Model | Supplementary table

Selected Cell

Cell:

Value:

Reactions Loci Enzymes Metabolites Metabolite-Reactions

101

102

103

104

105

106

107

108

109

110

111

112

113

114

115

116

117

118

119

120

121

122

123

124

125

126

127

128

129

130

131

132

133

134

135

136

137

138

139

140

141

142

143

144

145

146

147

148

149

150

151

152

153

154

155

156

157

158

159

160

161

162

163

164

165

166

167

168

169

170

171

172

173

174

175

176

177

178

179

180

181

182

183

184

185

186

187

188

189

190

191

192

193

194

195

196

197

198

199

200

100	Transporter	sym- and antiporter		_trans_pyruvate_2.A.56.3.4_trans-H+	1 pyruvate + 2 H+ <-- 2 H+_ex + 1 pyruvate_ex	EbN1_C05540, EbN1_C05560, EbN1_C05550
101	Transporter	sym- and antiporter		_trans_aromatics_toluene_trans-H+	1 toluene + 2 H+ <-- 1 H+_ex + 1 toluene_ex	EbN1_C10760
102	Transporter	sym- and antiporter		_trans_mannose_trans-PTS	1 alpha-D-mannose_6-phosphate + 1 pyruvate <-- 1 phosphoenolpyruvate + 1 D-mannose_ex	EbN1_C15830
103	Transporter	sym- and antiporter		_trans_fructose_trans-PTS	1 D-fructose_6-phosphate + 1 pyruvate <-- 1 phosphoenolpyruvate + 1 D-fructose_ex	EbN1_C15830
104	Transporter	sym- and antiporter		_trans_O-antigen_3.A.1.103.6_7.-.2.-_trans-ABC	1 O-antigen + 1 ATP + 1 H2O --> 1 O-antigen_ex + 1 H+ + 1 ADP + 1 phosphate	EbN1_C08820	7.-.2.-
105	Transporter	sym- and antiporter		_trans_arsenate_3.A.4.1.1_7.3.2.7_trans-ABC	1 arsenate + 1 ATP + 1 H2O --> 1 arsenate_ex + 1 H+ + 1 ADP + 1 phosphate	EbN1_C28700	7.3.2.7
106	Transporter	sym- and antiporter		_trans_Fe3+_3.A.1.10.4_7.2.2.7_trans-ABC	1 Fe3+ + 1 H+ + 1 ADP + 1 phosphate <-- 1 ATP + 1 H2O + 1 Fe3+_ex	EbN1_C28090, EbN1_C11820	7.2.2.7
107	Transporter	sym- and antiporter		_trans_Cu+_3.A.3.5.39_7.2.2.8_trans-ABC	1 Cu+ + 1 H+ + 1 ATP + 1 H2O --> 1 ADP + 1 Cu+_ex + 1 phosphate	EbN1_C12170, EbN1_C29600, EbN1_C29410	7.2.2.8
108	Transporter	sym- and antiporter		_trans_Ca2+_3.A.3.2.41_7.2.2.10_trans-ABC	1 Ca2+ + 1 H+ + 1 ADP + 1 phosphate <-- 1 ATP + 1 H2O + 1 Ca2+_ex	EbN1_C23700	7.2.2.10
109	Transporter	sym- and antiporter		_trans_phosphate_3.A.1.7.1_7.3.2.1_trans-ABC	2 phosphate + 1 H+ + 1 ADP <-- 1 ATP + 1 H2O + 1 phosphate_ex	EbN1_C27620	7.3.2.1
110	Transporter	sym- and antiporter		_trans_sulfate_3.A.1.6.1_7.3.2.3_trans-ABC	1 sulfate + 1 phosphate + 1 H+ + 1 ADP <-- 1 ATP + 1 H2O + 1 sulfate_ex	EbN1_C35880	7.3.2.3
111	Transporter	sym- and antiporter		_trans_tungstate_3.A.1.6.2_7.3.2.6_trans-ABC	1 tungstate + 1 phosphate + 1 H+ + 1 ADP <-- 1 ATP + 1 H2O + 1 tungstate_ex	EbN1_C28800	7.3.2.6
112	Transporter	sym- and antiporter		_trans_heme_3.A.1.107.1_7.6.2.5_trans-ABC	1 heme + 1 ADP + 1 phosphate + 1 H+ <-- 1 heme_ex + 1 ATP + 1 H2O	EbN1_C19970	7.6.2.5
113	Transporter	sym- and antiporter		_trans_adenosylcobalamin_3.A.1.13.1_7.6.2.-_trans-ATP	1 adenosylcobalamin + 1 ADP + 1 phosphate + 1 H+ <-- 1 adenosylcobalamin_ex + 1 ATP + 1 H2O	EbN1_C23020, EbN1_C20990	7.6.2.-
114	Transporter	sym- and antiporter		_trans_molybdate_3.A.1.8.-_7.3.2.5_trans-ABC	1 molybdate + 1 phosphate + 1 H+ + 1 ADP <-- 1 ATP + 1 H2O + 1 molybdate_ex	EbN1_C15390	7.3.2.5
115	Transporter	sym- and antiporter		_trans_sn-glycerol-3-phosphate_trans-ABC	1 sn-glycerol-3-phosphate + 1 phosphate + 1 H+ + 1 ADP <-- 1 ATP + 1 H2O + 1 sn-glycerol-3-phosphate_ex	EbN1_C25810
116	Transporter	sym- and antiporter		_trans_L-glutamate_3.A.1.3.22_7.4.2.1_trans-ABC	1 L-glutamate + 1 phosphate + 1 H+ + 1 ADP <-- 1 ATP + 1 H2O + 1 L-glutamate_ex	EbN1_C26080	7.4.2.1
117	Transporter	sym- and antiporter		_trans_L-aspartate_3.A.1.3.22_7.4.2.1_trans-ABC	1 L-aspartate + 1 phosphate + 1 H+ + 1 ADP <-- 1 ATP + 1 H2O + 1 L-aspartate_ex	EbN1_C26080	7.4.2.1
118	Transporter	sym- and antiporter		_trans_glutathione_3.A.1.5.11_7.4.2.10_trans-ABC	1 glutathione + 1 phosphate + 1 H+ + 1 ADP <-- 1 ATP + 1 H2O + 1 glutathione_ex	EbN1_C37390, EbN1_C32530	7.4.2.10
119	Transporter	sym- and antiporter		_trans_aromatics_benzoate_3.A.1.4.15_trans-ABC	1 benzoate + 1 ADP + 1 phosphate + 1 H+ <-- 1 benzoate_ex + 1 ATP + 1 H2O	EbN1_C30460, EbN1_C30450, EbN1_C30470
120	Transporter	sym- and antiporter		_trans_aromatics_3-phenylpropanoate_ex_3.A.1.4.15_trans-ABC	1 3-phenylpropanoate_ex + 1 ADP + 1 phosphate + 1 H+ <-- 1 3-phenylpropanoate_ex_ex + 1 ATP + 1 H2O	EbN1_C30460, EbN1_C30450, EbN1_C30470
121	Transporter	sym- and antiporter		_trans_aromatics_3-(4-hydroxyphenyl)propanoate_3.A.1.4.15_trans-ABC	1 3-(4-hydroxyphenyl)propanoate + 1 ADP + 1 phosphate + 1 H+ <-- 1 3-(4-hydroxyphenyl)propanoate_ex + 1 ATP + 1 H2O	EbN1_C30460, EbN1_C30470
122	Transporter	sym- and antiporter		_trans_aromatics_phenylethylamine_3.A.1.106.2_trans-ABC	1 2-phenylethylamine + 1 ADP + 1 phosphate + 1 H+ <-- 1 2-phenylethylamine_ex + 1 ATP + 1 H2O	EbN1_C29750
123	Transporter	sym- and antiporter		_trans_aromatics_indoleacetate_3.A.1.4.15_trans-ABC	1 (indol-3-yl)acetate + 1 ADP + 1 phosphate + 1 H+ <-- 1 (indol-3-yl)acetate_ex + 1 ATP + 1 H2O	EbN1_C11610
124	Transporter	sym- and antiporter		_trans_aromatics_L-phenylalanine_trans-ATP	1 L-phenylalanine + 1 ADP + 1 phosphate + 1 H+ <-- 1 L-phenylalanine_ex + 1 ATP + 1 H2O	EbN1_C20250, EbN1_C20270		bA3558,
125	Transporter	sym- and antiporter		_trans_aromatics_phenylacetate_trans-ATP	1 phenylacetate + 1 ADP + 1 phosphate + 1 H+ <-- 1 phenylacetate_ex + 1 ATP + 1 H2O	EbN1_C20250, EbN1_C20260		ebA3557,
126	Transporter	sym- and antiporter		_trans_aromatics_cyclohexanecarboxylate_trans-H+	1 cyclohexanecarboxylate + 2 H+ <-- 2 H+_ex + 1 cyclohexanecarboxylate_ex	EbN1_C03820, EbN1_C03810
127	Transporter	sym- and antiporter		_trans_aromatics_benzaldehyde_trans-H+	1 benzaldehyde + 2 H+ <-- 1 benzaldehyde_ex + 2 H+_ex			in the medium
128	Transporter	sym- and antiporter		_trans_aromatics_p-cresol_trans-H+	1 4-cresol + 2 H+ <-- 1 H+_ex + 1 4-cresol_ex	EbN1_C03820, EbN1_C03810
129	Transporter	sym- and antiporter		_trans_aromatics_phenol_trans-H+	1 phenol + 2 H+ <-- 1 H+_ex + 1 phenol_ex	EbN1_C03820, EbN1_C03810
130	Transporter	sym- and antiporter		_trans_aromatics_ethylbenzene_trans-H+	1 ethylbenzene + 2 H+ <-- 1 H+_ex + 1 ethylbenzene_ex	EbN1_C03820, EbN1_C03810
131	Transporter	sym- and antiporter		_trans_folate_trans-H+	1 folate + 2 H+ --> 2 H+_ex + 1 folate_ex			in the medium
132	Transporter	sym- and antiporter		_trans_Co2+_efflux	1 Co2+ --> 1 Co2+_ex	EbN1_C37950
133	Transporter	sym- and antiporter		_trans_Mg2+_efflux	1 Mg2+ --> 1 Mg2+_ex	EbN1_C37950
134	Transporter	sym- and antiporter		_trans_alanine_2.A.25.1.2_trans	1 L-alanine + 2 H+ <-- 2 H+_ex + 1 L-alanine_ex	EbN1_C25910
135	Transporter	sym- and antiporter		_trans_aromatics_cinnamate_2.A.1.27.1_trans-H+	1 cinnamate + 2 H+ <-- 1 H+_ex + 1 cinnamate_ex			in the medium
136	Transporter	sym- and antiporter		_trans_aromatics_cinnamate_3.A.1.4.15_trans-ABC	1 cinnamate + 1 ADP + 1 phosphate + 1 H+ <-- 1 cinnamate_ex + 1 ATP + 1 H2O	EbN1_C11610
137	Transporter	sym- and antiporter		_trans_aromatics_hydrocinnamate_2.A.1.27.1_trans-H+	1 phenylpropionate + 2 H+ <-- 1 H+_ex + 1 phenylpropionate_ex			in the medium
138	Transporter	sym- and antiporter		_trans_aromatics_hydrocinnamate_3.A.1.4.15_trans-ABC	1 phenylpropionate + 1 ADP + 1 phosphate + 1 H+ <-- 1 phenylpropionate_ex + 1 ATP + 1 H2O	EbN1_C11610
139	Transporter	sym- and antiporter		_trans_aromatics_p-coumarate_2.A.1.27.1_trans-H+	1 p-coumarate + 2 H+ <-- 1 H+_ex + 1 p-coumarate_ex			in the medium
140	Transporter	sym- and antiporter		_trans_aromatics_p-coumarate_3.A.1.4.15_trans-ABC	1 p-coumarate + 1 ADP + 1 phosphate + 1 H+ <-- 1 p-coumarate_ex + 1 ATP + 1 H2O	EbN1_C11610
141	Transporter	sym- and antiporter		_trans_cation_M2+_2.A.4.1.3_trans	1 cation_M2+ + 2 H+_ex --> 2 H+ + 1 cation_M2+_ex	EbN1_C25910
142	Transporter	sym- and antiporter		_trans_cation_M2+_3.A.1.15.19_trans-ABC	1 cation_M2+ + 1 ADP + 1 phosphate + 1 H+ <-- 1 cation_M2+_ex + 1 ATP + 1 H2O	EbN1_C11610
143	Transporter	sym- and antiporter		_trans_Cl-_2.A.4.1.3_trans-H+	2 Cl- + 1 H+_ex <=> 2 Cl-_ex + 1 H+			in the medium
144	Transporter	sym- and antiporter		_trans_nitrate_2.A.1.8.2_trans	1 nitrate <=> nitrate_ex	EbN1_C06580
145	Transporter	sym- and antiporter		_trans_nitrite_2.A.1.8.17_trans-nitrate	1 nitrate + 1 nitrite_ex <-- 1 nitrite + 1 nitrate_ex	EbN1_C36370
146	Transporter	sym- and antiporter		_trans_potassium_2.A.37.1.3_trans	1 potassium + 2 H+_ex --> 2 H+ + 1 potassium_ex	EbN1_C25910
147	Transporter	sym- and antiporter		_trans_potassium_2.A.38.1.1_trans	1 potassium <--1 potassium_ex	EbN1_C15990
148	Transporter	sym- and antiporter		_trans_potassium_2.A.38.4.3_trans	1 potassium <-- 1 potassium_ex	EbN1_C31980, EbN1_C15530, EbN1_C15540
149	Transporter	sym- and antiporter		_trans_potassium_2.A.63.1.1_trans-H+	1 potassium + 2 H+_ex --> 2 H+ + 1 potassium_ex	EbN1_C02950, EbN1_C02940, EbN1_C02930
150	Transporter	sym- and antiporter		_trans_potassium_2.A.72.1.1_trans	1 potassium + 2 H+_ex --> 2 H+ + 1 potassium_ex	EbN1_C20660
151	Transporter	sym- and antiporter		_trans_sodium_2.A.36.-.-_trans	1 sodium + 2 H+_ex --> 2 H+ + 1 sodium_ex	EbN1_C25910
152	Central carbon metabolism	Glycolysis / gluconeogenesis	GLUCOKIN-RXN	glycolysis_2.7.1.2_GLUCOKIN-RXN	1 beta-D-glucose + 1 ATP --> 1 H+ + 1 beta-D-glucose_6-phosphate + 1 ADP	EbN1_C03120	2.7.1.2
153	Central carbon metabolism	Glycolysis / gluconeogenesis	PGLUCISOM-RXN	glycolysis_5.3.1.9_PGLUCISOM-RXN	1 beta-D-glucose_6-phosphate <=> 1 D-fructose_6-phosphate	EbN1_C29870	5.3.1.9
154	Central carbon metabolism	Glycolysis / gluconeogenesis	GLUCOSE-6-PHOSPHATE-1-EPIMERASE-RXN	glycolysis_5.3.1.9_GLUCOSE-6-PHOSPHATE-1-EPIMERASE-RXN	1 alpha-D-glucose_6-phosphate <=> 1 beta-D-glucose_6-phosphate	EbN1_C29870	5.3.1.9
155	Central carbon metabolism	Glycolysis / gluconeogenesis	RXN-6182	glycolysis_5.3.1.9_RXN-6182	1 alpha-D-glucose_6-phosphate <=> 1 D-fructose_6-phosphate	EbN1_C29870	5.3.1.9
156	Central carbon metabolism	Glycolysis / gluconeogenesis	PHOSPHOGLUCMUT-RXN	glycolysis_5.4.2.2_PHOSPHOGLUCMUT-RXN	1 alpha-D-glucose_1-phosphate <=> 1 alpha-D-glucose_6-phosphate	EbN1_C05390	5.4.2.2
157	Central carbon metabolism	Glycolysis / gluconeogenesis	2.7.1.90-RXN	glycolysis_2.7.1.90_2.7.1.90-RXN	1 D-fructose_6-phosphate + 1 diphosphate <=> 1 H+ + 1 phosphate + 1 D-fructose_1,6-bisphosphate	EbN1_C29130	2.7.1.90
158	Central carbon metabolism	Glycolysis / gluconeogenesis	F16ALDOLASE-RXN	glycolysis_4.1.2.13_F16ALDOLASE-RXN	1 D-fructose_1,6-bisphosphate <=> 1 D-glyceraldehyde_3-phosphate + 1 dihydroxyacetone_phosphate	EbN1_C05940	4.1.2.13
159	Central carbon metabolism	Glycolysis / gluconeogenesis	TRIOSEPISOMERIZATION-RXN	glycolysis_5.3.1.1_TRIOSEPISOMERIZATION-RXN	1 D-glyceraldehyde_3-phosphate <=> 1 dihydroxyacetone_phosphate	EbN1_C27630	5.3.1.1
160	Central carbon metabolism	Glycolysis / gluconeogenesis	GAPOXNPHOSPHN-RXN	glycolysis_1.2.1.12_GAPOXNPHOSPHN-RXN	1 NAD+ + 1 D-glyceraldehyde_3-phosphate + 1 phosphate <=> 1 1,3-bisphospho-D-glycerate + 1 H+ + 1 NADH	EbN1_C05910	1.2.1.12
161	Central carbon metabolism	Glycolysis / gluconeogenesis	PHOSGLYPHOS-RXN	glycolysis_2.7.2.3_PHOSGLYPHOS-RXN	1 ATP + 1 3-phospho-D-glycerate <=> 1 ADP + 1 1,3-bisphospho-D-glycerate	EbN1_C05920	2.7.2.3
162	Central carbon metabolism	Glycolysis / gluconeogenesis	3PGAREARR-RXN	glycolysis_5.4.2.11_3PGAREARR-RXN	1 2-phospho-D-glycerate <=> 1 3-phospho-D-glycerate	EbN1_C05660	5.4.2.11
163	Central carbon metabolism	Glycolysis / gluconeogenesis	2PGADEHYDRAT-RXN	glycolysis_4.2.1.11_2PGADEHYDRAT-RXN	1 2-phospho-D-glycerate <=> 1 phosphoenolpyruvate + 1 H2O	EbN1_C35610	4.2.1.11
164	Central carbon metabolism	Glycolysis / gluconeogenesis	PEPDEPHOS-RXN	glycolysis_2.7.1.40_PEPDEPHOS-RXN	1 H+ + 1 ADP + 1 phosphoenolpyruvate --> 1 ATP + 1 pyruvate	EbN1_C05930	2.7.1.40
165	Central carbon metabolism	Glycolysis / gluconeogenesis	PYRUVDEH-RXN	glycolysis_1.2.5.1_1.8.1.4_2.3.1.12_1.2.4.1_PYRUVDEH-RXN	1 CoA + 1 NAD+ + 1 pyruvate --> 1 acetyl-CoA + 1 CO2 + 1 NADH	EbN1_C00700	2.3.1.12, 1.2.4.1, 1.8.1.4, 1.2.5.1
166	Central carbon metabolism	Glycolysis / gluconeogenesis	F16BDEPHOS-RXN	gluconeogenesis_3.1.3.11_F16BDEPHOS-RXN	1 H2O + 1 D-fructose_1,6-bisphosphate --> 1 phosphate + 1 D-fructose_6-phosphate	EbN1_C06420	3.1.3.11
167	Central carbon metabolism	Glycolysis / gluconeogenesis	PEPSYNTH-RXN	gluconeogenesis_2.7.9.2_PEPSYNTH-RXN	1 ATP + 1 H2O + 1 pyruvate --> 1 AMP + 1 phosphoenolpyruvate + 1 phosphate + 2 H+	EbN1_C33510, EbN1_C17780, EbN1_C17790, EbN1_C17770	2.7.9.2
168	Central carbon metabolism	Glycolysis / gluconeogenesis	MALIC-NADP-RXN	gluconeogenesis_1.1.1.40_MALIC-NADP-RXN	1 (S)-malate + 1 NADP+ --> 1 CO2 + 1 pyruvate + 1 NADPH + 1 H+	EbN1_C25140, EbN1_C23160	1.1.1.40
169	Central carbon metabolism	Glycolysis / gluconeogenesis	4.1.1.32-RXN	gluconeogenesis_4.1.1.32_4.1.1.32-RXN	1 GTP + 1 oxaloacetate --> 1 GDP + 1 CO2 + 1 phosphoenolpyruvate	EbN1_C23140	4.1.1.32
170	Central carbon metabolism	TCA cycle	CITSYN-RXN	TCA-cycle_2.3.3.1_CITSYN-RXN	1 H2O + 1 oxaloacetate + 1 acetyl-CoA --> 1 CoA + 1 H+ + 1 citrate	EbN1_C38650	2.3.3.1
171	Central carbon metabolism	TCA cycle	RXN-14047	TCA-cycle_4.2.1.3_RXN-14047	1 citrate <=> 1 D-threo-isocitrate	EbN1_C30200, EbN1_C39170, EbN1_C30210	4.2.1.3
172	Central carbon metabolism	TCA cycle	ISOCITDEH-RXN	TCA-cycle_1.1.1.42_ISOCITDEH-RXN	1 NADP+ + 1 D-threo-isocitrate --> 1 NADPH + 1 CO2 + 1 2-oxoglutarate	EbN1_C04460, EbN1_C04450	1.1.1.42
173	Central carbon metabolism	TCA cycle	2-OXOGLUTARATE-SYNTHASE-RXN	TCA-cycle_1.2.7.3_2-OXOGLUTARATE-SYNTHASE-RXN	1 CoA + 2 oxidized_ferredoxin + 1 2-oxoglutarate --> 1 H+ + 1 CO2 + 1 succinyl-CoA + 2 reduced_ferredoxin	EbN1_C17820, EbN1_PII00050, EbN1_C26200, EbN1_PII00070, EbN1_C26220, EbN1_C17830, EbN1_PII00060, EbN1_C26210	1.2.7.3
174	Central carbon metabolism	TCA cycle	2-oxoglutarate-dehydrogenase-complex	TCA-cycle_1.2.4.2_1.8.1.4_2.3.1.61_1.2.1.105_2-oxoglutarate-dehydrogenase-complex	1 CoA + NAD+ + 1 2-oxoglutarate --> 1 H+ + 1 CO2 + 1 succinyl-CoA + 1 NADH		1.2.1.105, 2.3.1.61, 1.8.1.4, 1.2.4.2
175	Central carbon metabolism	TCA cycle	SUCCCOASYN-RXN	TCA-cycle_6.2.1.5_SUCCCOASYN-RXN	1 ADP + 1 phosphate + 1 succinyl-CoA <=> 1 succinate + 1 ATP + 1 CoA	EbN1_C06930, EbN1_C06920	6.2.1.5
176	Central carbon metabolism	TCA cycle	SUCCINATE-DEHYDROGENASE-UBIQUINONE-RXN	TCA-cycle_1.3.5.1_SUCCINATE-DEHYDROGENASE-UBIQUINONE-RXN	1 ubiquinone-8 + 1 succinate <=> 1 ubiquinol-8 + 1 fumarate	EbN1_C38690, EbN1_C26150, EbN1_C26140, EbN1_C38700, EbN1_C38670, EbN1_C38680, EbN1_C26130	1.3.5.1
177	Central carbon metabolism	TCA cycle	FUMHYDR-RXN	TCA-cycle_4.2.1.2_FUMHYDR-RXN	1 fumarate + 1 H2O <=> 1 (S)-malate	EbN1_C00970, EbN1_C21240	4.2.1.2
178	Central carbon metabolism	TCA cycle	MALATE-DEHYDROGENASE-NADP+-RXN	TCA-cycle_1.1.1.37_MALATE-DEHYDROGENASE-NADP+-RXN	1 (S)-malate + 1 NAD+ <=> 1 H+ + 1 NADH + 1 oxaloacetate	EbN1_C38730	1.1.1.37
179	Central carbon metabolism	Glyoxylate shunt, anaplerotic reactions, gluconeogenesis	ISOCIT-CLEAV-RXN	TCA-cycle_glyoxylate-shunt_4.1.3.1_ISOCIT-CLEAV-RXN	1 D-threo-isocitrate --> 1 succinate + 1 glyoxylate	EbN1_C25580	4.1.3.1
180	Central carbon metabolism	Glyoxylate shunt, anaplerotic reactions, gluconeogenesis	MALSYN-RXN	TCA-cycle_glyoxylate-shunt_2.3.3.9_MALSYN-RXN	1 H2O + 1 acetyl-CoA + 1 glyoxylate --> 1 CoA + 1 (S)-malate + 1 H+	EbN1_C04380	2.3.3.9
181	Central carbon metabolism	Glyoxylate shunt, anaplerotic reactions, gluconeogenesis	PEPCARBOX-RXN	TCA-cycle_anaplerotic_4.1.1.31_PEPCARBOX-RXN	1 phosphoenolpyruvate + 1 bicarbonate --> 1 phosphate + 1 oxaloacetate	EbN1_C06250	4.1.1.31
182	Central carbon metabolism	Glyoxylate shunt, anaplerotic reactions, gluconeogenesis	PYRUVATE-CARBOXYLASE-RXN	TCA-cycle_anaplerotic_6.4.1.1_PYRUVATE-CARBOXYLASE-RXN	1 pyruvate + 1 bicarbonate + 1 ATP --> 1 oxaloacetate + 1 ADP + 1 phosphate + 1 H+	EbN1_C33200, EbN1_C33190	6.4.1.1
183	Central carbon metabolism	Pentose phosphate pathway (only non-oxidative branch)	RIBULP3EPIM-RXN	pentose-phosphate-pathway_5.1.3.1_RIBULP3EPIM-RXN	1 D-ribulose_5-phosphate <=> 1 D-xylulose_5-phosphate	EbN1_C23840	5.1.3.1
184	Central carbon metabolism	Pentose phosphate pathway (only non-oxidative branch)	RIB5PISOM-RXN	pentose-phosphate-pathway_5.3.1.6_RIB5PISOM-RXN	1 D-ribose_5-phosphate <=> 1 D-ribulose_5-phosphate	EbN1_C05810	5.3.1.6
185	Central carbon metabolism	Pentose phosphate pathway (only non-oxidative branch)	1TRANSKETO-RXN	pentose-phosphate-pathway_2.2.1.1_1TRANSKETO-RXN	1 D-sedoheptulose_7-phosphate + 1 D-glyceraldehyde_3-phosphate <=> 1 D-ribose_5-phosphate + 1 D-xylulose_5-phosphate	EbN1_C05900	2.2.1.1
186	Central carbon metabolism	Pentose phosphate pathway (only non-oxidative branch)	2TRANSKETO-RXN	pentose-phosphate-pathway_2.2.1.1_2TRANSKETO-RXN	1 D-erythrose_4-phosphate + 1 D-xylulose_5-phosphate <=> 1 D-glyceraldehyde_3-phosphate + 1 D-fructose_6-phosphate	EbN1_C05900	2.2.1.1
187	Central carbon metabolism	Pentose phosphate pathway (only non-oxidative branch)	TRANSALDOL-RXN	pentose-phosphate-pathway_2.2.1.2_TRANSALDOL-RXN	1 D-sedoheptulose_7-phosphate + 1 D-glyceraldehyde_3-phosphate <=> 1 D-fructose_6-phosphate + 1 D-erythrose_4-phosphate	EbN1_C26690	2.2.1.2
188	Central carbon metabolism	Pentose phosphate pathway (only non-oxidative branch)	PRPPSYN-RXN	PRPP-syn_2.7.6.1_PRPPSYN-RXN	1 ATP + 1 D-ribose_5-phosphate <=> 1 H+ + 1 5-phospho-alpha-D-ribose_1-diphosphate + 1 AMP	EbN1_C07760, EbN1_C18300	2.7.6.1
189	Central carbon metabolism	Denitrification	RXN0-6369	nitrate-reduction_1.7.5.1_RXN0-6369	1 ubiquinol-8 + 1 nitrate + 2 H+ --> 1 H2O + 1 ubiquinone-8 + 1 nitrite_ex + 2 H+_ex	EbN1_C36330, EbN1_C36340, EbN1_C36360, EbN1_C36350	1.7.5.1
190	Central carbon metabolism	Denitrification	NITRITE-REDUCTASE-CYTOCHROME-RXN	nitrate-reduction_1.7.2.1_NITRITE-REDUCTASE-CYTOCHROME-RXN	1 Cytochromes-C-Reduced + 2 H+ + 1 nitrite_ex --> 1 H2O + 1 Cytochromes-C-Oxidized + 1 nitric_oxide	EbN1_C04870	1.7.2.1
191	Central carbon metabolism	Denitrification	NITRIC-OXIDE-REDUCTASE-RXN	nitrate-reduction_1.7.2.5_NITRIC-OXIDE-REDUCTASE-RXN	2 nitric_oxide + 2 H+ + 2 Cytochromes-C-Reduced --> 2 Cytochromes-C-Oxidized + 1 H2O + 1 nitrous_oxide	EbN1_C01010, EbN1_C01020	1.7.2.5
192	Central carbon metabolism	Denitrification	RXN-12130	nitrate-reduction_1.7.2.4_RXN-12130	2 H+ + 1 nitrous_oxide + 2 Cytochromes-C-Reduced --> 1 H2O + 2 Cytochromes-C-Oxidized + 1 N2_ex	EbN1_C36290	1.7.2.4
193	Central carbon metabolism	Energy metabolism	NADH-DEHYDROG-A-RXN	respiratory-chain_7.1.1.2_NADH-DEHYDROG-A-RXN	1 NADH + 5 H+ + 1 ubiquinone-8 --> 1 ubiquinol-8 + 1 NAD+ + 4 H+_ex	EbN1_C27720, EbN1_C27770, EbN1_C27670, EbN1_C27750, EbN1_C27690, EbN1_C27700, EbN1_C27730, EbN1_C27650, EbN1_C40060, EbN1_C27660, EbN1_C27710, EbN1_C27760, EbN1_C27740, EbN1_C27680, EbN1_C27780	7.1.1.2
194	Central carbon metabolism	Energy metabolism	NAD	respiratory-chain_1.6.5.2_NQOR-RXN_NAD	1 NADH + 1 H+ + 1 ubiquinone-8 --> 1 NAD+ + 1 ubiquinol-8	EbN1_C12860, EbN1_C41030, EbN1_C28820	1.6.5.2
195	Central carbon metabolism	Energy metabolism	7.1.1.8-RXN	respiratory-chain_7.1.1.8_7.1.1.8-RXN	2 Cytochromes-C-Oxidized + 1 ubiquinol-8 + 2 H+ --> 1 ubiquinone-8 + 2 Cytochromes-C-Reduced	EbN1_C06470, EbN1_C06480, EbN1_C06460	7.1.1.8
196	Central carbon metabolism	Energy metabolism	CYTOCHROME-C-OXIDASE-RXN	respiratory-chain_7.1.1.9_CYTOCHROME-C-OXIDASE-RXN	1 O2 + 4 Cytochromes-C-Reduced + 8 H+ --> 4 Cytochromes-C-Oxidized + 2 H2O + 4 H+_ex	EbN1_C00860, EbN1_C29430, EbN1_C29450, EbN1_C24140, EbN1_C00850, EbN1_C20870, EbN1_C29460, EbN1_C20880, EbN1_C16370, EbN1_C29440, EbN1_C24110, EbN1_C25990, EbN1_C26000, EbN1_C24100	7.1.1.9
197	Central carbon metabolism	Energy metabolism	ATPSYN-RXN	respiratory-chain_ATP-synthesis_7.1.2.2_ATPSYN-RXN	1 ATP + 4 H+ + 1 H2O <=> 1 ADP + 1 phosphate + 4 H+_ex	EbN1_C17090, EbN1_C17050, EbN1_C17070, EbN1_C17120, EbN1_C17080, EbN1_C17060, EbN1_C17110, EbN1_C17100	7.1.2.2
198	Central carbon metabolism	Interconversion reactions	CARBODEHYDRAT-RXN	conv_bicarbonate_4.2.1.1_CARBODEHYDRAT-RXN	1 bicarbonate <=> 1 CO2 + 1 H2O	EbN1_C15950, EbN1_C20750	4.2.1.1
199	Central carbon metabolism	Interconversion reactions	spontaneous	conv_ammonia_RXN-11811_spontaneous	1 NH3 + 1 H+ <=> 1 ammonium			spontaneous

100

Reaction ID	Locus tag
73	EbN1_C07370
74	EbN1_C12150
75	EbN1_C07370
76	EbN1_C28710
77	EbN1_C37950
78	EbN1_C17840
79	EbN1_C02880
80	EbN1_C09560
81	EbN1_C25740
82	EbN1_C23320
83	EbN1_C25910
84	EbN1_C36380
85	EbN1_C32810
86	EbN1_C28490
87	EbN1_C20100
89	EbN1_C40720
90	EbN1_C28650
91	EbN1_C28650
92	EbN1_C30500
93	EbN1_C25680
94	EbN1_C23780
94	EbN1_C23770
94	EbN1_C25220
95	EbN1_C23780
95	EbN1_C23770
95	EbN1_C25220
96	EbN1_C23780
96	EbN1_C23770
96	EbN1_C25220
97	EbN1_C23780
97	EbN1_C23770
97	EbN1_C25220
98	EbN1_PII00560
99	EbN1_PII00560
100	EbN1_C05540
100	EbN1_C05560
100	EbN1_C05550
101	EbN1_C10760
102	EbN1_C15830
103	EbN1_C15830
104	EbN1_C08820
105	EbN1_C28700
106	EbN1_C28090
106	EbN1_C11820
107	EbN1_C12170
107	EbN1_C29600
107	EbN1_C29410
108	EbN1_C23700
109	EbN1_C27620
110	EbN1_C35880
111	EbN1_C28800
112	EbN1_C19970
113	EbN1_C23020
113	EbN1_C20990
114	EbN1_C15390
115	EbN1_C25810
116	EbN1_C26080
117	EbN1_C26080
118	EbN1_C37390
118	EbN1_C32530
119	EbN1_C30460
119	EbN1_C30450
119	EbN1_C30470
120	EbN1_C30460
120	EbN1_C30450
120	EbN1_C30470
121	EbN1_C30460
121	EbN1_C30470
122	EbN1_C29750
123	EbN1_C11610
124	EbN1_C20250
124	EbN1_C20270
125	EbN1_C20250
125	EbN1_C20260
126	EbN1_C03820
126	EbN1_C03810
128	EbN1_C03820
128	EbN1_C03810
129	EbN1_C03820
129	EbN1_C03810
130	EbN1_C03820
130	EbN1_C03810
132	EbN1_C37950
133	EbN1_C37950
134	EbN1_C25910
136	EbN1_C11610
138	EbN1_C11610
140	EbN1_C11610
141	EbN1_C25910
142	EbN1_C11610
144	EbN1_C06580
145	EbN1_C36370
146	EbN1_C25910
147	EbN1_C15990
148	EbN1_C31980
148	EbN1_C15530
148	EbN1_C15540
149	EbN1_C02950
149	EbN1_C02940

100

Reaction ID	EC number
104	7.-.2.-
105	7.3.2.7
106	7.2.2.7
107	7.2.2.8
108	7.2.2.10
109	7.3.2.1
110	7.3.2.3
111	7.3.2.6
112	7.6.2.5
113	7.6.2.-
114	7.3.2.5
116	7.4.2.1
117	7.4.2.1
118	7.4.2.10
152	2.7.1.2
153	5.3.1.9
154	5.3.1.9
155	5.3.1.9
156	5.4.2.2
157	2.7.1.90
158	4.1.2.13
159	5.3.1.1
160	1.2.1.12
161	2.7.2.3
162	5.4.2.11
163	4.2.1.11
164	2.7.1.40
165	2.3.1.12
165	1.2.4.1
165	1.8.1.4
165	1.2.5.1
166	3.1.3.11
167	2.7.9.2
168	1.1.1.40
169	4.1.1.32
170	2.3.3.1
171	4.2.1.3
172	1.1.1.42
173	1.2.7.3
174	1.2.1.105
174	2.3.1.61
174	1.8.1.4
174	1.2.4.2
175	6.2.1.5
176	1.3.5.1
177	4.2.1.2
178	1.1.1.37
179	4.1.3.1
180	2.3.3.9
181	4.1.1.31
182	6.4.1.1
183	5.1.3.1
184	5.3.1.6
185	2.2.1.1
186	2.2.1.1
187	2.2.1.2
188	2.7.6.1
189	1.7.5.1
190	1.7.2.1
191	1.7.2.5
192	1.7.2.4
193	7.1.1.2
194	1.6.5.2
195	7.1.1.8
196	7.1.1.9
197	7.1.2.2
198	4.2.1.1
200	1.17.1.9
201	3.6.1.1
202	3.6.1.11
204	1.8.1.4
205	1.11.1.5
206	1.8.1.9
207	1.5.5.1
212	6.3.2.2
213	6.3.2.3
215	1.1.1.284
216	3.1.2.12
217	3.4.11.1
217	3.4.11.10
218	3.4.19.13
219	2.7.7.4
220	1.8.4.10
221	1.8.1.2
222	1.5.1.3
225	1.5.1.5
226	3.5.4.9
227	1.5.1.3
228	2.7.1.30
229	1.1.5.3
230	2.7.1.165
231	1.1.1.36
233	1.4.1.4
234	1.4.1.2
235	6.3.1.2
236	1.4.1.13
237	2.6.1.57
238	6.3.5.4
239	3.5.1.1

100

Metabolite	Formula	Mol. mass	BRENDA	MetaCyc	KEGG
L-phenylalanine	C9H11O2N1	165.192	98	PHE	C00079
L-tyrosine	C9H11O3N1	181.191	103	TYR	C00082
L-lysine	C6H14O2N2	146.19	128	LYS	C00047
L-isoleucine	C6H13O2N1	131.175	266	ILE	C00407
L-arginine	C6H14O2N4	174.204	117	ARG	C00062
L-threonine	C4H9O3N1	119.12	220	D-THREONINE	C00188
L-tryptophan	C11H12O2N2	204.229	113	TRP	C00078
L-aspartate	C4H7O4N1	133.103	91	L-ASPARTATE	C00049
L-glutamine	C5H10O3N2	146.146	96	GLN	C00064
L-valine	C5H11O2N1	117.148	217	VAL	C00183
L-histidine	C6H9O2N3	155.157	296	HIS	C00135
L-asparagine	C4H8O3N2	132.119	231	ASN	C00152
L-leucine	C6H13O2N1	131.175	121	LEU	C00123
glycine	C2H5O2N1	75.067	68	GLY	C00037
L-cysteine	C3H7O2S1N1	121.154	70	CYS	C00736
L-alanine	C3H7O2N1	89.094	97	5-AMINO-LEVULINATE	C01401
L-methionine	C5H11O2S1N1	149.208	83	MET	C00073
L-proline	C5H9O2N1	115.132	215	PRO	C00148
L-serine	C3H7O3N1	105.093	89	Serines	C00716
L-glutamate	C5H9O4N1	147.13	38	GLT	C00302
O-antigen				O-Antigens
dATP	C10H16P3O12N5	491.183	133	DATP	C00131
dGTP	C10H16P3O13N5	507.182	194	DGTP	C00286
dTTP	C10H17P3O14N2	482.168	137	TTP	C00459
dCTP	C9H16P3O13N3	467.157	161	DCTP	C00458
phosphatidylglycerol	C14H25P1O10R2	384.318	550		C00344
cardiolipin	C25H42P2O17R4	676.542	652	CARDIOLIPIN	C05980
phosphatidylethanolamine	C13H24P1O8N1R2	353.308	427	L-1-GLYCEROPHOSPHORYLETHANOL-AMINE	C00350
a_peptidoglycan_with_D,D_cross-links_(meso-diaminopimelate_containing)
CTP	C9H16P3O14N3	483.156	56	CTP	C00063
GTP	C10H16P3O14N5	523.181	35	GTP	C00044
ATP	C10H16P3O13N5	507.182	7	ATP	C00002
UTP	C9H15P3O15N2	484.14	61	UTP	C00075
pyridoxal_5'-phosphate	C8H11O3N1	169.18	30	PYRIDOXINE	C00018
riboflavin	C17H20O6N4	376.369	298	RIBOFLAVIN	C00255
guanylyl_molybdenum_cofactor	C20H26P2O15Mo1S2N10	868.501	4166	CPD-582	C19871
ubiquinol-8	C49H76O4	729.143	5168	CPD-9956
CoA	C21H36P3O16S1N7	767.534	10	CO-A	C00010
succinyl-CoA	C25H40P3O19S1N7	867.607	198	SUC-COA	C00091
molybdate	O4Mo1	159.946	424	CPD-3	C06232
5-methyl-tetrahydrofolate	C20H25O6N7	459.463	1036	5-METHYL-THF	C00440
acetyl-CoA	C23H38P3O17S1N7	809.571	27	ACETYL-COA	C00024
10-formyl-tetrahydrofolate	C20H23O7N7	473.446	445	10-FORMYL-DIHYDROFOLATE-GLU-N	C00234
putrescine	C4H12N2	88.154	144	PUTRESCINE	C00134
S-adenosyl-L-methionine	C15H22O5S1N6	398.438	22	S-ADENOSYLMETHIONINE	C00019
cytidylylmolybdenum_cofactor
chorismate	C10H10O6	226.184	182	CHORISMATE	C00251
glutathione	C10H17O6S1N3	307.321	41	GLUTATHIONE	C02471
NADPH	C21H30P3O17N7	745.425	5	NADH-P-OR-NOP	C00005
malonyl-CoA	C24H38P3O19S1N7	853.58	72	MALONYL-COA	C00083
NAD+	C21H29P3O17N7	744.417	4	NAD-P-OR-NOP	C00003
thiamin_diphosphate	C10H16P2O11N2	402.189	85	TDP	C00363
NADH	C21H29P2O14N7	665.446	3	NADH	C00004
tetrahydrofolate	C19H23O6N7	445.436	184	THF	C03541
3-demethylubiquinol-8	C48H74O4	715.116	113388	OCTAPRENYL-METHYL-OH-METHOXY-BENZQ	C05815
NADP+	C21H29P3O17N7	744.417	4	NAD-P-OR-NOP	C00003
adenosylcobalamin	C72H102P1Co1O17N18	1581.62	476	ADENOSYLCOBALAMIN	C00194
di-trans,octa-cis-undecaprenyl_diphosphate	C55H92P2O7	927.282	2308	CPD-9649	C04574
uroporphyrinogen-III	C40H44O16N4	836.804	1736	UROPORPHYRINOGEN-III	C02469
FAD	C27H33P2O15N9	785.557	14	FAD	C00016
5,10-methylenetetrahydrofolate	C20H23O6N7	457.447	336	METHYLENE-THF-GLU-N	C00143
H+	H1	1.008	2	PROTON	C00080
H2O	H2O1	18.015	1	WATER	C00001
phosphate	C17H29P1O13R2	472.38	12	L-1-phosphatidyl-inositols	C01194
ADP	C3H5P1O5	152.042	8	3-HYDROHYDROXYPHOSPHORYLPYRUVATE	C06368
NH3	H3N1	17.031	16	AMMONIA	C00014
Fe2+	Fe1	55.845	23	Cytochromes-C550-Red	C14818
Mg2+	Mg1	24.305	25	MG+2	C00305
Co2+	Co1	58.933	21	CO+2	C00175
F-	H1F1	20.006	158	F-	C00742
Cl-	H1Cl1	36.458	134	CL-	C00698
Zn2+	Zn1	65.38	19	ZN+2
3-(4-hydroxyphenyl)propanoate	C9H10O3	166.176	3766	PHLORETATE	C01744
benzoate	C7H1O2R5	117.083	271	Aromatic-Acid	C00539
nitrate	N1O3	62.004	263	NITRATE	C00244
nitrite	H1N1O2	47.013	155	NITRITE	C00088
potassium	K1	39.098	37	K+
acetate	C2H4O2	60.052	44	ACET	C00033
4-ethylphenol	C8H10O1	122.167	2360	CPD-10596	C13637
4-hydroxybenzoate	C7H6O3	138.122	311	4-hydroxybenzoate	C00156
sulfate	H2O4S1	98.072	148	SULFATE	C00059
heme	C34H34O4N4Fe1	618.515	45	CPD-11675	C00032
phenylacetate	C8H8O2	136.15	624	PHENYLACETATE	C00548
phthalate	C8H6O4	166.132	2060	PHTHALATE	C01606
cyclohexanecarboxylate	C7H12O2	128.171	21317	CPD-575	C09822
benzylamine	C7H9N1	107.156	441	BENZYLAMINE	C15562
(indol-3-yl)acetate	C10H9O2N1	175.187	2122	INDOLE_ACETATE_AUXIN	C00954
benzaldehyde	C7H1O1R5	101.084	138	Aryl-Aldehyde	C00193
4-cresol	C8H10O2	138.166	1237	CPD-108	C01468
phenol	C7H8O1	108.14	219	BENZYL-ALCOHOL	C00556
toluene	C7H8	92.141	1011	TOLUENE	C01455
ethylbenzene	C8H10	106.168	2326	ETHYLBENZENE	C07111
3-hydroxybenzoate	C7H6O3	138.122	768	3-HYDROXYBENZOATE	C00587
succinate	C4H6O4	118.088	54	Alpha-omega-dicarboxylates	C04025
3-phenylpropanoate	C9H10O2	150.177	2450	3-PHENYLPROPIONATE	C05629
S-adenosyl-L-homocysteine	C14H20O5S1N6	384.411	34	ADENOSYL-HOMO-CYS	C00021
(S)-malate	C4H6O5	134.087	180	MAL	C00149
fumarate	C4H4O4	116.072	156	FUM	C00122
2-oxoglutarate	C5H6O5	146.098	32	2-KETOGLUTARATE	C00026

100

Metabolite	Reaction-ID
L-phenylalanine	1
L-phenylalanine	36
L-phenylalanine	124
L-phenylalanine	305
L-phenylalanine	692
L-tyrosine	1
L-tyrosine	307
L-tyrosine	676
L-lysine	1
L-lysine	281
L-isoleucine	1
L-isoleucine	294
L-arginine	1
L-arginine	257
L-threonine	1
L-threonine	77
L-threonine	274
L-threonine	290
L-tryptophan	1
L-tryptophan	312
L-aspartate	1
L-aspartate	54
L-aspartate	97
L-aspartate	117
L-aspartate	237
L-aspartate	238
L-aspartate	239
L-aspartate	256
L-aspartate	266
L-aspartate	346
L-aspartate	350
L-aspartate	386
L-aspartate	562
L-aspartate	574
L-aspartate	575
L-glutamine	1
L-glutamine	235
L-glutamine	236
L-glutamine	238
L-glutamine	249
L-glutamine	308
L-glutamine	317
L-glutamine	339
L-glutamine	342
L-glutamine	354
L-glutamine	394
L-glutamine	482
L-glutamine	591
L-glutamine	623
L-glutamine	637
L-glutamine	640
L-glutamine	659
L-valine	1
L-valine	285
L-histidine	1
L-histidine	322
L-histidine	328
L-asparagine	1
L-asparagine	238
L-asparagine	239
L-leucine	1
L-leucine	289
glycine	1
glycine	213
glycine	217
glycine	261
glycine	263
glycine	340
L-cysteine	1
L-cysteine	212
L-cysteine	217
L-cysteine	265
L-cysteine	570
L-cysteine	614
L-cysteine	666
L-cysteine	675
L-alanine	1
L-alanine	22
L-alanine	134
L-alanine	240
L-alanine	241
L-alanine	242
L-alanine	538
L-alanine	614
L-alanine	657
L-alanine	658
L-alanine	666
L-alanine	675
L-methionine	1
L-methionine	275
L-methionine	563
L-methionine	612
L-methionine	630
L-methionine	662
L-methionine	667
L-methionine	676
L-methionine	679
L-proline	1
L-proline	23