type of food | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Ear Pinch | Company | 2021-04-19T0:0:0+0000 | 2021-04-20T0:0:0+0000 | 2021-04-21T0:0:0+0000 | 2021-04-22T0:0:0+0000 | 2021-04-23T0:0:0+0000 | 2021-04-24T0:0:0+0000 | 2021-04-25T0:0:0+0000 | 2021-04-26T0:0:0+0000 | 2021-04-27T0:0:0+0000 | 2021-04-28T0:0:0+0000 | 2021-04-29T0:0:0+0000 | 2021-04-30T0:0:0+0000 | 2021-05-01T0:0:0+0000 | 2021-05-02T0:0:0+0000 | 2021-05-03T0:0:0+0000 | 2021-05-04T0:0:0+0000 | 2021-05-05T0:0:0+0000 | 2021-05-06T0:0:0+0000 | 2021-05-07T0:0:0+0000 | 2021-05-08T0:0:0+0000 | 2021-05-09T0:0:0+0000 | 2021-05-10T0:0:0+0000 | 2021-05-11T0:0:0+0000 | 2021-05-12T0:0:0+0000 | 2021-05-13T0:0:0+0000 | 2021-05-14T0:0:0+0000 | 2021-05-15T0:0:0+0000 | 2021-05-16T0:0:0+0000 | 2021-05-17T0:0:0+0000 | 2021-05-18T0:0:0+0000 | 2021-05-19T0:0:0+0000 | 2021-05-20T0:0:0+0000 | 2021-05-21T0:0:0+0000 | 2021-05-22T0:0:0+0000 | 2021-05-23T0:0:0+0000 | 2021-05-24T0:0:0+0000 | 2021-05-25T0:0:0+0000 | 2021-05-26T0:0:0+0000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
body Wt | remaining food | food Consumed | body Wt | remaining food | food Consumed | body Wt | remaining food | food Consumed | body Wt | remaining food | food Consumed | body Wt | remaining food | food Consumed | body Wt | remaining food | food Consumed | body Wt | remaining food | food Consumed | body Wt | remaining food | food Consumed | body Wt | remaining food | food Consumed | body Wt | remaining food | food Consumed | body Wt | remaining food | food Consumed | body Wt | remaining food | food Consumed | body Wt | remaining food | food Consumed | body Wt | remaining food | food Consumed | body Wt | remaining food | food Consumed | body Wt | remaining food | food Consumed | body Wt | remaining food | food Consumed | body Wt | remaining food | food Consumed | body Wt | remaining food | food Consumed | body Wt | remaining food | food Consumed | body Wt | remaining food | food Consumed | body Wt | remaining food | food Consumed | body Wt | remaining food | food Consumed | body Wt | remaining food | food Consumed | body Wt | remaining food | food Consumed | body Wt | remaining food | food Consumed | body Wt | remaining food | food Consumed | body Wt | remaining food | food Consumed | body Wt | remaining food | food Consumed | body Wt | remaining food | food Consumed | body Wt | remaining food | food Consumed | body Wt | remaining food | food Consumed | ||||||||||||||||||||||||||||
1 | MNT-047 | 1338 | Ohne | C57BL/6J | Janvier | Normal food | 30.4 | 25 | x | 31.24 | 21.25 | 3.75 | 28.83 | 21.65 | 3.3500000000000014 | 31.28 | 21.725 | 3.2749999999999986 | 30.48 | 21.275 | 3.7250000000000014 | 30.36 | 21.38 | 3.620000000000001 | 30.57 | 21.555 | 3.4450000000000003 | 30.77 | 22.28 | 2.719999999999999 | Pk and sacrifice | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
2 | MNT-048 | 1339 | 1Li | C57BL/6J | Janvier | Normal food | 30.24 | 25 | x | 31.4 | 21.25 | 3.75 | 30.45 | 21.65 | 3.3500000000000014 | 30.37 | 21.725 | 3.2749999999999986 | 30.76 | 21.275 | 3.7250000000000014 | 30.46 | 21.38 | 3.620000000000001 | 31.57 | 21.555 | 3.4450000000000003 | 30.71 | 22.28 | 2.719999999999999 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
3 | MNT-049 | 1340 | Ohne | C57BL/6J | Janvier | Normal food | 27.86 | 25 | x | 27.72 | 21.25 | 3.75 | 26.5 | 21.725 | 3.2749999999999986 | 27.02 | 21.325 | 3.6750000000000007 | 26.52 | 21.655 | 3.344999999999999 | 26.51 | 21.53 | 3.469999999999999 | 26.64 | 21.855 | 3.1449999999999996 | 27.46 | 20.98 | 4.02 | 27.57 | 21.45 | 3.5500000000000007 | 26.92 | 21.425 | 3.5749999999999993 | 26.92 | 22.31 | 2.6900000000000013 | 26.75 | 22.065 | 2.9349999999999987 | Pk and sacrifice | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
4 | MNT-050 | 1341 | 1Li | C57BL/6J | Janvier | Normal food | 32.23 | 25 | x | 31.52 | 21.25 | 3.75 | 30.3 | 21.725 | 3.2749999999999986 | 31.58 | 21.325 | 3.6750000000000007 | 30.34 | 21.655 | 3.344999999999999 | 29.9 | 21.53 | 3.469999999999999 | 29.56 | 21.855 | 3.1449999999999996 | 30.24 | 20.98 | 4.02 | 30.81 | 21.45 | 3.5500000000000007 | 30.29 | 21.425 | 3.5749999999999993 | 29.98 | 22.31 | 2.6900000000000013 | 30.32 | 22.065 | 2.9349999999999987 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
5 | MNT-051 | 1342 | Ohne | C57BL/6J | Janvier | Normal food | 31.18 | 25 | x | 31.35 | 21.25 | 3.75 | 30.8 | 21.77 | 3.2300000000000004 | 31.4 | 21.6 | 3.3999999999999986 | 30.91 | 21.17 | 3.8299999999999983 | 30.59 | 21.535 | 3.465 | 31.65 | 21.53 | 3.469999999999999 | 31.42 | 21.47 | 3.530000000000001 | 31.85 | 21.13 | 3.870000000000001 | 30.9 | 21.85 | 3.1499999999999986 | 31.25 | 22.005 | 2.995000000000001 | 31.23 | 22.045 | 2.9549999999999983 | 30.13 | 22.015 | 2.9849999999999994 | 31.53 | 22.02 | 2.9800000000000004 | 30.57 | 22.02 | 2.9800000000000004 | 30.76 | 22.05 | 2.9499999999999993 | 30.93 | 21.78 | 3.219999999999999 | 31.02 | 21.985 | 3.0150000000000006 | 30.42 | 22.005 | 2.995000000000001 | 30.18 | 21.77 | 3.2300000000000004 | 29.69 | 21.67 | 3.3299999999999983 | 30.82 | 21.3 | 3.6999999999999993 | 31.34 | 22.12 | 2.879999999999999 | 30.85 | 21.5 | 3.5 | 30.64 | 21.8 | 3.1999999999999993 | 30 | 22.235 | 2.7650000000000006 | 30.28 | 22.005 | 2.995000000000001 | 29.47 | 21.915 | 3.085000000000001 | 30.07 | 21.875 | 3.125 | 30.16 | 21.86 | 3.1400000000000006 | 30.41 | 21.905 | 3.094999999999999 | 30.3 | 21.94 | 3.0599999999999987 | 30.32 | 22.37 | 2.629999999999999 | 29.69 | 22.855 | 2.1449999999999996 | 30 | 20.74 | 4.260000000000002 | 30 | 23.325 | 1.6750000000000007 | 31 | 21.86 | 3.1400000000000006 | 29.8 | 22.08 | 2.9200000000000017 | |||
6 | MNT-052 | 1343 | 1Li | C57BL/6J | Janvier | Normal food | 32.78 | 25 | x | 32.49 | 21.25 | 3.75 | 32.05 | 21.77 | 3.2300000000000004 | 32.42 | 21.6 | 3.3999999999999986 | 32.9 | 21.17 | 3.8299999999999983 | 31.52 | 21.535 | 3.465 | 32.47 | 21.53 | 3.469999999999999 | 32.02 | 21.47 | 3.530000000000001 | 32.91 | 21.13 | 3.870000000000001 | 32.09 | 21.85 | 3.1499999999999986 | 32.27 | 22.005 | 2.995000000000001 | 31.98 | 22.045 | 2.9549999999999983 | 32 | 22.015 | 2.9849999999999994 | 32.74 | 22.02 | 2.9800000000000004 | 31.97 | 22.02 | 2.9800000000000004 | 32.85 | 22.05 | 2.9499999999999993 | 33.1 | 21.78 | 3.219999999999999 | 32.39 | 21.985 | 3.0150000000000006 | 32.38 | 22.005 | 2.995000000000001 | 32.11 | 21.77 | 3.2300000000000004 | 32.35 | 21.67 | 3.3299999999999983 | 33.22 | 21.3 | 3.6999999999999993 | 33.04 | 22.12 | 2.879999999999999 | 33.15 | 21.5 | 3.5 | 32.22 | 21.8 | 3.1999999999999993 | 32.6 | 22.235 | 2.7650000000000006 | 32.6 | 22.005 | 2.995000000000001 | 31.79 | 21.915 | 3.085000000000001 | 32.1 | 21.875 | 3.125 | 32.53 | 21.86 | 3.1400000000000006 | 32.1 | 21.905 | 3.094999999999999 | 32.47 | 21.94 | 3.0599999999999987 | 32.47 | 22.37 | 2.629999999999999 | 31.9 | 22.855 | 2.1449999999999996 | 32 | 20.74 | 4.260000000000002 | 32 | 23.325 | 1.6750000000000007 | 32 | 21.86 | 3.1400000000000006 | 32.18 | 22.08 | 2.9200000000000017 | |||
7 | MNT-053 | 1344 | Ohne | C57BL/6J | Janvier | 2Wks MCD+HFD | 30.8 | 25 | x | 31.03 | 20.835 | 4.164999999999999 | 30.6 | 21.525 | 3.4750000000000014 | 30.99 | 21.45 | 3.5500000000000007 | 31.53 | 20.75 | 4.25 | 31.34 | 21.17 | 3.8299999999999983 | 31.55 | 21.33 | 3.6700000000000017 | 31.57 | 21.665 | 3.335000000000001 | 31.93 | 21.015 | 3.9849999999999994 | 31.47 | 21.845 | 3.155000000000001 | 31.7 | 21.835 | 3.164999999999999 | 32.16 | 19.865 | 5.135000000000002 | 31.93 | 21.375 | 3.625 | 31.97 | 22.29 | 2.710000000000001 | 31.41 | 21.73 | 3.2699999999999996 | PK and sacrifice | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
8 | MNT-054 | 1345 | 1Li | C57BL/6J | Janvier | 2Wks MCD+HFD | 29.96 | 25 | x | 30.67 | 20.835 | 4.164999999999999 | 30.37 | 21.525 | 3.4750000000000014 | 30.49 | 21.45 | 3.5500000000000007 | 30.7 | 20.75 | 4.25 | 30.82 | 21.17 | 3.8299999999999983 | 31.02 | 21.33 | 3.6700000000000017 | 31.16 | 21.665 | 3.335000000000001 | 31.06 | 21.015 | 3.9849999999999994 | 30.97 | 21.845 | 3.155000000000001 | 31.19 | 21.835 | 3.164999999999999 | 31.23 | 19.865 | 5.135000000000002 | 30.88 | 21.375 | 3.625 | 31.19 | 22.29 | 2.710000000000001 | 31.38 | 21.73 | 3.2699999999999996 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
9 | MNT-055 | 1346 | 1Li | C57BL/6J | Janvier | 2Wks MCD+HFD | 30.75 | 25 | x | 31 | 21.225 | 3.7749999999999986 | 37.39 | 21.1 | 3.8999999999999986 | 32.45 | 20.465 | 4.535 | 32.26 | 20.87 | 4.129999999999999 | 30.57 | 20.81 | 4.190000000000001 | 31.02 | 20.975 | 4.024999999999999 | 30.37 | 21.48 | 3.5199999999999996 | 31.04 | 20.93 | 4.07 | 30.42 | 21.76 | 3.2399999999999984 | 30.42 | 21.79 | 3.210000000000001 | 30.37 | 20.84 | 4.16 | 30.6 | 20.88 | 4.120000000000001 | 30.61 | 22.1 | 2.8999999999999986 | 30.55 | 21.28 | 3.719999999999999 | 30.66 | 21.08 | 3.9200000000000017 | 30.14 | 21.6 | 3.3999999999999986 | PK and sacrifice | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
10 | MNT-056 | 1347 | Ohne | C57BL/6J | Janvier | 2Wks MCD+HFD | 28.45 | 25 | x | 28.9 | 21.225 | 3.7749999999999986 | 28.85 | 21.1 | 3.8999999999999986 | 29.15 | 20.465 | 4.535 | 29.2 | 20.87 | 4.129999999999999 | 28.86 | 20.81 | 4.190000000000001 | 28.62 | 20.975 | 4.024999999999999 | 28.55 | 21.48 | 3.5199999999999996 | 28.89 | 20.93 | 4.07 | 28.62 | 21.76 | 3.2399999999999984 | 29.12 | 21.79 | 3.210000000000001 | 29.13 | 20.84 | 4.16 | 29.71 | 20.88 | 4.120000000000001 | 29.07 | 22.1 | 2.8999999999999986 | 28.93 | 21.28 | 3.719999999999999 | 29.26 | 21.08 | 3.9200000000000017 | 29.2 | 21.6 | 3.3999999999999986 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
11 | MNT-057 | 1348 | Ohne | C57BL/6J | Janvier | 2Wks MCD+HFD | 29.73 | 25 | x | 29.8 | 21.365 | 3.6350000000000016 | 29.942 | 20.67 | 4.329999999999998 | 29.61 | 20.97 | 4.030000000000001 | 29.48 | 21.365 | 3.6350000000000016 | 30.06 | 19.595 | 5.405000000000001 | 30.62 | 21.185 | 3.8150000000000013 | 30.91 | 21.335 | 3.664999999999999 | 31.22 | 19.49 | 5.510000000000002 | 31.49 | 20.9 | 4.100000000000001 | 31.65 | 21.49 | 3.5100000000000016 | 32.6 | 19.49 | 5.510000000000002 | 32.76 | 20.48 | 4.52 | 32.74 | 21.92 | 3.0799999999999983 | 32.92 | 21.27 | 3.7300000000000004 | 33.96 | 20.62 | 4.379999999999999 | 33.51 | 21.82 | 3.1799999999999997 | 33.62 | 22.42 | 2.5799999999999983 | 34.46 | 20.72 | 4.280000000000001 | PK and sacrifice | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
12 | MNT-058 | 1349 | 1li | C57BL/6J | Janvier | 2Wks MCD+HFD | 32.37 | 25 | x | 33.91 | 21.365 | 3.6350000000000016 | 35.45 | 20.67 | 4.329999999999998 | 36.82 | 20.97 | 4.030000000000001 | 34.65 | 21.365 | 3.6350000000000016 | 33.94 | 19.595 | 5.405000000000001 | 33.36 | 21.185 | 3.8150000000000013 | 32.49 | 21.335 | 3.664999999999999 | 32.4 | 20.35 | 4.649999999999999 | 31.12 | 21.45 | 3.5500000000000007 | 31.18 | 21.23 | 3.7699999999999996 | 30.64 | 21.21 | 3.789999999999999 | 30.35 | 21.22 | 3.780000000000001 | 30.06 | 21.56 | 3.4400000000000013 | 29.5 | 21 | 4 | 29.58 | 20.25 | 4.75 | 29.5 | 20.83 | 4.170000000000002 | 29.25 | 21.44 | 3.5599999999999987 | 29.19 | 19.72 | 5.280000000000001 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
13 | MNT-059 | 1350 | Ohne | C57BL/6J | Janvier | 4Wks MCD+HFD | 30.49 | 25 | x | 31.91 | 20.27 | 4.73 | 31.03 | 21.575 | 3.4250000000000007 | 31.9 | 21.42 | 3.5799999999999983 | 31.87 | 21.135 | 3.8649999999999984 | 31.5 | 21.365 | 3.6350000000000016 | 31.58 | 21.845 | 3.155000000000001 | 31.33 | 22.235 | 2.7650000000000006 | 31.53 | 21.29 | 3.710000000000001 | 31.2 | 22.335 | 2.664999999999999 | 32.25 | 22.24 | 2.7600000000000016 | 32.44 | 21.26 | 3.7399999999999984 | 31.37 | 21.685 | 3.3150000000000013 | 31.51 | 22.32 | 2.6799999999999997 | 32.22 | 21.675 | 3.3249999999999993 | 32.22 | 20.99 | 4.010000000000002 | 32.14 | 21.955 | 3.0450000000000017 | 31.9 | 21.95 | 3.0500000000000007 | 32.56 | 20.98 | 4.02 | 32.49 | 21.73 | 3.2699999999999996 | 32.26 | 21.785 | 3.215 | 31.95 | 22.305 | 2.6950000000000003 | 32.82 | 20.78 | 4.219999999999999 | 32.65 | 21.845 | 3.155000000000001 | 32.93 | 21.805 | 3.1950000000000003 | 32.14 | 20.455 | 4.545000000000002 | 32.86 | 21.8 | 3.1999999999999993 | 32.52 | 21.95 | 3.0500000000000007 | 32.3 | 22.455 | 2.5450000000000017 | PK and sacrifice | |||||||||||||||||||||||||||||
14 | MNT-060 | 1351 | 1Li | C57BL/6J | Janvier | 4Wks MCD+HFD | 30.83 | 25 | x | 31.24 | 20.27 | 4.73 | 30.9 | 21.575 | 3.4250000000000007 | 32.06 | 21.42 | 3.5799999999999983 | 31.76 | 21.135 | 3.8649999999999984 | 31.9 | 21.365 | 3.6350000000000016 | 31.76 | 21.845 | 3.155000000000001 | 31.65 | 22.235 | 2.7650000000000006 | 31.74 | 21.29 | 3.710000000000001 | 31.51 | 22.335 | 2.664999999999999 | 31.94 | 22.24 | 2.7600000000000016 | 31.77 | 21.26 | 3.7399999999999984 | 32.21 | 21.685 | 3.3150000000000013 | 32.04 | 22.32 | 2.6799999999999997 | 32.49 | 21.675 | 3.3249999999999993 | 32.45 | 20.99 | 4.010000000000002 | 32.65 | 21.955 | 3.0450000000000017 | 32.65 | 21.95 | 3.0500000000000007 | 32.95 | 20.98 | 4.02 | 32.33 | 21.73 | 3.2699999999999996 | 32.63 | 21.785 | 3.215 | 32.56 | 22.305 | 2.6950000000000003 | 33.25 | 20.78 | 4.219999999999999 | 33.23 | 21.845 | 3.155000000000001 | 32.19 | 21.805 | 3.1950000000000003 | 33.65 | 20.455 | 4.545000000000002 | 33.27 | 21.8 | 3.1999999999999993 | 33 | 21.95 | 3.0500000000000007 | 32.75 | 22.455 | 2.5450000000000017 | ||||||||||||||||||||||||||||||
15 | MNT-061 | 1352 | Ohne | C57BL/6J | Janvier | 4Wks MCD+HFD | 29.95 | 25 | x | 30.85 | 21.53 | 3.469999999999999 | 30.4 | 21.59 | 3.41 | 30.96 | 20.44 | 4.559999999999999 | 30.93 | 20.91 | 4.09 | 30.4 | 21.25 | 3.75 | 31.09 | 21.835 | 3.164999999999999 | 31.35 | 21.51 | 3.4899999999999984 | 32.69 | 21.19 | 3.8099999999999987 | 31.05 | 22.17 | 2.8299999999999983 | 31.4 | 22.56 | 2.4400000000000013 | 31.42 | 21.725 | 3.2749999999999986 | 31.4 | 21.535 | 3.465 | 31.35 | 22.955 | 2.0450000000000017 | 31.21 | 22.125 | 2.875 | 31.78 | 21.63 | 3.370000000000001 | 31.32 | 22.425 | 2.5749999999999993 | 31.6 | 22.2 | 2.8000000000000007 | 31.76 | 21.38 | 3.620000000000001 | 31.63 | 21.92 | 3.0799999999999983 | 31.95 | 22.05 | 2.9499999999999993 | 31.74 | 21.985 | 3.0150000000000006 | 32.23 | 21.725 | 3.2749999999999986 | 32.37 | 22.21 | 2.789999999999999 | 32.32 | 21.51 | 3.4899999999999984 | 33.18 | 20.965 | 4.035 | 33.1 | 22.23 | 2.7699999999999996 | 32.8 | 21.54 | 3.460000000000001 | 31.56 | 22.375 | 2.625 | 33.21 | 21.235 | 3.7650000000000006 | 33.1 | 21.8 | 3.1999999999999993 | PK and sacrifice | |||||||||||||||||||||||
16 | MNT-062 | 1353 | 1Li | C57BL/6J | Janvier | 4Wks MCD+HFD | 30.98 | 25 | x | 31.12 | 21.53 | 3.469999999999999 | 30.34 | 21.59 | 3.41 | 31.61 | 20.44 | 4.559999999999999 | 31.66 | 20.91 | 4.09 | 31.6 | 21.25 | 3.75 | 32.18 | 21.835 | 3.164999999999999 | 32.08 | 21.51 | 3.4899999999999984 | 32.91 | 21.19 | 3.8099999999999987 | 32.33 | 22.17 | 2.8299999999999983 | 32.45 | 22.56 | 2.4400000000000013 | 32.63 | 21.725 | 3.2749999999999986 | 32.82 | 21.535 | 3.465 | 32.42 | 22.955 | 2.0450000000000017 | 32.35 | 22.125 | 2.875 | 32.6 | 21.63 | 3.370000000000001 | 32.41 | 22.425 | 2.5749999999999993 | 32.45 | 22.2 | 2.8000000000000007 | 32.8 | 21.38 | 3.620000000000001 | 32.6 | 21.92 | 3.0799999999999983 | 32.25 | 22.05 | 2.9499999999999993 | 32.59 | 21.985 | 3.0150000000000006 | 32.95 | 21.725 | 3.2749999999999986 | 32.43 | 22.21 | 2.789999999999999 | 32.73 | 21.51 | 3.4899999999999984 | 33.52 | 20.965 | 4.035 | 33.42 | 22.23 | 2.7699999999999996 | 33.83 | 21.54 | 3.460000000000001 | 33.53 | 22.375 | 2.625 | 34.12 | 21.235 | 3.7650000000000006 | 34.37 | 21.8 | 3.1999999999999993 | ||||||||||||||||||||||||
17 | MNT-063 | 1354 | Ohne | C57BL/6J | Janvier | 4Wks MCD+HFD | 26.1 | 25 | x | 26.2 | 21.965 | 3.035 | 26.03 | 21.39 | 3.6099999999999994 | 26.75 | 21.14 | 3.8599999999999994 | 26.69 | 20.965 | 4.035 | 27.59 | 19.5 | 5.5 | 28.01 | 21.19 | 3.8099999999999987 | 27.76 | 21.175 | 3.8249999999999993 | 27.65 | 20.645 | 4.355 | 28.37 | 21.045 | 3.9549999999999983 | 28.54 | 21.865 | 3.1350000000000016 | 28.43 | 20.98 | 4.02 | 28.15 | 21.315 | 3.6849999999999987 | 28.17 | 22.29 | 2.710000000000001 | 28.67 | 21.08 | 3.9200000000000017 | 29.04 | 21.565 | 3.4349999999999987 | 28.79 | 22.11 | 2.8900000000000006 | 28.8 | 21.91 | 3.09 | 29.17 | 20.81 | 4.190000000000001 | 29.7 | 21.11 | 3.8900000000000006 | 29.03 | 22.085 | 2.914999999999999 | 29.22 | 21.78 | 3.219999999999999 | 29.72 | 20.785 | 4.215 | 30.16 | 21.165 | 3.835000000000001 | 29.78 | 21.595 | 3.405000000000001 | 30.24 | 20.865 | 4.135000000000002 | 30.65 | 21.15 | 3.8500000000000014 | 31.25 | 19.115 | 5.885000000000002 | 30.58 | 22.685 | 2.3150000000000013 | 30.86 | 21.515 | 3.4849999999999994 | 30.71 | 22.095 | 2.905000000000001 | 30.59 | 21.825 | 3.1750000000000007 | 31.7 | 20.54 | 4.460000000000001 | PK and sacrifice | |||||||||||||||||
18 | MNT-064 | 1355 | 1Li | C57BL/6J | Janvier | 4Wks MCD+HFD | 31.35 | 25 | x | 31.65 | 21.965 | 3.035 | 31.69 | 21.39 | 3.6099999999999994 | 32.56 | 21.14 | 3.8599999999999994 | 32.65 | 20.965 | 4.035 | 34.23 | 19.5 | 5.5 | 34.8 | 21.19 | 3.8099999999999987 | 34.65 | 21.175 | 3.8249999999999993 | 35.25 | 20.645 | 4.355 | 35.41 | 21.045 | 3.9549999999999983 | 35.62 | 21.865 | 3.1350000000000016 | 36.18 | 20.98 | 4.02 | 36 | 21.315 | 3.6849999999999987 | 26.35 | 22.29 | 2.710000000000001 | 36.65 | 21.08 | 3.9200000000000017 | 36.89 | 21.565 | 3.4349999999999987 | 36.53 | 22.11 | 2.8900000000000006 | 36.3 | 21.91 | 3.09 | 36.33 | 20.81 | 4.190000000000001 | 36.79 | 21.11 | 3.8900000000000006 | 36.68 | 22.085 | 2.914999999999999 | 36.65 | 21.78 | 3.219999999999999 | 37.28 | 20.785 | 4.215 | 37.38 | 21.165 | 3.835000000000001 | 37.24 | 21.595 | 3.405000000000001 | 38.11 | 20.865 | 4.135000000000002 | 37.67 | 21.15 | 3.8500000000000014 | 39.38 | 19.115 | 5.885000000000002 | 38.01 | 22.685 | 2.3150000000000013 | 37.94 | 21.515 | 3.4849999999999994 | 37.22 | 22.095 | 2.905000000000001 | 38.02 | 21.825 | 3.1750000000000007 | 39.4 | 20.54 | 4.460000000000001 | ||||||||||||||||||
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Run | Date | Species | µ | Animal ID | Entry no | Treatmnt | Tube | Date of birth-year (w) | used before | Protocol number | Age (month) | Weight (gr) | Restrainer | blood volume (µl) | comments_Filling level/Problems | Time point | Day time of sampling | Scoring result after last blood sample | ||
1 | 2021-04-21T0:0:0+0000 | Mouse | Bl6 | MNT-011 | 1306 | Drug coktails (Midazolam 2mg/kg, Caffeine 5mg/kg, Codeine 2mg/kg) | Midazolam | 2020-07-08T0:0:0+0000 | BY NEH (Midazolam injection) | UKJ-19-020 | 9.566666666666666 | 28.5 | Yes | 9µl | Full | 00min | 1899-12-31T13:0:0+0000 | 0 | ||
9µl | Full | 05min | 1899-12-31T15:50:0+0000 | 0 | ||||||||||||||||
9µl | Full | 10min | 1899-12-31T15:55:0+0000 | 0 | ||||||||||||||||
9µl | Full | 15min | 1899-12-31T16:0:0+0000 | 0 | ||||||||||||||||
9µl | Full | 30min | 1899-12-31T16:15:0+0000 | 0 | ||||||||||||||||
9µl | Full | 01hr | 1899-12-31T16:45:0+0000 | 0 | ||||||||||||||||
9µl | Full | 02hr | 1899-12-31T17:45:0+0000 | 0 | ||||||||||||||||
9µl | Full | 04hr | 1899-12-31T19:45:0+0000 | 0 | ||||||||||||||||
9µl | Full | 24hr | 1900-01-01T15:45:0+0000 | 0 | ||||||||||||||||
1 | 2021-04-21T0:0:0+0000 | Mouse | Bl6 | MNT-011 | 1306 | Drug coktails (Midazolam 2mg/kg, Caffeine 5mg/kg, Codeine 2mg/kg) | Caffeine | 2020-07-08T0:0:0+0000 | BY NEH (Midazolam injection) | UKJ-19-020 | 9.566666666666666 | 28.5 | Yes | 9µl | Full | 00min | 1899-12-31T13:0:0+0000 | 0 | ||
9µl-0,5µl | Full except 0,5mm | 05min | 1899-12-31T15:50:0+0000 | 0 | ||||||||||||||||
9µl | Full | 10min | 1899-12-31T15:55:0+0000 | 0 | ||||||||||||||||
9µl | Full | 15min | 1899-12-31T16:0:0+0000 | 0 | ||||||||||||||||
9µl | Full | 30min | 1899-12-31T16:15:0+0000 | 0 | ||||||||||||||||
9µl | Full | 01hr | 1899-12-31T16:45:0+0000 | 0 | ||||||||||||||||
9µl | Full | 02hr | 1899-12-31T17:45:0+0000 | 0 | ||||||||||||||||
9µl | Full | 04hr | 1899-12-31T19:45:0+0000 | 0 | ||||||||||||||||
9µl | Full | 24hr | 1900-01-01T15:45:0+0000 | 0 | ||||||||||||||||
1 | 2021-04-21T0:0:0+0000 | Mouse | Bl6 | MNT-011 | 1306 | Drug coktails (Midazolam 2mg/kg, Caffeine 5mg/kg, Codeine 2mg/kg) | Codeine | 2020-07-08T0:0:0+0000 | BY NEH (Midazolam injection) | UKJ-19-020 | 9.566666666666666 | 28.5 | Yes | 9µl | Full | 00min | 1899-12-31T13:0:0+0000 | 0 | ||
9µl | Full | 05min | 1899-12-31T15:50:0+0000 | 0 | ||||||||||||||||
9µl | Full | 10min | 1899-12-31T15:55:0+0000 | 0 | ||||||||||||||||
9µl | Full | 15min | 1899-12-31T16:0:0+0000 | 0 | ||||||||||||||||
9µl | Full | 30min | 1899-12-31T16:15:0+0000 | 0 | ||||||||||||||||
9µl | Full | 01hr | 1899-12-31T16:45:0+0000 | 0 | ||||||||||||||||
9µl | Full | 02hr | 1899-12-31T17:45:0+0000 | 0 | ||||||||||||||||
9µl | Full | 04hr | 1899-12-31T19:45:0+0000 | 0 | ||||||||||||||||
9µl | Full | 24hr | 1900-01-01T15:45:0+0000 | 0 | ||||||||||||||||
1 | 2021-04-21T0:0:0+0000 | Mouse | Bl6 | MNT-014 | 1309 | Drug coktails (Midazolam 2mg/kg, Caffeine 5mg/kg, Codeine 2mg/kg) | Midazolam | 2020-07-08T0:0:0+0000 | BY NEH (Drug coktails (Midazolam 2mg/kg, Caffeine 5mg/kg, Codeine 2mg/kg) injection) | UKJ-19-020 | 9.566666666666666 | 28.5 | Yes | 9µl-2mm | Fulle except 2mm | 00min | 1899-12-31T13:0:0+0000 | 0 | ||
9µl | Full | 05min | 1899-12-31T15:50:0+0000 | 0 | ||||||||||||||||
9µl | Full | 10min | 1899-12-31T15:55:0+0000 | 0 | ||||||||||||||||
9µl | Full | 15min | 1899-12-31T16:0:0+0000 | 0 | ||||||||||||||||
9µl | Full | 30min | 1899-12-31T16:15:0+0000 | 0 | ||||||||||||||||
9µl | Full | 01hr | 1899-12-31T16:45:0+0000 | 0 | ||||||||||||||||
9µl | Full | 02hr | 1899-12-31T17:45:0+0000 | 0 | ||||||||||||||||
9µl | Full | 04hr | 1899-12-31T19:45:0+0000 | 0 | ||||||||||||||||
9µl | Full | 24hr | 1900-01-01T15:45:0+0000 | 0 | ||||||||||||||||
1 | 2021-04-21T0:0:0+0000 | Mouse | Bl6 | MNT-014 | 1309 | Drug coktails (Midazolam 2mg/kg, Caffeine 5mg/kg, Codeine 2mg/kg) | Caffeine | 2020-07-08T0:0:0+0000 | BY NEH (Drug coktails (Midazolam 2mg/kg, Caffeine 5mg/kg, Codeine 2mg/kg) injection) | UKJ-19-020 | 9.566666666666666 | 28.5 | Yes | 9µl | Full | 00min | 1899-12-31T13:0:0+0000 | 0 | ||
9µl | Full | 05min | 1899-12-31T15:50:0+0000 | 0 | ||||||||||||||||
9µl-2mm | Full except 2mm | 10min | 1899-12-31T15:55:0+0000 | 0 | ||||||||||||||||
9µl | Full | 15min | 1899-12-31T16:0:0+0000 | 0 | ||||||||||||||||
9µl | Full | 30min | 1899-12-31T16:15:0+0000 | 0 | ||||||||||||||||
9µl | Full _low Hematocrit | 01hr | 1899-12-31T16:45:0+0000 | 0 | ||||||||||||||||
9µl | Full | 02hr | 1899-12-31T17:45:0+0000 | 0 | ||||||||||||||||
9µl | Full | 04hr | 1899-12-31T19:45:0+0000 | 0 | ||||||||||||||||
9µl | Full | 24hr | 1900-01-01T15:45:0+0000 | 0 | ||||||||||||||||
1 | 2021-04-21T0:0:0+0000 | Mouse | Bl6 | MNT-014 | 1309 | Drug coktails (Midazolam 2mg/kg, Caffeine 5mg/kg, Codeine 2mg/kg) | Codeine | 2020-07-08T0:0:0+0000 | BY NEH (Drug coktails (Midazolam 2mg/kg, Caffeine 5mg/kg, Codeine 2mg/kg) injection) | UKJ-19-020 | 9.566666666666666 | 28.5 | Yes | 9µl | Full | 00min | 1899-12-31T13:0:0+0000 | 0 | ||
9µl | Full | 05min | 1899-12-31T15:50:0+0000 | 0 | ||||||||||||||||
9µl | Full | 10min | 1899-12-31T15:55:0+0000 | 0 | ||||||||||||||||
9µl | Full | 15min | 1899-12-31T16:0:0+0000 | 0 | ||||||||||||||||
9µl | Full | 30min | 1899-12-31T16:15:0+0000 | 0 | ||||||||||||||||
9µl | Full | 01hr | 1899-12-31T16:45:0+0000 | 0 | ||||||||||||||||
9µl | Full | 02hr | 1899-12-31T17:45:0+0000 | 0 | ||||||||||||||||
9µl | Full | 04hr | 1899-12-31T19:45:0+0000 | 0 | ||||||||||||||||
9µl | Full | 24hr | 1900-01-01T15:45:0+0000 | 0 | ||||||||||||||||
Run | Date | Species | µ | Animal ID | Entry no | Treatmnt | Tube | Date of birth-year (w) | used before | Protocol number | Age (month) | Weight (gr) | Restrainer | blood volume (µl) | comments_Filling level/Problems | Time point | Day time of sampling | Scoring result after last blood sample | ||
2 | 2021-04-26T0:0:0+0000 | Mouse | Bl6 | MNT-047 | 1338 | Control+Drug coktails (Midazolam 2mg/kg, Caffeine 5mg/kg, Codeine 2mg/kg) | Midazolam | 2020-08-31T0:0:0+0000 | UKJ-19-020 | 7.966666666666667 | 31.77 | Yes | 2samples (9µl-3mm&9-4mm) | Fulle except 3mm | 00min (2samples) | 1899-12-31T7:0:0+0000 | 0 | |||
9µl | Full | 05min | 1899-12-31T8:40:0+0000 | 0 | ||||||||||||||||
9µl | Full | 10min | 1899-12-31T8:45:0+0000 | 0 | ||||||||||||||||
9µl-0,25mm | Full_Very small gas bubble (0,25mm) | 15min | 1899-12-31T8:50:0+0000 | 0 | ||||||||||||||||
9µl | Full | 30min | 1899-12-31T9:5:0+0000 | 0 | ||||||||||||||||
9µl | Full | 01hr | 1899-12-31T9:35:0+0000 | 0 | ||||||||||||||||
9µl | Full | 02hr | 1899-12-31T10:35:0+0000 | 0 | ||||||||||||||||
9µl | Full | 04hr | 1899-12-31T12:35:0+0000 | 0 | ||||||||||||||||
9µl | Full | 12hr | 1899-12-31T20:35:0+0000 | 0 | ||||||||||||||||
9µl | Full | 24hr | 1899-12-31T8:35:0+0000 | 0 | ||||||||||||||||
2 | 2021-04-26T0:0:0+0000 | Mouse | Bl6 | MNT-047 | 1338 | Control+Drug coktails (Midazolam 2mg/kg, Caffeine 5mg/kg, Codeine 2mg/kg) | Caffeine | 2020-08-31T0:0:0+0000 | UKJ-19-020 | 7.966666666666667 | 31.77 | Yes | 9µl | Full | 00min | 1899-12-31T7:0:0+0000 | 0 | |||
9µl | Full | 05min | 1899-12-31T8:40:0+0000 | 0 | ||||||||||||||||
9µl | Full | 10min | 1899-12-31T8:45:0+0000 | 0 | ||||||||||||||||
9µl | Full | 15min | 1899-12-31T8:50:0+0000 | 0 | ||||||||||||||||
9µl | Full | 30min | 1899-12-31T9:5:0+0000 | 0 | ||||||||||||||||
9µl | Full | 01hr | 1899-12-31T9:35:0+0000 | 0 | ||||||||||||||||
9µl | Full | 02hr | 1899-12-31T10:35:0+0000 | 0 | ||||||||||||||||
9µl | Full | 04hr | 1899-12-31T12:35:0+0000 | 0 | ||||||||||||||||
9µl | Full | 12hr | 1899-12-31T20:35:0+0000 | 0 | ||||||||||||||||
9µl | Full | 24hr | 1899-12-31T8:35:0+0000 | 0 | ||||||||||||||||
2 | 2021-04-26T0:0:0+0000 | Mouse | Bl6 | MNT-047 | 1338 | Control+Drug coktails (Midazolam 2mg/kg, Caffeine 5mg/kg, Codeine 2mg/kg) | Codeine | 2020-08-31T0:0:0+0000 | UKJ-19-020 | 7.966666666666667 | 31.77 | Yes | 9µl | Full | 00min | 1899-12-31T7:0:0+0000 | 0 | |||
9µl | Full | 05min | 1899-12-31T8:40:0+0000 | 0 | ||||||||||||||||
9µl | Full | 10min | 1899-12-31T8:45:0+0000 | 0 | ||||||||||||||||
9µl | Full | 15min | 1899-12-31T8:50:0+0000 | 0 | ||||||||||||||||
9µl | Full | 30min | 1899-12-31T9:5:0+0000 | 0 | ||||||||||||||||
9µl | Full | 01hr | 1899-12-31T9:35:0+0000 | 0 | ||||||||||||||||
9µl | Full | 02hr | 1899-12-31T10:35:0+0000 | 0 | ||||||||||||||||
9µl | Full | 04hr | 1899-12-31T12:35:0+0000 | 0 | ||||||||||||||||
9µl | Full | 12hr | 1899-12-31T20:35:0+0000 | 0 | ||||||||||||||||
9µl | Full | 24hr | 1899-12-31T8:35:0+0000 | 0 | ||||||||||||||||
Run | Date | Species | µ | Animal ID | Entry no | Treatmnt | Tube | Date of birth-year (w) | used before | Protocol number | Age (month) | Weight (gr) | Restrainer | blood volume (µl) | comments_Filling level/Problems | Time point | Day time of sampling | Scoring result after last blood sample | ||
2 | 2021-04-26T0:0:0+0000 | Mouse | Bl6 | MNT-048 | 1339 | Control+Drug coktails (Midazolam 2mg/kg, Caffeine 5mg/kg, Codeine 2mg/kg) | Midazolam | 2020-08-31T0:0:0+0000 | UKJ-19-020 | 7.966666666666667 | 31.71 | Yes | 9µl | Full | 00min (2samples) | 1899-12-31T7:0:0+0000 | 0 | |||
9µl | Full | 05min | 1899-12-31T8:40:0+0000 | 0 | ||||||||||||||||
9µl | Full | 10min | 1899-12-31T8:45:0+0000 | 0 | ||||||||||||||||
9µl | Full | 15min | 1899-12-31T8:50:0+0000 | 0 | ||||||||||||||||
9µl | Full | 30min | 1899-12-31T9:5:0+0000 | 0 | ||||||||||||||||
9µl | Full | 01hr | 1899-12-31T9:35:0+0000 | 0 | ||||||||||||||||
9µl | Full | 02hr | 1899-12-31T10:35:0+0000 | 0 | ||||||||||||||||
9µl | Full | 04hr | 1899-12-31T12:35:0+0000 | 0 | ||||||||||||||||
9µl | Full | 12hr | 1899-12-31T20:35:0+0000 | 0 |
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Serial Nr | Animal EXP. ID | Entry-number | Ear pinch | Srain | Date of birth | Treatment | Comment to animal | Drugs | Animal weight at the day of drug injection (gm) | Animal weight at day of sacrifice (gm) | Day of drug cocktails injection | Other treatment | Day of sacrifice | Age months | Operation |
1 | MNT-047 | 1338 | Ohne | C57BL/6J | 2020-08-31T0:0:0+0000 | Normal food | n | cocktail consisting of (Midazolam 2mg/kg, Caffeine 5mg/kg, Codeine 2mg/kg | 30.71 | 28.5 | 2021-04-26T0:0:0+0000 | 0,0048 Buprenovet | 2021-04-27T0:0:0+0000 | 7.966666666666667 | Sacrifice |
2 | MNT-048 | 1339 | 1Li | C57BL/6J | 2020-08-31T0:0:0+0000 | Normal food | n | cocktail consisting of (Midazolam 2mg/kg, Caffeine 5mg/kg, Codeine 2mg/kg | 30.77 | 29.5 | 2021-04-26T0:0:0+0000 | 0,005 Buprenovet | 2021-04-27T0:0:0+0000 | 7.966666666666667 | Sacrifice |
3 | MNT-049 | 1340 | Ohne | C57BL/6J | 2020-08-31T0:0:0+0000 | Normal food | n | cocktail consisting of (Midazolam 2mg/kg, Caffeine 5mg/kg, Codeine 2mg/kg | 26.75 | 25 | 2021-04-30T0:0:0+0000 | 0,004 Buprenovet | 2021-05-01T0:0:0+0000 | 8.1 | Sacrifice |
4 | MNT-050 | 1341 | 1Li | C57BL/6J | 2020-08-31T0:0:0+0000 | Normal food | n | cocktail consisting of (Midazolam 2mg/kg, Caffeine 5mg/kg, Codeine 2mg/kg | 30.32 | 28 | 2021-04-30T0:0:0+0000 | 0,0046 Buprenovet | 2021-05-01T0:0:0+0000 | 8.1 | Sacrifice |
5 | MNT-051 | 1342 | Ohne | C57BL/6J | 2020-08-31T0:0:0+0000 | Normal food | n | cocktail consisting of (Midazolam 2mg/kg, Caffeine 5mg/kg, Codeine 2mg/kg | 29.8 | 29 | 2021-05-26T0:0:0+0000 | 0,0048 Buprenovet | 2021-05-27T0:0:0+0000 | 8.966666666666667 | Sacrifice |
6 | MNT-052 | 1343 | 1Li | C57BL/6J | 2020-08-31T0:0:0+0000 | Normal food | n | cocktail consisting of (Midazolam 2mg/kg, Caffeine 5mg/kg, Codeine 2mg/kg | 32.18 | 31 | 2021-05-26T0:0:0+0000 | 0,0054 Buprenovet | 2021-05-27T0:0:0+0000 | 8.966666666666667 | Sacrifice |
7 | MNT-053 | 1344 | Ohne | C57BL/6J | 2020-08-31T0:0:0+0000 | 2Wks MCD+HFD | n | cocktail consisting of (Midazolam 2mg/kg, Caffeine 5mg/kg, Codeine 2mg/kg | 31.41 | 31 | 2021-05-03T0:0:0+0000 | 0,005 Buprenovet | 2021-05-04T0:0:0+0000 | 8.2 | Sacrifice |
8 | MNT-054 | 1345 | 1Li | C57BL/6J | 2020-08-31T0:0:0+0000 | 2Wks MCD+HFD | n | cocktail consisting of (Midazolam 2mg/kg, Caffeine 5mg/kg, Codeine 2mg/kg | 31.38 | 31 | 2021-05-03T0:0:0+0000 | 0,005 Buprenovet | 2021-05-04T0:0:0+0000 | 8.2 | Sacrifice |
9 | MNT-055 | 1346 | 1Li | C57BL/6J | 2020-08-31T0:0:0+0000 | 2Wks MCD+HFD | n | cocktail consisting of (Midazolam 2mg/kg, Caffeine 5mg/kg, Codeine 2mg/kg | 30.41 | 30 | 2021-06-05T0:0:0+0000 | 0,005 Buprenovet | 2021-05-06T0:0:0+0000 | 8.266666666666667 | Sacrifice |
10 | MNT-056 | 1347 | Ohne | C57BL/6J | 2020-08-31T0:0:0+0000 | 2Wks MCD+HFD | n | cocktail consisting of (Midazolam 2mg/kg, Caffeine 5mg/kg, Codeine 2mg/kg | 29.2 | 28 | 2021-06-05T0:0:0+0000 | 0,0046 Buprenovet | 2021-05-06T0:0:0+0000 | 8.266666666666667 | Sacrifice |
11 | MNT-057 | 1348 | Ohne | C57BL/6J | 2020-08-31T0:0:0+0000 | 2Wks MCD+HFD | n | cocktail consisting of (Midazolam 2mg/kg, Caffeine 5mg/kg, Codeine 2mg/kg | 34.46 | 34 | 2021-05-07T0:0:0+0000 | 0,0048 Buprenovet | 2021-05-08T0:0:0+0000 | 8.333333333333334 | Sacrifice |
12 | MNT-058 | 1349 | 1li | C57BL/6J | 2020-08-31T0:0:0+0000 | 2Wks MCD+HFD | Animal had skin problems, injuries | cocktail consisting of (Midazolam 2mg/kg, Caffeine 5mg/kg, Codeine 2mg/kg | 29.19 | 29 | 2021-05-07T0:0:0+0000 | 0,006 Buprenovet | 2021-05-08T0:0:0+0000 | 8.333333333333334 | Sacrifice |
13 | MNT-059 | 1350 | Ohne | C57BL/6J | 2020-08-31T0:0:0+0000 | 4Wks MCD+HFD | n | cocktail consisting of (Midazolam 2mg/kg, Caffeine 5mg/kg, Codeine 2mg/kg | 32.3 | 32 | 2021-05-17T0:0:0+0000 | 0,0054 Buprenovet | 2021-05-18T0:0:0+0000 | 8.666666666666666 | Sacrifice |
14 | MNT-060 | 1351 | 1Li | C57BL/6J | 2020-08-31T0:0:0+0000 | 4Wks MCD+HFD | n | cocktail consisting of (Midazolam 2mg/kg, Caffeine 5mg/kg, Codeine 2mg/kg | 32.75 | 32.5 | 2021-05-17T0:0:0+0000 | 0,0055 Buprenovet | 2021-05-18T0:0:0+0000 | 8.666666666666666 | Sacrifice |
15 | MNT-061 | 1352 | Ohne | C57BL/6J | 2020-08-31T0:0:0+0000 | 4Wks MCD+HFD | n | cocktail consisting of (Midazolam 2mg/kg, Caffeine 5mg/kg, Codeine 2mg/kg | 33.1 | 33 | 2021-05-19T0:0:0+0000 | 0,0056 Buprenovet | 2021-05-20T0:0:0+0000 | 8.733333333333333 | Sacrifice |
16 | MNT-062 | 1353 | 1Li | C57BL/6J | 2020-08-31T0:0:0+0000 | 4Wks MCD+HFD | n | cocktail consisting of (Midazolam 2mg/kg, Caffeine 5mg/kg, Codeine 2mg/kg | 34.7 | 32.5 | 2021-05-19T0:0:0+0000 | 0,0056 Buprenovet | 2021-05-20T0:0:0+0000 | 8.733333333333333 | Sacrifice |
17 | MNT-063 | 1354 | Ohne | C57BL/6J | 2020-08-31T0:0:0+0000 | 4Wks MCD+HFD | n | cocktail consisting of (Midazolam 2mg/kg, Caffeine 5mg/kg, Codeine 2mg/kg | 31.7 | 31 | 2021-05-21T0:0:0+0000 | 0,0052 Buprenovet | 2021-05-22T0:0:0+0000 | 8.8 | Sacrifice |
18 | MNT-064 | 1355 | 1Li | C57BL/6J | 2020-08-31T0:0:0+0000 | 4Wks MCD+HFD | n | cocktail consisting of (Midazolam 2mg/kg, Caffeine 5mg/kg, Codeine 2mg/kg | 39.4 | 38 | 2021-05-21T0:0:0+0000 | 0,0068 Buprenovet | 2021-05-22T0:0:0+0000 | 8.8 | Sacrifice |
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3hr | MNT-057_03hr_Caffeine | Full | 3.1 | 8.72 | 1.03 | 0.309 | |||||||||
4hr | MNT-057_04hr_Caffeine | Full | 3.2 | 9 | 1 | 0.095 | |||||||||
6hr | MNT-057_06hr_Caffeine | Full | 3 | 8.44 | 1.07 | <0.010 | |||||||||
Codeine (ng/ml) | Norcodeine (ng/ml) | Codeine-6-Glucuronide (ng/ml) | Morphine-3-Glucuronide (ng/ml) | Morphine (ng/ml) | |||||||||||
1348 | MNT-057 | 2Wks MCD high fat diet injected ip with drug cocktail consisting of (Midazolam 2mg/kg, Caffeine 5mg/kg, Codeine 2mg/kg | 0min | MNT-057_00min_Codeine | Full | 3.2 | 9 | 1.11 | <0.1 | <0.5 | <0.5 | <0.1 | <0.1 | ||
10min | MNT-057_10min_Codeine6 | Full | 3.2 | 9 | 1.11 | 276 | 33 | 13 | 124 | 7.2 | |||||
30min | MNT-057_30min_Codeine | Full | 3.2 | 9 | 1.11 | 183 | 30 | 34 | 250 | 5.8 | |||||
1hr | MNT-057_01hr_Codeine | Full | 3.2 | 9 | 1.11 | 129 | 25 | 32 | 212 | 3.8 | |||||
1.5hr | MNT-057_1.5hr_Codeine | Full | 3.1 | 8.72 | 1.15 | 64 | 15 | 19 | 138 | 1.6 | |||||
2hr | MNT-057_2hr_Codeine | Fulll except 0,5mm | 3.1 | 8.72 | 1.15 | 34 | 10 | 7.9 | 63 | 0.5 | |||||
2.5hr | MNT-057_2.5hr_Codeine | Full | 3.1 | 8.72 | 1.15 | 25 | 7 | 4.4 | 38 | 0.2 | |||||
3hr | MNT-057_03hr_Codeine | Full | 3.1 | 8.72 | 1.15 | 17 | 5.9 | 2.1 | 22 | <0.1 | |||||
4hr | MNT-057_04hr_Codeine | Full | 3.1 | 8.72 | 1.15 | 9.7 | 3.5 | 1.1 | 36 | 1 | |||||
6hr | MNT-057_06hr_Codeine | Full | 3.1 | 8.72 | 1.15 | 6.9 | 1.9 | <0.5 | 37 | 1.3 | |||||
Date | Animal entry number | Animal ID | Treatment | sampling time point | sample name in the shipment | filling level_After sampling_Jena Lba | filling level in cm | corresponding volume in µL | dilution factor | Mother drug concentration | Metabolite 1 | Metabolite 2 | Metabolite 3 | Metabolite 4 | |
2021-05-07T0:0:0+0000 | Midazolam (ng/ml) | 1-OH-Midazolam (ng/ml) | |||||||||||||
1349 | MNT-058 Animal had skin problems | 2Wks MCD high fat diet injected ip with drug cocktail consisting of (Midazolam 2mg/kg, Caffeine 5mg/kg, Codeine 2mg/kg | 0min | MNT-058_00min_Midazolam | Full except 3mm | 2.9 | 8.16 | 1.1 | <0.1 | <0.1 | |||||
10min | MNT-058_10min_Midazolam | Full | 3.2 | 9 | 1 | 27.3 | 13.5 | ||||||||
30min | MNT-058_30min_Midazolam | Full | 3.2 | 9 | 1 | 33.3 | 43.1 | ||||||||
1hr | MNT-058_01hr_Midazolam | Full | 3.2 | 9 | 1 | 49.6 | 140.2 | ||||||||
1.5hr | MNT-058_1.5hr_Midazolam | Full | 3.1 | 8.72 | 1.03 | 3.3 | 12.9 | ||||||||
2hr | MNT-058_02hr_Midazolam | Full | 3.2 | 9 | 1 | 1.9 | 9 | ||||||||
2.5hr | MNT-058_2.5r_Midazolam | Full | 3.2 | 9 | 1 | <0.1 | 3.5 | ||||||||
3hr | MNT-058_03hr_Midazolam | Full | 3.2 | 9 | 1 | <0.1 | 8.6 | ||||||||
4hr | MNT-058_04hr_Midazolam | Full | 3.2 | 9 | 1 | <0.1 | 46.1 | ||||||||
6hr | MNT-058_06hr_Midazolam | Full | 3.2 | 9 | 1 | <0.1 | 10.9 | ||||||||
Caffeine (µg/ml) | |||||||||||||||
1349 | MNT-058 | 2Wks MCD high fat diet injected ip with drug cocktail consisting of (Midazolam 2mg/kg, Caffeine 5mg/kg, Codeine 2mg/kg | 0min | MNT-058_00min_Caffeine | Full except 8mm | 2 | 5.63 | 1.6 | <0.010 | ||||||
10min | MNT-058_10min_Caffeine | Full | 3.1 | 8.72 | 1.03 | 0.39 | |||||||||
30min | MNT-058_30min_Caffeine | Full | 3.2 | 9 | 1 | 0.472 | |||||||||
1hr | MNT-058_01hr_Caffeine | Full | 3.1 | 8.72 | 1.03 | 0.514 | |||||||||
1.5hr | MNT-058_1.5hr_Caffeine | Full | 3 | 8.44 | 1.07 | 0.354 | |||||||||
2hr | MNT-058_02hr_Caffeine | Full | 3.1 | 8.72 | 1.03 | 0.6 | |||||||||
2.5hr | MNT-058_2.5hr_Caffeine | Full | 3.1 | 8.72 | 1.03 | 0.214 | |||||||||
3hr | MNT-058_03hr_Caffeine | Full | 3.2 | 9 | 1 | 0.098 | |||||||||
4hr | MNT-058_04hr_Caffeine | Full | 3.2 | 9 | 1 | 0.098 | |||||||||
6hr | MNT-058_06hr_Caffeine | Full | 3.2 | 9 | 1 | <0.010 | |||||||||
Codeine (ng/ml) | Norcodeine (ng/ml) | Codeine-6-Glucuronide (ng/ml) | Morphine-3-Glucuronide (ng/ml) | Morphine (ng/ml) | |||||||||||
1349 | MNT-058 | 2Wks MCD high fat diet injected ip with drug cocktail consisting of (Midazolam 2mg/kg, Caffeine 5mg/kg, Codeine 2mg/kg | 0min | MNT-058_00min_Codeine | Full | 1.7 | 4.78 | 2.09 | <0.1 | <0.5 | <0.5 | <0.1 | <0.1 | ||
10min | MNT-058_10min_Codeine6 | Full | 3.1 | 8.72 | 1.15 | 224 | 26 | 3.4 | 113 | 11 | |||||
30min | MNT-058_30min_Codeine | Full | 3 | 8.44 | 1.18 | 176 | 32 | 9.3 | 228 | 8.2 | |||||
1hr | MNT-058_01hr_Codeine | Full | 3.1 | 8.72 | 1.15 | 63 | 21 | 7.7 | 208 | 3.5 | |||||
1.5hr | MNT-058_1.5hr_Codeine | Full | 3 | 8.44 | 1.18 | 41 | 9.8 | 3.7 | 100 | 1.8 | |||||
2hr | MNT-058_2hr_Codeine | Full | 3.2 | 9 | 1.11 | 22 | 6.8 | 1.5 | 48 | 0.5 | |||||
2.5hr | MNT-058_2.5hr_Codeine | Full | 3.2 | 9 | 1.11 | 18 | 5.8 | 0.9 | 34 | 0.4 | |||||
3hr | MNT-058_03hr_Codeine | Full | 3.2 | 9 | 1.11 | 15 | 4 | 0.9 | 32 | 0.7 | |||||
4hr | MNT-058_04hr_Codeine | Full | 3.1 | 8.72 | 1.15 | 11 | 2.8 | <0.5 | 50 | 1.3 | |||||
6hr | MNT-058_06hr_Codeine | Full | 3 | 8.44 | 1.18 | 5.2 | <0.5 | <0.5 | 56 | 1.5 | |||||
Date | Animal entry number | Animal ID | Treatment | sampling time point | sample name in the shipment | filling level_After sampling_Jena Lba | filling level in cm | corresponding volume in µL | dilution factor | Mother drug concentration | Metabolite 1 | Metabolite 2 | Metabolite 3 | Metabolite 4 | |
2021-05-17T0:0:0+0000 | Midazolam (ng/ml) | 1-OH-Midazolam (ng/ml) | |||||||||||||
1350 | MNT-059 | 4Wks MCD high fat diet injected ip with drug cocktail consisting of (Midazolam 2mg/kg, Caffeine 5mg/kg, Codeine 2mg/kg | 0min | MNT-059_00min_Midazolam | Full | 3.2 | 9 | 1 | <0.1 | <0.1 | |||||
10min | MNT-059_10min_Midazolam | Full | 3.2 | 9 | 1 | 27 | 23.5 | ||||||||
30min | MNT-059_30min_Midazolam | Full | 3.2 | 9 | 1 | 158.9 | 285.5 | ||||||||
1hr | MNT-059_01hr_Midazolam | Full | 3.2 | 9 | 1 | 20.3 | 55.8 | ||||||||
1.5hr | MNT-059_1.5hr_Midazolam | Full | 3.2 | 9 | 1 | 8.2 | 24.8 | ||||||||
2hr | MNT-059_02hr_Midazolam | Full | 3.2 | 9 | 1 | 3 | 8.5 | ||||||||
2.5hr | MNT-059_2.5r_Midazolam | Full | 3.2 | 9 | 1 | 2.6 | 13.2 | ||||||||
3hr | MNT-059_03hr_Midazolam | Full | 3.2 | 9 | 1 | <0.1 | 7.6 | ||||||||
4hr | MNT-059_04hr_Midazolam | Full | 3.2 | 9 | 1 | <0.1 | 7 | ||||||||
6hr | MNT-059_06hr_Midazolam | Full | 3.2 | 9 | 1 | <0.1 | 34.8 | ||||||||
Caffeine (µg/ml) | |||||||||||||||
1350 | MNT-059 | 4Wks MCD high fat diet injected ip with drug cocktail consisting of (Midazolam 2mg/kg, Caffeine 5mg/kg, Codeine 2mg/kg | 0min | MNT-059_00min_Caffeine | Full | 3 | 8.44 | 1.07 | <0.010 | ||||||
10min | MNT-059_10min_Caffeine | Full | 3.2 | 9 | 1 | 1.33 | |||||||||
30min | MNT-059_30min_Caffeine | Full | 3.1 | 8.72 | 1.03 | 1.108 | |||||||||
1hr | MNT-059_01hr_Caffeine | Full | 3.1 | 8.72 | 1.03 | 0.673 | |||||||||
1.5hr | MNT-059_1.5hr_Caffeine | Full | 3.1 | 8.72 | 1.03 | 1.164 | |||||||||
2hr | MNT-059_02hr_Caffeine | Full | 3.1 | 8.72 | 1.03 | 0.883 | |||||||||
2.5hr | MNT-059_2.5hr_Caffeine | Full | 3.1 | 8.72 | 1.03 | 0.311 | |||||||||
3hr | MNT-059_03hr_Caffeine | Full | 3.1 | 8.72 | 1.03 | 0.316 | |||||||||
4hr | MNT-059_04hr_Caffeine | Full except 0,3mm | 2.8 | 7.88 | 1.14 | 0.227 | |||||||||
6hr | MNT-059_06hr_Caffeine | Full except 01mm | 3 | 8.44 | 1.07 | <0.010 | |||||||||
Codeine (ng/ml) | Norcodeine (ng/ml) | Codeine-6-Glucuronide (ng/ml) | Morphine-3-Glucuronide (ng/ml) | Morphine (ng/ml) | |||||||||||
1350 | MNT-059 | 4Wks MCD high fat diet injected ip with drug cocktail consisting of (Midazolam 2mg/kg, Caffeine 5mg/kg, Codeine 2mg/kg | 0min | MNT-059_00min_Codeine | Full | 3.2 | 9 | 1.11 | <0.1 | <0.5 | <0.5 | <0.1 | <0.1 | ||
10min | MNT-059_10min_Codeine6 | Full | 3.1 | 8.72 | 1.15 | 249 | 43 | 32 | 226 | 6.1 | |||||
30min | MNT-059_30min_Codeine | Full | 3.1 | 8.72 | 1.15 | 192 | 34 | 47 | 336 | 4.5 | |||||
1hr | MNT-059_01hr_Codeine | Full | 3.1 | 8.72 | 1.15 | 97 | 26 | 30 | 214 | 3.6 | |||||
1.5hr | MNT-059_1.5hr_Codeine | Full | 3.1 | 8.72 | 1.15 | 54 | 16 | 15 | 118 | 1.1 | |||||
2hr | MNT-059_2hr_Codeine | Full | 3.2 | 9 | 1.11 | 31 | 9.6 | 8 | 73 | 1.2 | |||||
2.5hr | MNT-059_2.5hr_Codeine | Full | 3.2 | 9 | 1.11 | 21 | 5.1 | 3.5 | 48 | 1 | |||||
3hr | MNT-059_03hr_Codeine | Full | 3.1 | 8.72 | 1.15 | 19 | 5 | 3.5 | 56 | 1.3 | |||||
4hr | MNT-059_04hr_Codeine | Full except 0,5mm | 3.1 | 8.72 | 1.15 | 9.8 | 2.2 | 0.9 | 25 | 0.4 | |||||
6hr | MNT-059_06hr_Codeine | Full | 3.1 | 8.72 | 1.15 | 5.6 | 1.2 | <0.5 | 26 | 0.6 | |||||
Date | Animal entry number | Animal ID | Treatment | sampling time point | sample name in the shipment | filling level_After sampling_Jena Lba | filling level in cm | corresponding volume in µL | dilution factor | Mother drug concentration | Metabolite 1 | Metabolite 2 | Metabolite 3 | Metabolite 4 | |
2021-05-17T0:0:0+0000 | Midazolam (ng/ml) | 1-OH-Midazolam (ng/ml) | |||||||||||||
1351 | MNT-060 | 4Wks MCD high fat diet injected ip with drug cocktail consisting of (Midazolam 2mg/kg, Caffeine 5mg/kg, Codeine 2mg/kg | 0min | MNT-060_00min_Midazolam | Full | 3.2 | 9 | 1 | <0.1 | <0.1 | |||||
10min | MNT-060_10min_Midazolam | Full | 3.2 | 9 | 1 | 20 | 16.7 | ||||||||
30min | MNT-060_30min_Midazolam | Full | 3.2 | 9 | 1 | 25.2 | 39.3 | ||||||||
1hr | MNT-060_01hr_Midazolam | Full | 3.2 | 9 | 1 | 11 | 24 | ||||||||
1.5hr | MNT-060_1.5hr_Midazolam | Full | 3.2 | 9 | 1 | 61.1 | 176.5 | ||||||||
2hr | MNT-060_02hr_Midazolam | Full | 3.2 | 9 | 1 | 8.3 | 23.8 | ||||||||
2.5hr | MNT-060_2.5r_Midazolam | Full | 3.2 | 9 | 1 | 5.2 | 13.3 | ||||||||
3hr | MNT-060_03hr_Midazolam | Full | 3.2 | 9 | 1 | 5.5 | 15.9 | ||||||||
4hr | MNT-060_04hr_Midazolam | Full | 3.2 | 9 | 1 | 11.3 | 29.6 | ||||||||
6hr | MNT-060_06hr_Midazolam | Full | 3.2 | 9 | 1 | <0.1 | 5.5 | ||||||||
Caffeine (µg/ml) | |||||||||||||||
1351 | MNT-060 | 4Wks MCD high fat diet injected ip with drug cocktail consisting of (Midazolam 2mg/kg, Caffeine 5mg/kg, Codeine 2mg/kg | 0min | MNT-060_00min_Caffeine | Full except 05mm | 2 | 5.63 | 1.6 | <0.010 | ||||||
10min | MNT-060_10min_Caffeine | Full | 3.1 | 8.72 | 1.03 | 1.11 |