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| Accession | Description | Sum PEP Score | Coverage [%] | # Peptides | # PSMs | # Unique Peptides | # AAs | MW [kDa] | Biological Process | Cellular Component | Molecular Function | Entrez Gene ID | Ensembl Gene ID | Gene Symbol | Gene ID | WikiPathways | Reactome Pathways | Abundance Ratio Adj. P-Value: (LQ_16h) / FM | Abundance Ratio Adj. P-Value: (LQ_6h) / FM | Abundance Ratio Adj. P-Value: (SQ_16h) / FM | Abundance Ratio Adj. P-Value: (SQ_6h) / FM | Abundance Ratio Adj. P-Value: (SQ_16h) / (LQ_16h) | Abundance Ratio Adj. P-Value: (LQ_16h) / (LQ_6h) | Abundance Ratio Adj. P-Value: (SQ_6h) / (LQ_6h) | Abundance Ratio Adj. P-Value: (SQ_16h) / (SQ_6h) | Abundances (Normalized): F1: Sample, FM | Abundances (Normalized): F2: Sample, FM | Abundances (Normalized): F3: Sample, FM | Abundances (Normalized): F8: Sample, LQ_16h | Abundances (Normalized): F9: Sample, LQ_16h | Abundances (Normalized): F10: Sample, LQ_16h | Abundances (Normalized): F4: Sample, LQ_6h | Abundances (Normalized): F5: Sample, LQ_6h | Abundances (Normalized): F6: Sample, LQ_6h | Abundances (Normalized): F17: Sample, SQ_16h | Abundances (Normalized): F18: Sample, SQ_16h | Abundances (Normalized): F20: Sample, SQ_16h | Abundances (Normalized): F14: Sample, SQ_6h | Abundances (Normalized): F15: Sample, SQ_6h | Abundances (Normalized): F16: Sample, SQ_6h |
| P62962 | Profilin-1 [OS=Mus musculus] | 63.691 | 91 | 10 | 188 | 10 | 140 | 14.9 | cell organization and biogenesis;developmental processes;other biological processes | non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 18643 | ENSMUSG00000018293 | Pfn1 | mmu:18643; P10924; P62962 | G13 signaling pathway; Regulation of actin cytoskeleton | RHO GTPases Activate Formins; PCP/CE pathway; Signaling by ROBO receptors | 0.411535094328401 | 0.77316053068875 | 0.31701726971249 | 0.946783524828663 | 0.996007724449986 | 0.656158656510427 | 0.877696436885309 | 0.181694204221762 | 655800.017363376 | 143095.091219364 | 419057.751872435 | 4206326.28321379 | 4304878.08309123 | 4747457.58796751 | 1585843.6272586 | 1475995.81484065 | 2000183.41053967 | 7260167.55249118 | 5007652.33533127 | 6263979.57428718 | 1252103.50974388 | 886258.51164894 | 2014688.94704861 |
| P16045 | Galectin-1 [OS=Mus musculus] | 63.154 | 84 | 9 | 160 | 9 | 135 | 14.9 | cell adhesion;signal transduction;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;other cell component | signal transduction activity or receptor binding;other molecular function | 16852 | ENSMUSG00000068220 | Lgals1 | mmu:16852; P05163; P11946; P16045; P17601; Q4FZH4; Q99M27; Q9D0X0 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 0.214793183779243 | 0.758649115689172 | 0.862423503077705 | 0.00322600286143261 | 0.0393290691176906 | 14936.2360725546 | 1.08047842947433E7 | 9599768.14000291 | 8687088.34781577 | 8531853.83491426 | 6908469.78338064 | 7711238.13686352 | 7982203.8536903 | 8824565.06426897 | 7659481.69651213 | 1460635.09603453 | 709314.615558924 | 2150770.87975978 | |||
| O08997 | Copper transport protein ATOX1 [OS=Mus musculus] | 20.78 | 84 | 4 | 42 | 4 | 68 | 7.3 | stress response;transport;other biological processes | cytosol | other molecular function | 11927 | ENSMUSG00000018585 | Atox1 | mmu:11927; O08997; Q5NCU2 | Comprehensive IL-17A signaling | Ion influx/efflux at host-pathogen interface | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.944154202827561 | 0.96786708205164 | 0.557420493212927 | 0.421690313651007 | 551478.266640532 | 313405.851832555 | 677509.482604148 | 306540.186990902 | 295618.985256534 | 331367.2805474 | 971226.606629803 | 627950.630697459 | 441385.272387758 | 96182.1370331154 | 81203.860885215 | 83537.7620395082 | |||
| P70296 | Phosphatidylethanolamine-binding protein 1 [OS=Mus musculus] | 63.309 | 82 | 9 | 96 | 9 | 187 | 20.8 | other biological processes | other cell component | enzyme regulator activity;other molecular function | 23980 | ENSMUSG00000032959 | Pebp1 | mmu:23980; P70296; Q9D8G9; Q9JJ58 | EGFR1 signaling pathway | MAP2K and MAPK activation; Negative regulation of MAPK pathway | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.925217760894268 | 0.809979985251567 | 0.767145247888963 | 0.0682902444293211 | 3469816.49765495 | 3146472.32490885 | 3800847.10397996 | 1755656.74535333 | 1292410.19767497 | 2385194.3198318 | 8075338.47714044 | 6464100.37053227 | 6339151.57068833 | 1267788.46230452 | 783488.191861636 | 1983037.39117649 | |||
| Cont_P02769 | Albumin OS=Bos taurus OX=9913 GN=ALB PE=1 SV=4 | 390.555 | 81 | 57 | 7095 | 54 | 607 | 69.2 | stress response;other biological processes | non-structural extracellular;other cell component | nucleic acid binding activity;other molecular function | 280717 | ALB | A5PJX3; bta:280717; O02787; P02769; P04277; Q3SZR2 | 0.520832629933248 | 0.650544967914241 | 0.598172767155558 | 0.497906326712893 | 0.946568086066385 | 0.413798631523592 | 0.846117085258013 | 0.468531677746422 | 3.41035277502904E9 | 3.06531085647989E9 | 1.66716629813739E9 | 2.0547979326133E9 | 2.37062763488737E9 | 2.78500610382043E9 | 3.09362764542436E9 | 2.55631644026836E9 | 3.07992745656962E9 | 2.97814649224141E9 | 2.86277256421772E9 | 2.21144220575444E9 | 1.66052966718895E9 | 2.22855277531216E9 | 3.25384623573346E9 | |||
| Q01149 | Collagen alpha-2(I) chain [OS=Mus musculus] | 773.662 | 80 | 66 | 1731 | 51 | 1372 | 129.5 | cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12843 | ENSMUSG00000029661 | Col1a2 | mmu:12843; Q01149; Q8CGA5 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Focal adhesion | Crosslinking of collagen fibrils; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; ECM proteoglycans; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; GPVI-mediated activation cascade; GP1b-IX-V activation signalling; Platelet Adhesion to exposed collagen; Platelet Aggregation (Plug Formation); MET activates PTK2 signaling | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.0150838661305169 | 0.862063111456553 | 0.0347692006632991 | 0.926292871155025 | 217896.573253055 | 102775.453905646 | 225868.955510701 | 3.82374533805921E8 | 3.80614155239716E8 | 2.79801552870279E8 | 1.73556920519588E8 | 1.55763113653521E8 | 1.89931753802048E8 | 1.03217412397752E8 | 1.04517075360638E8 | 6.33578194684048E7 | 4.96147162399626E7 | 2.65479311979207E7 | 5.19818116295111E7 |
| P11087 | Collagen alpha-1(I) chain [OS=Mus musculus] | 797.017 | 79 | 75 | 1933 | 35 | 1453 | 137.9 | cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12842 | ENSMUSG00000001506 | Col1a1 | mmu:12842; P11087; Q53WT0; Q60635; Q61367; Q61427; Q63919; Q6PCL3; Q810J9 | Osteoblast signaling; Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Comprehensive IL-17A signaling; Focal adhesion | Cell surface interactions at the vascular wall; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ECM proteoglycans; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; GPVI-mediated activation cascade; GP1b-IX-V activation signalling; Platelet Adhesion to exposed collagen; Platelet Aggregation (Plug Formation); MET activates PTK2 signaling | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 1.58880673198775E-4 | 0.381922652011049 | 0.0629214061377862 | 0.655833157547641 | 703080.609341466 | 1047026.5902454 | 567207.050774397 | 6.12803341835757E8 | 6.28616080368892E8 | 5.37143706349406E8 | 2.20652487774689E8 | 1.86114398805651E8 | 2.17194307013081E8 | 9.46570689754052E7 | 9.72166914362706E7 | 6.09758172025116E7 | 6.01286898886734E7 | 4.84358218594371E7 | 7.06441702532683E7 |
| Cont_P35908 | Keratin, type II cytoskeletal 2 epidermal OS=Homo sapiens OX=9606 GN=KRT2 PE=1 SV=2 | 284.975 | 78 | 42 | 1022 | 32 | 639 | 65.4 | cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes | plasma membrane;cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;cytoskeletal activity | 3849 | ENSG00000172867 | KRT2 | hsa:3849; P35908; Q4VAQ2 | Formation of the cornified envelope | 0.499413631103761 | 0.411258958244596 | 0.544106843431104 | 0.933570718645937 | 0.912218866069753 | 0.862063111456553 | 0.309041843038519 | 2.9837536993241E-4 | 2.56957016834685E7 | 6.51011422173888E7 | 5.25056794690703E7 | 3.16465014359267E7 | 4.04662454773149E7 | 3.03458785296059E7 | 2.58420950665494E7 | 4.44581259999837E7 | 1.77732081549674E7 | 3.88601529372083E7 | 2.41897353529024E7 | 4.54682916268081E7 | 9.79668081708945E7 | 6.73715830359901E7 | 6.38856203067551E7 | |
| Cont_Q29443 | Serotransferrin OS=Bos taurus OX=9913 GN=TF PE=2 SV=1 | 343.183 | 74 | 48 | 1709 | 46 | 704 | 77.7 | stress response;transport;other biological processes | non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle | other molecular function | 280705 | TF | bta:280705; Q0IIK2; Q29443 | 0.615274986253429 | 0.964709887217926 | 0.600414647182016 | 0.571407162236119 | 0.902231721267411 | 0.105569810421019 | 0.506704636011438 | 0.313748671859839 | 1.71679936327392E8 | 1.91001417946965E8 | 8.41149187199369E7 | 1.24867801818358E8 | 1.55146358811954E8 | 1.88178132242021E8 | 2.69795837029218E8 | 2.21755859229163E8 | 2.04768415701638E8 | 1.81082969779594E8 | 1.61167381210782E8 | 1.45463022007429E8 | 9.18433757916485E7 | 1.38609619584445E8 | 1.76572700073531E8 | |||
| P99027 | Large ribosomal subunit protein P2 [OS=Mus musculus] | 36.307 | 74 | 5 | 72 | 5 | 115 | 11.6 | protein metabolism;other metabolic processes | cytosol;translational apparatus;other cell component | other molecular function | 67186 | ENSMUSG00000025508 | Rplp2 | mmu:67186; P99027; Q3TKY3; Q9CQ99; Q9CZJ8 | Cytoplasmic ribosomal proteins | L13a-mediated translational silencing of Ceruloplasmin expression; SRP-dependent cotranslational protein targeting to membrane; Major pathway of rRNA processing in the nucleolus and cytosol; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.946568086066385 | 0.802315371714662 | 0.903936753250945 | 0.564848371108574 | 3399041.07520174 | 2851850.82913075 | 1601733.69914465 | 815551.673033217 | 867258.498357774 | 1625084.65937807 | 3955346.77360562 | 3509370.78947096 | 3554677.37975841 | 934269.224357541 | 392156.368890257 | 1254701.48751756 | |||
| Q9WVA4 | Transgelin-2 [OS=Mus musculus] | 49.237 | 71 | 12 | 144 | 10 | 199 | 22.4 | other biological processes | 21346 | ENSMUSG00000026547 | Tagln2 | mmu:21346; Q3TIB8; Q6A0C6; Q78ZX2; Q91VU2; Q9WVA4 | Platelet degranulation | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.940322254515829 | 0.994834213681465 | 0.85946611802464 | 0.399575694869052 | 3338415.96286452 | 2945418.24069324 | 1595032.39267318 | 1301091.15891193 | 1408632.10380685 | 2044292.87913917 | 6921646.04957812 | 5275332.74892481 | 3601520.96428178 | 1243484.77656065 | 738774.329736027 | 1658740.06520302 | ||||||
| P02463 | Collagen alpha-1(IV) chain [OS=Mus musculus] | 487.707 | 70 | 68 | 828 | 68 | 1669 | 160.6 | cell organization and biogenesis;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix | extracellular structural activity;other molecular function | 12826 | ENSMUSG00000031502 | Col4a1 | mmu:12826; P02463; Q3UHJ4; Q3UJE7; Q3UQV2; Q53X35; Q6GQS7; Q6PHB5; Q99LQ8 | Spinal cord injury; Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Laminin interactions; Signaling by PDGF; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions | 0.604225174343649 | 0.68008321917751 | 0.284160251285083 | 0.936818656936794 | 0.483508479481234 | 0.167300285011781 | 0.777395712279767 | 0.224623005929948 | 359769.877634713 | 285958.835932462 | 141085.539092917 | 2.00868956379824E7 | 2.17854047157598E7 | 2.25190928918174E7 | 4657081.16483192 | 4119739.1632835 | 5084724.84322114 | 3.91843343162395E7 | 3.69562703398771E7 | 2.33283395840594E7 | 7286914.931104 | 6193195.94075903 | 1.32557370999003E7 |
| Cont_P60712 | Actin, cytoplasmic 1 OS=Bos taurus OX=9913 GN=ACTB PE=1 SV=1 | 225.45 | 70 | 19 | 852 | 2 | 375 | 41.7 | cell organization and biogenesis;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component | enzyme regulator activity;cytoskeletal activity;other molecular function | 100033878; 100135470; 100173832; 101844587; 102139853; 11461; 118833809; 280979; 396526; 403580; 414396; 443052; 450133; 60; 81822 | ENSBTAG00000026199; ENSCAFG00000016020; ENSCAFG00030015381; ENSCAFG00040015695; ENSCPOG00000013467; ENSG00000075624; ENSMAUG00000008763; ENSMUSG00000029580; ENSOARG00040012985; ENSOARG00180022443; ENSOARG00185023855; ENSOARG00215030140; ENSOARG00225009314; ENSPPYG00000017336; ENSPTRG00000018890; ENSRNOG00000034254; ENSSSCG00000007585; ENSSSCG00030003451; ENSSSCG00035038792; ENSSSCG00040049462; ENSSSCG00045027458; ENSSSCG00050065025; ENSSSCG00055012597; ENSSSCG00060019124; ENSSSCG00065037921; ENSSSCG00070011353; ENSSSCG00105030144; ENSSSCG00110026965; ENSSSCG00115013637; ENSSSCG00130033784 | Actb; ACTB | A5D961; A5PKA1; bta:280979; cfa:403580; cpoc:100135470; csab:103246953; ecb:100033878; gga:396526; hsa:60; maua:101844587; mmu:11461; O18840; oas:443052; P02570; P60706; P60707; P60708; P60709; P60710; P60711; P60712; P60713; P70514; P99021; pon:100173832; ptr:450133; Q11209; Q11211; Q3SZD2; Q3TI89; Q3TVP6; Q4L0Y2; Q4R561; Q5R1X3; Q5R582; Q5R6G0; Q64316; Q6QAQ1; Q6ZWM3; Q711N9; Q71FK5; Q75MN2; Q76N69; Q8MIJ0; Q8SPX4; Q95164; Q96B34; Q96HG5; rno:81822; ssc:414396 | FAS pathway and stress induction of HSP regulation; Actin cytoskeleton regulation; Myometrial relaxation and contraction pathways; Focal adhesion; Arrhythmogenic right ventricular cardiomyopathy; Pathogenic Escherichia coli infection; Common pathways underlying drug addiction; Myometrial relaxation and contraction pathways; Focal adhesion; Fas ligand pathway and stress induction of heat shock proteins; Pathogenic Escherichia coli infection; Arrhythmogenic right ventricular cardiomyopathy; Focal adhesion; Myometrial relaxation and contraction pathways; Regulation of actin cytoskeleton; Myometrial relaxation and contraction pathways; Ebola virus infection in host; Acute viral myocarditis; Thermogenesis; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Overlap between signal transduction pathways contributing to LMNA laminopathies; Pleural mesothelioma; Regulation of actin cytoskeleton; Network map of SARS-CoV-2 signaling; Regulation of actin cytoskeleton; Regulation of actin cytoskeleton; Focal adhesion | Formation of the canonical BAF (cBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); Regulation of actin dynamics for phagocytic cup formation; EPH-ephrin mediated repulsion of cells; Formation of annular gap junctions; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; RHO GTPases Activate Formins; RHOF GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; B-WICH complex positively regulates rRNA expression; Regulation of CDH1 Function; Formation of the dystrophin-glycoprotein complex (DGC); Formation of the canonical BAF (cBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); RHO GTPases Activate WASPs and WAVEs; UCH proteinases; DNA Damage Recognition in GG-NER; Formation of the non-canonical BAF (ncBAF) complex; RHO GTPases activate IQGAPs; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Cell-extracellular matrix interactions; MAP2K and MAPK activation; Interaction between L1 and Ankyrins; RHOF GTPase cycle; DNA Damage Recognition in GG-NER; MAP2K and MAPK activation; RHO GTPases Activate Formins; Clathrin-mediated endocytosis; UCH proteinases; RHOF GTPase cycle; DNA Damage Recognition in GG-NER; EPH-ephrin mediated repulsion of cells; VEGFA-VEGFR2 Pathway; Regulation of actin dynamics for phagocytic cup formation; Adherens junctions interactions; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); RHO GTPases Activate WASPs and WAVEs; B-WICH complex positively regulates rRNA expression; Regulation of CDH1 Function; EPHB-mediated forward signaling; Formation of the non-canonical BAF (ncBAF) complex; Formation of the canonical BAF (cBAF) complex; Formation of annular gap junctions; RHO GTPases activate IQGAPs; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; RHO GTPases Activate WASPs and WAVEs; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RHO GTPases activate IQGAPs; RHO GTPases Activate Formins; RHOF GTPase cycle; Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs); B-WICH complex positively regulates rRNA expression; Signaling by BRAF and RAF1 fusions; UCH proteinases; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; VEGFA-VEGFR2 Pathway; Formation of the dystrophin-glycoprotein complex (DGC); Factors involved in megakaryocyte development and platelet production; Regulation of MITF-M-dependent genes involved in pigmentation; Formation of the canonical BAF (cBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); EPH-ephrin mediated repulsion of cells; HATs acetylate histones; Interaction between L1 and Ankyrins; Prefoldin mediated transfer of substrate to CCT/TriC; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Adherens junctions interactions; Regulation of CDH1 Function; Formation of the non-canonical BAF (ncBAF) complex; DNA Damage Recognition in GG-NER; Formation of the polybromo-BAF (pBAF) complex; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Formation of annular gap junctions; Folding of actin by CCT/TriC; Cell-extracellular matrix interactions; MAP2K and MAPK activation; RHO GTPases Activate Formins; Recycling pathway of L1; RHO GTPases activate IQGAPs; Clathrin-mediated endocytosis; Formation of the dystrophin-glycoprotein complex (DGC); EPHB-mediated forward signaling; UCH proteinases; B-WICH complex positively regulates rRNA expression; Adherens junctions interactions; Formation of the non-canonical BAF (ncBAF) complex; Formation of annular gap junctions; Formation of the polybromo-BAF (pBAF) complex; VEGFA-VEGFR2 Pathway; Cell-extracellular matrix interactions; RHO GTPases Activate WASPs and WAVEs; Regulation of CDH1 Function; Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; UCH proteinases; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); Formation of the polybromo-BAF (pBAF) complex; B-WICH complex positively regulates rRNA expression; DNA Damage Recognition in GG-NER; Formation of the canonical BAF (cBAF) complex; RHO GTPases Activate Formins; Regulation of CDH1 Function; Interaction between L1 and Ankyrins; RHOF GTPase cycle; Formation of the non-canonical BAF (ncBAF) complex; Adherens junctions interactions; Formation of the dystrophin-glycoprotein complex (DGC); VEGFA-VEGFR2 Pathway; RHO GTPases Activate WASPs and WAVEs; Cell-extracellular matrix interactions; EPHB-mediated forward signaling; MAP2K and MAPK activation; Recycling pathway of L1; RHO GTPases activate IQGAPs; Formation of annular gap junctions; B-WICH complex positively regulates rRNA expression; UCH proteinases; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); MAP2K and MAPK activation; Formation of the polybromo-BAF (pBAF) complex; RHO GTPases Activate Formins; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases Activate WASPs and WAVEs; Formation of the dystrophin-glycoprotein complex (DGC); VEGFA-VEGFR2 Pathway; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; DNA Damage Recognition in GG-NER; RHOF GTPase cycle; Cell-extracellular matrix interactions; Adherens junctions interactions; Formation of the non-canonical BAF (ncBAF) complex; Formation of the canonical BAF (cBAF) complex; RHO GTPases activate IQGAPs; Regulation of CDH1 Function; Gap junction degradation; Formation of annular gap junctions; Regulation of actin dynamics for phagocytic cup formation; RHOF GTPase cycle; Clathrin-mediated endocytosis; RHO GTPases Activate Formins; Cell-extracellular matrix interactions; VEGFA-VEGFR2 Pathway; Adherens junctions interactions; RHO GTPases activate IQGAPs; UCH proteinases; EPHB-mediated forward signaling; MAP2K and MAPK activation; RHO GTPases Activate WASPs and WAVEs; Formation of the dystrophin-glycoprotein complex (DGC); Formation of annular gap junctions; Formation of the canonical BAF (cBAF) complex; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of the non-canonical BAF (ncBAF) complex; Regulation of CDH1 Function | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.946568086066385 | 0.994348552930242 | 0.963278515868644 | 0.938282411159324 | 1924782.99006244 | 2098949.09709163 | 1966246.27612296 | 6.9333476629433E7 | 7.92679608662888E7 | 4.66219167617927E7 | 4.31411746831055E7 | 4.48147974340301E7 | 5.69102455002969E7 | 1.21577893646273E8 | 1.207324829685E8 | 8.72162161647777E7 | 5.58171302270344E7 | 3.75040107769213E7 | 6.67519874410893E7 |
| P63260 | Actin, cytoplasmic 2 [OS=Mus musculus] | 217.791 | 70 | 19 | 831 | 2 | 375 | 41.8 | cell organization and biogenesis;stress response;developmental processes;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 11465 | ENSMUSG00000062825 | Actg1 | mmu:11465; P02571; P14104; P63260; P99022 | Myometrial relaxation and contraction pathways; Regulation of actin cytoskeleton; Focal adhesion | Platelet degranulation ; RHO GTPases activate IQGAPs; Adherens junctions interactions; Regulation of CDH1 Function; RHO GTPases Activate Formins; Regulation of actin dynamics for phagocytic cup formation; Interaction between L1 and Ankyrins; MAP2K and MAPK activation; Recycling pathway of L1; Clathrin-mediated endocytosis; Formation of the dystrophin-glycoprotein complex (DGC); EPHB-mediated forward signaling; RHOF GTPase cycle; Formation of annular gap junctions; VEGFA-VEGFR2 Pathway; Cell-extracellular matrix interactions; RHO GTPases Activate WASPs and WAVEs; RHOBTB2 GTPase cycle | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.85271451854395 | 0.901789796153066 | 0.731487178650893 | 0.819844267712751 | 345218.530665522 | 243712.893345201 | 175067.879334021 | 138179.400499307 | 114235.784978709 | 184680.44906409 | 283414.957020267 | 357431.419092683 | 129167.257177683 | 191405.076269325 | 47386.9835565671 | 139954.449837086 | |||
| Cont_P35527 | Keratin, type I cytoskeletal 9 OS=Homo sapiens OX=9606 GN=KRT9 PE=1 SV=3 | 310.424 | 69 | 35 | 915 | 34 | 623 | 62 | cell organization and biogenesis;other biological processes | cytosol;cytoskeleton | cytoskeletal activity | 3857 | ENSG00000171403 | KRT9 | hsa:3857; O00109; P35527; Q0IJ47; Q14665 | Formation of the cornified envelope | 0.836660982916281 | 0.73072258897653 | 0.769556732848094 | 0.964570089320365 | 0.873609880131656 | 0.936669139837906 | 0.516448827835279 | 0.0110179641295352 | 3.00988862408693E7 | 2.22166955848562E7 | 3.53566605858277E7 | 3.83413938796298E7 | 4.01115354911529E7 | 4.55013850626263E7 | 3.25056930591839E7 | 3.99576081794461E7 | 2.50556157717982E7 | 4.79768166310243E7 | 2.93517742058567E7 | 7.69722436015544E7 | 1.31711700890849E8 | 9.27838604678364E7 | 5.6604390657593E7 | |
| Q91XV3 | Brain acid soluble protein 1 [OS=Mus musculus] | 84.613 | 69 | 9 | 121 | 9 | 226 | 22.1 | cell organization and biogenesis;developmental processes;other biological processes | plasma membrane;other membranes;nucleus;other cell component | nucleic acid binding activity;other molecular function | 70350 | ENSMUSG00000045763 | Basp1 | mmu:70350; Q91XV3 | RHOF GTPase cycle | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.850917681937748 | 0.865068878287396 | 0.948217415754165 | 0.849720620922415 | 1362011.11927008 | 1239340.97150253 | 1139072.73906572 | 564179.391534735 | 418599.607605535 | 582574.563182137 | 1108632.8864165 | 1270864.18619749 | 1068336.33315507 | 463559.386600798 | 382606.111084956 | 595292.168478121 | ||||
| Cont_P02081 | Hemoglobin fetal subunit beta OS=Bos taurus OX=9913 PE=1 SV=1 | 43.765 | 68 | 8 | 139 | 6 | 145 | 15.8 | other metabolic processes;transport;other biological processes | cytosol;other cell component | other molecular function | 0.364531904426892 | 0.2358261286618 | 0.463293082086092 | 0.328798481418023 | 0.950181954292864 | 0.881605220380855 | 0.937453377971347 | 0.622880861621114 | 9422687.49258887 | 6719727.86898196 | 5803890.24825753 | 4330686.53493356 | 6069450.23888522 | 4560292.30446579 | 4208206.42375347 | 4999214.25928966 | 4980503.25605162 | 6267204.81532326 | 7274768.41367181 | 5310722.09413616 | 4854825.1254444 | 3672226.77101208 | 8140551.6958571 | ||||||
| Q64433 | 10 kDa heat shock protein, mitochondrial [OS=Mus musculus] | 22.229 | 68 | 7 | 79 | 7 | 102 | 11 | protein metabolism;other metabolic processes | mitochondrion | other molecular function | 15528 | ENSMUSG00000073676 | Hspe1 | mmu:15528; Q64433 | RHOG GTPase cycle | 0.0917887729959558 | 0.0985125100188838 | 1.50457038391225E-17 | 0.1367389692144 | 0.87421335771164 | 0.871988363152002 | 0.856588419539538 | 0.875615554962516 | 20207.2996090432 | 1795033.79531347 | 1607088.74701353 | 1185753.77744954 | 1208151.89897442 | 865168.617058511 | 1523660.54306772 | 4432959.24831459 | 3210911.86048977 | 2832747.94626442 | 1942010.17282691 | 1242096.25679038 | 2024337.60877693 | |||
| P62259 | 14-3-3 protein epsilon [OS=Mus musculus] | 93.019 | 67 | 15 | 341 | 12 | 255 | 29.2 | stress response;developmental processes;signal transduction;other biological processes | plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component | enzyme regulator activity;other molecular function | 22627 | ENSMUSG00000020849 | Ywhae | mmu:22627; P29360; P42655; P62259; Q63631 | Myometrial relaxation and contraction pathways; Alpha 6 beta 4 integrin signaling pathway; Calcium regulation in cardiac cells | Regulation of HSF1-mediated heat shock response; RAB GEFs exchange GTP for GDP on RABs; Anchoring of the basal body to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; AURKA Activation by TPX2; TP53 Regulates Metabolic Genes; Activation of BAD and translocation to mitochondria ; RHO GTPases activate PKNs; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; NADE modulates death signalling; HSF1 activation; Signaling by Hippo | 1.65082956259427E-17 | 0.0173918608014292 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.953971000771159 | 0.98558531112136 | 0.961808375473893 | 0.883926343986088 | 17484.8546140728 | 10297.8320593379 | 6972319.65330627 | 5321697.90530677 | 5559653.43929525 | 3693380.77710522 | 2883022.50548721 | 4603672.2345604 | 1.25121635794151E7 | 1.06282269423704E7 | 6851231.05274656 | 3265608.73363903 | 3608346.70770129 | 4009646.14865423 | |
| P63242 | Eukaryotic translation initiation factor 5A-1 [OS=Mus musculus] | 44.4 | 67 | 8 | 104 | 8 | 154 | 16.8 | protein metabolism;other metabolic processes;signal transduction;other biological processes | other membranes;ER/Golgi;nucleus;other cell component | translation activity;nucleic acid binding activity;other molecular function | 276770 | ENSMUSG00000078812 | Eif5a | mmu:276770; P10159; P63242; Q16182; Q5NCX0; Q78NR3; Q9D0G2 | Translation factors | Hypusine synthesis from eIF5A-lysine | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.946568086066385 | 0.904392641853656 | 0.707919361302678 | 0.339769890517243 | 32548.1388735909 | 12070.9754086567 | 14199.4978081733 | 4056489.1475094 | 3818571.6736153 | 3350040.06754225 | 1712110.43069843 | 1306518.98956364 | 2541344.4118 | 6518632.70704459 | 4599568.23171138 | 3986162.98822878 | 1376510.71105031 | 627604.7215701 | 1555010.40646564 |
| Q9DAS9 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [OS=Mus musculus] | 12.396 | 67 | 4 | 25 | 4 | 72 | 8 | signal transduction | plasma membrane;other membranes;other cell component | other molecular function | 14701 | ENSMUSG00000036402 | Gng12 | mmu:14701; Q544P3; Q9DAS9 | Chemokine signaling pathway; G protein signaling pathways; Focal adhesion: PI3K-Akt-mTOR signaling pathway; Myometrial relaxation and contraction pathways; Regulation of actin cytoskeleton; Comprehensive IL-17A signaling; Calcium regulation in cardiac cells | GPER1 signaling; G alpha (i) signalling events; G alpha (q) signalling events; G alpha (12/13) signalling events; Ca2+ pathway; G beta:gamma signalling through PLC beta; Presynaptic function of Kainate receptors; ADP signalling through P2Y purinoceptor 12; Adrenaline,noradrenaline inhibits insulin secretion; Extra-nuclear estrogen signaling; G alpha (s) signalling events; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Vasopressin regulates renal water homeostasis via Aquaporins; Thromboxane signalling through TP receptor; High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells; Thrombin signalling through proteinase activated receptors (PARs); G-protein activation; Glucagon-type ligand receptors; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; G alpha (z) signalling events; G beta:gamma signalling through CDC42; Activation of G protein gated Potassium channels; Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits; ADP signalling through P2Y purinoceptor 1; G beta:gamma signalling through PI3Kgamma; Prostacyclin signalling through prostacyclin receptor; G beta:gamma signalling through BTK | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.657172914271921 | 0.946089070010067 | 0.199089132024186 | 0.600286749244923 | 150301.328499015 | 145925.433353311 | 126571.081453404 | 98299.5154117686 | 73601.0426250543 | 100630.198416078 | 540680.918983182 | 520505.154777131 | 397389.57923426 | 293399.407536829 | 243101.117339139 | 346427.369861065 | |||
| P05064 | Fructose-bisphosphate aldolase A [OS=Mus musculus] | 112.015 | 66 | 18 | 261 | 18 | 364 | 39.3 | cell organization and biogenesis;other metabolic processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | other molecular function | 11674 | ENSMUSG00000030695 | Aldoa | mmu:11674; P05064 | Glycolysis and gluconeogenesis | Platelet degranulation ; Neutrophil degranulation; Gluconeogenesis; Glycolysis | 0.101571037453114 | 0.00616383846364181 | 1.50457038391225E-17 | 0.0771819601934254 | 0.907383519445145 | 0.828577692034317 | 0.988377544628277 | 0.953305976192702 | 36553.7681309936 | 18014.3910425567 | 11156.0078725057 | 5538849.24179232 | 5285372.3367409 | 3856062.26656154 | 4263443.39983126 | 3386915.16711964 | 5306808.16889341 | 1.24814165546298E7 | 1.09515793948855E7 | 8528808.13475854 | 4192052.54158905 | 4075248.71161469 | 5289067.55868911 |
| P63101 | 14-3-3 protein zeta/delta [OS=Mus musculus] | 85.805 | 66 | 15 | 289 | 10 | 245 | 27.8 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | cytosol;nucleus;other cell component | other molecular function | 22631 | ENSMUSG00000022285 | Ywhaz | mmu:22631; P35215; P63101; P70197; P97286; Q3TSF1; Q5EBQ1 | IL-5 signaling pathway; IL-3 signaling pathway; Myometrial relaxation and contraction pathways; Alpha 6 beta 4 integrin signaling pathway; Calcium regulation in cardiac cells | TP53 Regulates Metabolic Genes; Activation of BAD and translocation to mitochondria ; RHO GTPases activate PKNs; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Rap1 signalling; GP1b-IX-V activation signalling; Interleukin-3, Interleukin-5 and GM-CSF signaling; Deactivation of the beta-catenin transactivating complex; Regulation of localization of FOXO transcription factors; NOTCH4 Activation and Transmission of Signal to the Nucleus; KSRP (KHSRP) binds and destabilizes mRNA | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.873755746039336 | 0.951563041423324 | 0.93482524409719 | 0.834163773575342 | 69535.8255809738 | 78847.9582112583 | 121989.790212482 | 1.07849176812864E7 | 9528517.79491501 | 8611576.97108304 | 5842325.28248147 | 4318908.58658828 | 7802439.53918656 | 2.58328839558383E7 | 1.99446241396289E7 | 1.50672257583468E7 | 6273918.76396034 | 5788855.71917891 | 8261103.25502296 |
| P18760 | Cofilin-1 [OS=Mus musculus] | 45.438 | 66 | 11 | 115 | 9 | 166 | 18.5 | cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;other molecular function | 12631 | ENSMUSG00000056201 | Cfl1 | mmu:12631; P18760 | G13 signaling pathway; Regulation of actin cytoskeleton | 0.346629783740056 | 0.26014877424013 | 0.362534518179133 | 0.412112821448938 | 0.945784131099142 | 0.931377691493433 | 0.870511801558508 | 0.647305095960454 | 4493954.17011393 | 5680138.4933051 | 6595908.45258571 | 1.11742389075122E7 | 1.01176598053604E7 | 8215200.73172656 | 8508248.77221218 | 8522369.80126875 | 1.02216677753501E7 | 1.73872199360457E7 | 1.6027940160356E7 | 1.45862421226393E7 | 1.08058843528415E7 | 1.054037483293E7 | 7896767.12653757 | |
| Cont_P04264 | Keratin, type II cytoskeletal 1 OS=Homo sapiens OX=9606 GN=KRT1 PE=1 SV=6 | 306.58 | 65 | 45 | 1774 | 36 | 644 | 66 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;other molecular function | 3848 | ENSG00000167768 | KRT1 | B2RA01; hsa:3848; P04264; P85925; P86104; Q14720; Q6GSJ0; Q9H298 | Corticotropin-releasing hormone signaling | Formation of the cornified envelope; Neutrophil degranulation; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.65780924735352 | 0.653826967689551 | 0.631165145316661 | 0.89629386854896 | 0.873609880131656 | 0.770634810212039 | 0.254077056479593 | 5.78940441291519E-5 | 1.31038801811221E8 | 1.49848314576813E8 | 1.81048519054156E8 | 1.64179912336924E8 | 1.70861004616453E8 | 1.60803236136221E8 | 1.32005397364365E8 | 1.61355773356369E8 | 1.09071204525108E8 | 1.84835731298625E8 | 1.38277867637903E8 | 2.0582953187505E8 | 6.47574942932283E8 | 3.95085049343759E8 | 3.00261678765842E8 |
| P15532 | Nucleoside diphosphate kinase A [OS=Mus musculus] | 49.516 | 64 | 9 | 178 | 5 | 152 | 17.2 | DNA metabolism;other metabolic processes;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle | translation activity;kinase activity;other molecular function | 18102 | ENSMUSG00000037601 | Nme1 | mmu:18102; P15532 | Purine metabolism | Azathioprine ADME; Interconversion of nucleotide di- and triphosphates; Ribavirin ADME | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.801576044337039 | 0.696358249006924 | 0.901149690306505 | 0.779071785728112 | 9564.24332396852 | 9206.73320544476 | 3592.15162523004 | 1.23866008536714E7 | 1.67366102660244E7 | 1.816742187365E7 | 5355631.14226611 | 4397707.11715414 | 6010321.56949385 | 1.35828724863268E7 | 1.6112953410397E7 | 1.16190055374183E7 | 3932460.71076704 | 2871882.80172497 | 7369907.5842535 |
| P10107 | Annexin A1 [OS=Mus musculus] | 115.566 | 64 | 18 | 270 | 18 | 346 | 38.7 | cell organization and biogenesis;stress response;transport;signal transduction;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component | enzyme regulator activity;other molecular function | 16952 | ENSMUSG00000024659 | Anxa1 | mmu:16952; P10107 | Spinal cord injury; Prostaglandin synthesis and regulation | G alpha (q) signalling events; G alpha (i) signalling events; Formyl peptide receptors bind formyl peptides and many other ligands | 1.65082956259427E-17 | 0.105053536950499 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.954328834404239 | 0.401885831342676 | 0.529099828181544 | 0.924766494197286 | 13280.9290610842 | 9160.53166722029 | 4508.77124840677 | 5251880.61554565 | 6740833.31198439 | 6058745.6526555 | 1560362.01883491 | 1521121.84391776 | 1946127.08618424 | 1.11990207127477E7 | 1.0990927807692E7 | 1.0321301103113E7 | 4605609.45936174 | 3223846.7434476 | 4805492.80063037 |
| Q3U962 | Collagen alpha-2(V) chain [OS=Mus musculus] | 518.514 | 64 | 57 | 817 | 55 | 1497 | 144.9 | cell organization and biogenesis;developmental processes;other biological processes | extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12832 | ENSMUSG00000026042 | Col5a2 | mmu:12832; Q3TVR2; Q3U962; Q3UHK7; Q3UTT4; Q3V1J6; Q61431; Q7TMS0; Q80VS8 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions | 0.861384746267066 | 0.961254912149485 | 0.730324052254867 | 0.632833892117728 | 0.0769666553885184 | 0.273444295895674 | 0.453486790198347 | 0.973358018692255 | 1.96082795853326E7 | 1.89754303457921E7 | 3.46758133166589E7 | 4.80275081428664E7 | 4.79991185130461E7 | 4.1747532446715E7 | 1.59204573672189E7 | 1.42782577106181E7 | 1.7061559679881E7 | 2.09575588581227E7 | 1.96948053072084E7 | 2.25862916575107E7 | 1.85137908486988E7 | 4881772.8383399 | 8018525.34642114 |
| P08122 | Collagen alpha-2(IV) chain [OS=Mus musculus] | 526.992 | 64 | 69 | 1077 | 69 | 1707 | 167.2 | RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix | extracellular structural activity | 12827 | ENSMUSG00000031503 | Col4a2 | mmu:12827; P08122; Q3B7C2; Q3TPV9; Q61375; Q66JS5; Q6RCT6; Q6RCT7; Q6U9X1; Q8BPI9; Q8BPK3; Q91VI3 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Focal adhesion | Laminin interactions; Signaling by PDGF; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions | 0.352816378116182 | 0.64759425713406 | 0.293387877727491 | 0.79866917976589 | 0.979628232635575 | 0.169673447599406 | 0.959159975702413 | 0.483015668880262 | 1499335.01530309 | 1691518.00623855 | 989751.415380184 | 5.53234274481973E7 | 5.88619201086468E7 | 3.63990683013196E7 | 1.35123643610626E7 | 1.30555597235297E7 | 1.53773176128868E7 | 6.80333035906639E7 | 6.55922447276284E7 | 4.55601360762201E7 | 1.71661195678148E7 | 9511844.25395737 | 2.43703078917008E7 |
| P08249 | Malate dehydrogenase, mitochondrial [OS=Mus musculus] | 76.52 | 64 | 17 | 185 | 17 | 338 | 35.6 | other metabolic processes | other membranes;mitochondrion | other molecular function | 17448 | ENSMUSG00000019179 | Mdh2 | mmu:17448; P08249; Q0QF44; Q8CF79; Q8R1P0 | Glycolysis and gluconeogenesis; TCA cycle | Mitochondrial protein degradation; Malate-aspartate shuttle; Citric acid cycle (TCA cycle) | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.946568086066385 | 0.795351011232032 | 0.379439362130093 | 0.0519452794981305 | 15464.3826212503 | 41218.8123977993 | 6349.06926840786 | 3539646.6249237 | 3439712.11067782 | 2814392.06783249 | 3214494.75039729 | 2177262.93413243 | 3118681.72885292 | 7068478.91480128 | 5414526.35847602 | 4605836.97916447 | 6275446.95884941 | 6149628.28208542 | 9656924.11001301 |
| P08121 | Collagen alpha-1(III) chain [OS=Mus musculus] | 695.631 | 63 | 61 | 1789 | 51 | 1464 | 138.9 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | extracellular matrix;other cell component | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 12825 | ENSMUSG00000026043 | Col3a1 | mmu:12825; P08121; Q61429; Q9CRN7 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Focal adhesion | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ECM proteoglycans; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; MET activates PTK2 signaling | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.00738207855214502 | 0.0413994480640273 | 0.394949139624895 | 0.976852696203657 | 619884.023482232 | 468692.52789102 | 275667.802679115 | 2.79020579584843E8 | 2.94236692581693E8 | 2.78582579285209E8 | 6.51340156000414E7 | 5.70632610319163E7 | 6.62894421161806E7 | 7.54516142044654E7 | 7.68700494785543E7 | 4.61499837269909E7 | 3.06665885804687E7 | 2.39448217703501E7 | 3.64849658219652E7 |
| P52927 | High mobility group protein HMGI-C [OS=Mus musculus] | 19.622 | 63 | 5 | 43 | 5 | 108 | 11.8 | cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | nucleus;other cell component | nucleic acid binding activity;other molecular function | 15364 | ENSMUSG00000056758 | Hmga2 | mmu:15364; P52927; Q3UQW0 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.779252881438118 | 0.56053198781818 | 0.336702291109547 | 0.130664835099106 | 319954.83032442 | 228777.540302378 | 227411.510007685 | 210264.647740795 | 238951.569339871 | 404743.063551681 | 993413.11105102 | 1070598.00165884 | 566537.703626656 | 681235.668365901 | 503102.248100656 | 826044.051259612 | ||||
| P17751 | Triosephosphate isomerase [OS=Mus musculus] | 49.057 | 63 | 12 | 145 | 12 | 249 | 26.7 | other metabolic processes | cytosol | other molecular function | 21991 | ENSMUSG00000023456 | Tpi1 | mmu:21991; P17751; Q3TJH2; Q3UC04; Q3UKG9; Q64513; Q9CVF9; Q9CWE7 | Fatty acid beta-oxidation; Glycolysis and gluconeogenesis | Gluconeogenesis; Glycolysis | 0.0806427656599262 | 0.0121257194234237 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.610019857175667 | 0.532399788858771 | 0.846117085258013 | 0.809503222445875 | 330816.658862061 | 509303.277190766 | 400581.208312955 | 2508200.21157107 | 1998539.96335636 | 2721175.10923974 | 2618512.04520777 | 1862714.96134193 | 2874979.35734375 | 9029946.93210895 | 6954894.5267767 | 6427613.76163295 | 3388942.90495023 | 3999204.03805736 | 4434675.15278015 |
| Cont_O46375 | Transthyretin OS=Bos taurus OX=9913 GN=TTR PE=1 SV=1 | 35.213 | 63 | 7 | 98 | 7 | 147 | 15.7 | other metabolic processes;signal transduction;other biological processes | non-structural extracellular | signal transduction activity or receptor binding;other molecular function | 280948 | ENSBTAG00000010991 | TTR | bta:280948; O46375; Q3SZ91 | Neutrophil degranulation; Retinoid metabolism and transport; The canonical retinoid cycle in rods (twilight vision) | 0.58171944587441 | 0.896787359697595 | 0.574380214123189 | 0.576573242661179 | 0.916283277860523 | 0.0154647678374212 | 0.313140733327643 | 0.338074799536125 | 9546693.56190286 | 1.31659005974371E7 | 8271040.97558915 | 1.0282617559534E7 | 8811959.22872725 | 1.34298684901053E7 | 2.33822192979533E7 | 2.03955874392209E7 | 1.95900458967146E7 | 1.51636766521962E7 | 1.10702472254716E7 | 9218071.15197036 | 9047123.1136248 | 9463495.33216257 | 1.05766898507312E7 | |
| Q99JI6 | Ras-related protein Rap-1b [OS=Mus musculus] | 34.031 | 63 | 9 | 84 | 9 | 184 | 20.8 | cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes | plasma membrane;other membranes;cytosol;other cell component | other molecular function | 215449 | ENSMUSG00000052681 | Rap1b | mmu:215449; Q99JI6 | Hepatocyte growth factor receptor signaling; Chemokine signaling pathway; Mapk signaling pathway; Na/K-ATPase/Src signaling; Integrin-mediated cell adhesion; Focal adhesion | Neutrophil degranulation; MAP2K and MAPK activation; Rap1 signalling; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; MET activates RAP1 and RAC1 | 0.615680953989958 | 0.845600701749816 | 0.579692877619887 | 0.703309497027447 | 0.813030657334935 | 0.983440558239231 | 0.50594120050135 | 0.812870015922388 | 10521.6032333623 | 20982.0939148299 | 1092792.61030233 | 1286954.41529451 | 1073121.26216853 | 685677.086956002 | 629242.737523905 | 828003.063254737 | 3931213.88716949 | 4067842.17788272 | 3944532.62829308 | 1482906.17334546 | 1080868.43495369 | 2268763.45821949 | |
| Cont_P00761 | Trypsin OS=Sus scrofa OX=9823 PE=1 SV=1 | 143.502 | 62 | 11 | 3859 | 10 | 231 | 24.4 | protein metabolism;other biological processes | non-structural extracellular | other molecular function | 0.254996071775817 | 0.172153475402034 | 0.357784551188889 | 0.34040294575649 | 0.822223648478518 | 0.740968241512781 | 0.960577895552113 | 0.148582186670595 | 5.17896971017178E9 | 5.13317471139103E9 | 7.27761160813741E9 | 2.70973552724487E9 | 1.73168232498425E9 | 2.0962236592694E9 | 3.08554430734093E9 | 3.85764460784296E9 | 3.06099934235171E9 | 1.42194297351806E9 | 1.8379662886425E9 | 3.81973460995747E9 | 5.23567407489624E9 | 5.3849654871275E9 | 2.81761370832162E9 | ||||||
| P14211 | Calreticulin [OS=Mus musculus] | 105.08 | 62 | 19 | 243 | 19 | 416 | 48 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;translational apparatus;nucleus;other cytoplasmic organelle;other cell component | signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function | 12317 | ENSMUSG00000003814 | Calr | mmu:12317; P14211; Q3TVD2 | Calcium regulation in cardiac cells | ER-Phagosome pathway; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Scavenging by Class A Receptors; Calnexin/calreticulin cycle | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.856884647332879 | 0.901056551888415 | 0.709416436039367 | 0.760027306440323 | 29010.1939176752 | 40438.9309766897 | 56470.2669367122 | 4146080.31907687 | 4788676.67235988 | 5620505.55686668 | 3731745.00016397 | 2573778.11690823 | 3727019.18482242 | 1.21431346024505E7 | 1.15652178398548E7 | 9027657.01145943 | 5278986.79529507 | 4694569.07998204 | 7831692.37354126 |
| Cont_Q3SZ57 | Alpha-fetoprotein OS=Bos taurus OX=9913 GN=AFP PE=2 SV=1 | 202.89 | 62 | 30 | 1153 | 29 | 610 | 68.5 | other metabolic processes;developmental processes;other biological processes | non-structural extracellular;other cell component | other molecular function | 506011 | ENSBTAG00000017131 | AFP | bta:506011; Q3SZ57 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 0.540832988168188 | 0.82964085881652 | 0.605387748357992 | 0.553772240900005 | 0.938859506774495 | 0.15729598575093 | 0.699570390946254 | 0.323545662226049 | 4.4629857016799E7 | 4.39639700572647E7 | 2.72178105183923E7 | 3.15168703669999E7 | 4.26075077823651E7 | 3.4328683389093E7 | 4.8541823037709E7 | 4.32960721364381E7 | 4.4115949306695E7 | 4.61564880446121E7 | 4.7548077639711E7 | 3.504265434565E7 | 2.7823391939759E7 | 3.01476017178829E7 | 5.24042356620578E7 | |
| Cont_P13645 | Keratin, type I cytoskeletal 10 OS=Homo sapiens OX=9606 GN=KRT10 PE=1 SV=6 | 286.713 | 62 | 30 | 1322 | 20 | 584 | 58.8 | cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes | plasma membrane;cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;other molecular function | 3858 | ENSG00000186395 | KRT10 | hsa:3858; P13645; Q14664; Q8N175 | Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.600890052902075 | 0.490821286240141 | 0.561934876627864 | 0.941696908693733 | 0.829734761131295 | 0.880940844456856 | 0.246231694954624 | 2.55433624902191E-5 | 8.57039306780817E7 | 1.2308209015436E8 | 1.23973335952419E8 | 1.09050331614224E8 | 1.30109606828786E8 | 1.02692161896587E8 | 8.73473050095944E7 | 1.23031831133367E8 | 7.19147674496861E7 | 1.29238189237995E8 | 9.43248217623685E7 | 1.03859326412487E8 | 5.11249836753994E8 | 2.4676744393623E8 | 2.01230291385254E8 | |
| P52480 | Pyruvate kinase PKM [OS=Mus musculus] | 163.393 | 62 | 27 | 442 | 27 | 531 | 57.8 | cell organization and biogenesis;other metabolic processes;other biological processes | cytosol;ER/Golgi;nucleus;other cell component | nucleic acid binding activity;kinase activity;other molecular function | 18746 | ENSMUSG00000032294 | Pkm | mmu:18746; P52480; Q3TBV8; Q3TBW5; Q3TC59; Q3U1X3; Q3U5P6; Q4VC20; Q64484; Q91YI8; Q9CWB1 | Glycolysis and gluconeogenesis; Purine metabolism | Neutrophil degranulation; Pyruvate metabolism; Glycolysis; Regulation of pyruvate metabolism | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.938859506774495 | 0.972868731003358 | 0.958705855138011 | 0.959522188921769 | 312569.127047718 | 79336.1029165598 | 280190.614862653 | 2.13357824001936E7 | 1.96436562290884E7 | 9081648.29120601 | 1.01259485831113E7 | 9467201.29798786 | 1.55257573035923E7 | 3.31547939620584E7 | 3.43565739025104E7 | 2.75852274417617E7 | 1.43901632993649E7 | 7722776.69094361 | 1.86748082798887E7 |
| P62908 | Small ribosomal subunit protein uS3 [OS=Mus musculus] | 44.876 | 61 | 14 | 146 | 14 | 243 | 26.7 | cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;translational apparatus;nucleus;other cell component | cytoskeletal activity;nucleic acid binding activity;other molecular function | 27050 | ENSMUSG00000030744 | Rps3 | mmu:27050; P17073; P47933; P62908 | Cytoplasmic ribosomal proteins | L13a-mediated translational silencing of Ceruloplasmin expression; SRP-dependent cotranslational protein targeting to membrane; Major pathway of rRNA processing in the nucleolus and cytosol; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition | 0.199859183640187 | 0.0204712693531403 | 1.50457038391225E-17 | 0.2282690138179 | 0.889322773294568 | 0.897374575947205 | 0.975873825035145 | 0.995207197530012 | 13392.2908067534 | 6664.84075995145 | 1396037.07035745 | 2096906.85456819 | 1354441.63195124 | 925606.130163894 | 926400.763318311 | 1496046.97044967 | 3684898.52106675 | 3802906.30171756 | 3176874.23464465 | 1308497.13417903 | 770444.702508235 | 1786633.97095349 | |
| P17742 | Peptidyl-prolyl cis-trans isomerase A [OS=Mus musculus] | 113.527 | 60 | 9 | 369 | 9 | 164 | 18 | cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes | non-structural extracellular;cytosol;nucleus;other cell component | signal transduction activity or receptor binding;other molecular function | 268373 | ENSMUSG00000071866 | Ppia | mmu:268373; P17742; Q9CWJ5; Q9R137 | Neutrophil degranulation; Basigin interactions | 0.100219677394751 | 0.099382125133403 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.946239447314336 | 0.696358249006924 | 0.937453377971347 | 0.331144967260478 | 1.16891341386391E7 | 754837.409863468 | 4157779.88062054 | 2.9189343463191E7 | 2.94929696895869E7 | 4.96473559496876E7 | 1.04342545713823E7 | 8178713.43858634 | 1.18234267071803E7 | 4.91534751033825E7 | 4.2865019365108E7 | 4.61937263356195E7 | 9682919.1999608 | 7275434.18699702 | 1.51319991253865E7 | |
| P20152 | Vimentin [OS=Mus musculus] | 183.446 | 60 | 29 | 762 | 27 | 466 | 53.7 | cell organization and biogenesis;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component | cytoskeletal activity;nucleic acid binding activity;other molecular function | 22352 | ENSMUSG00000026728 | Vim | mmu:22352; O08704; P20152; Q8CCH1 | Spinal cord injury; Primary focal segmental glomerulosclerosis (FSGS); Alpha 6 beta 4 integrin signaling pathway | Aggrephagy; Striated Muscle Contraction; Caspase-mediated cleavage of cytoskeletal proteins; RHOBTB1 GTPase cycle | 1.65082956259427E-17 | 0.0955146622024883 | 1.50457038391225E-17 | 0.137621774180062 | 0.873609880131656 | 0.0297998664849654 | 0.840672080806375 | 0.0332723373064956 | 573727.34417641 | 968981.536762911 | 1794707.43115169 | 4.14069582585024E7 | 3.33312643886138E7 | 2.54656192896882E7 | 6941733.99810384 | 6173483.46835617 | 8980531.63051753 | 8.80704815958352E7 | 8.07026224155391E7 | 5.51524218564722E7 | 1.5029979690535E7 | 6861556.37440952 | 1.68923991921504E7 |
| P48678 | Prelamin-A/C [OS=Mus musculus] | 202.607 | 60 | 37 | 529 | 36 | 665 | 74.2 | cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes | other membranes;cytoskeleton;nucleus;other cell component | other molecular function | 16905 | ENSMUSG00000028063 | Lmna | B3RH23; B3RH24; mmu:16905; P11516; P48678; P97859; Q3TIH0; Q3TTS8; Q3U733; Q3U7I5; Q3UCA0; Q3UCJ8; Q3UCU3; Q91WF2; Q9DC21 | Adipogenesis genes; FAS pathway and stress induction of HSP regulation | 1.65082956259427E-17 | 0.00670345592293191 | 0.139423967594304 | 1.70336894001643E-17 | 0.236076921565588 | 0.77212820363828 | 0.901149690306505 | 0.00692305873191716 | 56886.7483713492 | 69336.1384695612 | 100943.444664856 | 1.29312831685903E7 | 1.22006597313063E7 | 8045013.512583 | 3337288.2268023 | 3262868.75019265 | 5804803.63611667 | 6.75536277126862E7 | 5.59333072922179E7 | 3.75993669940438E7 | 7422846.33935557 | 4234323.21548912 | 7210898.93259597 | |
| P17182 | Alpha-enolase [OS=Mus musculus] | 126.804 | 60 | 19 | 244 | 16 | 434 | 47.1 | other metabolic processes;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;other cell component | nucleic acid binding activity;other molecular function | 13806; 433182 | ENSMUSG00000059040; ENSMUSG00000063524 | Eno1 | mmu:13806; mmu:433182; P17182; Q99KT7; Q9DCY7 | Glycolysis and gluconeogenesis | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.720832939248489 | 0.789540446904924 | 0.858218537342417 | 0.989544231571828 | 31098.019126098 | 70318.9502605952 | 40658.6319347469 | 1.28655809626545E7 | 1.34726279447959E7 | 7101469.5445256 | 9089751.86845938 | 7552189.93174957 | 1.17772011823713E7 | 3.50544676757808E7 | 2.99447661492486E7 | 2.18255690502528E7 | 1.30151947674988E7 | 1.11532480577619E7 | 1.75489228796712E7 | |
| Q9CQV8 | 14-3-3 protein beta/alpha [OS=Mus musculus] | 64.301 | 59 | 13 | 263 | 6 | 246 | 28.1 | other biological processes | cytosol;nucleus;other cell component | enzyme regulator activity;other molecular function | 54401 | ENSMUSG00000018326 | Ywhab | mmu:54401; O70455; Q3TY33; Q3UAN6; Q9CQV8 | IL-3 signaling pathway; Myometrial relaxation and contraction pathways; Alpha 6 beta 4 integrin signaling pathway; Calcium regulation in cardiac cells; EGFR1 signaling pathway | RAF activation; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; MAP2K and MAPK activation; Negative regulation of MAPK pathway; Rap1 signalling; TP53 Regulates Metabolic Genes; mTORC1-mediated signalling; Activation of BAD and translocation to mitochondria ; RHO GTPases activate PKNs; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Regulation of localization of FOXO transcription factors; Frs2-mediated activation; Signaling by Hippo | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.349255191559715 | 0.764791307960872 | 0.937453377971347 | 0.506626554334227 | 827509.480689047 | 665625.54503926 | 484962.959916708 | 352602.166539251 | 290574.29293556 | 554603.529270735 | 3354582.04090562 | 2429479.578985 | 1791950.60044087 | 552088.916805761 | 620253.16794601 | 851553.2990227 | |||
| P11276 | Fibronectin [OS=Mus musculus] | 867.353 | 58 | 95 | 2246 | 59 | 2477 | 272.4 | cell adhesion;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi | signal transduction activity or receptor binding;enzyme regulator activity;other molecular function | 14268 | ENSMUSG00000026193 | Fn1 | G5E8B8; mmu:14268; P11276; Q61567; Q61568; Q61569; Q64233; Q80UI4 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Inflammatory response pathway; Regulation of actin cytoskeleton; Comprehensive IL-17A signaling; Focal adhesion | ECM proteoglycans; Platelet degranulation ; Cell surface interactions at the vascular wall; Syndecan interactions; MAP2K and MAPK activation; Integrin cell surface interactions; Molecules associated with elastic fibres; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Fibronectin matrix formation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; Degradation of the extracellular matrix; Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells; MET activates PTK2 signaling; GPER1 signaling | 0.0844744457809114 | 0.00584906503121538 | 1.50457038391225E-17 | 0.156115961659409 | 0.974036928885484 | 0.564710097967506 | 0.435823028559966 | 0.896613838854506 | 3.10111960161575E7 | 2.79853612635427E7 | 2.39278028537136E7 | 2.27076161669542E8 | 2.29530848002383E8 | 1.81481696567249E8 | 2.13523563015262E8 | 1.92386583493888E8 | 2.00792310651879E8 | 3.0604731494329E8 | 2.72875123758133E8 | 2.45952285820886E8 | 1.1928889459527E8 | 1.00071254189999E8 | 1.59531432686856E8 |
| P57780 | Alpha-actinin-4 [OS=Mus musculus] | 239.42 | 58 | 45 | 483 | 30 | 912 | 104.9 | cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes | cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 60595 | ENSMUSG00000054808 | Actn4 | mmu:60595; P57780 | Primary focal segmental glomerulosclerosis (FSGS) | Platelet degranulation | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 0.19149089837131 | 0.921882153462399 | 0.795351011232032 | 0.968364585136618 | 0.938282411159324 | 5221.79731213346 | 36578.541519335 | 9107610.67207618 | 1.00453975465233E7 | 1.03378326393571E7 | 5095419.11923033 | 3409382.50707632 | 5238186.41277381 | 1.31020350186557E7 | 1.2711162036506E7 | 9162046.18669404 | 4501757.36231035 | 3002316.05426355 | 5816939.08777499 | |
| Cont_P02533 | Keratin, type I cytoskeletal 14 OS=Homo sapiens OX=9606 GN=KRT14 PE=1 SV=4 | 164.831 | 58 | 26 | 684 | 9 | 472 | 51.5 | cell organization and biogenesis;other biological processes | plasma membrane;cytosol;cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 3861 | ENSG00000186847 | KRT14 | hsa:3861; P02533; Q14715; Q53XY3; Q9BUE3; Q9UBN2; Q9UBN3; Q9UCY4 | Corticotropin-releasing hormone signaling | Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin; Developmental Lineage of Mammary Gland Myoepithelial Cells; Type I hemidesmosome assembly | 0.821333803243143 | 0.880930298968675 | 0.666244110962191 | 0.887279041944908 | 0.735573385767802 | 0.728871118050286 | 0.645534074006669 | 1.76226512549596E-4 | 6033554.14310828 | 6671959.15781397 | 7782964.06135275 | 8837829.92566611 | 1.15627425945257E7 | 9278023.72116937 | 1.41062299354562E7 | 8950994.20838312 | 7841743.81261716 | 1.15454726530467E7 | 7260451.91646668 | 9574113.2223773 | 5.39893889957522E7 | 2.05703168301172E7 | 1.34402077310531E7 |
| P51150 | Ras-related protein Rab-7a [OS=Mus musculus] | 37.713 | 58 | 10 | 86 | 10 | 207 | 23.5 | cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes | other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component | other molecular function | 19349 | ENSMUSG00000079477 | Rab7a | mmu:19349; P51150 | Neutrophil degranulation; TBC/RABGAPs; RAB geranylgeranylation; MHC class II antigen presentation; RAB GEFs exchange GTP for GDP on RABs; RAC1 GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; RHOH GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOF GTPase cycle; RHOD GTPase cycle | 0.636939170495467 | 0.655487072215252 | 0.329609069656752 | 0.341991892565807 | 0.833071794079159 | 0.98558531112136 | 0.651065339556331 | 0.988640647886026 | 42971.6509871291 | 5091.39156563082 | 639760.02594531 | 739162.65348356 | 500483.334399648 | 222359.681018454 | 184373.14165851 | 370823.666713167 | 1735951.05761641 | 1620414.31808119 | 1328466.83726779 | 643161.73478289 | 519980.624428654 | 811733.26317896 | ||
| P61982 | 14-3-3 protein gamma [OS=Mus musculus] | 60.158 | 58 | 13 | 257 | 7 | 247 | 28.3 | stress response;other biological processes | cytosol;mitochondrion;nucleus;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;other molecular function | 22628 | ENSMUSG00000051391 | Ywhag | mmu:22628; O70457; P35214; P61982; Q3UFD6; Q4FK44; Q9UDP2; Q9UN99 | Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells | Regulation of PLK1 Activity at G2/M Transition; Anchoring of the basal body to the plasma membrane; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; AURKA Activation by TPX2; TP53 Regulates Metabolic Genes; Activation of BAD and translocation to mitochondria ; RHO GTPases activate PKNs; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Regulation of localization of FOXO transcription factors | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.916283277860523 | 0.962211568833812 | 0.977491813528386 | 0.819844267712751 | 11156.8721315139 | 36200.581767039 | 23387.4360494223 | 4210658.69388125 | 3208586.17889202 | 3661156.3629375 | 2204630.70190343 | 1697092.38093418 | 2907466.79306312 | 1.01883087621914E7 | 7383913.05140651 | 5871207.54485329 | 2178767.01595034 | 2340848.33881766 | 2680750.92991385 |
| Cont_P15497 | Apolipoprotein A-I OS=Bos taurus OX=9913 GN=APOA1 PE=1 SV=3 | 75.831 | 58 | 15 | 290 | 15 | 265 | 30.3 | cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes | non-structural extracellular | transporter activity;enzyme regulator activity;other molecular function | 281631 | APOA1 | A5D7M9; bta:281631; P15497; Q3SZD9 | Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Chylomicron assembly; Chylomicron remodeling; HDL remodeling; Retinoid metabolism and transport; HDL clearance; HDL assembly; Heme signaling; Scavenging by Class B Receptors | 0.65780924735352 | 0.31171894348249 | 0.726427194598544 | 0.535702081245677 | 0.946568086066385 | 0.941920360687835 | 0.809490543293719 | 0.822877979404198 | 2.21263225838005E7 | 1.78450644532212E7 | 1.97796498018408E7 | 1.78787447784222E7 | 2.53238412660337E7 | 2.49900782473361E7 | 1.22627903702188E7 | 1.43058080986995E7 | 1.29755953410419E7 | 2.9020982567081E7 | 2.93612230403275E7 | 2.70148520622022E7 | 1.43730714643769E7 | 1.13015329009906E7 | 2.71801121001229E7 | ||
| P0DP27 | Calmodulin-2 [OS=Mus musculus] | 62.362 | 57 | 9 | 169 | 9 | 149 | 16.8 | cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cell component | signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function | 12314; 12315 | ENSMUSG00000001175; ENSMUSG00000019370; ENSMUSG00000036438 | Calm2 | mmu:12313; mmu:12314; mmu:12315; P02593; P0DP27; P62204; P70667; P99014; Q3TEH7; Q3THK5; Q3U6Z5; Q3U7C7; Q498A3; Q61379; Q61380; Q8BNC9; Q91VQ9; Q9D6G4 | Alzheimer's disease; Glycogen metabolism; Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.984287101108728 | 0.776236845683195 | 0.735963266366428 | 0.938345185723697 | 9269.40267105667 | 18119.1865278059 | 4478912.44611262 | 4086961.29294744 | 4541929.19146932 | 1934024.88060433 | 1698621.68217392 | 2127186.45800379 | 6815126.06503849 | 7660172.12932354 | 6531268.56798019 | 3730259.02064885 | 2678903.48416191 | 4079256.80015976 | ||
| P07356 | Annexin A2 [OS=Mus musculus] | 93.779 | 57 | 19 | 258 | 19 | 339 | 38.7 | cell adhesion;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component | enzyme regulator activity;cytoskeletal activity;other molecular function | 12306 | ENSMUSG00000032231 | Anxa2 | mmu:12306; P07356 | Prostaglandin synthesis and regulation | Neutrophil degranulation; Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells; Dissolution of Fibrin Clot | 1.65082956259427E-17 | 0.0270399871803413 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.709229396391097 | 0.79692396389698 | 0.261357540418382 | 0.992207061422946 | 80913.0723608937 | 91932.8000229824 | 159834.257411985 | 8809993.14550338 | 1.20868855954933E7 | 1.24351534037538E7 | 5139070.9377241 | 4323306.53315277 | 5989807.68314801 | 3.18682696567451E7 | 3.28596309408812E7 | 2.58712263649755E7 | 1.49101863447254E7 | 1.21319314583051E7 | 1.7708905346053E7 |
| P35700 | Peroxiredoxin-1 [OS=Mus musculus] | 37.928 | 57 | 10 | 157 | 8 | 199 | 22.2 | cell cycle OR cell proliferation;other metabolic processes;stress response;signal transduction;other biological processes | cytosol;nucleus;other cell component | other molecular function | 18477 | ENSMUSG00000028691 | Prdx1 | mmu:18477; P35700; Q3UBV4; Q9CWI2 | Oxidative stress and redox pathway | TP53 Regulates Metabolic Genes; Detoxification of Reactive Oxygen Species; NFE2L2 regulating anti-oxidant/detoxification enzymes | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.971110042775673 | 0.696358249006924 | 0.609490560578387 | 0.971151633247904 | 28013.3390039087 | 10513.3151242123 | 6837119.7949797 | 6183018.26261091 | 3863278.95114693 | 4753006.47365099 | 4035477.11586219 | 6451102.62207213 | 8386206.05847774 | 8171820.06897361 | 5665108.45486536 | 3203316.06079976 | 2771774.56679962 | 3952127.57034216 | |
| P09411 | Phosphoglycerate kinase 1 [OS=Mus musculus] | 116.462 | 57 | 18 | 287 | 18 | 417 | 44.5 | protein metabolism;other metabolic processes;stress response;other biological processes | non-structural extracellular;other membranes;cytosol;mitochondrion;other cell component | kinase activity;other molecular function | 18655 | ENSMUSG00000062070 | Pgk1 | mmu:18655; P09411; Q3TPE6; Q3UKV8; Q5XJE7 | Glycolysis and gluconeogenesis | Gluconeogenesis; Glycolysis | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.465126095372736 | 0.766862952867809 | 0.820281310709571 | 0.891044455497809 | 78089.4641074341 | 38741.0917691314 | 23421.0514741904 | 4316274.39280249 | 5023293.68471847 | 1442874.888393 | 2829873.33459098 | 2934698.045784 | 3868274.47312523 | 1.65254946701665E7 | 1.56270051770472E7 | 1.22346365889796E7 | 4530199.20599689 | 2315853.03926933 | 6654180.61411261 |
| P33434 | 72 kDa type IV collagenase [OS=Mus musculus] | 212.03 | 56 | 30 | 889 | 30 | 662 | 74.1 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes | extracellular matrix;plasma membrane;other membranes;cytoskeleton;mitochondrion;nucleus;other cell component | other molecular function | 17390 | ENSMUSG00000031740 | Mmp2 | mmu:17390; P33434 | Lung fibrosis; IL-3 signaling pathway; Matrix metalloproteinases | Collagen degradation; Extra-nuclear estrogen signaling; EPH-ephrin mediated repulsion of cells; Activation of Matrix Metalloproteinases | 0.372996577396536 | 0.964209443670126 | 0.342075680986172 | 0.708142491896103 | 0.993994198406889 | 0.459747209584207 | 0.34519376377552 | 0.809503222445875 | 1.45817945044039E7 | 3.99854546791863E7 | 2.31586213408419E7 | 6.16168347215595E7 | 6.71128653428481E7 | 5.47627512450794E7 | 2.153095933586E7 | 2.04088973517033E7 | 2.1514079157928E7 | 9.59427020238632E7 | 8.49468673692442E7 | 8.11217362792938E7 | 5.65046943814106E7 | 3.5725700482165E7 | 6.85636819548367E7 |
| P26645 | Myristoylated alanine-rich C-kinase substrate [OS=Mus musculus] | 102.649 | 56 | 9 | 183 | 9 | 309 | 29.6 | cell organization and biogenesis;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component | cytoskeletal activity;other molecular function | 17118 | ENSMUSG00000069662 | Marcks | mmu:17118; P26645 | Acetylcholine regulates insulin secretion | 0.686762258673 | 0.868732914228523 | 0.429932681715422 | 0.675450317413542 | 0.854305439376382 | 0.86315143463057 | 0.557354230551857 | 0.960067393782086 | 42980.3388156882 | 41898.6161386359 | 41525.7349435975 | 1443906.20707304 | 1714465.16128686 | 1542596.23448158 | 536168.318695651 | 523262.393588195 | 852705.514569508 | 4438527.05710504 | 4375638.80151598 | 3114301.65618414 | 1532659.00136844 | 1122453.03544494 | 1644505.61194952 | |
| P29391 | Ferritin light chain 1 [OS=Mus musculus] | 41.989 | 56 | 7 | 45 | 7 | 183 | 20.8 | transport;other biological processes | non-structural extracellular;other cytoplasmic organelle;other cell component | other molecular function | Ftl1 | P29391; Q8WUQ8 | 0.470628233842304 | 0.916949047389333 | 0.436404735539909 | 0.838430822182208 | 0.984023681099692 | 0.594847259878045 | 0.840672080806375 | 0.286865690112685 | 11250.950061026 | 164363.787033117 | 96571.5430931945 | 117093.264494885 | 43219.3148133758 | 41008.0784847386 | 49942.1149094357 | 231062.388635405 | 217800.809192591 | 248463.651274961 | 22056.2158795235 | ||||||||
| Q00915 | Retinol-binding protein 1 [OS=Mus musculus] | 48.013 | 56 | 7 | 112 | 7 | 135 | 15.8 | other metabolic processes;other biological processes | cytosol;nucleus;other cell component | other molecular function | 19659 | ENSMUSG00000046402 | Rbp1 | mmu:19659; Q00915 | Retinol metabolism | Retinoid metabolism and transport; The canonical retinoid cycle in rods (twilight vision) | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.762176653003896 | 0.764791307960872 | 0.850760367544917 | 0.474848317785811 | 1866015.44814727 | 1690749.75742334 | 1346043.60114138 | 600896.849096756 | 543423.979559132 | 1233445.01773539 | 4815413.61167082 | 4593886.64533296 | 3422364.46967646 | 894694.26199539 | 744604.388112891 | 1536347.73518956 | |||
| P27773 | Protein disulfide-isomerase A3 [OS=Mus musculus] | 115.891 | 55 | 23 | 291 | 23 | 505 | 56.6 | cell adhesion;cell organization and biogenesis;stress response;signal transduction;other biological processes | non-structural extracellular;other membranes;ER/Golgi;other cell component | nucleic acid binding activity;other molecular function | 14827 | ENSMUSG00000027248 | Pdia3 | mmu:14827; P27773; Q3TEI9; Q3TIL2; Q3UZK8; Q8C2F4; Q99LF6 | ER-Phagosome pathway; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Calnexin/calreticulin cycle | 0.9135584231482 | 0.736536116100563 | 0.498293621965442 | 0.874168055361729 | 0.850917681937748 | 0.862063111456553 | 0.881496352314601 | 0.939046770372612 | 206281.038958907 | 253939.7116523 | 128510.108086966 | 6669793.66068216 | 7133803.24141356 | 5637352.69437344 | 5319375.96186612 | 3844376.07822282 | 6321729.00885173 | 1.83298906806341E7 | 1.50101054148645E7 | 1.26051366299531E7 | 6670485.36185494 | 6059857.55300524 | 8984695.03809976 | |
| Cont_Q3MHN5 | Vitamin D-binding protein OS=Bos taurus OX=9913 GN=GC PE=2 SV=1 | 113.599 | 55 | 20 | 319 | 20 | 474 | 53.3 | other metabolic processes;transport | non-structural extracellular;other cell component | transporter activity;cytoskeletal activity;other molecular function | 530076 | GC | bta:530076; Q3MHN5 | 0.549057967251154 | 0.804331105646976 | 0.579435037816218 | 0.479472599858427 | 0.946173787415917 | 0.139718417146003 | 0.570795727084329 | 0.421365656927814 | 1.55879441314789E7 | 1.53074066841615E7 | 7458694.29508707 | 1.04365108192777E7 | 1.20620475306269E7 | 8309099.82300618 | 1.67215053413279E7 | 1.54231806136738E7 | 1.57780518794517E7 | 1.6556516146824E7 | 1.52311500265876E7 | 1.20681229464E7 | 8133055.93664235 | 9478628.98672491 | 1.47438110125204E7 | |||
| P31786 | Acyl-CoA-binding protein [OS=Mus musculus] | 14.554 | 55 | 3 | 25 | 3 | 87 | 10 | other metabolic processes;stress response;developmental processes;other biological processes | non-structural extracellular;ER/Golgi | other molecular function | 13167 | ENSMUSG00000026385 | Dbi | mmu:13167; P31786 | PPAR signaling pathway | Mitochondrial Fatty Acid Beta-Oxidation | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.927458364365403 | 0.815208287206116 | 0.570795727084329 | 0.579328739210792 | 307456.870510134 | 372967.502828048 | 466246.230022766 | 205366.44219537 | 138939.514670588 | 212068.293185609 | 460651.499495821 | 517145.077763924 | 572958.93647871 | 99167.9909364818 | 109813.402160245 | 130980.248883021 | |||
| O08709 | Peroxiredoxin-6 [OS=Mus musculus] | 58.137 | 55 | 11 | 118 | 11 | 224 | 24.9 | cell organization and biogenesis;other metabolic processes;stress response;other biological processes | cytosol;other cytoplasmic organelle | other molecular function | 11758 | Prdx6 | mmu:11758; O08709; Q91WT2; Q9QWP4; Q9QWW0 | Neutrophil degranulation; Detoxification of Reactive Oxygen Species | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.912218866069753 | 0.98558531112136 | 0.866315173576397 | 0.958852965333904 | 1634804.34803319 | 1706671.96318366 | 462379.005285331 | 814979.975671148 | 650045.663219344 | 990585.013572245 | 3486272.66785309 | 3240204.32262637 | 2629774.04644166 | 1287444.576733 | 356862.065430393 | 1648957.81286328 | |||||
| Q61598 | Rab GDP dissociation inhibitor beta [OS=Mus musculus] | 90.105 | 55 | 19 | 207 | 15 | 445 | 50.5 | transport;signal transduction;other biological processes | other membranes;ER/Golgi;other cell component | enzyme regulator activity;other molecular function | 14569 | ENSMUSG00000021218 | Gdi2 | mmu:14569; Q541Z9; Q61598; Q8C530; Q9D8M9 | Neutrophil degranulation; RAB GEFs exchange GTP for GDP on RABs | 1.65082956259427E-17 | 0.0445586736872124 | 1.50457038391225E-17 | 0.12230616593894 | 0.957324015670425 | 0.696358249006924 | 0.947056398526689 | 0.891044455497809 | 7568.30103587639 | 2613166.41142051 | 2980669.16495025 | 3507823.89455971 | 1018070.34575623 | 727946.612092406 | 1353313.10952308 | 4351511.80036085 | 4094060.40698043 | 4061464.64033076 | 1257652.94808244 | 945188.523481553 | 1812216.8966664 | |||
| O09131 | Glutathione S-transferase omega-1 [OS=Mus musculus] | 32.337 | 55 | 12 | 134 | 12 | 240 | 27.5 | other metabolic processes;signal transduction;other biological processes | cytosol;other cell component | other molecular function | 14873 | ENSMUSG00000025068 | Gsto1 | mmu:14873; O09131; Q3TH87 | Metapathway biotransformation; Myometrial relaxation and contraction pathways; Oxidative stress and redox pathway | Glutathione conjugation; Methylation; Vitamin C (ascorbate) metabolism | 0.828088839920889 | 0.868732914228523 | 0.827536988704287 | 0.921569528792101 | 0.829930391195847 | 0.972868731003358 | 0.850760367544917 | 0.91523518908434 | 1.16523031330507E7 | 4485678.96181783 | 5228918.91172617 | 7429111.17402723 | 5364569.45791218 | 6154543.21131111 | 3951080.24175672 | 3499039.00524432 | 4879673.6485662 | 5704724.74672471 | 5308450.19876887 | 5090643.61787655 | 6211709.08335403 | 3610503.83521333 | 3381654.01076559 |
| P35979 | Large ribosomal subunit protein uL11 [OS=Mus musculus] | 29.639 | 55 | 6 | 64 | 6 | 165 | 17.8 | protein metabolism;other metabolic processes | cytosol;translational apparatus;nucleus;other cell component | nucleic acid binding activity;other molecular function | 269261 | ENSMUSG00000038900 | Rpl12 | mmu:269261; P35979; Q9CQK4 | Cytoplasmic ribosomal proteins; mRNA processing | L13a-mediated translational silencing of Ceruloplasmin expression; SRP-dependent cotranslational protein targeting to membrane; Major pathway of rRNA processing in the nucleolus and cytosol; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 1.65082956259427E-17 | 0.012106576537997 | 1.50457038391225E-17 | 0.113740476677079 | 0.990459928977729 | 0.904392641853656 | 0.968364585136618 | 0.859280013525435 | 13586.9255483391 | 723027.615040525 | 816717.155861558 | 427127.222666935 | 340773.547868048 | 360118.474082686 | 535619.345441155 | 1082129.54307879 | 1209755.68190013 | 1070036.12405551 | 389436.649395538 | 304672.729853011 | 588482.35090214 | ||
| Q61599 | Rho GDP-dissociation inhibitor 2 [OS=Mus musculus] | 30.236 | 55 | 7 | 55 | 7 | 200 | 22.8 | signal transduction;other biological processes | cytosol | enzyme regulator activity;other molecular function | 11857 | ENSMUSG00000030220 | Arhgdib | mmu:11857; Q3TEB3; Q61599 | G13 signaling pathway; FAS pathway and stress induction of HSP regulation | RAC1 GTPase cycle; RAC3 GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RHOG GTPase cycle; RHOH GTPase cycle | 0.896523374675327 | 0.964709887217926 | 0.730324052254867 | 0.890289034593217 | 0.944154202827561 | 0.821250089830506 | 0.92723844956096 | 0.0935491991990551 | 32474.5706791495 | 14325.7245980277 | 440880.074294265 | 319533.924051821 | 554500.105293745 | 101227.692210764 | 79857.2367890125 | 180726.341626593 | 999410.084626213 | 533736.514746238 | 860743.749144492 | 85660.7954451718 | 51909.6934486661 | 122196.080730475 | |
| Q6IRU2 | Tropomyosin alpha-4 chain [OS=Mus musculus] | 57.649 | 54 | 14 | 181 | 13 | 248 | 28.5 | other biological processes | cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 326618 | ENSMUSG00000031799 | Tpm4 | mmu:326618; Q6IRU2 | Striated Muscle Contraction; RHOV GTPase cycle; Smooth Muscle Contraction | 1.65082956259427E-17 | 0.0604891281086189 | 1.50457038391225E-17 | 0.277029822654878 | 0.950643439691574 | 0.475270298946442 | 0.995103281526289 | 0.769722729696518 | 48169.0765970921 | 91422.0645346332 | 101278.05213091 | 7976648.59092772 | 8281478.09635796 | 7637503.87327968 | 2730566.6024022 | 1705684.35053161 | 4078690.74622792 | 1.16856488939063E7 | 1.14353238001446E7 | 8644589.28738447 | 3435042.86921096 | 1968023.76809684 | 4478416.48668098 | |
| P47931 | Follistatin [OS=Mus musculus] | 72.636 | 54 | 13 | 179 | 13 | 344 | 37.8 | cell cycle OR cell proliferation;developmental processes;signal transduction;other biological processes | nucleus;other cell component | signal transduction activity or receptor binding;other molecular function | 14313 | ENSMUSG00000021765 | Fst | A6H6P0; mmu:14313; P47931 | TGF-beta signaling pathway | Antagonism of Activin by Follistatin | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.912218866069753 | 0.950675859937599 | 0.679036846514028 | 0.849720620922415 | 7272167.90433319 | 7396919.94462099 | 6499969.62532323 | 4381221.5370214 | 4385282.70515593 | 5249526.88162253 | 8741151.05479083 | 8226871.39816201 | 5331222.84220915 | 2367848.30342728 | 715525.145319083 | 3901425.58057529 | |||
| Cont_P08779 | Keratin, type I cytoskeletal 16 OS=Homo sapiens OX=9606 GN=KRT16 PE=1 SV=4 | 140.751 | 54 | 25 | 569 | 12 | 473 | 51.2 | cell organization and biogenesis;stress response;other biological processes | plasma membrane;cytosol;cytoskeleton | cytoskeletal activity | 3868 | ENSG00000186832 | KRT16 | A8K488; hsa:3868; P08779; P30654; Q16402; Q9UBG8 | Vitamin D receptor pathway | Formation of the cornified envelope | 0.941324060398065 | 0.961351301268194 | 0.761460393544015 | 0.887279041944908 | 0.82543231800733 | 0.493923182294169 | 0.895302208460818 | 3.1065941501805E-4 | 1047544.82178002 | 1389728.97312405 | 1389730.63830375 | 1501449.09449526 | 2307427.01338473 | 2939547.44501319 | 7196685.12946156 | 1715910.61220057 | 2812173.28112121 | 4331979.12309994 | 1639569.64130669 | 1737373.70058763 | 9547147.41410007 | 4434008.92515372 | 2223613.02167429 |
| P47879 | Insulin-like growth factor-binding protein 4 [OS=Mus musculus] | 76.974 | 54 | 10 | 179 | 10 | 254 | 27.8 | cell cycle OR cell proliferation;signal transduction;other biological processes | non-structural extracellular | other molecular function | 16010 | ENSMUSG00000017493 | Igfbp4 | mmu:16010; O35666; P47879; Q3TMV0 | Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Myometrial relaxation and contraction pathways | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.194454617400155 | 0.797858239267722 | 0.384825651287801 | 0.925251017275216 | 598012.753056151 | 220890.166133709 | 808955.893414319 | 2.42668746185362E7 | 2.35661091910725E7 | 2.20103948370773E7 | 1.1489486634584E7 | 9395826.54401368 | 1.03414425178759E7 | 1.20544350527508E7 | 1.17426221200254E7 | 7571405.70789237 | 6120402.0499282 | 3657692.98865192 | 6280545.41029435 |
| P62897 | Cytochrome c, somatic [OS=Mus musculus] | 17.03 | 54 | 5 | 32 | 5 | 105 | 11.6 | other metabolic processes;signal transduction;other biological processes | cytosol;mitochondrion | other molecular function | 13063 | ENSMUSG00000058927; ENSMUSG00000063694 | Cycs | mmu:13063; P00009; P62897; Q8C2S2 | Oxidative damage response; p53 signaling; Parkinson's disease; Na/K-ATPase/Src signaling | TP53 Regulates Metabolic Genes; Respiratory electron transport; Cytoprotection by HMOX1; Detoxification of Reactive Oxygen Species; Release of apoptotic factors from the mitochondria; Pyroptosis; Activation of caspases through apoptosome-mediated cleavage; Regulation of the apoptosome activity; Transcriptional activation of mitochondrial biogenesis | 0.287918277254699 | 0.664079299483355 | 0.253564158652808 | 0.997751268638055 | 0.976873891151678 | 0.35166285974068 | 0.896866816139962 | 0.809503222445875 | 21078.0178036204 | 353781.78703588 | 469413.121746567 | 589668.591665022 | 164224.978576512 | 120926.022521668 | 153753.14547937 | 944247.135809769 | 845121.491133909 | 677710.338370425 | 158862.252050871 | 200320.300269668 | 301133.028713877 | ||
| Q7TPR4 | Alpha-actinin-1 [OS=Mus musculus] | 235.529 | 54 | 42 | 511 | 27 | 892 | 103 | cell adhesion;cell organization and biogenesis;other biological processes | plasma membrane;other membranes;cytoskeleton;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function | 109711 | ENSMUSG00000015143 | Actn1 | mmu:109711; Q7TPR4 | Regulation of actin cytoskeleton; Integrin-mediated cell adhesion; Focal adhesion | Platelet degranulation ; RHOF GTPase cycle; RHOBTB2 GTPase cycle; RHOD GTPase cycle; Regulation of cytoskeletal remodeling and cell spreading by IPP complex components | 0.995554138371554 | 0.178726136005694 | 0.819280225722906 | 0.941696908693733 | 0.974207409660283 | 0.744084716394381 | 0.837231569641376 | 0.879972045955715 | 354073.059499792 | 209249.076355465 | 897084.460899514 | 5526121.35104279 | 6211867.70337129 | 6893436.45630869 | 2413615.48536692 | 1933168.81934458 | 3229981.90899851 | 1.03807818109957E7 | 1.11771340173328E7 | 8282960.99949337 | 3416305.89125481 | 2797115.44078374 | 4939050.64701654 |
| Q9Z1Q5 | Chloride intracellular channel protein 1 [OS=Mus musculus] | 42.206 | 54 | 9 | 74 | 9 | 241 | 27 | transport;other biological processes | non-structural extracellular;plasma membrane;other membranes;mitochondrion;ER/Golgi;nucleus;other cell component | transporter activity;other molecular function | 114584 | ENSMUSG00000007041 | Clic1 | mmu:114584; Q9Z1Q5 | 0.469735153113543 | 0.665461902659705 | 0.393759312397256 | 0.647634649567584 | 0.873755746039336 | 0.45138210203261 | 0.421486031099999 | 0.769722729696518 | 21384.3285028392 | 18098.1480760882 | 282403.300686972 | 366245.338629701 | 327890.510802669 | 34676.5047667658 | 84831.4301508928 | 117692.733558477 | 782105.773253663 | 757861.516675744 | 756470.259317965 | 347753.783372261 | 142577.816442464 | 282666.053269447 | |||
| P68372 | Tubulin beta-4B chain [OS=Mus musculus] | 85.867 | 53 | 17 | 253 | 3 | 445 | 49.8 | cell organization and biogenesis;other biological processes | cytoskeleton;other cell component | cytoskeletal activity;nucleic acid binding activity;other molecular function | 227613 | ENSMUSG00000036752 | Tubb4b | mmu:227613; P05217; P68372; Q3TKF0; Q3UJ73; Q99JZ6 | Neutrophil degranulation; PKR-mediated signaling; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-independent Golgi-to-ER retrograde traffic; Hedgehog 'off' state; MHC class II antigen presentation; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; COPI-mediated anterograde transport; Separation of Sister Chromatids; Anchoring of the basal body to the plasma membrane; Resolution of Sister Chromatid Cohesion; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; RHO GTPases Activate Formins; AURKA Activation by TPX2; EML4 and NUDC in mitotic spindle formation; Intraflagellar transport; Carboxyterminal post-translational modifications of tubulin; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Recycling pathway of L1; RHO GTPases activate IQGAPs; The role of GTSE1 in G2/M progression after G2 checkpoint; Aggrephagy; Sealing of the nuclear envelope (NE) by ESCRT-III | 0.205801242418232 | 0.82964085881652 | 1.50457038391225E-17 | 0.126912128965224 | 0.898895014125291 | 0.915464852681021 | 0.709593139419252 | 0.953305976192702 | 2510.01980218531 | 3275114.04938016 | 2598821.51327027 | 1906519.60409322 | 1355554.11820818 | 1376215.81385627 | 1605138.68109294 | 6571183.44879001 | 5839187.09328728 | 4547155.57257512 | 2936550.69049437 | 1355995.13732086 | 2695608.39525063 | |||
| P57776 | Elongation factor 1-delta [OS=Mus musculus] | 62.183 | 53 | 12 | 114 | 11 | 281 | 31.3 | protein metabolism;other metabolic processes | nucleus;other cell component | nucleic acid binding activity;other molecular function | 66656 | Eef1d | mmu:66656; P57776; Q68FG5; Q9CWW2; Q9CWY1; Q9CYD4; Q9CYJ5 | Translation factors | Eukaryotic Translation Elongation | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.955415831169955 | 0.815208287206116 | 0.910644219048229 | 0.172162260281775 | 1660276.54796983 | 2618710.91323531 | 1110665.01652067 | 722609.995998999 | 708945.375547943 | 938859.400412804 | 4534487.91462717 | 3664812.25870665 | 3428916.91100971 | 700669.503793328 | 402637.691071844 | 977022.437052094 | ||||
| P63017 | Heat shock cognate 71 kDa protein [OS=Mus musculus] | 161.557 | 53 | 28 | 572 | 23 | 646 | 70.8 | cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component | signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function | 15481 | ENSMUSG00000015656 | Hspa8 | mmu:15481; P08109; P12225; P63017; Q3U6R0; Q3U764; Q3U7D7; Q3U7E2; Q3U9B4; Q3U9G0; Q3UGM0; Q5FWJ6; Q62373; Q62374; Q62375; Q6NZD0 | Mapk signaling pathway; Exercise-induced circadian regulation | Neutrophil degranulation; mRNA Splicing - Major Pathway; Regulation of HSF1-mediated heat shock response; PKR-mediated signaling; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis; Attenuation phase; Lysosome Vesicle Biogenesis; GABA synthesis, release, reuptake and degradation; AUF1 (hnRNP D0) binds and destabilizes mRNA; Protein methylation | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.987939278265184 | 0.953011140807089 | 0.709593139419252 | 0.587315224195015 | 247063.168316828 | 221267.865667273 | 228333.997143376 | 2.34302361722569E7 | 1.91610816116977E7 | 2.44529780700925E7 | 1.52458610795295E7 | 1.21057626921531E7 | 1.98188188374949E7 | 4.35786305197153E7 | 3.523488629513E7 | 2.44125225303247E7 | 1.30838270231471E7 | 9679200.3009757 | 1.32405397257932E7 |
| P01027 | Complement C3 [OS=Mus musculus] | 388.541 | 53 | 70 | 1148 | 62 | 1663 | 186.4 | cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular;other cell component | signal transduction activity or receptor binding;enzyme regulator activity | 12266 | ENSMUSG00000024164 | C3 | mmu:12266; P01027; Q61370; Q80XP1 | Complement activation, classical pathway; Tyrobp causal network in microglia; Comprehensive IL-17A signaling | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade; Neutrophil degranulation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; G alpha (i) signalling events; Peptide ligand-binding receptors; Alternative complement activation; Activation of C3 and C5 | 0.712660037675161 | 0.729783028721347 | 0.506101547380209 | 0.762068821001752 | 0.939492000987438 | 0.512232143465318 | 0.413470300505934 | 0.991722673088443 | 4040096.73815256 | 3926631.83282415 | 1843021.41157313 | 4.04154698805798E7 | 4.4896658832648E7 | 4.8335201547635E7 | 1.80671896153384E7 | 1.47828809765086E7 | 1.7121367805152E7 | 9.88883606977539E7 | 8.1974398309486E7 | 5.99376709525504E7 | 3.21393016835685E7 | 2.84159228355073E7 | 4.96444404075474E7 |
| Cont_Q7SIH1 | Alpha-2-macroglobulin OS=Bos taurus OX=9913 GN=A2M PE=1 SV=2 | 370.864 | 53 | 56 | 1089 | 56 | 1510 | 167.5 | non-structural extracellular | enzyme regulator activity;other molecular function | 513856 | ENSBTAG00000018137 | A2M | A8E647; bta:513856; Q7SIH1 | IL-6 signaling pathway | 0.688450665125024 | 0.839052280267302 | 0.731111241255251 | 0.509007335932165 | 0.944154202827561 | 0.540124873725708 | 0.671798309985569 | 0.809503222445875 | 5.71770657169572E7 | 6.35766951637367E7 | 4.19549690627817E7 | 6.46032237401637E7 | 7.37926671048822E7 | 7.2164410166051E7 | 8.06000315293491E7 | 7.23429494984619E7 | 7.40068576999505E7 | 8.7810317845685E7 | 9.50258669209954E7 | 6.46884849507494E7 | 4.10565401116459E7 | 3.96461495018234E7 | 7.63451634810678E7 | ||
| P68510 | 14-3-3 protein eta [OS=Mus musculus] | 64.921 | 53 | 12 | 224 | 7 | 246 | 28.2 | cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes | plasma membrane;other membranes;cytosol;mitochondrion;other cell component | cytoskeletal activity;other molecular function | 22629 | ENSMUSG00000018965 | Ywhah | mmu:22629; P11576; P68510; P70198; Q3TGZ9 | Myometrial relaxation and contraction pathways; Alpha 6 beta 4 integrin signaling pathway; Calcium regulation in cardiac cells | TP53 Regulates Metabolic Genes; Activation of BAD and translocation to mitochondria ; RHO GTPases activate PKNs; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.944154202827561 | 0.869908412860824 | 0.901149690306505 | 0.80954066750699 | 866773.880513068 | 694957.34543049 | 528233.86994798 | 459099.803564724 | 336630.897381686 | 625139.874551717 | 1680014.83549611 | 1370635.53518424 | 1070075.78560199 | 411442.579490808 | 389261.929304593 | 434172.721834376 | |||
| P68254 | 14-3-3 protein theta [OS=Mus musculus] | 62.581 | 53 | 12 | 235 | 6 | 245 | 27.8 | signal transduction;other biological processes | cytosol;nucleus;other cell component | other molecular function | 22630 | ENSMUSG00000076432 | Ywhaq | mmu:22630; P35216; P68254; Q3TW69; Q3UJN5; Q5SP76; Q5U423; Q66JR6 | Primary focal segmental glomerulosclerosis (FSGS); Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells | TP53 Regulates Metabolic Genes; Activation of BAD and translocation to mitochondria ; RHO GTPases activate PKNs; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Regulation of localization of FOXO transcription factors | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.829734761131295 | 0.987212456243842 | 0.947768687612402 | 0.111289914871169 | 811494.060532178 | 1160025.64990226 | 687138.145998916 | 323208.495396455 | 266808.020378426 | 588690.429375452 | 2790947.38639894 | 2126368.5130483 | 1602263.69915333 | 737300.291971803 | 488218.38641787 | 813808.362626944 | |||
| P10639 | Thioredoxin [OS=Mus musculus] | 23.642 | 52 | 4 | 72 | 4 | 105 | 11.7 | other metabolic processes;stress response;other biological processes | non-structural extracellular;cytosol;nucleus;other cell component | other molecular function | 22166 | ENSMUSG00000028367 | Txn | mmu:22166; P10639; Q52KC4; Q9D8R0 | Oxidative stress and redox pathway | TP53 Regulates Metabolic Genes; Interconversion of nucleotide di- and triphosphates; Detoxification of Reactive Oxygen Species; Oxidative Stress Induced Senescence; Protein repair; The NLRP3 inflammasome | 1.65082956259427E-17 | 0.00669448551858978 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.850917681937748 | 0.877818946381645 | 0.937453377971347 | 0.557162779351822 | 41188.8256347366 | 62810.4731690741 | 69722.3097873949 | 3963132.70276491 | 4250080.74892895 | 3277681.33381362 | 2070313.26068679 | 1605081.7083092 | 2257186.20178381 | 1.15144437335734E7 | 1.06031844207169E7 | 8311020.99510969 | 2469095.68758122 | 1725699.50911632 | 3517034.96471403 |
| Q01853 | Transitional endoplasmic reticulum ATPase [OS=Mus musculus] | 179.055 | 52 | 32 | 411 | 32 | 806 | 89.3 | cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;other biological processes | other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;enzyme regulator activity;other molecular function | 269523 | ENSMUSG00000028452 | Vcp | mmu:269523; Q01853; Q3TFH9; Q3TIM2; Q3TXN9; Q6PI18; Q8BSR6; Q8CEG4 | IL-9 signaling pathway | RHOH GTPase cycle; Neutrophil degranulation; Protein methylation; Ovarian tumor domain proteases; Neddylation; ABC-family proteins mediated transport; Translesion Synthesis by POLH; Hedgehog ligand biogenesis; KEAP1-NFE2L2 pathway; HSF1 activation; N-glycan trimming in the ER and Calnexin/Calreticulin cycle; Josephin domain DUBs | 0.915230778358139 | 0.645007535999596 | 0.808626104853287 | 0.953867932777128 | 0.953038161729767 | 0.877818946381645 | 0.901149690306505 | 0.737824045087029 | 462345.280919521 | 876653.458620268 | 526426.850526767 | 1.01571081063743E7 | 9889323.38925712 | 7942233.31155878 | 4702185.44070802 | 4580279.55870278 | 6732778.24078372 | 1.50535993864462E7 | 1.350776734351E7 | 9751498.62422888 | 4128956.06599177 | 3881002.94215154 | 5380991.32313934 |
| Q60605 | Myosin light polypeptide 6 [OS=Mus musculus] | 37.443 | 52 | 7 | 128 | 7 | 151 | 16.9 | other biological processes | cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 17904 | ENSMUSG00000090841 | Myl6 | mmu:17904; Q60605 | Focal adhesion | Smooth Muscle Contraction; RHO GTPases activate PAKs | 0.17954279960394 | 0.0597174367248522 | 0.201227492083465 | 0.11406862536513 | 0.974827674952665 | 0.877818946381645 | 0.969838013602216 | 0.901489646134689 | 11161.9883314762 | 44510.5971347212 | 2084535.0596028 | 2100098.50880368 | 1345595.20705123 | 1174902.84347918 | 991676.675961175 | 1551381.67808176 | 3464371.70742686 | 3457566.84497288 | 2726353.85272463 | 1564297.57799137 | 827028.966562118 | 1705156.18172858 | |
| P48036 | Annexin A5 [OS=Mus musculus] | 62.988 | 52 | 13 | 142 | 13 | 319 | 35.7 | stress response;other biological processes | non-structural extracellular;plasma membrane;other membranes | other molecular function | 11747 | ENSMUSG00000027712 | Anxa5 | mmu:11747; P48036; Q3U5Q1; Q3U5X4; Q3U8K1; Q3UGV0; Q99LA1 | Prostaglandin synthesis and regulation | Platelet degranulation | 0.962729299537276 | 0.964743998810065 | 0.649716058260961 | 0.826927610267147 | 0.934852211695135 | 0.993131538222517 | 0.85946611802464 | 0.941015048843842 | 132596.068853932 | 144295.425355019 | 72047.968900453 | 1566862.03559226 | 2586796.57910424 | 2492469.51394109 | 1494694.7163126 | 1254384.02027252 | 1254515.80206169 | 4847425.50967578 | 5026917.54031612 | 4160871.35356632 | 1581239.93399408 | 1845719.33352807 | 2646905.70386385 |
| P47955 | Large ribosomal subunit protein P1 [OS=Mus musculus] | 30.889 | 52 | 2 | 19 | 2 | 114 | 11.5 | protein metabolism;other metabolic processes;other biological processes | cytosol;translational apparatus;other cell component | other molecular function | 56040 | ENSMUSG00000007892 | Rplp1 | mmu:56040; P47955 | Cytoplasmic ribosomal proteins | L13a-mediated translational silencing of Ceruloplasmin expression; SRP-dependent cotranslational protein targeting to membrane; Major pathway of rRNA processing in the nucleolus and cytosol; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 1.65082956259427E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.850917681937748 | 5.07936507936508E-17 | 5.0092807424594E-17 | 0.0701816001240928 | 82669.4992701545 | 65144.4636720168 | 155926.075900288 | 292480.554672862 | 9052.36634659204 | |||||||||||
| Q9R0P5 | Destrin [OS=Mus musculus] | 37.385 | 52 | 9 | 95 | 8 | 165 | 18.5 | cell organization and biogenesis;other biological processes | cytoskeleton;other cell component | cytoskeletal activity | 56431 | ENSMUSG00000015932 | Dstn | mmu:56431; Q9R0P5 | 0.624017478365996 | 0.565681144660315 | 0.933133994208656 | 0.872856628412806 | 0.873755746039336 | 0.823375259461247 | 0.870511801558508 | 0.598108737233685 | 18629.9800934308 | 16103.0559745737 | 10491.4958491576 | 1084285.90835057 | 1052692.4849104 | 930814.809929399 | 441595.426509515 | 603047.113175247 | 1028865.739982 | 2709485.36834431 | 1870694.59731736 | 2153074.98222179 | 423599.428908783 | 551014.772778044 | 937220.476472916 | ||
| P62806 | Histone H4 [OS=Mus musculus] | 28.854 | 51 | 6 | 141 | 6 | 103 | 11.4 | cell organization and biogenesis;other biological processes | nucleus;other cell component | nucleic acid binding activity;other molecular function | 100041230; 319155; 319156; 319157; 319158; 319159; 319160; 319161; 320332; 326619; 326620; 69386; 97122 | ENSMUSG00000060093; ENSMUSG00000060639; ENSMUSG00000060678; ENSMUSG00000060981; ENSMUSG00000061482; ENSMUSG00000064288; ENSMUSG00000067455; ENSMUSG00000069266; ENSMUSG00000069274; ENSMUSG00000069305; ENSMUSG00000069306; ENSMUSG00000091405; ENSMUSG00000096010 | H4c1; H4c11; H4c12; H4c14; H4c16; H4c2; H4c3; H4c4; H4c6; H4c8; H4c9; Hist1h4m | A0AUM5; A4FUP8; A4QMY0; mmu:100041230; mmu:319155; mmu:319156; mmu:319157; mmu:319158; mmu:319159; mmu:319160; mmu:319161; mmu:320332; mmu:326619; mmu:326620; mmu:69386; mmu:97122; P02304; P02305; P62806; Q0VDL9; Q2M2Q5; Q5T006; Q6PDS7; Q811M0; Q9D0C9; Q9D6Q8 | Type II interferon signaling (IFNG) | RMTs methylate histone arginines; Regulation of endogenous retroelements by KRAB-ZFP proteins; SUMOylation of chromatin organization proteins; Recognition and association of DNA glycosylase with site containing an affected purine; Cleavage of the damaged purine; Condensation of Prophase Chromosomes; DNA Damage/Telomere Stress Induced Senescence; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Nonhomologous End-Joining (NHEJ); Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Inhibition of DNA recombination at telomere; PKMTs methylate histone lysines; Deposition of new CENPA-containing nucleosomes at the centromere; HDACs deacetylate histones; HATs acetylate histones; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Estrogen-dependent gene expression; PRC2 methylates histones and DNA; Negative Regulation of CDH1 Gene Transcription; MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis; HDMs demethylate histones | 0.418336752208667 | 0.94042169150467 | 1.50457038391225E-17 | 0.241544210438834 | 0.209371478859288 | 0.0543182519985559 | 3.35547127108615E-4 | 0.925789913630174 | 330396.220987003 | 352301.569568663 | 434120.452166522 | 1491132.80768763 | 2764739.76367265 | 2388107.47241261 | 444920.639624805 | 413584.046050742 | 428807.558440276 | 1.10244285236545E7 | 1.05125763785661E7 | 8104617.87119501 | 3832098.99177262 | 2274315.39690736 | 6138492.6632106 |
| P09528 | Ferritin heavy chain [OS=Mus musculus] | 35.812 | 51 | 8 | 107 | 8 | 182 | 21.1 | transport;other biological processes | non-structural extracellular;other membranes;cytosol;other cytoplasmic organelle;other cell component | other molecular function | 14319 | ENSMUSG00000024661 | Fth1 | mmu:14319; P09528; Q3UI44 | Iron homeostasis | Golgi Associated Vesicle Biogenesis; Neutrophil degranulation; Iron uptake and transport | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.36338274194713 | 0.90689241393859 | 0.941560341878142 | 0.0189080413265164 | 11415.1978386791 | 28293.3100342271 | 1453202.35191744 | 1665370.20752275 | 2136960.03887089 | 1094619.17678832 | 1071794.5819197 | 1209435.50405188 | 8429916.92726459 | 7005658.83506906 | 5770731.87743088 | 1166037.42857518 | 1124992.7984086 | 1227403.44254746 | |
| Cont_P13647 | Keratin, type II cytoskeletal 5 OS=Homo sapiens OX=9606 GN=KRT5 PE=1 SV=3 | 142.395 | 51 | 34 | 500 | 20 | 590 | 62.3 | cell organization and biogenesis;other biological processes | cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;cytoskeletal activity;other molecular function | 3852 | ENSG00000186081 | KRT5 | hsa:3852; P13647; Q6PI71; Q6UBJ0; Q8TA91 | Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin; Developmental Lineage of Mammary Stem Cells; Developmental Lineage of Mammary Gland Myoepithelial Cells; Type I hemidesmosome assembly | 0.786915923361782 | 0.847457711018997 | 0.707170943024881 | 0.746833150482801 | 0.873755746039336 | 0.714156118974909 | 0.2733017775894 | 2.49132633766938E-5 | 5120503.46953844 | 5171426.92187225 | 6553368.21772984 | 9669299.63907403 | 1.1127930529353E7 | 9127716.50969809 | 9513581.76230213 | 7584977.17814252 | 6506980.60696686 | 1.59683716443188E7 | 1.28154121523541E7 | 1.32126695164861E7 | 5.39600661696836E7 | 1.8678004759752E7 | 1.36191738010446E7 | |
| Q02819 | Nucleobindin-1 [OS=Mus musculus] | 131.152 | 51 | 21 | 299 | 21 | 459 | 53.4 | signal transduction | non-structural extracellular;other membranes;ER/Golgi | enzyme regulator activity;nucleic acid binding activity;other molecular function | 18220 | ENSMUSG00000030824 | Nucb1 | mmu:18220; Q02819; Q3TU42; Q9CWA1; Q9D8J4; Q9DBL3 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 0.130903496983571 | 0.0679830640731695 | 0.340647566778883 | 0.397987186613988 | 0.958122559708965 | 41072.7931792495 | 20198.6046706008 | 1.70846710933602E7 | 1.97547416617741E7 | 2.08807433533847E7 | 5757191.6972993 | 4828078.95450858 | 5895038.38978249 | 7136546.74332753 | 7387752.88718417 | 5120327.81590923 | 2637872.59598673 | 1130733.36645935 | 3369667.63744922 | ||
| P17918 | Proliferating cell nuclear antigen [OS=Mus musculus] | 50.145 | 51 | 10 | 72 | 10 | 261 | 28.8 | cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes | cytoskeleton;nucleus;other cell component | signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function | 18538 | ENSMUSG00000027342 | Pcna | mmu:18538; P17918 | Mismatch repair; Oxidative damage response; Primary focal segmental glomerulosclerosis (FSGS); G1 to S cell cycle control | SUMOylation of DNA replication proteins; Recognition of DNA damage by PCNA-containing replication complex; Dual Incision in GG-NER; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; E3 ubiquitin ligases ubiquitinate target proteins; Translesion Synthesis by POLH; Removal of the Flap Intermediate from the C-strand; HDR through Homologous Recombination (HRR); Polymerase switching on the C-strand of the telomere; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); PCNA-Dependent Long Patch Base Excision Repair; Termination of translesion DNA synthesis; Gap-filling DNA repair synthesis and ligation in GG-NER; Polymerase switching; Removal of the Flap Intermediate; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI | 0.47541602898497 | 0.381096727990464 | 0.826374720306471 | 0.887279041944908 | 0.976873891151678 | 0.875834610955903 | 0.801115710342179 | 0.960067393782086 | 30394.0784140218 | 28223.1432049833 | 51039.1401172933 | 1048820.20711846 | 801337.653436883 | 247250.67661959 | 374114.747314153 | 480325.704001997 | 735211.286888396 | 991704.93840689 | 1000418.19420179 | 610371.374274365 | 344506.254592942 | 153604.395914592 | 435556.607204553 |
| P11499 | Heat shock protein HSP 90-beta [OS=Mus musculus] | 164.719 | 50 | 29 | 532 | 19 | 724 | 83.2 | cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component | enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function | 15516 | ENSMUSG00000023944 | Hsp90ab1 | mmu:15516; O89078; P11499; Q3UIQ7 | Focal adhesion: PI3K-Akt-mTOR signaling pathway | Neutrophil degranulation; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of actin dynamics for phagocytic cup formation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Attenuation phase; Estrogen-dependent gene expression; Sema3A PAK dependent Axon repulsion; Aryl hydrocarbon receptor signalling; DDX58/IFIH1-mediated induction of interferon-alpha/beta; HSF1 activation; RHOBTB2 GTPase cycle; The NLRP3 inflammasome | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.952333191127893 | 0.385192173946943 | 0.975071223710592 | 0.476079393565723 | 221410.585638305 | 129165.68527882 | 147525.692220339 | 3.34627647115336E7 | 3.61961534999558E7 | 2.61391308788083E7 | 9541203.16877468 | 9273367.56835581 | 1.36082703259873E7 | 4.57710434253974E7 | 4.37708354854306E7 | 3.73056416942256E7 | 1.17622035416132E7 | 7437513.65495311 | 1.56244060515822E7 |
| Q64727 | Vinculin [OS=Mus musculus] | 182.753 | 50 | 45 | 419 | 45 | 1066 | 116.6 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | plasma membrane;other membranes;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 22330 | ENSMUSG00000021823 | Vcl | mmu:22330; Q64727; Q8BP32; Q8BS46; Q922C5; Q922D9 | Primary focal segmental glomerulosclerosis (FSGS); IL-3 signaling pathway; Regulation of actin cytoskeleton; Integrin-mediated cell adhesion; Focal adhesion | Neutrophil degranulation; High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells; Platelet degranulation ; MAP2K and MAPK activation; Smooth Muscle Contraction; Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells; Regulation of CDH1 Function | 0.208404050858596 | 0.190838415616571 | 0.238791978742132 | 0.504745711776551 | 0.964629994744883 | 0.878264980963866 | 0.977491813528386 | 0.958518237573655 | 199164.849916128 | 87100.0128702587 | 92185.322880836 | 5675245.0989599 | 5838625.66584249 | 3008640.49360623 | 1870082.63283096 | 1414114.90526218 | 2577750.73562883 | 7844023.43396073 | 7226639.25078312 | 5204108.91618431 | 2343388.9049214 | 1587883.53032107 | 3146179.30802337 |
| Cont_P12763 | Alpha-2-HS-glycoprotein OS=Bos taurus OX=9913 GN=AHSG PE=1 SV=2 | 132.772 | 50 | 16 | 1191 | 16 | 359 | 38.4 | stress response;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component | enzyme regulator activity | 280988 | AHSG | A6QLF7; bta:280988; P12763 | Neutrophil degranulation; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 0.573667790345329 | 0.793013134473823 | 0.624272910267193 | 0.36488675645736 | 0.946568086066385 | 0.268930374946741 | 0.335956814949331 | 0.913214993335179 | 6.75081036645858E8 | 9.56771805796805E8 | 4.32862555462728E8 | 6.04790296716478E8 | 6.42824998486085E8 | 6.76887564991134E8 | 8.54466282868744E8 | 8.4303805016043E8 | 9.16216503216691E8 | 7.41908408260606E8 | 7.48114705273509E8 | 6.29285280642112E8 | 3.25834950231514E8 | 3.42283489676807E8 | 6.64083343401506E8 | ||
| Q9JJH1 | Ribonuclease 4 [OS=Mus musculus] | 40.55 | 50 | 5 | 68 | 5 | 148 | 17 | stress response | nucleic acid binding activity;other molecular function | Rnase4 | Q9JJH1 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.405171272046276 | 0.97873503980026 | 0.319352164925032 | 0.990873516209569 | 900667.538795762 | 626495.60020001 | 674430.457749758 | 662460.788807247 | 418296.869814139 | 357229.483785163 | 806175.295812985 | 559706.117690068 | 632695.69219141 | 162317.682356543 | 82344.2531139482 | 351979.742895469 | ||||||||
| Q62356 | Follistatin-related protein 1 [OS=Mus musculus] | 101.698 | 50 | 13 | 395 | 13 | 306 | 34.5 | other biological processes | other molecular function | 14314 | ENSMUSG00000022816 | Fstl1 | mmu:14314; Q62356; Q6GTX2; Q99JI9 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Signaling by BMP | 0.234155704553915 | 0.76011950876399 | 0.758743075163871 | 0.858718647932906 | 0.0316468709291523 | 0.64816721735177 | 0.0857649907305965 | 0.896996950298791 | 41191.3351778335 | 108686.460674569 | 6.60207465015646E7 | 8.29713475942257E7 | 1.0059723968955E8 | 3.32110573276478E7 | 2.78551354522178E7 | 3.32507182180078E7 | 2.69623700732219E7 | 2.59261419226059E7 | 2.01925652875171E7 | 8207327.88504086 | 3463595.51170135 | 1.55118780287692E7 | |||
| Q9DBJ1 | Phosphoglycerate mutase 1 [OS=Mus musculus] | 66.001 | 50 | 9 | 141 | 9 | 254 | 28.8 | other metabolic processes | cytosol | other molecular function | 18648 | ENSMUSG00000011752 | Pgam1 | mmu:18648; Q9D6W0; Q9DBJ1; Q9ERT3 | Glycolysis and gluconeogenesis | Neutrophil degranulation; Gluconeogenesis; Glycolysis | 0.924864918132342 | 0.864213133022801 | 0.975483104913309 | 0.960450265090932 | 0.974827674952665 | 0.916542675526027 | 0.878843662685239 | 0.845300575646214 | 142576.777637381 | 198989.798164436 | 179788.671508667 | 2533554.33709426 | 2890204.49008964 | 2276325.08551472 | 1021326.4396357 | 939216.255648303 | 1157962.44230927 | 2843510.34247197 | 4617230.42091798 | 3461989.40298788 | 1602217.88853036 | 1109233.08749405 | 2483926.33322519 |
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| Accession | Description | Sum PEP Score | Coverage [%] | # Peptides | # PSMs | # Unique Peptides | # AAs | MW [kDa] | Biological Process | Cellular Component | Molecular Function | Entrez Gene ID | Ensembl Gene ID | Gene Symbol | Gene ID | WikiPathways | Reactome Pathways | Abundance Ratio: (LQ_16h) / FM | Abundance Ratio: (LQ_6h) / FM | Abundance Ratio: (SQ_16h) / FM | Abundance Ratio: (SQ_6h) / FM | Abundance Ratio: (SQ_16h) / (LQ_16h) | Abundance Ratio: (LQ_16h) / (LQ_6h) | Abundance Ratio: (SQ_6h) / (LQ_6h) | Abundance Ratio: (SQ_16h) / (SQ_6h) | Abundance Ratio Adj. P-Value: (LQ_16h) / FM | Abundance Ratio Adj. P-Value: (LQ_6h) / FM | Abundance Ratio Adj. P-Value: (SQ_16h) / FM | Abundance Ratio Adj. P-Value: (SQ_6h) / FM | Abundance Ratio Adj. P-Value: (SQ_16h) / (LQ_16h) | Abundance Ratio Adj. P-Value: (LQ_16h) / (LQ_6h) | Abundance Ratio Adj. P-Value: (SQ_6h) / (LQ_6h) | Abundance Ratio Adj. P-Value: (SQ_16h) / (SQ_6h) | Abundances (Normalized): F1: Sample, FM | Abundances (Normalized): F2: Sample, FM | Abundances (Normalized): F3: Sample, FM | Abundances (Normalized): F8: Sample, LQ_16h | Abundances (Normalized): F9: Sample, LQ_16h | Abundances (Normalized): F10: Sample, LQ_16h | Abundances (Normalized): F4: Sample, LQ_6h | Abundances (Normalized): F5: Sample, LQ_6h | Abundances (Normalized): F6: Sample, LQ_6h | Abundances (Normalized): F17: Sample, SQ_16h | Abundances (Normalized): F18: Sample, SQ_16h | Abundances (Normalized): F20: Sample, SQ_16h | Abundances (Normalized): F14: Sample, SQ_6h | Abundances (Normalized): F15: Sample, SQ_6h | Abundances (Normalized): F16: Sample, SQ_6h |
| P11276 | Fibronectin [OS=Mus musculus] | 867.353 | 58 | 95 | 2246 | 59 | 2477 | 272.4 | cell adhesion;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi | signal transduction activity or receptor binding;enzyme regulator activity;other molecular function | 14268 | ENSMUSG00000026193 | Fn1 | G5E8B8; mmu:14268; P11276; Q61567; Q61568; Q61569; Q64233; Q80UI4 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Inflammatory response pathway; Regulation of actin cytoskeleton; Comprehensive IL-17A signaling; Focal adhesion | ECM proteoglycans; Platelet degranulation ; Cell surface interactions at the vascular wall; Syndecan interactions; MAP2K and MAPK activation; Integrin cell surface interactions; Molecules associated with elastic fibres; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Fibronectin matrix formation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; Degradation of the extracellular matrix; Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells; MET activates PTK2 signaling; GPER1 signaling | 16.191 | 18.678 | 20 | 12.982 | 1.439 | 0.984 | 0.516 | 2.74 | 0.0844744457809114 | 0.00584906503121538 | 1.50457038391225E-17 | 0.156115961659409 | 0.974036928885484 | 0.564710097967506 | 0.435823028559966 | 0.896613838854506 | 3.10111960161575E7 | 2.79853612635427E7 | 2.39278028537136E7 | 2.27076161669542E8 | 2.29530848002383E8 | 1.81481696567249E8 | 2.13523563015262E8 | 1.92386583493888E8 | 2.00792310651879E8 | 3.0604731494329E8 | 2.72875123758133E8 | 2.45952285820886E8 | 1.1928889459527E8 | 1.00071254189999E8 | 1.59531432686856E8 |
| P11087 | Collagen alpha-1(I) chain [OS=Mus musculus] | 797.017 | 79 | 75 | 1933 | 35 | 1453 | 137.9 | cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12842 | ENSMUSG00000001506 | Col1a1 | mmu:12842; P11087; Q53WT0; Q60635; Q61367; Q61427; Q63919; Q6PCL3; Q810J9 | Osteoblast signaling; Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Comprehensive IL-17A signaling; Focal adhesion | Cell surface interactions at the vascular wall; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ECM proteoglycans; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; GPVI-mediated activation cascade; GP1b-IX-V activation signalling; Platelet Adhesion to exposed collagen; Platelet Aggregation (Plug Formation); MET activates PTK2 signaling | 20 | 20 | 20 | 20 | 0.142 | 3.208 | 0.295 | 1.664 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 1.58880673198775E-4 | 0.381922652011049 | 0.0629214061377862 | 0.655833157547641 | 703080.609341466 | 1047026.5902454 | 567207.050774397 | 6.12803341835757E8 | 6.28616080368892E8 | 5.37143706349406E8 | 2.20652487774689E8 | 1.86114398805651E8 | 2.17194307013081E8 | 9.46570689754052E7 | 9.72166914362706E7 | 6.09758172025116E7 | 6.01286898886734E7 | 4.84358218594371E7 | 7.06441702532683E7 |
| Q01149 | Collagen alpha-2(I) chain [OS=Mus musculus] | 773.662 | 80 | 66 | 1731 | 51 | 1372 | 129.5 | cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12843 | ENSMUSG00000029661 | Col1a2 | mmu:12843; Q01149; Q8CGA5 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Focal adhesion | Crosslinking of collagen fibrils; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; ECM proteoglycans; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; GPVI-mediated activation cascade; GP1b-IX-V activation signalling; Platelet Adhesion to exposed collagen; Platelet Aggregation (Plug Formation); MET activates PTK2 signaling | 20 | 20 | 20 | 20 | 0.279 | 2.097 | 0.261 | 2.151 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.0150838661305169 | 0.862063111456553 | 0.0347692006632991 | 0.926292871155025 | 217896.573253055 | 102775.453905646 | 225868.955510701 | 3.82374533805921E8 | 3.80614155239716E8 | 2.79801552870279E8 | 1.73556920519588E8 | 1.55763113653521E8 | 1.89931753802048E8 | 1.03217412397752E8 | 1.04517075360638E8 | 6.33578194684048E7 | 4.96147162399626E7 | 2.65479311979207E7 | 5.19818116295111E7 |
| P08121 | Collagen alpha-1(III) chain [OS=Mus musculus] | 695.631 | 63 | 61 | 1789 | 51 | 1464 | 138.9 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | extracellular matrix;other cell component | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 12825 | ENSMUSG00000026043 | Col3a1 | mmu:12825; P08121; Q61429; Q9CRN7 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Focal adhesion | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ECM proteoglycans; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; MET activates PTK2 signaling | 20 | 20 | 20 | 20 | 0.247 | 5.055 | 0.497 | 2.464 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.00738207855214502 | 0.0413994480640273 | 0.394949139624895 | 0.976852696203657 | 619884.023482232 | 468692.52789102 | 275667.802679115 | 2.79020579584843E8 | 2.94236692581693E8 | 2.78582579285209E8 | 6.51340156000414E7 | 5.70632610319163E7 | 6.62894421161806E7 | 7.54516142044654E7 | 7.68700494785543E7 | 4.61499837269909E7 | 3.06665885804687E7 | 2.39448217703501E7 | 3.64849658219652E7 |
| Q9QXS1 | Plectin [OS=Mus musculus] | 659.702 | 46 | 182 | 1705 | 180 | 4691 | 533.9 | cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component | cytoskeletal activity;other molecular function | 18810 | ENSMUSG00000022565 | Plec | E9QN87; mmu:18810; Q6S384; Q6S389; Q6S394; Q9CS65; Q9QUT2; Q9QXQ8; Q9QXQ9; Q9QXR0; Q9QXR1; Q9QXR2; Q9QXR3; Q9QXR4; Q9QXR5; Q9QXR6; Q9QXR7; Q9QXR8; Q9QXR9; Q9QXS0; Q9QXS1; Q9QXS2; Q9QXS3 | Alpha 6 beta 4 integrin signaling pathway; EGFR1 signaling pathway | Type I hemidesmosome assembly; Caspase-mediated cleavage of cytoskeletal proteins | 5.459 | 2.593 | 9.846 | 4.989 | 2.383 | 2.864 | 1.839 | 3.715 | 0.481729871164266 | 0.714932595871944 | 0.336550483871782 | 0.572524806937582 | 0.850917681937748 | 0.532399788858771 | 0.702330308974487 | 0.520376293994664 | 307407.817065559 | 282192.990008148 | 340166.735457239 | 1.95783440606639E7 | 1.89230076526173E7 | 1.15266683074569E7 | 3962115.44279651 | 3474477.32513512 | 6361226.57462356 | 5.1842207663806E7 | 4.48709077668655E7 | 3.18339270889303E7 | 1.10137014373925E7 | 7604177.6415354 | 1.18325057871337E7 |
| P08122 | Collagen alpha-2(IV) chain [OS=Mus musculus] | 526.992 | 64 | 69 | 1077 | 69 | 1707 | 167.2 | RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix | extracellular structural activity | 12827 | ENSMUSG00000031503 | Col4a2 | mmu:12827; P08122; Q3B7C2; Q3TPV9; Q61375; Q66JS5; Q6RCT6; Q6RCT7; Q6U9X1; Q8BPI9; Q8BPK3; Q91VI3 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Focal adhesion | Laminin interactions; Signaling by PDGF; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions | 7.029 | 2.876 | 10.91 | 3.309 | 1.603 | 3.934 | 1.208 | 3.852 | 0.352816378116182 | 0.64759425713406 | 0.293387877727491 | 0.79866917976589 | 0.979628232635575 | 0.169673447599406 | 0.959159975702413 | 0.483015668880262 | 1499335.01530309 | 1691518.00623855 | 989751.415380184 | 5.53234274481973E7 | 5.88619201086468E7 | 3.63990683013196E7 | 1.35123643610626E7 | 1.30555597235297E7 | 1.53773176128868E7 | 6.80333035906639E7 | 6.55922447276284E7 | 4.55601360762201E7 | 1.71661195678148E7 | 9511844.25395737 | 2.43703078917008E7 |
| Q3U962 | Collagen alpha-2(V) chain [OS=Mus musculus] | 518.514 | 64 | 57 | 817 | 55 | 1497 | 144.9 | cell organization and biogenesis;developmental processes;other biological processes | extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12832 | ENSMUSG00000026042 | Col5a2 | mmu:12832; Q3TVR2; Q3U962; Q3UHK7; Q3UTT4; Q3V1J6; Q61431; Q7TMS0; Q80VS8 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions | 1.598 | 1.546 | 1.519 | 1.021 | 0.385 | 3.505 | 0.525 | 2.477 | 0.861384746267066 | 0.961254912149485 | 0.730324052254867 | 0.632833892117728 | 0.0769666553885184 | 0.273444295895674 | 0.453486790198347 | 0.973358018692255 | 1.96082795853326E7 | 1.89754303457921E7 | 3.46758133166589E7 | 4.80275081428664E7 | 4.79991185130461E7 | 4.1747532446715E7 | 1.59204573672189E7 | 1.42782577106181E7 | 1.7061559679881E7 | 2.09575588581227E7 | 1.96948053072084E7 | 2.25862916575107E7 | 1.85137908486988E7 | 4881772.8383399 | 8018525.34642114 |
| Q05793 | Basement membrane-specific heparan sulfate proteoglycan core protein [OS=Mus musculus] | 507.28 | 33 | 84 | 998 | 84 | 3707 | 398 | cell organization and biogenesis;transport;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;ER/Golgi | other molecular function | 15530 | Hspg2 | mmu:15530; Q05793 | 7.351 | 4.161 | 3.918 | 5.169 | 0.496 | 1.868 | 0.437 | 2.1 | 0.332090710292395 | 0.382764581022518 | 0.771134174410141 | 0.553652046981626 | 0.208890689478245 | 0.938381933295379 | 0.285967432697218 | 0.908661395894721 | 136795.508290338 | 206406.403199821 | 169825.859706297 | 3.70110206606215E7 | 4.34630743166815E7 | 4.28074794537461E7 | 2.41165287907714E7 | 1.91842080304052E7 | 2.07659482289725E7 | 2.10452863152835E7 | 2.06741361608803E7 | 1.52751209810576E7 | 8226367.86740312 | 5927226.99682882 | 1.0580617159021E7 | |||
| Q61554 | Fibrillin-1 [OS=Mus musculus] | 499.202 | 38 | 86 | 1117 | 86 | 2873 | 312.1 | cell adhesion;other metabolic processes;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 14118 | ENSMUSG00000027204 | Fbn1 | A2AQ53; mmu:14118; Q60826; Q61554 | Comprehensive IL-17A signaling | Integrin cell surface interactions; Degradation of the extracellular matrix; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; TGF-beta receptor signaling activates SMADs; Molecules associated with elastic fibres | 18.996 | 8.247 | 8.911 | 3.018 | 0.396 | 2.1 | 0.276 | 3.153 | 0.0596853092747711 | 0.0840496117897429 | 0.378389090130589 | 0.84258396038376 | 0.087482121441914 | 0.862063111456553 | 0.0455630470425967 | 0.77820123247099 | 95282.9912894267 | 109686.773968107 | 40225.7464170883 | 5.82457893686458E7 | 6.62931141873392E7 | 3.19536333419291E7 | 2.33066180631659E7 | 1.9035713753758E7 | 2.29784126659734E7 | 2.39841959808407E7 | 2.29999435869113E7 | 1.54925740961197E7 | 5514536.56061601 | 2575605.08863811 | 7345083.32475891 |
| Q8BTM8 | Filamin-A [OS=Mus musculus] | 493.069 | 49 | 91 | 915 | 83 | 2647 | 281 | cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;other molecular function | 192176 | ENSMUSG00000031328 | Flna | B7FAV0; O54934; Q7TQI1; Q8BLK1; Q8BTM8; Q8BTN7; Q8VHX5; Q8VHX8; Q99KQ2 | Mapk signaling pathway; Focal adhesion | Platelet degranulation ; Cell-extracellular matrix interactions; RHO GTPases activate PAKs; GP1b-IX-V activation signalling | 16.184 | 3.535 | 15.745 | 4.108 | 1.303 | 2.08 | 0.901 | 2.899 | 0.0844935092512095 | 0.493514006575528 | 0.170420349138264 | 0.67528135146603 | 0.946239447314336 | 0.864215513767001 | 0.904360680536565 | 0.8468455705593 | 223080.302738683 | 192779.021360071 | 239583.24348992 | 1.21506602248127E7 | 1.23160583881327E7 | 9719435.76620134 | 4325195.00464495 | 4176073.86658823 | 6355593.34436329 | 1.73054238441738E7 | 1.42527501066511E7 | 1.24998953996761E7 | 4531038.34565544 | 2879720.55833739 | 5479053.39146785 |
| P02463 | Collagen alpha-1(IV) chain [OS=Mus musculus] | 487.707 | 70 | 68 | 828 | 68 | 1669 | 160.6 | cell organization and biogenesis;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix | extracellular structural activity;other molecular function | 12826 | ENSMUSG00000031502 | Col4a1 | mmu:12826; P02463; Q3UHJ4; Q3UJE7; Q3UQV2; Q53X35; Q6GQS7; Q6PHB5; Q99LQ8 | Spinal cord injury; Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Laminin interactions; Signaling by PDGF; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions | 4.371 | 1.004 | 11.171 | 2.458 | 3.498 | 3.947 | 1.69 | 4.683 | 0.604225174343649 | 0.68008321917751 | 0.284160251285083 | 0.936818656936794 | 0.483508479481234 | 0.167300285011781 | 0.777395712279767 | 0.224623005929948 | 359769.877634713 | 285958.835932462 | 141085.539092917 | 2.00868956379824E7 | 2.17854047157598E7 | 2.25190928918174E7 | 4657081.16483192 | 4119739.1632835 | 5084724.84322114 | 3.91843343162395E7 | 3.69562703398771E7 | 2.33283395840594E7 | 7286914.931104 | 6193195.94075903 | 1.32557370999003E7 |
| Q60847 | Collagen alpha-1(XII) chain [OS=Mus musculus] | 480.266 | 40 | 95 | 991 | 95 | 3120 | 340 | cell adhesion;developmental processes | other cell component | 12816 | ENSMUSG00000032332 | Col12a1 | mmu:12816; P70322; Q60847 | Assembly of collagen fibrils and other multimeric structures; Collagen chain trimerization; Collagen degradation | 15.041 | 20 | 9.674 | 12.612 | 0.427 | 0.631 | 0.21 | 1.243 | 0.0975092237649803 | 1.8644578313253E-17 | 0.344512840834051 | 0.162753188077458 | 0.119424004207039 | 0.101350980560035 | 0.0103905836841461 | 0.266844028199729 | 98450.5264125119 | 58090.3600627237 | 83999.6481680613 | 3.34408474370425E7 | 3.89438836318894E7 | 1.74727378978336E7 | 5.74848700994307E7 | 4.49447732262548E7 | 5.27793485517261E7 | 1.71723257401258E7 | 1.50709974901674E7 | 1.16453026750935E7 | 1.0899125462023E7 | 6848854.24799245 | 1.38653609093446E7 | ||
| Q8VDD5 | Myosin-9 [OS=Mus musculus] | 418.364 | 45 | 73 | 827 | 60 | 1960 | 226.2 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;stress response;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;other molecular function | 17886 | ENSMUSG00000022443 | Myh9 | mmu:17886; Q3UHT9; Q3UHU4; Q6KAN6; Q811I2; Q8VDD5 | Primary focal segmental glomerulosclerosis (FSGS) | RHO GTPases activate PAKs; Regulation of actin dynamics for phagocytic cup formation | 11.694 | 10.853 | 19.492 | 13.21 | 2.21 | 1.427 | 1.339 | 2.347 | 0.156498497144098 | 0.0382609387499984 | 0.118876667035285 | 0.15125389278925 | 0.87421335771164 | 0.916542675526027 | 0.91728043005175 | 0.990873516209569 | 107483.529676039 | 153800.887463573 | 39674.4269878413 | 8783012.74886087 | 9974545.70796386 | 5444477.78467149 | 4748384.28257292 | 4410554.6604061 | 6370665.87897293 | 2.10207699044932E7 | 2.09758895852136E7 | 1.72823293907493E7 | 8538625.93793802 | 5517905.75659883 | 9476865.41359831 |
| Cont_P02453 | Collagen alpha-1(I) chain OS=Bos taurus OX=9913 GN=COL1A1 PE=1 SV=3 | 414.689 | 43 | 43 | 1208 | 4 | 1463 | 138.9 | cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | 282187 | ENSBTAG00000013103 | COL1A1 | bta:282187; P02453; Q3MHM2 | Inflammatory response pathway; Osteoblast signaling; Focal adhesion | Fibronectin matrix formation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Collagen degradation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; Collagen chain trimerization; GPVI-mediated activation cascade; Platelet Aggregation (Plug Formation); Platelet Adhesion to exposed collagen; GP1b-IX-V activation signalling | 1.443 | 0.869 | 1.124 | 1.501 | 0.374 | 1.284 | 0.335 | 0.775 | 0.800889767710788 | 0.579410556046386 | 0.58548007712969 | 0.839216523231753 | 0.067749585016969 | 0.848119069115724 | 0.108042253370914 | 0.0107964100780951 | 246464.336302772 | 276104.509600215 | 163058.776827813 | 4343807.62117337 | 4270443.00602544 | 3115927.46864821 | 3219828.72869598 | 3183952.03023541 | 3383679.40073467 | 941743.224351002 | 1075861.66368366 | 756862.710693879 | 1364509.18546901 | 876331.391932507 | 1065336.29340721 |
| Cont_P02769 | Albumin OS=Bos taurus OX=9913 GN=ALB PE=1 SV=4 | 390.555 | 81 | 57 | 7095 | 54 | 607 | 69.2 | stress response;other biological processes | non-structural extracellular;other cell component | nucleic acid binding activity;other molecular function | 280717 | ALB | A5PJX3; bta:280717; O02787; P02769; P04277; Q3SZR2 | 0.86 | 0.957 | 1.154 | 0.79 | 1.314 | 0.876 | 0.791 | 1.45 | 0.520832629933248 | 0.650544967914241 | 0.598172767155558 | 0.497906326712893 | 0.946568086066385 | 0.413798631523592 | 0.846117085258013 | 0.468531677746422 | 3.41035277502904E9 | 3.06531085647989E9 | 1.66716629813739E9 | 2.0547979326133E9 | 2.37062763488737E9 | 2.78500610382043E9 | 3.09362764542436E9 | 2.55631644026836E9 | 3.07992745656962E9 | 2.97814649224141E9 | 2.86277256421772E9 | 2.21144220575444E9 | 1.66052966718895E9 | 2.22855277531216E9 | 3.25384623573346E9 | |||
| P01027 | Complement C3 [OS=Mus musculus] | 388.541 | 53 | 70 | 1148 | 62 | 1663 | 186.4 | cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular;other cell component | signal transduction activity or receptor binding;enzyme regulator activity | 12266 | ENSMUSG00000024164 | C3 | mmu:12266; P01027; Q61370; Q80XP1 | Complement activation, classical pathway; Tyrobp causal network in microglia; Comprehensive IL-17A signaling | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade; Neutrophil degranulation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; G alpha (i) signalling events; Peptide ligand-binding receptors; Alternative complement activation; Activation of C3 and C5 | 3.547 | 2.537 | 6.803 | 3.529 | 1.878 | 2.911 | 2.425 | 2.35 | 0.712660037675161 | 0.729783028721347 | 0.506101547380209 | 0.762068821001752 | 0.939492000987438 | 0.512232143465318 | 0.413470300505934 | 0.991722673088443 | 4040096.73815256 | 3926631.83282415 | 1843021.41157313 | 4.04154698805798E7 | 4.4896658832648E7 | 4.8335201547635E7 | 1.80671896153384E7 | 1.47828809765086E7 | 1.7121367805152E7 | 9.88883606977539E7 | 8.1974398309486E7 | 5.99376709525504E7 | 3.21393016835685E7 | 2.84159228355073E7 | 4.96444404075474E7 |
| Cont_Q7SIH1 | Alpha-2-macroglobulin OS=Bos taurus OX=9913 GN=A2M PE=1 SV=2 | 370.864 | 53 | 56 | 1089 | 56 | 1510 | 167.5 | non-structural extracellular | enzyme regulator activity;other molecular function | 513856 | ENSBTAG00000018137 | A2M | A8E647; bta:513856; Q7SIH1 | IL-6 signaling pathway | 1.169 | 1.273 | 1.523 | 0.809 | 1.276 | 0.967 | 0.649 | 1.845 | 0.688450665125024 | 0.839052280267302 | 0.731111241255251 | 0.509007335932165 | 0.944154202827561 | 0.540124873725708 | 0.671798309985569 | 0.809503222445875 | 5.71770657169572E7 | 6.35766951637367E7 | 4.19549690627817E7 | 6.46032237401637E7 | 7.37926671048822E7 | 7.2164410166051E7 | 8.06000315293491E7 | 7.23429494984619E7 | 7.40068576999505E7 | 8.7810317845685E7 | 9.50258669209954E7 | 6.46884849507494E7 | 4.10565401116459E7 | 3.96461495018234E7 | 7.63451634810678E7 | ||
| Cont_Q29443 | Serotransferrin OS=Bos taurus OX=9913 GN=TF PE=2 SV=1 | 343.183 | 74 | 48 | 1709 | 46 | 704 | 77.7 | stress response;transport;other biological processes | non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle | other molecular function | 280705 | TF | bta:280705; Q0IIK2; Q29443 | 1.017 | 1.563 | 1.16 | 0.912 | 1.118 | 0.635 | 0.55 | 1.293 | 0.615274986253429 | 0.964709887217926 | 0.600414647182016 | 0.571407162236119 | 0.902231721267411 | 0.105569810421019 | 0.506704636011438 | 0.313748671859839 | 1.71679936327392E8 | 1.91001417946965E8 | 8.41149187199369E7 | 1.24867801818358E8 | 1.55146358811954E8 | 1.88178132242021E8 | 2.69795837029218E8 | 2.21755859229163E8 | 2.04768415701638E8 | 1.81082969779594E8 | 1.61167381210782E8 | 1.45463022007429E8 | 9.18433757916485E7 | 1.38609619584445E8 | 1.76572700073531E8 | |||
| Cont_P07589 | Fibronectin OS=Bos taurus OX=9913 GN=FN1 PE=1 SV=4 | 337.517 | 26 | 47 | 923 | 11 | 2478 | 272 | cell adhesion;cell organization and biogenesis;stress response;developmental processes;other biological processes | non-structural extracellular | signal transduction activity or receptor binding;other molecular function | FN1 | P07589 | 3.52 | 3.363 | 2.311 | 1.395 | 0.714 | 1.039 | 0.476 | 1.31 | 0.714071857030863 | 0.525827426782658 | 0.94971810013306 | 0.802863674292211 | 0.553450172742796 | 0.634088329627404 | 0.35834247597224 | 0.281927255363179 | 142865.797461343 | 209169.389049115 | 146732.075795441 | 1055759.20189889 | 1052518.92691246 | 748231.640959004 | 927817.269350189 | 797644.80797335 | 782189.414628216 | 683356.768802769 | 735882.167003896 | 388557.285212602 | 606468.327162644 | 334439.098432858 | 506951.879121439 | ||||
| Q80X90 | Filamin-B [OS=Mus musculus] | 335.882 | 38 | 75 | 608 | 66 | 2602 | 277.7 | cell organization and biogenesis;stress response;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 286940 | ENSMUSG00000025278 | Flnb | E9QNV9; mmu:286940; Q80X90; Q8VHX4; Q8VHX7; Q99KY3 | ISG15 antiviral mechanism | 7.928 | 5.332 | 12.124 | 4.491 | 1.209 | 1.979 | 0.842 | 2.845 | 0.296944306247309 | 0.238365792894698 | 0.254729742039053 | 0.629546282386664 | 0.936411452199724 | 0.897564267605108 | 0.872448101434609 | 0.866446545996913 | 201569.562939035 | 74814.3999578854 | 187488.727848728 | 5908241.65562211 | 7025090.54357015 | 5213153.27323614 | 2307098.04671866 | 1545558.91097354 | 3200680.70273347 | 8948631.41531232 | 7437294.37435051 | 6391778.7211006 | 1867290.64861647 | 1318356.62479586 | 2409815.97001446 | |
| Cont_P35527 | Keratin, type I cytoskeletal 9 OS=Homo sapiens OX=9606 GN=KRT9 PE=1 SV=3 | 310.424 | 69 | 35 | 915 | 34 | 623 | 62 | cell organization and biogenesis;other biological processes | cytosol;cytoskeleton | cytoskeletal activity | 3857 | ENSG00000171403 | KRT9 | hsa:3857; O00109; P35527; Q0IJ47; Q14665 | Formation of the cornified envelope | 1.535 | 1.081 | 1.647 | 2.287 | 1.044 | 1.471 | 2.208 | 0.777 | 0.836660982916281 | 0.73072258897653 | 0.769556732848094 | 0.964570089320365 | 0.873609880131656 | 0.936669139837906 | 0.516448827835279 | 0.0110179641295352 | 3.00988862408693E7 | 2.22166955848562E7 | 3.53566605858277E7 | 3.83413938796298E7 | 4.01115354911529E7 | 4.55013850626263E7 | 3.25056930591839E7 | 3.99576081794461E7 | 2.50556157717982E7 | 4.79768166310243E7 | 2.93517742058567E7 | 7.69722436015544E7 | 1.31711700890849E8 | 9.27838604678364E7 | 5.6604390657593E7 | |
| Cont_P04264 | Keratin, type II cytoskeletal 1 OS=Homo sapiens OX=9606 GN=KRT1 PE=1 SV=6 | 306.58 | 65 | 45 | 1774 | 36 | 644 | 66 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;other molecular function | 3848 | ENSG00000167768 | KRT1 | B2RA01; hsa:3848; P04264; P85925; P86104; Q14720; Q6GSJ0; Q9H298 | Corticotropin-releasing hormone signaling | Formation of the cornified envelope; Neutrophil degranulation; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 1.103 | 0.963 | 1.229 | 2.667 | 1.042 | 1.184 | 2.925 | 0.472 | 0.65780924735352 | 0.653826967689551 | 0.631165145316661 | 0.89629386854896 | 0.873609880131656 | 0.770634810212039 | 0.254077056479593 | 5.78940441291519E-5 | 1.31038801811221E8 | 1.49848314576813E8 | 1.81048519054156E8 | 1.64179912336924E8 | 1.70861004616453E8 | 1.60803236136221E8 | 1.32005397364365E8 | 1.61355773356369E8 | 1.09071204525108E8 | 1.84835731298625E8 | 1.38277867637903E8 | 2.0582953187505E8 | 6.47574942932283E8 | 3.95085049343759E8 | 3.00261678765842E8 |
| P06909 | Complement factor H [OS=Mus musculus] | 292.01 | 49 | 41 | 540 | 41 | 1234 | 139 | cell adhesion;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes | non-structural extracellular;plasma membrane;other membranes;mitochondrion;other cell component | other molecular function | 12628 | ENSMUSG00000026365 | Cfh | mmu:12628; P06909; Q6NZK3 | Regulation of Complement cascade | 10 | 11.089 | 20 | 8.058 | 2.955 | 0.961 | 0.704 | 3.964 | 0.205200089226065 | 0.0359547312524068 | 1.50457038391225E-17 | 0.329485122608543 | 0.678323397545056 | 0.532399788858771 | 0.750662231008662 | 0.443116920082088 | 45833.2314948132 | 5719.34924483144 | 127074.400703141 | 9199603.23733176 | 9631512.57691777 | 1.22513356989878E7 | 1.13946236540082E7 | 8948376.12127358 | 1.13575209573925E7 | 3.40837407850627E7 | 2.84575354110008E7 | 2.55312981422866E7 | 7658800.41775084 | 6857257.31092971 | 1.08034871236965E7 | |
| P16546 | Spectrin alpha chain, non-erythrocytic 1 [OS=Mus musculus] | 291.854 | 35 | 74 | 473 | 74 | 2472 | 284.4 | cell organization and biogenesis | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 20740 | ENSMUSG00000057738 | Sptan1 | A3KGU6; A3KGU8; P16546; Q8K380; Q9CT05 | FAS pathway and stress induction of HSP regulation | Neutrophil degranulation; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Interaction between L1 and Ankyrins; COPI-mediated anterograde transport; RHOU GTPase cycle; RHOV GTPase cycle; Caspase-mediated cleavage of cytoskeletal proteins | 2.273 | 1.172 | 5.466 | 1.689 | 1.972 | 2.321 | 1.488 | 2.88 | 0.958962194559628 | 0.786160319109602 | 0.611910908670005 | 0.890289034593217 | 0.929383260195332 | 0.771887919257916 | 0.870511801558508 | 0.852906094467594 | 889916.065158961 | 705414.766907556 | 458549.490375553 | 4175162.43226982 | 4600176.71769719 | 3155429.78771999 | 1301153.76848032 | 907755.21332001 | 2072924.21437361 | 9282178.93349268 | 8610756.12905297 | 6522130.81446154 | 2340149.67970916 | 1477626.07784989 | 2972528.81421804 |
| Cont_P13645 | Keratin, type I cytoskeletal 10 OS=Homo sapiens OX=9606 GN=KRT10 PE=1 SV=6 | 286.713 | 62 | 30 | 1322 | 20 | 584 | 58.8 | cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes | plasma membrane;cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;other molecular function | 3858 | ENSG00000186395 | KRT10 | hsa:3858; P13645; Q14664; Q8N175 | Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.992 | 0.771 | 1.072 | 2.427 | 0.958 | 1.365 | 2.951 | 0.443 | 0.600890052902075 | 0.490821286240141 | 0.561934876627864 | 0.941696908693733 | 0.829734761131295 | 0.880940844456856 | 0.246231694954624 | 2.55433624902191E-5 | 8.57039306780817E7 | 1.2308209015436E8 | 1.23973335952419E8 | 1.09050331614224E8 | 1.30109606828786E8 | 1.02692161896587E8 | 8.73473050095944E7 | 1.23031831133367E8 | 7.19147674496861E7 | 1.29238189237995E8 | 9.43248217623685E7 | 1.03859326412487E8 | 5.11249836753994E8 | 2.4676744393623E8 | 2.01230291385254E8 | |
| Cont_P35908 | Keratin, type II cytoskeletal 2 epidermal OS=Homo sapiens OX=9606 GN=KRT2 PE=1 SV=2 | 284.975 | 78 | 42 | 1022 | 32 | 639 | 65.4 | cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes | plasma membrane;cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;cytoskeletal activity | 3849 | ENSG00000172867 | KRT2 | hsa:3849; P35908; Q4VAQ2 | Formation of the cornified envelope | 0.827 | 0.688 | 1.032 | 1.836 | 1.146 | 1.306 | 2.733 | 0.542 | 0.499413631103761 | 0.411258958244596 | 0.544106843431104 | 0.933570718645937 | 0.912218866069753 | 0.862063111456553 | 0.309041843038519 | 2.9837536993241E-4 | 2.56957016834685E7 | 6.51011422173888E7 | 5.25056794690703E7 | 3.16465014359267E7 | 4.04662454773149E7 | 3.03458785296059E7 | 2.58420950665494E7 | 4.44581259999837E7 | 1.77732081549674E7 | 3.88601529372083E7 | 2.41897353529024E7 | 4.54682916268081E7 | 9.79668081708945E7 | 6.73715830359901E7 | 6.38856203067551E7 | |
| Q62059 | Versican core protein [OS=Mus musculus] | 279.715 | 17 | 44 | 1073 | 44 | 3357 | 366.6 | cell adhesion;developmental processes | non-structural extracellular;extracellular matrix;other cell component | other molecular function | Vcan | Q62058; Q62059; Q9CUU0 | ECM proteoglycans; Glycosaminoglycan-protein linkage region biosynthesis; CS/DS degradation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; CS-GAG biosynthesis; DS-GAG biosynthesis | 20 | 20 | 20 | 20 | 1.005 | 1.018 | 0.536 | 1.805 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.854305439376382 | 0.613304974369123 | 0.478009151463064 | 0.783304059803245 | 125473.726574878 | 146060.097046071 | 41031.8651630982 | 8.44868881898379E7 | 1.01917408783468E8 | 9.76252353450265E7 | 1.00104936351016E8 | 8.17450473009677E7 | 8.92610512588614E7 | 1.04839173391366E8 | 1.06605513712809E8 | 7.38631920533055E7 | 5.09261453344577E7 | 4.44571187520766E7 | 8.14544543672178E7 | |||
| P10493 | Nidogen-1 [OS=Mus musculus] | 275.191 | 43 | 42 | 852 | 42 | 1245 | 136.5 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | other molecular function | 18073 | ENSMUSG00000005397 | Nid1 | mmu:18073; P10493; Q3TKX9; Q8BQI3; Q8C3U8; Q8C9P6 | Laminin interactions; Degradation of the extracellular matrix | 20 | 20 | 12.26 | 6.185 | 0.272 | 1.009 | 0.083 | 3.135 | 1.65082956259427E-17 | 1.8644578313253E-17 | 0.251140212279038 | 0.461941385639594 | 0.013229256333524 | 0.604382524464811 | 1.0740690550749E-5 | 0.781368126060588 | 439897.722361698 | 266111.080129006 | 261357.080833752 | 1.30583493944604E8 | 1.41493313555848E8 | 1.08068734992402E8 | 1.1764867041349E8 | 1.23903817347262E8 | 1.22059347123012E8 | 3.85653673006923E7 | 3.40794335543811E7 | 2.32700802472122E7 | 8950100.03941293 | 6809358.71273179 | 1.16807558295498E7 | |
| O88207 | Collagen alpha-1(V) chain [OS=Mus musculus] | 275.025 | 46 | 52 | 413 | 44 | 1838 | 183.6 | cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes | extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12831 | ENSMUSG00000026837 | Col5a1 | A3KGE3; mmu:12831; O88207; Q3UG94; Q6F6B0 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | ECM proteoglycans; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; MET activates PTK2 signaling | 20 | 20 | 11.658 | 8.419 | 0.482 | 2.145 | 0.446 | 1.84 | 1.65082956259427E-17 | 1.8644578313253E-17 | 0.268653947705267 | 0.311207075116757 | 0.189625712887896 | 0.848119069115724 | 0.302671730722046 | 0.809503222445875 | 12502.6007438316 | 105962.872602761 | 122701.039249758 | 8585864.47184676 | 9052435.86465399 | 8047799.6262338 | 3715509.90739661 | 3183478.03245453 | 3834509.14396516 | 3548034.64380386 | 3694879.64301103 | 2052789.86607006 | 1322438.93167649 | 910135.702053452 | 1926767.56075777 |
| P37889 | Fibulin-2 [OS=Mus musculus] | 269.894 | 43 | 37 | 791 | 37 | 1221 | 131.7 | other biological processes | non-structural extracellular | other molecular function | 14115 | ENSMUSG00000064080 | Fbln2 | G5E8B3; mmu:14115; P37889; Q9WUI2 | Molecules associated with elastic fibres | 20 | 9.095 | 14.207 | 9.595 | 0.657 | 1.229 | 0.44 | 1.856 | 1.65082956259427E-17 | 0.0640195441309023 | 0.201227492083465 | 0.255240026777032 | 0.453005417011507 | 0.803447472095846 | 0.290132264062119 | 0.809503222445875 | 404936.27628206 | 303410.824570497 | 379728.902265123 | 7.35240092421165E7 | 8.16716617206073E7 | 8.54486063918813E7 | 7.34239875271171E7 | 6.18846762513378E7 | 6.13955038440774E7 | 5.64407337496573E7 | 5.35180097543675E7 | 3.80873889057723E7 | 2.96696416762988E7 | 2.21115750486307E7 | 3.84218730879294E7 | |
| Q8VHX6 | Filamin-C [OS=Mus musculus] | 249.498 | 31 | 65 | 425 | 56 | 2726 | 290.9 | cell organization and biogenesis;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity | 68794 | ENSMUSG00000068699 | Flnc | B2RY80; B9EKT2; mmu:68794; Q6PAI6; Q8VHX6; Q9JJ38 | Cell-extracellular matrix interactions | 0.924 | 1.063 | 2.364 | 0.915 | 1.621 | 1.781 | 0.941 | 3.029 | 0.562594032195739 | 0.719627996749639 | 0.962331548063155 | 0.57290809187594 | 0.976873891151678 | 0.96786708205164 | 0.933437821008547 | 0.80954066750699 | 362673.376414211 | 453714.7830589 | 401875.758519269 | 2896613.16388353 | 1997446.07055639 | 1374740.24453431 | 898320.393102247 | 899851.262035181 | 1251187.76236098 | 4619845.64928082 | 4224920.76413233 | 4533386.9985568 | 889222.28002913 | 1245417.60281572 | 1275359.84004796 | |
| Q04857 | Collagen alpha-1(VI) chain [OS=Mus musculus] | 248.981 | 44 | 33 | 588 | 33 | 1025 | 108.4 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component | other molecular function | 12833 | ENSMUSG00000001119 | Col6a1 | mmu:12833; Q04857 | ECM proteoglycans; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Signaling by PDGF; NCAM1 interactions | 8.793 | 4.087 | 2.364 | 2.258 | 0.328 | 1.748 | 0.341 | 1.364 | 0.2534363617947 | 0.392208211277376 | 0.962331548063155 | 0.971216996811237 | 0.0353343473113635 | 0.97504218639442 | 0.115965329440656 | 0.380888676065133 | 99442.7570537982 | 67304.0023261046 | 63848.8638629308 | 6.50338448192604E7 | 8.11264443817216E7 | 6.12675161034549E7 | 5.28406132873544E7 | 4.53711044962942E7 | 5.19951028566589E7 | 2.08305860584001E7 | 2.24322225654869E7 | 1.63957751491443E7 | 1.39653990737858E7 | 1.00181099527419E7 | 1.94360212112643E7 | |
| Cont_Q2UVX4 | Complement C3 OS=Bos taurus OX=9913 GN=C3 PE=1 SV=2 | 247.154 | 39 | 55 | 851 | 47 | 1661 | 187.1 | cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular;other cell component | signal transduction activity or receptor binding;enzyme regulator activity | 280677 | ENSBTAG00000017280 | C3 | bta:280677; Q2KIZ4; Q2UVX4 | Complement and coagulation cascades; Complement activation, classical pathway | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Neutrophil degranulation; Peptide ligand-binding receptors; G alpha (i) signalling events; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade; Alternative complement activation; Activation of C3 and C5 | 1.019 | 1.197 | 1.097 | 0.804 | 1.068 | 0.796 | 0.594 | 1.431 | 0.615680953989958 | 0.798729234704005 | 0.573945385766997 | 0.506364847510615 | 0.87421335771164 | 0.291700662163587 | 0.591028379533681 | 0.448532796991499 | 1.66248121121728E7 | 1.69271139045693E7 | 1.05083515570206E7 | 1.25526666866144E7 | 1.76991579704635E7 | 1.56235874907449E7 | 1.80944158276855E7 | 1.82336027421103E7 | 1.90370193770683E7 | 1.87583360164926E7 | 1.78001813666833E7 | 1.18248646641963E7 | 8899645.14317005 | 9025681.5960692 | 1.79617171787325E7 |
| Q62261 | Spectrin beta chain, non-erythrocytic 1 [OS=Mus musculus] | 244.684 | 30 | 61 | 398 | 61 | 2363 | 274.1 | cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 20742 | ENSMUSG00000020315 | Sptbn1 | A2AFU1; mmu:20742; Q3TEM7; Q5SQL8; Q5SQL9; Q62261; Q9QWJ7 | COPI-mediated anterograde transport; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; RHOU GTPase cycle; Interaction between L1 and Ankyrins; RHOV GTPase cycle | 1.181 | 1.156 | 1.412 | 1.471 | 1.95 | 2.087 | 1.904 | 2.22 | 0.69394578118832 | 0.776437620310661 | 0.693719649766064 | 0.831411077141515 | 0.937876734191067 | 0.86315143463057 | 0.664971370235365 | 0.953305976192702 | 373834.445440549 | 533726.562973047 | 569801.107945045 | 3103526.47805657 | 3181731.16602619 | 2477755.42998989 | 796281.087102098 | 609431.872132576 | 1356947.15467432 | 7745784.08821259 | 6610112.71623617 | 4897418.35730506 | 2432765.02616441 | 1743474.26371724 | 2723698.32906552 | |
| Q640N1 | Adipocyte enhancer-binding protein 1 [OS=Mus musculus] | 239.707 | 38 | 34 | 648 | 34 | 1128 | 128.3 | protein metabolism;other biological processes | nucleus;other cell component | nucleic acid binding activity;other molecular function | 11568 | ENSMUSG00000020473 | Aebp1 | mmu:11568; O88442; Q3TVV5; Q3TWA7; Q3TX56; Q3TXB2; Q5NCI9; Q61281; Q640N1 | 8.459 | 10.223 | 5.53 | 4.478 | 0.703 | 1.165 | 0.36 | 2.258 | 0.269326617826563 | 0.0457359864845759 | 0.605387748357992 | 0.631359014803774 | 0.534291750451691 | 0.760992448481534 | 0.145805028390539 | 0.963436677882021 | 3560033.84712119 | 4696620.34449178 | 6275149.80645163 | 4.59930845855363E7 | 5.69735867783534E7 | 2.04646374454636E7 | 3.80233154774145E7 | 4.02615711999708E7 | 4.03854487434811E7 | 3.40966164303398E7 | 3.7490792004469E7 | 2.41166240785119E7 | 1.4983671743246E7 | 1.40971982755857E7 | 2.68643149803103E7 | ||
| P57780 | Alpha-actinin-4 [OS=Mus musculus] | 239.42 | 58 | 45 | 483 | 30 | 912 | 104.9 | cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes | cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 60595 | ENSMUSG00000054808 | Actn4 | mmu:60595; P57780 | Primary focal segmental glomerulosclerosis (FSGS) | Platelet degranulation | 20 | 20 | 20 | 11.478 | 1.18 | 2.264 | 1.041 | 2.59 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 0.19149089837131 | 0.921882153462399 | 0.795351011232032 | 0.968364585136618 | 0.938282411159324 | 5221.79731213346 | 36578.541519335 | 9107610.67207618 | 1.00453975465233E7 | 1.03378326393571E7 | 5095419.11923033 | 3409382.50707632 | 5238186.41277381 | 1.31020350186557E7 | 1.2711162036506E7 | 9162046.18669404 | 4501757.36231035 | 3002316.05426355 | 5816939.08777499 | |
| Q7TPR4 | Alpha-actinin-1 [OS=Mus musculus] | 235.529 | 54 | 42 | 511 | 27 | 892 | 103 | cell adhesion;cell organization and biogenesis;other biological processes | plasma membrane;other membranes;cytoskeleton;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function | 109711 | ENSMUSG00000015143 | Actn1 | mmu:109711; Q7TPR4 | Regulation of actin cytoskeleton; Integrin-mediated cell adhesion; Focal adhesion | Platelet degranulation ; RHOF GTPase cycle; RHOBTB2 GTPase cycle; RHOD GTPase cycle; Regulation of cytoskeletal remodeling and cell spreading by IPP complex components | 2.068 | 0.45 | 1.822 | 2.422 | 1.639 | 2.396 | 1.586 | 2.793 | 0.995554138371554 | 0.178726136005694 | 0.819280225722906 | 0.941696908693733 | 0.974207409660283 | 0.744084716394381 | 0.837231569641376 | 0.879972045955715 | 354073.059499792 | 209249.076355465 | 897084.460899514 | 5526121.35104279 | 6211867.70337129 | 6893436.45630869 | 2413615.48536692 | 1933168.81934458 | 3229981.90899851 | 1.03807818109957E7 | 1.11771340173328E7 | 8282960.99949337 | 3416305.89125481 | 2797115.44078374 | 4939050.64701654 |
| P02468 | Laminin subunit gamma-1 [OS=Mus musculus] | 230.882 | 35 | 43 | 454 | 43 | 1607 | 177.2 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | Lamc1 | P02468 | 13.572 | 7.288 | 7.506 | 4.094 | 0.559 | 2.029 | 0.482 | 2.135 | 0.118212047511996 | 0.116315527815218 | 0.459134305737471 | 0.675951294045723 | 0.3041568870489 | 0.877818946381645 | 0.368062651583427 | 0.922276466908065 | 14325.5972836352 | 21883.5466161272 | 1.5357350900924E7 | 1.57310961044729E7 | 1.74335709018572E7 | 7496762.71625721 | 6775968.90045745 | 7708775.93718172 | 9245241.37337628 | 9035989.05815721 | 5573559.97495901 | 2765122.91380764 | 2368540.67041914 | 4605215.17131646 | |||||
| Q91ZX7 | Prolow-density lipoprotein receptor-related protein 1 [OS=Mus musculus] | 230.497 | 15 | 57 | 519 | 56 | 4545 | 504.4 | other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;other molecular function | 16971 | Lrp1 | mmu:16971; Q61291; Q91ZX7; Q920Y4 | Statin pathway; Wnt signaling pathway | Scavenging of heme from plasma; Retinoid metabolism and transport | 20 | 13.648 | 18.208 | 13.235 | 0.805 | 1.902 | 0.692 | 2.078 | 1.65082956259427E-17 | 0.0181625429641231 | 0.133639440745791 | 0.150830220548111 | 0.687557067265551 | 0.925871264502428 | 0.74148782464906 | 0.901098484497789 | 10237.2255539891 | 51104.3489937616 | 6875342.47952318 | 6944806.90573824 | 8247481.69257335 | 4299652.1243919 | 2953538.60705284 | 3392031.85738558 | 6405748.2654286 | 5854087.4911046 | 4914685.84613499 | 2044471.2247951 | 1705219.62694462 | 2981142.11204421 | ||
| Cont_P60712 | Actin, cytoplasmic 1 OS=Bos taurus OX=9913 GN=ACTB PE=1 SV=1 | 225.45 | 70 | 19 | 852 | 2 | 375 | 41.7 | cell organization and biogenesis;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component | enzyme regulator activity;cytoskeletal activity;other molecular function | 100033878; 100135470; 100173832; 101844587; 102139853; 11461; 118833809; 280979; 396526; 403580; 414396; 443052; 450133; 60; 81822 | ENSBTAG00000026199; ENSCAFG00000016020; ENSCAFG00030015381; ENSCAFG00040015695; ENSCPOG00000013467; ENSG00000075624; ENSMAUG00000008763; ENSMUSG00000029580; ENSOARG00040012985; ENSOARG00180022443; ENSOARG00185023855; ENSOARG00215030140; ENSOARG00225009314; ENSPPYG00000017336; ENSPTRG00000018890; ENSRNOG00000034254; ENSSSCG00000007585; ENSSSCG00030003451; ENSSSCG00035038792; ENSSSCG00040049462; ENSSSCG00045027458; ENSSSCG00050065025; ENSSSCG00055012597; ENSSSCG00060019124; ENSSSCG00065037921; ENSSSCG00070011353; ENSSSCG00105030144; ENSSSCG00110026965; ENSSSCG00115013637; ENSSSCG00130033784 | Actb; ACTB | A5D961; A5PKA1; bta:280979; cfa:403580; cpoc:100135470; csab:103246953; ecb:100033878; gga:396526; hsa:60; maua:101844587; mmu:11461; O18840; oas:443052; P02570; P60706; P60707; P60708; P60709; P60710; P60711; P60712; P60713; P70514; P99021; pon:100173832; ptr:450133; Q11209; Q11211; Q3SZD2; Q3TI89; Q3TVP6; Q4L0Y2; Q4R561; Q5R1X3; Q5R582; Q5R6G0; Q64316; Q6QAQ1; Q6ZWM3; Q711N9; Q71FK5; Q75MN2; Q76N69; Q8MIJ0; Q8SPX4; Q95164; Q96B34; Q96HG5; rno:81822; ssc:414396 | FAS pathway and stress induction of HSP regulation; Actin cytoskeleton regulation; Myometrial relaxation and contraction pathways; Focal adhesion; Arrhythmogenic right ventricular cardiomyopathy; Pathogenic Escherichia coli infection; Common pathways underlying drug addiction; Myometrial relaxation and contraction pathways; Focal adhesion; Fas ligand pathway and stress induction of heat shock proteins; Pathogenic Escherichia coli infection; Arrhythmogenic right ventricular cardiomyopathy; Focal adhesion; Myometrial relaxation and contraction pathways; Regulation of actin cytoskeleton; Myometrial relaxation and contraction pathways; Ebola virus infection in host; Acute viral myocarditis; Thermogenesis; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Overlap between signal transduction pathways contributing to LMNA laminopathies; Pleural mesothelioma; Regulation of actin cytoskeleton; Network map of SARS-CoV-2 signaling; Regulation of actin cytoskeleton; Regulation of actin cytoskeleton; Focal adhesion | Formation of the canonical BAF (cBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); Regulation of actin dynamics for phagocytic cup formation; EPH-ephrin mediated repulsion of cells; Formation of annular gap junctions; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; RHO GTPases Activate Formins; RHOF GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; B-WICH complex positively regulates rRNA expression; Regulation of CDH1 Function; Formation of the dystrophin-glycoprotein complex (DGC); Formation of the canonical BAF (cBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); RHO GTPases Activate WASPs and WAVEs; UCH proteinases; DNA Damage Recognition in GG-NER; Formation of the non-canonical BAF (ncBAF) complex; RHO GTPases activate IQGAPs; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Cell-extracellular matrix interactions; MAP2K and MAPK activation; Interaction between L1 and Ankyrins; RHOF GTPase cycle; DNA Damage Recognition in GG-NER; MAP2K and MAPK activation; RHO GTPases Activate Formins; Clathrin-mediated endocytosis; UCH proteinases; RHOF GTPase cycle; DNA Damage Recognition in GG-NER; EPH-ephrin mediated repulsion of cells; VEGFA-VEGFR2 Pathway; Regulation of actin dynamics for phagocytic cup formation; Adherens junctions interactions; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); RHO GTPases Activate WASPs and WAVEs; B-WICH complex positively regulates rRNA expression; Regulation of CDH1 Function; EPHB-mediated forward signaling; Formation of the non-canonical BAF (ncBAF) complex; Formation of the canonical BAF (cBAF) complex; Formation of annular gap junctions; RHO GTPases activate IQGAPs; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; RHO GTPases Activate WASPs and WAVEs; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RHO GTPases activate IQGAPs; RHO GTPases Activate Formins; RHOF GTPase cycle; Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs); B-WICH complex positively regulates rRNA expression; Signaling by BRAF and RAF1 fusions; UCH proteinases; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; VEGFA-VEGFR2 Pathway; Formation of the dystrophin-glycoprotein complex (DGC); Factors involved in megakaryocyte development and platelet production; Regulation of MITF-M-dependent genes involved in pigmentation; Formation of the canonical BAF (cBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); EPH-ephrin mediated repulsion of cells; HATs acetylate histones; Interaction between L1 and Ankyrins; Prefoldin mediated transfer of substrate to CCT/TriC; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Adherens junctions interactions; Regulation of CDH1 Function; Formation of the non-canonical BAF (ncBAF) complex; DNA Damage Recognition in GG-NER; Formation of the polybromo-BAF (pBAF) complex; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Formation of annular gap junctions; Folding of actin by CCT/TriC; Cell-extracellular matrix interactions; MAP2K and MAPK activation; RHO GTPases Activate Formins; Recycling pathway of L1; RHO GTPases activate IQGAPs; Clathrin-mediated endocytosis; Formation of the dystrophin-glycoprotein complex (DGC); EPHB-mediated forward signaling; UCH proteinases; B-WICH complex positively regulates rRNA expression; Adherens junctions interactions; Formation of the non-canonical BAF (ncBAF) complex; Formation of annular gap junctions; Formation of the polybromo-BAF (pBAF) complex; VEGFA-VEGFR2 Pathway; Cell-extracellular matrix interactions; RHO GTPases Activate WASPs and WAVEs; Regulation of CDH1 Function; Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; UCH proteinases; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); Formation of the polybromo-BAF (pBAF) complex; B-WICH complex positively regulates rRNA expression; DNA Damage Recognition in GG-NER; Formation of the canonical BAF (cBAF) complex; RHO GTPases Activate Formins; Regulation of CDH1 Function; Interaction between L1 and Ankyrins; RHOF GTPase cycle; Formation of the non-canonical BAF (ncBAF) complex; Adherens junctions interactions; Formation of the dystrophin-glycoprotein complex (DGC); VEGFA-VEGFR2 Pathway; RHO GTPases Activate WASPs and WAVEs; Cell-extracellular matrix interactions; EPHB-mediated forward signaling; MAP2K and MAPK activation; Recycling pathway of L1; RHO GTPases activate IQGAPs; Formation of annular gap junctions; B-WICH complex positively regulates rRNA expression; UCH proteinases; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); MAP2K and MAPK activation; Formation of the polybromo-BAF (pBAF) complex; RHO GTPases Activate Formins; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases Activate WASPs and WAVEs; Formation of the dystrophin-glycoprotein complex (DGC); VEGFA-VEGFR2 Pathway; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; DNA Damage Recognition in GG-NER; RHOF GTPase cycle; Cell-extracellular matrix interactions; Adherens junctions interactions; Formation of the non-canonical BAF (ncBAF) complex; Formation of the canonical BAF (cBAF) complex; RHO GTPases activate IQGAPs; Regulation of CDH1 Function; Gap junction degradation; Formation of annular gap junctions; Regulation of actin dynamics for phagocytic cup formation; RHOF GTPase cycle; Clathrin-mediated endocytosis; RHO GTPases Activate Formins; Cell-extracellular matrix interactions; VEGFA-VEGFR2 Pathway; Adherens junctions interactions; RHO GTPases activate IQGAPs; UCH proteinases; EPHB-mediated forward signaling; MAP2K and MAPK activation; RHO GTPases Activate WASPs and WAVEs; Formation of the dystrophin-glycoprotein complex (DGC); Formation of annular gap junctions; Formation of the canonical BAF (cBAF) complex; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of the non-canonical BAF (ncBAF) complex; Regulation of CDH1 Function | 20 | 20 | 20 | 20 | 1.785 | 1.645 | 1.193 | 2.594 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.946568086066385 | 0.994348552930242 | 0.963278515868644 | 0.938282411159324 | 1924782.99006244 | 2098949.09709163 | 1966246.27612296 | 6.9333476629433E7 | 7.92679608662888E7 | 4.66219167617927E7 | 4.31411746831055E7 | 4.48147974340301E7 | 5.69102455002969E7 | 1.21577893646273E8 | 1.207324829685E8 | 8.72162161647777E7 | 5.58171302270344E7 | 3.75040107769213E7 | 6.67519874410893E7 |
| P63260 | Actin, cytoplasmic 2 [OS=Mus musculus] | 217.791 | 70 | 19 | 831 | 2 | 375 | 41.8 | cell organization and biogenesis;stress response;developmental processes;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 11465 | ENSMUSG00000062825 | Actg1 | mmu:11465; P02571; P14104; P63260; P99022 | Myometrial relaxation and contraction pathways; Regulation of actin cytoskeleton; Focal adhesion | Platelet degranulation ; RHO GTPases activate IQGAPs; Adherens junctions interactions; Regulation of CDH1 Function; RHO GTPases Activate Formins; Regulation of actin dynamics for phagocytic cup formation; Interaction between L1 and Ankyrins; MAP2K and MAPK activation; Recycling pathway of L1; Clathrin-mediated endocytosis; Formation of the dystrophin-glycoprotein complex (DGC); EPHB-mediated forward signaling; RHOF GTPase cycle; Formation of annular gap junctions; VEGFA-VEGFR2 Pathway; Cell-extracellular matrix interactions; RHO GTPases Activate WASPs and WAVEs; RHOBTB2 GTPase cycle | 20 | 20 | 20 | 20 | 1 | 1.401 | 0.685 | 1.853 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.85271451854395 | 0.901789796153066 | 0.731487178650893 | 0.819844267712751 | 345218.530665522 | 243712.893345201 | 175067.879334021 | 138179.400499307 | 114235.784978709 | 184680.44906409 | 283414.957020267 | 357431.419092683 | 129167.257177683 | 191405.076269325 | 47386.9835565671 | 139954.449837086 | |||
| P33434 | 72 kDa type IV collagenase [OS=Mus musculus] | 212.03 | 56 | 30 | 889 | 30 | 662 | 74.1 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes | extracellular matrix;plasma membrane;other membranes;cytoskeleton;mitochondrion;nucleus;other cell component | other molecular function | 17390 | ENSMUSG00000031740 | Mmp2 | mmu:17390; P33434 | Lung fibrosis; IL-3 signaling pathway; Matrix metalloproteinases | Collagen degradation; Extra-nuclear estrogen signaling; EPH-ephrin mediated repulsion of cells; Activation of Matrix Metalloproteinases | 6.722 | 1.555 | 9.726 | 3.89 | 1.512 | 3.012 | 2.621 | 1.842 | 0.372996577396536 | 0.964209443670126 | 0.342075680986172 | 0.708142491896103 | 0.993994198406889 | 0.459747209584207 | 0.34519376377552 | 0.809503222445875 | 1.45817945044039E7 | 3.99854546791863E7 | 2.31586213408419E7 | 6.16168347215595E7 | 6.71128653428481E7 | 5.47627512450794E7 | 2.153095933586E7 | 2.04088973517033E7 | 2.1514079157928E7 | 9.59427020238632E7 | 8.49468673692442E7 | 8.11217362792938E7 | 5.65046943814106E7 | 3.5725700482165E7 | 6.85636819548367E7 |
| P19096 | Fatty acid synthase [OS=Mus musculus] | 203.372 | 23 | 48 | 335 | 48 | 2504 | 272.3 | other metabolic processes;stress response;other biological processes | plasma membrane;other membranes;cytosol;ER/Golgi;other cell component | other molecular function | 14104 | ENSMUSG00000025153 | Fasn | B1ATU8; mmu:14104; P19096; Q6PB72; Q8C4Z0; Q9EQR0 | Fatty acid biosynthesis; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-9 fatty acid synthesis; Elongation of (very) long chain fatty acids | Fatty acyl-CoA biosynthesis; Vitamin B5 (pantothenate) metabolism | 3.919 | 2.111 | 2.319 | 4.668 | 1.067 | 1.669 | 0.698 | 2.417 | 0.66189768147619 | 0.847457711018997 | 0.951921622352553 | 0.605074788683686 | 0.87421335771164 | 0.994834213681465 | 0.746782404466558 | 0.990873516209569 | 48161.514825801 | 157425.136778521 | 3018838.26514359 | 3331564.42510829 | 1838171.31939824 | 1125050.80259593 | 1067574.24276956 | 1976727.22395058 | 3354008.01034064 | 3348654.9716265 | 2283763.91979924 | 908323.020723558 | 618361.207888453 | 1151575.74161029 | |
| Cont_Q3SZ57 | Alpha-fetoprotein OS=Bos taurus OX=9913 GN=AFP PE=2 SV=1 | 202.89 | 62 | 30 | 1153 | 29 | 610 | 68.5 | other metabolic processes;developmental processes;other biological processes | non-structural extracellular;other cell component | other molecular function | 506011 | ENSBTAG00000017131 | AFP | bta:506011; Q3SZ57 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 0.89 | 1.253 | 1.171 | 0.883 | 1.251 | 0.689 | 0.666 | 1.305 | 0.540832988168188 | 0.82964085881652 | 0.605387748357992 | 0.553772240900005 | 0.938859506774495 | 0.15729598575093 | 0.699570390946254 | 0.323545662226049 | 4.4629857016799E7 | 4.39639700572647E7 | 2.72178105183923E7 | 3.15168703669999E7 | 4.26075077823651E7 | 3.4328683389093E7 | 4.8541823037709E7 | 4.32960721364381E7 | 4.4115949306695E7 | 4.61564880446121E7 | 4.7548077639711E7 | 3.504265434565E7 | 2.7823391939759E7 | 3.01476017178829E7 | 5.24042356620578E7 | |
| P48678 | Prelamin-A/C [OS=Mus musculus] | 202.607 | 60 | 37 | 529 | 36 | 665 | 74.2 | cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes | other membranes;cytoskeleton;nucleus;other cell component | other molecular function | 16905 | ENSMUSG00000028063 | Lmna | B3RH23; B3RH24; mmu:16905; P11516; P48678; P97859; Q3TIH0; Q3TTS8; Q3U733; Q3U7I5; Q3UCA0; Q3UCJ8; Q3UCU3; Q91WF2; Q9DC21 | Adipogenesis genes; FAS pathway and stress induction of HSP regulation | 20 | 17.997 | 17.767 | 20 | 4.584 | 2.32 | 1.381 | 7.656 | 1.65082956259427E-17 | 0.00670345592293191 | 0.139423967594304 | 1.70336894001643E-17 | 0.236076921565588 | 0.77212820363828 | 0.901149690306505 | 0.00692305873191716 | 56886.7483713492 | 69336.1384695612 | 100943.444664856 | 1.29312831685903E7 | 1.22006597313063E7 | 8045013.512583 | 3337288.2268023 | 3262868.75019265 | 5804803.63611667 | 6.75536277126862E7 | 5.59333072922179E7 | 3.75993669940438E7 | 7422846.33935557 | 4234323.21548912 | 7210898.93259597 | |
| Q02788 | Collagen alpha-2(VI) chain [OS=Mus musculus] | 202.37 | 41 | 36 | 585 | 36 | 1034 | 110.3 | cell adhesion;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component | other molecular function | 12834 | ENSMUSG00000020241 | Col6a2 | mmu:12834; Q02788; Q05505; Q8C972; Q8K229 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | ECM proteoglycans; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation | 10.956 | 20 | 5.246 | 3.501 | 0.458 | 1.362 | 0.325 | 1.848 | 0.175734701097799 | 1.8644578313253E-17 | 0.633123216104285 | 0.767312384697355 | 0.156641881403766 | 0.880899056945259 | 0.0961283818482991 | 0.809503222445875 | 66343.4096791777 | 224638.480326659 | 72730.0086108415 | 5.06665581594054E7 | 6.05623117299827E7 | 4.51585075606234E7 | 4.3575871784427E7 | 3.72580130101725E7 | 4.32608904810994E7 | 2.4375983761655E7 | 2.22548052919965E7 | 1.51565723805374E7 | 1.09937351728106E7 | 7758608.50160191 | 1.64425759910943E7 |
| P97927 | Laminin subunit alpha-4 [OS=Mus musculus] | 199.33 | 30 | 41 | 409 | 41 | 1816 | 201.7 | cell adhesion;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | signal transduction activity or receptor binding | 16775 | ENSMUSG00000019846 | Lama4 | mmu:16775; O88785; P70409; P97927; Q14BF2 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Formation of the dystrophin-glycoprotein complex (DGC); Laminin interactions; MET activates PTK2 signaling | 5.298 | 2.886 | 2.789 | 3.143 | 0.574 | 1.89 | 0.55 | 1.892 | 0.496649188935323 | 0.645007535999596 | 0.952104483873957 | 0.825047045401531 | 0.329011090732691 | 0.929291541980042 | 0.50594120050135 | 0.819844267712751 | 540030.170801593 | 370746.050286439 | 259459.878107817 | 8261193.64464048 | 1.06712284071143E7 | 1.21929154576081E7 | 5309597.35327991 | 4688186.1422195 | 5379156.74886131 | 6459712.32980478 | 5951943.81149588 | 4870147.4483696 | 2541823.46940274 | 2775962.47504545 | 3878847.28463652 |
| P20152 | Vimentin [OS=Mus musculus] | 183.446 | 60 | 29 | 762 | 27 | 466 | 53.7 | cell organization and biogenesis;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component | cytoskeletal activity;nucleic acid binding activity;other molecular function | 22352 | ENSMUSG00000026728 | Vim | mmu:22352; O08704; P20152; Q8CCH1 | Spinal cord injury; Primary focal segmental glomerulosclerosis (FSGS); Alpha 6 beta 4 integrin signaling pathway | Aggrephagy; Striated Muscle Contraction; Caspase-mediated cleavage of cytoskeletal proteins; RHOBTB1 GTPase cycle | 20 | 7.872 | 20 | 13.938 | 2.257 | 5.309 | 1.573 | 6.359 | 1.65082956259427E-17 | 0.0955146622024883 | 1.50457038391225E-17 | 0.137621774180062 | 0.873609880131656 | 0.0297998664849654 | 0.840672080806375 | 0.0332723373064956 | 573727.34417641 | 968981.536762911 | 1794707.43115169 | 4.14069582585024E7 | 3.33312643886138E7 | 2.54656192896882E7 | 6941733.99810384 | 6173483.46835617 | 8980531.63051753 | 8.80704815958352E7 | 8.07026224155391E7 | 5.51524218564722E7 | 1.5029979690535E7 | 6861556.37440952 | 1.68923991921504E7 |
| Q64727 | Vinculin [OS=Mus musculus] | 182.753 | 50 | 45 | 419 | 45 | 1066 | 116.6 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | plasma membrane;other membranes;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 22330 | ENSMUSG00000021823 | Vcl | mmu:22330; Q64727; Q8BP32; Q8BS46; Q922C5; Q922D9 | Primary focal segmental glomerulosclerosis (FSGS); IL-3 signaling pathway; Regulation of actin cytoskeleton; Integrin-mediated cell adhesion; Focal adhesion | Neutrophil degranulation; High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells; Platelet degranulation ; MAP2K and MAPK activation; Smooth Muscle Contraction; Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells; Regulation of CDH1 Function | 9.889 | 5.909 | 12.691 | 5.698 | 1.39 | 2.026 | 1.158 | 2.519 | 0.208404050858596 | 0.190838415616571 | 0.238791978742132 | 0.504745711776551 | 0.964629994744883 | 0.878264980963866 | 0.977491813528386 | 0.958518237573655 | 199164.849916128 | 87100.0128702587 | 92185.322880836 | 5675245.0989599 | 5838625.66584249 | 3008640.49360623 | 1870082.63283096 | 1414114.90526218 | 2577750.73562883 | 7844023.43396073 | 7226639.25078312 | 5204108.91618431 | 2343388.9049214 | 1587883.53032107 | 3146179.30802337 |
| Q8K4G1 | Latent-transforming growth factor beta-binding protein 4 [OS=Mus musculus] | 180.216 | 27 | 29 | 318 | 29 | 1666 | 178.5 | cell-cell signaling;cell organization and biogenesis;transport;signal transduction | non-structural extracellular;extracellular matrix | other molecular function | 108075 | ENSMUSG00000040488 | Ltbp4 | E9QPD9; mmu:108075; Q8K4G0; Q8K4G1 | TGF-beta receptor signaling activates SMADs; Molecules associated with elastic fibres | 7.729 | 4.292 | 20 | 12.27 | 2.67 | 1.52 | 1.837 | 2.119 | 0.308350896322176 | 0.362779483059131 | 1.50457038391225E-17 | 0.170566190602959 | 0.775297640004946 | 0.958956615096849 | 0.703189639676216 | 0.915193515309545 | 20541.0495723262 | 79596.1275426221 | 2657106.34177438 | 3398147.96764637 | 1365787.73467607 | 1578272.63307431 | 1205878.60177515 | 1625778.79640944 | 7998382.13678965 | 8274900.61088866 | 5600614.51816097 | 3209012.09868788 | 1154237.54308251 | 3609675.59166937 | ||
| Q68FD5 | Clathrin heavy chain 1 [OS=Mus musculus] | 180.117 | 32 | 43 | 363 | 43 | 1675 | 191.4 | cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes | plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component | nucleic acid binding activity;other molecular function | 67300 | ENSMUSG00000047126 | Cltc | mmu:67300; Q68FD5 | IL-7 signaling pathway; Kit receptor signaling pathway | MHC class II antigen presentation; Recycling pathway of L1; Cargo recognition for clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis; LDL clearance; Retrograde neurotrophin signalling; Formation of annular gap junctions; Lysosome Vesicle Biogenesis; WNT5A-dependent internalization of FZD4; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation; RHOU GTPase cycle; RHOV GTPase cycle | 6.05 | 5.808 | 20 | 6.768 | 2.931 | 1.275 | 1.251 | 2.935 | 0.4248536990637 | 0.198232028950426 | 1.50457038391225E-17 | 0.413413145615294 | 0.688274955487563 | 0.840666598828607 | 0.946476383814868 | 0.835383236382767 | 19752.350121194 | 9410.067942265 | 2001079.20697008 | 2709198.63758679 | 1592899.41627153 | 1121542.74388673 | 1205380.43272811 | 1952895.490984 | 7620271.96644723 | 6531411.29627789 | 6339405.19264676 | 2211269.42731124 | 1288866.59437226 | 2734753.66820203 | |
| P02469 | Laminin subunit beta-1 [OS=Mus musculus] | 179.863 | 27 | 40 | 429 | 39 | 1786 | 197 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;nucleus;other cell component | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 16777 | ENSMUSG00000002900 | Lamb1 | E9PXZ9; P02469 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Inflammatory response pathway; Alpha 6 beta 4 integrin signaling pathway; Focal adhesion | 9.979 | 4.434 | 6.526 | 2.693 | 0.537 | 1.97 | 0.475 | 2.435 | 0.205801242418232 | 0.341417478664423 | 0.526489846375643 | 0.891178501081124 | 0.269583968882479 | 0.900334730044572 | 0.356773085915651 | 0.98779298590131 | 1.07332672254E7 | 1.09845016908001E7 | 9663847.07936098 | 1.70142446901215E7 | 1.73820787777271E7 | 2.08268192848537E7 | 1.23074043806854E7 | 1.3842748821146E7 | 1.68288599063313E7 | 1.20697658178524E7 | 1.33872705970957E7 | 9031275.37365186 | 2.12878061302996E7 | 2.54341447554609E7 | 1.6513199650281E7 | |
| Q01853 | Transitional endoplasmic reticulum ATPase [OS=Mus musculus] | 179.055 | 52 | 32 | 411 | 32 | 806 | 89.3 | cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;other biological processes | other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;enzyme regulator activity;other molecular function | 269523 | ENSMUSG00000028452 | Vcp | mmu:269523; Q01853; Q3TFH9; Q3TIM2; Q3TXN9; Q6PI18; Q8BSR6; Q8CEG4 | IL-9 signaling pathway | RHOH GTPase cycle; Neutrophil degranulation; Protein methylation; Ovarian tumor domain proteases; Neddylation; ABC-family proteins mediated transport; Translesion Synthesis by POLH; Hedgehog ligand biogenesis; KEAP1-NFE2L2 pathway; HSF1 activation; N-glycan trimming in the ER and Calnexin/Calreticulin cycle; Josephin domain DUBs | 1.775 | 2.885 | 1.782 | 1.945 | 1.345 | 2.036 | 0.893 | 3.238 | 0.915230778358139 | 0.645007535999596 | 0.808626104853287 | 0.953867932777128 | 0.953038161729767 | 0.877818946381645 | 0.901149690306505 | 0.737824045087029 | 462345.280919521 | 876653.458620268 | 526426.850526767 | 1.01571081063743E7 | 9889323.38925712 | 7942233.31155878 | 4702185.44070802 | 4580279.55870278 | 6732778.24078372 | 1.50535993864462E7 | 1.350776734351E7 | 9751498.62422888 | 4128956.06599177 | 3881002.94215154 | 5380991.32313934 |
| Q03350 | Thrombospondin-2 [OS=Mus musculus] | 178.303 | 35 | 30 | 328 | 29 | 1172 | 129.8 | cell adhesion;other biological processes | non-structural extracellular;extracellular matrix;other cell component | other molecular function | 21826 | ENSMUSG00000023885 | Thbs2 | mmu:21826; Q03350; Q8CG21 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Signaling by PDGF; O-glycosylation of TSR domain-containing proteins | 0.722 | 1.325 | 0.917 | 0.852 | 0.905 | 1.968 | 0.612 | 3.033 | 0.425958502904743 | 0.861805134687803 | 0.49027994509233 | 0.535702081245677 | 0.792896707923278 | 0.900334730044572 | 0.620448351319483 | 0.80954066750699 | 2258622.92192986 | 2382783.54746756 | 1148078.18193404 | 1.31796330485542E7 | 1.5104624453426E7 | 5024405.63191042 | 7531099.32555027 | 7013388.1367688 | 7773703.92822199 | 1.11743686938308E7 | 1.16923792648853E7 | 8892616.7561804 | 4798999.04450137 | 2163159.37338424 | 5673668.48605754 |
| Q80YX1 | Tenascin [OS=Mus musculus] | 175.9 | 28 | 43 | 191 | 43 | 2110 | 231.7 | cell adhesion;cell-cell signaling;cell organization and biogenesis;stress response;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | signal transduction activity or receptor binding;other molecular function | 21923 | ENSMUSG00000028364 | Tnc | mmu:21923; Q64706; Q80YX1; Q80YX2 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Integrin cell surface interactions; ECM proteoglycans; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 13.594 | 2.194 | 1.128 | 0.769 | 0.051 | 7.209 | 0.207 | 1.299 | 0.117980756369098 | 0.827773046590747 | 0.560799429150649 | 0.474732236495646 | 1.08858887903907E-8 | 0.00280630917527262 | 0.00972980877962454 | 0.46732263590517 | 11007.0641239407 | 22426.4186578027 | 29153.7668969926 | 1.62969685459921E7 | 1.53776908456905E7 | 4644794.12302626 | 1608421.63729791 | 1232799.46655266 | 1507622.18059477 | 244493.865771831 | 206768.885305398 | 181767.385360463 | 119126.026959952 | 48104.5148614081 | 121500.029653831 |
| Q61147 | Ceruloplasmin [OS=Mus musculus] | 175.43 | 36 | 33 | 380 | 33 | 1061 | 121.1 | cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular | other molecular function | 12870 | ENSMUSG00000003617 | Cp | mmu:12870; Q61147; Q6P5C8 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Iron uptake and transport; Metal ion SLC transporters | 20 | 11.915 | 12.922 | 6.069 | 0.422 | 1.96 | 0.402 | 1.911 | 1.65082956259427E-17 | 0.0286042496128814 | 0.232756100865398 | 0.470567140616547 | 0.114472406028442 | 0.902824569867946 | 0.217345018530886 | 0.830251457557488 | 174325.913751449 | 58856.3090021062 | 115033.849364799 | 9557281.19120236 | 1.04767827169696E7 | 8762702.67228452 | 5461844.00566682 | 4018732.98956624 | 4629071.77649001 | 4355240.25919752 | 3723693.63350954 | 2684226.57769155 | 1556963.66647869 | 1720243.51649846 | 1992732.45731179 | |
| Q3UQ28 | Peroxidasin homolog [OS=Mus musculus] | 173.636 | 35 | 39 | 366 | 39 | 1475 | 165 | cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes | extracellular matrix;ER/Golgi;other cell component | extracellular structural activity;other molecular function | 69675 | ENSMUSG00000020674 | Pxdn | A4FU83; E9QNQ9; mmu:69675; Q3UQ28 | Crosslinking of collagen fibrils | 13.369 | 5.796 | 7.187 | 4.304 | 0.633 | 2.558 | 0.614 | 2.684 | 0.121749369203589 | 0.199060935853007 | 0.481687712882875 | 0.64860195920101 | 0.414844709855988 | 0.680311384167738 | 0.622521206052951 | 0.910753558746772 | 41306.9360165718 | 84058.3874627107 | 31201.070658041 | 9910595.89492489 | 1.28240532958945E7 | 7690537.3381544 | 3188445.14026578 | 3418561.86158515 | 3797799.58981602 | 6834484.53714744 | 5848987.74573488 | 4912888.48741006 | 1858779.55214279 | 743355.386480967 | 2642059.33003837 | |
| Q61316 | Heat shock 70 kDa protein 4 [OS=Mus musculus] | 169.044 | 48 | 31 | 300 | 31 | 841 | 94.1 | protein metabolism;other metabolic processes | other cell component | other molecular function | Hspa4 | Q61316 | Regulation of HSF1-mediated heat shock response | 3.829 | 1.513 | 4.49 | 1.286 | 1.217 | 1.907 | 0.903 | 2.909 | 0.675982462193546 | 0.947627746595709 | 0.704651587991194 | 0.760498481134506 | 0.937908804051419 | 0.922660568001848 | 0.905946265571965 | 0.842404289073844 | 22434.4697799145 | 118934.685179003 | 13120.5332518918 | 3090247.7626811 | 3632683.19217962 | 4934376.07998548 | 1752659.26658268 | 1094548.72984359 | 2299362.24833368 | 6254897.5603188 | 4282912.67963475 | 3832568.37667092 | 1209098.21921722 | 1139246.15986255 | 2002609.64313824 | |||
| Cont_P02533 | Keratin, type I cytoskeletal 14 OS=Homo sapiens OX=9606 GN=KRT14 PE=1 SV=4 | 164.831 | 58 | 26 | 684 | 9 | 472 | 51.5 | cell organization and biogenesis;other biological processes | plasma membrane;cytosol;cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 3861 | ENSG00000186847 | KRT14 | hsa:3861; P02533; Q14715; Q53XY3; Q9BUE3; Q9UBN2; Q9UBN3; Q9UCY4 | Corticotropin-releasing hormone signaling | Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin; Developmental Lineage of Mammary Gland Myoepithelial Cells; Type I hemidesmosome assembly | 1.494 | 1.366 | 1.328 | 2.74 | 0.843 | 1.136 | 1.961 | 0.518 | 0.821333803243143 | 0.880930298968675 | 0.666244110962191 | 0.887279041944908 | 0.735573385767802 | 0.728871118050286 | 0.645534074006669 | 1.76226512549596E-4 | 6033554.14310828 | 6671959.15781397 | 7782964.06135275 | 8837829.92566611 | 1.15627425945257E7 | 9278023.72116937 | 1.41062299354562E7 | 8950994.20838312 | 7841743.81261716 | 1.15454726530467E7 | 7260451.91646668 | 9574113.2223773 | 5.39893889957522E7 | 2.05703168301172E7 | 1.34402077310531E7 |
| P11499 | Heat shock protein HSP 90-beta [OS=Mus musculus] | 164.719 | 50 | 29 | 532 | 19 | 724 | 83.2 | cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component | enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function | 15516 | ENSMUSG00000023944 | Hsp90ab1 | mmu:15516; O89078; P11499; Q3UIQ7 | Focal adhesion: PI3K-Akt-mTOR signaling pathway | Neutrophil degranulation; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of actin dynamics for phagocytic cup formation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Attenuation phase; Estrogen-dependent gene expression; Sema3A PAK dependent Axon repulsion; Aryl hydrocarbon receptor signalling; DDX58/IFIH1-mediated induction of interferon-alpha/beta; HSF1 activation; RHOBTB2 GTPase cycle; The NLRP3 inflammasome | 20 | 20 | 20 | 20 | 1.344 | 3.198 | 1.054 | 3.873 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.952333191127893 | 0.385192173946943 | 0.975071223710592 | 0.476079393565723 | 221410.585638305 | 129165.68527882 | 147525.692220339 | 3.34627647115336E7 | 3.61961534999558E7 | 2.61391308788083E7 | 9541203.16877468 | 9273367.56835581 | 1.36082703259873E7 | 4.57710434253974E7 | 4.37708354854306E7 | 3.73056416942256E7 | 1.17622035416132E7 | 7437513.65495311 | 1.56244060515822E7 |
| Q9JKF1 | Ras GTPase-activating-like protein IQGAP1 [OS=Mus musculus] | 163.926 | 28 | 36 | 250 | 36 | 1657 | 188.6 | cell organization and biogenesis;developmental processes;signal transduction;other biological processes | plasma membrane;other membranes;cytoskeleton;nucleus;other cell component | enzyme regulator activity;other molecular function | 29875 | ENSMUSG00000030536 | Iqgap1 | G3UW45; mmu:29875; Q9JKF1 | G13 signaling pathway; Regulation of actin cytoskeleton | RHO GTPases activate IQGAPs; Neutrophil degranulation; RAC1 GTPase cycle; RAC2 GTPase cycle; RHOA GTPase cycle; MAP2K and MAPK activation; RHOQ GTPase cycle; RHOC GTPase cycle; RHOU GTPase cycle; RHOV GTPase cycle; Nephrin family interactions | 2.389 | 1.188 | 3.792 | 2.098 | 2.451 | 1.85 | 1.692 | 2.634 | 0.930229675308081 | 0.794460986683881 | 0.787568130909409 | 0.991639536226218 | 0.830676695521175 | 0.941920360687835 | 0.777195460870953 | 0.924682711624237 | 49243.316732893 | 68725.418758499 | 969026.209101501 | 1404075.03080168 | 833592.785314498 | 204266.486982725 | 334218.990287697 | 455010.844725875 | 4213732.69874793 | 3933999.53801573 | 3238797.72524118 | 860307.289081776 | 503563.00444482 | 1468565.36197421 | |
| P52480 | Pyruvate kinase PKM [OS=Mus musculus] | 163.393 | 62 | 27 | 442 | 27 | 531 | 57.8 | cell organization and biogenesis;other metabolic processes;other biological processes | cytosol;ER/Golgi;nucleus;other cell component | nucleic acid binding activity;kinase activity;other molecular function | 18746 | ENSMUSG00000032294 | Pkm | mmu:18746; P52480; Q3TBV8; Q3TBW5; Q3TC59; Q3U1X3; Q3U5P6; Q4VC20; Q64484; Q91YI8; Q9CWB1 | Glycolysis and gluconeogenesis; Purine metabolism | Neutrophil degranulation; Pyruvate metabolism; Glycolysis; Regulation of pyruvate metabolism | 20 | 20 | 20 | 20 | 1.91 | 1.562 | 1.218 | 2.517 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.938859506774495 | 0.972868731003358 | 0.958705855138011 | 0.959522188921769 | 312569.127047718 | 79336.1029165598 | 280190.614862653 | 2.13357824001936E7 | 1.96436562290884E7 | 9081648.29120601 | 1.01259485831113E7 | 9467201.29798786 | 1.55257573035923E7 | 3.31547939620584E7 | 3.43565739025104E7 | 2.75852274417617E7 | 1.43901632993649E7 | 7722776.69094361 | 1.86748082798887E7 |
| P63017 | Heat shock cognate 71 kDa protein [OS=Mus musculus] | 161.557 | 53 | 28 | 572 | 23 | 646 | 70.8 | cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component | signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function | 15481 | ENSMUSG00000015656 | Hspa8 | mmu:15481; P08109; P12225; P63017; Q3U6R0; Q3U764; Q3U7D7; Q3U7E2; Q3U9B4; Q3U9G0; Q3UGM0; Q5FWJ6; Q62373; Q62374; Q62375; Q6NZD0 | Mapk signaling pathway; Exercise-induced circadian regulation | Neutrophil degranulation; mRNA Splicing - Major Pathway; Regulation of HSF1-mediated heat shock response; PKR-mediated signaling; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis; Attenuation phase; Lysosome Vesicle Biogenesis; GABA synthesis, release, reuptake and degradation; AUF1 (hnRNP D0) binds and destabilizes mRNA; Protein methylation | 20 | 20 | 20 | 20 | 1.586 | 1.511 | 0.674 | 3.559 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.987939278265184 | 0.953011140807089 | 0.709593139419252 | 0.587315224195015 | 247063.168316828 | 221267.865667273 | 228333.997143376 | 2.34302361722569E7 | 1.91610816116977E7 | 2.44529780700925E7 | 1.52458610795295E7 | 1.21057626921531E7 | 1.98188188374949E7 | 4.35786305197153E7 | 3.523488629513E7 | 2.44125225303247E7 | 1.30838270231471E7 | 9679200.3009757 | 1.32405397257932E7 |
| Q9JHU4 | Cytoplasmic dynein 1 heavy chain 1 [OS=Mus musculus] | 161.009 | 14 | 55 | 258 | 55 | 4644 | 531.7 | cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes | cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 13424 | ENSMUSG00000018707 | Dync1h1 | E9QM71; mmu:13424; Q9JHU4 | MHC class II antigen presentation; Neutrophil degranulation; Separation of Sister Chromatids; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; COPI-mediated anterograde transport; Recruitment of NuMA to mitotic centrosomes; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-independent Golgi-to-ER retrograde traffic; Aggrephagy; Anchoring of the basal body to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; AURKA Activation by TPX2 | 0.975 | 1.246 | 1.606 | 1.856 | 2.687 | 1.626 | 1.854 | 2.534 | 0.591873375996003 | 0.826895204418257 | 0.758743075163871 | 0.936818656936794 | 0.771389136401717 | 0.987352798667733 | 0.695927216301667 | 0.953305976192702 | 224060.75101347 | 288932.991027563 | 370866.333925136 | 1035717.43113769 | 1898525.78207622 | 892363.147243056 | 298543.620628635 | 395801.785314415 | 659710.172961205 | 5741364.17159479 | 5412980.23144293 | 4332188.15134028 | 1541170.38578568 | 1219184.02821873 | 1626625.47525789 | |
| Q99K41 | EMILIN-1 [OS=Mus musculus] | 157.011 | 31 | 21 | 244 | 21 | 1017 | 107.5 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 100952 | ENSMUSG00000029163 | Emilin1 | mmu:100952; Q99K41 | Molecules associated with elastic fibres | 20 | 20 | 20 | 20 | 0.468 | 2.622 | 0.322 | 3.831 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.169879542413978 | 0.64186124184599 | 0.0921665663508908 | 0.491906845171331 | 6287128.66260445 | 6034831.78772075 | 4173278.84836641 | 1744058.35010072 | 1513530.29654839 | 1757558.94039384 | 2698540.13579468 | 2559754.7470142 | 1836473.80243277 | 371444.218276851 | 286714.652107864 | 495091.120602366 | ||||
| Q61879 | Myosin-10 [OS=Mus musculus] | 146 | 19 | 31 | 236 | 20 | 1976 | 228.9 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;nucleic acid binding activity;other molecular function | 77579 | ENSMUSG00000020900 | Myh10 | mmu:77579; Q5SV63; Q61879 | Regulation of actin cytoskeleton | RHO GTPases activate PAKs | 1.209 | 0.791 | 1.357 | 2.489 | 1.52 | 1.681 | 1.232 | 2.649 | 0.705689538076567 | 0.506231596289679 | 0.676239752697828 | 0.933545599871938 | 0.996007724449986 | 0.990096171400123 | 0.953146340313072 | 0.921444667457376 | 132922.802732814 | 81410.1821075416 | 155803.703539863 | 578601.376274227 | 569525.366217458 | 228469.06472958 | 249877.75631 | 195698.454667987 | 352494.602688902 | 1222751.03080206 | 1020719.46631895 | 1025108.65415173 | 659882.564109888 | 489393.525760184 | 539451.948957579 |
| Cont_P00761 | Trypsin OS=Sus scrofa OX=9823 PE=1 SV=1 | 143.502 | 62 | 11 | 3859 | 10 | 231 | 24.4 | protein metabolism;other biological processes | non-structural extracellular | other molecular function | 0.498 | 0.443 | 0.689 | 0.579 | 0.942 | 1.146 | 1.203 | 1.114 | 0.254996071775817 | 0.172153475402034 | 0.357784551188889 | 0.34040294575649 | 0.822223648478518 | 0.740968241512781 | 0.960577895552113 | 0.148582186670595 | 5.17896971017178E9 | 5.13317471139103E9 | 7.27761160813741E9 | 2.70973552724487E9 | 1.73168232498425E9 | 2.0962236592694E9 | 3.08554430734093E9 | 3.85764460784296E9 | 3.06099934235171E9 | 1.42194297351806E9 | 1.8379662886425E9 | 3.81973460995747E9 | 5.23567407489624E9 | 5.3849654871275E9 | 2.81761370832162E9 | ||||||
| P20029 | Endoplasmic reticulum chaperone BiP [OS=Mus musculus] | 142.966 | 48 | 25 | 434 | 23 | 655 | 72.4 | protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component | enzyme regulator activity;translation activity;other molecular function | 14828 | ENSMUSG00000026864 | Hspa5 | mmu:14828; O35642; P20029; Q3UFF2; Q61630 | Mapk signaling pathway | Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Regulation of HSF1-mediated heat shock response | 20 | 20 | 20 | 20 | 2.034 | 1.181 | 1.138 | 2.043 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.916283277860523 | 0.769590657123576 | 0.985707795620743 | 0.888702680095366 | 7850142.93480902 | 7648809.53150357 | 9169945.31743656 | 7535475.80605118 | 5802650.52918468 | 8839942.11003441 | 1.89485602512479E7 | 1.6006905998567E7 | 1.24118184289709E7 | 8533209.24248049 | 7216046.0503345 | 9459779.49149077 | |||
| Cont_P13647 | Keratin, type II cytoskeletal 5 OS=Homo sapiens OX=9606 GN=KRT5 PE=1 SV=3 | 142.395 | 51 | 34 | 500 | 20 | 590 | 62.3 | cell organization and biogenesis;other biological processes | cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;cytoskeletal activity;other molecular function | 3852 | ENSG00000186081 | KRT5 | hsa:3852; P13647; Q6PI71; Q6UBJ0; Q8TA91 | Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin; Developmental Lineage of Mammary Stem Cells; Developmental Lineage of Mammary Gland Myoepithelial Cells; Type I hemidesmosome assembly | 1.412 | 1.296 | 1.45 | 3.637 | 1.063 | 1.124 | 2.854 | 0.442 | 0.786915923361782 | 0.847457711018997 | 0.707170943024881 | 0.746833150482801 | 0.873755746039336 | 0.714156118974909 | 0.2733017775894 | 2.49132633766938E-5 | 5120503.46953844 | 5171426.92187225 | 6553368.21772984 | 9669299.63907403 | 1.1127930529353E7 | 9127716.50969809 | 9513581.76230213 | 7584977.17814252 | 6506980.60696686 | 1.59683716443188E7 | 1.28154121523541E7 | 1.32126695164861E7 | 5.39600661696836E7 | 1.8678004759752E7 | 1.36191738010446E7 | |
| Cont_P08779 | Keratin, type I cytoskeletal 16 OS=Homo sapiens OX=9606 GN=KRT16 PE=1 SV=4 | 140.751 | 54 | 25 | 569 | 12 | 473 | 51.2 | cell organization and biogenesis;stress response;other biological processes | plasma membrane;cytosol;cytoskeleton | cytoskeletal activity | 3868 | ENSG00000186832 | KRT16 | A8K488; hsa:3868; P08779; P30654; Q16402; Q9UBG8 | Vitamin D receptor pathway | Formation of the cornified envelope | 1.858 | 1.769 | 1.616 | 2.725 | 0.945 | 0.933 | 1.398 | 0.544 | 0.941324060398065 | 0.961351301268194 | 0.761460393544015 | 0.887279041944908 | 0.82543231800733 | 0.493923182294169 | 0.895302208460818 | 3.1065941501805E-4 | 1047544.82178002 | 1389728.97312405 | 1389730.63830375 | 1501449.09449526 | 2307427.01338473 | 2939547.44501319 | 7196685.12946156 | 1715910.61220057 | 2812173.28112121 | 4331979.12309994 | 1639569.64130669 | 1737373.70058763 | 9547147.41410007 | 4434008.92515372 | 2223613.02167429 |
| Cont_P02465 | Collagen alpha-2(I) chain OS=Bos taurus OX=9913 GN=COL1A2 PE=1 SV=2 | 139.99 | 18 | 19 | 445 | 3 | 1364 | 129 | non-structural extracellular;extracellular matrix | extracellular structural activity;other molecular function | 282188 | ENSBTAG00000013472 | COL1A2 | A6QP13; bta:282188; O62649; P02465 | Inflammatory response pathway; Focal adhesion | Fibronectin matrix formation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Collagen degradation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; Collagen chain trimerization; GPVI-mediated activation cascade; Platelet Aggregation (Plug Formation); Platelet Adhesion to exposed collagen; GP1b-IX-V activation signalling | 0.802 | 1.357 | 0.812 | 0.776 | 0.839 | 0.601 | 0.572 | 1.046 | 0.483779141493222 | 0.876027096029978 | 0.421836754550416 | 0.488872343346086 | 0.731850662833984 | 0.076245756040016 | 0.549852418071669 | 0.432748651973214 | 80849.8235508145 | 93725.5578519836 | 35755.9745173747 | 170240.553800628 | 153570.468872413 | 167384.810476394 | 78292.6458688874 | 70345.2867467554 | 108688.239366299 | 65032.7123193958 | 48396.6073357386 | 51482.0177898574 | 32903.9376967684 | 51011.1923790395 | 62191.0072542807 | |
| Cont_P12763 | Alpha-2-HS-glycoprotein OS=Bos taurus OX=9913 GN=AHSG PE=1 SV=2 | 132.772 | 50 | 16 | 1191 | 16 | 359 | 38.4 | stress response;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component | enzyme regulator activity | 280988 | AHSG | A6QLF7; bta:280988; P12763 | Neutrophil degranulation; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 0.943 | 1.184 | 1.213 | 0.612 | 1.313 | 0.781 | 0.463 | 2.11 | 0.573667790345329 | 0.793013134473823 | 0.624272910267193 | 0.36488675645736 | 0.946568086066385 | 0.268930374946741 | 0.335956814949331 | 0.913214993335179 | 6.75081036645858E8 | 9.56771805796805E8 | 4.32862555462728E8 | 6.04790296716478E8 | 6.42824998486085E8 | 6.76887564991134E8 | 8.54466282868744E8 | 8.4303805016043E8 | 9.16216503216691E8 | 7.41908408260606E8 | 7.48114705273509E8 | 6.29285280642112E8 | 3.25834950231514E8 | 3.42283489676807E8 | 6.64083343401506E8 | ||
| P07901 | Heat shock protein HSP 90-alpha [OS=Mus musculus] | 132.382 | 43 | 25 | 402 | 16 | 733 | 84.7 | cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component | signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function | 15519 | ENSMUSG00000021270 | Hsp90aa1 | mmu:15519; P07901 | EBV LMP1 signaling; Focal adhesion: PI3K-Akt-mTOR signaling pathway; IL-6 signaling pathway; IL-2 signaling pathway | Regulation of necroptotic cell death; Recruitment of NuMA to mitotic centrosomes; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of actin dynamics for phagocytic cup formation; Neutrophil degranulation; Downregulation of ERBB2 signaling; Anchoring of the basal body to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; AURKA Activation by TPX2; Extra-nuclear estrogen signaling; Attenuation phase; Estrogen-dependent gene expression; Sema3A PAK dependent Axon repulsion; VEGFR2 mediated vascular permeability; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation; DDX58/IFIH1-mediated induction of interferon-alpha/beta; eNOS activation; HSF1 activation; RHOBTB2 GTPase cycle; Drug-mediated inhibition of ERBB2 signaling | 20 | 0.796 | 20 | 9.684 | 1.447 | 2.287 | 1.041 | 3.222 | 1.65082956259427E-17 | 0.508730894200713 | 1.50457038391225E-17 | 0.251664970734015 | 0.974827674952665 | 0.788764875934969 | 0.968364585136618 | 0.745600589176001 | 51071.3130902855 | 169244.190500369 | 193833.457176882 | 3826029.08230807 | 4600695.96516161 | 3479662.10980986 | 1533159.7098775 | 1700635.66665037 | 1768278.53880507 | 6471421.59388824 | 6122550.53993506 | 5450079.38924241 | 1704183.40484156 | 900341.190737514 | 2215799.13247972 |
| Q02819 | Nucleobindin-1 [OS=Mus musculus] | 131.152 | 51 | 21 | 299 | 21 | 459 | 53.4 | signal transduction | non-structural extracellular;other membranes;ER/Golgi | enzyme regulator activity;nucleic acid binding activity;other molecular function | 18220 | ENSMUSG00000030824 | Nucb1 | mmu:18220; Q02819; Q3TU42; Q9CWA1; Q9D8J4; Q9DBL3 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 20 | 20 | 20 | 14.326 | 0.375 | 3.321 | 0.498 | 2.52 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 0.130903496983571 | 0.0679830640731695 | 0.340647566778883 | 0.397987186613988 | 0.958122559708965 | 41072.7931792495 | 20198.6046706008 | 1.70846710933602E7 | 1.97547416617741E7 | 2.08807433533847E7 | 5757191.6972993 | 4828078.95450858 | 5895038.38978249 | 7136546.74332753 | 7387752.88718417 | 5120327.81590923 | 2637872.59598673 | 1130733.36645935 | 3369667.63744922 | ||
| Q91V92 | ATP-citrate synthase [OS=Mus musculus] | 129.973 | 32 | 28 | 237 | 28 | 1091 | 119.7 | other metabolic processes | cytosol | other molecular function | 104112 | ENSMUSG00000020917 | Acly | mmu:104112; Q91V92 | Fatty acid biosynthesis | Neutrophil degranulation; Fatty acyl-CoA biosynthesis | 9.31 | 4.235 | 7.838 | 5.627 | 0.759 | 1.697 | 0.624 | 2.139 | 0.230775890814232 | 0.371468864113786 | 0.437429424171984 | 0.509570119936397 | 0.626059420687734 | 0.98558531112136 | 0.643183834410259 | 0.922580167429744 | 8856.99380706579 | 32765.2400642807 | 40990.0091117865 | 2382723.31982566 | 2481678.51703659 | 2154876.39410613 | 1256305.5375454 | 885993.369046538 | 1688459.92743218 | 2057502.05407172 | 1815562.79058184 | 1460220.9588277 | 594587.914542531 | 534991.757912276 | 802971.776166877 |
| A2ASQ1 | Agrin [OS=Mus musculus] | 128.989 | 18 | 26 | 227 | 26 | 1950 | 207.4 | cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cell component | signal transduction activity or receptor binding;other molecular function | 11603 | ENSMUSG00000041936 | Agrn | A2ASP9; A2ASQ0; A2ASQ1; B2RWU1 | Primary focal segmental glomerulosclerosis (FSGS) | ECM proteoglycans; Retinoid metabolism and transport; Glycosaminoglycan-protein linkage region biosynthesis; HS-GAG biosynthesis; HS-GAG degradation; Formation of the dystrophin-glycoprotein complex (DGC) | 20 | 20 | 20 | 20 | 0.661 | 1.77 | 0.657 | 1.948 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.460727828548759 | 0.972791368602389 | 0.686318824668434 | 0.846971399004193 | 2612028.52511147 | 3116500.52541199 | 3328171.1398056 | 1818519.74579979 | 1551006.46226864 | 1715477.48863677 | 2313945.16119856 | 2044906.61336417 | 1778324.63596447 | 957812.214242183 | 632566.873707257 | 1496109.18442141 | |||
| Q61508 | Extracellular matrix protein 1 [OS=Mus musculus] | 127.379 | 45 | 18 | 358 | 18 | 559 | 62.8 | stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular | signal transduction activity or receptor binding;other molecular function | 13601 | ENSMUSG00000028108 | Ecm1 | mmu:13601; Q3U5Q5; Q61508 | Platelet degranulation | 20 | 20 | 20 | 14.914 | 0.149 | 1.214 | 0.053 | 3.546 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 0.121600547823456 | 2.27890527565265E-4 | 0.795351011232032 | 1.51989274634622E-7 | 0.592370654746194 | 110159.96586707 | 68619.5270607555 | 45654.6843175291 | 5.6443097497098E7 | 7.11751205740166E7 | 5.82782830048746E7 | 5.1935854689884E7 | 4.50204039942893E7 | 5.70225374161979E7 | 1.27540105597053E7 | 1.25514774649527E7 | 8690203.83604475 | 3690111.31703252 | 2192350.97546663 | 4663417.73981907 | |
| Cont_P04259 | Keratin, type II cytoskeletal 6B OS=Homo sapiens OX=9606 GN=KRT6B PE=1 SV=5 | 126.901 | 47 | 30 | 442 | 4 | 564 | 60 | cell organization and biogenesis;other biological processes | cytosol;cytoskeleton | bone, tooth or skin structural activity;cytoskeletal activity | 3854 | ENSG00000185479 | KRT6B | hsa:3854; P04259; P48669 | Formation of the cornified envelope | 1.588 | 2.045 | 1.606 | 3.292 | 1.017 | 0.828 | 1.287 | 0.641 | 0.857251372850113 | 0.868132360832926 | 0.758743075163871 | 0.801271130817871 | 0.854305439376382 | 0.340133476321195 | 0.937453377971347 | 0.00123883404563536 | 267279.779286483 | 355493.362381868 | 274137.281616349 | 326989.588402741 | 585438.697100962 | 617622.938974811 | 2390973.53573307 | 430931.486741926 | 646270.614315847 | 1869779.42318807 | 346417.77494154 | 348508.009299423 | 1653754.7898307 | 1155463.67620058 | 538093.594898596 | |
| P17182 | Alpha-enolase [OS=Mus musculus] | 126.804 | 60 | 19 | 244 | 16 | 434 | 47.1 | other metabolic processes;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;other cell component | nucleic acid binding activity;other molecular function | 13806; 433182 | ENSMUSG00000059040; ENSMUSG00000063524 | Eno1 | mmu:13806; mmu:433182; P17182; Q99KT7; Q9DCY7 | Glycolysis and gluconeogenesis | 20 | 20 | 20 | 20 | 2.837 | 1.204 | 1.518 | 2.329 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.720832939248489 | 0.789540446904924 | 0.858218537342417 | 0.989544231571828 | 31098.019126098 | 70318.9502605952 | 40658.6319347469 | 1.28655809626545E7 | 1.34726279447959E7 | 7101469.5445256 | 9089751.86845938 | 7552189.93174957 | 1.17772011823713E7 | 3.50544676757808E7 | 2.99447661492486E7 | 2.18255690502528E7 | 1.30151947674988E7 | 1.11532480577619E7 | 1.75489228796712E7 | |
| P08113 | Endoplasmin [OS=Mus musculus] | 126.346 | 39 | 26 | 329 | 25 | 802 | 92.4 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cell component | signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function | 22027 | ENSMUSG00000020048 | Hsp90b1 | mmu:22027; P08113; P11427 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Hypoxia-dependent self-renewal of myoblasts | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Scavenging by Class A Receptors; Trafficking and processing of endosomal TLR; Interleukin-4 and Interleukin-13 signaling | 14.282 | 15.982 | 20 | 11.019 | 2.346 | 1.275 | 1.501 | 2.064 | 0.107476768049312 | 0.0104456807471941 | 1.50457038391225E-17 | 0.205304099107124 | 0.854305439376382 | 0.840785133352029 | 0.866766165039268 | 0.896996950298791 | 75656.6139115948 | 52183.5314261123 | 29905.9702816436 | 5932785.14172209 | 5786569.94317903 | 3299962.37110113 | 3817668.17887426 | 3366255.7650389 | 4907428.60350699 | 1.47606948013545E7 | 1.21020755462977E7 | 1.0441016038914E7 | 6464144.86133097 | 3792376.91369813 | 7854793.82920015 |
| P58252 | Elongation factor 2 [OS=Mus musculus] | 126.048 | 37 | 31 | 378 | 30 | 858 | 95.3 | cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;translational apparatus;other cell component | cytoskeletal activity;translation activity;nucleic acid binding activity;other molecular function | 13629 | ENSMUSG00000034994 | Eef2 | mmu:13629; P58252; Q544E4 | Translation factors | Neutrophil degranulation; Protein methylation; Peptide chain elongation; Synthesis of diphthamide-EEF2 | 7.873 | 5.944 | 7.322 | 3.019 | 1.183 | 1.75 | 0.816 | 2.548 | 0.299809054080284 | 0.188334321166369 | 0.471929633209224 | 0.84258396038376 | 0.922179983282929 | 0.97504218639442 | 0.866546043492515 | 0.950878070645738 | 275529.241689771 | 247076.7728808 | 166294.142173825 | 1.22498155967913E7 | 1.26488626480754E7 | 6800245.14611723 | 5717562.35282925 | 5172569.64432748 | 8352282.82529915 | 1.55667000517401E7 | 1.33925688878402E7 | 1.02378508629272E7 | 5184391.52691505 | 2972661.18095993 | 6421886.97759523 |
| Cont_P02538 | Keratin, type II cytoskeletal 6A OS=Homo sapiens OX=9606 GN=KRT6A PE=1 SV=3 | 123.757 | 47 | 30 | 454 | 3 | 564 | 60 | cell organization and biogenesis;stress response;other biological processes | cytosol;cytoskeleton | bone, tooth or skin structural activity;cytoskeletal activity | 3853 | ENSG00000205420 | KRT6A | A4QPC1; hsa:3853; P02538; P48667; Q08AR4; Q6NT67; Q96CL4 | Ectoderm differentiation; Ectoderm differentiation; Pancreatic cancer subtypes | Formation of the cornified envelope | 1.699 | 1.759 | 1.562 | 3.017 | 0.903 | 0.993 | 1.821 | 0.574 | 0.892533464536408 | 0.964633336683333 | 0.745886066139481 | 0.84258396038376 | 0.792564971776066 | 0.574739141583974 | 0.709593139419252 | 5.66461038960431E-4 | 2017098.82314832 | 2171650.09464557 | 2359880.73116726 | 2825309.68904382 | 4320098.03084773 | 4192074.59940388 | 8075888.41129776 | 2685265.07688442 | 3594101.84504227 | 5878699.8667026 | 3215829.01184206 | 2854010.96069105 | 1.30998597349634E7 | 8158147.16608847 | 4198498.19802621 |
| P97298 | Pigment epithelium-derived factor [OS=Mus musculus] | 123.502 | 47 | 16 | 346 | 12 | 417 | 46.2 | cell cycle OR cell proliferation;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | enzyme regulator activity | 20317 | ENSMUSG00000000753 | Serpinf1 | mmu:20317; O70629; O88691; P97298 | 20 | 5.45 | 7.9 | 3.48 | 0.255 | 3.903 | 0.445 | 2.758 | 1.65082956259427E-17 | 0.227296093012204 | 0.434748506750565 | 0.770205086382264 | 0.00901230529014985 | 0.174886032348437 | 0.300753028734261 | 0.891044455497809 | 554016.1710638 | 470705.490372182 | 363015.858993357 | 5.24905837082578E7 | 7.20656975211191E7 | 8.90978835263609E7 | 1.55195541438312E7 | 1.33807646088142E7 | 1.504676823338E7 | 1.63245792137601E7 | 1.5700230598517E7 | 1.5246806329463E7 | 4897006.93274029 | 3869051.7420588 | 8996988.40278734 | ||
| Q70E20 | Sushi, nidogen and EGF-like domain-containing protein 1 [OS=Mus musculus] | 122.942 | 19 | 22 | 287 | 22 | 1403 | 151.5 | cell adhesion | non-structural extracellular;extracellular matrix | other molecular function | 208777 | Sned1 | A6H6I3; mmu:208777; Q70E20; Q810H2; Q8BMD9 | 20 | 20 | 20 | 20 | 2.169 | 2.063 | 1.623 | 2.787 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.889058672589993 | 0.869908412860824 | 0.817293288705596 | 0.880760468933162 | 62940.5062355012 | 25184.2741656831 | 25459.8187779288 | 7879183.70581794 | 8304827.25748066 | 2617617.70526214 | 3110990.0320528 | 3263544.92621848 | 3507274.08693078 | 1.72480350493842E7 | 1.48489121993504E7 | 1.05732378776404E7 | 5373074.41423662 | 2537287.1447922 | 7075122.99473268 | |||
| P13020 | Gelsolin [OS=Mus musculus] | 122.934 | 35 | 22 | 377 | 9 | 780 | 85.9 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 227753 | ENSMUSG00000026879 | Gsn | mmu:227753; P13020; Q3UPB1; Q8R590 | Regulation of actin cytoskeleton | Neutrophil degranulation; Caspase-mediated cleavage of cytoskeletal proteins | 5.883 | 4.057 | 14.912 | 7.221 | 3.038 | 1.646 | 1.821 | 3.103 | 0.440427841758307 | 0.396306424610341 | 0.186266168629733 | 0.379422692457324 | 0.65414435708462 | 0.994546642862744 | 0.709593139419252 | 0.793590033024783 | 1154075.61374729 | 1486973.5078743 | 778278.604931373 | 1.0611315000974E7 | 9755419.92114226 | 9110194.21443976 | 6039243.17546894 | 5549542.61366164 | 7725308.54354706 | 3.63344365935893E7 | 2.77403609084757E7 | 2.33574049877416E7 | 1.03453705657478E7 | 8417203.0170929 | 1.43392014575414E7 |
| Q61398 | Procollagen C-endopeptidase enhancer 1 [OS=Mus musculus] | 120.4 | 40 | 14 | 323 | 14 | 468 | 50.1 | protein metabolism;other biological processes | enzyme regulator activity;other molecular function | 18542 | ENSMUSG00000029718 | Pcolce | mmu:18542; O35113; Q61398 | mRNA processing | Collagen biosynthesis and modifying enzymes; Crosslinking of collagen fibrils | 20 | 20 | 16.934 | 8.868 | 0.439 | 1.204 | 0.32 | 1.719 | 1.65082956259427E-17 | 1.8644578313253E-17 | 0.151224536345852 | 0.288320039261486 | 0.133905327763598 | 0.789540446904924 | 0.0895861566882082 | 0.711902858921665 | 55825.2363051742 | 84655.3590880939 | 113029.200120433 | 3.10244208090572E7 | 2.97623271730106E7 | 2.79757713270171E7 | 2.72578314339105E7 | 2.28908828526637E7 | 2.54654481194513E7 | 1.54882233602667E7 | 1.24902767859117E7 | 9636426.2851997 | 7984547.74798259 | 5125325.32901055 | 9907837.52014591 | |
| P26039 | Talin-1 [OS=Mus musculus] | 118.226 | 15 | 30 | 153 | 30 | 2541 | 269.7 | cell adhesion;cell organization and biogenesis;signal transduction | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;other molecular function | 21894 | ENSMUSG00000028465 | Tln1 | A2AIM8; mmu:21894; P26039; Q8VEF0 | Primary focal segmental glomerulosclerosis (FSGS); Integrin-mediated cell adhesion; Focal adhesion | Platelet degranulation ; MAP2K and MAPK activation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; Smooth Muscle Contraction; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 2.278 | 1.64 | 4.713 | 1.234 | 2.379 | 2.301 | 1.474 | 3.671 | 0.958262397335385 | 0.994542145304377 | 0.680632778351053 | 0.738983404380581 | 0.850917681937748 | 0.783910800136359 | 0.87222702623065 | 0.535066779633529 | 137218.697336797 | 64798.4580467583 | 241653.653741064 | 580168.664793601 | 803244.58151111 | 320387.746187394 | 118081.406885094 | 124079.798936285 | 255551.526824265 | 2877993.84785898 | 2114900.66089323 | 1881659.61273992 | 234819.255172709 | 240671.449108311 | 385063.079961369 |
| Q8BPB5 | EGF-containing fibulin-like extracellular matrix protein 1 [OS=Mus musculus] | 117.738 | 49 | 15 | 220 | 15 | 493 | 54.9 | protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes | extracellular matrix | signal transduction activity or receptor binding;kinase activity;other molecular function | 216616 | ENSMUSG00000020467 | Efemp1 | mmu:216616; Q6Y3N6; Q8BPB5 | 20 | 20 | 20 | 7.265 | 0.542 | 1.608 | 0.36 | 2.306 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 0.376780684027729 | 0.278244203695445 | 0.983440558239231 | 0.145805028390539 | 0.982581944728745 | 15298.8221438323 | 19141.8575027524 | 55545.7753728227 | 7090020.68988726 | 8805500.10345141 | 5126350.07183034 | 4435222.67421531 | 4392813.74676133 | 4496081.41897935 | 4016966.57007158 | 3984703.05528875 | 2817881.79753384 | 1462163.85427198 | 682456.349264741 | 1966499.77195883 | ||
| P09411 | Phosphoglycerate kinase 1 [OS=Mus musculus] | 116.462 | 57 | 18 | 287 | 18 | 417 | 44.5 | protein metabolism;other metabolic processes;stress response;other biological processes | non-structural extracellular;other membranes;cytosol;mitochondrion;other cell component | kinase activity;other molecular function | 18655 | ENSMUSG00000062070 | Pgk1 | mmu:18655; P09411; Q3TPE6; Q3UKV8; Q5XJE7 | Glycolysis and gluconeogenesis | Gluconeogenesis; Glycolysis | 20 | 20 | 20 | 20 | 3.557 | 1.177 | 1.619 | 2.753 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.465126095372736 | 0.766862952867809 | 0.820281310709571 | 0.891044455497809 | 78089.4641074341 | 38741.0917691314 | 23421.0514741904 | 4316274.39280249 | 5023293.68471847 | 1442874.888393 | 2829873.33459098 | 2934698.045784 | 3868274.47312523 | 1.65254946701665E7 | 1.56270051770472E7 | 1.22346365889796E7 | 4530199.20599689 | 2315853.03926933 | 6654180.61411261 |
| P27773 | Protein disulfide-isomerase A3 [OS=Mus musculus] | 115.891 | 55 | 23 | 291 | 23 | 505 | 56.6 | cell adhesion;cell organization and biogenesis;stress response;signal transduction;other biological processes | non-structural extracellular;other membranes;ER/Golgi;other cell component | nucleic acid binding activity;other molecular function | 14827 | ENSMUSG00000027248 | Pdia3 | mmu:14827; P27773; Q3TEI9; Q3TIL2; Q3UZK8; Q8C2F4; Q99LF6 | ER-Phagosome pathway; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Calnexin/calreticulin cycle | 2.463 | 2.512 | 6.915 | 2.818 | 2.389 | 1.306 | 1.442 | 2.187 | 0.9135584231482 | 0.736536116100563 | 0.498293621965442 | 0.874168055361729 | 0.850917681937748 | 0.862063111456553 | 0.881496352314601 | 0.939046770372612 | 206281.038958907 | 253939.7116523 | 128510.108086966 | 6669793.66068216 | 7133803.24141356 | 5637352.69437344 | 5319375.96186612 | 3844376.07822282 | 6321729.00885173 | 1.83298906806341E7 | 1.50101054148645E7 | 1.26051366299531E7 | 6670485.36185494 | 6059857.55300524 | 8984695.03809976 | |
| P10107 | Annexin A1 [OS=Mus musculus] | 115.566 | 64 | 18 | 270 | 18 | 346 | 38.7 | cell organization and biogenesis;stress response;transport;signal transduction;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component | enzyme regulator activity;other molecular function | 16952 | ENSMUSG00000024659 | Anxa1 | mmu:16952; P10107 | Spinal cord injury; Prostaglandin synthesis and regulation | G alpha (q) signalling events; G alpha (i) signalling events; Formyl peptide receptors bind formyl peptides and many other ligands | 20 | 7.59 | 20 | 20 | 1.749 | 3.163 | 2.185 | 2.632 | 1.65082956259427E-17 | 0.105053536950499 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.954328834404239 | 0.401885831342676 | 0.529099828181544 | 0.924766494197286 | 13280.9290610842 | 9160.53166722029 | 4508.77124840677 | 5251880.61554565 | 6740833.31198439 | 6058745.6526555 | 1560362.01883491 | 1521121.84391776 | 1946127.08618424 | 1.11990207127477E7 | 1.0990927807692E7 | 1.0321301103113E7 | 4605609.45936174 | 3223846.7434476 | 4805492.80063037 |
| Cont_Q2KJF1 | Alpha-1B-glycoprotein OS=Bos taurus OX=9913 GN=A1BG PE=1 SV=1 | 115.502 | 48 | 14 | 224 | 14 | 503 | 53.5 | signal transduction | non-structural extracellular;plasma membrane;other membranes | 518955 | A1BG | bta:518955; Q2KJF1 | Platelet degranulation ; Neutrophil degranulation | 1.057 | 0.967 | 1.256 | 0.607 | 1.203 | 1.109 | 0.599 | 2.051 | 0.635218461842139 | 0.655487072215252 | 0.641514600397631 | 0.360991986803736 | 0.932231143665149 | 0.696358249006924 | 0.601376052147163 | 0.891044455497809 | 1.12339445909494E7 | 1.09217008752481E7 | 5999938.28834399 | 7597724.26810103 | 8696294.29830821 | 1.02832125493257E7 | 1.08372253099689E7 | 9914324.88654618 | 8710997.51604168 | 1.11963323092602E7 | 9450705.94975847 | 1.03053408353504E7 | 5283853.74244175 | 5535891.07899516 | 9467766.08082133 | |||
| Cont_Q3MHN5 | Vitamin D-binding protein OS=Bos taurus OX=9913 GN=GC PE=2 SV=1 | 113.599 | 55 | 20 | 319 | 20 | 474 | 53.3 | other metabolic processes;transport | non-structural extracellular;other cell component | transporter activity;cytoskeletal activity;other molecular function | 530076 | GC | bta:530076; Q3MHN5 | 0.903 | 1.209 | 1.108 | 0.763 | 1.298 | 0.671 | 0.583 | 1.405 | 0.549057967251154 | 0.804331105646976 | 0.579435037816218 | 0.479472599858427 | 0.946173787415917 | 0.139718417146003 | 0.570795727084329 | 0.421365656927814 | 1.55879441314789E7 | 1.53074066841615E7 | 7458694.29508707 | 1.04365108192777E7 | 1.20620475306269E7 | 8309099.82300618 | 1.67215053413279E7 | 1.54231806136738E7 | 1.57780518794517E7 | 1.6556516146824E7 | 1.52311500265876E7 | 1.20681229464E7 | 8133055.93664235 | 9478628.98672491 | 1.47438110125204E7 | |||
| P17742 | Peptidyl-prolyl cis-trans isomerase A [OS=Mus musculus] | 113.527 | 60 | 9 | 369 | 9 | 164 | 18 | cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes | non-structural extracellular;cytosol;nucleus;other cell component | signal transduction activity or receptor binding;other molecular function | 268373 | ENSMUSG00000071866 | Ppia | mmu:268373; P17742; Q9CWJ5; Q9R137 | Neutrophil degranulation; Basigin interactions | 14.843 | 7.75 | 20 | 20 | 1.304 | 2.489 | 0.969 | 4.305 | 0.100219677394751 | 0.099382125133403 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.946239447314336 | 0.696358249006924 | 0.937453377971347 | 0.331144967260478 | 1.16891341386391E7 | 754837.409863468 | 4157779.88062054 | 2.9189343463191E7 | 2.94929696895869E7 | 4.96473559496876E7 | 1.04342545713823E7 | 8178713.43858634 | 1.18234267071803E7 | 4.91534751033825E7 | 4.2865019365108E7 | 4.61937263356195E7 | 9682919.1999608 | 7275434.18699702 | 1.51319991253865E7 | |
| Q69ZN7 | Myoferlin [OS=Mus musculus] | 112.647 | 22 | 36 | 227 | 36 | 2048 | 233.2 | cell organization and biogenesis;other metabolic processes;stress response;other biological processes | plasma membrane;other membranes;nucleus | other molecular function | 226101 | ENSMUSG00000048612 | Myof | mmu:226101; Q69ZN7; Q7TMG0; Q80V33; Q8BU64; Q8BU70; Q8BUC1; Q8BVY6; Q8C0D1; Q8R3B4 | 1.293 | 1.754 | 2.079 | 1.82 | 2.532 | 2.029 | 2.027 | 2.284 | 0.73657372909066 | 0.964709887217926 | 0.888974672311279 | 0.930955411749965 | 0.816275429153737 | 0.877818946381645 | 0.609903091678244 | 0.975029032316037 | 86000.3771233404 | 87234.2597428081 | 50456.7230101595 | 780930.944201502 | 985609.680593147 | 968573.73043394 | 296294.389327177 | 289800.794039455 | 380995.072506467 | 3324626.35891918 | 3238695.05806667 | 2634093.62813707 | 1025817.2029614 | 993761.586050851 | 1295229.11918404 | ||
| P26041 | Moesin [OS=Mus musculus] | 112.068 | 47 | 28 | 353 | 19 | 577 | 67.7 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function | 17698 | ENSMUSG00000031207 | Msn | B1AX70; mmu:17698; P26041; Q3UL28; Q8BSN4 | Regulation of actin cytoskeleton | Recycling pathway of L1 | 20 | 9.275 | 20 | 12.906 | 1.135 | 2.551 | 1.147 | 2.527 | 1.65082956259427E-17 | 0.0604972675946614 | 1.50457038391225E-17 | 0.157138696252226 | 0.910750689050232 | 0.682171843898269 | 0.97925982662951 | 0.954396180425051 | 3509434.20481405 | 4360753.56845675 | 2823311.97478394 | 1.57847182977139E7 | 1.58696599538661E7 | 1.95033967654703E7 | 8383545.44173348 | 7552431.53754312 | 1.1473115873696E7 | 2.43209045148915E7 | 1.7265255344344E7 | 1.55060800034236E7 | 7954804.76477835 | 1.24969658442338E7 | 1.31486313258361E7 |
| P05064 | Fructose-bisphosphate aldolase A [OS=Mus musculus] | 112.015 | 66 | 18 | 261 | 18 | 364 | 39.3 | cell organization and biogenesis;other metabolic processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | other molecular function | 11674 | ENSMUSG00000030695 | Aldoa | mmu:11674; P05064 | Glycolysis and gluconeogenesis | Platelet degranulation ; Neutrophil degranulation; Gluconeogenesis; Glycolysis | 14.735 | 18.407 | 20 | 18.77 | 2.091 | 1.259 | 1.091 | 2.228 | 0.101571037453114 | 0.00616383846364181 | 1.50457038391225E-17 | 0.0771819601934254 | 0.907383519445145 | 0.828577692034317 | 0.988377544628277 | 0.953305976192702 | 36553.7681309936 | 18014.3910425567 | 11156.0078725057 | 5538849.24179232 | 5285372.3367409 | 3856062.26656154 | 4263443.39983126 | 3386915.16711964 | 5306808.16889341 | 1.24814165546298E7 | 1.09515793948855E7 | 8528808.13475854 | 4192052.54158905 | 4075248.71161469 | 5289067.55868911 |
| B2RQC6 | Multifunctional protein CAD [OS=Mus musculus] | 111.853 | 18 | 32 | 111 | 32 | 2225 | 243.1 | other metabolic processes;stress response;transport;developmental processes;other biological processes | cytosol;nucleus;other cell component | kinase activity;other molecular function | 69719 | ENSMUSG00000013629 | Cad | B2RQC6; B7ZN27; mmu:69719 | Mechanisms associated with pluripotency | Pyrimidine biosynthesis | 3.69 | 2.77 | 4.876 | 2.316 | 0.581 | 1.776 | 0.743 | 1.7 | 0.69394578118832 | 0.6681512188534 | 0.666244110962191 | 0.963127218853016 | 0.340675523776301 | 0.968897093792999 | 0.798180783050573 | 0.621633895543644 | 55886.6384121637 | 12993.9975368397 | 34438.2113153553 | 1026045.60319635 | 1025412.85494839 | 821784.178770446 | 383358.762218724 | 322831.339780162 | 640190.890369534 | 516093.312619156 | 478923.162373783 | 363366.537093714 | 127462.003140709 | 110686.677299138 | 180829.981634378 |
| Q8BND5 | Sulfhydryl oxidase 1 [OS=Mus musculus] | 111.186 | 35 | 22 | 242 | 22 | 748 | 82.7 | cell organization and biogenesis;other biological processes | non-structural extracellular;other membranes;ER/Golgi | other molecular function | 104009 | ENSMUSG00000033684 | Qsox1 | mmu:104009; Q3TDY9; Q3TE19; Q3TR29; Q3UEL4; Q8BND5; Q8K041; Q9DBL6 | Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Neutrophil degranulation | 20 | 20 | 20 | 12.613 | 0.491 | 2.489 | 0.46 | 2.797 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 0.162753188077458 | 0.203109767081086 | 0.696358249006924 | 0.331332346840573 | 0.877612009404373 | 40119.4404166161 | 10016.9610840251 | 9134645.28263017 | 1.19624109837519E7 | 1.04856878607794E7 | 3750508.26959308 | 3765475.87858746 | 4032369.19900008 | 5503994.64256118 | 5774708.06447186 | 3841814.38132964 | 1498357.95430882 | 1169677.75963505 | 2786812.01379908 |
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| Accession | Description | Sum PEP Score | Coverage [%] | # Peptides | # PSMs | # Unique Peptides | # AAs | MW [kDa] | Biological Process | Cellular Component | Molecular Function | Entrez Gene ID | Ensembl Gene ID | Gene Symbol | Gene ID | WikiPathways | Reactome Pathways | Abundance Ratio Adj. P-Value: (LQ_16h) / FM | Abundance Ratio Adj. P-Value: (LQ_6h) / FM | Abundance Ratio Adj. P-Value: (SQ_16h) / FM | Abundance Ratio Adj. P-Value: (SQ_6h) / FM | Abundance Ratio Adj. P-Value: (SQ_16h) / (LQ_16h) | Abundance Ratio Adj. P-Value: (LQ_16h) / (LQ_6h) | Abundance Ratio Adj. P-Value: (SQ_6h) / (LQ_6h) | Abundance Ratio Adj. P-Value: (SQ_16h) / (SQ_6h) | Abundances (Normalized): F1: Sample, FM | Abundances (Normalized): F2: Sample, FM | Abundances (Normalized): F3: Sample, FM | FM_AVERAGE | Abundances (Normalized): F8: Sample, LQ_16h | Abundances (Normalized): F9: Sample, LQ_16h | Abundances (Normalized): F10: Sample, LQ_16h | LQ16h_AVERAGE | Abundances (Normalized): F4: Sample, LQ_6h | Abundances (Normalized): F5: Sample, LQ_6h | Abundances (Normalized): F6: Sample, LQ_6h | LQ6h_AVERAGE | Abundances (Normalized): F17: Sample, SQ_16h | Abundances (Normalized): F18: Sample, SQ_16h | Abundances (Normalized): F20: Sample, SQ_16h | SQ16h_AVERAGE | Abundances (Normalized): F15: Sample, SQ_6h | Abundances (Normalized): F16: Sample, SQ_6h | Abundances (Normalized): F14: Sample, SQ_6h | SQ6h_AVERAGE |
| P11276 | Fibronectin [OS=Mus musculus] | 867.353 | 58 | 95 | 2246 | 59 | 2477 | 272.4 | cell adhesion;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi | signal transduction activity or receptor binding;enzyme regulator activity;other molecular function | 14268 | ENSMUSG00000026193 | Fn1 | G5E8B8; mmu:14268; P11276; Q61567; Q61568; Q61569; Q64233; Q80UI4 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Inflammatory response pathway; Regulation of actin cytoskeleton; Comprehensive IL-17A signaling; Focal adhesion | ECM proteoglycans; Platelet degranulation ; Cell surface interactions at the vascular wall; Syndecan interactions; MAP2K and MAPK activation; Integrin cell surface interactions; Molecules associated with elastic fibres; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Fibronectin matrix formation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; Degradation of the extracellular matrix; Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells; MET activates PTK2 signaling; GPER1 signaling | 0.0844744457809114 | 0.00584906503121538 | 1.50457038391225E-17 | 0.156115961659409 | 0.974036928885484 | 0.564710097967506 | 0.435823028559966 | 0.896613838854506 | 3.10111960161575E7 | 2.79853612635427E7 | 2.39278028537136E7 | 2.7641453377804603E7 | 2.27076161669542E8 | 2.29530848002383E8 | 1.81481696567249E8 | 2.12696235413058E8 | 2.13523563015262E8 | 1.92386583493888E8 | 2.00792310651879E8 | 2.022341523870097E8 | 3.0604731494329E8 | 2.72875123758133E8 | 2.45952285820886E8 | 2.7495824150743634E8 | 1.00071254189999E8 | 1.59531432686856E8 | 1.1928889459527E8 | 1.2629719382404166E8 |
| P11087 | Collagen alpha-1(I) chain [OS=Mus musculus] | 797.017 | 79 | 75 | 1933 | 35 | 1453 | 137.9 | cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12842 | ENSMUSG00000001506 | Col1a1 | mmu:12842; P11087; Q53WT0; Q60635; Q61367; Q61427; Q63919; Q6PCL3; Q810J9 | Osteoblast signaling; Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Comprehensive IL-17A signaling; Focal adhesion | Cell surface interactions at the vascular wall; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ECM proteoglycans; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; GPVI-mediated activation cascade; GP1b-IX-V activation signalling; Platelet Adhesion to exposed collagen; Platelet Aggregation (Plug Formation); MET activates PTK2 signaling | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 1.58880673198775E-4 | 0.381922652011049 | 0.0629214061377862 | 0.655833157547641 | 703080.609341466 | 1047026.5902454 | 567207.050774397 | 772438.0834537543 | 6.12803341835757E8 | 6.28616080368892E8 | 5.37143706349406E8 | 5.92854376184685E8 | 2.20652487774689E8 | 1.86114398805651E8 | 2.17194307013081E8 | 2.0798706453114033E8 | 9.46570689754052E7 | 9.72166914362706E7 | 6.09758172025116E7 | 8.428319253806247E7 | 4.84358218594371E7 | 7.06441702532683E7 | 6.01286898886734E7 | 5.973622733379293E7 |
| Q01149 | Collagen alpha-2(I) chain [OS=Mus musculus] | 773.662 | 80 | 66 | 1731 | 51 | 1372 | 129.5 | cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12843 | ENSMUSG00000029661 | Col1a2 | mmu:12843; Q01149; Q8CGA5 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Focal adhesion | Crosslinking of collagen fibrils; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; ECM proteoglycans; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; GPVI-mediated activation cascade; GP1b-IX-V activation signalling; Platelet Adhesion to exposed collagen; Platelet Aggregation (Plug Formation); MET activates PTK2 signaling | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.0150838661305169 | 0.862063111456553 | 0.0347692006632991 | 0.926292871155025 | 217896.573253055 | 102775.453905646 | 225868.955510701 | 182180.3275564673 | 3.82374533805921E8 | 3.80614155239716E8 | 2.79801552870279E8 | 3.475967473053053E8 | 1.73556920519588E8 | 1.55763113653521E8 | 1.89931753802048E8 | 1.7308392932505235E8 | 1.03217412397752E8 | 1.04517075360638E8 | 6.33578194684048E7 | 9.036410240893161E7 | 2.65479311979207E7 | 5.19818116295111E7 | 4.96147162399626E7 | 4.271481968913147E7 |
| P08121 | Collagen alpha-1(III) chain [OS=Mus musculus] | 695.631 | 63 | 61 | 1789 | 51 | 1464 | 138.9 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | extracellular matrix;other cell component | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 12825 | ENSMUSG00000026043 | Col3a1 | mmu:12825; P08121; Q61429; Q9CRN7 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Focal adhesion | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ECM proteoglycans; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; MET activates PTK2 signaling | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.00738207855214502 | 0.0413994480640273 | 0.394949139624895 | 0.976852696203657 | 619884.023482232 | 468692.52789102 | 275667.802679115 | 454748.1180174556 | 2.79020579584843E8 | 2.94236692581693E8 | 2.78582579285209E8 | 2.8394661715058166E8 | 6.51340156000414E7 | 5.70632610319163E7 | 6.62894421161806E7 | 6.282890624937943E7 | 7.54516142044654E7 | 7.68700494785543E7 | 4.61499837269909E7 | 6.6157215803336866E7 | 2.39448217703501E7 | 3.64849658219652E7 | 3.06665885804687E7 | 3.0365458724261332E7 |
| Q9QXS1 | Plectin [OS=Mus musculus] | 659.702 | 46 | 182 | 1705 | 180 | 4691 | 533.9 | cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component | cytoskeletal activity;other molecular function | 18810 | ENSMUSG00000022565 | Plec | E9QN87; mmu:18810; Q6S384; Q6S389; Q6S394; Q9CS65; Q9QUT2; Q9QXQ8; Q9QXQ9; Q9QXR0; Q9QXR1; Q9QXR2; Q9QXR3; Q9QXR4; Q9QXR5; Q9QXR6; Q9QXR7; Q9QXR8; Q9QXR9; Q9QXS0; Q9QXS1; Q9QXS2; Q9QXS3 | Alpha 6 beta 4 integrin signaling pathway; EGFR1 signaling pathway | Type I hemidesmosome assembly; Caspase-mediated cleavage of cytoskeletal proteins | 0.481729871164266 | 0.714932595871944 | 0.336550483871782 | 0.572524806937582 | 0.850917681937748 | 0.532399788858771 | 0.702330308974487 | 0.520376293994664 | 307407.817065559 | 282192.990008148 | 340166.735457239 | 309922.514176982 | 1.95783440606639E7 | 1.89230076526173E7 | 1.15266683074569E7 | 1.6676006673579365E7 | 3962115.44279651 | 3474477.32513512 | 6361226.57462356 | 4599273.114185064 | 5.1842207663806E7 | 4.48709077668655E7 | 3.18339270889303E7 | 4.28490141732006E7 | 7604177.6415354 | 1.18325057871337E7 | 1.10137014373925E7 | 1.01501282886872E7 |
| P08122 | Collagen alpha-2(IV) chain [OS=Mus musculus] | 526.992 | 64 | 69 | 1077 | 69 | 1707 | 167.2 | RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix | extracellular structural activity | 12827 | ENSMUSG00000031503 | Col4a2 | mmu:12827; P08122; Q3B7C2; Q3TPV9; Q61375; Q66JS5; Q6RCT6; Q6RCT7; Q6U9X1; Q8BPI9; Q8BPK3; Q91VI3 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Focal adhesion | Laminin interactions; Signaling by PDGF; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions | 0.352816378116182 | 0.64759425713406 | 0.293387877727491 | 0.79866917976589 | 0.979628232635575 | 0.169673447599406 | 0.959159975702413 | 0.483015668880262 | 1499335.01530309 | 1691518.00623855 | 989751.415380184 | 1393534.8123072747 | 5.53234274481973E7 | 5.88619201086468E7 | 3.63990683013196E7 | 5.0194805286054574E7 | 1.35123643610626E7 | 1.30555597235297E7 | 1.53773176128868E7 | 1.3981747232493034E7 | 6.80333035906639E7 | 6.55922447276284E7 | 4.55601360762201E7 | 5.972856146483746E7 | 9511844.25395737 | 2.43703078917008E7 | 1.71661195678148E7 | 1.701609057115766E7 |
| Q3U962 | Collagen alpha-2(V) chain [OS=Mus musculus] | 518.514 | 64 | 57 | 817 | 55 | 1497 | 144.9 | cell organization and biogenesis;developmental processes;other biological processes | extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12832 | ENSMUSG00000026042 | Col5a2 | mmu:12832; Q3TVR2; Q3U962; Q3UHK7; Q3UTT4; Q3V1J6; Q61431; Q7TMS0; Q80VS8 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions | 0.861384746267066 | 0.961254912149485 | 0.730324052254867 | 0.632833892117728 | 0.0769666553885184 | 0.273444295895674 | 0.453486790198347 | 0.973358018692255 | 1.96082795853326E7 | 1.89754303457921E7 | 3.46758133166589E7 | 2.4419841082594533E7 | 4.80275081428664E7 | 4.79991185130461E7 | 4.1747532446715E7 | 4.592471970087584E7 | 1.59204573672189E7 | 1.42782577106181E7 | 1.7061559679881E7 | 1.5753424919239333E7 | 2.09575588581227E7 | 1.96948053072084E7 | 2.25862916575107E7 | 2.1079551940947264E7 | 4881772.8383399 | 8018525.34642114 | 1.85137908486988E7 | 1.0471363011153279E7 |
| Q05793 | Basement membrane-specific heparan sulfate proteoglycan core protein [OS=Mus musculus] | 507.28 | 33 | 84 | 998 | 84 | 3707 | 398 | cell organization and biogenesis;transport;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;ER/Golgi | other molecular function | 15530 | Hspg2 | mmu:15530; Q05793 | 0.332090710292395 | 0.382764581022518 | 0.771134174410141 | 0.553652046981626 | 0.208890689478245 | 0.938381933295379 | 0.285967432697218 | 0.908661395894721 | 136795.508290338 | 206406.403199821 | 169825.859706297 | 171009.25706548532 | 3.70110206606215E7 | 4.34630743166815E7 | 4.28074794537461E7 | 4.109385814368304E7 | 2.41165287907714E7 | 1.91842080304052E7 | 2.07659482289725E7 | 2.1355561683383033E7 | 2.10452863152835E7 | 2.06741361608803E7 | 1.52751209810576E7 | 1.8998181152407136E7 | 5927226.99682882 | 1.0580617159021E7 | 8226367.86740312 | 8244737.341084313 | |||
| Q61554 | Fibrillin-1 [OS=Mus musculus] | 499.202 | 38 | 86 | 1117 | 86 | 2873 | 312.1 | cell adhesion;other metabolic processes;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 14118 | ENSMUSG00000027204 | Fbn1 | A2AQ53; mmu:14118; Q60826; Q61554 | Comprehensive IL-17A signaling | Integrin cell surface interactions; Degradation of the extracellular matrix; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; TGF-beta receptor signaling activates SMADs; Molecules associated with elastic fibres | 0.0596853092747711 | 0.0840496117897429 | 0.378389090130589 | 0.84258396038376 | 0.087482121441914 | 0.862063111456553 | 0.0455630470425967 | 0.77820123247099 | 95282.9912894267 | 109686.773968107 | 40225.7464170883 | 81731.837224874 | 5.82457893686458E7 | 6.62931141873392E7 | 3.19536333419291E7 | 5.216417896597137E7 | 2.33066180631659E7 | 1.9035713753758E7 | 2.29784126659734E7 | 2.17735814942991E7 | 2.39841959808407E7 | 2.29999435869113E7 | 1.54925740961197E7 | 2.082557122129057E7 | 2575605.08863811 | 7345083.32475891 | 5514536.56061601 | 5145074.9913376765 |
| Q8BTM8 | Filamin-A [OS=Mus musculus] | 493.069 | 49 | 91 | 915 | 83 | 2647 | 281 | cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;other molecular function | 192176 | ENSMUSG00000031328 | Flna | B7FAV0; O54934; Q7TQI1; Q8BLK1; Q8BTM8; Q8BTN7; Q8VHX5; Q8VHX8; Q99KQ2 | Mapk signaling pathway; Focal adhesion | Platelet degranulation ; Cell-extracellular matrix interactions; RHO GTPases activate PAKs; GP1b-IX-V activation signalling | 0.0844935092512095 | 0.493514006575528 | 0.170420349138264 | 0.67528135146603 | 0.946239447314336 | 0.864215513767001 | 0.904360680536565 | 0.8468455705593 | 223080.302738683 | 192779.021360071 | 239583.24348992 | 218480.8558628913 | 1.21506602248127E7 | 1.23160583881327E7 | 9719435.76620134 | 1.1395384793048913E7 | 4325195.00464495 | 4176073.86658823 | 6355593.34436329 | 4952287.405198824 | 1.73054238441738E7 | 1.42527501066511E7 | 1.24998953996761E7 | 1.4686023116833666E7 | 2879720.55833739 | 5479053.39146785 | 4531038.34565544 | 4296604.098486893 |
| P02463 | Collagen alpha-1(IV) chain [OS=Mus musculus] | 487.707 | 70 | 68 | 828 | 68 | 1669 | 160.6 | cell organization and biogenesis;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix | extracellular structural activity;other molecular function | 12826 | ENSMUSG00000031502 | Col4a1 | mmu:12826; P02463; Q3UHJ4; Q3UJE7; Q3UQV2; Q53X35; Q6GQS7; Q6PHB5; Q99LQ8 | Spinal cord injury; Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Laminin interactions; Signaling by PDGF; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions | 0.604225174343649 | 0.68008321917751 | 0.284160251285083 | 0.936818656936794 | 0.483508479481234 | 0.167300285011781 | 0.777395712279767 | 0.224623005929948 | 359769.877634713 | 285958.835932462 | 141085.539092917 | 262271.417553364 | 2.00868956379824E7 | 2.17854047157598E7 | 2.25190928918174E7 | 2.1463797748519864E7 | 4657081.16483192 | 4119739.1632835 | 5084724.84322114 | 4620515.057112186 | 3.91843343162395E7 | 3.69562703398771E7 | 2.33283395840594E7 | 3.3156314746725336E7 | 6193195.94075903 | 1.32557370999003E7 | 7286914.931104 | 8911949.32392111 |
| Q60847 | Collagen alpha-1(XII) chain [OS=Mus musculus] | 480.266 | 40 | 95 | 991 | 95 | 3120 | 340 | cell adhesion;developmental processes | other cell component | 12816 | ENSMUSG00000032332 | Col12a1 | mmu:12816; P70322; Q60847 | Assembly of collagen fibrils and other multimeric structures; Collagen chain trimerization; Collagen degradation | 0.0975092237649803 | 1.8644578313253E-17 | 0.344512840834051 | 0.162753188077458 | 0.119424004207039 | 0.101350980560035 | 0.0103905836841461 | 0.266844028199729 | 98450.5264125119 | 58090.3600627237 | 83999.6481680613 | 80180.17821443231 | 3.34408474370425E7 | 3.89438836318894E7 | 1.74727378978336E7 | 2.9952489655588504E7 | 5.74848700994307E7 | 4.49447732262548E7 | 5.27793485517261E7 | 5.1736330625803865E7 | 1.71723257401258E7 | 1.50709974901674E7 | 1.16453026750935E7 | 1.4629541968462234E7 | 6848854.24799245 | 1.38653609093446E7 | 1.0899125462023E7 | 1.0537780206453351E7 | ||
| Q8VDD5 | Myosin-9 [OS=Mus musculus] | 418.364 | 45 | 73 | 827 | 60 | 1960 | 226.2 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;stress response;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;other molecular function | 17886 | ENSMUSG00000022443 | Myh9 | mmu:17886; Q3UHT9; Q3UHU4; Q6KAN6; Q811I2; Q8VDD5 | Primary focal segmental glomerulosclerosis (FSGS) | RHO GTPases activate PAKs; Regulation of actin dynamics for phagocytic cup formation | 0.156498497144098 | 0.0382609387499984 | 0.118876667035285 | 0.15125389278925 | 0.87421335771164 | 0.916542675526027 | 0.91728043005175 | 0.990873516209569 | 107483.529676039 | 153800.887463573 | 39674.4269878413 | 100319.6147091511 | 8783012.74886087 | 9974545.70796386 | 5444477.78467149 | 8067345.413832072 | 4748384.28257292 | 4410554.6604061 | 6370665.87897293 | 5176534.940650649 | 2.10207699044932E7 | 2.09758895852136E7 | 1.72823293907493E7 | 1.9759662960152034E7 | 5517905.75659883 | 9476865.41359831 | 8538625.93793802 | 7844465.70271172 |
| Cont_P02453 | Collagen alpha-1(I) chain OS=Bos taurus OX=9913 GN=COL1A1 PE=1 SV=3 | 414.689 | 43 | 43 | 1208 | 4 | 1463 | 138.9 | cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | 282187 | ENSBTAG00000013103 | COL1A1 | bta:282187; P02453; Q3MHM2 | Inflammatory response pathway; Osteoblast signaling; Focal adhesion | Fibronectin matrix formation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Collagen degradation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; Collagen chain trimerization; GPVI-mediated activation cascade; Platelet Aggregation (Plug Formation); Platelet Adhesion to exposed collagen; GP1b-IX-V activation signalling | 0.800889767710788 | 0.579410556046386 | 0.58548007712969 | 0.839216523231753 | 0.067749585016969 | 0.848119069115724 | 0.108042253370914 | 0.0107964100780951 | 246464.336302772 | 276104.509600215 | 163058.776827813 | 228542.54091026666 | 4343807.62117337 | 4270443.00602544 | 3115927.46864821 | 3910059.36528234 | 3219828.72869598 | 3183952.03023541 | 3383679.40073467 | 3262486.7198886867 | 941743.224351002 | 1075861.66368366 | 756862.710693879 | 924822.5329095138 | 876331.391932507 | 1065336.29340721 | 1364509.18546901 | 1102058.9569362423 |
| Cont_P02769 | Albumin OS=Bos taurus OX=9913 GN=ALB PE=1 SV=4 | 390.555 | 81 | 57 | 7095 | 54 | 607 | 69.2 | stress response;other biological processes | non-structural extracellular;other cell component | nucleic acid binding activity;other molecular function | 280717 | ALB | A5PJX3; bta:280717; O02787; P02769; P04277; Q3SZR2 | 0.520832629933248 | 0.650544967914241 | 0.598172767155558 | 0.497906326712893 | 0.946568086066385 | 0.413798631523592 | 0.846117085258013 | 0.468531677746422 | 3.41035277502904E9 | 3.06531085647989E9 | 1.66716629813739E9 | 2.7142766432154403E9 | 2.0547979326133E9 | 2.37062763488737E9 | 2.78500610382043E9 | 2.4034772237737E9 | 3.09362764542436E9 | 2.55631644026836E9 | 3.07992745656962E9 | 2.9099571807541137E9 | 2.97814649224141E9 | 2.86277256421772E9 | 2.21144220575444E9 | 2.6841204207378564E9 | 2.22855277531216E9 | 3.25384623573346E9 | 1.66052966718895E9 | 2.38097622607819E9 | |||
| P01027 | Complement C3 [OS=Mus musculus] | 388.541 | 53 | 70 | 1148 | 62 | 1663 | 186.4 | cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular;other cell component | signal transduction activity or receptor binding;enzyme regulator activity | 12266 | ENSMUSG00000024164 | C3 | mmu:12266; P01027; Q61370; Q80XP1 | Complement activation, classical pathway; Tyrobp causal network in microglia; Comprehensive IL-17A signaling | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade; Neutrophil degranulation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; G alpha (i) signalling events; Peptide ligand-binding receptors; Alternative complement activation; Activation of C3 and C5 | 0.712660037675161 | 0.729783028721347 | 0.506101547380209 | 0.762068821001752 | 0.939492000987438 | 0.512232143465318 | 0.413470300505934 | 0.991722673088443 | 4040096.73815256 | 3926631.83282415 | 1843021.41157313 | 3269916.660849947 | 4.04154698805798E7 | 4.4896658832648E7 | 4.8335201547635E7 | 4.4549110086954266E7 | 1.80671896153384E7 | 1.47828809765086E7 | 1.7121367805152E7 | 1.6657146132333001E7 | 9.88883606977539E7 | 8.1974398309486E7 | 5.99376709525504E7 | 8.026680998659676E7 | 2.84159228355073E7 | 4.96444404075474E7 | 3.21393016835685E7 | 3.6733221642207734E7 |
| Cont_Q7SIH1 | Alpha-2-macroglobulin OS=Bos taurus OX=9913 GN=A2M PE=1 SV=2 | 370.864 | 53 | 56 | 1089 | 56 | 1510 | 167.5 | non-structural extracellular | enzyme regulator activity;other molecular function | 513856 | ENSBTAG00000018137 | A2M | A8E647; bta:513856; Q7SIH1 | IL-6 signaling pathway | 0.688450665125024 | 0.839052280267302 | 0.731111241255251 | 0.509007335932165 | 0.944154202827561 | 0.540124873725708 | 0.671798309985569 | 0.809503222445875 | 5.71770657169572E7 | 6.35766951637367E7 | 4.19549690627817E7 | 5.423624331449187E7 | 6.46032237401637E7 | 7.37926671048822E7 | 7.2164410166051E7 | 7.018676700369896E7 | 8.06000315293491E7 | 7.23429494984619E7 | 7.40068576999505E7 | 7.564994624258716E7 | 8.7810317845685E7 | 9.50258669209954E7 | 6.46884849507494E7 | 8.250822323914327E7 | 3.96461495018234E7 | 7.63451634810678E7 | 4.10565401116459E7 | 5.23492843648457E7 | ||
| Cont_Q29443 | Serotransferrin OS=Bos taurus OX=9913 GN=TF PE=2 SV=1 | 343.183 | 74 | 48 | 1709 | 46 | 704 | 77.7 | stress response;transport;other biological processes | non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle | other molecular function | 280705 | TF | bta:280705; Q0IIK2; Q29443 | 0.615274986253429 | 0.964709887217926 | 0.600414647182016 | 0.571407162236119 | 0.902231721267411 | 0.105569810421019 | 0.506704636011438 | 0.313748671859839 | 1.71679936327392E8 | 1.91001417946965E8 | 8.41149187199369E7 | 1.48932090998098E8 | 1.24867801818358E8 | 1.55146358811954E8 | 1.88178132242021E8 | 1.5606409762411097E8 | 2.69795837029218E8 | 2.21755859229163E8 | 2.04768415701638E8 | 2.32106703986673E8 | 1.81082969779594E8 | 1.61167381210782E8 | 1.45463022007429E8 | 1.6257112433260167E8 | 1.38609619584445E8 | 1.76572700073531E8 | 9.18433757916485E7 | 1.3567523181654152E8 | |||
| Cont_P07589 | Fibronectin OS=Bos taurus OX=9913 GN=FN1 PE=1 SV=4 | 337.517 | 26 | 47 | 923 | 11 | 2478 | 272 | cell adhesion;cell organization and biogenesis;stress response;developmental processes;other biological processes | non-structural extracellular | signal transduction activity or receptor binding;other molecular function | FN1 | P07589 | 0.714071857030863 | 0.525827426782658 | 0.94971810013306 | 0.802863674292211 | 0.553450172742796 | 0.634088329627404 | 0.35834247597224 | 0.281927255363179 | 142865.797461343 | 209169.389049115 | 146732.075795441 | 166255.75410196633 | 1055759.20189889 | 1052518.92691246 | 748231.640959004 | 952169.9232567847 | 927817.269350189 | 797644.80797335 | 782189.414628216 | 835883.8306505851 | 683356.768802769 | 735882.167003896 | 388557.285212602 | 602598.7403397557 | 334439.098432858 | 506951.879121439 | 606468.327162644 | 482619.7682389803 | ||||
| Q80X90 | Filamin-B [OS=Mus musculus] | 335.882 | 38 | 75 | 608 | 66 | 2602 | 277.7 | cell organization and biogenesis;stress response;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 286940 | ENSMUSG00000025278 | Flnb | E9QNV9; mmu:286940; Q80X90; Q8VHX4; Q8VHX7; Q99KY3 | ISG15 antiviral mechanism | 0.296944306247309 | 0.238365792894698 | 0.254729742039053 | 0.629546282386664 | 0.936411452199724 | 0.897564267605108 | 0.872448101434609 | 0.866446545996913 | 201569.562939035 | 74814.3999578854 | 187488.727848728 | 154624.23024854946 | 5908241.65562211 | 7025090.54357015 | 5213153.27323614 | 6048828.490809467 | 2307098.04671866 | 1545558.91097354 | 3200680.70273347 | 2351112.5534752235 | 8948631.41531232 | 7437294.37435051 | 6391778.7211006 | 7592568.170254476 | 1318356.62479586 | 2409815.97001446 | 1867290.64861647 | 1865154.4144755967 | |
| Cont_P35527 | Keratin, type I cytoskeletal 9 OS=Homo sapiens OX=9606 GN=KRT9 PE=1 SV=3 | 310.424 | 69 | 35 | 915 | 34 | 623 | 62 | cell organization and biogenesis;other biological processes | cytosol;cytoskeleton | cytoskeletal activity | 3857 | ENSG00000171403 | KRT9 | hsa:3857; O00109; P35527; Q0IJ47; Q14665 | Formation of the cornified envelope | 0.836660982916281 | 0.73072258897653 | 0.769556732848094 | 0.964570089320365 | 0.873609880131656 | 0.936669139837906 | 0.516448827835279 | 0.0110179641295352 | 3.00988862408693E7 | 2.22166955848562E7 | 3.53566605858277E7 | 2.9224080803851068E7 | 3.83413938796298E7 | 4.01115354911529E7 | 4.55013850626263E7 | 4.1318104811136335E7 | 3.25056930591839E7 | 3.99576081794461E7 | 2.50556157717982E7 | 3.250630567014273E7 | 4.79768166310243E7 | 2.93517742058567E7 | 7.69722436015544E7 | 5.1433611479478456E7 | 9.27838604678364E7 | 5.6604390657593E7 | 1.31711700890849E8 | 9.369998400542612E7 | |
| Cont_P04264 | Keratin, type II cytoskeletal 1 OS=Homo sapiens OX=9606 GN=KRT1 PE=1 SV=6 | 306.58 | 65 | 45 | 1774 | 36 | 644 | 66 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;other molecular function | 3848 | ENSG00000167768 | KRT1 | B2RA01; hsa:3848; P04264; P85925; P86104; Q14720; Q6GSJ0; Q9H298 | Corticotropin-releasing hormone signaling | Formation of the cornified envelope; Neutrophil degranulation; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.65780924735352 | 0.653826967689551 | 0.631165145316661 | 0.89629386854896 | 0.873609880131656 | 0.770634810212039 | 0.254077056479593 | 5.78940441291519E-5 | 1.31038801811221E8 | 1.49848314576813E8 | 1.81048519054156E8 | 1.5397854514739665E8 | 1.64179912336924E8 | 1.70861004616453E8 | 1.60803236136221E8 | 1.6528138436319932E8 | 1.32005397364365E8 | 1.61355773356369E8 | 1.09071204525108E8 | 1.3414412508194733E8 | 1.84835731298625E8 | 1.38277867637903E8 | 2.0582953187505E8 | 1.7631437693719265E8 | 3.95085049343759E8 | 3.00261678765842E8 | 6.47574942932283E8 | 4.476405570139613E8 |
| P06909 | Complement factor H [OS=Mus musculus] | 292.01 | 49 | 41 | 540 | 41 | 1234 | 139 | cell adhesion;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes | non-structural extracellular;plasma membrane;other membranes;mitochondrion;other cell component | other molecular function | 12628 | ENSMUSG00000026365 | Cfh | mmu:12628; P06909; Q6NZK3 | Regulation of Complement cascade | 0.205200089226065 | 0.0359547312524068 | 1.50457038391225E-17 | 0.329485122608543 | 0.678323397545056 | 0.532399788858771 | 0.750662231008662 | 0.443116920082088 | 45833.2314948132 | 5719.34924483144 | 127074.400703141 | 59542.32714759521 | 9199603.23733176 | 9631512.57691777 | 1.22513356989878E7 | 1.036081717107911E7 | 1.13946236540082E7 | 8948376.12127358 | 1.13575209573925E7 | 1.0566840244224759E7 | 3.40837407850627E7 | 2.84575354110008E7 | 2.55312981422866E7 | 2.9357524779450033E7 | 6857257.31092971 | 1.08034871236965E7 | 7658800.41775084 | 8439848.284125684 | |
| P16546 | Spectrin alpha chain, non-erythrocytic 1 [OS=Mus musculus] | 291.854 | 35 | 74 | 473 | 74 | 2472 | 284.4 | cell organization and biogenesis | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 20740 | ENSMUSG00000057738 | Sptan1 | A3KGU6; A3KGU8; P16546; Q8K380; Q9CT05 | FAS pathway and stress induction of HSP regulation | Neutrophil degranulation; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Interaction between L1 and Ankyrins; COPI-mediated anterograde transport; RHOU GTPase cycle; RHOV GTPase cycle; Caspase-mediated cleavage of cytoskeletal proteins | 0.958962194559628 | 0.786160319109602 | 0.611910908670005 | 0.890289034593217 | 0.929383260195332 | 0.771887919257916 | 0.870511801558508 | 0.852906094467594 | 889916.065158961 | 705414.766907556 | 458549.490375553 | 684626.7741473566 | 4175162.43226982 | 4600176.71769719 | 3155429.78771999 | 3976922.979229001 | 1301153.76848032 | 907755.21332001 | 2072924.21437361 | 1427277.73205798 | 9282178.93349268 | 8610756.12905297 | 6522130.81446154 | 8138355.29233573 | 1477626.07784989 | 2972528.81421804 | 2340149.67970916 | 2263434.85725903 |
| Cont_P13645 | Keratin, type I cytoskeletal 10 OS=Homo sapiens OX=9606 GN=KRT10 PE=1 SV=6 | 286.713 | 62 | 30 | 1322 | 20 | 584 | 58.8 | cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes | plasma membrane;cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;other molecular function | 3858 | ENSG00000186395 | KRT10 | hsa:3858; P13645; Q14664; Q8N175 | Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.600890052902075 | 0.490821286240141 | 0.561934876627864 | 0.941696908693733 | 0.829734761131295 | 0.880940844456856 | 0.246231694954624 | 2.55433624902191E-5 | 8.57039306780817E7 | 1.2308209015436E8 | 1.23973335952419E8 | 1.1091978559495355E8 | 1.09050331614224E8 | 1.30109606828786E8 | 1.02692161896587E8 | 1.13950700113199E8 | 8.73473050095944E7 | 1.23031831133367E8 | 7.19147674496861E7 | 9.409796786421584E7 | 1.29238189237995E8 | 9.43248217623685E7 | 1.03859326412487E8 | 1.0914077913761683E8 | 2.4676744393623E8 | 2.01230291385254E8 | 5.11249836753994E8 | 3.19749190691826E8 | |
| Cont_P35908 | Keratin, type II cytoskeletal 2 epidermal OS=Homo sapiens OX=9606 GN=KRT2 PE=1 SV=2 | 284.975 | 78 | 42 | 1022 | 32 | 639 | 65.4 | cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes | plasma membrane;cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;cytoskeletal activity | 3849 | ENSG00000172867 | KRT2 | hsa:3849; P35908; Q4VAQ2 | Formation of the cornified envelope | 0.499413631103761 | 0.411258958244596 | 0.544106843431104 | 0.933570718645937 | 0.912218866069753 | 0.862063111456553 | 0.309041843038519 | 2.9837536993241E-4 | 2.56957016834685E7 | 6.51011422173888E7 | 5.25056794690703E7 | 4.776750778997586E7 | 3.16465014359267E7 | 4.04662454773149E7 | 3.03458785296059E7 | 3.415287514761583E7 | 2.58420950665494E7 | 4.44581259999837E7 | 1.77732081549674E7 | 2.9357809740500167E7 | 3.88601529372083E7 | 2.41897353529024E7 | 4.54682916268081E7 | 3.617272663897294E7 | 6.73715830359901E7 | 6.38856203067551E7 | 9.79668081708945E7 | 7.640800383787991E7 | |
| Q62059 | Versican core protein [OS=Mus musculus] | 279.715 | 17 | 44 | 1073 | 44 | 3357 | 366.6 | cell adhesion;developmental processes | non-structural extracellular;extracellular matrix;other cell component | other molecular function | Vcan | Q62058; Q62059; Q9CUU0 | ECM proteoglycans; Glycosaminoglycan-protein linkage region biosynthesis; CS/DS degradation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; CS-GAG biosynthesis; DS-GAG biosynthesis | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.854305439376382 | 0.613304974369123 | 0.478009151463064 | 0.783304059803245 | 125473.726574878 | 146060.097046071 | 41031.8651630982 | 104188.56292801573 | 8.44868881898379E7 | 1.01917408783468E8 | 9.76252353450265E7 | 9.467651077277745E7 | 1.00104936351016E8 | 8.17450473009677E7 | 8.92610512588614E7 | 9.037034497028168E7 | 1.04839173391366E8 | 1.06605513712809E8 | 7.38631920533055E7 | 9.510262638582683E7 | 4.44571187520766E7 | 8.14544543672178E7 | 5.09261453344577E7 | 5.89459061512507E7 | |||
| P10493 | Nidogen-1 [OS=Mus musculus] | 275.191 | 43 | 42 | 852 | 42 | 1245 | 136.5 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | other molecular function | 18073 | ENSMUSG00000005397 | Nid1 | mmu:18073; P10493; Q3TKX9; Q8BQI3; Q8C3U8; Q8C9P6 | Laminin interactions; Degradation of the extracellular matrix | 1.65082956259427E-17 | 1.8644578313253E-17 | 0.251140212279038 | 0.461941385639594 | 0.013229256333524 | 0.604382524464811 | 1.0740690550749E-5 | 0.781368126060588 | 439897.722361698 | 266111.080129006 | 261357.080833752 | 322455.2944414853 | 1.30583493944604E8 | 1.41493313555848E8 | 1.08068734992402E8 | 1.2671518083095133E8 | 1.1764867041349E8 | 1.23903817347262E8 | 1.22059347123012E8 | 1.2120394496125467E8 | 3.85653673006923E7 | 3.40794335543811E7 | 2.32700802472122E7 | 3.1971627034095198E7 | 6809358.71273179 | 1.16807558295498E7 | 8950100.03941293 | 9146738.193898173 | |
| O88207 | Collagen alpha-1(V) chain [OS=Mus musculus] | 275.025 | 46 | 52 | 413 | 44 | 1838 | 183.6 | cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes | extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12831 | ENSMUSG00000026837 | Col5a1 | A3KGE3; mmu:12831; O88207; Q3UG94; Q6F6B0 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | ECM proteoglycans; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; MET activates PTK2 signaling | 1.65082956259427E-17 | 1.8644578313253E-17 | 0.268653947705267 | 0.311207075116757 | 0.189625712887896 | 0.848119069115724 | 0.302671730722046 | 0.809503222445875 | 12502.6007438316 | 105962.872602761 | 122701.039249758 | 80388.83753211687 | 8585864.47184676 | 9052435.86465399 | 8047799.6262338 | 8562033.320911517 | 3715509.90739661 | 3183478.03245453 | 3834509.14396516 | 3577832.3612721 | 3548034.64380386 | 3694879.64301103 | 2052789.86607006 | 3098568.0509616495 | 910135.702053452 | 1926767.56075777 | 1322438.93167649 | 1386447.3981625708 |
| P37889 | Fibulin-2 [OS=Mus musculus] | 269.894 | 43 | 37 | 791 | 37 | 1221 | 131.7 | other biological processes | non-structural extracellular | other molecular function | 14115 | ENSMUSG00000064080 | Fbln2 | G5E8B3; mmu:14115; P37889; Q9WUI2 | Molecules associated with elastic fibres | 1.65082956259427E-17 | 0.0640195441309023 | 0.201227492083465 | 0.255240026777032 | 0.453005417011507 | 0.803447472095846 | 0.290132264062119 | 0.809503222445875 | 404936.27628206 | 303410.824570497 | 379728.902265123 | 362692.0010392267 | 7.35240092421165E7 | 8.16716617206073E7 | 8.54486063918813E7 | 8.021475911820169E7 | 7.34239875271171E7 | 6.18846762513378E7 | 6.13955038440774E7 | 6.556805587417743E7 | 5.64407337496573E7 | 5.35180097543675E7 | 3.80873889057723E7 | 4.93487108032657E7 | 2.21115750486307E7 | 3.84218730879294E7 | 2.96696416762988E7 | 3.00676966042863E7 | |
| Q8VHX6 | Filamin-C [OS=Mus musculus] | 249.498 | 31 | 65 | 425 | 56 | 2726 | 290.9 | cell organization and biogenesis;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity | 68794 | ENSMUSG00000068699 | Flnc | B2RY80; B9EKT2; mmu:68794; Q6PAI6; Q8VHX6; Q9JJ38 | Cell-extracellular matrix interactions | 0.562594032195739 | 0.719627996749639 | 0.962331548063155 | 0.57290809187594 | 0.976873891151678 | 0.96786708205164 | 0.933437821008547 | 0.80954066750699 | 362673.376414211 | 453714.7830589 | 401875.758519269 | 406087.97266412666 | 2896613.16388353 | 1997446.07055639 | 1374740.24453431 | 2089599.8263247435 | 898320.393102247 | 899851.262035181 | 1251187.76236098 | 1016453.1391661359 | 4619845.64928082 | 4224920.76413233 | 4533386.9985568 | 4459384.47065665 | 1245417.60281572 | 1275359.84004796 | 889222.28002913 | 1136666.5742976035 | |
| Q04857 | Collagen alpha-1(VI) chain [OS=Mus musculus] | 248.981 | 44 | 33 | 588 | 33 | 1025 | 108.4 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component | other molecular function | 12833 | ENSMUSG00000001119 | Col6a1 | mmu:12833; Q04857 | ECM proteoglycans; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Signaling by PDGF; NCAM1 interactions | 0.2534363617947 | 0.392208211277376 | 0.962331548063155 | 0.971216996811237 | 0.0353343473113635 | 0.97504218639442 | 0.115965329440656 | 0.380888676065133 | 99442.7570537982 | 67304.0023261046 | 63848.8638629308 | 76865.2077476112 | 6.50338448192604E7 | 8.11264443817216E7 | 6.12675161034549E7 | 6.914260176814564E7 | 5.28406132873544E7 | 4.53711044962942E7 | 5.19951028566589E7 | 5.0068940213435836E7 | 2.08305860584001E7 | 2.24322225654869E7 | 1.63957751491443E7 | 1.9886194591010433E7 | 1.00181099527419E7 | 1.94360212112643E7 | 1.39653990737858E7 | 1.4473176745930666E7 | |
| Cont_Q2UVX4 | Complement C3 OS=Bos taurus OX=9913 GN=C3 PE=1 SV=2 | 247.154 | 39 | 55 | 851 | 47 | 1661 | 187.1 | cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular;other cell component | signal transduction activity or receptor binding;enzyme regulator activity | 280677 | ENSBTAG00000017280 | C3 | bta:280677; Q2KIZ4; Q2UVX4 | Complement and coagulation cascades; Complement activation, classical pathway | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Neutrophil degranulation; Peptide ligand-binding receptors; G alpha (i) signalling events; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade; Alternative complement activation; Activation of C3 and C5 | 0.615680953989958 | 0.798729234704005 | 0.573945385766997 | 0.506364847510615 | 0.87421335771164 | 0.291700662163587 | 0.591028379533681 | 0.448532796991499 | 1.66248121121728E7 | 1.69271139045693E7 | 1.05083515570206E7 | 1.4686759191254234E7 | 1.25526666866144E7 | 1.76991579704635E7 | 1.56235874907449E7 | 1.5291804049274266E7 | 1.80944158276855E7 | 1.82336027421103E7 | 1.90370193770683E7 | 1.84550126489547E7 | 1.87583360164926E7 | 1.78001813666833E7 | 1.18248646641963E7 | 1.6127794015790733E7 | 9025681.5960692 | 1.79617171787325E7 | 8899645.14317005 | 1.196234797265725E7 |
| Q62261 | Spectrin beta chain, non-erythrocytic 1 [OS=Mus musculus] | 244.684 | 30 | 61 | 398 | 61 | 2363 | 274.1 | cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 20742 | ENSMUSG00000020315 | Sptbn1 | A2AFU1; mmu:20742; Q3TEM7; Q5SQL8; Q5SQL9; Q62261; Q9QWJ7 | COPI-mediated anterograde transport; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; RHOU GTPase cycle; Interaction between L1 and Ankyrins; RHOV GTPase cycle | 0.69394578118832 | 0.776437620310661 | 0.693719649766064 | 0.831411077141515 | 0.937876734191067 | 0.86315143463057 | 0.664971370235365 | 0.953305976192702 | 373834.445440549 | 533726.562973047 | 569801.107945045 | 492454.03878621367 | 3103526.47805657 | 3181731.16602619 | 2477755.42998989 | 2921004.358024217 | 796281.087102098 | 609431.872132576 | 1356947.15467432 | 920886.7046363313 | 7745784.08821259 | 6610112.71623617 | 4897418.35730506 | 6417771.720584608 | 1743474.26371724 | 2723698.32906552 | 2432765.02616441 | 2299979.2063157237 | |
| Q640N1 | Adipocyte enhancer-binding protein 1 [OS=Mus musculus] | 239.707 | 38 | 34 | 648 | 34 | 1128 | 128.3 | protein metabolism;other biological processes | nucleus;other cell component | nucleic acid binding activity;other molecular function | 11568 | ENSMUSG00000020473 | Aebp1 | mmu:11568; O88442; Q3TVV5; Q3TWA7; Q3TX56; Q3TXB2; Q5NCI9; Q61281; Q640N1 | 0.269326617826563 | 0.0457359864845759 | 0.605387748357992 | 0.631359014803774 | 0.534291750451691 | 0.760992448481534 | 0.145805028390539 | 0.963436677882021 | 3560033.84712119 | 4696620.34449178 | 6275149.80645163 | 4843934.666021533 | 4.59930845855363E7 | 5.69735867783534E7 | 2.04646374454636E7 | 4.1143769603117764E7 | 3.80233154774145E7 | 4.02615711999708E7 | 4.03854487434811E7 | 3.9556778473622136E7 | 3.40966164303398E7 | 3.7490792004469E7 | 2.41166240785119E7 | 3.1901344171106894E7 | 1.40971982755857E7 | 2.68643149803103E7 | 1.4983671743246E7 | 1.8648394999714002E7 | ||
| P57780 | Alpha-actinin-4 [OS=Mus musculus] | 239.42 | 58 | 45 | 483 | 30 | 912 | 104.9 | cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes | cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 60595 | ENSMUSG00000054808 | Actn4 | mmu:60595; P57780 | Primary focal segmental glomerulosclerosis (FSGS) | Platelet degranulation | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 0.19149089837131 | 0.921882153462399 | 0.795351011232032 | 0.968364585136618 | 0.938282411159324 | 5221.79731213346 | 36578.541519335 | 20900.169415734228 | 9107610.67207618 | 1.00453975465233E7 | 1.03378326393571E7 | 9830280.285985528 | 5095419.11923033 | 3409382.50707632 | 5238186.41277381 | 4580996.01302682 | 1.31020350186557E7 | 1.2711162036506E7 | 9162046.18669404 | 1.1658414413951913E7 | 3002316.05426355 | 5816939.08777499 | 4501757.36231035 | 4440337.50144963 | |
| Q7TPR4 | Alpha-actinin-1 [OS=Mus musculus] | 235.529 | 54 | 42 | 511 | 27 | 892 | 103 | cell adhesion;cell organization and biogenesis;other biological processes | plasma membrane;other membranes;cytoskeleton;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function | 109711 | ENSMUSG00000015143 | Actn1 | mmu:109711; Q7TPR4 | Regulation of actin cytoskeleton; Integrin-mediated cell adhesion; Focal adhesion | Platelet degranulation ; RHOF GTPase cycle; RHOBTB2 GTPase cycle; RHOD GTPase cycle; Regulation of cytoskeletal remodeling and cell spreading by IPP complex components | 0.995554138371554 | 0.178726136005694 | 0.819280225722906 | 0.941696908693733 | 0.974207409660283 | 0.744084716394381 | 0.837231569641376 | 0.879972045955715 | 354073.059499792 | 209249.076355465 | 897084.460899514 | 486802.1989182571 | 5526121.35104279 | 6211867.70337129 | 6893436.45630869 | 6210475.170240924 | 2413615.48536692 | 1933168.81934458 | 3229981.90899851 | 2525588.7379033365 | 1.03807818109957E7 | 1.11771340173328E7 | 8282960.99949337 | 9946958.94260729 | 2797115.44078374 | 4939050.64701654 | 3416305.89125481 | 3717490.65968503 |
| P02468 | Laminin subunit gamma-1 [OS=Mus musculus] | 230.882 | 35 | 43 | 454 | 43 | 1607 | 177.2 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | Lamc1 | P02468 | 0.118212047511996 | 0.116315527815218 | 0.459134305737471 | 0.675951294045723 | 0.3041568870489 | 0.877818946381645 | 0.368062651583427 | 0.922276466908065 | 14325.5972836352 | 21883.5466161272 | 18104.5719498812 | 1.5357350900924E7 | 1.57310961044729E7 | 1.74335709018572E7 | 1.61740059690847E7 | 7496762.71625721 | 6775968.90045745 | 7708775.93718172 | 7327169.184632126 | 9245241.37337628 | 9035989.05815721 | 5573559.97495901 | 7951596.802164167 | 2368540.67041914 | 4605215.17131646 | 2765122.91380764 | 3246292.9185144133 | |||||
| Q91ZX7 | Prolow-density lipoprotein receptor-related protein 1 [OS=Mus musculus] | 230.497 | 15 | 57 | 519 | 56 | 4545 | 504.4 | other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;other molecular function | 16971 | Lrp1 | mmu:16971; Q61291; Q91ZX7; Q920Y4 | Statin pathway; Wnt signaling pathway | Scavenging of heme from plasma; Retinoid metabolism and transport | 1.65082956259427E-17 | 0.0181625429641231 | 0.133639440745791 | 0.150830220548111 | 0.687557067265551 | 0.925871264502428 | 0.74148782464906 | 0.901098484497789 | 10237.2255539891 | 51104.3489937616 | 30670.78727387535 | 6875342.47952318 | 6944806.90573824 | 8247481.69257335 | 7355877.025944923 | 4299652.1243919 | 2953538.60705284 | 3392031.85738558 | 3548407.5296101067 | 6405748.2654286 | 5854087.4911046 | 4914685.84613499 | 5724840.5342227295 | 1705219.62694462 | 2981142.11204421 | 2044471.2247951 | 2243610.9879279765 | ||
| Cont_P60712 | Actin, cytoplasmic 1 OS=Bos taurus OX=9913 GN=ACTB PE=1 SV=1 | 225.45 | 70 | 19 | 852 | 2 | 375 | 41.7 | cell organization and biogenesis;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component | enzyme regulator activity;cytoskeletal activity;other molecular function | 100033878; 100135470; 100173832; 101844587; 102139853; 11461; 118833809; 280979; 396526; 403580; 414396; 443052; 450133; 60; 81822 | ENSBTAG00000026199; ENSCAFG00000016020; ENSCAFG00030015381; ENSCAFG00040015695; ENSCPOG00000013467; ENSG00000075624; ENSMAUG00000008763; ENSMUSG00000029580; ENSOARG00040012985; ENSOARG00180022443; ENSOARG00185023855; ENSOARG00215030140; ENSOARG00225009314; ENSPPYG00000017336; ENSPTRG00000018890; ENSRNOG00000034254; ENSSSCG00000007585; ENSSSCG00030003451; ENSSSCG00035038792; ENSSSCG00040049462; ENSSSCG00045027458; ENSSSCG00050065025; ENSSSCG00055012597; ENSSSCG00060019124; ENSSSCG00065037921; ENSSSCG00070011353; ENSSSCG00105030144; ENSSSCG00110026965; ENSSSCG00115013637; ENSSSCG00130033784 | Actb; ACTB | A5D961; A5PKA1; bta:280979; cfa:403580; cpoc:100135470; csab:103246953; ecb:100033878; gga:396526; hsa:60; maua:101844587; mmu:11461; O18840; oas:443052; P02570; P60706; P60707; P60708; P60709; P60710; P60711; P60712; P60713; P70514; P99021; pon:100173832; ptr:450133; Q11209; Q11211; Q3SZD2; Q3TI89; Q3TVP6; Q4L0Y2; Q4R561; Q5R1X3; Q5R582; Q5R6G0; Q64316; Q6QAQ1; Q6ZWM3; Q711N9; Q71FK5; Q75MN2; Q76N69; Q8MIJ0; Q8SPX4; Q95164; Q96B34; Q96HG5; rno:81822; ssc:414396 | FAS pathway and stress induction of HSP regulation; Actin cytoskeleton regulation; Myometrial relaxation and contraction pathways; Focal adhesion; Arrhythmogenic right ventricular cardiomyopathy; Pathogenic Escherichia coli infection; Common pathways underlying drug addiction; Myometrial relaxation and contraction pathways; Focal adhesion; Fas ligand pathway and stress induction of heat shock proteins; Pathogenic Escherichia coli infection; Arrhythmogenic right ventricular cardiomyopathy; Focal adhesion; Myometrial relaxation and contraction pathways; Regulation of actin cytoskeleton; Myometrial relaxation and contraction pathways; Ebola virus infection in host; Acute viral myocarditis; Thermogenesis; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Overlap between signal transduction pathways contributing to LMNA laminopathies; Pleural mesothelioma; Regulation of actin cytoskeleton; Network map of SARS-CoV-2 signaling; Regulation of actin cytoskeleton; Regulation of actin cytoskeleton; Focal adhesion | Formation of the canonical BAF (cBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); Regulation of actin dynamics for phagocytic cup formation; EPH-ephrin mediated repulsion of cells; Formation of annular gap junctions; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; RHO GTPases Activate Formins; RHOF GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; B-WICH complex positively regulates rRNA expression; Regulation of CDH1 Function; Formation of the dystrophin-glycoprotein complex (DGC); Formation of the canonical BAF (cBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); RHO GTPases Activate WASPs and WAVEs; UCH proteinases; DNA Damage Recognition in GG-NER; Formation of the non-canonical BAF (ncBAF) complex; RHO GTPases activate IQGAPs; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Cell-extracellular matrix interactions; MAP2K and MAPK activation; Interaction between L1 and Ankyrins; RHOF GTPase cycle; DNA Damage Recognition in GG-NER; MAP2K and MAPK activation; RHO GTPases Activate Formins; Clathrin-mediated endocytosis; UCH proteinases; RHOF GTPase cycle; DNA Damage Recognition in GG-NER; EPH-ephrin mediated repulsion of cells; VEGFA-VEGFR2 Pathway; Regulation of actin dynamics for phagocytic cup formation; Adherens junctions interactions; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); RHO GTPases Activate WASPs and WAVEs; B-WICH complex positively regulates rRNA expression; Regulation of CDH1 Function; EPHB-mediated forward signaling; Formation of the non-canonical BAF (ncBAF) complex; Formation of the canonical BAF (cBAF) complex; Formation of annular gap junctions; RHO GTPases activate IQGAPs; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; RHO GTPases Activate WASPs and WAVEs; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RHO GTPases activate IQGAPs; RHO GTPases Activate Formins; RHOF GTPase cycle; Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs); B-WICH complex positively regulates rRNA expression; Signaling by BRAF and RAF1 fusions; UCH proteinases; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; VEGFA-VEGFR2 Pathway; Formation of the dystrophin-glycoprotein complex (DGC); Factors involved in megakaryocyte development and platelet production; Regulation of MITF-M-dependent genes involved in pigmentation; Formation of the canonical BAF (cBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); EPH-ephrin mediated repulsion of cells; HATs acetylate histones; Interaction between L1 and Ankyrins; Prefoldin mediated transfer of substrate to CCT/TriC; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Adherens junctions interactions; Regulation of CDH1 Function; Formation of the non-canonical BAF (ncBAF) complex; DNA Damage Recognition in GG-NER; Formation of the polybromo-BAF (pBAF) complex; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Formation of annular gap junctions; Folding of actin by CCT/TriC; Cell-extracellular matrix interactions; MAP2K and MAPK activation; RHO GTPases Activate Formins; Recycling pathway of L1; RHO GTPases activate IQGAPs; Clathrin-mediated endocytosis; Formation of the dystrophin-glycoprotein complex (DGC); EPHB-mediated forward signaling; UCH proteinases; B-WICH complex positively regulates rRNA expression; Adherens junctions interactions; Formation of the non-canonical BAF (ncBAF) complex; Formation of annular gap junctions; Formation of the polybromo-BAF (pBAF) complex; VEGFA-VEGFR2 Pathway; Cell-extracellular matrix interactions; RHO GTPases Activate WASPs and WAVEs; Regulation of CDH1 Function; Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; UCH proteinases; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); Formation of the polybromo-BAF (pBAF) complex; B-WICH complex positively regulates rRNA expression; DNA Damage Recognition in GG-NER; Formation of the canonical BAF (cBAF) complex; RHO GTPases Activate Formins; Regulation of CDH1 Function; Interaction between L1 and Ankyrins; RHOF GTPase cycle; Formation of the non-canonical BAF (ncBAF) complex; Adherens junctions interactions; Formation of the dystrophin-glycoprotein complex (DGC); VEGFA-VEGFR2 Pathway; RHO GTPases Activate WASPs and WAVEs; Cell-extracellular matrix interactions; EPHB-mediated forward signaling; MAP2K and MAPK activation; Recycling pathway of L1; RHO GTPases activate IQGAPs; Formation of annular gap junctions; B-WICH complex positively regulates rRNA expression; UCH proteinases; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); MAP2K and MAPK activation; Formation of the polybromo-BAF (pBAF) complex; RHO GTPases Activate Formins; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases Activate WASPs and WAVEs; Formation of the dystrophin-glycoprotein complex (DGC); VEGFA-VEGFR2 Pathway; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; DNA Damage Recognition in GG-NER; RHOF GTPase cycle; Cell-extracellular matrix interactions; Adherens junctions interactions; Formation of the non-canonical BAF (ncBAF) complex; Formation of the canonical BAF (cBAF) complex; RHO GTPases activate IQGAPs; Regulation of CDH1 Function; Gap junction degradation; Formation of annular gap junctions; Regulation of actin dynamics for phagocytic cup formation; RHOF GTPase cycle; Clathrin-mediated endocytosis; RHO GTPases Activate Formins; Cell-extracellular matrix interactions; VEGFA-VEGFR2 Pathway; Adherens junctions interactions; RHO GTPases activate IQGAPs; UCH proteinases; EPHB-mediated forward signaling; MAP2K and MAPK activation; RHO GTPases Activate WASPs and WAVEs; Formation of the dystrophin-glycoprotein complex (DGC); Formation of annular gap junctions; Formation of the canonical BAF (cBAF) complex; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of the non-canonical BAF (ncBAF) complex; Regulation of CDH1 Function | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.946568086066385 | 0.994348552930242 | 0.963278515868644 | 0.938282411159324 | 1924782.99006244 | 2098949.09709163 | 1966246.27612296 | 1996659.4544256767 | 6.9333476629433E7 | 7.92679608662888E7 | 4.66219167617927E7 | 6.5074451419171505E7 | 4.31411746831055E7 | 4.48147974340301E7 | 5.69102455002969E7 | 4.828873920581084E7 | 1.21577893646273E8 | 1.207324829685E8 | 8.72162161647777E7 | 1.0984219759318356E8 | 3.75040107769213E7 | 6.67519874410893E7 | 5.58171302270344E7 | 5.335770948168167E7 |
| P63260 | Actin, cytoplasmic 2 [OS=Mus musculus] | 217.791 | 70 | 19 | 831 | 2 | 375 | 41.8 | cell organization and biogenesis;stress response;developmental processes;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 11465 | ENSMUSG00000062825 | Actg1 | mmu:11465; P02571; P14104; P63260; P99022 | Myometrial relaxation and contraction pathways; Regulation of actin cytoskeleton; Focal adhesion | Platelet degranulation ; RHO GTPases activate IQGAPs; Adherens junctions interactions; Regulation of CDH1 Function; RHO GTPases Activate Formins; Regulation of actin dynamics for phagocytic cup formation; Interaction between L1 and Ankyrins; MAP2K and MAPK activation; Recycling pathway of L1; Clathrin-mediated endocytosis; Formation of the dystrophin-glycoprotein complex (DGC); EPHB-mediated forward signaling; RHOF GTPase cycle; Formation of annular gap junctions; VEGFA-VEGFR2 Pathway; Cell-extracellular matrix interactions; RHO GTPases Activate WASPs and WAVEs; RHOBTB2 GTPase cycle | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.85271451854395 | 0.901789796153066 | 0.731487178650893 | 0.819844267712751 | 345218.530665522 | 243712.893345201 | 175067.879334021 | 254666.434448248 | 138179.400499307 | 114235.784978709 | 184680.44906409 | 145698.54484736864 | 283414.957020267 | 357431.419092683 | 129167.257177683 | 256671.2110968777 | 47386.9835565671 | 139954.449837086 | 191405.076269325 | 126248.83655432604 | ||||
| P33434 | 72 kDa type IV collagenase [OS=Mus musculus] | 212.03 | 56 | 30 | 889 | 30 | 662 | 74.1 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes | extracellular matrix;plasma membrane;other membranes;cytoskeleton;mitochondrion;nucleus;other cell component | other molecular function | 17390 | ENSMUSG00000031740 | Mmp2 | mmu:17390; P33434 | Lung fibrosis; IL-3 signaling pathway; Matrix metalloproteinases | Collagen degradation; Extra-nuclear estrogen signaling; EPH-ephrin mediated repulsion of cells; Activation of Matrix Metalloproteinases | 0.372996577396536 | 0.964209443670126 | 0.342075680986172 | 0.708142491896103 | 0.993994198406889 | 0.459747209584207 | 0.34519376377552 | 0.809503222445875 | 1.45817945044039E7 | 3.99854546791863E7 | 2.31586213408419E7 | 2.5908623508144036E7 | 6.16168347215595E7 | 6.71128653428481E7 | 5.47627512450794E7 | 6.116415043649567E7 | 2.153095933586E7 | 2.04088973517033E7 | 2.1514079157928E7 | 2.11513119484971E7 | 9.59427020238632E7 | 8.49468673692442E7 | 8.11217362792938E7 | 8.73371018908004E7 | 3.5725700482165E7 | 6.85636819548367E7 | 5.65046943814106E7 | 5.359802560613743E7 |
| P19096 | Fatty acid synthase [OS=Mus musculus] | 203.372 | 23 | 48 | 335 | 48 | 2504 | 272.3 | other metabolic processes;stress response;other biological processes | plasma membrane;other membranes;cytosol;ER/Golgi;other cell component | other molecular function | 14104 | ENSMUSG00000025153 | Fasn | B1ATU8; mmu:14104; P19096; Q6PB72; Q8C4Z0; Q9EQR0 | Fatty acid biosynthesis; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-9 fatty acid synthesis; Elongation of (very) long chain fatty acids | Fatty acyl-CoA biosynthesis; Vitamin B5 (pantothenate) metabolism | 0.66189768147619 | 0.847457711018997 | 0.951921622352553 | 0.605074788683686 | 0.87421335771164 | 0.994834213681465 | 0.746782404466558 | 0.990873516209569 | 48161.514825801 | 157425.136778521 | 102793.32580216101 | 3018838.26514359 | 3331564.42510829 | 1838171.31939824 | 2729524.669883373 | 1125050.80259593 | 1067574.24276956 | 1976727.22395058 | 1389784.0897720233 | 3354008.01034064 | 3348654.9716265 | 2283763.91979924 | 2995475.6339221266 | 618361.207888453 | 1151575.74161029 | 908323.020723558 | 892753.3234074336 | |
| Cont_Q3SZ57 | Alpha-fetoprotein OS=Bos taurus OX=9913 GN=AFP PE=2 SV=1 | 202.89 | 62 | 30 | 1153 | 29 | 610 | 68.5 | other metabolic processes;developmental processes;other biological processes | non-structural extracellular;other cell component | other molecular function | 506011 | ENSBTAG00000017131 | AFP | bta:506011; Q3SZ57 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 0.540832988168188 | 0.82964085881652 | 0.605387748357992 | 0.553772240900005 | 0.938859506774495 | 0.15729598575093 | 0.699570390946254 | 0.323545662226049 | 4.4629857016799E7 | 4.39639700572647E7 | 2.72178105183923E7 | 3.8603879197485335E7 | 3.15168703669999E7 | 4.26075077823651E7 | 3.4328683389093E7 | 3.6151020512819335E7 | 4.8541823037709E7 | 4.32960721364381E7 | 4.4115949306695E7 | 4.5317948160280704E7 | 4.61564880446121E7 | 4.7548077639711E7 | 3.504265434565E7 | 4.2915740009991035E7 | 3.01476017178829E7 | 5.24042356620578E7 | 2.7823391939759E7 | 3.679174310656657E7 | |
| P48678 | Prelamin-A/C [OS=Mus musculus] | 202.607 | 60 | 37 | 529 | 36 | 665 | 74.2 | cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes | other membranes;cytoskeleton;nucleus;other cell component | other molecular function | 16905 | ENSMUSG00000028063 | Lmna | B3RH23; B3RH24; mmu:16905; P11516; P48678; P97859; Q3TIH0; Q3TTS8; Q3U733; Q3U7I5; Q3UCA0; Q3UCJ8; Q3UCU3; Q91WF2; Q9DC21 | Adipogenesis genes; FAS pathway and stress induction of HSP regulation | 1.65082956259427E-17 | 0.00670345592293191 | 0.139423967594304 | 1.70336894001643E-17 | 0.236076921565588 | 0.77212820363828 | 0.901149690306505 | 0.00692305873191716 | 56886.7483713492 | 69336.1384695612 | 100943.444664856 | 75722.11050192213 | 1.29312831685903E7 | 1.22006597313063E7 | 8045013.512583 | 1.1058985470826533E7 | 3337288.2268023 | 3262868.75019265 | 5804803.63611667 | 4134986.871037207 | 6.75536277126862E7 | 5.59333072922179E7 | 3.75993669940438E7 | 5.369543399964929E7 | 4234323.21548912 | 7210898.93259597 | 7422846.33935557 | 6289356.16248022 | |
| Q02788 | Collagen alpha-2(VI) chain [OS=Mus musculus] | 202.37 | 41 | 36 | 585 | 36 | 1034 | 110.3 | cell adhesion;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component | other molecular function | 12834 | ENSMUSG00000020241 | Col6a2 | mmu:12834; Q02788; Q05505; Q8C972; Q8K229 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | ECM proteoglycans; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation | 0.175734701097799 | 1.8644578313253E-17 | 0.633123216104285 | 0.767312384697355 | 0.156641881403766 | 0.880899056945259 | 0.0961283818482991 | 0.809503222445875 | 66343.4096791777 | 224638.480326659 | 72730.0086108415 | 121237.29953889274 | 5.06665581594054E7 | 6.05623117299827E7 | 4.51585075606234E7 | 5.21291258166705E7 | 4.3575871784427E7 | 3.72580130101725E7 | 4.32608904810994E7 | 4.136492509189963E7 | 2.4375983761655E7 | 2.22548052919965E7 | 1.51565723805374E7 | 2.0595787144729633E7 | 7758608.50160191 | 1.64425759910943E7 | 1.09937351728106E7 | 1.173163988850227E7 |
| P97927 | Laminin subunit alpha-4 [OS=Mus musculus] | 199.33 | 30 | 41 | 409 | 41 | 1816 | 201.7 | cell adhesion;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | signal transduction activity or receptor binding | 16775 | ENSMUSG00000019846 | Lama4 | mmu:16775; O88785; P70409; P97927; Q14BF2 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Formation of the dystrophin-glycoprotein complex (DGC); Laminin interactions; MET activates PTK2 signaling | 0.496649188935323 | 0.645007535999596 | 0.952104483873957 | 0.825047045401531 | 0.329011090732691 | 0.929291541980042 | 0.50594120050135 | 0.819844267712751 | 540030.170801593 | 370746.050286439 | 259459.878107817 | 390078.69973194966 | 8261193.64464048 | 1.06712284071143E7 | 1.21929154576081E7 | 1.037511250312096E7 | 5309597.35327991 | 4688186.1422195 | 5379156.74886131 | 5125646.74812024 | 6459712.32980478 | 5951943.81149588 | 4870147.4483696 | 5760601.1965567535 | 2775962.47504545 | 3878847.28463652 | 2541823.46940274 | 3065544.409694903 |
| P20152 | Vimentin [OS=Mus musculus] | 183.446 | 60 | 29 | 762 | 27 | 466 | 53.7 | cell organization and biogenesis;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component | cytoskeletal activity;nucleic acid binding activity;other molecular function | 22352 | ENSMUSG00000026728 | Vim | mmu:22352; O08704; P20152; Q8CCH1 | Spinal cord injury; Primary focal segmental glomerulosclerosis (FSGS); Alpha 6 beta 4 integrin signaling pathway | Aggrephagy; Striated Muscle Contraction; Caspase-mediated cleavage of cytoskeletal proteins; RHOBTB1 GTPase cycle | 1.65082956259427E-17 | 0.0955146622024883 | 1.50457038391225E-17 | 0.137621774180062 | 0.873609880131656 | 0.0297998664849654 | 0.840672080806375 | 0.0332723373064956 | 573727.34417641 | 968981.536762911 | 1794707.43115169 | 1112472.104030337 | 4.14069582585024E7 | 3.33312643886138E7 | 2.54656192896882E7 | 3.3401280645601466E7 | 6941733.99810384 | 6173483.46835617 | 8980531.63051753 | 7365249.698992513 | 8.80704815958352E7 | 8.07026224155391E7 | 5.51524218564722E7 | 7.464184195594883E7 | 6861556.37440952 | 1.68923991921504E7 | 1.5029979690535E7 | 1.292797841903164E7 |
| Q64727 | Vinculin [OS=Mus musculus] | 182.753 | 50 | 45 | 419 | 45 | 1066 | 116.6 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | plasma membrane;other membranes;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 22330 | ENSMUSG00000021823 | Vcl | mmu:22330; Q64727; Q8BP32; Q8BS46; Q922C5; Q922D9 | Primary focal segmental glomerulosclerosis (FSGS); IL-3 signaling pathway; Regulation of actin cytoskeleton; Integrin-mediated cell adhesion; Focal adhesion | Neutrophil degranulation; High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells; Platelet degranulation ; MAP2K and MAPK activation; Smooth Muscle Contraction; Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells; Regulation of CDH1 Function | 0.208404050858596 | 0.190838415616571 | 0.238791978742132 | 0.504745711776551 | 0.964629994744883 | 0.878264980963866 | 0.977491813528386 | 0.958518237573655 | 199164.849916128 | 87100.0128702587 | 92185.322880836 | 126150.06188907423 | 5675245.0989599 | 5838625.66584249 | 3008640.49360623 | 4840837.086136207 | 1870082.63283096 | 1414114.90526218 | 2577750.73562883 | 1953982.7579073233 | 7844023.43396073 | 7226639.25078312 | 5204108.91618431 | 6758257.200309387 | 1587883.53032107 | 3146179.30802337 | 2343388.9049214 | 2359150.5810886133 |
| Q8K4G1 | Latent-transforming growth factor beta-binding protein 4 [OS=Mus musculus] | 180.216 | 27 | 29 | 318 | 29 | 1666 | 178.5 | cell-cell signaling;cell organization and biogenesis;transport;signal transduction | non-structural extracellular;extracellular matrix | other molecular function | 108075 | ENSMUSG00000040488 | Ltbp4 | E9QPD9; mmu:108075; Q8K4G0; Q8K4G1 | TGF-beta receptor signaling activates SMADs; Molecules associated with elastic fibres | 0.308350896322176 | 0.362779483059131 | 1.50457038391225E-17 | 0.170566190602959 | 0.775297640004946 | 0.958956615096849 | 0.703189639676216 | 0.915193515309545 | 20541.0495723262 | 79596.1275426221 | 50068.58855747415 | 2657106.34177438 | 3398147.96764637 | 1365787.73467607 | 2473680.681365607 | 1578272.63307431 | 1205878.60177515 | 1625778.79640944 | 1469976.6770863 | 7998382.13678965 | 8274900.61088866 | 5600614.51816097 | 7291299.088613093 | 1154237.54308251 | 3609675.59166937 | 3209012.09868788 | 2657641.7444799202 | ||
| Q68FD5 | Clathrin heavy chain 1 [OS=Mus musculus] | 180.117 | 32 | 43 | 363 | 43 | 1675 | 191.4 | cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes | plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component | nucleic acid binding activity;other molecular function | 67300 | ENSMUSG00000047126 | Cltc | mmu:67300; Q68FD5 | IL-7 signaling pathway; Kit receptor signaling pathway | MHC class II antigen presentation; Recycling pathway of L1; Cargo recognition for clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis; LDL clearance; Retrograde neurotrophin signalling; Formation of annular gap junctions; Lysosome Vesicle Biogenesis; WNT5A-dependent internalization of FZD4; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation; RHOU GTPase cycle; RHOV GTPase cycle | 0.4248536990637 | 0.198232028950426 | 1.50457038391225E-17 | 0.413413145615294 | 0.688274955487563 | 0.840666598828607 | 0.946476383814868 | 0.835383236382767 | 19752.350121194 | 9410.067942265 | 14581.209031729499 | 2001079.20697008 | 2709198.63758679 | 1592899.41627153 | 2101059.0869428 | 1121542.74388673 | 1205380.43272811 | 1952895.490984 | 1426606.2225329466 | 7620271.96644723 | 6531411.29627789 | 6339405.19264676 | 6830362.818457293 | 1288866.59437226 | 2734753.66820203 | 2211269.42731124 | 2078296.563295177 | |
| P02469 | Laminin subunit beta-1 [OS=Mus musculus] | 179.863 | 27 | 40 | 429 | 39 | 1786 | 197 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;nucleus;other cell component | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 16777 | ENSMUSG00000002900 | Lamb1 | E9PXZ9; P02469 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Inflammatory response pathway; Alpha 6 beta 4 integrin signaling pathway; Focal adhesion | 0.205801242418232 | 0.341417478664423 | 0.526489846375643 | 0.891178501081124 | 0.269583968882479 | 0.900334730044572 | 0.356773085915651 | 0.98779298590131 | 1.07332672254E7 | 1.09845016908001E7 | 9663847.07936098 | 1.0460538665187027E7 | 1.70142446901215E7 | 1.73820787777271E7 | 2.08268192848537E7 | 1.8407714250900764E7 | 1.23074043806854E7 | 1.3842748821146E7 | 1.68288599063313E7 | 1.4326337702720901E7 | 1.20697658178524E7 | 1.33872705970957E7 | 9031275.37365186 | 1.149610392953332E7 | 2.54341447554609E7 | 1.6513199650281E7 | 2.12878061302996E7 | 2.1078383512013834E7 | |
| Q01853 | Transitional endoplasmic reticulum ATPase [OS=Mus musculus] | 179.055 | 52 | 32 | 411 | 32 | 806 | 89.3 | cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;other biological processes | other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;enzyme regulator activity;other molecular function | 269523 | ENSMUSG00000028452 | Vcp | mmu:269523; Q01853; Q3TFH9; Q3TIM2; Q3TXN9; Q6PI18; Q8BSR6; Q8CEG4 | IL-9 signaling pathway | RHOH GTPase cycle; Neutrophil degranulation; Protein methylation; Ovarian tumor domain proteases; Neddylation; ABC-family proteins mediated transport; Translesion Synthesis by POLH; Hedgehog ligand biogenesis; KEAP1-NFE2L2 pathway; HSF1 activation; N-glycan trimming in the ER and Calnexin/Calreticulin cycle; Josephin domain DUBs | 0.915230778358139 | 0.645007535999596 | 0.808626104853287 | 0.953867932777128 | 0.953038161729767 | 0.877818946381645 | 0.901149690306505 | 0.737824045087029 | 462345.280919521 | 876653.458620268 | 526426.850526767 | 621808.5300221853 | 1.01571081063743E7 | 9889323.38925712 | 7942233.31155878 | 9329554.935730066 | 4702185.44070802 | 4580279.55870278 | 6732778.24078372 | 5338414.413398174 | 1.50535993864462E7 | 1.350776734351E7 | 9751498.62422888 | 1.2770955118061693E7 | 3881002.94215154 | 5380991.32313934 | 4128956.06599177 | 4463650.11042755 |
| Q03350 | Thrombospondin-2 [OS=Mus musculus] | 178.303 | 35 | 30 | 328 | 29 | 1172 | 129.8 | cell adhesion;other biological processes | non-structural extracellular;extracellular matrix;other cell component | other molecular function | 21826 | ENSMUSG00000023885 | Thbs2 | mmu:21826; Q03350; Q8CG21 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Signaling by PDGF; O-glycosylation of TSR domain-containing proteins | 0.425958502904743 | 0.861805134687803 | 0.49027994509233 | 0.535702081245677 | 0.792896707923278 | 0.900334730044572 | 0.620448351319483 | 0.80954066750699 | 2258622.92192986 | 2382783.54746756 | 1148078.18193404 | 1929828.2171104867 | 1.31796330485542E7 | 1.5104624453426E7 | 5024405.63191042 | 1.1102887711296873E7 | 7531099.32555027 | 7013388.1367688 | 7773703.92822199 | 7439397.130180354 | 1.11743686938308E7 | 1.16923792648853E7 | 8892616.7561804 | 1.05864549049655E7 | 2163159.37338424 | 5673668.48605754 | 4798999.04450137 | 4211942.301314384 |
| Q80YX1 | Tenascin [OS=Mus musculus] | 175.9 | 28 | 43 | 191 | 43 | 2110 | 231.7 | cell adhesion;cell-cell signaling;cell organization and biogenesis;stress response;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | signal transduction activity or receptor binding;other molecular function | 21923 | ENSMUSG00000028364 | Tnc | mmu:21923; Q64706; Q80YX1; Q80YX2 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Integrin cell surface interactions; ECM proteoglycans; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 0.117980756369098 | 0.827773046590747 | 0.560799429150649 | 0.474732236495646 | 1.08858887903907E-8 | 0.00280630917527262 | 0.00972980877962454 | 0.46732263590517 | 11007.0641239407 | 22426.4186578027 | 29153.7668969926 | 20862.416559578665 | 1.62969685459921E7 | 1.53776908456905E7 | 4644794.12302626 | 1.2106484504902953E7 | 1608421.63729791 | 1232799.46655266 | 1507622.18059477 | 1449614.4281484466 | 244493.865771831 | 206768.885305398 | 181767.385360463 | 211010.04547923067 | 48104.5148614081 | 121500.029653831 | 119126.026959952 | 96243.5238250637 |
| Q61147 | Ceruloplasmin [OS=Mus musculus] | 175.43 | 36 | 33 | 380 | 33 | 1061 | 121.1 | cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular | other molecular function | 12870 | ENSMUSG00000003617 | Cp | mmu:12870; Q61147; Q6P5C8 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Iron uptake and transport; Metal ion SLC transporters | 1.65082956259427E-17 | 0.0286042496128814 | 0.232756100865398 | 0.470567140616547 | 0.114472406028442 | 0.902824569867946 | 0.217345018530886 | 0.830251457557488 | 174325.913751449 | 58856.3090021062 | 115033.849364799 | 116072.0240394514 | 9557281.19120236 | 1.04767827169696E7 | 8762702.67228452 | 9598922.193485493 | 5461844.00566682 | 4018732.98956624 | 4629071.77649001 | 4703216.257241024 | 4355240.25919752 | 3723693.63350954 | 2684226.57769155 | 3587720.1567995367 | 1720243.51649846 | 1992732.45731179 | 1556963.66647869 | 1756646.5467629798 | |
| Q3UQ28 | Peroxidasin homolog [OS=Mus musculus] | 173.636 | 35 | 39 | 366 | 39 | 1475 | 165 | cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes | extracellular matrix;ER/Golgi;other cell component | extracellular structural activity;other molecular function | 69675 | ENSMUSG00000020674 | Pxdn | A4FU83; E9QNQ9; mmu:69675; Q3UQ28 | Crosslinking of collagen fibrils | 0.121749369203589 | 0.199060935853007 | 0.481687712882875 | 0.64860195920101 | 0.414844709855988 | 0.680311384167738 | 0.622521206052951 | 0.910753558746772 | 41306.9360165718 | 84058.3874627107 | 31201.070658041 | 52188.79804577449 | 9910595.89492489 | 1.28240532958945E7 | 7690537.3381544 | 1.0141728842991263E7 | 3188445.14026578 | 3418561.86158515 | 3797799.58981602 | 3468268.863888983 | 6834484.53714744 | 5848987.74573488 | 4912888.48741006 | 5865453.59009746 | 743355.386480967 | 2642059.33003837 | 1858779.55214279 | 1748064.7562207088 | |
| Q61316 | Heat shock 70 kDa protein 4 [OS=Mus musculus] | 169.044 | 48 | 31 | 300 | 31 | 841 | 94.1 | protein metabolism;other metabolic processes | other cell component | other molecular function | Hspa4 | Q61316 | Regulation of HSF1-mediated heat shock response | 0.675982462193546 | 0.947627746595709 | 0.704651587991194 | 0.760498481134506 | 0.937908804051419 | 0.922660568001848 | 0.905946265571965 | 0.842404289073844 | 22434.4697799145 | 118934.685179003 | 13120.5332518918 | 51496.56273693644 | 3090247.7626811 | 3632683.19217962 | 4934376.07998548 | 3885769.0116153997 | 1752659.26658268 | 1094548.72984359 | 2299362.24833368 | 1715523.4149199834 | 6254897.5603188 | 4282912.67963475 | 3832568.37667092 | 4790126.20554149 | 1139246.15986255 | 2002609.64313824 | 1209098.21921722 | 1450318.0074060035 | |||
| Cont_P02533 | Keratin, type I cytoskeletal 14 OS=Homo sapiens OX=9606 GN=KRT14 PE=1 SV=4 | 164.831 | 58 | 26 | 684 | 9 | 472 | 51.5 | cell organization and biogenesis;other biological processes | plasma membrane;cytosol;cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 3861 | ENSG00000186847 | KRT14 | hsa:3861; P02533; Q14715; Q53XY3; Q9BUE3; Q9UBN2; Q9UBN3; Q9UCY4 | Corticotropin-releasing hormone signaling | Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin; Developmental Lineage of Mammary Gland Myoepithelial Cells; Type I hemidesmosome assembly | 0.821333803243143 | 0.880930298968675 | 0.666244110962191 | 0.887279041944908 | 0.735573385767802 | 0.728871118050286 | 0.645534074006669 | 1.76226512549596E-4 | 6033554.14310828 | 6671959.15781397 | 7782964.06135275 | 6829492.454091667 | 8837829.92566611 | 1.15627425945257E7 | 9278023.72116937 | 9892865.41378706 | 1.41062299354562E7 | 8950994.20838312 | 7841743.81261716 | 1.0299655985485494E7 | 1.15454726530467E7 | 7260451.91646668 | 9574113.2223773 | 9460012.597296894 | 2.05703168301172E7 | 1.34402077310531E7 | 5.39893889957522E7 | 2.9333304518974166E7 |
| P11499 | Heat shock protein HSP 90-beta [OS=Mus musculus] | 164.719 | 50 | 29 | 532 | 19 | 724 | 83.2 | cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component | enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function | 15516 | ENSMUSG00000023944 | Hsp90ab1 | mmu:15516; O89078; P11499; Q3UIQ7 | Focal adhesion: PI3K-Akt-mTOR signaling pathway | Neutrophil degranulation; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of actin dynamics for phagocytic cup formation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Attenuation phase; Estrogen-dependent gene expression; Sema3A PAK dependent Axon repulsion; Aryl hydrocarbon receptor signalling; DDX58/IFIH1-mediated induction of interferon-alpha/beta; HSF1 activation; RHOBTB2 GTPase cycle; The NLRP3 inflammasome | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.952333191127893 | 0.385192173946943 | 0.975071223710592 | 0.476079393565723 | 221410.585638305 | 129165.68527882 | 147525.692220339 | 166033.98771248801 | 3.34627647115336E7 | 3.61961534999558E7 | 2.61391308788083E7 | 3.193268303009924E7 | 9541203.16877468 | 9273367.56835581 | 1.36082703259873E7 | 1.0807613687705928E7 | 4.57710434253974E7 | 4.37708354854306E7 | 3.73056416942256E7 | 4.22825068683512E7 | 7437513.65495311 | 1.56244060515822E7 | 1.17622035416132E7 | 1.1608041082716169E7 |
| Q9JKF1 | Ras GTPase-activating-like protein IQGAP1 [OS=Mus musculus] | 163.926 | 28 | 36 | 250 | 36 | 1657 | 188.6 | cell organization and biogenesis;developmental processes;signal transduction;other biological processes | plasma membrane;other membranes;cytoskeleton;nucleus;other cell component | enzyme regulator activity;other molecular function | 29875 | ENSMUSG00000030536 | Iqgap1 | G3UW45; mmu:29875; Q9JKF1 | G13 signaling pathway; Regulation of actin cytoskeleton | RHO GTPases activate IQGAPs; Neutrophil degranulation; RAC1 GTPase cycle; RAC2 GTPase cycle; RHOA GTPase cycle; MAP2K and MAPK activation; RHOQ GTPase cycle; RHOC GTPase cycle; RHOU GTPase cycle; RHOV GTPase cycle; Nephrin family interactions | 0.930229675308081 | 0.794460986683881 | 0.787568130909409 | 0.991639536226218 | 0.830676695521175 | 0.941920360687835 | 0.777195460870953 | 0.924682711624237 | 49243.316732893 | 68725.418758499 | 58984.367745696 | 969026.209101501 | 1404075.03080168 | 833592.785314498 | 1068898.0084058929 | 204266.486982725 | 334218.990287697 | 455010.844725875 | 331165.4406654323 | 4213732.69874793 | 3933999.53801573 | 3238797.72524118 | 3795509.9873349466 | 503563.00444482 | 1468565.36197421 | 860307.289081776 | 944145.2185002686 | |
| P52480 | Pyruvate kinase PKM [OS=Mus musculus] | 163.393 | 62 | 27 | 442 | 27 | 531 | 57.8 | cell organization and biogenesis;other metabolic processes;other biological processes | cytosol;ER/Golgi;nucleus;other cell component | nucleic acid binding activity;kinase activity;other molecular function | 18746 | ENSMUSG00000032294 | Pkm | mmu:18746; P52480; Q3TBV8; Q3TBW5; Q3TC59; Q3U1X3; Q3U5P6; Q4VC20; Q64484; Q91YI8; Q9CWB1 | Glycolysis and gluconeogenesis; Purine metabolism | Neutrophil degranulation; Pyruvate metabolism; Glycolysis; Regulation of pyruvate metabolism | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.938859506774495 | 0.972868731003358 | 0.958705855138011 | 0.959522188921769 | 312569.127047718 | 79336.1029165598 | 280190.614862653 | 224031.9482756436 | 2.13357824001936E7 | 1.96436562290884E7 | 9081648.29120601 | 1.6687028973496003E7 | 1.01259485831113E7 | 9467201.29798786 | 1.55257573035923E7 | 1.1706302394897154E7 | 3.31547939620584E7 | 3.43565739025104E7 | 2.75852274417617E7 | 3.1698865102110166E7 | 7722776.69094361 | 1.86748082798887E7 | 1.43901632993649E7 | 1.3595916090065738E7 |
| P63017 | Heat shock cognate 71 kDa protein [OS=Mus musculus] | 161.557 | 53 | 28 | 572 | 23 | 646 | 70.8 | cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component | signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function | 15481 | ENSMUSG00000015656 | Hspa8 | mmu:15481; P08109; P12225; P63017; Q3U6R0; Q3U764; Q3U7D7; Q3U7E2; Q3U9B4; Q3U9G0; Q3UGM0; Q5FWJ6; Q62373; Q62374; Q62375; Q6NZD0 | Mapk signaling pathway; Exercise-induced circadian regulation | Neutrophil degranulation; mRNA Splicing - Major Pathway; Regulation of HSF1-mediated heat shock response; PKR-mediated signaling; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis; Attenuation phase; Lysosome Vesicle Biogenesis; GABA synthesis, release, reuptake and degradation; AUF1 (hnRNP D0) binds and destabilizes mRNA; Protein methylation | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.987939278265184 | 0.953011140807089 | 0.709593139419252 | 0.587315224195015 | 247063.168316828 | 221267.865667273 | 228333.997143376 | 232221.67704249235 | 2.34302361722569E7 | 1.91610816116977E7 | 2.44529780700925E7 | 2.2348098618015703E7 | 1.52458610795295E7 | 1.21057626921531E7 | 1.98188188374949E7 | 1.5723480869725833E7 | 4.35786305197153E7 | 3.523488629513E7 | 2.44125225303247E7 | 3.440867978172333E7 | 9679200.3009757 | 1.32405397257932E7 | 1.30838270231471E7 | 1.2001189016638666E7 |
| Q9JHU4 | Cytoplasmic dynein 1 heavy chain 1 [OS=Mus musculus] | 161.009 | 14 | 55 | 258 | 55 | 4644 | 531.7 | cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes | cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 13424 | ENSMUSG00000018707 | Dync1h1 | E9QM71; mmu:13424; Q9JHU4 | MHC class II antigen presentation; Neutrophil degranulation; Separation of Sister Chromatids; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; COPI-mediated anterograde transport; Recruitment of NuMA to mitotic centrosomes; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-independent Golgi-to-ER retrograde traffic; Aggrephagy; Anchoring of the basal body to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; AURKA Activation by TPX2 | 0.591873375996003 | 0.826895204418257 | 0.758743075163871 | 0.936818656936794 | 0.771389136401717 | 0.987352798667733 | 0.695927216301667 | 0.953305976192702 | 224060.75101347 | 288932.991027563 | 370866.333925136 | 294620.0253220563 | 1035717.43113769 | 1898525.78207622 | 892363.147243056 | 1275535.4534856554 | 298543.620628635 | 395801.785314415 | 659710.172961205 | 451351.8596347517 | 5741364.17159479 | 5412980.23144293 | 4332188.15134028 | 5162177.518126 | 1219184.02821873 | 1626625.47525789 | 1541170.38578568 | 1462326.6297541 | |
| Q99K41 | EMILIN-1 [OS=Mus musculus] | 157.011 | 31 | 21 | 244 | 21 | 1017 | 107.5 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 100952 | ENSMUSG00000029163 | Emilin1 | mmu:100952; Q99K41 | Molecules associated with elastic fibres | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.169879542413978 | 0.64186124184599 | 0.0921665663508908 | 0.491906845171331 | 6287128.66260445 | 6034831.78772075 | 4173278.84836641 | 5498413.09956387 | 1744058.35010072 | 1513530.29654839 | 1757558.94039384 | 1671715.86234765 | 2698540.13579468 | 2559754.7470142 | 1836473.80243277 | 2364922.89508055 | 286714.652107864 | 495091.120602366 | 371444.218276851 | 384416.66366236034 | |||||
| Q61879 | Myosin-10 [OS=Mus musculus] | 146 | 19 | 31 | 236 | 20 | 1976 | 228.9 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;nucleic acid binding activity;other molecular function | 77579 | ENSMUSG00000020900 | Myh10 | mmu:77579; Q5SV63; Q61879 | Regulation of actin cytoskeleton | RHO GTPases activate PAKs | 0.705689538076567 | 0.506231596289679 | 0.676239752697828 | 0.933545599871938 | 0.996007724449986 | 0.990096171400123 | 0.953146340313072 | 0.921444667457376 | 132922.802732814 | 81410.1821075416 | 155803.703539863 | 123378.89612673952 | 578601.376274227 | 569525.366217458 | 228469.06472958 | 458865.269073755 | 249877.75631 | 195698.454667987 | 352494.602688902 | 266023.60455562966 | 1222751.03080206 | 1020719.46631895 | 1025108.65415173 | 1089526.38375758 | 489393.525760184 | 539451.948957579 | 659882.564109888 | 562909.3462758837 |
| Cont_P00761 | Trypsin OS=Sus scrofa OX=9823 PE=1 SV=1 | 143.502 | 62 | 11 | 3859 | 10 | 231 | 24.4 | protein metabolism;other biological processes | non-structural extracellular | other molecular function | 0.254996071775817 | 0.172153475402034 | 0.357784551188889 | 0.34040294575649 | 0.822223648478518 | 0.740968241512781 | 0.960577895552113 | 0.148582186670595 | 5.17896971017178E9 | 5.13317471139103E9 | 7.27761160813741E9 | 5.863252009900073E9 | 2.70973552724487E9 | 1.73168232498425E9 | 2.0962236592694E9 | 2.1792138371661735E9 | 3.08554430734093E9 | 3.85764460784296E9 | 3.06099934235171E9 | 3.334729419178533E9 | 1.42194297351806E9 | 1.8379662886425E9 | 3.81973460995747E9 | 2.35988129070601E9 | 5.3849654871275E9 | 2.81761370832162E9 | 5.23567407489624E9 | 4.479417756781787E9 | ||||||
| P20029 | Endoplasmic reticulum chaperone BiP [OS=Mus musculus] | 142.966 | 48 | 25 | 434 | 23 | 655 | 72.4 | protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component | enzyme regulator activity;translation activity;other molecular function | 14828 | ENSMUSG00000026864 | Hspa5 | mmu:14828; O35642; P20029; Q3UFF2; Q61630 | Mapk signaling pathway | Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Regulation of HSF1-mediated heat shock response | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.916283277860523 | 0.769590657123576 | 0.985707795620743 | 0.888702680095366 | 7850142.93480902 | 7648809.53150357 | 9169945.31743656 | 8222965.927916382 | 7535475.80605118 | 5802650.52918468 | 8839942.11003441 | 7392689.481756757 | 1.89485602512479E7 | 1.6006905998567E7 | 1.24118184289709E7 | 1.57890948929286E7 | 7216046.0503345 | 9459779.49149077 | 8533209.24248049 | 8403011.594768586 | ||||
| Cont_P13647 | Keratin, type II cytoskeletal 5 OS=Homo sapiens OX=9606 GN=KRT5 PE=1 SV=3 | 142.395 | 51 | 34 | 500 | 20 | 590 | 62.3 | cell organization and biogenesis;other biological processes | cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;cytoskeletal activity;other molecular function | 3852 | ENSG00000186081 | KRT5 | hsa:3852; P13647; Q6PI71; Q6UBJ0; Q8TA91 | Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin; Developmental Lineage of Mammary Stem Cells; Developmental Lineage of Mammary Gland Myoepithelial Cells; Type I hemidesmosome assembly | 0.786915923361782 | 0.847457711018997 | 0.707170943024881 | 0.746833150482801 | 0.873755746039336 | 0.714156118974909 | 0.2733017775894 | 2.49132633766938E-5 | 5120503.46953844 | 5171426.92187225 | 6553368.21772984 | 5615099.536380176 | 9669299.63907403 | 1.1127930529353E7 | 9127716.50969809 | 9974982.226041706 | 9513581.76230213 | 7584977.17814252 | 6506980.60696686 | 7868513.182470503 | 1.59683716443188E7 | 1.28154121523541E7 | 1.32126695164861E7 | 1.3998817771053001E7 | 1.8678004759752E7 | 1.36191738010446E7 | 5.39600661696836E7 | 2.8752414910160065E7 | |
| Cont_P08779 | Keratin, type I cytoskeletal 16 OS=Homo sapiens OX=9606 GN=KRT16 PE=1 SV=4 | 140.751 | 54 | 25 | 569 | 12 | 473 | 51.2 | cell organization and biogenesis;stress response;other biological processes | plasma membrane;cytosol;cytoskeleton | cytoskeletal activity | 3868 | ENSG00000186832 | KRT16 | A8K488; hsa:3868; P08779; P30654; Q16402; Q9UBG8 | Vitamin D receptor pathway | Formation of the cornified envelope | 0.941324060398065 | 0.961351301268194 | 0.761460393544015 | 0.887279041944908 | 0.82543231800733 | 0.493923182294169 | 0.895302208460818 | 3.1065941501805E-4 | 1047544.82178002 | 1389728.97312405 | 1389730.63830375 | 1275668.1444026066 | 1501449.09449526 | 2307427.01338473 | 2939547.44501319 | 2249474.51763106 | 7196685.12946156 | 1715910.61220057 | 2812173.28112121 | 3908256.3409277797 | 4331979.12309994 | 1639569.64130669 | 1737373.70058763 | 2569640.8216647534 | 4434008.92515372 | 2223613.02167429 | 9547147.41410007 | 5401589.786976026 |
| Cont_P02465 | Collagen alpha-2(I) chain OS=Bos taurus OX=9913 GN=COL1A2 PE=1 SV=2 | 139.99 | 18 | 19 | 445 | 3 | 1364 | 129 | non-structural extracellular;extracellular matrix | extracellular structural activity;other molecular function | 282188 | ENSBTAG00000013472 | COL1A2 | A6QP13; bta:282188; O62649; P02465 | Inflammatory response pathway; Focal adhesion | Fibronectin matrix formation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Collagen degradation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; Collagen chain trimerization; GPVI-mediated activation cascade; Platelet Aggregation (Plug Formation); Platelet Adhesion to exposed collagen; GP1b-IX-V activation signalling | 0.483779141493222 | 0.876027096029978 | 0.421836754550416 | 0.488872343346086 | 0.731850662833984 | 0.076245756040016 | 0.549852418071669 | 0.432748651973214 | 80849.8235508145 | 93725.5578519836 | 35755.9745173747 | 70110.45197339094 | 170240.553800628 | 153570.468872413 | 167384.810476394 | 163731.944383145 | 78292.6458688874 | 70345.2867467554 | 108688.239366299 | 85775.39066064726 | 65032.7123193958 | 48396.6073357386 | 51482.0177898574 | 54970.44581499727 | 51011.1923790395 | 62191.0072542807 | 32903.9376967684 | 48702.045776696206 | |
| Cont_P12763 | Alpha-2-HS-glycoprotein OS=Bos taurus OX=9913 GN=AHSG PE=1 SV=2 | 132.772 | 50 | 16 | 1191 | 16 | 359 | 38.4 | stress response;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component | enzyme regulator activity | 280988 | AHSG | A6QLF7; bta:280988; P12763 | Neutrophil degranulation; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 0.573667790345329 | 0.793013134473823 | 0.624272910267193 | 0.36488675645736 | 0.946568086066385 | 0.268930374946741 | 0.335956814949331 | 0.913214993335179 | 6.75081036645858E8 | 9.56771805796805E8 | 4.32862555462728E8 | 6.882384659684638E8 | 6.04790296716478E8 | 6.42824998486085E8 | 6.76887564991134E8 | 6.41500953397899E8 | 8.54466282868744E8 | 8.4303805016043E8 | 9.16216503216691E8 | 8.712402787486216E8 | 7.41908408260606E8 | 7.48114705273509E8 | 6.29285280642112E8 | 7.064361313920757E8 | 3.42283489676807E8 | 6.64083343401506E8 | 3.25834950231514E8 | 4.440672611032756E8 | ||
| P07901 | Heat shock protein HSP 90-alpha [OS=Mus musculus] | 132.382 | 43 | 25 | 402 | 16 | 733 | 84.7 | cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component | signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function | 15519 | ENSMUSG00000021270 | Hsp90aa1 | mmu:15519; P07901 | EBV LMP1 signaling; Focal adhesion: PI3K-Akt-mTOR signaling pathway; IL-6 signaling pathway; IL-2 signaling pathway | Regulation of necroptotic cell death; Recruitment of NuMA to mitotic centrosomes; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of actin dynamics for phagocytic cup formation; Neutrophil degranulation; Downregulation of ERBB2 signaling; Anchoring of the basal body to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; AURKA Activation by TPX2; Extra-nuclear estrogen signaling; Attenuation phase; Estrogen-dependent gene expression; Sema3A PAK dependent Axon repulsion; VEGFR2 mediated vascular permeability; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation; DDX58/IFIH1-mediated induction of interferon-alpha/beta; eNOS activation; HSF1 activation; RHOBTB2 GTPase cycle; Drug-mediated inhibition of ERBB2 signaling | 1.65082956259427E-17 | 0.508730894200713 | 1.50457038391225E-17 | 0.251664970734015 | 0.974827674952665 | 0.788764875934969 | 0.968364585136618 | 0.745600589176001 | 51071.3130902855 | 169244.190500369 | 193833.457176882 | 138049.65358917884 | 3826029.08230807 | 4600695.96516161 | 3479662.10980986 | 3968795.71909318 | 1533159.7098775 | 1700635.66665037 | 1768278.53880507 | 1667357.9717776468 | 6471421.59388824 | 6122550.53993506 | 5450079.38924241 | 6014683.841021903 | 900341.190737514 | 2215799.13247972 | 1704183.40484156 | 1606774.576019598 |
| Q02819 | Nucleobindin-1 [OS=Mus musculus] | 131.152 | 51 | 21 | 299 | 21 | 459 | 53.4 | signal transduction | non-structural extracellular;other membranes;ER/Golgi | enzyme regulator activity;nucleic acid binding activity;other molecular function | 18220 | ENSMUSG00000030824 | Nucb1 | mmu:18220; Q02819; Q3TU42; Q9CWA1; Q9D8J4; Q9DBL3 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 0.130903496983571 | 0.0679830640731695 | 0.340647566778883 | 0.397987186613988 | 0.958122559708965 | 41072.7931792495 | 20198.6046706008 | 30635.69892492515 | 1.70846710933602E7 | 1.97547416617741E7 | 2.08807433533847E7 | 1.9240052036173E7 | 5757191.6972993 | 4828078.95450858 | 5895038.38978249 | 5493436.34719679 | 7136546.74332753 | 7387752.88718417 | 5120327.81590923 | 6548209.148806977 | 1130733.36645935 | 3369667.63744922 | 2637872.59598673 | 2379424.5332984333 | ||
| Q91V92 | ATP-citrate synthase [OS=Mus musculus] | 129.973 | 32 | 28 | 237 | 28 | 1091 | 119.7 | other metabolic processes | cytosol | other molecular function | 104112 | ENSMUSG00000020917 | Acly | mmu:104112; Q91V92 | Fatty acid biosynthesis | Neutrophil degranulation; Fatty acyl-CoA biosynthesis | 0.230775890814232 | 0.371468864113786 | 0.437429424171984 | 0.509570119936397 | 0.626059420687734 | 0.98558531112136 | 0.643183834410259 | 0.922580167429744 | 8856.99380706579 | 32765.2400642807 | 40990.0091117865 | 27537.414327710998 | 2382723.31982566 | 2481678.51703659 | 2154876.39410613 | 2339759.4103227933 | 1256305.5375454 | 885993.369046538 | 1688459.92743218 | 1276919.6113413726 | 2057502.05407172 | 1815562.79058184 | 1460220.9588277 | 1777761.9344937534 | 534991.757912276 | 802971.776166877 | 594587.914542531 | 644183.8162072281 |
| A2ASQ1 | Agrin [OS=Mus musculus] | 128.989 | 18 | 26 | 227 | 26 | 1950 | 207.4 | cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cell component | signal transduction activity or receptor binding;other molecular function | 11603 | ENSMUSG00000041936 | Agrn | A2ASP9; A2ASQ0; A2ASQ1; B2RWU1 | Primary focal segmental glomerulosclerosis (FSGS) | ECM proteoglycans; Retinoid metabolism and transport; Glycosaminoglycan-protein linkage region biosynthesis; HS-GAG biosynthesis; HS-GAG degradation; Formation of the dystrophin-glycoprotein complex (DGC) | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.460727828548759 | 0.972791368602389 | 0.686318824668434 | 0.846971399004193 | 2612028.52511147 | 3116500.52541199 | 3328171.1398056 | 3018900.06344302 | 1818519.74579979 | 1551006.46226864 | 1715477.48863677 | 1695001.2322350666 | 2313945.16119856 | 2044906.61336417 | 1778324.63596447 | 2045725.4701757336 | 632566.873707257 | 1496109.18442141 | 957812.214242183 | 1028829.4241236168 | ||||
| Q61508 | Extracellular matrix protein 1 [OS=Mus musculus] | 127.379 | 45 | 18 | 358 | 18 | 559 | 62.8 | stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular | signal transduction activity or receptor binding;other molecular function | 13601 | ENSMUSG00000028108 | Ecm1 | mmu:13601; Q3U5Q5; Q61508 | Platelet degranulation | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 0.121600547823456 | 2.27890527565265E-4 | 0.795351011232032 | 1.51989274634622E-7 | 0.592370654746194 | 110159.96586707 | 68619.5270607555 | 45654.6843175291 | 74811.39241511819 | 5.6443097497098E7 | 7.11751205740166E7 | 5.82782830048746E7 | 6.196550035866306E7 | 5.1935854689884E7 | 4.50204039942893E7 | 5.70225374161979E7 | 5.132626536679041E7 | 1.27540105597053E7 | 1.25514774649527E7 | 8690203.83604475 | 1.1331897286900917E7 | 2192350.97546663 | 4663417.73981907 | 3690111.31703252 | 3515293.344106073 | |
| Cont_P04259 | Keratin, type II cytoskeletal 6B OS=Homo sapiens OX=9606 GN=KRT6B PE=1 SV=5 | 126.901 | 47 | 30 | 442 | 4 | 564 | 60 | cell organization and biogenesis;other biological processes | cytosol;cytoskeleton | bone, tooth or skin structural activity;cytoskeletal activity | 3854 | ENSG00000185479 | KRT6B | hsa:3854; P04259; P48669 | Formation of the cornified envelope | 0.857251372850113 | 0.868132360832926 | 0.758743075163871 | 0.801271130817871 | 0.854305439376382 | 0.340133476321195 | 0.937453377971347 | 0.00123883404563536 | 267279.779286483 | 355493.362381868 | 274137.281616349 | 298970.1410949 | 326989.588402741 | 585438.697100962 | 617622.938974811 | 510017.07482617133 | 2390973.53573307 | 430931.486741926 | 646270.614315847 | 1156058.5455969477 | 1869779.42318807 | 346417.77494154 | 348508.009299423 | 854901.7358096777 | 1155463.67620058 | 538093.594898596 | 1653754.7898307 | 1115770.6869766254 | |
| P17182 | Alpha-enolase [OS=Mus musculus] | 126.804 | 60 | 19 | 244 | 16 | 434 | 47.1 | other metabolic processes;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;other cell component | nucleic acid binding activity;other molecular function | 13806; 433182 | ENSMUSG00000059040; ENSMUSG00000063524 | Eno1 | mmu:13806; mmu:433182; P17182; Q99KT7; Q9DCY7 | Glycolysis and gluconeogenesis | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.720832939248489 | 0.789540446904924 | 0.858218537342417 | 0.989544231571828 | 31098.019126098 | 70318.9502605952 | 40658.6319347469 | 47358.53377381337 | 1.28655809626545E7 | 1.34726279447959E7 | 7101469.5445256 | 1.1146559483992001E7 | 9089751.86845938 | 7552189.93174957 | 1.17772011823713E7 | 9473047.660860082 | 3.50544676757808E7 | 2.99447661492486E7 | 2.18255690502528E7 | 2.89416009584274E7 | 1.11532480577619E7 | 1.75489228796712E7 | 1.30151947674988E7 | 1.3905788568310633E7 | |
| P08113 | Endoplasmin [OS=Mus musculus] | 126.346 | 39 | 26 | 329 | 25 | 802 | 92.4 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cell component | signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function | 22027 | ENSMUSG00000020048 | Hsp90b1 | mmu:22027; P08113; P11427 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Hypoxia-dependent self-renewal of myoblasts | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Scavenging by Class A Receptors; Trafficking and processing of endosomal TLR; Interleukin-4 and Interleukin-13 signaling | 0.107476768049312 | 0.0104456807471941 | 1.50457038391225E-17 | 0.205304099107124 | 0.854305439376382 | 0.840785133352029 | 0.866766165039268 | 0.896996950298791 | 75656.6139115948 | 52183.5314261123 | 29905.9702816436 | 52582.03853978356 | 5932785.14172209 | 5786569.94317903 | 3299962.37110113 | 5006439.15200075 | 3817668.17887426 | 3366255.7650389 | 4907428.60350699 | 4030450.84914005 | 1.47606948013545E7 | 1.21020755462977E7 | 1.0441016038914E7 | 1.2434595462188734E7 | 3792376.91369813 | 7854793.82920015 | 6464144.86133097 | 6037105.20140975 |
| P58252 | Elongation factor 2 [OS=Mus musculus] | 126.048 | 37 | 31 | 378 | 30 | 858 | 95.3 | cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;translational apparatus;other cell component | cytoskeletal activity;translation activity;nucleic acid binding activity;other molecular function | 13629 | ENSMUSG00000034994 | Eef2 | mmu:13629; P58252; Q544E4 | Translation factors | Neutrophil degranulation; Protein methylation; Peptide chain elongation; Synthesis of diphthamide-EEF2 | 0.299809054080284 | 0.188334321166369 | 0.471929633209224 | 0.84258396038376 | 0.922179983282929 | 0.97504218639442 | 0.866546043492515 | 0.950878070645738 | 275529.241689771 | 247076.7728808 | 166294.142173825 | 229633.38558146535 | 1.22498155967913E7 | 1.26488626480754E7 | 6800245.14611723 | 1.0566307796994643E7 | 5717562.35282925 | 5172569.64432748 | 8352282.82529915 | 6414138.274151959 | 1.55667000517401E7 | 1.33925688878402E7 | 1.02378508629272E7 | 1.3065706600835832E7 | 2972661.18095993 | 6421886.97759523 | 5184391.52691505 | 4859646.5618234025 |
| Cont_P02538 | Keratin, type II cytoskeletal 6A OS=Homo sapiens OX=9606 GN=KRT6A PE=1 SV=3 | 123.757 | 47 | 30 | 454 | 3 | 564 | 60 | cell organization and biogenesis;stress response;other biological processes | cytosol;cytoskeleton | bone, tooth or skin structural activity;cytoskeletal activity | 3853 | ENSG00000205420 | KRT6A | A4QPC1; hsa:3853; P02538; P48667; Q08AR4; Q6NT67; Q96CL4 | Ectoderm differentiation; Ectoderm differentiation; Pancreatic cancer subtypes | Formation of the cornified envelope | 0.892533464536408 | 0.964633336683333 | 0.745886066139481 | 0.84258396038376 | 0.792564971776066 | 0.574739141583974 | 0.709593139419252 | 5.66461038960431E-4 | 2017098.82314832 | 2171650.09464557 | 2359880.73116726 | 2182876.549653717 | 2825309.68904382 | 4320098.03084773 | 4192074.59940388 | 3779160.7730984767 | 8075888.41129776 | 2685265.07688442 | 3594101.84504227 | 4785085.111074816 | 5878699.8667026 | 3215829.01184206 | 2854010.96069105 | 3982846.61307857 | 8158147.16608847 | 4198498.19802621 | 1.30998597349634E7 | 8485501.699692694 |
| P97298 | Pigment epithelium-derived factor [OS=Mus musculus] | 123.502 | 47 | 16 | 346 | 12 | 417 | 46.2 | cell cycle OR cell proliferation;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | enzyme regulator activity | 20317 | ENSMUSG00000000753 | Serpinf1 | mmu:20317; O70629; O88691; P97298 | 1.65082956259427E-17 | 0.227296093012204 | 0.434748506750565 | 0.770205086382264 | 0.00901230529014985 | 0.174886032348437 | 0.300753028734261 | 0.891044455497809 | 554016.1710638 | 470705.490372182 | 363015.858993357 | 462579.17347644636 | 5.24905837082578E7 | 7.20656975211191E7 | 8.90978835263609E7 | 7.121805491857927E7 | 1.55195541438312E7 | 1.33807646088142E7 | 1.504676823338E7 | 1.46490289953418E7 | 1.63245792137601E7 | 1.5700230598517E7 | 1.5246806329463E7 | 1.5757205380580032E7 | 3869051.7420588 | 8996988.40278734 | 4897006.93274029 | 5921015.69252881 | ||
| Q70E20 | Sushi, nidogen and EGF-like domain-containing protein 1 [OS=Mus musculus] | 122.942 | 19 | 22 | 287 | 22 | 1403 | 151.5 | cell adhesion | non-structural extracellular;extracellular matrix | other molecular function | 208777 | Sned1 | A6H6I3; mmu:208777; Q70E20; Q810H2; Q8BMD9 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.889058672589993 | 0.869908412860824 | 0.817293288705596 | 0.880760468933162 | 62940.5062355012 | 25184.2741656831 | 25459.8187779288 | 37861.533059704365 | 7879183.70581794 | 8304827.25748066 | 2617617.70526214 | 6267209.5561869135 | 3110990.0320528 | 3263544.92621848 | 3507274.08693078 | 3293936.3484006864 | 1.72480350493842E7 | 1.48489121993504E7 | 1.05732378776404E7 | 1.4223395042125002E7 | 2537287.1447922 | 7075122.99473268 | 5373074.41423662 | 4995161.517920501 | |||
| P13020 | Gelsolin [OS=Mus musculus] | 122.934 | 35 | 22 | 377 | 9 | 780 | 85.9 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 227753 | ENSMUSG00000026879 | Gsn | mmu:227753; P13020; Q3UPB1; Q8R590 | Regulation of actin cytoskeleton | Neutrophil degranulation; Caspase-mediated cleavage of cytoskeletal proteins | 0.440427841758307 | 0.396306424610341 | 0.186266168629733 | 0.379422692457324 | 0.65414435708462 | 0.994546642862744 | 0.709593139419252 | 0.793590033024783 | 1154075.61374729 | 1486973.5078743 | 778278.604931373 | 1139775.9088509877 | 1.0611315000974E7 | 9755419.92114226 | 9110194.21443976 | 9825643.045518672 | 6039243.17546894 | 5549542.61366164 | 7725308.54354706 | 6438031.44422588 | 3.63344365935893E7 | 2.77403609084757E7 | 2.33574049877416E7 | 2.9144067496602204E7 | 8417203.0170929 | 1.43392014575414E7 | 1.03453705657478E7 | 1.1033925013460701E7 |
| Q61398 | Procollagen C-endopeptidase enhancer 1 [OS=Mus musculus] | 120.4 | 40 | 14 | 323 | 14 | 468 | 50.1 | protein metabolism;other biological processes | enzyme regulator activity;other molecular function | 18542 | ENSMUSG00000029718 | Pcolce | mmu:18542; O35113; Q61398 | mRNA processing | Collagen biosynthesis and modifying enzymes; Crosslinking of collagen fibrils | 1.65082956259427E-17 | 1.8644578313253E-17 | 0.151224536345852 | 0.288320039261486 | 0.133905327763598 | 0.789540446904924 | 0.0895861566882082 | 0.711902858921665 | 55825.2363051742 | 84655.3590880939 | 113029.200120433 | 84503.2651712337 | 3.10244208090572E7 | 2.97623271730106E7 | 2.79757713270171E7 | 2.958750643636163E7 | 2.72578314339105E7 | 2.28908828526637E7 | 2.54654481194513E7 | 2.52047208020085E7 | 1.54882233602667E7 | 1.24902767859117E7 | 9636426.2851997 | 1.2538308810459368E7 | 5125325.32901055 | 9907837.52014591 | 7984547.74798259 | 7672570.19904635 | |
| P26039 | Talin-1 [OS=Mus musculus] | 118.226 | 15 | 30 | 153 | 30 | 2541 | 269.7 | cell adhesion;cell organization and biogenesis;signal transduction | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;other molecular function | 21894 | ENSMUSG00000028465 | Tln1 | A2AIM8; mmu:21894; P26039; Q8VEF0 | Primary focal segmental glomerulosclerosis (FSGS); Integrin-mediated cell adhesion; Focal adhesion | Platelet degranulation ; MAP2K and MAPK activation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; Smooth Muscle Contraction; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 0.958262397335385 | 0.994542145304377 | 0.680632778351053 | 0.738983404380581 | 0.850917681937748 | 0.783910800136359 | 0.87222702623065 | 0.535066779633529 | 137218.697336797 | 64798.4580467583 | 241653.653741064 | 147890.2697082064 | 580168.664793601 | 803244.58151111 | 320387.746187394 | 567933.664164035 | 118081.406885094 | 124079.798936285 | 255551.526824265 | 165904.24421521465 | 2877993.84785898 | 2114900.66089323 | 1881659.61273992 | 2291518.0404973766 | 240671.449108311 | 385063.079961369 | 234819.255172709 | 286851.2614141297 |
| Q8BPB5 | EGF-containing fibulin-like extracellular matrix protein 1 [OS=Mus musculus] | 117.738 | 49 | 15 | 220 | 15 | 493 | 54.9 | protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes | extracellular matrix | signal transduction activity or receptor binding;kinase activity;other molecular function | 216616 | ENSMUSG00000020467 | Efemp1 | mmu:216616; Q6Y3N6; Q8BPB5 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 0.376780684027729 | 0.278244203695445 | 0.983440558239231 | 0.145805028390539 | 0.982581944728745 | 15298.8221438323 | 19141.8575027524 | 55545.7753728227 | 29995.485006469138 | 7090020.68988726 | 8805500.10345141 | 5126350.07183034 | 7007290.288389671 | 4435222.67421531 | 4392813.74676133 | 4496081.41897935 | 4441372.613318663 | 4016966.57007158 | 3984703.05528875 | 2817881.79753384 | 3606517.1409647237 | 682456.349264741 | 1966499.77195883 | 1462163.85427198 | 1370373.3251651835 | ||
| P09411 | Phosphoglycerate kinase 1 [OS=Mus musculus] | 116.462 | 57 | 18 | 287 | 18 | 417 | 44.5 | protein metabolism;other metabolic processes;stress response;other biological processes | non-structural extracellular;other membranes;cytosol;mitochondrion;other cell component | kinase activity;other molecular function | 18655 | ENSMUSG00000062070 | Pgk1 | mmu:18655; P09411; Q3TPE6; Q3UKV8; Q5XJE7 | Glycolysis and gluconeogenesis | Gluconeogenesis; Glycolysis | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.465126095372736 | 0.766862952867809 | 0.820281310709571 | 0.891044455497809 | 78089.4641074341 | 38741.0917691314 | 23421.0514741904 | 46750.53578358531 | 4316274.39280249 | 5023293.68471847 | 1442874.888393 | 3594147.655304653 | 2829873.33459098 | 2934698.045784 | 3868274.47312523 | 3210948.6178334034 | 1.65254946701665E7 | 1.56270051770472E7 | 1.22346365889796E7 | 1.4795712145397767E7 | 2315853.03926933 | 6654180.61411261 | 4530199.20599689 | 4500077.619792943 |
| P27773 | Protein disulfide-isomerase A3 [OS=Mus musculus] | 115.891 | 55 | 23 | 291 | 23 | 505 | 56.6 | cell adhesion;cell organization and biogenesis;stress response;signal transduction;other biological processes | non-structural extracellular;other membranes;ER/Golgi;other cell component | nucleic acid binding activity;other molecular function | 14827 | ENSMUSG00000027248 | Pdia3 | mmu:14827; P27773; Q3TEI9; Q3TIL2; Q3UZK8; Q8C2F4; Q99LF6 | ER-Phagosome pathway; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Calnexin/calreticulin cycle | 0.9135584231482 | 0.736536116100563 | 0.498293621965442 | 0.874168055361729 | 0.850917681937748 | 0.862063111456553 | 0.881496352314601 | 0.939046770372612 | 206281.038958907 | 253939.7116523 | 128510.108086966 | 196243.61956605766 | 6669793.66068216 | 7133803.24141356 | 5637352.69437344 | 6480316.532156386 | 5319375.96186612 | 3844376.07822282 | 6321729.00885173 | 5161827.016313557 | 1.83298906806341E7 | 1.50101054148645E7 | 1.26051366299531E7 | 1.5315044241817234E7 | 6059857.55300524 | 8984695.03809976 | 6670485.36185494 | 7238345.98431998 | |
| P10107 | Annexin A1 [OS=Mus musculus] | 115.566 | 64 | 18 | 270 | 18 | 346 | 38.7 | cell organization and biogenesis;stress response;transport;signal transduction;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component | enzyme regulator activity;other molecular function | 16952 | ENSMUSG00000024659 | Anxa1 | mmu:16952; P10107 | Spinal cord injury; Prostaglandin synthesis and regulation | G alpha (q) signalling events; G alpha (i) signalling events; Formyl peptide receptors bind formyl peptides and many other ligands | 1.65082956259427E-17 | 0.105053536950499 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.954328834404239 | 0.401885831342676 | 0.529099828181544 | 0.924766494197286 | 13280.9290610842 | 9160.53166722029 | 4508.77124840677 | 8983.410658903753 | 5251880.61554565 | 6740833.31198439 | 6058745.6526555 | 6017153.19339518 | 1560362.01883491 | 1521121.84391776 | 1946127.08618424 | 1675870.316312303 | 1.11990207127477E7 | 1.0990927807692E7 | 1.0321301103113E7 | 1.08370832078509E7 | 3223846.7434476 | 4805492.80063037 | 4605609.45936174 | 4211649.667813237 |
| Cont_Q2KJF1 | Alpha-1B-glycoprotein OS=Bos taurus OX=9913 GN=A1BG PE=1 SV=1 | 115.502 | 48 | 14 | 224 | 14 | 503 | 53.5 | signal transduction | non-structural extracellular;plasma membrane;other membranes | 518955 | A1BG | bta:518955; Q2KJF1 | Platelet degranulation ; Neutrophil degranulation | 0.635218461842139 | 0.655487072215252 | 0.641514600397631 | 0.360991986803736 | 0.932231143665149 | 0.696358249006924 | 0.601376052147163 | 0.891044455497809 | 1.12339445909494E7 | 1.09217008752481E7 | 5999938.28834399 | 9385194.584847162 | 7597724.26810103 | 8696294.29830821 | 1.02832125493257E7 | 8859077.038578315 | 1.08372253099689E7 | 9914324.88654618 | 8710997.51604168 | 9820849.23751892 | 1.11963323092602E7 | 9450705.94975847 | 1.03053408353504E7 | 1.0317459698123023E7 | 5535891.07899516 | 9467766.08082133 | 5283853.74244175 | 6762503.63408608 | |||
| Cont_Q3MHN5 | Vitamin D-binding protein OS=Bos taurus OX=9913 GN=GC PE=2 SV=1 | 113.599 | 55 | 20 | 319 | 20 | 474 | 53.3 | other metabolic processes;transport | non-structural extracellular;other cell component | transporter activity;cytoskeletal activity;other molecular function | 530076 | GC | bta:530076; Q3MHN5 | 0.549057967251154 | 0.804331105646976 | 0.579435037816218 | 0.479472599858427 | 0.946173787415917 | 0.139718417146003 | 0.570795727084329 | 0.421365656927814 | 1.55879441314789E7 | 1.53074066841615E7 | 7458694.29508707 | 1.2784681703575822E7 | 1.04365108192777E7 | 1.20620475306269E7 | 8309099.82300618 | 1.026921939097026E7 | 1.67215053413279E7 | 1.54231806136738E7 | 1.57780518794517E7 | 1.5974245944817802E7 | 1.6556516146824E7 | 1.52311500265876E7 | 1.20681229464E7 | 1.4618596373270534E7 | 9478628.98672491 | 1.47438110125204E7 | 8133055.93664235 | 1.0785165311962552E7 | |||
| P17742 | Peptidyl-prolyl cis-trans isomerase A [OS=Mus musculus] | 113.527 | 60 | 9 | 369 | 9 | 164 | 18 | cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes | non-structural extracellular;cytosol;nucleus;other cell component | signal transduction activity or receptor binding;other molecular function | 268373 | ENSMUSG00000071866 | Ppia | mmu:268373; P17742; Q9CWJ5; Q9R137 | Neutrophil degranulation; Basigin interactions | 0.100219677394751 | 0.099382125133403 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.946239447314336 | 0.696358249006924 | 0.937453377971347 | 0.331144967260478 | 1.16891341386391E7 | 754837.409863468 | 4157779.88062054 | 5533917.143041036 | 2.9189343463191E7 | 2.94929696895869E7 | 4.96473559496876E7 | 3.610988970082183E7 | 1.04342545713823E7 | 8178713.43858634 | 1.18234267071803E7 | 1.0145464905716315E7 | 4.91534751033825E7 | 4.2865019365108E7 | 4.61937263356195E7 | 4.607074026803666E7 | 7275434.18699702 | 1.51319991253865E7 | 9682919.1999608 | 1.0696784170781441E7 | |
| Q69ZN7 | Myoferlin [OS=Mus musculus] | 112.647 | 22 | 36 | 227 | 36 | 2048 | 233.2 | cell organization and biogenesis;other metabolic processes;stress response;other biological processes | plasma membrane;other membranes;nucleus | other molecular function | 226101 | ENSMUSG00000048612 | Myof | mmu:226101; Q69ZN7; Q7TMG0; Q80V33; Q8BU64; Q8BU70; Q8BUC1; Q8BVY6; Q8C0D1; Q8R3B4 | 0.73657372909066 | 0.964709887217926 | 0.888974672311279 | 0.930955411749965 | 0.816275429153737 | 0.877818946381645 | 0.609903091678244 | 0.975029032316037 | 86000.3771233404 | 87234.2597428081 | 50456.7230101595 | 74563.786625436 | 780930.944201502 | 985609.680593147 | 968573.73043394 | 911704.7850761963 | 296294.389327177 | 289800.794039455 | 380995.072506467 | 322363.41862436634 | 3324626.35891918 | 3238695.05806667 | 2634093.62813707 | 3065805.015040973 | 993761.586050851 | 1295229.11918404 | 1025817.2029614 | 1104935.9693987637 | ||
| P26041 | Moesin [OS=Mus musculus] | 112.068 | 47 | 28 | 353 | 19 | 577 | 67.7 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function | 17698 | ENSMUSG00000031207 | Msn | B1AX70; mmu:17698; P26041; Q3UL28; Q8BSN4 | Regulation of actin cytoskeleton | Recycling pathway of L1 | 1.65082956259427E-17 | 0.0604972675946614 | 1.50457038391225E-17 | 0.157138696252226 | 0.910750689050232 | 0.682171843898269 | 0.97925982662951 | 0.954396180425051 | 3509434.20481405 | 4360753.56845675 | 2823311.97478394 | 3564499.916018247 | 1.57847182977139E7 | 1.58696599538661E7 | 1.95033967654703E7 | 1.7052591672350097E7 | 8383545.44173348 | 7552431.53754312 | 1.1473115873696E7 | 9136364.2843242 | 2.43209045148915E7 | 1.7265255344344E7 | 1.55060800034236E7 | 1.9030746620886367E7 | 1.24969658442338E7 | 1.31486313258361E7 | 7954804.76477835 | 1.120013397828275E7 |
| P05064 | Fructose-bisphosphate aldolase A [OS=Mus musculus] | 112.015 | 66 | 18 | 261 | 18 | 364 | 39.3 | cell organization and biogenesis;other metabolic processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | other molecular function | 11674 | ENSMUSG00000030695 | Aldoa | mmu:11674; P05064 | Glycolysis and gluconeogenesis | Platelet degranulation ; Neutrophil degranulation; Gluconeogenesis; Glycolysis | 0.101571037453114 | 0.00616383846364181 | 1.50457038391225E-17 | 0.0771819601934254 | 0.907383519445145 | 0.828577692034317 | 0.988377544628277 | 0.953305976192702 | 36553.7681309936 | 18014.3910425567 | 11156.0078725057 | 21908.055682018665 | 5538849.24179232 | 5285372.3367409 | 3856062.26656154 | 4893427.94836492 | 4263443.39983126 | 3386915.16711964 | 5306808.16889341 | 4319055.57861477 | 1.24814165546298E7 | 1.09515793948855E7 | 8528808.13475854 | 1.0653934694757948E7 | 4075248.71161469 | 5289067.55868911 | 4192052.54158905 | 4518789.603964283 |
| B2RQC6 | Multifunctional protein CAD [OS=Mus musculus] | 111.853 | 18 | 32 | 111 | 32 | 2225 | 243.1 | other metabolic processes;stress response;transport;developmental processes;other biological processes | cytosol;nucleus;other cell component | kinase activity;other molecular function | 69719 | ENSMUSG00000013629 | Cad | B2RQC6; B7ZN27; mmu:69719 | Mechanisms associated with pluripotency | Pyrimidine biosynthesis | 0.69394578118832 | 0.6681512188534 | 0.666244110962191 | 0.963127218853016 | 0.340675523776301 | 0.968897093792999 | 0.798180783050573 | 0.621633895543644 | 55886.6384121637 | 12993.9975368397 | 34438.2113153553 | 34439.61575478624 | 1026045.60319635 | 1025412.85494839 | 821784.178770446 | 957747.5456383955 | 383358.762218724 | 322831.339780162 | 640190.890369534 | 448793.6641228067 | 516093.312619156 | 478923.162373783 | 363366.537093714 | 452794.3373622177 | 110686.677299138 | 180829.981634378 | 127462.003140709 | 139659.55402474166 |
| Q8BND5 | Sulfhydryl oxidase 1 [OS=Mus musculus] | 111.186 | 35 | 22 | 242 | 22 | 748 | 82.7 | cell organization and biogenesis;other biological processes | non-structural extracellular;other membranes;ER/Golgi | other molecular function | 104009 | ENSMUSG00000033684 | Qsox1 | mmu:104009; Q3TDY9; Q3TE19; Q3TR29; Q3UEL4; Q8BND5; Q8K041; Q9DBL6 | Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Neutrophil degranulation | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 0.162753188077458 | 0.203109767081086 | 0.696358249006924 | 0.331332346840573 | 0.877612009404373 | 40119.4404166161 | 10016.9610840251 | 25068.200750320597 | 9134645.28263017 | 1.19624109837519E7 | 1.04856878607794E7 | 1.052758137572049E7 | 3750508.26959308 | 3765475.87858746 | 4032369.19900008 | 3849451.1157268733 | 5503994.64256118 | 5774708.06447186 | 3841814.38132964 | 5040172.36278756 | 1169677.75963505 | 2786812.01379908 | 1498357.95430882 | 1818282.5759143168 |
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| Accession | Description | Sum PEP Score | Coverage [%] | # Peptides | # PSMs | # Unique Peptides | # AAs | MW [kDa] | Biological Process | Cellular Component | Molecular Function | Entrez Gene ID | Ensembl Gene ID | Gene Symbol | Gene ID | WikiPathways | Reactome Pathways | Abundance Ratio Adj. P-Value: (LQ_16h) / (FM) | Abundance Ratio Adj. P-Value: (LQ_6h) / (FM) | Abundance Ratio Adj. P-Value: (SQ_16h) / (FM) | Abundance Ratio Adj. P-Value: (SQ_6h) / (FM) | Abundance Ratio Adj. P-Value: (LQ_16h) / (LQ_6h) | Abundance Ratio Adj. P-Value: (SQ_6h) / (LQ_6h) | Abundance Ratio Adj. P-Value: (SQ_16h) / (SQ_6h) | FM_AVERAGE | LQ6h_AVERAGE | LQ16h_AVERAGE | SQ6h_AVERAGE | SQ16h_AVERAGE | |
| P11276 | Fibronectin [OS=Mus musculus] | 867.353 | 58 | 95 | 2246 | 59 | 2477 | 272.4 | cell adhesion;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi | signal transduction activity or receptor binding;enzyme regulator activity;other molecular function | 14268 | ENSMUSG00000026193 | Fn1 | G5E8B8; mmu:14268; P11276; Q61567; Q61568; Q61569; Q64233; Q80UI4 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Inflammatory response pathway; Regulation of actin cytoskeleton; Comprehensive IL-17A signaling; Focal adhesion | ECM proteoglycans; Platelet degranulation ; Cell surface interactions at the vascular wall; Syndecan interactions; MAP2K and MAPK activation; Integrin cell surface interactions; Molecules associated with elastic fibres; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Fibronectin matrix formation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; Degradation of the extracellular matrix; Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells; MET activates PTK2 signaling; GPER1 signaling | 0.0844744457809114 | 0.00584906503121538 | 1.50457038391225E-17 | 0.156115961659409 | 0.564710097967506 | 0.435823028559966 | 0.896613838854506 | 2.7641453377804603E7 | 2.022341523870097E8 | 2.12696235413058E8 | 1.2629719382404166E8 | 2.74958241507436E8 | |
| P11087 | Collagen alpha-1(I) chain [OS=Mus musculus] | 797.017 | 79 | 75 | 1933 | 35 | 1453 | 137.9 | cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12842 | ENSMUSG00000001506 | Col1a1 | mmu:12842; P11087; Q53WT0; Q60635; Q61367; Q61427; Q63919; Q6PCL3; Q810J9 | Osteoblast signaling; Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Comprehensive IL-17A signaling; Focal adhesion | Cell surface interactions at the vascular wall; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ECM proteoglycans; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; GPVI-mediated activation cascade; GP1b-IX-V activation signalling; Platelet Adhesion to exposed collagen; Platelet Aggregation (Plug Formation); MET activates PTK2 signaling | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.381922652011049 | 0.0629214061377862 | 0.655833157547641 | 772438.0834537543 | 2.0798706453114033E8 | 5.92854376184685E8 | 5.973622733379293E7 | 8.428319253806247E7 | |
| Q01149 | Collagen alpha-2(I) chain [OS=Mus musculus] | 773.662 | 80 | 66 | 1731 | 51 | 1372 | 129.5 | cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12843 | ENSMUSG00000029661 | Col1a2 | mmu:12843; Q01149; Q8CGA5 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Focal adhesion | Crosslinking of collagen fibrils; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; ECM proteoglycans; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; GPVI-mediated activation cascade; GP1b-IX-V activation signalling; Platelet Adhesion to exposed collagen; Platelet Aggregation (Plug Formation); MET activates PTK2 signaling | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.862063111456553 | 0.0347692006632991 | 0.926292871155025 | 182180.3275564673 | 1.7308392932505235E8 | 3.475967473053053E8 | 4.271481968913147E7 | 9.036410240893161E7 | |
| P08121 | Collagen alpha-1(III) chain [OS=Mus musculus] | 695.631 | 63 | 61 | 1789 | 51 | 1464 | 138.9 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | extracellular matrix;other cell component | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 12825 | ENSMUSG00000026043 | Col3a1 | mmu:12825; P08121; Q61429; Q9CRN7 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Focal adhesion | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ECM proteoglycans; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; MET activates PTK2 signaling | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.0413994480640273 | 0.394949139624895 | 0.976852696203657 | 454748.1180174556 | 6.282890624937943E7 | 2.8394661715058166E8 | 3.0365458724261332E7 | 6.6157215803336866E7 | |
| Q9QXS1 | Plectin [OS=Mus musculus] | 659.702 | 46 | 182 | 1705 | 180 | 4691 | 533.9 | cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component | cytoskeletal activity;other molecular function | 18810 | ENSMUSG00000022565 | Plec | E9QN87; mmu:18810; Q6S384; Q6S389; Q6S394; Q9CS65; Q9QUT2; Q9QXQ8; Q9QXQ9; Q9QXR0; Q9QXR1; Q9QXR2; Q9QXR3; Q9QXR4; Q9QXR5; Q9QXR6; Q9QXR7; Q9QXR8; Q9QXR9; Q9QXS0; Q9QXS1; Q9QXS2; Q9QXS3 | Alpha 6 beta 4 integrin signaling pathway; EGFR1 signaling pathway | Type I hemidesmosome assembly; Caspase-mediated cleavage of cytoskeletal proteins | 0.481729871164266 | 0.714932595871944 | 0.336550483871782 | 0.572524806937582 | 0.532399788858771 | 0.702330308974487 | 0.520376293994664 | 309922.514176982 | 4599273.114185064 | 1.6676006673579365E7 | 1.01501282886872E7 | 4.28490141732006E7 | |
| P08122 | Collagen alpha-2(IV) chain [OS=Mus musculus] | 526.992 | 64 | 69 | 1077 | 69 | 1707 | 167.2 | RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix | extracellular structural activity | 12827 | ENSMUSG00000031503 | Col4a2 | mmu:12827; P08122; Q3B7C2; Q3TPV9; Q61375; Q66JS5; Q6RCT6; Q6RCT7; Q6U9X1; Q8BPI9; Q8BPK3; Q91VI3 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Focal adhesion | Laminin interactions; Signaling by PDGF; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions | 0.352816378116182 | 0.64759425713406 | 0.293387877727491 | 0.79866917976589 | 0.169673447599406 | 0.959159975702413 | 0.483015668880262 | 1393534.8123072747 | 1.3981747232493034E7 | 5.0194805286054574E7 | 1.701609057115766E7 | 5.972856146483746E7 | |
| Q3U962 | Collagen alpha-2(V) chain [OS=Mus musculus] | 518.514 | 64 | 57 | 817 | 55 | 1497 | 144.9 | cell organization and biogenesis;developmental processes;other biological processes | extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12832 | ENSMUSG00000026042 | Col5a2 | mmu:12832; Q3TVR2; Q3U962; Q3UHK7; Q3UTT4; Q3V1J6; Q61431; Q7TMS0; Q80VS8 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions | 0.861384746267066 | 0.961254912149485 | 0.730324052254867 | 0.632833892117728 | 0.273444295895674 | 0.453486790198347 | 0.973358018692255 | 2.4419841082594533E7 | 1.5753424919239333E7 | 4.592471970087584E7 | 1.0471363011153279E7 | 2.1079551940947264E7 | |
| Q05793 | Basement membrane-specific heparan sulfate proteoglycan core protein [OS=Mus musculus] | 507.28 | 33 | 84 | 998 | 84 | 3707 | 398 | cell organization and biogenesis;transport;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;ER/Golgi | other molecular function | 15530 | Hspg2 | mmu:15530; Q05793 | 0.332090710292395 | 0.382764581022518 | 0.771134174410141 | 0.553652046981626 | 0.938381933295379 | 0.285967432697218 | 0.908661395894721 | 171009.25706548532 | 2.1355561683383033E7 | 4.109385814368304E7 | 8244737.341084313 | 1.8998181152407136E7 | ||||
| Q61554 | Fibrillin-1 [OS=Mus musculus] | 499.202 | 38 | 86 | 1117 | 86 | 2873 | 312.1 | cell adhesion;other metabolic processes;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 14118 | ENSMUSG00000027204 | Fbn1 | A2AQ53; mmu:14118; Q60826; Q61554 | Comprehensive IL-17A signaling | Integrin cell surface interactions; Degradation of the extracellular matrix; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; TGF-beta receptor signaling activates SMADs; Molecules associated with elastic fibres | 0.0596853092747711 | 0.0840496117897429 | 0.378389090130589 | 0.84258396038376 | 0.862063111456553 | 0.0455630470425967 | 0.77820123247099 | 81731.837224874 | 2.17735814942991E7 | 5.216417896597137E7 | 5145074.9913376765 | 2.082557122129057E7 | |
| Q8BTM8 | Filamin-A [OS=Mus musculus] | 493.069 | 49 | 91 | 915 | 83 | 2647 | 281 | cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;other molecular function | 192176 | ENSMUSG00000031328 | Flna | B7FAV0; O54934; Q7TQI1; Q8BLK1; Q8BTM8; Q8BTN7; Q8VHX5; Q8VHX8; Q99KQ2 | Mapk signaling pathway; Focal adhesion | Platelet degranulation ; Cell-extracellular matrix interactions; RHO GTPases activate PAKs; GP1b-IX-V activation signalling | 0.0844935092512095 | 0.493514006575528 | 0.170420349138264 | 0.67528135146603 | 0.864215513767001 | 0.904360680536565 | 0.8468455705593 | 218480.8558628913 | 4952287.405198824 | 1.1395384793048913E7 | 4296604.098486893 | 1.4686023116833666E7 | |
| P02463 | Collagen alpha-1(IV) chain [OS=Mus musculus] | 487.707 | 70 | 68 | 828 | 68 | 1669 | 160.6 | cell organization and biogenesis;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix | extracellular structural activity;other molecular function | 12826 | ENSMUSG00000031502 | Col4a1 | mmu:12826; P02463; Q3UHJ4; Q3UJE7; Q3UQV2; Q53X35; Q6GQS7; Q6PHB5; Q99LQ8 | Spinal cord injury; Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Laminin interactions; Signaling by PDGF; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions | 0.604225174343649 | 0.68008321917751 | 0.284160251285083 | 0.936818656936794 | 0.167300285011781 | 0.777395712279767 | 0.224623005929948 | 262271.417553364 | 4620515.057112186 | 2.1463797748519864E7 | 8911949.32392111 | 3.3156314746725336E7 | |
| Q60847 | Collagen alpha-1(XII) chain [OS=Mus musculus] | 480.266 | 40 | 95 | 991 | 95 | 3120 | 340 | cell adhesion;developmental processes | other cell component | 12816 | ENSMUSG00000032332 | Col12a1 | mmu:12816; P70322; Q60847 | Assembly of collagen fibrils and other multimeric structures; Collagen chain trimerization; Collagen degradation | 0.0975092237649803 | 1.8644578313253E-17 | 0.344512840834051 | 0.162753188077458 | 0.101350980560035 | 0.0103905836841461 | 0.266844028199729 | 80180.17821443231 | 5.1736330625803865E7 | 2.9952489655588504E7 | 1.0537780206453351E7 | 1.4629541968462234E7 | |||
| Q8VDD5 | Myosin-9 [OS=Mus musculus] | 418.364 | 45 | 73 | 827 | 60 | 1960 | 226.2 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;stress response;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;other molecular function | 17886 | ENSMUSG00000022443 | Myh9 | mmu:17886; Q3UHT9; Q3UHU4; Q6KAN6; Q811I2; Q8VDD5 | Primary focal segmental glomerulosclerosis (FSGS) | RHO GTPases activate PAKs; Regulation of actin dynamics for phagocytic cup formation | 0.156498497144098 | 0.0382609387499984 | 0.118876667035285 | 0.15125389278925 | 0.916542675526027 | 0.91728043005175 | 0.990873516209569 | 100319.6147091511 | 5176534.940650649 | 8067345.413832072 | 7844465.70271172 | 1.9759662960152034E7 | |
| Cont_P02453 | Collagen alpha-1(I) chain OS=Bos taurus OX=9913 GN=COL1A1 PE=1 SV=3 | 414.689 | 43 | 43 | 1208 | 4 | 1463 | 138.9 | cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | 282187 | ENSBTAG00000013103 | COL1A1 | bta:282187; P02453; Q3MHM2 | Inflammatory response pathway; Osteoblast signaling; Focal adhesion | Fibronectin matrix formation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Collagen degradation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; Collagen chain trimerization; GPVI-mediated activation cascade; Platelet Aggregation (Plug Formation); Platelet Adhesion to exposed collagen; GP1b-IX-V activation signalling | 0.800889767710788 | 0.579410556046386 | 0.58548007712969 | 0.839216523231753 | 0.848119069115724 | 0.108042253370914 | 0.0107964100780951 | 228542.54091026666 | 3262486.7198886867 | 3910059.36528234 | 1102058.9569362423 | 924822.5329095138 | |
| Cont_P02769 | Albumin OS=Bos taurus OX=9913 GN=ALB PE=1 SV=4 | 390.555 | 81 | 57 | 7095 | 54 | 607 | 69.2 | stress response;other biological processes | non-structural extracellular;other cell component | nucleic acid binding activity;other molecular function | 280717 | ALB | A5PJX3; bta:280717; O02787; P02769; P04277; Q3SZR2 | 0.520832629933248 | 0.650544967914241 | 0.598172767155558 | 0.497906326712893 | 0.413798631523592 | 0.846117085258013 | 0.468531677746422 | 2.7142766432154403E9 | 2.9099571807541137E9 | 2.4034772237737E9 | 2.38097622607819E9 | 2.6841204207378564E9 | ||||
| P01027 | Complement C3 [OS=Mus musculus] | 388.541 | 53 | 70 | 1148 | 62 | 1663 | 186.4 | cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular;other cell component | signal transduction activity or receptor binding;enzyme regulator activity | 12266 | ENSMUSG00000024164 | C3 | mmu:12266; P01027; Q61370; Q80XP1 | Complement activation, classical pathway; Tyrobp causal network in microglia; Comprehensive IL-17A signaling | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade; Neutrophil degranulation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; G alpha (i) signalling events; Peptide ligand-binding receptors; Alternative complement activation; Activation of C3 and C5 | 0.712660037675161 | 0.729783028721347 | 0.506101547380209 | 0.762068821001752 | 0.512232143465318 | 0.413470300505934 | 0.991722673088443 | 3269916.660849947 | 1.6657146132333001E7 | 4.4549110086954266E7 | 3.6733221642207734E7 | 8.026680998659676E7 | |
| Cont_Q7SIH1 | Alpha-2-macroglobulin OS=Bos taurus OX=9913 GN=A2M PE=1 SV=2 | 370.864 | 53 | 56 | 1089 | 56 | 1510 | 167.5 | non-structural extracellular | enzyme regulator activity;other molecular function | 513856 | ENSBTAG00000018137 | A2M | A8E647; bta:513856; Q7SIH1 | IL-6 signaling pathway | 0.688450665125024 | 0.839052280267302 | 0.731111241255251 | 0.509007335932165 | 0.540124873725708 | 0.671798309985569 | 0.809503222445875 | 5.423624331449187E7 | 7.564994624258716E7 | 7.018676700369896E7 | 5.23492843648457E7 | 8.250822323914327E7 | |||
| Cont_Q29443 | Serotransferrin OS=Bos taurus OX=9913 GN=TF PE=2 SV=1 | 343.183 | 74 | 48 | 1709 | 46 | 704 | 77.7 | stress response;transport;other biological processes | non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle | other molecular function | 280705 | TF | bta:280705; Q0IIK2; Q29443 | 0.615274986253429 | 0.964709887217926 | 0.600414647182016 | 0.571407162236119 | 0.105569810421019 | 0.506704636011438 | 0.313748671859839 | 1.48932090998098E8 | 2.32106703986673E8 | 1.5606409762411097E8 | 1.3567523181654152E8 | 1.6257112433260167E8 | ||||
| Cont_P07589 | Fibronectin OS=Bos taurus OX=9913 GN=FN1 PE=1 SV=4 | 337.517 | 26 | 47 | 923 | 11 | 2478 | 272 | cell adhesion;cell organization and biogenesis;stress response;developmental processes;other biological processes | non-structural extracellular | signal transduction activity or receptor binding;other molecular function | FN1 | P07589 | 0.714071857030863 | 0.525827426782658 | 0.94971810013306 | 0.802863674292211 | 0.634088329627404 | 0.35834247597224 | 0.281927255363179 | 166255.75410196633 | 835883.8306505851 | 952169.9232567847 | 482619.7682389803 | 602598.7403397557 | |||||
| Q80X90 | Filamin-B [OS=Mus musculus] | 335.882 | 38 | 75 | 608 | 66 | 2602 | 277.7 | cell organization and biogenesis;stress response;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 286940 | ENSMUSG00000025278 | Flnb | E9QNV9; mmu:286940; Q80X90; Q8VHX4; Q8VHX7; Q99KY3 | ISG15 antiviral mechanism | 0.296944306247309 | 0.238365792894698 | 0.254729742039053 | 0.629546282386664 | 0.897564267605108 | 0.872448101434609 | 0.866446545996913 | 154624.23024854946 | 2351112.5534752235 | 6048828.490809467 | 1865154.4144755967 | 7592568.170254476 | ||
| Cont_P35527 | Keratin, type I cytoskeletal 9 OS=Homo sapiens OX=9606 GN=KRT9 PE=1 SV=3 | 310.424 | 69 | 35 | 915 | 34 | 623 | 62 | cell organization and biogenesis;other biological processes | cytosol;cytoskeleton | cytoskeletal activity | 3857 | ENSG00000171403 | KRT9 | hsa:3857; O00109; P35527; Q0IJ47; Q14665 | Formation of the cornified envelope | 0.836660982916281 | 0.73072258897653 | 0.769556732848094 | 0.964570089320365 | 0.936669139837906 | 0.516448827835279 | 0.0110179641295352 | 2.9224080803851068E7 | 3.250630567014273E7 | 4.1318104811136335E7 | 9.369998400542612E7 | 5.1433611479478456E7 | ||
| Cont_P04264 | Keratin, type II cytoskeletal 1 OS=Homo sapiens OX=9606 GN=KRT1 PE=1 SV=6 | 306.58 | 65 | 45 | 1774 | 36 | 644 | 66 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;other molecular function | 3848 | ENSG00000167768 | KRT1 | B2RA01; hsa:3848; P04264; P85925; P86104; Q14720; Q6GSJ0; Q9H298 | Corticotropin-releasing hormone signaling | Formation of the cornified envelope; Neutrophil degranulation; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.65780924735352 | 0.653826967689551 | 0.631165145316661 | 0.89629386854896 | 0.770634810212039 | 0.254077056479593 | 5.78940441291519E-5 | 1.5397854514739665E8 | 1.3414412508194733E8 | 1.6528138436319932E8 | 4.476405570139613E8 | 1.7631437693719265E8 | |
| P06909 | Complement factor H [OS=Mus musculus] | 292.01 | 49 | 41 | 540 | 41 | 1234 | 139 | cell adhesion;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes | non-structural extracellular;plasma membrane;other membranes;mitochondrion;other cell component | other molecular function | 12628 | ENSMUSG00000026365 | Cfh | mmu:12628; P06909; Q6NZK3 | Regulation of Complement cascade | 0.205200089226065 | 0.0359547312524068 | 1.50457038391225E-17 | 0.329485122608543 | 0.532399788858771 | 0.750662231008662 | 0.443116920082088 | 59542.32714759521 | 1.0566840244224759E7 | 1.036081717107911E7 | 8439848.284125684 | 2.9357524779450033E7 | ||
| P16546 | Spectrin alpha chain, non-erythrocytic 1 [OS=Mus musculus] | 291.854 | 35 | 74 | 473 | 74 | 2472 | 284.4 | cell organization and biogenesis | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 20740 | ENSMUSG00000057738 | Sptan1 | A3KGU6; A3KGU8; P16546; Q8K380; Q9CT05 | FAS pathway and stress induction of HSP regulation | Neutrophil degranulation; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Interaction between L1 and Ankyrins; COPI-mediated anterograde transport; RHOU GTPase cycle; RHOV GTPase cycle; Caspase-mediated cleavage of cytoskeletal proteins | 0.958962194559628 | 0.786160319109602 | 0.611910908670005 | 0.890289034593217 | 0.771887919257916 | 0.870511801558508 | 0.852906094467594 | 684626.7741473566 | 1427277.73205798 | 3976922.979229001 | 2263434.85725903 | 8138355.29233573 | |
| Cont_P13645 | Keratin, type I cytoskeletal 10 OS=Homo sapiens OX=9606 GN=KRT10 PE=1 SV=6 | 286.713 | 62 | 30 | 1322 | 20 | 584 | 58.8 | cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes | plasma membrane;cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;other molecular function | 3858 | ENSG00000186395 | KRT10 | hsa:3858; P13645; Q14664; Q8N175 | Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.600890052902075 | 0.490821286240141 | 0.561934876627864 | 0.941696908693733 | 0.880940844456856 | 0.246231694954624 | 2.55433624902191E-5 | 1.1091978559495355E8 | 9.409796786421584E7 | 1.13950700113199E8 | 3.19749190691826E8 | 1.0914077913761683E8 | ||
| Cont_P35908 | Keratin, type II cytoskeletal 2 epidermal OS=Homo sapiens OX=9606 GN=KRT2 PE=1 SV=2 | 284.975 | 78 | 42 | 1022 | 32 | 639 | 65.4 | cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes | plasma membrane;cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;cytoskeletal activity | 3849 | ENSG00000172867 | KRT2 | hsa:3849; P35908; Q4VAQ2 | Formation of the cornified envelope | 0.499413631103761 | 0.411258958244596 | 0.544106843431104 | 0.933570718645937 | 0.862063111456553 | 0.309041843038519 | 2.9837536993241E-4 | 4.776750778997586E7 | 2.9357809740500167E7 | 3.415287514761583E7 | 7.640800383787991E7 | 3.617272663897294E7 | ||
| Q62059 | Versican core protein [OS=Mus musculus] | 279.715 | 17 | 44 | 1073 | 44 | 3357 | 366.6 | cell adhesion;developmental processes | non-structural extracellular;extracellular matrix;other cell component | other molecular function | Vcan | Q62058; Q62059; Q9CUU0 | ECM proteoglycans; Glycosaminoglycan-protein linkage region biosynthesis; CS/DS degradation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; CS-GAG biosynthesis; DS-GAG biosynthesis | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.613304974369123 | 0.478009151463064 | 0.783304059803245 | 104188.56292801573 | 9.037034497028168E7 | 9.467651077277745E7 | 5.89459061512507E7 | 9.510262638582683E7 | ||||
| P10493 | Nidogen-1 [OS=Mus musculus] | 275.191 | 43 | 42 | 852 | 42 | 1245 | 136.5 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | other molecular function | 18073 | ENSMUSG00000005397 | Nid1 | mmu:18073; P10493; Q3TKX9; Q8BQI3; Q8C3U8; Q8C9P6 | Laminin interactions; Degradation of the extracellular matrix | 1.65082956259427E-17 | 1.8644578313253E-17 | 0.251140212279038 | 0.461941385639594 | 0.604382524464811 | 1.0740690550749E-5 | 0.781368126060588 | 322455.2944414853 | 1.2120394496125467E8 | 1.2671518083095133E8 | 9146738.193898173 | 3.1971627034095198E7 | ||
| O88207 | Collagen alpha-1(V) chain [OS=Mus musculus] | 275.025 | 46 | 52 | 413 | 44 | 1838 | 183.6 | cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes | extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12831 | ENSMUSG00000026837 | Col5a1 | A3KGE3; mmu:12831; O88207; Q3UG94; Q6F6B0 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | ECM proteoglycans; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; MET activates PTK2 signaling | 1.65082956259427E-17 | 1.8644578313253E-17 | 0.268653947705267 | 0.311207075116757 | 0.848119069115724 | 0.302671730722046 | 0.809503222445875 | 80388.83753211687 | 3577832.3612721 | 8562033.320911517 | 1386447.3981625708 | 3098568.0509616495 | |
| P37889 | Fibulin-2 [OS=Mus musculus] | 269.894 | 43 | 37 | 791 | 37 | 1221 | 131.7 | other biological processes | non-structural extracellular | other molecular function | 14115 | ENSMUSG00000064080 | Fbln2 | G5E8B3; mmu:14115; P37889; Q9WUI2 | Molecules associated with elastic fibres | 1.65082956259427E-17 | 0.0640195441309023 | 0.201227492083465 | 0.255240026777032 | 0.803447472095846 | 0.290132264062119 | 0.809503222445875 | 362692.0010392267 | 6.556805587417743E7 | 8.021475911820169E7 | 3.00676966042863E7 | 4.93487108032657E7 | ||
| Q8VHX6 | Filamin-C [OS=Mus musculus] | 249.498 | 31 | 65 | 425 | 56 | 2726 | 290.9 | cell organization and biogenesis;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity | 68794 | ENSMUSG00000068699 | Flnc | B2RY80; B9EKT2; mmu:68794; Q6PAI6; Q8VHX6; Q9JJ38 | Cell-extracellular matrix interactions | 0.562594032195739 | 0.719627996749639 | 0.962331548063155 | 0.57290809187594 | 0.96786708205164 | 0.933437821008547 | 0.80954066750699 | 406087.97266412666 | 1016453.1391661359 | 2089599.8263247435 | 1136666.5742976035 | 4459384.47065665 | ||
| Q04857 | Collagen alpha-1(VI) chain [OS=Mus musculus] | 248.981 | 44 | 33 | 588 | 33 | 1025 | 108.4 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component | other molecular function | 12833 | ENSMUSG00000001119 | Col6a1 | mmu:12833; Q04857 | ECM proteoglycans; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Signaling by PDGF; NCAM1 interactions | 0.2534363617947 | 0.392208211277376 | 0.962331548063155 | 0.971216996811237 | 0.97504218639442 | 0.115965329440656 | 0.380888676065133 | 76865.2077476112 | 5.0068940213435836E7 | 6.914260176814564E7 | 1.4473176745930666E7 | 1.9886194591010433E7 | ||
| Cont_Q2UVX4 | Complement C3 OS=Bos taurus OX=9913 GN=C3 PE=1 SV=2 | 247.154 | 39 | 55 | 851 | 47 | 1661 | 187.1 | cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular;other cell component | signal transduction activity or receptor binding;enzyme regulator activity | 280677 | ENSBTAG00000017280 | C3 | bta:280677; Q2KIZ4; Q2UVX4 | Complement and coagulation cascades; Complement activation, classical pathway | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Neutrophil degranulation; Peptide ligand-binding receptors; G alpha (i) signalling events; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade; Alternative complement activation; Activation of C3 and C5 | 0.615680953989958 | 0.798729234704005 | 0.573945385766997 | 0.506364847510615 | 0.291700662163587 | 0.591028379533681 | 0.448532796991499 | 1.4686759191254234E7 | 1.84550126489547E7 | 1.5291804049274266E7 | 1.196234797265725E7 | 1.6127794015790733E7 | |
| Q62261 | Spectrin beta chain, non-erythrocytic 1 [OS=Mus musculus] | 244.684 | 30 | 61 | 398 | 61 | 2363 | 274.1 | cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 20742 | ENSMUSG00000020315 | Sptbn1 | A2AFU1; mmu:20742; Q3TEM7; Q5SQL8; Q5SQL9; Q62261; Q9QWJ7 | COPI-mediated anterograde transport; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; RHOU GTPase cycle; Interaction between L1 and Ankyrins; RHOV GTPase cycle | 0.69394578118832 | 0.776437620310661 | 0.693719649766064 | 0.831411077141515 | 0.86315143463057 | 0.664971370235365 | 0.953305976192702 | 492454.03878621367 | 920886.7046363313 | 2921004.358024217 | 2299979.2063157237 | 6417771.720584608 | ||
| Q640N1 | Adipocyte enhancer-binding protein 1 [OS=Mus musculus] | 239.707 | 38 | 34 | 648 | 34 | 1128 | 128.3 | protein metabolism;other biological processes | nucleus;other cell component | nucleic acid binding activity;other molecular function | 11568 | ENSMUSG00000020473 | Aebp1 | mmu:11568; O88442; Q3TVV5; Q3TWA7; Q3TX56; Q3TXB2; Q5NCI9; Q61281; Q640N1 | 0.269326617826563 | 0.0457359864845759 | 0.605387748357992 | 0.631359014803774 | 0.760992448481534 | 0.145805028390539 | 0.963436677882021 | 4843934.666021533 | 3.9556778473622136E7 | 4.1143769603117764E7 | 1.8648394999714002E7 | 3.1901344171106894E7 | |||
| P57780 | Alpha-actinin-4 [OS=Mus musculus] | 239.42 | 58 | 45 | 483 | 30 | 912 | 104.9 | cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes | cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 60595 | ENSMUSG00000054808 | Actn4 | mmu:60595; P57780 | Primary focal segmental glomerulosclerosis (FSGS) | Platelet degranulation | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 0.19149089837131 | 0.795351011232032 | 0.968364585136618 | 0.938282411159324 | 20900.169415734228 | 4580996.01302682 | 9830280.285985528 | 4440337.50144963 | 1.1658414413951913E7 | |
| Q7TPR4 | Alpha-actinin-1 [OS=Mus musculus] | 235.529 | 54 | 42 | 511 | 27 | 892 | 103 | cell adhesion;cell organization and biogenesis;other biological processes | plasma membrane;other membranes;cytoskeleton;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function | 109711 | ENSMUSG00000015143 | Actn1 | mmu:109711; Q7TPR4 | Regulation of actin cytoskeleton; Integrin-mediated cell adhesion; Focal adhesion | Platelet degranulation ; RHOF GTPase cycle; RHOBTB2 GTPase cycle; RHOD GTPase cycle; Regulation of cytoskeletal remodeling and cell spreading by IPP complex components | 0.995554138371554 | 0.178726136005694 | 0.819280225722906 | 0.941696908693733 | 0.744084716394381 | 0.837231569641376 | 0.879972045955715 | 486802.1989182571 | 2525588.7379033365 | 6210475.170240924 | 3717490.65968503 | 9946958.94260729 | |
| P02468 | Laminin subunit gamma-1 [OS=Mus musculus] | 230.882 | 35 | 43 | 454 | 43 | 1607 | 177.2 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | Lamc1 | P02468 | 0.118212047511996 | 0.116315527815218 | 0.459134305737471 | 0.675951294045723 | 0.877818946381645 | 0.368062651583427 | 0.922276466908065 | 18104.5719498812 | 7327169.184632126 | 1.61740059690847E7 | 3246292.9185144133 | 7951596.802164167 | |||||
| Q91ZX7 | Prolow-density lipoprotein receptor-related protein 1 [OS=Mus musculus] | 230.497 | 15 | 57 | 519 | 56 | 4545 | 504.4 | other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;other molecular function | 16971 | Lrp1 | mmu:16971; Q61291; Q91ZX7; Q920Y4 | Statin pathway; Wnt signaling pathway | Scavenging of heme from plasma; Retinoid metabolism and transport | 1.65082956259427E-17 | 0.0181625429641231 | 0.133639440745791 | 0.150830220548111 | 0.925871264502428 | 0.74148782464906 | 0.901098484497789 | 30670.78727387535 | 3548407.5296101067 | 7355877.025944923 | 2243610.9879279765 | 5724840.5342227295 | ||
| Cont_P60712 | Actin, cytoplasmic 1 OS=Bos taurus OX=9913 GN=ACTB PE=1 SV=1 | 225.45 | 70 | 19 | 852 | 2 | 375 | 41.7 | cell organization and biogenesis;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component | enzyme regulator activity;cytoskeletal activity;other molecular function | 100033878; 100135470; 100173832; 101844587; 102139853; 11461; 118833809; 280979; 396526; 403580; 414396; 443052; 450133; 60; 81822 | ENSBTAG00000026199; ENSCAFG00000016020; ENSCAFG00030015381; ENSCAFG00040015695; ENSCPOG00000013467; ENSG00000075624; ENSMAUG00000008763; ENSMUSG00000029580; ENSOARG00040012985; ENSOARG00180022443; ENSOARG00185023855; ENSOARG00215030140; ENSOARG00225009314; ENSPPYG00000017336; ENSPTRG00000018890; ENSRNOG00000034254; ENSSSCG00000007585; ENSSSCG00030003451; ENSSSCG00035038792; ENSSSCG00040049462; ENSSSCG00045027458; ENSSSCG00050065025; ENSSSCG00055012597; ENSSSCG00060019124; ENSSSCG00065037921; ENSSSCG00070011353; ENSSSCG00105030144; ENSSSCG00110026965; ENSSSCG00115013637; ENSSSCG00130033784 | Actb; ACTB | A5D961; A5PKA1; bta:280979; cfa:403580; cpoc:100135470; csab:103246953; ecb:100033878; gga:396526; hsa:60; maua:101844587; mmu:11461; O18840; oas:443052; P02570; P60706; P60707; P60708; P60709; P60710; P60711; P60712; P60713; P70514; P99021; pon:100173832; ptr:450133; Q11209; Q11211; Q3SZD2; Q3TI89; Q3TVP6; Q4L0Y2; Q4R561; Q5R1X3; Q5R582; Q5R6G0; Q64316; Q6QAQ1; Q6ZWM3; Q711N9; Q71FK5; Q75MN2; Q76N69; Q8MIJ0; Q8SPX4; Q95164; Q96B34; Q96HG5; rno:81822; ssc:414396 | FAS pathway and stress induction of HSP regulation; Actin cytoskeleton regulation; Myometrial relaxation and contraction pathways; Focal adhesion; Arrhythmogenic right ventricular cardiomyopathy; Pathogenic Escherichia coli infection; Common pathways underlying drug addiction; Myometrial relaxation and contraction pathways; Focal adhesion; Fas ligand pathway and stress induction of heat shock proteins; Pathogenic Escherichia coli infection; Arrhythmogenic right ventricular cardiomyopathy; Focal adhesion; Myometrial relaxation and contraction pathways; Regulation of actin cytoskeleton; Myometrial relaxation and contraction pathways; Ebola virus infection in host; Acute viral myocarditis; Thermogenesis; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Overlap between signal transduction pathways contributing to LMNA laminopathies; Pleural mesothelioma; Regulation of actin cytoskeleton; Network map of SARS-CoV-2 signaling; Regulation of actin cytoskeleton; Regulation of actin cytoskeleton; Focal adhesion | Formation of the canonical BAF (cBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); Regulation of actin dynamics for phagocytic cup formation; EPH-ephrin mediated repulsion of cells; Formation of annular gap junctions; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; RHO GTPases Activate Formins; RHOF GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; B-WICH complex positively regulates rRNA expression; Regulation of CDH1 Function; Formation of the dystrophin-glycoprotein complex (DGC); Formation of the canonical BAF (cBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); RHO GTPases Activate WASPs and WAVEs; UCH proteinases; DNA Damage Recognition in GG-NER; Formation of the non-canonical BAF (ncBAF) complex; RHO GTPases activate IQGAPs; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Cell-extracellular matrix interactions; MAP2K and MAPK activation; Interaction between L1 and Ankyrins; RHOF GTPase cycle; DNA Damage Recognition in GG-NER; MAP2K and MAPK activation; RHO GTPases Activate Formins; Clathrin-mediated endocytosis; UCH proteinases; RHOF GTPase cycle; DNA Damage Recognition in GG-NER; EPH-ephrin mediated repulsion of cells; VEGFA-VEGFR2 Pathway; Regulation of actin dynamics for phagocytic cup formation; Adherens junctions interactions; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); RHO GTPases Activate WASPs and WAVEs; B-WICH complex positively regulates rRNA expression; Regulation of CDH1 Function; EPHB-mediated forward signaling; Formation of the non-canonical BAF (ncBAF) complex; Formation of the canonical BAF (cBAF) complex; Formation of annular gap junctions; RHO GTPases activate IQGAPs; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; RHO GTPases Activate WASPs and WAVEs; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RHO GTPases activate IQGAPs; RHO GTPases Activate Formins; RHOF GTPase cycle; Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs); B-WICH complex positively regulates rRNA expression; Signaling by BRAF and RAF1 fusions; UCH proteinases; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; VEGFA-VEGFR2 Pathway; Formation of the dystrophin-glycoprotein complex (DGC); Factors involved in megakaryocyte development and platelet production; Regulation of MITF-M-dependent genes involved in pigmentation; Formation of the canonical BAF (cBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); EPH-ephrin mediated repulsion of cells; HATs acetylate histones; Interaction between L1 and Ankyrins; Prefoldin mediated transfer of substrate to CCT/TriC; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Adherens junctions interactions; Regulation of CDH1 Function; Formation of the non-canonical BAF (ncBAF) complex; DNA Damage Recognition in GG-NER; Formation of the polybromo-BAF (pBAF) complex; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Formation of annular gap junctions; Folding of actin by CCT/TriC; Cell-extracellular matrix interactions; MAP2K and MAPK activation; RHO GTPases Activate Formins; Recycling pathway of L1; RHO GTPases activate IQGAPs; Clathrin-mediated endocytosis; Formation of the dystrophin-glycoprotein complex (DGC); EPHB-mediated forward signaling; UCH proteinases; B-WICH complex positively regulates rRNA expression; Adherens junctions interactions; Formation of the non-canonical BAF (ncBAF) complex; Formation of annular gap junctions; Formation of the polybromo-BAF (pBAF) complex; VEGFA-VEGFR2 Pathway; Cell-extracellular matrix interactions; RHO GTPases Activate WASPs and WAVEs; Regulation of CDH1 Function; Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; UCH proteinases; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); Formation of the polybromo-BAF (pBAF) complex; B-WICH complex positively regulates rRNA expression; DNA Damage Recognition in GG-NER; Formation of the canonical BAF (cBAF) complex; RHO GTPases Activate Formins; Regulation of CDH1 Function; Interaction between L1 and Ankyrins; RHOF GTPase cycle; Formation of the non-canonical BAF (ncBAF) complex; Adherens junctions interactions; Formation of the dystrophin-glycoprotein complex (DGC); VEGFA-VEGFR2 Pathway; RHO GTPases Activate WASPs and WAVEs; Cell-extracellular matrix interactions; EPHB-mediated forward signaling; MAP2K and MAPK activation; Recycling pathway of L1; RHO GTPases activate IQGAPs; Formation of annular gap junctions; B-WICH complex positively regulates rRNA expression; UCH proteinases; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); MAP2K and MAPK activation; Formation of the polybromo-BAF (pBAF) complex; RHO GTPases Activate Formins; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases Activate WASPs and WAVEs; Formation of the dystrophin-glycoprotein complex (DGC); VEGFA-VEGFR2 Pathway; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; DNA Damage Recognition in GG-NER; RHOF GTPase cycle; Cell-extracellular matrix interactions; Adherens junctions interactions; Formation of the non-canonical BAF (ncBAF) complex; Formation of the canonical BAF (cBAF) complex; RHO GTPases activate IQGAPs; Regulation of CDH1 Function; Gap junction degradation; Formation of annular gap junctions; Regulation of actin dynamics for phagocytic cup formation; RHOF GTPase cycle; Clathrin-mediated endocytosis; RHO GTPases Activate Formins; Cell-extracellular matrix interactions; VEGFA-VEGFR2 Pathway; Adherens junctions interactions; RHO GTPases activate IQGAPs; UCH proteinases; EPHB-mediated forward signaling; MAP2K and MAPK activation; RHO GTPases Activate WASPs and WAVEs; Formation of the dystrophin-glycoprotein complex (DGC); Formation of annular gap junctions; Formation of the canonical BAF (cBAF) complex; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of the non-canonical BAF (ncBAF) complex; Regulation of CDH1 Function | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.994348552930242 | 0.963278515868644 | 0.938282411159324 | 1996659.4544256767 | 4.828873920581084E7 | 6.5074451419171505E7 | 5.335770948168167E7 | 1.0984219759318356E8 | |
| P63260 | Actin, cytoplasmic 2 [OS=Mus musculus] | 217.791 | 70 | 19 | 831 | 2 | 375 | 41.8 | cell organization and biogenesis;stress response;developmental processes;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 11465 | ENSMUSG00000062825 | Actg1 | mmu:11465; P02571; P14104; P63260; P99022 | Myometrial relaxation and contraction pathways; Regulation of actin cytoskeleton; Focal adhesion | Platelet degranulation ; RHO GTPases activate IQGAPs; Adherens junctions interactions; Regulation of CDH1 Function; RHO GTPases Activate Formins; Regulation of actin dynamics for phagocytic cup formation; Interaction between L1 and Ankyrins; MAP2K and MAPK activation; Recycling pathway of L1; Clathrin-mediated endocytosis; Formation of the dystrophin-glycoprotein complex (DGC); EPHB-mediated forward signaling; RHOF GTPase cycle; Formation of annular gap junctions; VEGFA-VEGFR2 Pathway; Cell-extracellular matrix interactions; RHO GTPases Activate WASPs and WAVEs; RHOBTB2 GTPase cycle | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.901789796153066 | 0.731487178650893 | 0.819844267712751 | 145698.54484736864 | 254666.434448248 | 126248.83655432604 | 256671.2110968777 | ||
| P33434 | 72 kDa type IV collagenase [OS=Mus musculus] | 212.03 | 56 | 30 | 889 | 30 | 662 | 74.1 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes | extracellular matrix;plasma membrane;other membranes;cytoskeleton;mitochondrion;nucleus;other cell component | other molecular function | 17390 | ENSMUSG00000031740 | Mmp2 | mmu:17390; P33434 | Lung fibrosis; IL-3 signaling pathway; Matrix metalloproteinases | Collagen degradation; Extra-nuclear estrogen signaling; EPH-ephrin mediated repulsion of cells; Activation of Matrix Metalloproteinases | 0.372996577396536 | 0.964209443670126 | 0.342075680986172 | 0.708142491896103 | 0.459747209584207 | 0.34519376377552 | 0.809503222445875 | 2.5908623508144036E7 | 2.11513119484971E7 | 6.116415043649567E7 | 5.359802560613743E7 | 8.73371018908004E7 | |
| P19096 | Fatty acid synthase [OS=Mus musculus] | 203.372 | 23 | 48 | 335 | 48 | 2504 | 272.3 | other metabolic processes;stress response;other biological processes | plasma membrane;other membranes;cytosol;ER/Golgi;other cell component | other molecular function | 14104 | ENSMUSG00000025153 | Fasn | B1ATU8; mmu:14104; P19096; Q6PB72; Q8C4Z0; Q9EQR0 | Fatty acid biosynthesis; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-9 fatty acid synthesis; Elongation of (very) long chain fatty acids | Fatty acyl-CoA biosynthesis; Vitamin B5 (pantothenate) metabolism | 0.66189768147619 | 0.847457711018997 | 0.951921622352553 | 0.605074788683686 | 0.994834213681465 | 0.746782404466558 | 0.990873516209569 | 102793.32580216101 | 1389784.0897720233 | 2729524.669883373 | 892753.3234074336 | 2995475.6339221266 | |
| Cont_Q3SZ57 | Alpha-fetoprotein OS=Bos taurus OX=9913 GN=AFP PE=2 SV=1 | 202.89 | 62 | 30 | 1153 | 29 | 610 | 68.5 | other metabolic processes;developmental processes;other biological processes | non-structural extracellular;other cell component | other molecular function | 506011 | ENSBTAG00000017131 | AFP | bta:506011; Q3SZ57 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 0.540832988168188 | 0.82964085881652 | 0.605387748357992 | 0.553772240900005 | 0.15729598575093 | 0.699570390946254 | 0.323545662226049 | 3.8603879197485335E7 | 4.5317948160280704E7 | 3.6151020512819335E7 | 3.679174310656657E7 | 4.2915740009991035E7 | ||
| P48678 | Prelamin-A/C [OS=Mus musculus] | 202.607 | 60 | 37 | 529 | 36 | 665 | 74.2 | cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes | other membranes;cytoskeleton;nucleus;other cell component | other molecular function | 16905 | ENSMUSG00000028063 | Lmna | B3RH23; B3RH24; mmu:16905; P11516; P48678; P97859; Q3TIH0; Q3TTS8; Q3U733; Q3U7I5; Q3UCA0; Q3UCJ8; Q3UCU3; Q91WF2; Q9DC21 | Adipogenesis genes; FAS pathway and stress induction of HSP regulation | 1.65082956259427E-17 | 0.00670345592293191 | 0.139423967594304 | 1.70336894001643E-17 | 0.77212820363828 | 0.901149690306505 | 0.00692305873191716 | 75722.11050192213 | 4134986.871037207 | 1.1058985470826533E7 | 6289356.16248022 | 5.369543399964929E7 | ||
| Q02788 | Collagen alpha-2(VI) chain [OS=Mus musculus] | 202.37 | 41 | 36 | 585 | 36 | 1034 | 110.3 | cell adhesion;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component | other molecular function | 12834 | ENSMUSG00000020241 | Col6a2 | mmu:12834; Q02788; Q05505; Q8C972; Q8K229 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | ECM proteoglycans; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation | 0.175734701097799 | 1.8644578313253E-17 | 0.633123216104285 | 0.767312384697355 | 0.880899056945259 | 0.0961283818482991 | 0.809503222445875 | 121237.29953889274 | 4.136492509189963E7 | 5.21291258166705E7 | 1.173163988850227E7 | 2.0595787144729633E7 | |
| P97927 | Laminin subunit alpha-4 [OS=Mus musculus] | 199.33 | 30 | 41 | 409 | 41 | 1816 | 201.7 | cell adhesion;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | signal transduction activity or receptor binding | 16775 | ENSMUSG00000019846 | Lama4 | mmu:16775; O88785; P70409; P97927; Q14BF2 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Formation of the dystrophin-glycoprotein complex (DGC); Laminin interactions; MET activates PTK2 signaling | 0.496649188935323 | 0.645007535999596 | 0.952104483873957 | 0.825047045401531 | 0.929291541980042 | 0.50594120050135 | 0.819844267712751 | 390078.69973194966 | 5125646.74812024 | 1.037511250312096E7 | 3065544.409694903 | 5760601.1965567535 | |
| P20152 | Vimentin [OS=Mus musculus] | 183.446 | 60 | 29 | 762 | 27 | 466 | 53.7 | cell organization and biogenesis;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component | cytoskeletal activity;nucleic acid binding activity;other molecular function | 22352 | ENSMUSG00000026728 | Vim | mmu:22352; O08704; P20152; Q8CCH1 | Spinal cord injury; Primary focal segmental glomerulosclerosis (FSGS); Alpha 6 beta 4 integrin signaling pathway | Aggrephagy; Striated Muscle Contraction; Caspase-mediated cleavage of cytoskeletal proteins; RHOBTB1 GTPase cycle | 1.65082956259427E-17 | 0.0955146622024883 | 1.50457038391225E-17 | 0.137621774180062 | 0.0297998664849654 | 0.840672080806375 | 0.0332723373064956 | 1112472.104030337 | 7365249.698992513 | 3.3401280645601466E7 | 1.292797841903164E7 | 7.464184195594883E7 | |
| Q64727 | Vinculin [OS=Mus musculus] | 182.753 | 50 | 45 | 419 | 45 | 1066 | 116.6 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | plasma membrane;other membranes;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 22330 | ENSMUSG00000021823 | Vcl | mmu:22330; Q64727; Q8BP32; Q8BS46; Q922C5; Q922D9 | Primary focal segmental glomerulosclerosis (FSGS); IL-3 signaling pathway; Regulation of actin cytoskeleton; Integrin-mediated cell adhesion; Focal adhesion | Neutrophil degranulation; High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells; Platelet degranulation ; MAP2K and MAPK activation; Smooth Muscle Contraction; Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells; Regulation of CDH1 Function | 0.208404050858596 | 0.190838415616571 | 0.238791978742132 | 0.504745711776551 | 0.878264980963866 | 0.977491813528386 | 0.958518237573655 | 126150.06188907423 | 1953982.7579073233 | 4840837.086136207 | 2359150.5810886133 | 6758257.200309387 | |
| Q8K4G1 | Latent-transforming growth factor beta-binding protein 4 [OS=Mus musculus] | 180.216 | 27 | 29 | 318 | 29 | 1666 | 178.5 | cell-cell signaling;cell organization and biogenesis;transport;signal transduction | non-structural extracellular;extracellular matrix | other molecular function | 108075 | ENSMUSG00000040488 | Ltbp4 | E9QPD9; mmu:108075; Q8K4G0; Q8K4G1 | TGF-beta receptor signaling activates SMADs; Molecules associated with elastic fibres | 0.308350896322176 | 0.362779483059131 | 1.50457038391225E-17 | 0.170566190602959 | 0.958956615096849 | 0.703189639676216 | 0.915193515309545 | 50068.58855747415 | 1469976.6770863 | 2473680.681365607 | 2657641.7444799202 | 7291299.088613093 | ||
| Q68FD5 | Clathrin heavy chain 1 [OS=Mus musculus] | 180.117 | 32 | 43 | 363 | 43 | 1675 | 191.4 | cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes | plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component | nucleic acid binding activity;other molecular function | 67300 | ENSMUSG00000047126 | Cltc | mmu:67300; Q68FD5 | IL-7 signaling pathway; Kit receptor signaling pathway | MHC class II antigen presentation; Recycling pathway of L1; Cargo recognition for clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis; LDL clearance; Retrograde neurotrophin signalling; Formation of annular gap junctions; Lysosome Vesicle Biogenesis; WNT5A-dependent internalization of FZD4; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation; RHOU GTPase cycle; RHOV GTPase cycle | 0.4248536990637 | 0.198232028950426 | 1.50457038391225E-17 | 0.413413145615294 | 0.840666598828607 | 0.946476383814868 | 0.835383236382767 | 14581.209031729499 | 1426606.2225329466 | 2101059.0869428 | 2078296.563295177 | 6830362.818457293 | |
| P02469 | Laminin subunit beta-1 [OS=Mus musculus] | 179.863 | 27 | 40 | 429 | 39 | 1786 | 197 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;nucleus;other cell component | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 16777 | ENSMUSG00000002900 | Lamb1 | E9PXZ9; P02469 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Inflammatory response pathway; Alpha 6 beta 4 integrin signaling pathway; Focal adhesion | 0.205801242418232 | 0.341417478664423 | 0.526489846375643 | 0.891178501081124 | 0.900334730044572 | 0.356773085915651 | 0.98779298590131 | 1.0460538665187027E7 | 1.4326337702720901E7 | 1.8407714250900764E7 | 2.1078383512013834E7 | 1.149610392953332E7 | ||
| Q01853 | Transitional endoplasmic reticulum ATPase [OS=Mus musculus] | 179.055 | 52 | 32 | 411 | 32 | 806 | 89.3 | cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;other biological processes | other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;enzyme regulator activity;other molecular function | 269523 | ENSMUSG00000028452 | Vcp | mmu:269523; Q01853; Q3TFH9; Q3TIM2; Q3TXN9; Q6PI18; Q8BSR6; Q8CEG4 | IL-9 signaling pathway | RHOH GTPase cycle; Neutrophil degranulation; Protein methylation; Ovarian tumor domain proteases; Neddylation; ABC-family proteins mediated transport; Translesion Synthesis by POLH; Hedgehog ligand biogenesis; KEAP1-NFE2L2 pathway; HSF1 activation; N-glycan trimming in the ER and Calnexin/Calreticulin cycle; Josephin domain DUBs | 0.915230778358139 | 0.645007535999596 | 0.808626104853287 | 0.953867932777128 | 0.877818946381645 | 0.901149690306505 | 0.737824045087029 | 621808.5300221853 | 5338414.413398174 | 9329554.935730066 | 4463650.11042755 | 1.2770955118061693E7 | |
| Q03350 | Thrombospondin-2 [OS=Mus musculus] | 178.303 | 35 | 30 | 328 | 29 | 1172 | 129.8 | cell adhesion;other biological processes | non-structural extracellular;extracellular matrix;other cell component | other molecular function | 21826 | ENSMUSG00000023885 | Thbs2 | mmu:21826; Q03350; Q8CG21 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Signaling by PDGF; O-glycosylation of TSR domain-containing proteins | 0.425958502904743 | 0.861805134687803 | 0.49027994509233 | 0.535702081245677 | 0.900334730044572 | 0.620448351319483 | 0.80954066750699 | 1929828.2171104867 | 7439397.130180354 | 1.1102887711296873E7 | 4211942.301314384 | 1.05864549049655E7 | |
| Q80YX1 | Tenascin [OS=Mus musculus] | 175.9 | 28 | 43 | 191 | 43 | 2110 | 231.7 | cell adhesion;cell-cell signaling;cell organization and biogenesis;stress response;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | signal transduction activity or receptor binding;other molecular function | 21923 | ENSMUSG00000028364 | Tnc | mmu:21923; Q64706; Q80YX1; Q80YX2 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Integrin cell surface interactions; ECM proteoglycans; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 0.117980756369098 | 0.827773046590747 | 0.560799429150649 | 0.474732236495646 | 0.00280630917527262 | 0.00972980877962454 | 0.46732263590517 | 20862.416559578665 | 1449614.4281484466 | 1.2106484504902953E7 | 96243.5238250637 | 211010.04547923067 | |
| Q61147 | Ceruloplasmin [OS=Mus musculus] | 175.43 | 36 | 33 | 380 | 33 | 1061 | 121.1 | cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular | other molecular function | 12870 | ENSMUSG00000003617 | Cp | mmu:12870; Q61147; Q6P5C8 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Iron uptake and transport; Metal ion SLC transporters | 1.65082956259427E-17 | 0.0286042496128814 | 0.232756100865398 | 0.470567140616547 | 0.902824569867946 | 0.217345018530886 | 0.830251457557488 | 116072.0240394514 | 4703216.257241024 | 9598922.193485493 | 1756646.5467629798 | 3587720.1567995367 | ||
| Q3UQ28 | Peroxidasin homolog [OS=Mus musculus] | 173.636 | 35 | 39 | 366 | 39 | 1475 | 165 | cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes | extracellular matrix;ER/Golgi;other cell component | extracellular structural activity;other molecular function | 69675 | ENSMUSG00000020674 | Pxdn | A4FU83; E9QNQ9; mmu:69675; Q3UQ28 | Crosslinking of collagen fibrils | 0.121749369203589 | 0.199060935853007 | 0.481687712882875 | 0.64860195920101 | 0.680311384167738 | 0.622521206052951 | 0.910753558746772 | 52188.79804577449 | 3468268.863888983 | 1.0141728842991263E7 | 1748064.7562207088 | 5865453.59009746 | ||
| Q61316 | Heat shock 70 kDa protein 4 [OS=Mus musculus] | 169.044 | 48 | 31 | 300 | 31 | 841 | 94.1 | protein metabolism;other metabolic processes | other cell component | other molecular function | Hspa4 | Q61316 | Regulation of HSF1-mediated heat shock response | 0.675982462193546 | 0.947627746595709 | 0.704651587991194 | 0.760498481134506 | 0.922660568001848 | 0.905946265571965 | 0.842404289073844 | 51496.56273693644 | 1715523.4149199834 | 3885769.0116153997 | 1450318.0074060035 | 4790126.20554149 | ||||
| Cont_P02533 | Keratin, type I cytoskeletal 14 OS=Homo sapiens OX=9606 GN=KRT14 PE=1 SV=4 | 164.831 | 58 | 26 | 684 | 9 | 472 | 51.5 | cell organization and biogenesis;other biological processes | plasma membrane;cytosol;cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 3861 | ENSG00000186847 | KRT14 | hsa:3861; P02533; Q14715; Q53XY3; Q9BUE3; Q9UBN2; Q9UBN3; Q9UCY4 | Corticotropin-releasing hormone signaling | Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin; Developmental Lineage of Mammary Gland Myoepithelial Cells; Type I hemidesmosome assembly | 0.821333803243143 | 0.880930298968675 | 0.666244110962191 | 0.887279041944908 | 0.728871118050286 | 0.645534074006669 | 1.76226512549596E-4 | 6829492.454091667 | 1.0299655985485494E7 | 9892865.41378706 | 2.9333304518974166E7 | 9460012.597296894 | |
| P11499 | Heat shock protein HSP 90-beta [OS=Mus musculus] | 164.719 | 50 | 29 | 532 | 19 | 724 | 83.2 | cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component | enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function | 15516 | ENSMUSG00000023944 | Hsp90ab1 | mmu:15516; O89078; P11499; Q3UIQ7 | Focal adhesion: PI3K-Akt-mTOR signaling pathway | Neutrophil degranulation; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of actin dynamics for phagocytic cup formation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Attenuation phase; Estrogen-dependent gene expression; Sema3A PAK dependent Axon repulsion; Aryl hydrocarbon receptor signalling; DDX58/IFIH1-mediated induction of interferon-alpha/beta; HSF1 activation; RHOBTB2 GTPase cycle; The NLRP3 inflammasome | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.385192173946943 | 0.975071223710592 | 0.476079393565723 | 166033.98771248801 | 1.0807613687705928E7 | 3.193268303009924E7 | 1.1608041082716169E7 | 4.22825068683512E7 | |
| Q9JKF1 | Ras GTPase-activating-like protein IQGAP1 [OS=Mus musculus] | 163.926 | 28 | 36 | 250 | 36 | 1657 | 188.6 | cell organization and biogenesis;developmental processes;signal transduction;other biological processes | plasma membrane;other membranes;cytoskeleton;nucleus;other cell component | enzyme regulator activity;other molecular function | 29875 | ENSMUSG00000030536 | Iqgap1 | G3UW45; mmu:29875; Q9JKF1 | G13 signaling pathway; Regulation of actin cytoskeleton | RHO GTPases activate IQGAPs; Neutrophil degranulation; RAC1 GTPase cycle; RAC2 GTPase cycle; RHOA GTPase cycle; MAP2K and MAPK activation; RHOQ GTPase cycle; RHOC GTPase cycle; RHOU GTPase cycle; RHOV GTPase cycle; Nephrin family interactions | 0.930229675308081 | 0.794460986683881 | 0.787568130909409 | 0.991639536226218 | 0.941920360687835 | 0.777195460870953 | 0.924682711624237 | 58984.367745696 | 331165.4406654323 | 1068898.0084058929 | 944145.2185002686 | 3795509.9873349466 | |
| P52480 | Pyruvate kinase PKM [OS=Mus musculus] | 163.393 | 62 | 27 | 442 | 27 | 531 | 57.8 | cell organization and biogenesis;other metabolic processes;other biological processes | cytosol;ER/Golgi;nucleus;other cell component | nucleic acid binding activity;kinase activity;other molecular function | 18746 | ENSMUSG00000032294 | Pkm | mmu:18746; P52480; Q3TBV8; Q3TBW5; Q3TC59; Q3U1X3; Q3U5P6; Q4VC20; Q64484; Q91YI8; Q9CWB1 | Glycolysis and gluconeogenesis; Purine metabolism | Neutrophil degranulation; Pyruvate metabolism; Glycolysis; Regulation of pyruvate metabolism | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.972868731003358 | 0.958705855138011 | 0.959522188921769 | 224031.9482756436 | 1.1706302394897154E7 | 1.6687028973496003E7 | 1.3595916090065738E7 | 3.1698865102110166E7 | |
| P63017 | Heat shock cognate 71 kDa protein [OS=Mus musculus] | 161.557 | 53 | 28 | 572 | 23 | 646 | 70.8 | cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component | signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function | 15481 | ENSMUSG00000015656 | Hspa8 | mmu:15481; P08109; P12225; P63017; Q3U6R0; Q3U764; Q3U7D7; Q3U7E2; Q3U9B4; Q3U9G0; Q3UGM0; Q5FWJ6; Q62373; Q62374; Q62375; Q6NZD0 | Mapk signaling pathway; Exercise-induced circadian regulation | Neutrophil degranulation; mRNA Splicing - Major Pathway; Regulation of HSF1-mediated heat shock response; PKR-mediated signaling; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis; Attenuation phase; Lysosome Vesicle Biogenesis; GABA synthesis, release, reuptake and degradation; AUF1 (hnRNP D0) binds and destabilizes mRNA; Protein methylation | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.953011140807089 | 0.709593139419252 | 0.587315224195015 | 232221.67704249235 | 1.5723480869725833E7 | 2.2348098618015703E7 | 1.2001189016638666E7 | 3.440867978172333E7 | |
| Q9JHU4 | Cytoplasmic dynein 1 heavy chain 1 [OS=Mus musculus] | 161.009 | 14 | 55 | 258 | 55 | 4644 | 531.7 | cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes | cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 13424 | ENSMUSG00000018707 | Dync1h1 | E9QM71; mmu:13424; Q9JHU4 | MHC class II antigen presentation; Neutrophil degranulation; Separation of Sister Chromatids; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; COPI-mediated anterograde transport; Recruitment of NuMA to mitotic centrosomes; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-independent Golgi-to-ER retrograde traffic; Aggrephagy; Anchoring of the basal body to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; AURKA Activation by TPX2 | 0.591873375996003 | 0.826895204418257 | 0.758743075163871 | 0.936818656936794 | 0.987352798667733 | 0.695927216301667 | 0.953305976192702 | 294620.0253220563 | 451351.8596347517 | 1275535.4534856554 | 1462326.6297541 | 5162177.518126 | ||
| Q99K41 | EMILIN-1 [OS=Mus musculus] | 157.011 | 31 | 21 | 244 | 21 | 1017 | 107.5 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 100952 | ENSMUSG00000029163 | Emilin1 | mmu:100952; Q99K41 | Molecules associated with elastic fibres | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.64186124184599 | 0.0921665663508908 | 0.491906845171331 | 1671715.86234765 | 5498413.09956387 | 384416.66366236034 | 2364922.89508055 | |||
| Q61879 | Myosin-10 [OS=Mus musculus] | 146 | 19 | 31 | 236 | 20 | 1976 | 228.9 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;nucleic acid binding activity;other molecular function | 77579 | ENSMUSG00000020900 | Myh10 | mmu:77579; Q5SV63; Q61879 | Regulation of actin cytoskeleton | RHO GTPases activate PAKs | 0.705689538076567 | 0.506231596289679 | 0.676239752697828 | 0.933545599871938 | 0.990096171400123 | 0.953146340313072 | 0.921444667457376 | 123378.89612673952 | 266023.60455562966 | 458865.269073755 | 562909.3462758837 | 1089526.38375758 | |
| Cont_P00761 | Trypsin OS=Sus scrofa OX=9823 PE=1 SV=1 | 143.502 | 62 | 11 | 3859 | 10 | 231 | 24.4 | protein metabolism;other biological processes | non-structural extracellular | other molecular function | 0.254996071775817 | 0.172153475402034 | 0.357784551188889 | 0.34040294575649 | 0.740968241512781 | 0.960577895552113 | 0.148582186670595 | 5.863252009900073E9 | 3.334729419178533E9 | 2.1792138371661735E9 | 4.479417756781787E9 | 2.35988129070601E9 | |||||||
| P20029 | Endoplasmic reticulum chaperone BiP [OS=Mus musculus] | 142.966 | 48 | 25 | 434 | 23 | 655 | 72.4 | protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component | enzyme regulator activity;translation activity;other molecular function | 14828 | ENSMUSG00000026864 | Hspa5 | mmu:14828; O35642; P20029; Q3UFF2; Q61630 | Mapk signaling pathway | Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Regulation of HSF1-mediated heat shock response | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.769590657123576 | 0.985707795620743 | 0.888702680095366 | 7392689.481756757 | 8222965.927916382 | 8403011.594768586 | 1.57890948929286E7 | ||
| Cont_P13647 | Keratin, type II cytoskeletal 5 OS=Homo sapiens OX=9606 GN=KRT5 PE=1 SV=3 | 142.395 | 51 | 34 | 500 | 20 | 590 | 62.3 | cell organization and biogenesis;other biological processes | cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;cytoskeletal activity;other molecular function | 3852 | ENSG00000186081 | KRT5 | hsa:3852; P13647; Q6PI71; Q6UBJ0; Q8TA91 | Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin; Developmental Lineage of Mammary Stem Cells; Developmental Lineage of Mammary Gland Myoepithelial Cells; Type I hemidesmosome assembly | 0.786915923361782 | 0.847457711018997 | 0.707170943024881 | 0.746833150482801 | 0.714156118974909 | 0.2733017775894 | 2.49132633766938E-5 | 5615099.536380176 | 7868513.182470503 | 9974982.226041706 | 2.8752414910160065E7 | 1.3998817771053001E7 | ||
| Cont_P08779 | Keratin, type I cytoskeletal 16 OS=Homo sapiens OX=9606 GN=KRT16 PE=1 SV=4 | 140.751 | 54 | 25 | 569 | 12 | 473 | 51.2 | cell organization and biogenesis;stress response;other biological processes | plasma membrane;cytosol;cytoskeleton | cytoskeletal activity | 3868 | ENSG00000186832 | KRT16 | A8K488; hsa:3868; P08779; P30654; Q16402; Q9UBG8 | Vitamin D receptor pathway | Formation of the cornified envelope | 0.941324060398065 | 0.961351301268194 | 0.761460393544015 | 0.887279041944908 | 0.493923182294169 | 0.895302208460818 | 3.1065941501805E-4 | 1275668.1444026066 | 3908256.3409277797 | 2249474.51763106 | 5401589.786976026 | 2569640.8216647534 | |
| Cont_P02465 | Collagen alpha-2(I) chain OS=Bos taurus OX=9913 GN=COL1A2 PE=1 SV=2 | 139.99 | 18 | 19 | 445 | 3 | 1364 | 129 | non-structural extracellular;extracellular matrix | extracellular structural activity;other molecular function | 282188 | ENSBTAG00000013472 | COL1A2 | A6QP13; bta:282188; O62649; P02465 | Inflammatory response pathway; Focal adhesion | Fibronectin matrix formation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Collagen degradation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; Collagen chain trimerization; GPVI-mediated activation cascade; Platelet Aggregation (Plug Formation); Platelet Adhesion to exposed collagen; GP1b-IX-V activation signalling | 0.483779141493222 | 0.876027096029978 | 0.421836754550416 | 0.488872343346086 | 0.076245756040016 | 0.549852418071669 | 0.432748651973214 | 70110.45197339094 | 85775.39066064726 | 163731.944383145 | 48702.045776696206 | 54970.44581499727 | ||
| Cont_P12763 | Alpha-2-HS-glycoprotein OS=Bos taurus OX=9913 GN=AHSG PE=1 SV=2 | 132.772 | 50 | 16 | 1191 | 16 | 359 | 38.4 | stress response;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component | enzyme regulator activity | 280988 | AHSG | A6QLF7; bta:280988; P12763 | Neutrophil degranulation; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 0.573667790345329 | 0.793013134473823 | 0.624272910267193 | 0.36488675645736 | 0.268930374946741 | 0.335956814949331 | 0.913214993335179 | 6.882384659684638E8 | 8.712402787486216E8 | 6.41500953397899E8 | 4.440672611032756E8 | 7.064361313920757E8 | |||
| P07901 | Heat shock protein HSP 90-alpha [OS=Mus musculus] | 132.382 | 43 | 25 | 402 | 16 | 733 | 84.7 | cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component | signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function | 15519 | ENSMUSG00000021270 | Hsp90aa1 | mmu:15519; P07901 | EBV LMP1 signaling; Focal adhesion: PI3K-Akt-mTOR signaling pathway; IL-6 signaling pathway; IL-2 signaling pathway | Regulation of necroptotic cell death; Recruitment of NuMA to mitotic centrosomes; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of actin dynamics for phagocytic cup formation; Neutrophil degranulation; Downregulation of ERBB2 signaling; Anchoring of the basal body to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; AURKA Activation by TPX2; Extra-nuclear estrogen signaling; Attenuation phase; Estrogen-dependent gene expression; Sema3A PAK dependent Axon repulsion; VEGFR2 mediated vascular permeability; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation; DDX58/IFIH1-mediated induction of interferon-alpha/beta; eNOS activation; HSF1 activation; RHOBTB2 GTPase cycle; Drug-mediated inhibition of ERBB2 signaling | 1.65082956259427E-17 | 0.508730894200713 | 1.50457038391225E-17 | 0.251664970734015 | 0.788764875934969 | 0.968364585136618 | 0.745600589176001 | 138049.65358917884 | 1667357.9717776468 | 3968795.71909318 | 1606774.576019598 | 6014683.841021903 | |
| Q02819 | Nucleobindin-1 [OS=Mus musculus] | 131.152 | 51 | 21 | 299 | 21 | 459 | 53.4 | signal transduction | non-structural extracellular;other membranes;ER/Golgi | enzyme regulator activity;nucleic acid binding activity;other molecular function | 18220 | ENSMUSG00000030824 | Nucb1 | mmu:18220; Q02819; Q3TU42; Q9CWA1; Q9D8J4; Q9DBL3 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 0.130903496983571 | 0.340647566778883 | 0.397987186613988 | 0.958122559708965 | 30635.69892492515 | 5493436.34719679 | 1.9240052036173E7 | 2379424.5332984333 | 6548209.148806977 | ||
| Q91V92 | ATP-citrate synthase [OS=Mus musculus] | 129.973 | 32 | 28 | 237 | 28 | 1091 | 119.7 | other metabolic processes | cytosol | other molecular function | 104112 | ENSMUSG00000020917 | Acly | mmu:104112; Q91V92 | Fatty acid biosynthesis | Neutrophil degranulation; Fatty acyl-CoA biosynthesis | 0.230775890814232 | 0.371468864113786 | 0.437429424171984 | 0.509570119936397 | 0.98558531112136 | 0.643183834410259 | 0.922580167429744 | 27537.414327710998 | 1276919.6113413726 | 2339759.4103227933 | 644183.8162072281 | 1777761.9344937534 | |
| A2ASQ1 | Agrin [OS=Mus musculus] | 128.989 | 18 | 26 | 227 | 26 | 1950 | 207.4 | cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cell component | signal transduction activity or receptor binding;other molecular function | 11603 | ENSMUSG00000041936 | Agrn | A2ASP9; A2ASQ0; A2ASQ1; B2RWU1 | Primary focal segmental glomerulosclerosis (FSGS) | ECM proteoglycans; Retinoid metabolism and transport; Glycosaminoglycan-protein linkage region biosynthesis; HS-GAG biosynthesis; HS-GAG degradation; Formation of the dystrophin-glycoprotein complex (DGC) | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.972791368602389 | 0.686318824668434 | 0.846971399004193 | 1695001.2322350666 | 3018900.06344302 | 1028829.4241236168 | 2045725.4701757336 | ||
| Q61508 | Extracellular matrix protein 1 [OS=Mus musculus] | 127.379 | 45 | 18 | 358 | 18 | 559 | 62.8 | stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular | signal transduction activity or receptor binding;other molecular function | 13601 | ENSMUSG00000028108 | Ecm1 | mmu:13601; Q3U5Q5; Q61508 | Platelet degranulation | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 0.121600547823456 | 0.795351011232032 | 1.51989274634622E-7 | 0.592370654746194 | 74811.39241511819 | 5.132626536679041E7 | 6.196550035866306E7 | 3515293.344106073 | 1.1331897286900917E7 | ||
| Cont_P04259 | Keratin, type II cytoskeletal 6B OS=Homo sapiens OX=9606 GN=KRT6B PE=1 SV=5 | 126.901 | 47 | 30 | 442 | 4 | 564 | 60 | cell organization and biogenesis;other biological processes | cytosol;cytoskeleton | bone, tooth or skin structural activity;cytoskeletal activity | 3854 | ENSG00000185479 | KRT6B | hsa:3854; P04259; P48669 | Formation of the cornified envelope | 0.857251372850113 | 0.868132360832926 | 0.758743075163871 | 0.801271130817871 | 0.340133476321195 | 0.937453377971347 | 0.00123883404563536 | 298970.1410949 | 1156058.5455969477 | 510017.07482617133 | 1115770.6869766254 | 854901.7358096777 | ||
| P17182 | Alpha-enolase [OS=Mus musculus] | 126.804 | 60 | 19 | 244 | 16 | 434 | 47.1 | other metabolic processes;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;other cell component | nucleic acid binding activity;other molecular function | 13806; 433182 | ENSMUSG00000059040; ENSMUSG00000063524 | Eno1 | mmu:13806; mmu:433182; P17182; Q99KT7; Q9DCY7 | Glycolysis and gluconeogenesis | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.789540446904924 | 0.858218537342417 | 0.989544231571828 | 47358.53377381337 | 9473047.660860082 | 1.1146559483992001E7 | 1.3905788568310633E7 | 2.89416009584274E7 | ||
| P08113 | Endoplasmin [OS=Mus musculus] | 126.346 | 39 | 26 | 329 | 25 | 802 | 92.4 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cell component | signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function | 22027 | ENSMUSG00000020048 | Hsp90b1 | mmu:22027; P08113; P11427 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Hypoxia-dependent self-renewal of myoblasts | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Scavenging by Class A Receptors; Trafficking and processing of endosomal TLR; Interleukin-4 and Interleukin-13 signaling | 0.107476768049312 | 0.0104456807471941 | 1.50457038391225E-17 | 0.205304099107124 | 0.840785133352029 | 0.866766165039268 | 0.896996950298791 | 52582.03853978356 | 4030450.84914005 | 5006439.15200075 | 6037105.20140975 | 1.2434595462188734E7 | |
| P58252 | Elongation factor 2 [OS=Mus musculus] | 126.048 | 37 | 31 | 378 | 30 | 858 | 95.3 | cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;translational apparatus;other cell component | cytoskeletal activity;translation activity;nucleic acid binding activity;other molecular function | 13629 | ENSMUSG00000034994 | Eef2 | mmu:13629; P58252; Q544E4 | Translation factors | Neutrophil degranulation; Protein methylation; Peptide chain elongation; Synthesis of diphthamide-EEF2 | 0.299809054080284 | 0.188334321166369 | 0.471929633209224 | 0.84258396038376 | 0.97504218639442 | 0.866546043492515 | 0.950878070645738 | 229633.38558146535 | 6414138.274151959 | 1.0566307796994643E7 | 4859646.5618234025 | 1.3065706600835832E7 | |
| Cont_P02538 | Keratin, type II cytoskeletal 6A OS=Homo sapiens OX=9606 GN=KRT6A PE=1 SV=3 | 123.757 | 47 | 30 | 454 | 3 | 564 | 60 | cell organization and biogenesis;stress response;other biological processes | cytosol;cytoskeleton | bone, tooth or skin structural activity;cytoskeletal activity | 3853 | ENSG00000205420 | KRT6A | A4QPC1; hsa:3853; P02538; P48667; Q08AR4; Q6NT67; Q96CL4 | Ectoderm differentiation; Ectoderm differentiation; Pancreatic cancer subtypes | Formation of the cornified envelope | 0.892533464536408 | 0.964633336683333 | 0.745886066139481 | 0.84258396038376 | 0.574739141583974 | 0.709593139419252 | 5.66461038960431E-4 | 2182876.549653717 | 4785085.111074816 | 3779160.7730984767 | 8485501.699692694 | 3982846.61307857 | |
| P97298 | Pigment epithelium-derived factor [OS=Mus musculus] | 123.502 | 47 | 16 | 346 | 12 | 417 | 46.2 | cell cycle OR cell proliferation;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | enzyme regulator activity | 20317 | ENSMUSG00000000753 | Serpinf1 | mmu:20317; O70629; O88691; P97298 | 1.65082956259427E-17 | 0.227296093012204 | 0.434748506750565 | 0.770205086382264 | 0.174886032348437 | 0.300753028734261 | 0.891044455497809 | 462579.17347644636 | 1.46490289953418E7 | 7.121805491857927E7 | 5921015.69252881 | 1.5757205380580032E7 | |||
| Q70E20 | Sushi, nidogen and EGF-like domain-containing protein 1 [OS=Mus musculus] | 122.942 | 19 | 22 | 287 | 22 | 1403 | 151.5 | cell adhesion | non-structural extracellular;extracellular matrix | other molecular function | 208777 | Sned1 | A6H6I3; mmu:208777; Q70E20; Q810H2; Q8BMD9 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.869908412860824 | 0.817293288705596 | 0.880760468933162 | 37861.533059704365 | 3293936.3484006864 | 6267209.5561869135 | 4995161.517920501 | 1.4223395042125002E7 | ||||
| P13020 | Gelsolin [OS=Mus musculus] | 122.934 | 35 | 22 | 377 | 9 | 780 | 85.9 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 227753 | ENSMUSG00000026879 | Gsn | mmu:227753; P13020; Q3UPB1; Q8R590 | Regulation of actin cytoskeleton | Neutrophil degranulation; Caspase-mediated cleavage of cytoskeletal proteins | 0.440427841758307 | 0.396306424610341 | 0.186266168629733 | 0.379422692457324 | 0.994546642862744 | 0.709593139419252 | 0.793590033024783 | 1139775.9088509877 | 6438031.44422588 | 9825643.045518672 | 1.1033925013460701E7 | 2.9144067496602204E7 | |
| Q61398 | Procollagen C-endopeptidase enhancer 1 [OS=Mus musculus] | 120.4 | 40 | 14 | 323 | 14 | 468 | 50.1 | protein metabolism;other biological processes | enzyme regulator activity;other molecular function | 18542 | ENSMUSG00000029718 | Pcolce | mmu:18542; O35113; Q61398 | mRNA processing | Collagen biosynthesis and modifying enzymes; Crosslinking of collagen fibrils | 1.65082956259427E-17 | 1.8644578313253E-17 | 0.151224536345852 | 0.288320039261486 | 0.789540446904924 | 0.0895861566882082 | 0.711902858921665 | 84503.2651712337 | 2.52047208020085E7 | 2.958750643636163E7 | 7672570.19904635 | 1.2538308810459368E7 | ||
| P26039 | Talin-1 [OS=Mus musculus] | 118.226 | 15 | 30 | 153 | 30 | 2541 | 269.7 | cell adhesion;cell organization and biogenesis;signal transduction | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;other molecular function | 21894 | ENSMUSG00000028465 | Tln1 | A2AIM8; mmu:21894; P26039; Q8VEF0 | Primary focal segmental glomerulosclerosis (FSGS); Integrin-mediated cell adhesion; Focal adhesion | Platelet degranulation ; MAP2K and MAPK activation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; Smooth Muscle Contraction; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 0.958262397335385 | 0.994542145304377 | 0.680632778351053 | 0.738983404380581 | 0.783910800136359 | 0.87222702623065 | 0.535066779633529 | 147890.2697082064 | 165904.24421521465 | 567933.664164035 | 286851.2614141297 | 2291518.0404973766 | |
| Q8BPB5 | EGF-containing fibulin-like extracellular matrix protein 1 [OS=Mus musculus] | 117.738 | 49 | 15 | 220 | 15 | 493 | 54.9 | protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes | extracellular matrix | signal transduction activity or receptor binding;kinase activity;other molecular function | 216616 | ENSMUSG00000020467 | Efemp1 | mmu:216616; Q6Y3N6; Q8BPB5 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 0.376780684027729 | 0.983440558239231 | 0.145805028390539 | 0.982581944728745 | 29995.485006469138 | 4441372.613318663 | 7007290.288389671 | 1370373.3251651835 | 3606517.1409647237 | |||
| P09411 | Phosphoglycerate kinase 1 [OS=Mus musculus] | 116.462 | 57 | 18 | 287 | 18 | 417 | 44.5 | protein metabolism;other metabolic processes;stress response;other biological processes | non-structural extracellular;other membranes;cytosol;mitochondrion;other cell component | kinase activity;other molecular function | 18655 | ENSMUSG00000062070 | Pgk1 | mmu:18655; P09411; Q3TPE6; Q3UKV8; Q5XJE7 | Glycolysis and gluconeogenesis | Gluconeogenesis; Glycolysis | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.766862952867809 | 0.820281310709571 | 0.891044455497809 | 46750.53578358531 | 3210948.6178334034 | 3594147.655304653 | 4500077.619792943 | 1.4795712145397767E7 | |
| P27773 | Protein disulfide-isomerase A3 [OS=Mus musculus] | 115.891 | 55 | 23 | 291 | 23 | 505 | 56.6 | cell adhesion;cell organization and biogenesis;stress response;signal transduction;other biological processes | non-structural extracellular;other membranes;ER/Golgi;other cell component | nucleic acid binding activity;other molecular function | 14827 | ENSMUSG00000027248 | Pdia3 | mmu:14827; P27773; Q3TEI9; Q3TIL2; Q3UZK8; Q8C2F4; Q99LF6 | ER-Phagosome pathway; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Calnexin/calreticulin cycle | 0.9135584231482 | 0.736536116100563 | 0.498293621965442 | 0.874168055361729 | 0.862063111456553 | 0.881496352314601 | 0.939046770372612 | 196243.61956605766 | 5161827.016313557 | 6480316.532156386 | 7238345.98431998 | 1.5315044241817234E7 | ||
| P10107 | Annexin A1 [OS=Mus musculus] | 115.566 | 64 | 18 | 270 | 18 | 346 | 38.7 | cell organization and biogenesis;stress response;transport;signal transduction;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component | enzyme regulator activity;other molecular function | 16952 | ENSMUSG00000024659 | Anxa1 | mmu:16952; P10107 | Spinal cord injury; Prostaglandin synthesis and regulation | G alpha (q) signalling events; G alpha (i) signalling events; Formyl peptide receptors bind formyl peptides and many other ligands | 1.65082956259427E-17 | 0.105053536950499 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.401885831342676 | 0.529099828181544 | 0.924766494197286 | 8983.410658903753 | 1675870.316312303 | 6017153.19339518 | 4211649.667813237 | 1.08370832078509E7 | |
| Cont_Q2KJF1 | Alpha-1B-glycoprotein OS=Bos taurus OX=9913 GN=A1BG PE=1 SV=1 | 115.502 | 48 | 14 | 224 | 14 | 503 | 53.5 | signal transduction | non-structural extracellular;plasma membrane;other membranes | 518955 | A1BG | bta:518955; Q2KJF1 | Platelet degranulation ; Neutrophil degranulation | 0.635218461842139 | 0.655487072215252 | 0.641514600397631 | 0.360991986803736 | 0.696358249006924 | 0.601376052147163 | 0.891044455497809 | 9385194.584847162 | 9820849.23751892 | 8859077.038578315 | 6762503.63408608 | 1.0317459698123023E7 | ||||
| Cont_Q3MHN5 | Vitamin D-binding protein OS=Bos taurus OX=9913 GN=GC PE=2 SV=1 | 113.599 | 55 | 20 | 319 | 20 | 474 | 53.3 | other metabolic processes;transport | non-structural extracellular;other cell component | transporter activity;cytoskeletal activity;other molecular function | 530076 | GC | bta:530076; Q3MHN5 | 0.549057967251154 | 0.804331105646976 | 0.579435037816218 | 0.479472599858427 | 0.139718417146003 | 0.570795727084329 | 0.421365656927814 | 1.2784681703575822E7 | 1.5974245944817802E7 | 1.026921939097026E7 | 1.0785165311962552E7 | 1.4618596373270534E7 | ||||
| P17742 | Peptidyl-prolyl cis-trans isomerase A [OS=Mus musculus] | 113.527 | 60 | 9 | 369 | 9 | 164 | 18 | cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes | non-structural extracellular;cytosol;nucleus;other cell component | signal transduction activity or receptor binding;other molecular function | 268373 | ENSMUSG00000071866 | Ppia | mmu:268373; P17742; Q9CWJ5; Q9R137 | Neutrophil degranulation; Basigin interactions | 0.100219677394751 | 0.099382125133403 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.696358249006924 | 0.937453377971347 | 0.331144967260478 | 5533917.143041036 | 1.0145464905716315E7 | 3.610988970082183E7 | 1.0696784170781441E7 | 4.607074026803666E7 | ||
| Q69ZN7 | Myoferlin [OS=Mus musculus] | 112.647 | 22 | 36 | 227 | 36 | 2048 | 233.2 | cell organization and biogenesis;other metabolic processes;stress response;other biological processes | plasma membrane;other membranes;nucleus | other molecular function | 226101 | ENSMUSG00000048612 | Myof | mmu:226101; Q69ZN7; Q7TMG0; Q80V33; Q8BU64; Q8BU70; Q8BUC1; Q8BVY6; Q8C0D1; Q8R3B4 | 0.73657372909066 | 0.964709887217926 | 0.888974672311279 | 0.930955411749965 | 0.877818946381645 | 0.609903091678244 | 0.975029032316037 | 74563.786625436 | 322363.41862436634 | 911704.7850761963 | 1104935.9693987637 | 3065805.015040973 | |||
| P26041 | Moesin [OS=Mus musculus] | 112.068 | 47 | 28 | 353 | 19 | 577 | 67.7 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function | 17698 | ENSMUSG00000031207 | Msn | B1AX70; mmu:17698; P26041; Q3UL28; Q8BSN4 | Regulation of actin cytoskeleton | Recycling pathway of L1 | 1.65082956259427E-17 | 0.0604972675946614 | 1.50457038391225E-17 | 0.157138696252226 | 0.682171843898269 | 0.97925982662951 | 0.954396180425051 | 3564499.916018247 | 9136364.2843242 | 1.7052591672350097E7 | 1.120013397828275E7 | 1.9030746620886367E7 | |
| P05064 | Fructose-bisphosphate aldolase A [OS=Mus musculus] | 112.015 | 66 | 18 | 261 | 18 | 364 | 39.3 | cell organization and biogenesis;other metabolic processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | other molecular function | 11674 | ENSMUSG00000030695 | Aldoa | mmu:11674; P05064 | Glycolysis and gluconeogenesis | Platelet degranulation ; Neutrophil degranulation; Gluconeogenesis; Glycolysis | 0.101571037453114 | 0.00616383846364181 | 1.50457038391225E-17 | 0.0771819601934254 | 0.828577692034317 | 0.988377544628277 | 0.953305976192702 | 21908.055682018665 | 4319055.57861477 | 4893427.94836492 | 4518789.603964283 | 1.0653934694757948E7 | |
| B2RQC6 | Multifunctional protein CAD [OS=Mus musculus] | 111.853 | 18 | 32 | 111 | 32 | 2225 | 243.1 | other metabolic processes;stress response;transport;developmental processes;other biological processes | cytosol;nucleus;other cell component | kinase activity;other molecular function | 69719 | ENSMUSG00000013629 | Cad | B2RQC6; B7ZN27; mmu:69719 | Mechanisms associated with pluripotency | Pyrimidine biosynthesis | 0.69394578118832 | 0.6681512188534 | 0.666244110962191 | 0.963127218853016 | 0.968897093792999 | 0.798180783050573 | 0.621633895543644 | 34439.61575478624 | 448793.6641228067 | 957747.5456383955 | 139659.55402474166 | 452794.3373622177 | |
| Q8BND5 | Sulfhydryl oxidase 1 [OS=Mus musculus] | 111.186 | 35 | 22 | 242 | 22 | 748 | 82.7 | cell organization and biogenesis;other biological processes | non-structural extracellular;other membranes;ER/Golgi | other molecular function | 104009 | ENSMUSG00000033684 | Qsox1 | mmu:104009; Q3TDY9; Q3TE19; Q3TR29; Q3UEL4; Q8BND5; Q8K041; Q9DBL6 | Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Neutrophil degranulation | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 0.162753188077458 | 0.696358249006924 | 0.331332346840573 | 0.877612009404373 | 25068.200750320597 | 3849451.1157268733 | 1.052758137572049E7 | 1818282.5759143168 | 5040172.36278756 |
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| Accession | Description | Sum PEP Score | Biological Process | Cellular Component | Molecular Function | Entrez Gene ID | Ensembl Gene ID | Gene Symbol | Gene ID | WikiPathways | Reactome Pathways | Abundance Ratio Adj. P-Value: (LQ_6h) / (FM_control) | Abundance Ratio Adj. P-Value: (LQ_16h) / (FM_control) | FM_AVERAGE | LQ6h_AVERAGE | LQ16h_AVERAGE | FC_ LQ6h vs NC | FC_ LQ16h vs FM | |||||||
| P11276 | Fibronectin [OS=Mus musculus] | 867.353 | cell adhesion;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi | signal transduction activity or receptor binding;enzyme regulator activity;other molecular function | 14268 | ENSMUSG00000026193 | Fn1 | G5E8B8; mmu:14268; P11276; Q61567; Q61568; Q61569; Q64233; Q80UI4 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Inflammatory response pathway; Regulation of actin cytoskeleton; Comprehensive IL-17A signaling; Focal adhesion | ECM proteoglycans; Platelet degranulation ; Cell surface interactions at the vascular wall; Syndecan interactions; MAP2K and MAPK activation; Integrin cell surface interactions; Molecules associated with elastic fibres; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Fibronectin matrix formation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; Degradation of the extracellular matrix; Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells; MET activates PTK2 signaling; GPER1 signaling | 0.00584906503121538 | 0.0844744457809114 | 2.76414533778046E7 | 2.022341523870097E8 | 2.12696235413058E8 | 2.8711212743884964 | 2.9438891195215318 | |||||||
| P11087 | Collagen alpha-1(I) chain [OS=Mus musculus] | 797.017 | cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12842 | ENSMUSG00000001506 | Col1a1 | mmu:12842; P11087; Q53WT0; Q60635; Q61367; Q61427; Q63919; Q6PCL3; Q810J9 | Osteoblast signaling; Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Comprehensive IL-17A signaling; Focal adhesion | Cell surface interactions at the vascular wall; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ECM proteoglycans; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; GPVI-mediated activation cascade; GP1b-IX-V activation signalling; Platelet Adhesion to exposed collagen; Platelet Aggregation (Plug Formation); MET activates PTK2 signaling | 1.8644578313253E-17 | 1.65082956259427E-17 | 772438.0834537543 | 2.0798706453114033E8 | 5.92854376184685E8 | 8.07285879426701 | 9.58404276622316 | |||||||
| Q01149 | Collagen alpha-2(I) chain [OS=Mus musculus] | 773.662 | cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12843 | ENSMUSG00000029661 | Col1a2 | mmu:12843; Q01149; Q8CGA5 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Focal adhesion | Crosslinking of collagen fibrils; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; ECM proteoglycans; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; GPVI-mediated activation cascade; GP1b-IX-V activation signalling; Platelet Adhesion to exposed collagen; Platelet Aggregation (Plug Formation); MET activates PTK2 signaling | 1.8644578313253E-17 | 1.65082956259427E-17 | 182180.3275564673 | 1.7308392932505235E8 | 3.475967473053053E8 | 9.891888882254342 | 10.89783168612198 | |||||||
| P08121 | Collagen alpha-1(III) chain [OS=Mus musculus] | 695.631 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | extracellular matrix;other cell component | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 12825 | ENSMUSG00000026043 | Col3a1 | mmu:12825; P08121; Q61429; Q9CRN7 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Focal adhesion | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ECM proteoglycans; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; MET activates PTK2 signaling | 1.8644578313253E-17 | 1.65082956259427E-17 | 454748.1180174556 | 6.282890624937943E7 | 2.8394661715058166E8 | 7.110216987795516 | 9.286336341446717 | |||||||
| Q9QXS1 | Plectin [OS=Mus musculus] | 659.702 | cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component | cytoskeletal activity;other molecular function | 18810 | ENSMUSG00000022565 | Plec | E9QN87; mmu:18810; Q6S384; Q6S389; Q6S394; Q9CS65; Q9QUT2; Q9QXQ8; Q9QXQ9; Q9QXR0; Q9QXR1; Q9QXR2; Q9QXR3; Q9QXR4; Q9QXR5; Q9QXR6; Q9QXR7; Q9QXR8; Q9QXR9; Q9QXS0; Q9QXS1; Q9QXS2; Q9QXS3 | Alpha 6 beta 4 integrin signaling pathway; EGFR1 signaling pathway | Type I hemidesmosome assembly; Caspase-mediated cleavage of cytoskeletal proteins | 0.714932595871944 | 0.481729871164266 | 309922.514176982 | 4599273.114185064 | 1.6676006673579365E7 | 3.891426402670929 | 5.749722481744953 | |||||||
| P08122 | Collagen alpha-2(IV) chain [OS=Mus musculus] | 526.992 | RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix | extracellular structural activity | 12827 | ENSMUSG00000031503 | Col4a2 | mmu:12827; P08122; Q3B7C2; Q3TPV9; Q61375; Q66JS5; Q6RCT6; Q6RCT7; Q6U9X1; Q8BPI9; Q8BPK3; Q91VI3 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Focal adhesion | Laminin interactions; Signaling by PDGF; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions | 0.64759425713406 | 0.352816378116182 | 1393534.8123072747 | 1.3981747232493034E7 | 5.0194805286054574E7 | 3.3267237103227703 | 5.170717117454539 | |||||||
| Q3U962 | Collagen alpha-2(V) chain [OS=Mus musculus] | 518.514 | cell organization and biogenesis;developmental processes;other biological processes | extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12832 | ENSMUSG00000026042 | Col5a2 | mmu:12832; Q3TVR2; Q3U962; Q3UHK7; Q3UTT4; Q3V1J6; Q61431; Q7TMS0; Q80VS8 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions | 0.961254912149485 | 0.861384746267066 | 2.4419841082594533E7 | 1.5753424919239333E7 | 4.592471970087584E7 | -0.6323882956741324 | 0.9112171042444063 | |||||||
| Q05793 | Basement membrane-specific heparan sulfate proteoglycan core protein [OS=Mus musculus] | 507.28 | cell organization and biogenesis;transport;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;ER/Golgi | other molecular function | 15530 | Hspg2 | mmu:15530; Q05793 | 0.382764581022518 | 0.332090710292395 | 171009.25706548532 | 2.1355561683383033E7 | 4.109385814368304E7 | 6.964393610173966 | 7.908704552577742 | ||||||||||
| Q61554 | Fibrillin-1 [OS=Mus musculus] | 499.202 | cell adhesion;other metabolic processes;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 14118 | ENSMUSG00000027204 | Fbn1 | A2AQ53; mmu:14118; Q60826; Q61554 | Comprehensive IL-17A signaling | Integrin cell surface interactions; Degradation of the extracellular matrix; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; TGF-beta receptor signaling activates SMADs; Molecules associated with elastic fibres | 0.0840496117897429 | 0.0596853092747711 | 81731.837224874 | 2.17735814942991E7 | 5.216417896597137E7 | 8.057464853046588 | 9.317945570971949 | |||||||
| Q8BTM8 | Filamin-A [OS=Mus musculus] | 493.069 | cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;other molecular function | 192176 | ENSMUSG00000031328 | Flna | B7FAV0; O54934; Q7TQI1; Q8BLK1; Q8BTM8; Q8BTN7; Q8VHX5; Q8VHX8; Q99KQ2 | Mapk signaling pathway; Focal adhesion | Platelet degranulation ; Cell-extracellular matrix interactions; RHO GTPases activate PAKs; GP1b-IX-V activation signalling | 0.493514006575528 | 0.0844935092512095 | 218480.8558628913 | 4952287.405198824 | 1.1395384793048913E7 | 4.502516267694667 | 5.704798960580473 | |||||||
| P02463 | Collagen alpha-1(IV) chain [OS=Mus musculus] | 487.707 | cell organization and biogenesis;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix | extracellular structural activity;other molecular function | 12826 | ENSMUSG00000031502 | Col4a1 | mmu:12826; P02463; Q3UHJ4; Q3UJE7; Q3UQV2; Q53X35; Q6GQS7; Q6PHB5; Q99LQ8 | Spinal cord injury; Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Laminin interactions; Signaling by PDGF; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions | 0.68008321917751 | 0.604225174343649 | 262271.417553364 | 4620515.057112186 | 2.1463797748519864E7 | 4.138921184627833 | 6.3547009644888925 | |||||||
| Q60847 | Collagen alpha-1(XII) chain [OS=Mus musculus] | 480.266 | cell adhesion;developmental processes | other cell component | 12816 | ENSMUSG00000032332 | Col12a1 | mmu:12816; P70322; Q60847 | Assembly of collagen fibrils and other multimeric structures; Collagen chain trimerization; Collagen degradation | 1.8644578313253E-17 | 0.0975092237649803 | 80180.17821443231 | 5.1736330625803865E7 | 2.9952489655588504E7 | 9.33371639573238 | 8.545214585562245 | |||||||||
| Q8VDD5 | Myosin-9 [OS=Mus musculus] | 418.364 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;stress response;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;other molecular function | 17886 | ENSMUSG00000022443 | Myh9 | mmu:17886; Q3UHT9; Q3UHU4; Q6KAN6; Q811I2; Q8VDD5 | Primary focal segmental glomerulosclerosis (FSGS) | RHO GTPases activate PAKs; Regulation of actin dynamics for phagocytic cup formation | 0.0382609387499984 | 0.156498497144098 | 100319.6147091511 | 5176534.940650649 | 8067345.413832072 | 5.68931109493806 | 6.32941841059592 | |||||||
| Cont_P02453 | Collagen alpha-1(I) chain OS=Bos taurus OX=9913 GN=COL1A1 PE=1 SV=3 | 414.689 | cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | 282187 | ENSBTAG00000013103 | COL1A1 | bta:282187; P02453; Q3MHM2 | Inflammatory response pathway; Osteoblast signaling; Focal adhesion | Fibronectin matrix formation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Collagen degradation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; Collagen chain trimerization; GPVI-mediated activation cascade; Platelet Aggregation (Plug Formation); Platelet Adhesion to exposed collagen; GP1b-IX-V activation signalling | 0.579410556046386 | 0.800889767710788 | 228542.54091026666 | 3262486.7198886867 | 3910059.36528234 | 3.8354373904758865 | 4.096655873055708 | |||||||
| Cont_P02769 | Albumin OS=Bos taurus OX=9913 GN=ALB PE=1 SV=4 | 390.555 | stress response;other biological processes | non-structural extracellular;other cell component | nucleic acid binding activity;other molecular function | 280717 | ALB | A5PJX3; bta:280717; O02787; P02769; P04277; Q3SZR2 | 0.650544967914241 | 0.520832629933248 | 2.7142766432154403E9 | 2.9099571807541137E9 | 2.4034772237737E9 | 0.10043015448628909 | -0.17544463789319698 | ||||||||||
| P01027 | Complement C3 [OS=Mus musculus] | 388.541 | cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular;other cell component | signal transduction activity or receptor binding;enzyme regulator activity | 12266 | ENSMUSG00000024164 | C3 | mmu:12266; P01027; Q61370; Q80XP1 | Complement activation, classical pathway; Tyrobp causal network in microglia; Comprehensive IL-17A signaling | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade; Neutrophil degranulation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; G alpha (i) signalling events; Peptide ligand-binding receptors; Alternative complement activation; Activation of C3 and C5 | 0.729783028721347 | 0.712660037675161 | 3269916.660849947 | 1.6657146132333001E7 | 4.4549110086954266E7 | 2.348815473163776 | 3.7680708408856756 | |||||||
| Cont_Q7SIH1 | Alpha-2-macroglobulin OS=Bos taurus OX=9913 GN=A2M PE=1 SV=2 | 370.864 | non-structural extracellular | enzyme regulator activity;other molecular function | 513856 | ENSBTAG00000018137 | A2M | A8E647; bta:513856; Q7SIH1 | IL-6 signaling pathway | 0.839052280267302 | 0.688450665125024 | 5.423624331449187E7 | 7.564994624258716E7 | 7.018676700369896E7 | 0.48008180391196364 | 0.37194179744919537 | |||||||||
| Cont_Q29443 | Serotransferrin OS=Bos taurus OX=9913 GN=TF PE=2 SV=1 | 343.183 | stress response;transport;other biological processes | non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle | other molecular function | 280705 | TF | bta:280705; Q0IIK2; Q29443 | 0.964709887217926 | 0.615274986253429 | 1.48932090998098E8 | 2.32106703986673E8 | 1.5606409762411097E8 | 0.6401335422147162 | 0.06748403432742182 | ||||||||||
| Cont_P07589 | Fibronectin OS=Bos taurus OX=9913 GN=FN1 PE=1 SV=4 | 337.517 | cell adhesion;cell organization and biogenesis;stress response;developmental processes;other biological processes | non-structural extracellular | signal transduction activity or receptor binding;other molecular function | FN1 | P07589 | 0.525827426782658 | 0.714071857030863 | 166255.75410196633 | 835883.8306505851 | 952169.9232567847 | 2.329898180493011 | 2.5178147853003274 | |||||||||||
| Q80X90 | Filamin-B [OS=Mus musculus] | 335.882 | cell organization and biogenesis;stress response;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 286940 | ENSMUSG00000025278 | Flnb | E9QNV9; mmu:286940; Q80X90; Q8VHX4; Q8VHX7; Q99KY3 | ISG15 antiviral mechanism | 0.238365792894698 | 0.296944306247309 | 154624.23024854946 | 2351112.5534752235 | 6048828.490809467 | 3.926505287666639 | 5.289817436625841 | ||||||||
| Cont_P35527 | Keratin, type I cytoskeletal 9 OS=Homo sapiens OX=9606 GN=KRT9 PE=1 SV=3 | 310.424 | cell organization and biogenesis;other biological processes | cytosol;cytoskeleton | cytoskeletal activity | 3857 | ENSG00000171403 | KRT9 | hsa:3857; O00109; P35527; Q0IJ47; Q14665 | Formation of the cornified envelope | 0.73072258897653 | 0.836660982916281 | 2.9224080803851068E7 | 3.250630567014273E7 | 4.1318104811136335E7 | 0.1535619557424608 | 0.4996164340004211 | ||||||||
| Cont_P04264 | Keratin, type II cytoskeletal 1 OS=Homo sapiens OX=9606 GN=KRT1 PE=1 SV=6 | 306.58 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;other molecular function | 3848 | ENSG00000167768 | KRT1 | B2RA01; hsa:3848; P04264; P85925; P86104; Q14720; Q6GSJ0; Q9H298 | Corticotropin-releasing hormone signaling | Formation of the cornified envelope; Neutrophil degranulation; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.653826967689551 | 0.65780924735352 | 1.5397854514739665E8 | 1.3414412508194733E8 | 1.6528138436319932E8 | -0.1989454723145774 | 0.10219489843707631 | |||||||
| P06909 | Complement factor H [OS=Mus musculus] | 292.01 | cell adhesion;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes | non-structural extracellular;plasma membrane;other membranes;mitochondrion;other cell component | other molecular function | 12628 | ENSMUSG00000026365 | Cfh | mmu:12628; P06909; Q6NZK3 | Regulation of Complement cascade | 0.0359547312524068 | 0.205200089226065 | 59542.32714759521 | 1.0566840244224759E7 | 1.036081717107911E7 | 7.471412714259086 | 7.443006470545328 | ||||||||
| P16546 | Spectrin alpha chain, non-erythrocytic 1 [OS=Mus musculus] | 291.854 | cell organization and biogenesis | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 20740 | ENSMUSG00000057738 | Sptan1 | A3KGU6; A3KGU8; P16546; Q8K380; Q9CT05 | FAS pathway and stress induction of HSP regulation | Neutrophil degranulation; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Interaction between L1 and Ankyrins; COPI-mediated anterograde transport; RHOU GTPase cycle; RHOV GTPase cycle; Caspase-mediated cleavage of cytoskeletal proteins | 0.786160319109602 | 0.958962194559628 | 684626.7741473566 | 1427277.73205798 | 3976922.979229001 | 1.0598764752393854 | 2.5382630028634425 | |||||||
| Cont_P13645 | Keratin, type I cytoskeletal 10 OS=Homo sapiens OX=9606 GN=KRT10 PE=1 SV=6 | 286.713 | cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes | plasma membrane;cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;other molecular function | 3858 | ENSG00000186395 | KRT10 | hsa:3858; P13645; Q14664; Q8N175 | Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.490821286240141 | 0.600890052902075 | 1.1091978559495355E8 | 9.409796786421584E7 | 1.13950700113199E8 | -0.23728126077989872 | 0.0388930557490876 | ||||||||
| Cont_P35908 | Keratin, type II cytoskeletal 2 epidermal OS=Homo sapiens OX=9606 GN=KRT2 PE=1 SV=2 | 284.975 | cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes | plasma membrane;cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;cytoskeletal activity | 3849 | ENSG00000172867 | KRT2 | hsa:3849; P35908; Q4VAQ2 | Formation of the cornified envelope | 0.411258958244596 | 0.499413631103761 | 4.776750778997586E7 | 2.9357809740500167E7 | 3.415287514761583E7 | -0.702285269017387 | -0.4840225715664078 | ||||||||
| Q62059 | Versican core protein [OS=Mus musculus] | 279.715 | cell adhesion;developmental processes | non-structural extracellular;extracellular matrix;other cell component | other molecular function | Vcan | Q62058; Q62059; Q9CUU0 | ECM proteoglycans; Glycosaminoglycan-protein linkage region biosynthesis; CS/DS degradation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; CS-GAG biosynthesis; DS-GAG biosynthesis | 1.8644578313253E-17 | 1.65082956259427E-17 | 104188.56292801573 | 9.037034497028168E7 | 9.467651077277745E7 | 9.760508702070462 | 9.827665809842685 | ||||||||||
| P10493 | Nidogen-1 [OS=Mus musculus] | 275.191 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | other molecular function | 18073 | ENSMUSG00000005397 | Nid1 | mmu:18073; P10493; Q3TKX9; Q8BQI3; Q8C3U8; Q8C9P6 | Laminin interactions; Degradation of the extracellular matrix | 1.8644578313253E-17 | 1.65082956259427E-17 | 322455.2944414853 | 1.2120394496125467E8 | 1.2671518083095133E8 | 8.554121783692475 | 8.618274500807305 | ||||||||
| O88207 | Collagen alpha-1(V) chain [OS=Mus musculus] | 275.025 | cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes | extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12831 | ENSMUSG00000026837 | Col5a1 | A3KGE3; mmu:12831; O88207; Q3UG94; Q6F6B0 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | ECM proteoglycans; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; MET activates PTK2 signaling | 1.8644578313253E-17 | 1.65082956259427E-17 | 80388.83753211687 | 3577832.3612721 | 8562033.320911517 | 5.475946792986802 | 6.734814451334498 | |||||||
| P37889 | Fibulin-2 [OS=Mus musculus] | 269.894 | other biological processes | non-structural extracellular | other molecular function | 14115 | ENSMUSG00000064080 | Fbln2 | G5E8B3; mmu:14115; P37889; Q9WUI2 | Molecules associated with elastic fibres | 0.0640195441309023 | 1.65082956259427E-17 | 362692.0010392267 | 6.556805587417743E7 | 8.021475911820169E7 | 7.498104380777058 | 7.78897897175684 | ||||||||
| Q8VHX6 | Filamin-C [OS=Mus musculus] | 249.498 | cell organization and biogenesis;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity | 68794 | ENSMUSG00000068699 | Flnc | B2RY80; B9EKT2; mmu:68794; Q6PAI6; Q8VHX6; Q9JJ38 | Cell-extracellular matrix interactions | 0.719627996749639 | 0.562594032195739 | 406087.97266412666 | 1016453.1391661359 | 2089599.8263247435 | 1.3236795012500113 | 2.3633624781914326 | ||||||||
| Q04857 | Collagen alpha-1(VI) chain [OS=Mus musculus] | 248.981 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component | other molecular function | 12833 | ENSMUSG00000001119 | Col6a1 | mmu:12833; Q04857 | ECM proteoglycans; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Signaling by PDGF; NCAM1 interactions | 0.392208211277376 | 0.2534363617947 | 76865.2077476112 | 5.0068940213435836E7 | 6.914260176814564E7 | 9.34736947879783 | 9.813028451743143 | ||||||||
| Cont_Q2UVX4 | Complement C3 OS=Bos taurus OX=9913 GN=C3 PE=1 SV=2 | 247.154 | cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular;other cell component | signal transduction activity or receptor binding;enzyme regulator activity | 280677 | ENSBTAG00000017280 | C3 | bta:280677; Q2KIZ4; Q2UVX4 | Complement and coagulation cascades; Complement activation, classical pathway | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Neutrophil degranulation; Peptide ligand-binding receptors; G alpha (i) signalling events; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade; Alternative complement activation; Activation of C3 and C5 | 0.798729234704005 | 0.615680953989958 | 1.4686759191254234E7 | 1.84550126489547E7 | 1.5291804049274266E7 | 0.329496643269344 | 0.058242535434261965 | |||||||
| Q62261 | Spectrin beta chain, non-erythrocytic 1 [OS=Mus musculus] | 244.684 | cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 20742 | ENSMUSG00000020315 | Sptbn1 | A2AFU1; mmu:20742; Q3TEM7; Q5SQL8; Q5SQL9; Q62261; Q9QWJ7 | COPI-mediated anterograde transport; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; RHOU GTPase cycle; Interaction between L1 and Ankyrins; RHOV GTPase cycle | 0.776437620310661 | 0.69394578118832 | 492454.03878621367 | 920886.7046363313 | 2921004.358024217 | 0.9030345918205293 | 2.568403522778103 | ||||||||
| Q640N1 | Adipocyte enhancer-binding protein 1 [OS=Mus musculus] | 239.707 | protein metabolism;other biological processes | nucleus;other cell component | nucleic acid binding activity;other molecular function | 11568 | ENSMUSG00000020473 | Aebp1 | mmu:11568; O88442; Q3TVV5; Q3TWA7; Q3TX56; Q3TXB2; Q5NCI9; Q61281; Q640N1 | 0.0457359864845759 | 0.269326617826563 | 4843934.666021533 | 3.9556778473622136E7 | 4.1143769603117764E7 | 3.029673625475387 | 3.0864226685149996 | |||||||||
| P57780 | Alpha-actinin-4 [OS=Mus musculus] | 239.42 | cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes | cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 60595 | ENSMUSG00000054808 | Actn4 | mmu:60595; P57780 | Primary focal segmental glomerulosclerosis (FSGS) | Platelet degranulation | 1.8644578313253E-17 | 1.65082956259427E-17 | 20900.169415734228 | 4580996.01302682 | 9830280.285985528 | 7.7760028602441835 | 8.877574105018988 | |||||||
| Q7TPR4 | Alpha-actinin-1 [OS=Mus musculus] | 235.529 | cell adhesion;cell organization and biogenesis;other biological processes | plasma membrane;other membranes;cytoskeleton;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function | 109711 | ENSMUSG00000015143 | Actn1 | mmu:109711; Q7TPR4 | Regulation of actin cytoskeleton; Integrin-mediated cell adhesion; Focal adhesion | Platelet degranulation ; RHOF GTPase cycle; RHOBTB2 GTPase cycle; RHOD GTPase cycle; Regulation of cytoskeletal remodeling and cell spreading by IPP complex components | 0.178726136005694 | 0.995554138371554 | 486802.1989182571 | 2525588.7379033365 | 6210475.170240924 | 2.3752121425876065 | 3.673296064913109 | |||||||
| P02468 | Laminin subunit gamma-1 [OS=Mus musculus] | 230.882 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | Lamc1 | P02468 | 0.116315527815218 | 0.118212047511996 | 18104.5719498812 | 7327169.184632126 | 1.61740059690847E7 | 8.660758050441677 | 9.803107266380897 | |||||||||||
| Q91ZX7 | Prolow-density lipoprotein receptor-related protein 1 [OS=Mus musculus] | 230.497 | other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;other molecular function | 16971 | Lrp1 | mmu:16971; Q61291; Q91ZX7; Q920Y4 | Statin pathway; Wnt signaling pathway | Scavenging of heme from plasma; Retinoid metabolism and transport | 0.0181625429641231 | 1.65082956259427E-17 | 30670.78727387535 | 3548407.5296101067 | 7355877.025944923 | 6.854162701489687 | 7.9058883521099 | ||||||||
| Cont_P60712 | Actin, cytoplasmic 1 OS=Bos taurus OX=9913 GN=ACTB PE=1 SV=1 | 225.45 | cell organization and biogenesis;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component | enzyme regulator activity;cytoskeletal activity;other molecular function | 100033878; 100135470; 100173832; 101844587; 102139853; 11461; 118833809; 280979; 396526; 403580; 414396; 443052; 450133; 60; 81822 | ENSBTAG00000026199; ENSCAFG00000016020; ENSCAFG00030015381; ENSCAFG00040015695; ENSCPOG00000013467; ENSG00000075624; ENSMAUG00000008763; ENSMUSG00000029580; ENSOARG00040012985; ENSOARG00180022443; ENSOARG00185023855; ENSOARG00215030140; ENSOARG00225009314; ENSPPYG00000017336; ENSPTRG00000018890; ENSRNOG00000034254; ENSSSCG00000007585; ENSSSCG00030003451; ENSSSCG00035038792; ENSSSCG00040049462; ENSSSCG00045027458; ENSSSCG00050065025; ENSSSCG00055012597; ENSSSCG00060019124; ENSSSCG00065037921; ENSSSCG00070011353; ENSSSCG00105030144; ENSSSCG00110026965; ENSSSCG00115013637; ENSSSCG00130033784 | Actb; ACTB | A5D961; A5PKA1; bta:280979; cfa:403580; cpoc:100135470; csab:103246953; ecb:100033878; gga:396526; hsa:60; maua:101844587; mmu:11461; O18840; oas:443052; P02570; P60706; P60707; P60708; P60709; P60710; P60711; P60712; P60713; P70514; P99021; pon:100173832; ptr:450133; Q11209; Q11211; Q3SZD2; Q3TI89; Q3TVP6; Q4L0Y2; Q4R561; Q5R1X3; Q5R582; Q5R6G0; Q64316; Q6QAQ1; Q6ZWM3; Q711N9; Q71FK5; Q75MN2; Q76N69; Q8MIJ0; Q8SPX4; Q95164; Q96B34; Q96HG5; rno:81822; ssc:414396 | FAS pathway and stress induction of HSP regulation; Actin cytoskeleton regulation; Myometrial relaxation and contraction pathways; Focal adhesion; Arrhythmogenic right ventricular cardiomyopathy; Pathogenic Escherichia coli infection; Common pathways underlying drug addiction; Myometrial relaxation and contraction pathways; Focal adhesion; Fas ligand pathway and stress induction of heat shock proteins; Pathogenic Escherichia coli infection; Arrhythmogenic right ventricular cardiomyopathy; Focal adhesion; Myometrial relaxation and contraction pathways; Regulation of actin cytoskeleton; Myometrial relaxation and contraction pathways; Ebola virus infection in host; Acute viral myocarditis; Thermogenesis; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Overlap between signal transduction pathways contributing to LMNA laminopathies; Pleural mesothelioma; Regulation of actin cytoskeleton; Network map of SARS-CoV-2 signaling; Regulation of actin cytoskeleton; Regulation of actin cytoskeleton; Focal adhesion | Formation of the canonical BAF (cBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); Regulation of actin dynamics for phagocytic cup formation; EPH-ephrin mediated repulsion of cells; Formation of annular gap junctions; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; RHO GTPases Activate Formins; RHOF GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; B-WICH complex positively regulates rRNA expression; Regulation of CDH1 Function; Formation of the dystrophin-glycoprotein complex (DGC); Formation of the canonical BAF (cBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); RHO GTPases Activate WASPs and WAVEs; UCH proteinases; DNA Damage Recognition in GG-NER; Formation of the non-canonical BAF (ncBAF) complex; RHO GTPases activate IQGAPs; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Cell-extracellular matrix interactions; MAP2K and MAPK activation; Interaction between L1 and Ankyrins; RHOF GTPase cycle; DNA Damage Recognition in GG-NER; MAP2K and MAPK activation; RHO GTPases Activate Formins; Clathrin-mediated endocytosis; UCH proteinases; RHOF GTPase cycle; DNA Damage Recognition in GG-NER; EPH-ephrin mediated repulsion of cells; VEGFA-VEGFR2 Pathway; Regulation of actin dynamics for phagocytic cup formation; Adherens junctions interactions; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); RHO GTPases Activate WASPs and WAVEs; B-WICH complex positively regulates rRNA expression; Regulation of CDH1 Function; EPHB-mediated forward signaling; Formation of the non-canonical BAF (ncBAF) complex; Formation of the canonical BAF (cBAF) complex; Formation of annular gap junctions; RHO GTPases activate IQGAPs; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; RHO GTPases Activate WASPs and WAVEs; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RHO GTPases activate IQGAPs; RHO GTPases Activate Formins; RHOF GTPase cycle; Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs); B-WICH complex positively regulates rRNA expression; Signaling by BRAF and RAF1 fusions; UCH proteinases; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; VEGFA-VEGFR2 Pathway; Formation of the dystrophin-glycoprotein complex (DGC); Factors involved in megakaryocyte development and platelet production; Regulation of MITF-M-dependent genes involved in pigmentation; Formation of the canonical BAF (cBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); EPH-ephrin mediated repulsion of cells; HATs acetylate histones; Interaction between L1 and Ankyrins; Prefoldin mediated transfer of substrate to CCT/TriC; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Adherens junctions interactions; Regulation of CDH1 Function; Formation of the non-canonical BAF (ncBAF) complex; DNA Damage Recognition in GG-NER; Formation of the polybromo-BAF (pBAF) complex; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Formation of annular gap junctions; Folding of actin by CCT/TriC; Cell-extracellular matrix interactions; MAP2K and MAPK activation; RHO GTPases Activate Formins; Recycling pathway of L1; RHO GTPases activate IQGAPs; Clathrin-mediated endocytosis; Formation of the dystrophin-glycoprotein complex (DGC); EPHB-mediated forward signaling; UCH proteinases; B-WICH complex positively regulates rRNA expression; Adherens junctions interactions; Formation of the non-canonical BAF (ncBAF) complex; Formation of annular gap junctions; Formation of the polybromo-BAF (pBAF) complex; VEGFA-VEGFR2 Pathway; Cell-extracellular matrix interactions; RHO GTPases Activate WASPs and WAVEs; Regulation of CDH1 Function; Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; UCH proteinases; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); Formation of the polybromo-BAF (pBAF) complex; B-WICH complex positively regulates rRNA expression; DNA Damage Recognition in GG-NER; Formation of the canonical BAF (cBAF) complex; RHO GTPases Activate Formins; Regulation of CDH1 Function; Interaction between L1 and Ankyrins; RHOF GTPase cycle; Formation of the non-canonical BAF (ncBAF) complex; Adherens junctions interactions; Formation of the dystrophin-glycoprotein complex (DGC); VEGFA-VEGFR2 Pathway; RHO GTPases Activate WASPs and WAVEs; Cell-extracellular matrix interactions; EPHB-mediated forward signaling; MAP2K and MAPK activation; Recycling pathway of L1; RHO GTPases activate IQGAPs; Formation of annular gap junctions; B-WICH complex positively regulates rRNA expression; UCH proteinases; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); MAP2K and MAPK activation; Formation of the polybromo-BAF (pBAF) complex; RHO GTPases Activate Formins; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases Activate WASPs and WAVEs; Formation of the dystrophin-glycoprotein complex (DGC); VEGFA-VEGFR2 Pathway; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; DNA Damage Recognition in GG-NER; RHOF GTPase cycle; Cell-extracellular matrix interactions; Adherens junctions interactions; Formation of the non-canonical BAF (ncBAF) complex; Formation of the canonical BAF (cBAF) complex; RHO GTPases activate IQGAPs; Regulation of CDH1 Function; Gap junction degradation; Formation of annular gap junctions; Regulation of actin dynamics for phagocytic cup formation; RHOF GTPase cycle; Clathrin-mediated endocytosis; RHO GTPases Activate Formins; Cell-extracellular matrix interactions; VEGFA-VEGFR2 Pathway; Adherens junctions interactions; RHO GTPases activate IQGAPs; UCH proteinases; EPHB-mediated forward signaling; MAP2K and MAPK activation; RHO GTPases Activate WASPs and WAVEs; Formation of the dystrophin-glycoprotein complex (DGC); Formation of annular gap junctions; Formation of the canonical BAF (cBAF) complex; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of the non-canonical BAF (ncBAF) complex; Regulation of CDH1 Function | 1.8644578313253E-17 | 1.65082956259427E-17 | 1996659.4544256767 | 4.828873920581084E7 | 6.5074451419171505E7 | 4.596026599796858 | 5.0264310485118315 | |||||||
| P63260 | Actin, cytoplasmic 2 [OS=Mus musculus] | 217.791 | cell organization and biogenesis;stress response;developmental processes;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 11465 | ENSMUSG00000062825 | Actg1 | mmu:11465; P02571; P14104; P63260; P99022 | Myometrial relaxation and contraction pathways; Regulation of actin cytoskeleton; Focal adhesion | Platelet degranulation ; RHO GTPases activate IQGAPs; Adherens junctions interactions; Regulation of CDH1 Function; RHO GTPases Activate Formins; Regulation of actin dynamics for phagocytic cup formation; Interaction between L1 and Ankyrins; MAP2K and MAPK activation; Recycling pathway of L1; Clathrin-mediated endocytosis; Formation of the dystrophin-glycoprotein complex (DGC); EPHB-mediated forward signaling; RHOF GTPase cycle; Formation of annular gap junctions; VEGFA-VEGFR2 Pathway; Cell-extracellular matrix interactions; RHO GTPases Activate WASPs and WAVEs; RHOBTB2 GTPase cycle | 1.8644578313253E-17 | 1.65082956259427E-17 | 145698.54484736864 | 254666.434448248 | ||||||||||
| P33434 | 72 kDa type IV collagenase [OS=Mus musculus] | 212.03 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes | extracellular matrix;plasma membrane;other membranes;cytoskeleton;mitochondrion;nucleus;other cell component | other molecular function | 17390 | ENSMUSG00000031740 | Mmp2 | mmu:17390; P33434 | Lung fibrosis; IL-3 signaling pathway; Matrix metalloproteinases | Collagen degradation; Extra-nuclear estrogen signaling; EPH-ephrin mediated repulsion of cells; Activation of Matrix Metalloproteinases | 0.964209443670126 | 0.372996577396536 | 2.5908623508144036E7 | 2.11513119484971E7 | 6.116415043649567E7 | -0.292685217123521 | 1.239253938445554 | |||||||
| P19096 | Fatty acid synthase [OS=Mus musculus] | 203.372 | other metabolic processes;stress response;other biological processes | plasma membrane;other membranes;cytosol;ER/Golgi;other cell component | other molecular function | 14104 | ENSMUSG00000025153 | Fasn | B1ATU8; mmu:14104; P19096; Q6PB72; Q8C4Z0; Q9EQR0 | Fatty acid biosynthesis; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-9 fatty acid synthesis; Elongation of (very) long chain fatty acids | Fatty acyl-CoA biosynthesis; Vitamin B5 (pantothenate) metabolism | 0.847457711018997 | 0.66189768147619 | 102793.32580216101 | 1389784.0897720233 | 2729524.669883373 | 3.757042269214309 | 4.730831235531711 | |||||||
| Cont_Q3SZ57 | Alpha-fetoprotein OS=Bos taurus OX=9913 GN=AFP PE=2 SV=1 | 202.89 | other metabolic processes;developmental processes;other biological processes | non-structural extracellular;other cell component | other molecular function | 506011 | ENSBTAG00000017131 | AFP | bta:506011; Q3SZ57 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 0.82964085881652 | 0.540832988168188 | 3.8603879197485335E7 | 4.5317948160280704E7 | 3.6151020512819335E7 | 0.23133671517440235 | -0.09470945341303746 | ||||||||
| P48678 | Prelamin-A/C [OS=Mus musculus] | 202.607 | cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes | other membranes;cytoskeleton;nucleus;other cell component | other molecular function | 16905 | ENSMUSG00000028063 | Lmna | B3RH23; B3RH24; mmu:16905; P11516; P48678; P97859; Q3TIH0; Q3TTS8; Q3U733; Q3U7I5; Q3UCA0; Q3UCJ8; Q3UCU3; Q91WF2; Q9DC21 | Adipogenesis genes; FAS pathway and stress induction of HSP regulation | 0.00670345592293191 | 1.65082956259427E-17 | 75722.11050192213 | 4134986.871037207 | 1.1058985470826533E7 | 5.771024316562613 | 7.190288704425306 | ||||||||
| Q02788 | Collagen alpha-2(VI) chain [OS=Mus musculus] | 202.37 | cell adhesion;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component | other molecular function | 12834 | ENSMUSG00000020241 | Col6a2 | mmu:12834; Q02788; Q05505; Q8C972; Q8K229 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | ECM proteoglycans; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation | 1.8644578313253E-17 | 0.175734701097799 | 121237.29953889274 | 4.136492509189963E7 | 5.21291258166705E7 | 8.414430536592976 | 8.748112233779976 | |||||||
| P97927 | Laminin subunit alpha-4 [OS=Mus musculus] | 199.33 | cell adhesion;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | signal transduction activity or receptor binding | 16775 | ENSMUSG00000019846 | Lama4 | mmu:16775; O88785; P70409; P97927; Q14BF2 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Formation of the dystrophin-glycoprotein complex (DGC); Laminin interactions; MET activates PTK2 signaling | 0.645007535999596 | 0.496649188935323 | 390078.69973194966 | 5125646.74812024 | 1.037511250312096E7 | 3.715896926492177 | 4.733217948190459 | |||||||
| P20152 | Vimentin [OS=Mus musculus] | 183.446 | cell organization and biogenesis;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component | cytoskeletal activity;nucleic acid binding activity;other molecular function | 22352 | ENSMUSG00000026728 | Vim | mmu:22352; O08704; P20152; Q8CCH1 | Spinal cord injury; Primary focal segmental glomerulosclerosis (FSGS); Alpha 6 beta 4 integrin signaling pathway | Aggrephagy; Striated Muscle Contraction; Caspase-mediated cleavage of cytoskeletal proteins; RHOBTB1 GTPase cycle | 0.0955146622024883 | 1.65082956259427E-17 | 1112472.104030337 | 7365249.698992513 | 3.3401280645601466E7 | 2.7269652767818724 | 4.908062353318758 | |||||||
| Q64727 | Vinculin [OS=Mus musculus] | 182.753 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | plasma membrane;other membranes;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 22330 | ENSMUSG00000021823 | Vcl | mmu:22330; Q64727; Q8BP32; Q8BS46; Q922C5; Q922D9 | Primary focal segmental glomerulosclerosis (FSGS); IL-3 signaling pathway; Regulation of actin cytoskeleton; Integrin-mediated cell adhesion; Focal adhesion | Neutrophil degranulation; High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells; Platelet degranulation ; MAP2K and MAPK activation; Smooth Muscle Contraction; Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells; Regulation of CDH1 Function | 0.190838415616571 | 0.208404050858596 | 126150.06188907423 | 1953982.7579073233 | 4840837.086136207 | 3.9532049177000044 | 5.262043723246207 | |||||||
| Q8K4G1 | Latent-transforming growth factor beta-binding protein 4 [OS=Mus musculus] | 180.216 | cell-cell signaling;cell organization and biogenesis;transport;signal transduction | non-structural extracellular;extracellular matrix | other molecular function | 108075 | ENSMUSG00000040488 | Ltbp4 | E9QPD9; mmu:108075; Q8K4G0; Q8K4G1 | TGF-beta receptor signaling activates SMADs; Molecules associated with elastic fibres | 0.362779483059131 | 0.308350896322176 | 50068.58855747415 | 1469976.6770863 | 2473680.681365607 | 4.875743668797631 | 5.626609683578324 | ||||||||
| Q68FD5 | Clathrin heavy chain 1 [OS=Mus musculus] | 180.117 | cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes | plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component | nucleic acid binding activity;other molecular function | 67300 | ENSMUSG00000047126 | Cltc | mmu:67300; Q68FD5 | IL-7 signaling pathway; Kit receptor signaling pathway | MHC class II antigen presentation; Recycling pathway of L1; Cargo recognition for clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis; LDL clearance; Retrograde neurotrophin signalling; Formation of annular gap junctions; Lysosome Vesicle Biogenesis; WNT5A-dependent internalization of FZD4; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation; RHOU GTPase cycle; RHOV GTPase cycle | 0.198232028950426 | 0.4248536990637 | 14581.209031729499 | 1426606.2225329466 | 2101059.0869428 | 6.612333012441563 | 7.170862575755155 | |||||||
| P02469 | Laminin subunit beta-1 [OS=Mus musculus] | 179.863 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;nucleus;other cell component | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 16777 | ENSMUSG00000002900 | Lamb1 | E9PXZ9; P02469 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Inflammatory response pathway; Alpha 6 beta 4 integrin signaling pathway; Focal adhesion | 0.341417478664423 | 0.205801242418232 | 1.0460538665187027E7 | 1.4326337702720901E7 | 1.8407714250900764E7 | 0.45371270995740953 | 0.8153533483670897 | ||||||||
| Q01853 | Transitional endoplasmic reticulum ATPase [OS=Mus musculus] | 179.055 | cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;other biological processes | other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;enzyme regulator activity;other molecular function | 269523 | ENSMUSG00000028452 | Vcp | mmu:269523; Q01853; Q3TFH9; Q3TIM2; Q3TXN9; Q6PI18; Q8BSR6; Q8CEG4 | IL-9 signaling pathway | RHOH GTPase cycle; Neutrophil degranulation; Protein methylation; Ovarian tumor domain proteases; Neddylation; ABC-family proteins mediated transport; Translesion Synthesis by POLH; Hedgehog ligand biogenesis; KEAP1-NFE2L2 pathway; HSF1 activation; N-glycan trimming in the ER and Calnexin/Calreticulin cycle; Josephin domain DUBs | 0.645007535999596 | 0.915230778358139 | 621808.5300221853 | 5338414.413398174 | 9329554.935730066 | 3.101868991218387 | 3.9072659463434927 | |||||||
| Q03350 | Thrombospondin-2 [OS=Mus musculus] | 178.303 | cell adhesion;other biological processes | non-structural extracellular;extracellular matrix;other cell component | other molecular function | 21826 | ENSMUSG00000023885 | Thbs2 | mmu:21826; Q03350; Q8CG21 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Signaling by PDGF; O-glycosylation of TSR domain-containing proteins | 0.861805134687803 | 0.425958502904743 | 1929828.2171104867 | 7439397.130180354 | 1.1102887711296873E7 | 1.9467132814492152 | 2.524390613497798 | |||||||
| Q80YX1 | Tenascin [OS=Mus musculus] | 175.9 | cell adhesion;cell-cell signaling;cell organization and biogenesis;stress response;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | signal transduction activity or receptor binding;other molecular function | 21923 | ENSMUSG00000028364 | Tnc | mmu:21923; Q64706; Q80YX1; Q80YX2 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Integrin cell surface interactions; ECM proteoglycans; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 0.827773046590747 | 0.117980756369098 | 20862.416559578665 | 1449614.4281484466 | 1.2106484504902953E7 | 6.118619130163546 | 9.18065799957951 | |||||||
| Q61147 | Ceruloplasmin [OS=Mus musculus] | 175.43 | cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular | other molecular function | 12870 | ENSMUSG00000003617 | Cp | mmu:12870; Q61147; Q6P5C8 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Iron uptake and transport; Metal ion SLC transporters | 0.0286042496128814 | 1.65082956259427E-17 | 116072.0240394514 | 4703216.257241024 | 9598922.193485493 | 5.340555472510453 | 6.369780225828648 | ||||||||
| Q3UQ28 | Peroxidasin homolog [OS=Mus musculus] | 173.636 | cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes | extracellular matrix;ER/Golgi;other cell component | extracellular structural activity;other molecular function | 69675 | ENSMUSG00000020674 | Pxdn | A4FU83; E9QNQ9; mmu:69675; Q3UQ28 | Crosslinking of collagen fibrils | 0.199060935853007 | 0.121749369203589 | 52188.79804577449 | 3468268.863888983 | 1.0141728842991263E7 | 6.054331756125822 | 7.602347715901429 | ||||||||
| Q61316 | Heat shock 70 kDa protein 4 [OS=Mus musculus] | 169.044 | protein metabolism;other metabolic processes | other cell component | other molecular function | Hspa4 | Q61316 | Regulation of HSF1-mediated heat shock response | 0.947627746595709 | 0.675982462193546 | 51496.56273693644 | 1715523.4149199834 | 3885769.0116153997 | 5.058028867603881 | 6.2375801933412385 | ||||||||||
| Cont_P02533 | Keratin, type I cytoskeletal 14 OS=Homo sapiens OX=9606 GN=KRT14 PE=1 SV=4 | 164.831 | cell organization and biogenesis;other biological processes | plasma membrane;cytosol;cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 3861 | ENSG00000186847 | KRT14 | hsa:3861; P02533; Q14715; Q53XY3; Q9BUE3; Q9UBN2; Q9UBN3; Q9UCY4 | Corticotropin-releasing hormone signaling | Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin; Developmental Lineage of Mammary Gland Myoepithelial Cells; Type I hemidesmosome assembly | 0.880930298968675 | 0.821333803243143 | 6829492.454091667 | 1.0299655985485494E7 | 9892865.41378706 | 0.5927458802001806 | 0.5346100841122959 | |||||||
| P11499 | Heat shock protein HSP 90-beta [OS=Mus musculus] | 164.719 | cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component | enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function | 15516 | ENSMUSG00000023944 | Hsp90ab1 | mmu:15516; O89078; P11499; Q3UIQ7 | Focal adhesion: PI3K-Akt-mTOR signaling pathway | Neutrophil degranulation; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of actin dynamics for phagocytic cup formation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Attenuation phase; Estrogen-dependent gene expression; Sema3A PAK dependent Axon repulsion; Aryl hydrocarbon receptor signalling; DDX58/IFIH1-mediated induction of interferon-alpha/beta; HSF1 activation; RHOBTB2 GTPase cycle; The NLRP3 inflammasome | 1.8644578313253E-17 | 1.65082956259427E-17 | 166033.98771248801 | 1.0807613687705928E7 | 3.193268303009924E7 | 6.024425605817814 | 7.587411368791836 | |||||||
| Q9JKF1 | Ras GTPase-activating-like protein IQGAP1 [OS=Mus musculus] | 163.926 | cell organization and biogenesis;developmental processes;signal transduction;other biological processes | plasma membrane;other membranes;cytoskeleton;nucleus;other cell component | enzyme regulator activity;other molecular function | 29875 | ENSMUSG00000030536 | Iqgap1 | G3UW45; mmu:29875; Q9JKF1 | G13 signaling pathway; Regulation of actin cytoskeleton | RHO GTPases activate IQGAPs; Neutrophil degranulation; RAC1 GTPase cycle; RAC2 GTPase cycle; RHOA GTPase cycle; MAP2K and MAPK activation; RHOQ GTPase cycle; RHOC GTPase cycle; RHOU GTPase cycle; RHOV GTPase cycle; Nephrin family interactions | 0.794460986683881 | 0.930229675308081 | 58984.367745696 | 331165.4406654323 | 1068898.0084058929 | 2.489147563897488 | 4.1796477342414615 | |||||||
| P52480 | Pyruvate kinase PKM [OS=Mus musculus] | 163.393 | cell organization and biogenesis;other metabolic processes;other biological processes | cytosol;ER/Golgi;nucleus;other cell component | nucleic acid binding activity;kinase activity;other molecular function | 18746 | ENSMUSG00000032294 | Pkm | mmu:18746; P52480; Q3TBV8; Q3TBW5; Q3TC59; Q3U1X3; Q3U5P6; Q4VC20; Q64484; Q91YI8; Q9CWB1 | Glycolysis and gluconeogenesis; Purine metabolism | Neutrophil degranulation; Pyruvate metabolism; Glycolysis; Regulation of pyruvate metabolism | 1.8644578313253E-17 | 1.65082956259427E-17 | 224031.9482756436 | 1.1706302394897154E7 | 1.6687028973496003E7 | 5.707437157684907 | 6.218878820280579 | |||||||
| P63017 | Heat shock cognate 71 kDa protein [OS=Mus musculus] | 161.557 | cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component | signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function | 15481 | ENSMUSG00000015656 | Hspa8 | mmu:15481; P08109; P12225; P63017; Q3U6R0; Q3U764; Q3U7D7; Q3U7E2; Q3U9B4; Q3U9G0; Q3UGM0; Q5FWJ6; Q62373; Q62374; Q62375; Q6NZD0 | Mapk signaling pathway; Exercise-induced circadian regulation | Neutrophil degranulation; mRNA Splicing - Major Pathway; Regulation of HSF1-mediated heat shock response; PKR-mediated signaling; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis; Attenuation phase; Lysosome Vesicle Biogenesis; GABA synthesis, release, reuptake and degradation; AUF1 (hnRNP D0) binds and destabilizes mRNA; Protein methylation | 1.8644578313253E-17 | 1.65082956259427E-17 | 232221.67704249235 | 1.5723480869725833E7 | 2.2348098618015703E7 | 6.081274178280651 | 6.588505632754927 | |||||||
| Q9JHU4 | Cytoplasmic dynein 1 heavy chain 1 [OS=Mus musculus] | 161.009 | cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes | cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 13424 | ENSMUSG00000018707 | Dync1h1 | E9QM71; mmu:13424; Q9JHU4 | MHC class II antigen presentation; Neutrophil degranulation; Separation of Sister Chromatids; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; COPI-mediated anterograde transport; Recruitment of NuMA to mitotic centrosomes; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-independent Golgi-to-ER retrograde traffic; Aggrephagy; Anchoring of the basal body to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; AURKA Activation by TPX2 | 0.826895204418257 | 0.591873375996003 | 294620.0253220563 | 451351.8596347517 | 1275535.4534856554 | 0.6153970578330761 | 2.1141756003853147 | ||||||||
| Q99K41 | EMILIN-1 [OS=Mus musculus] | 157.011 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 100952 | ENSMUSG00000029163 | Emilin1 | mmu:100952; Q99K41 | Molecules associated with elastic fibres | 1.8644578313253E-17 | 1.65082956259427E-17 | 1671715.86234765 | 5498413.09956387 | |||||||||||
| Q61879 | Myosin-10 [OS=Mus musculus] | 146 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;nucleic acid binding activity;other molecular function | 77579 | ENSMUSG00000020900 | Myh10 | mmu:77579; Q5SV63; Q61879 | Regulation of actin cytoskeleton | RHO GTPases activate PAKs | 0.506231596289679 | 0.705689538076567 | 123378.89612673952 | 266023.60455562966 | 458865.269073755 | 1.108458619642415 | 1.8949749715174342 | |||||||
| Cont_P00761 | Trypsin OS=Sus scrofa OX=9823 PE=1 SV=1 | 143.502 | protein metabolism;other biological processes | non-structural extracellular | other molecular function | 0.172153475402034 | 0.254996071775817 | 5.863252009900073E9 | 3.334729419178533E9 | 2.1792138371661735E9 | -0.8141313613991668 | -1.4278932978551737 | |||||||||||||
| P20029 | Endoplasmic reticulum chaperone BiP [OS=Mus musculus] | 142.966 | protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component | enzyme regulator activity;translation activity;other molecular function | 14828 | ENSMUSG00000026864 | Hspa5 | mmu:14828; O35642; P20029; Q3UFF2; Q61630 | Mapk signaling pathway | Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Regulation of HSF1-mediated heat shock response | 1.8644578313253E-17 | 1.65082956259427E-17 | 7392689.481756757 | 8222965.927916382 | ||||||||||
| Cont_P13647 | Keratin, type II cytoskeletal 5 OS=Homo sapiens OX=9606 GN=KRT5 PE=1 SV=3 | 142.395 | cell organization and biogenesis;other biological processes | cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;cytoskeletal activity;other molecular function | 3852 | ENSG00000186081 | KRT5 | hsa:3852; P13647; Q6PI71; Q6UBJ0; Q8TA91 | Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin; Developmental Lineage of Mammary Stem Cells; Developmental Lineage of Mammary Gland Myoepithelial Cells; Type I hemidesmosome assembly | 0.847457711018997 | 0.786915923361782 | 5615099.536380176 | 7868513.182470503 | 9974982.226041706 | 0.4867794560282899 | 0.8290026737979193 | ||||||||
| Cont_P08779 | Keratin, type I cytoskeletal 16 OS=Homo sapiens OX=9606 GN=KRT16 PE=1 SV=4 | 140.751 | cell organization and biogenesis;stress response;other biological processes | plasma membrane;cytosol;cytoskeleton | cytoskeletal activity | 3868 | ENSG00000186832 | KRT16 | A8K488; hsa:3868; P08779; P30654; Q16402; Q9UBG8 | Vitamin D receptor pathway | Formation of the cornified envelope | 0.961351301268194 | 0.941324060398065 | 1275668.1444026066 | 3908256.3409277797 | 2249474.51763106 | 1.615272024678325 | 0.8183349524474691 | |||||||
| Cont_P02465 | Collagen alpha-2(I) chain OS=Bos taurus OX=9913 GN=COL1A2 PE=1 SV=2 | 139.99 | non-structural extracellular;extracellular matrix | extracellular structural activity;other molecular function | 282188 | ENSBTAG00000013472 | COL1A2 | A6QP13; bta:282188; O62649; P02465 | Inflammatory response pathway; Focal adhesion | Fibronectin matrix formation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Collagen degradation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; Collagen chain trimerization; GPVI-mediated activation cascade; Platelet Aggregation (Plug Formation); Platelet Adhesion to exposed collagen; GP1b-IX-V activation signalling | 0.876027096029978 | 0.483779141493222 | 70110.45197339094 | 85775.39066064726 | 163731.944383145 | 0.29093425615940965 | 1.223634381101149 | ||||||||
| Cont_P12763 | Alpha-2-HS-glycoprotein OS=Bos taurus OX=9913 GN=AHSG PE=1 SV=2 | 132.772 | stress response;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component | enzyme regulator activity | 280988 | AHSG | A6QLF7; bta:280988; P12763 | Neutrophil degranulation; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 0.793013134473823 | 0.573667790345329 | 6.882384659684638E8 | 8.712402787486216E8 | 6.41500953397899E8 | 0.3401621263323422 | -0.10145711777808486 | |||||||||
| P07901 | Heat shock protein HSP 90-alpha [OS=Mus musculus] | 132.382 | cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component | signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function | 15519 | ENSMUSG00000021270 | Hsp90aa1 | mmu:15519; P07901 | EBV LMP1 signaling; Focal adhesion: PI3K-Akt-mTOR signaling pathway; IL-6 signaling pathway; IL-2 signaling pathway | Regulation of necroptotic cell death; Recruitment of NuMA to mitotic centrosomes; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of actin dynamics for phagocytic cup formation; Neutrophil degranulation; Downregulation of ERBB2 signaling; Anchoring of the basal body to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; AURKA Activation by TPX2; Extra-nuclear estrogen signaling; Attenuation phase; Estrogen-dependent gene expression; Sema3A PAK dependent Axon repulsion; VEGFR2 mediated vascular permeability; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation; DDX58/IFIH1-mediated induction of interferon-alpha/beta; eNOS activation; HSF1 activation; RHOBTB2 GTPase cycle; Drug-mediated inhibition of ERBB2 signaling | 0.508730894200713 | 1.65082956259427E-17 | 138049.65358917884 | 1667357.9717776468 | 3968795.71909318 | 3.594304702710527 | 4.845442133334701 | |||||||
| Q02819 | Nucleobindin-1 [OS=Mus musculus] | 131.152 | signal transduction | non-structural extracellular;other membranes;ER/Golgi | enzyme regulator activity;nucleic acid binding activity;other molecular function | 18220 | ENSMUSG00000030824 | Nucb1 | mmu:18220; Q02819; Q3TU42; Q9CWA1; Q9D8J4; Q9DBL3 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 1.8644578313253E-17 | 1.65082956259427E-17 | 30635.69892492515 | 5493436.34719679 | 1.9240052036173E7 | 7.4863513149475525 | 9.294683220219179 | ||||||||
| Q91V92 | ATP-citrate synthase [OS=Mus musculus] | 129.973 | other metabolic processes | cytosol | other molecular function | 104112 | ENSMUSG00000020917 | Acly | mmu:104112; Q91V92 | Fatty acid biosynthesis | Neutrophil degranulation; Fatty acyl-CoA biosynthesis | 0.371468864113786 | 0.230775890814232 | 27537.414327710998 | 1276919.6113413726 | 2339759.4103227933 | 5.535130791068342 | 6.408823278146731 | |||||||
| A2ASQ1 | Agrin [OS=Mus musculus] | 128.989 | cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cell component | signal transduction activity or receptor binding;other molecular function | 11603 | ENSMUSG00000041936 | Agrn | A2ASP9; A2ASQ0; A2ASQ1; B2RWU1 | Primary focal segmental glomerulosclerosis (FSGS) | ECM proteoglycans; Retinoid metabolism and transport; Glycosaminoglycan-protein linkage region biosynthesis; HS-GAG biosynthesis; HS-GAG degradation; Formation of the dystrophin-glycoprotein complex (DGC) | 1.8644578313253E-17 | 1.65082956259427E-17 | 1695001.2322350666 | 3018900.06344302 | ||||||||||
| Q61508 | Extracellular matrix protein 1 [OS=Mus musculus] | 127.379 | stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular | signal transduction activity or receptor binding;other molecular function | 13601 | ENSMUSG00000028108 | Ecm1 | mmu:13601; Q3U5Q5; Q61508 | Platelet degranulation | 1.8644578313253E-17 | 1.65082956259427E-17 | 74811.39241511819 | 5.132626536679041E7 | 6.196550035866306E7 | 9.422223591696405 | 9.69399151201845 | ||||||||
| Cont_P04259 | Keratin, type II cytoskeletal 6B OS=Homo sapiens OX=9606 GN=KRT6B PE=1 SV=5 | 126.901 | cell organization and biogenesis;other biological processes | cytosol;cytoskeleton | bone, tooth or skin structural activity;cytoskeletal activity | 3854 | ENSG00000185479 | KRT6B | hsa:3854; P04259; P48669 | Formation of the cornified envelope | 0.868132360832926 | 0.857251372850113 | 298970.1410949 | 1156058.5455969477 | 510017.07482617133 | 1.9511411501265994 | 0.7705441417687864 | ||||||||
| P17182 | Alpha-enolase [OS=Mus musculus] | 126.804 | other metabolic processes;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;other cell component | nucleic acid binding activity;other molecular function | 13806; 433182 | ENSMUSG00000059040; ENSMUSG00000063524 | Eno1 | mmu:13806; mmu:433182; P17182; Q99KT7; Q9DCY7 | Glycolysis and gluconeogenesis | 1.8644578313253E-17 | 1.65082956259427E-17 | 47358.53377381337 | 9473047.660860082 | 1.1146559483992001E7 | 7.644060417133689 | 7.878758343175162 | ||||||||
| P08113 | Endoplasmin [OS=Mus musculus] | 126.346 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cell component | signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function | 22027 | ENSMUSG00000020048 | Hsp90b1 | mmu:22027; P08113; P11427 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Hypoxia-dependent self-renewal of myoblasts | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Scavenging by Class A Receptors; Trafficking and processing of endosomal TLR; Interleukin-4 and Interleukin-13 signaling | 0.0104456807471941 | 0.107476768049312 | 52582.03853978356 | 4030450.84914005 | 5006439.15200075 | 6.2602273439427725 | 6.573070961339852 | |||||||
| P58252 | Elongation factor 2 [OS=Mus musculus] | 126.048 | cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;translational apparatus;other cell component | cytoskeletal activity;translation activity;nucleic acid binding activity;other molecular function | 13629 | ENSMUSG00000034994 | Eef2 | mmu:13629; P58252; Q544E4 | Translation factors | Neutrophil degranulation; Protein methylation; Peptide chain elongation; Synthesis of diphthamide-EEF2 | 0.188334321166369 | 0.299809054080284 | 229633.38558146535 | 6414138.274151959 | 1.0566307796994643E7 | 4.8038511446429455 | 5.523995125592705 | |||||||
| Cont_P02538 | Keratin, type II cytoskeletal 6A OS=Homo sapiens OX=9606 GN=KRT6A PE=1 SV=3 | 123.757 | cell organization and biogenesis;stress response;other biological processes | cytosol;cytoskeleton | bone, tooth or skin structural activity;cytoskeletal activity | 3853 | ENSG00000205420 | KRT6A | A4QPC1; hsa:3853; P02538; P48667; Q08AR4; Q6NT67; Q96CL4 | Ectoderm differentiation; Ectoderm differentiation; Pancreatic cancer subtypes | Formation of the cornified envelope | 0.964633336683333 | 0.892533464536408 | 2182876.549653717 | 4785085.111074816 | 3779160.7730984767 | 1.1323140432879846 | 0.7918353525552961 | |||||||
| P97298 | Pigment epithelium-derived factor [OS=Mus musculus] | 123.502 | cell cycle OR cell proliferation;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | enzyme regulator activity | 20317 | ENSMUSG00000000753 | Serpinf1 | mmu:20317; O70629; O88691; P97298 | 0.227296093012204 | 1.65082956259427E-17 | 462579.17347644636 | 1.46490289953418E7 | 7.121805491857927E7 | 4.984960915629733 | 7.266398910121059 | |||||||||
| Q70E20 | Sushi, nidogen and EGF-like domain-containing protein 1 [OS=Mus musculus] | 122.942 | cell adhesion | non-structural extracellular;extracellular matrix | other molecular function | 208777 | Sned1 | A6H6I3; mmu:208777; Q70E20; Q810H2; Q8BMD9 | 1.8644578313253E-17 | 1.65082956259427E-17 | 37861.533059704365 | 3293936.3484006864 | 6267209.5561869135 | 6.442936037948125 | 7.370946594278482 | ||||||||||
| P13020 | Gelsolin [OS=Mus musculus] | 122.934 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 227753 | ENSMUSG00000026879 | Gsn | mmu:227753; P13020; Q3UPB1; Q8R590 | Regulation of actin cytoskeleton | Neutrophil degranulation; Caspase-mediated cleavage of cytoskeletal proteins | 0.396306424610341 | 0.440427841758307 | 1139775.9088509877 | 6438031.44422588 | 9825643.045518672 | 2.497869418910709 | 3.1078016243224496 | |||||||
| Q61398 | Procollagen C-endopeptidase enhancer 1 [OS=Mus musculus] | 120.4 | protein metabolism;other biological processes | enzyme regulator activity;other molecular function | 18542 | ENSMUSG00000029718 | Pcolce | mmu:18542; O35113; Q61398 | mRNA processing | Collagen biosynthesis and modifying enzymes; Crosslinking of collagen fibrils | 1.8644578313253E-17 | 1.65082956259427E-17 | 84503.2651712337 | 2.52047208020085E7 | 2.958750643636163E7 | 8.220471170449764 | 8.451765311848972 | ||||||||
| P26039 | Talin-1 [OS=Mus musculus] | 118.226 | cell adhesion;cell organization and biogenesis;signal transduction | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;other molecular function | 21894 | ENSMUSG00000028465 | Tln1 | A2AIM8; mmu:21894; P26039; Q8VEF0 | Primary focal segmental glomerulosclerosis (FSGS); Integrin-mediated cell adhesion; Focal adhesion | Platelet degranulation ; MAP2K and MAPK activation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; Smooth Muscle Contraction; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 0.994542145304377 | 0.958262397335385 | 147890.2697082064 | 165904.24421521465 | 567933.664164035 | 0.1658236593620016 | 1.9411952948940325 | |||||||
| Q8BPB5 | EGF-containing fibulin-like extracellular matrix protein 1 [OS=Mus musculus] | 117.738 | protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes | extracellular matrix | signal transduction activity or receptor binding;kinase activity;other molecular function | 216616 | ENSMUSG00000020467 | Efemp1 | mmu:216616; Q6Y3N6; Q8BPB5 | 1.8644578313253E-17 | 1.65082956259427E-17 | 29995.485006469138 | 4441372.613318663 | 7007290.288389671 | 7.210116443386737 | 7.867967494142903 | |||||||||
| P09411 | Phosphoglycerate kinase 1 [OS=Mus musculus] | 116.462 | protein metabolism;other metabolic processes;stress response;other biological processes | non-structural extracellular;other membranes;cytosol;mitochondrion;other cell component | kinase activity;other molecular function | 18655 | ENSMUSG00000062070 | Pgk1 | mmu:18655; P09411; Q3TPE6; Q3UKV8; Q5XJE7 | Glycolysis and gluconeogenesis | Gluconeogenesis; Glycolysis | 1.8644578313253E-17 | 1.65082956259427E-17 | 46750.53578358531 | 3210948.6178334034 | 3594147.655304653 | 6.10187286968957 | 6.264522969777913 | |||||||
| P27773 | Protein disulfide-isomerase A3 [OS=Mus musculus] | 115.891 | cell adhesion;cell organization and biogenesis;stress response;signal transduction;other biological processes | non-structural extracellular;other membranes;ER/Golgi;other cell component | nucleic acid binding activity;other molecular function | 14827 | ENSMUSG00000027248 | Pdia3 | mmu:14827; P27773; Q3TEI9; Q3TIL2; Q3UZK8; Q8C2F4; Q99LF6 | ER-Phagosome pathway; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Calnexin/calreticulin cycle | 0.736536116100563 | 0.9135584231482 | 196243.61956605766 | 5161827.016313557 | 6480316.532156386 | 4.717164140703168 | 5.045346629722291 | ||||||||
| P10107 | Annexin A1 [OS=Mus musculus] | 115.566 | cell organization and biogenesis;stress response;transport;signal transduction;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component | enzyme regulator activity;other molecular function | 16952 | ENSMUSG00000024659 | Anxa1 | mmu:16952; P10107 | Spinal cord injury; Prostaglandin synthesis and regulation | G alpha (q) signalling events; G alpha (i) signalling events; Formyl peptide receptors bind formyl peptides and many other ligands | 0.105053536950499 | 1.65082956259427E-17 | 8983.410658903753 | 1675870.316312303 | 6017153.19339518 | 7.543431512773922 | 9.387602086782305 | |||||||
| Cont_Q2KJF1 | Alpha-1B-glycoprotein OS=Bos taurus OX=9913 GN=A1BG PE=1 SV=1 | 115.502 | signal transduction | non-structural extracellular;plasma membrane;other membranes | 518955 | A1BG | bta:518955; Q2KJF1 | Platelet degranulation ; Neutrophil degranulation | 0.655487072215252 | 0.635218461842139 | 9385194.584847162 | 9820849.23751892 | 8859077.038578315 | 0.0654611269786279 | -0.08323025407879855 | ||||||||||
| Cont_Q3MHN5 | Vitamin D-binding protein OS=Bos taurus OX=9913 GN=GC PE=2 SV=1 | 113.599 | other metabolic processes;transport | non-structural extracellular;other cell component | transporter activity;cytoskeletal activity;other molecular function | 530076 | GC | bta:530076; Q3MHN5 | 0.804331105646976 | 0.549057967251154 | 1.2784681703575822E7 | 1.5974245944817802E7 | 1.026921939097026E7 | 0.3213315885051744 | -0.3160897225178924 | ||||||||||
| P17742 | Peptidyl-prolyl cis-trans isomerase A [OS=Mus musculus] | 113.527 | cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes | non-structural extracellular;cytosol;nucleus;other cell component | signal transduction activity or receptor binding;other molecular function | 268373 | ENSMUSG00000071866 | Ppia | mmu:268373; P17742; Q9CWJ5; Q9R137 | Neutrophil degranulation; Basigin interactions | 0.099382125133403 | 0.100219677394751 | 5533917.143041036 | 1.0145464905716315E7 | 3.610988970082183E7 | 0.8744620282868188 | 2.706021065150085 | ||||||||
| Q69ZN7 | Myoferlin [OS=Mus musculus] | 112.647 | cell organization and biogenesis;other metabolic processes;stress response;other biological processes | plasma membrane;other membranes;nucleus | other molecular function | 226101 | ENSMUSG00000048612 | Myof | mmu:226101; Q69ZN7; Q7TMG0; Q80V33; Q8BU64; Q8BU70; Q8BUC1; Q8BVY6; Q8C0D1; Q8R3B4 | 0.964709887217926 | 0.73657372909066 | 74563.786625436 | 322363.41862436634 | 911704.7850761963 | 2.1121410056571723 | 3.6120197152096933 | |||||||||
| P26041 | Moesin [OS=Mus musculus] | 112.068 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function | 17698 | ENSMUSG00000031207 | Msn | B1AX70; mmu:17698; P26041; Q3UL28; Q8BSN4 | Regulation of actin cytoskeleton | Recycling pathway of L1 | 0.0604972675946614 | 1.65082956259427E-17 | 3564499.916018247 | 9136364.2843242 | 1.7052591672350097E7 | 1.3579204878919158 | 2.258219426272545 | |||||||
| P05064 | Fructose-bisphosphate aldolase A [OS=Mus musculus] | 112.015 | cell organization and biogenesis;other metabolic processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | other molecular function | 11674 | ENSMUSG00000030695 | Aldoa | mmu:11674; P05064 | Glycolysis and gluconeogenesis | Platelet degranulation ; Neutrophil degranulation; Gluconeogenesis; Glycolysis | 0.00616383846364181 | 0.101571037453114 | 21908.055682018665 | 4319055.57861477 | 4893427.94836492 | 7.623110619104784 | 7.803240194807217 | |||||||
| B2RQC6 | Multifunctional protein CAD [OS=Mus musculus] | 111.853 | other metabolic processes;stress response;transport;developmental processes;other biological processes | cytosol;nucleus;other cell component | kinase activity;other molecular function | 69719 | ENSMUSG00000013629 | Cad | B2RQC6; B7ZN27; mmu:69719 | Mechanisms associated with pluripotency | Pyrimidine biosynthesis | 0.6681512188534 | 0.69394578118832 | 34439.61575478624 | 448793.6641228067 | 957747.5456383955 | 3.7039113570511004 | 4.797504471859518 | |||||||
| Q8BND5 | Sulfhydryl oxidase 1 [OS=Mus musculus] | 111.186 | cell organization and biogenesis;other biological processes | non-structural extracellular;other membranes;ER/Golgi | other molecular function | 104009 | ENSMUSG00000033684 | Qsox1 | mmu:104009; Q3TDY9; Q3TE19; Q3TR29; Q3UEL4; Q8BND5; Q8K041; Q9DBL6 | Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Neutrophil degranulation | 1.8644578313253E-17 | 1.65082956259427E-17 | 25068.200750320597 | 3849451.1157268733 | 1.052758137572049E7 | 7.262650488092563 | 8.714099860277624 |
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| P99026 | Proteasome subunit beta type-4 [OS=Mus musculus] | 20.698 | protein metabolism;other metabolic processes;other biological processes | cytosol;cytoskeleton;mitochondrion;nucleus;other cell component | other molecular function | 19172 | ENSMUSG00000005779 | Psmb4 | mmu:19172; P99026; Q3THC0; Q3THI3; Q3U0S0; Q3UVQ4; Q62008; Q8BK27; Q91VV7 | Proteasome degradation | ER-Phagosome pathway; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Neddylation; Asymmetric localization of PCP proteins; Degradation of AXIN; Hedgehog 'on' state; Ub-specific processing proteases; Regulation of RUNX3 expression and activity; Antigen processing: Ubiquitination & Proteasome degradation; Autodegradation of Cdh1 by Cdh1:APC/C; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; Assembly of the pre-replicative complex; CDK-mediated phosphorylation and removal of Cdc6; The role of GTSE1 in G2/M progression after G2 checkpoint; MAPK6/MAPK4 signaling; UCH proteinases; Regulation of PTEN stability and activity; ABC-family proteins mediated transport; Regulation of RAS by GAPs; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Degradation of CDH1; Regulation of ornithine decarboxylase (ODC); Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF(Skp2)-mediated degradation of p27/p21; Degradation of beta-catenin by the destruction complex; Autodegradation of the E3 ubiquitin ligase COP1; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of DVL; Hedgehog ligand biogenesis; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; GLI3 is processed to GLI3R by the proteasome; NIK-->noncanonical NF-kB signaling; Orc1 removal from chromatin; G2/M Checkpoints; Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Proteasome assembly; Degradation of CRY and PER proteins; Antigen processing: Ub, ATP-independent proteasomal degradation | 1.70336894001643E-17 | 1.50457038391225E-17 | 204032.37054784768 | 299698.2665350087 | 0.5547126796108673 | ||
| Q6NZJ6 | Eukaryotic translation initiation factor 4 gamma 1 [OS=Mus musculus] | 20.553 | protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes | cytosol;translational apparatus;nucleus;other cell component | nucleic acid binding activity;other molecular function | 208643 | ENSMUSG00000045983 | Eif4g1 | mmu:208643; Q6NZJ6; Q6NZN8; Q8BW99 | Translation factors | AUF1 (hnRNP D0) binds and destabilizes mRNA; L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Translation initiation complex formation; Ribosomal scanning and start codon recognition; mTORC1-mediated signalling; ISG15 antiviral mechanism; Deadenylation of mRNA | 1.70336894001643E-17 | 1.50457038391225E-17 | 32657.912951053364 | 414829.69304357894 | 3.667014662795308 | ||
| Q9DC51 | Guanine nucleotide-binding protein G(i) subunit alpha-3 [OS=Mus musculus] | 20.546 | other metabolic processes;signal transduction;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component | other molecular function | 14679 | ENSMUSG00000000001 | Gnai3 | A2AE36; mmu:14679; Q3TGV1; Q61019; Q9DC51 | Chemokine signaling pathway; G protein signaling pathways; Calcium regulation in cardiac cells; Signal transduction of S1P receptor | G alpha (i) signalling events; Adenylate cyclase inhibitory pathway; ADP signalling through P2Y purinoceptor 12; Extra-nuclear estrogen signaling | 1.70336894001643E-17 | 1.50457038391225E-17 | 48198.367831526906 | 172070.403587137 | 1.8359427750248059 | ||
| Q9QYB5 | Gamma-adducin [OS=Mus musculus] | 20.525 | cell organization and biogenesis;other biological processes | plasma membrane;other membranes;cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 27360 | ENSMUSG00000025026 | Add3 | mmu:27360; Q8JZT6; Q9D2M5; Q9QYB5; Q9QYB6 | Miscellaneous transport and binding events; RHOF GTPase cycle; RHOD GTPase cycle | 1.70336894001643E-17 | 1.50457038391225E-17 | 50702.50466596863 | 369236.83613034966 | 2.864417565414252 | |||
| P84091 | AP-2 complex subunit mu [OS=Mus musculus] | 20.513 | cell organization and biogenesis;transport;other biological processes | plasma membrane;other membranes;ER/Golgi;other cell component | signal transduction activity or receptor binding;other molecular function | 11773 | ENSMUSG00000022841 | Ap2m1 | mmu:11773; P20172; P53679; P84091 | MHC class II antigen presentation; Recycling pathway of L1; Cargo recognition for clathrin-mediated endocytosis; LDL clearance; Trafficking of GluR2-containing AMPA receptors; Retrograde neurotrophin signalling; Formation of annular gap junctions; WNT5A-dependent internalization of FZD4; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation | 1.70336894001643E-17 | 1.50457038391225E-17 | 123791.5403087701 | 631870.512595925 | 2.3517162146158612 | |||
| O88685 | 26S proteasome regulatory subunit 6A [OS=Mus musculus] | 20.493 | developmental processes;other biological processes | nucleus;other cell component | other molecular function | 19182 | ENSMUSG00000002102 | Psmc3 | mmu:19182; O88685; Q99JN8 | Proteasome degradation | Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Neddylation; FCERI mediated NF-kB activation; Downstream TCR signaling; Neutrophil degranulation; Activation of NF-kappaB in B cells; Asymmetric localization of PCP proteins; Degradation of AXIN; Hedgehog 'on' state; Ub-specific processing proteases; Regulation of RUNX3 expression and activity; Antigen processing: Ubiquitination & Proteasome degradation; Autodegradation of Cdh1 by Cdh1:APC/C; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Assembly of the pre-replicative complex; CDK-mediated phosphorylation and removal of Cdc6; MAPK6/MAPK4 signaling; UCH proteinases; Regulation of PTEN stability and activity; ABC-family proteins mediated transport; Regulation of RAS by GAPs; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Degradation of CDH1; Regulation of ornithine decarboxylase (ODC); Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF(Skp2)-mediated degradation of p27/p21; Degradation of beta-catenin by the destruction complex; Autodegradation of the E3 ubiquitin ligase COP1; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of DVL; Hedgehog ligand biogenesis; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; GLI3 is processed to GLI3R by the proteasome; NIK-->noncanonical NF-kB signaling; Orc1 removal from chromatin; G2/M Checkpoints; Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Proteasome assembly; Degradation of CRY and PER proteins | 1.70336894001643E-17 | 1.50457038391225E-17 | 64659.889526321465 | 383139.543007457 | 2.5669269832116237 | ||
| Q9JKR6 | Hypoxia up-regulated protein 1 [OS=Mus musculus] | 20.477 | protein metabolism;other metabolic processes;stress response;transport;other biological processes | non-structural extracellular;mitochondrion;ER/Golgi | other molecular function | 12282 | ENSMUSG00000032115 | Hyou1 | mmu:12282; Q3TAL1; Q3TZD0; Q3U1U2; Q64139; Q80X75; Q9JKR6 | Comprehensive IL-17A signaling | 1.70336894001643E-17 | 1.50457038391225E-17 | 145945.4434228691 | 425925.99907012004 | 1.5451736275160106 | |||
| Q923D2 | Flavin reductase (NADPH) [OS=Mus musculus] | 20.43 | other metabolic processes;other biological processes | plasma membrane;other membranes;cytosol;nucleus | other molecular function | 233016 | ENSMUSG00000040466 | Blvrb | mmu:233016; Q923D2 | Heme degradation; Cytoprotection by HMOX1 | 0.761365210380399 | 7668.46076478347 | 404053.425543072 | 1103453.4477812827 | 5.719465229269952 | 1.449407797292539 | ||
| Q9WUM3 | Coronin-1B [OS=Mus musculus] | 20.376 | cell organization and biogenesis;stress response;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 23789 | ENSMUSG00000024835 | Coro1b | mmu:23789; Q3UEB1; Q9CVA2; Q9WUM3 | 1.70336894001643E-17 | 1.50457038391225E-17 | 99108.64890373634 | 587273.1694921503 | 2.566948859995612 | ||||
| Q9D0K2 | Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial [OS=Mus musculus] | 20.294 | other metabolic processes;stress response;developmental processes;other biological processes | other molecular function | 67041 | ENSMUSG00000022186 | Oxct1 | mmu:67041; Q3TIW6; Q9CV92; Q9D0K2 | Synthesis and degradation of ketone bodies | Mitochondrial protein degradation; Utilization of Ketone Bodies | 1.70336894001643E-17 | 1.50457038391225E-17 | 213888.9951384427 | 281550.78550417 | 0.3965329199864723 | |||
| Q9QUM9 | Proteasome subunit alpha type-6 [OS=Mus musculus] | 20.25 | protein metabolism;other metabolic processes;other biological processes | cytosol;cytoskeleton;mitochondrion;translational apparatus;nucleus;other cell component | nucleic acid binding activity;other molecular function | 26443 | ENSMUSG00000021024 | Psma6 | mmu:26443; Q0VGS3; Q3TT07; Q3U6Y2; Q9QUM9 | Proteasome degradation | ER-Phagosome pathway; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Neddylation; Asymmetric localization of PCP proteins; Degradation of AXIN; Hedgehog 'on' state; Ub-specific processing proteases; Regulation of RUNX3 expression and activity; Antigen processing: Ubiquitination & Proteasome degradation; Autodegradation of Cdh1 by Cdh1:APC/C; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; Assembly of the pre-replicative complex; CDK-mediated phosphorylation and removal of Cdc6; The role of GTSE1 in G2/M progression after G2 checkpoint; MAPK6/MAPK4 signaling; UCH proteinases; Regulation of PTEN stability and activity; ABC-family proteins mediated transport; Regulation of RAS by GAPs; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Degradation of CDH1; Regulation of ornithine decarboxylase (ODC); Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF(Skp2)-mediated degradation of p27/p21; Degradation of beta-catenin by the destruction complex; Autodegradation of the E3 ubiquitin ligase COP1; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of DVL; Hedgehog ligand biogenesis; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; GLI3 is processed to GLI3R by the proteasome; NIK-->noncanonical NF-kB signaling; Orc1 removal from chromatin; G2/M Checkpoints; Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Proteasome assembly; Antigen processing: Ub, ATP-independent proteasomal degradation; Degradation of CRY and PER proteins | 0.282826664902969 | 1.50457038391225E-17 | 13591.4879910301 | 253077.76071185767 | 614362.0729556943 | 4.218805420157403 | 1.2795084196983704 |
| P56812 | Programmed cell death protein 5 [OS=Mus musculus] | 20.24 | other biological processes | nucleus;other cell component | nucleic acid binding activity | 56330 | ENSMUSG00000030417 | Pdcd5 | mmu:56330; P56812 | 0.157005440927277 | 0.0539707457045745 | 599778.372906475 | 265780.4119201703 | 282102.56443333864 | -1.1741947201983156 | 0.08598499913695021 | ||
| P98064 | Mannan-binding lectin serine protease 1 [OS=Mus musculus] | 20.214 | protein metabolism;stress response | non-structural extracellular;cytosol;nucleus | other molecular function | 17174 | ENSMUSG00000022887 | Masp1 | A2RRH8; A2RRH9; mmu:17174; P98064; Q8CD27; Q8CIR8; Q920S0 | Complement activation, classical pathway | Initial triggering of complement; Scavenging by Class A Receptors; Ficolins bind to repetitive carbohydrate structures on the target cell surface | 0.261005842756763 | 0.177965783684532 | 20022.23837906688 | 101244.58670559444 | 268762.8382132973 | 2.338169598884747 | 1.4084888979667658 |
| P61205 | ADP-ribosylation factor 3 [OS=Mus musculus] | 20.211 | transport | ER/Golgi;other cell component | other molecular function | 11842 | ENSMUSG00000051853 | Arf3 | mmu:11842; P16587; P61205 | COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; Synthesis of PIPs at the Golgi membrane | 0.946368853179788 | 0.646232544613082 | 97468.25345945806 | 396161.81723623833 | 1194142.8761891571 | 2.0230855394969174 | 1.5918137191723263 | |
| P11859 | Angiotensinogen [OS=Mus musculus] | 20.193 | cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | non-structural extracellular | signal transduction activity or receptor binding;enzyme regulator activity | Agt | P11859 | G alpha (q) signalling events; G alpha (i) signalling events; Metabolism of Angiotensinogen to Angiotensins; Peptide ligand-binding receptors | 0.923907182333523 | 0.487929216117899 | 70326.2161982151 | 109887.84931346915 | 244306.36995268136 | 0.6438973688771028 | 1.152659609150982 | |||
| Q9EPL8 | Importin-7 [OS=Mus musculus] | 20.135 | stress response;transport;other biological processes | cytosol;nucleus;other cell component | other molecular function | 233726 | ENSMUSG00000066232 | Ipo7 | mmu:233726; Q7TN09; Q7TQ63; Q8BKD8; Q8BYI0; Q9EPL8 | Mechanisms associated with pluripotency | 1.70336894001643E-17 | 1.50457038391225E-17 | 18509.5849786433 | 141982.72434860168 | 2.9393709488516713 | |||
| P70398 | Ubiquitin carboxyl-terminal hydrolase 9X [OS=Mus musculus] | 20.121 | cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | cytosol;cytoskeleton;other cell component | other molecular function | 22284 | Usp9x | E9QLY0; mmu:22284; P70398; Q62497 | RHOU GTPase cycle; RHOV GTPase cycle; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Ub-specific processing proteases; Peroxisomal protein import; Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 1.70336894001643E-17 | 1.50457038391225E-17 | 13230.8428443583 | 283839.766505751 | 4.423099854295974 | ||||
| Cont_Q9TT36 | Thyroxine-binding globulin OS=Bos taurus OX=9913 GN=SERPINA7 PE=2 SV=1 | 20.107 | non-structural extracellular | enzyme regulator activity | 282518 | SERPINA7 | bta:282518; Q9TT36 | 0.474382102623887 | 0.545178983856956 | 1203052.532342352 | 1093392.0488483915 | 1043339.0809385027 | -0.1378888510279398 | -0.06760268534540245 | ||||
| O55143 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [OS=Mus musculus] | 20.05 | cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes | other membranes;cytosol;ER/Golgi;other cell component | transporter activity;nucleic acid binding activity;other molecular function | 11938 | ENSMUSG00000029467 | Atp2a2 | mmu:11938; O55143; Q9R2A9; Q9WUT5 | Alzheimer's disease; Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells | Ion homeostasis; Ion transport by P-type ATPases; Reduction of cytosolic Ca++ levels | 1.70336894001643E-17 | 1.50457038391225E-17 | 34007.88939361762 | 178601.34744476833 | 2.392801587781282 | ||
| P62827 | GTP-binding nuclear protein Ran [OS=Mus musculus] | 20.033 | cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes | cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component | nucleic acid binding activity;other molecular function | 19384 | ENSMUSG00000029430 | Ran | mmu:19384; P17080; P28746; P28747; P62827; Q3U954; Q811M2; Q86V08; Q9CSP3; Q9CWI7; Q9CZA2; Q9UDJ5; Q9UEU9 | Transcriptional regulation by small RNAs; Postmitotic nuclear pore complex (NPC) reformation; Regulation of cholesterol biosynthesis by SREBP (SREBF) | 1.70336894001643E-17 | 1.50457038391225E-17 | 6998.39736366797 | 703605.9509011643 | 1633566.7622596668 | 6.651599292516778 | 1.215185827619 | |
| P51912 | Neutral amino acid transporter B(0) [OS=Mus musculus] | 20.016 | cell organization and biogenesis;transport | plasma membrane;other membranes;other cell component | transporter activity;other molecular function | Slc1a5 | P51912; Q61326 | RAC1 GTPase cycle; RHOQ GTPase cycle; RHOH GTPase cycle; RAC3 GTPase cycle; Amino acid transport across the plasma membrane | 0.971489814526882 | 0.891790050413663 | 306066.78066311067 | 866259.8859565483 | 1034567.4740003155 | 1.5009534430407643 | 0.25615592332994946 | |||
| P20108 | Thioredoxin-dependent peroxide reductase, mitochondrial [OS=Mus musculus] | 20 | cell organization and biogenesis;other metabolic processes;stress response;other biological processes | plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component | enzyme regulator activity;other molecular function | 11757 | ENSMUSG00000024997 | Prdx3 | mmu:11757; P20108 | Oxidative stress and redox pathway | Detoxification of Reactive Oxygen Species | 0.441758350709928 | 0.646232544613082 | 38276.7284089894 | 561978.0127485996 | 579053.236448066 | 3.875974256380011 | 0.04318230498033612 |
| Q9JMA1 | Ubiquitin carboxyl-terminal hydrolase 14 [OS=Mus musculus] | 19.986 | cell-cell signaling;protein metabolism;other metabolic processes;stress response;other biological processes | plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component | enzyme regulator activity;other molecular function | 59025 | ENSMUSG00000047879 | Usp14 | mmu:59025; Q543U5; Q923F2; Q9D0L0; Q9JMA1 | Ub-specific processing proteases; Regulation of NF-kappa B signaling | 0.250942353982195 | 0.152226763216414 | 5277.53004802672 | 92264.25679264004 | 372392.8490640537 | 4.127837062702827 | 2.0129816089499144 | |
| Q9Z1N5 | Spliceosome RNA helicase Ddx39b [OS=Mus musculus] | 19.947 | cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport | nucleus;other cell component | nucleic acid binding activity;other molecular function | 53817 | ENSMUSG00000019432 | Ddx39b | mmu:53817; Q8HW97; Q9Z1N5 | miRNAs and TFs in iPS Cell Generation; mRNA processing | mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; RHOBTB2 GTPase cycle | 1.70336894001643E-17 | 1.50457038391225E-17 | 336884.35184140434 | 1279453.2908593935 | 1.9252021572578506 | ||
| P63323 | Small ribosomal subunit protein eS12 [OS=Mus musculus] | 19.931 | protein metabolism;other metabolic processes;other biological processes | cytosol;translational apparatus;nucleus;other cell component | other molecular function | 20042 | ENSMUSG00000061983 | Rps12 | mmu:20042; P09388; P12728; P63323; Q6ZWZ6 | Cytoplasmic ribosomal proteins | L13a-mediated translational silencing of Ceruloplasmin expression; SRP-dependent cotranslational protein targeting to membrane; Major pathway of rRNA processing in the nucleolus and cytosol; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition | 1.70336894001643E-17 | 0.525330814660026 | 23028.57718698613 | 133269.1024881374 | 890751.7372622766 | 2.532845157850049 | 2.7406810516849722 |
| Q9WTM5 | RuvB-like 2 [OS=Mus musculus] | 19.883 | cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes | other membranes;cytosol;cytoskeleton;nucleus;other cell component | nucleic acid binding activity;other molecular function | 20174 | ENSMUSG00000003868 | Ruvbl2 | mmu:20174; Q9WTM5 | 0.328798481418023 | 0.540846430148919 | 108321.1335053103 | 205659.25190378734 | 612927.553911458 | 0.9249412342912688 | 1.575460586829122 | ||
| P35980 | Large ribosomal subunit protein eL18 [OS=Mus musculus] | 19.864 | protein metabolism;other metabolic processes | cytosol;ER/Golgi;translational apparatus;other cell component | other molecular function | 19899 | ENSMUSG00000059070 | Rpl18 | mmu:19899; P35980; Q9CQF1; Q9D987 | Cytoplasmic ribosomal proteins | L13a-mediated translational silencing of Ceruloplasmin expression; SRP-dependent cotranslational protein targeting to membrane; Major pathway of rRNA processing in the nucleolus and cytosol; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.857166540588821 | 0.663046281695812 | 1004397.2317852931 | 2064286.3401508632 | 2565776.7998820366 | 1.0393131454402196 | 0.31375257108602206 |
| Q9QUK9 | Trypsin-5 [OS=Mus musculus] | 19.853 | protein metabolism | other cell component | other molecular function | 103964 | ENSMUSG00000036938 | Try5 | mmu:103964; Q9QUK9 | Neutrophil degranulation; Antimicrobial peptides; Alpha-defensins; Activation of Matrix Metalloproteinases | 0.801271130817871 | 0.827536988704287 | 2.8547318843102765E8 | 2.7826550638723224E8 | 2.0308513055322537E8 | -0.03689317019512306 | -0.4543774716638487 | |
| P62715 | Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [OS=Mus musculus] | 19.851 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes | cytosol;cytoskeleton;nucleus;other cell component | other molecular function | 19053 | ENSMUSG00000009630 | Ppp2cb | mmu:19053; P11082; P62715 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Glycogen metabolism; IL-6 signaling pathway; Exercise-induced circadian regulation; Wnt signaling pathway and pluripotency | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Co-stimulation by CD28; Co-inhibition by CTLA4; Cyclin D associated events in G1; Cyclin A/B1/B2 associated events during G2/M transition; Separation of Sister Chromatids; PKR-mediated signaling; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Negative regulation of MAPK pathway; DARPP-32 events; Platelet sensitization by LDL; Spry regulation of FGF signaling; RAF activation; Regulation of TP53 Degradation; Beta-catenin phosphorylation cascade; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Inhibition of replication initiation of damaged DNA by RB1/E2F1; ERKs are inactivated | 1.50457038391225E-17 | 2679.5853481743998 | 35746.39536528427 | 353732.5990643203 | 3.7377160955896955 | 3.30678950588595 | |
| P43277 | Histone H1.3 [OS=Mus musculus] | 19.84 | cell organization and biogenesis;other biological processes | nucleus;other cell component | nucleic acid binding activity;other molecular function | 14957 | ENSMUSG00000052565 | H1-3 | mmu:14957; P43277; Q8C6M4 | 0.576382059704095 | 0.388186598780447 | 57369.96967728326 | 265982.08071036666 | 513015.79708017496 | 2.212961393647763 | 0.9476741966007788 | ||
| P0DOV2 | Interferon-activable protein 204 [OS=Mus musculus] | 19.773 | stress response;signal transduction;other biological processes | nucleus;other cell component | nucleic acid binding activity;other molecular function | 15951 | ENSMUSG00000073489 | Ifi204 | B7ZNS3; mmu:15951; P0DOV2; P15092; Q08619; Q3TM07; Q3U776; Q3U7F4; Q3U7K5; Q3UCH9; Q8C4X3; Q921V9 | Neutrophil degranulation | 0.113741840011805 | 1.50457038391225E-17 | 7452.67647852135 | 313923.4562517723 | 1127927.9851634176 | 5.396510386921859 | 1.8451902231699062 | |
| P63001 | Ras-related C3 botulinum toxin substrate 1 [OS=Mus musculus] | 19.748 | cell adhesion;cell-cell signaling;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component | other molecular function | 19353 | ENSMUSG00000001847 | Rac1 | mmu:19353; O95501; P15154; P63001; Q9BTB4 | IL-5 signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; BDNF pathway; Chemokine signaling pathway; G13 signaling pathway; p38 Mapk signaling pathway; Microglia pathogen phagocytosis pathway; IL-3 signaling pathway; Robo4 and VEGF signaling pathways crosstalk; IL-6 signaling pathway; Wnt signaling; Oxidative stress and redox pathway; Alpha 6 beta 4 integrin signaling pathway; Mapk signaling pathway; Na/K-ATPase/Src signaling; Regulation of actin cytoskeleton; Comprehensive IL-17A signaling; Wnt signaling pathway; EGFR1 signaling pathway; Integrin-mediated cell adhesion; Insulin signaling; Focal adhesion | Neutrophil degranulation; Ephrin signaling; MAPK6/MAPK4 signaling; RHO GTPases Activate Formins; PIP3 activates AKT signaling; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Signaling by SCF-KIT; Azathioprine ADME; Factors involved in megakaryocyte development and platelet production; Regulation of actin dynamics for phagocytic cup formation; FCERI mediated MAPK activation; RAC1 GTPase cycle; NRAGE signals death through JNK; RHO GTPases activate IQGAPs; EPHB-mediated forward signaling; Signal transduction by L1; GPVI-mediated activation cascade; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; RHO GTPases activate CIT; EPH-ephrin mediated repulsion of cells; RHO GTPases activate PAKs; Sema3A PAK dependent Axon repulsion; DAP12 signaling; Sema4D mediated inhibition of cell attachment and migration; RHO GTPases Activate NADPH Oxidases; PCP/CE pathway; RHO GTPases activate PKNs; RHO GTPases activate KTN1; CD28 dependent Vav1 pathway; VEGFR2 mediated vascular permeability; RHO GTPases Activate WASPs and WAVEs; DCC mediated attractive signaling; NTRK2 activates RAC1; MET activates RAP1 and RAC1 | 0.451941591680043 | 0.200350311233591 | 150444.07838908074 | 709584.9850638476 | 2280395.183328617 | 2.237748160249034 | 1.6842364719053984 |
| Q61543 | Golgi apparatus protein 1 [OS=Mus musculus] | 19.729 | protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes | extracellular matrix;plasma membrane;other membranes;cytoskeleton;ER/Golgi | 20340 | ENSMUSG00000003316 | Glg1 | mmu:20340; Q61543; Q9QZ40 | Cell surface interactions at the vascular wall | 0.777651129733939 | 0.789717838260029 | 56208.599478797994 | 120182.44886965571 | 295410.373243395 | 1.096363450451407 | 1.2974942627567767 | ||
| P52927 | High mobility group protein HMGI-C [OS=Mus musculus] | 19.622 | cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | nucleus;other cell component | nucleic acid binding activity;other molecular function | 15364 | ENSMUSG00000056758 | Hmga2 | mmu:15364; P52927; Q3UQW0 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 1.70336894001643E-17 | 1.50457038391225E-17 | 670127.3225753898 | 876849.6054455055 | 0.3878941870677906 | |||
| P62983 | Ubiquitin-ribosomal protein eS31 fusion protein [OS=Mus musculus] | 19.598 | protein metabolism;other metabolic processes;other biological processes | cytosol;ER/Golgi;translational apparatus;nucleus;other cell component | other molecular function | 78294 | ENSMUSG00000020460 | Rps27a | mmu:78294; P02248; P02249; P02250; P49664; P62983; P62991; Q29120; Q62317; Q64223; Q8VCH1; Q91887; Q91888; Q9CXY4; Q9CZM0; Q9D1R5; Q9D2W3; Q9D8D9; Q9ET23; Q9ET24; Q9Z0H9 | Cytoplasmic ribosomal proteins | Spry regulation of FGF signaling; Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE); Regulation of TP53 Activity through Phosphorylation; DNA Damage Recognition in GG-NER; Formation of Incision Complex in GG-NER; N-glycan trimming in the ER and Calnexin/Calreticulin cycle; Josephin domain DUBs; UCH proteinases; L13a-mediated translational silencing of Ceruloplasmin expression; SRP-dependent cotranslational protein targeting to membrane; Major pathway of rRNA processing in the nucleolus and cytosol; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Downregulation of ERBB2:ERBB3 signaling; Ovarian tumor domain proteases; Neddylation; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; Recognition of DNA damage by PCNA-containing replication complex; Dual Incision in GG-NER; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Regulation of TP53 Activity through Methylation; Downregulation of TGF-beta receptor signaling; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Asymmetric localization of PCP proteins; Degradation of AXIN; Hedgehog 'on' state; Ub-specific processing proteases; Regulation of RUNX3 expression and activity; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Cyclin B; Autodegradation of Cdh1 by Cdh1:APC/C; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; APC-Cdc20 mediated degradation of Nek2A; Separation of Sister Chromatids; Senescence-Associated Secretory Phenotype (SASP); Assembly of the pre-replicative complex; CDK-mediated phosphorylation and removal of Cdc6; Fanconi Anemia Pathway; Stimuli-sensing channels; Regulation of PLK1 Activity at G2/M Transition; EGFR downregulation; Negative regulation of MAPK pathway; The role of GTSE1 in G2/M progression after G2 checkpoint; Aggrephagy; Cargo recognition for clathrin-mediated endocytosis; MAPK6/MAPK4 signaling; E3 ubiquitin ligases ubiquitinate target proteins; Peroxisomal protein import; PINK1-PRKN Mediated Mitophagy; Regulation of PTEN stability and activity; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; Metalloprotease DUBs; ABC-family proteins mediated transport; Iron uptake and transport; Regulation of NF-kappa B signaling; Regulation of RAS by GAPs; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Degradation of CDH1; RAS processing; Translesion Synthesis by POLH; NOD1/2 Signaling Pathway; Interferon alpha/beta signaling; VLDLR internalisation and degradation; Regulation of PTEN localization; Regulation of necroptotic cell death; IKK complex recruitment mediated by RIP1; Regulation of signaling by CBL; Pexophagy; Negative regulation of FLT3; HDR through Homologous Recombination (HRR); Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; SCF(Skp2)-mediated degradation of p27/p21; Degradation of beta-catenin by the destruction complex; Autodegradation of the E3 ubiquitin ligase COP1; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of DVL; Hedgehog ligand biogenesis; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; GLI3 is processed to GLI3R by the proteasome; NIK-->noncanonical NF-kB signaling; Orc1 removal from chromatin; G2/M Checkpoints; Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; KEAP1-NFE2L2 pathway; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Degradation of CRY and PER proteins; Deactivation of the beta-catenin transactivating complex; Oxidative Stress Induced Senescence; activated TAK1 mediates p38 MAPK activation; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Cyclin D associated events in G1; NOTCH3 Activation and Transmission of Signal to the Nucleus; Regulation of TP53 Degradation; Oncogene Induced Senescence; Termination of translesion DNA synthesis; Gap-filling DNA repair synthesis and ligation in GG-NER; Inactivation of CSF3 (G-CSF) signaling; p75NTR recruits signalling complexes; NF-kB is activated and signals survival; TAK1-dependent IKK and NF-kappa-B activation ; MAP3K8 (TPL2)-dependent MAPK1/3 activation; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; Regulation of FZD by ubiquitination; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); Negative regulation of MET activity; Endosomal Sorting Complex Required For Transport (ESCRT); Regulation of expression of SLITs and ROBOs; Regulation of pyruvate metabolism; NRIF signals cell death from the nucleus; Downregulation of ERBB4 signaling; Translesion synthesis by REV1; SCF-beta-TrCP mediated degradation of Emi1; Activated NOTCH1 Transmits Signal to the Nucleus; Regulation of innate immune responses to cytosolic DNA; Translesion synthesis by POLK; Translesion synthesis by POLI; PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; ER Quality Control Compartment (ERQC); Negative regulators of DDX58/IFIH1 signaling; IRAK2 mediated activation of TAK1 complex; TRAF6-mediated induction of TAK1 complex within TLR4 complex; Alpha-protein kinase 1 signaling pathway; Regulation of BACH1 activity; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 0.162483953437847 | 1.50457038391225E-17 | 424754.39455003635 | 5034088.373055943 | 1.002796790431043E7 | 3.5670297642661697 | 0.9942268355363376 |
| Q8BM72 | Heat shock 70 kDa protein 13 [OS=Mus musculus] | 19.579 | protein metabolism;other metabolic processes | ER/Golgi | other molecular function | 110920 | ENSMUSG00000032932 | Hspa13 | mmu:110920; Q3TII6; Q8BM72; Q9D1X5 | Regulation of HSF1-mediated heat shock response | 1.70336894001643E-17 | 1.50457038391225E-17 | 248297.92722047333 | 277132.17289654503 | 0.1585019882363272 | |||
| Q8CI59 | Metalloreductase STEAP3 [OS=Mus musculus] | 19.556 | transport;other biological processes | plasma membrane;other membranes;other cytoplasmic organelle | other molecular function | 68428 | Steap3 | mmu:68428; Q3TKE4; Q80ZF3; Q8C5F0; Q8CI59; Q924Z1 | p53 signaling | RHOQ GTPase cycle; RHOF GTPase cycle; RHOD GTPase cycle; Transferrin endocytosis and recycling; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.915790191796374 | 0.654871320915497 | 278199.039870884 | 531695.8311446646 | 1169902.3087042 | 0.9344837139440338 | 1.1377150044392537 | |
| P19253 | Large ribosomal subunit protein uL13 [OS=Mus musculus] | 19.541 | protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes | cytosol;translational apparatus;other cell component | nucleic acid binding activity;other molecular function | 22121 | ENSMUSG00000074129 | Rpl13a | mmu:22121; P19253 | Cytoplasmic ribosomal proteins | L13a-mediated translational silencing of Ceruloplasmin expression; SRP-dependent cotranslational protein targeting to membrane; Major pathway of rRNA processing in the nucleolus and cytosol; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 1.70336894001643E-17 | 1.50457038391225E-17 | 217007.1489289083 | 497419.0235955917 | 1.1967191133460877 | ||
| Q9WVJ2 | 26S proteasome non-ATPase regulatory subunit 13 [OS=Mus musculus] | 19.534 | cell cycle OR cell proliferation;cell organization and biogenesis | other cell component | other molecular function | 23997 | ENSMUSG00000025487 | Psmd13 | mmu:23997; Q3TB19; Q3TR74; Q542R0; Q9WVJ2 | Proteasome degradation | Neddylation; Neutrophil degranulation; AUF1 (hnRNP D0) binds and destabilizes mRNA; ABC-family proteins mediated transport; Hedgehog ligand biogenesis; Ub-specific processing proteases; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Antigen processing: Ubiquitination & Proteasome degradation; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; SCF(Skp2)-mediated degradation of p27/p21; Degradation of beta-catenin by the destruction complex; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; GLI3 is processed to GLI3R by the proteasome; NIK-->noncanonical NF-kB signaling; Orc1 removal from chromatin; Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A; Regulation of RUNX2 expression and activity; Interleukin-1 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Asymmetric localization of PCP proteins; Degradation of AXIN; Hedgehog 'on' state; Regulation of RUNX3 expression and activity; Autodegradation of Cdh1 by Cdh1:APC/C; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; Assembly of the pre-replicative complex; CDK-mediated phosphorylation and removal of Cdc6; The role of GTSE1 in G2/M progression after G2 checkpoint; MAPK6/MAPK4 signaling; UCH proteinases; Regulation of PTEN stability and activity; Regulation of RAS by GAPs; Degradation of CDH1; Regulation of ornithine decarboxylase (ODC); Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); Autodegradation of the E3 ubiquitin ligase COP1; Degradation of DVL; G2/M Checkpoints; Ubiquitin-dependent degradation of Cyclin D; RUNX1 regulates transcription of genes involved in differentiation of HSCs; KEAP1-NFE2L2 pathway; Proteasome assembly; Degradation of CRY and PER proteins | 0.73256524474777 | 0.639608079726835 | 106974.99407844973 | 322781.8966680117 | 954814.5268371053 | 1.5932860677429992 | 1.5646608493408263 |
| P28658 | Ataxin-10 [OS=Mus musculus] | 19.528 | cell organization and biogenesis;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | 54138 | ENSMUSG00000016541 | Atxn10 | mmu:54138; P28658; Q543S3; Q99LP5; Q9D1I1 | 1.70336894001643E-17 | 1.50457038391225E-17 | 86424.4635174749 | 274363.45938786934 | 1.6665767034629462 | |||||
| P62334 | 26S proteasome regulatory subunit 10B [OS=Mus musculus] | 19.508 | other biological processes | cytosol;nucleus;other cell component | other molecular function | 67089 | ENSMUSG00000021832 | Psmc6 | mmu:67089; P49719; P62334; Q3TKK1; Q810A6; Q92524; Q9CXH9 | Proteasome degradation; Comprehensive IL-17A signaling | Degradation of CDH1; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Neddylation; Asymmetric localization of PCP proteins; Degradation of AXIN; Hedgehog 'on' state; Ub-specific processing proteases; Regulation of RUNX3 expression and activity; Antigen processing: Ubiquitination & Proteasome degradation; Autodegradation of Cdh1 by Cdh1:APC/C; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; Assembly of the pre-replicative complex; CDK-mediated phosphorylation and removal of Cdc6; The role of GTSE1 in G2/M progression after G2 checkpoint; MAPK6/MAPK4 signaling; UCH proteinases; Regulation of PTEN stability and activity; ABC-family proteins mediated transport; Regulation of RAS by GAPs; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of ornithine decarboxylase (ODC); Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF(Skp2)-mediated degradation of p27/p21; Degradation of beta-catenin by the destruction complex; Autodegradation of the E3 ubiquitin ligase COP1; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of DVL; Hedgehog ligand biogenesis; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; GLI3 is processed to GLI3R by the proteasome; NIK-->noncanonical NF-kB signaling; Orc1 removal from chromatin; G2/M Checkpoints; Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Proteasome assembly; Degradation of CRY and PER proteins | 0.509695973690503 | 0.610568070666932 | 5338.08208104532 | 38448.0551768281 | 296920.393173676 | 2.8485172296240115 | 2.9490936552250546 |
| P18872 | Guanine nucleotide-binding protein G(o) subunit alpha [OS=Mus musculus] | 19.502 | transport;signal transduction;other biological processes | plasma membrane;other membranes;other cell component | other molecular function | 14681 | ENSMUSG00000031748 | Gnao1 | mmu:14681; P18872; P18873 | G protein signaling pathways; Calcium regulation in cardiac cells | Ca2+ pathway | 0.882045290643365 | 0.679695160937314 | 12280.5087693062 | 639364.4100965793 | 1807564.02187159 | 5.702196202963673 | 1.4993364021458855 |
| Cont_Q3SWW8 | Thrombospondin-4 OS=Bos taurus OX=9913 GN=THBS4 PE=2 SV=1 | 19.497 | cell adhesion;stress response;signal transduction;other biological processes | non-structural extracellular;cytosol;ER/Golgi | signal transduction activity or receptor binding;other molecular function | 541281 | THBS4 | bta:541281; Q3SWW8 | 0.82075531249489 | 0.715318999590614 | 68071.68096387107 | 74884.45760896876 | 100543.37504939927 | 0.13761157992998432 | 0.4250798023175657 | |||
| P97825 | Jupiter microtubule associated homolog 1 [OS=Mus musculus] | 19.496 | cytosol;cytoskeleton;nucleus;other cell component | 15374 | ENSMUSG00000020737 | Jpt1 | mmu:15374; P97825 | 1.50457038391225E-17 | 24843.0885501549 | |||||||||
| P62814 | V-type proton ATPase subunit B, brain isoform [OS=Mus musculus] | 19.492 | cell organization and biogenesis;other metabolic processes;transport | plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component | transporter activity;other molecular function | 11966 | ENSMUSG00000006273 | Atp6v1b2 | mmu:11966; O09045; P50517; P62814; Q3TG74; Q3TL62; Q3TVK6; Q3TWR0; Q3U791; Q3U7C8; Q3U9Z0; Q3UAW7 | Insulin receptor recycling; Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Transferrin endocytosis and recycling; Ion channel transport | 1.70336894001643E-17 | 1.50457038391225E-17 | 54567.7294286105 | 448220.1150283183 | 3.03808747562924 | |||
| Q9R1P3 | Proteasome subunit beta type-2 [OS=Mus musculus] | 19.487 | protein metabolism;other metabolic processes | cytosol;nucleus;other cell component | 26445 | ENSMUSG00000028837 | Psmb2 | mmu:26445; Q9R1P3 | Proteasome degradation | FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Neddylation; Asymmetric localization of PCP proteins; Degradation of AXIN; Hedgehog 'on' state; Ub-specific processing proteases; Regulation of RUNX3 expression and activity; Antigen processing: Ubiquitination & Proteasome degradation; Autodegradation of Cdh1 by Cdh1:APC/C; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; Assembly of the pre-replicative complex; CDK-mediated phosphorylation and removal of Cdc6; The role of GTSE1 in G2/M progression after G2 checkpoint; MAPK6/MAPK4 signaling; UCH proteinases; Regulation of PTEN stability and activity; ABC-family proteins mediated transport; Regulation of RAS by GAPs; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Degradation of CDH1; Regulation of ornithine decarboxylase (ODC); Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF(Skp2)-mediated degradation of p27/p21; Degradation of beta-catenin by the destruction complex; Autodegradation of the E3 ubiquitin ligase COP1; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of DVL; Hedgehog ligand biogenesis; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; GLI3 is processed to GLI3R by the proteasome; NIK-->noncanonical NF-kB signaling; Orc1 removal from chromatin; G2/M Checkpoints; Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Proteasome assembly; Antigen processing: Ub, ATP-independent proteasomal degradation; Degradation of CRY and PER proteins | 1.70336894001643E-17 | 1.50457038391225E-17 | 422351.726197594 | 1074451.28840023 | 1.347083225250838 | |||
| P45591 | Cofilin-2 [OS=Mus musculus] | 19.446 | cell organization and biogenesis;other biological processes | cytoskeleton;nucleus | cytoskeletal activity | 12632 | ENSMUSG00000062929 | Cfl2 | mmu:12632; P45591 | G13 signaling pathway; Regulation of actin cytoskeleton | 1.50457038391225E-17 | 49859.32792014995 | ||||||
| P63158 | High mobility group protein B1 [OS=Mus musculus] | 19.302 | cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | non-structural extracellular;plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component | signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function | 15289 | ENSMUSG00000066551 | Hmgb1 | mmu:15289; P07155; P27109; P27428; P63158 | Comprehensive IL-17A signaling | Neutrophil degranulation; Advanced glycosylation endproduct receptor signaling; Regulation of TLR by endogenous ligand; Pyroptosis; Apoptosis induced DNA fragmentation; TAK1-dependent IKK and NF-kappa-B activation ; TRAF6 mediated NF-kB activation | 1.70336894001643E-17 | 1.50457038391225E-17 | 619474.041379386 | 3440035.67326895 | 2.4733077921619935 | ||
| P97467 | Peptidyl-glycine alpha-amidating monooxygenase [OS=Mus musculus] | 19.291 | other metabolic processes | plasma membrane;other membranes;cytosol;ER/Golgi | other molecular function | 18484 | ENSMUSG00000026335 | Pam | E9QL07; mmu:18484; P97467 | 0.504745711776551 | 0.505642529160643 | 286820.98373783735 | 234559.17798454233 | 413150.15177398664 | -0.2901986223897602 | 0.8167142450979445 | ||
| Q07813 | Apoptosis regulator BAX [OS=Mus musculus] | 19.23 | cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component | transporter activity;other molecular function | 12028 | ENSMUSG00000003873 | Bax | mmu:12028; Q07813 | Apoptosis; IL-5 signaling pathway; BDNF pathway; p53 signaling; IL-7 signaling pathway; IL-3 signaling pathway; Peroxiredoxin 2 induced ovarian failure | Release of apoptotic factors from the mitochondria; Pyroptosis; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Activation, translocation and oligomerization of BAX | 1.70336894001643E-17 | 1.50457038391225E-17 | 110688.29833799035 | 185964.34189778368 | 0.7485233029896802 | ||
| Q11136 | Xaa-Pro dipeptidase [OS=Mus musculus] | 19.227 | protein metabolism;other metabolic processes;other biological processes | other molecular function | 18624 | ENSMUSG00000063931 | Pepd | mmu:18624; P97735; Q11136; Q3TH86; Q9CWK4 | 0.680226731592686 | 0.414879822135619 | 45709.54928359523 | 141326.260593746 | 210992.2368991253 | 1.6284620670053813 | 0.5781603528782097 | |||
| Q03734 | Serine protease inhibitor A3M [OS=Mus musculus] | 19.212 | other biological processes | non-structural extracellular | enzyme regulator activity | 20717 | ENSMUSG00000079012 | Serpina3m | E9Q926; mmu:20717; Q03734; Q62260 | 1.70336894001643E-17 | 1.50457038391225E-17 | 34711.7484291183 | 24863.6410174712 | -0.4813864561740331 | ||||
| Q9DBC7 | cAMP-dependent protein kinase type I-alpha regulatory subunit [OS=Mus musculus] | 19.203 | cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component | enzyme regulator activity;other molecular function | 19084 | ENSMUSG00000020612 | Prkar1a | mmu:19084; Q3UKU7; Q9DBC7; Q9JHR5; Q9JHR6 | G protein signaling pathways; Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells; EGFR1 signaling pathway | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells; Factors involved in megakaryocyte development and platelet production; Hedgehog 'off' state; DARPP-32 events; Vasopressin regulates renal water homeostasis via Aquaporins; PKA activation; PKA activation in glucagon signalling; CREB1 phosphorylation through the activation of Adenylate Cyclase; GPER1 signaling | 0.241757340024399 | 0.419571236523531 | 1212884.7939865876 | 561863.432528681 | 1071245.9393528283 | -1.1101511081135103 | 0.930998321407886 |
| Q9EPC1 | Alpha-parvin [OS=Mus musculus] | 19.19 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | plasma membrane;other membranes;cytoskeleton;nucleus;other cell component | enzyme regulator activity;cytoskeletal activity | 57342 | ENSMUSG00000030770 | Parva | mmu:57342; Q9EPC1; Q9JJ65 | Primary focal segmental glomerulosclerosis (FSGS) | Localization of the PINCH-ILK-PARVIN complex to focal adhesions; Regulation of cytoskeletal remodeling and cell spreading by IPP complex components | 1.50457038391225E-17 | 162045.31415851967 | |||||
| Q01405 | Protein transport protein Sec23A [OS=Mus musculus] | 19.163 | cell organization and biogenesis;transport;other biological processes | other membranes;cytosol;ER/Golgi;other cell component | other molecular function | 20334 | ENSMUSG00000020986 | Sec23a | mmu:20334; Q01405; Q8JZL4 | MHC class II antigen presentation; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; COPII-mediated vesicle transport; Cargo concentration in the ER | 0.119712451380873 | 1.50457038391225E-17 | 3702.616547053075 | 87970.17334737229 | 282361.07038949226 | 4.5703974019380516 | 1.6824548354291808 | |
| O08788 | Dynactin subunit 1 [OS=Mus musculus] | 19.048 | cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes | other membranes;cytosol;cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 13191 | ENSMUSG00000031865 | Dctn1 | E9QLJ1; mmu:13191; O08788; Q3TZG7 | MHC class II antigen presentation; COPI-mediated anterograde transport; Anchoring of the basal body to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; AURKA Activation by TPX2; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-independent Golgi-to-ER retrograde traffic | 0.572894052275701 | 48933.95610166684 | 27158.1695531102 | 302528.21773949265 | -0.8494496772840958 | 3.477611562221175 | ||
| Q9CQW9 | Interferon-induced transmembrane protein 3 [OS=Mus musculus] | 19.029 | stress response;transport;signal transduction;other biological processes | plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component | 66141 | ENSMUSG00000025492 | Ifitm3 | mmu:66141; Q9CQW9; Q9D8L6 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 1.70336894001643E-17 | 1.50457038391225E-17 | 50669.89413613815 | 125764.224881433 | 1.3115208691645708 | ||||
| P61087 | Ubiquitin-conjugating enzyme E2 K [OS=Mus musculus] | 19.001 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes | nucleus;other cell component | other molecular function | 53323 | ENSMUSG00000029203 | Ube2k | mmu:53323; O54806; P27924; P61087; Q16721; Q9CVV9 | Antigen processing: Ubiquitination & Proteasome degradation; Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 1.70336894001643E-17 | 1.50457038391225E-17 | 100957.62246974274 | 342409.77235676866 | 1.7619740360909184 | |||
| Q9CQC6 | eIF5-mimic protein 2 [OS=Mus musculus] | 18.964 | other biological processes | other cell component | 66882 | ENSMUSG00000051223 | Bzw1 | mmu:66882; Q3THS5; Q3UZ94; Q9CQC6 | 1.70336894001643E-17 | 1.50457038391225E-17 | 281477.0118262374 | 959182.0513053095 | 1.768787560084606 | |||||
| Q9CVB6 | Actin-related protein 2/3 complex subunit 2 [OS=Mus musculus] | 18.872 | cell organization and biogenesis;other biological processes | plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component | cytoskeletal activity | 76709 | ENSMUSG00000006304 | Arpc2 | mmu:76709; Q3U870; Q9CVB6 | Comprehensive IL-17A signaling | Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; EPHB-mediated forward signaling; RHO GTPases Activate WASPs and WAVEs | 0.887279041944908 | 0.999577296233586 | 47070.51120920477 | 493011.09168414166 | 1087363.1772941302 | 3.3887246778771294 | 1.141141868731961 |
| O35344 | Importin subunit alpha-4 [OS=Mus musculus] | 18.862 | transport | cytosol;nucleus;other cell component | other molecular function | 16648 | ENSMUSG00000021929 | Kpna3 | mmu:16648; O35344 | 1.70336894001643E-17 | 1.50457038391225E-17 | 45309.089884932066 | 273320.6670897663 | 2.5927221359800448 | ||||
| P23591 | GDP-L-fucose synthase [OS=Mus musculus] | 18.827 | other metabolic processes;other biological processes | cytosol | other molecular function | 22122 | ENSMUSG00000022570 | Gfus | mmu:22122; P23591 | GDP-fucose biosynthesis | 1.70336894001643E-17 | 1.50457038391225E-17 | 48771.26382204866 | 275817.3778477133 | 2.4996100936886823 | |||
| Q9CQM5 | Thioredoxin domain-containing protein 17 [OS=Mus musculus] | 18.82 | signal transduction;other biological processes | cytosol | other molecular function | 52700 | ENSMUSG00000020803 | Txndc17 | mmu:52700; Q3TE14; Q921A9; Q9CQM5; Q9D0Y4 | 1.70336894001643E-17 | 1.50457038391225E-17 | 97085.43286956509 | 519695.59743842174 | 2.420340088766038 | ||||
| Q9CXW3 | Calcyclin-binding protein [OS=Mus musculus] | 18.792 | other biological processes | cytosol;nucleus;other cell component | cytoskeletal activity;other molecular function | 12301 | ENSMUSG00000014226 | Cacybp | mmu:12301; O70140; Q9CXW3 | 0.584481763293876 | 0.239953155149827 | 2064812.331790075 | 2145781.8858667836 | 1785097.827302317 | 0.0554927738302507 | -0.26550029739143716 | ||
| O89079 | Coatomer subunit epsilon [OS=Mus musculus] | 18.787 | transport;other biological processes | other membranes;ER/Golgi;nucleus | other molecular function | 59042 | ENSMUSG00000055681 | Cope | mmu:59042; O89079; Q9JM65 | COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport | 1.70336894001643E-17 | 0.294890363295881 | 55563.6291107796 | 144924.359861946 | ||||
| P63005 | Platelet-activating factor acetylhydrolase IB subunit beta [OS=Mus musculus] | 18.752 | cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes | other membranes;cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 18472 | ENSMUSG00000020745 | Pafah1b1 | mmu:18472; O35592; P43035; P63005; P81692; Q9R2A6 | Wnt signaling; Wnt signaling pathway and pluripotency | Anchoring of the basal body to the plasma membrane; Resolution of Sister Chromatid Cohesion; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; AURKA Activation by TPX2; Separation of Sister Chromatids; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; COPI-independent Golgi-to-ER retrograde traffic | 0.937557038320553 | 0.988826753001082 | 35472.00800992647 | 181663.37877017833 | 668260.6267092143 | 2.356514712092301 | 1.8791432561518393 |
| O08663 | Methionine aminopeptidase 2 [OS=Mus musculus] | 18.752 | protein metabolism;other metabolic processes;other biological processes | plasma membrane;other membranes;cytosol;other cell component | other molecular function | 56307 | ENSMUSG00000036112 | Metap2 | mmu:56307; O08663 | Inactivation, recovery and regulation of the phototransduction cascade | 0.0186303617793598 | 0.533837446822064 | 56247.344437666434 | 17177.62978308649 | 270391.29099150206 | -1.7112540019400837 | 3.9764457964692275 | |
| P97461 | Small ribosomal subunit protein uS7 [OS=Mus musculus] | 18.645 | protein metabolism;other metabolic processes;other biological processes | cytosol;translational apparatus;nucleus;other cell component | nucleic acid binding activity;other molecular function | 20103 | ENSMUSG00000012848 | Rps5 | mmu:20103; O08607; P97461; Q91V55 | Cytoplasmic ribosomal proteins | L13a-mediated translational silencing of Ceruloplasmin expression; SRP-dependent cotranslational protein targeting to membrane; Major pathway of rRNA processing in the nucleolus and cytosol; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition | 1.70336894001643E-17 | 1.50457038391225E-17 | 312317.33157336403 | 622594.0885478373 | 0.9952792469270189 | ||
| Q9D1G1 | Ras-related protein Rab-1B [OS=Mus musculus] | 18.61 | cell organization and biogenesis;other metabolic processes;transport;other biological processes | other membranes;ER/Golgi;other cell component | other molecular function | 76308 | ENSMUSG00000024870 | Rab1b | mmu:76308; Q3U0N1; Q9D1G1 | COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport; RAB geranylgeranylation; Golgi Cisternae Pericentriolar Stack Reorganization | 1.70336894001643E-17 | 1.50457038391225E-17 | 12732.47121683503 | 40663.34631197424 | 1.675216488018295 | |||
| Q9D662 | Protein transport protein Sec23B [OS=Mus musculus] | 18.607 | cell organization and biogenesis;transport | other membranes;cytosol;ER/Golgi;other cell component | other molecular function | 27054 | ENSMUSG00000027429 | Sec23b | A2ANA1; mmu:27054; Q3U6B3; Q99K49; Q9D662; Q9QZ68 | 1.50457038391225E-17 | 38810.64092277493 | |||||||
| Q8BFS6 | Serine/threonine-protein phosphatase CPPED1 [OS=Mus musculus] | 18.536 | plasma membrane;other membranes;cytosol | other molecular function | 223978 | ENSMUSG00000065979 | Cpped1 | mmu:223978; Q3UYF7; Q8BFS6; Q8BJQ3; Q8BYB7; Q8K236; Q8R3G2 | Neutrophil degranulation | 0.725011767157745 | 10288.2626930526 | 209164.98229362068 | 530202.4887928537 | 4.345570050498096 | 1.3419021017020392 | |||
| Q9JK81 | MYG1 exonuclease [OS=Mus musculus] | 18.463 | RNA metabolism OR transcription;other metabolic processes;other biological processes | mitochondrion;nucleus | other molecular function | 60315 | ENSMUSG00000001285 | Myg1 | mmu:60315; Q9CYX0; Q9JK81 | 0.0461213267204912 | 0.331752954130166 | 54740.7745598674 | 70367.02536567296 | 456112.6176951903 | 0.3622836786715656 | 2.6964186486331467 | ||
| P49817 | Caveolin-1 [OS=Mus musculus] | 18.438 | cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component | signal transduction activity or receptor binding;enzyme regulator activity;other molecular function | 12389 | ENSMUSG00000007655 | Cav1 | mmu:12389; P49817; Q8C1X7; Q8CBP4; Q9QYH3; Q9QYH4 | Na/K-ATPase/Src signaling; EGFR1 signaling pathway; Integrin-mediated cell adhesion; Focal adhesion | RHOF GTPase cycle; RHOD GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHOC GTPase cycle; RHOG GTPase cycle; RND2 GTPase cycle; RHOH GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; Extra-nuclear estrogen signaling; RND3 GTPase cycle; RND1 GTPase cycle; Basigin interactions; Disassembly of the destruction complex and recruitment of AXIN to the membrane; VEGFR2 mediated vascular permeability; eNOS activation; NOSTRIN mediated eNOS trafficking | 1.70336894001643E-17 | 1.50457038391225E-17 | 13061.2168146306 | 672872.5483721506 | 1081592.5640088029 | 5.686972050532535 | 0.684751969310285 |
| Q6NSR8 | Probable aminopeptidase NPEPL1 [OS=Mus musculus] | 18.405 | protein metabolism | other cell component | other molecular function | 228961 | ENSMUSG00000039263 | Npepl1 | A2ACM6; mmu:228961; Q66JY0; Q6NSR8 | 1.70336894001643E-17 | 1.50457038391225E-17 | 104728.99789703103 | 310810.16458017234 | 1.5693727273801288 | ||||
| Q3UM45 | Protein phosphatase 1 regulatory subunit 7 [OS=Mus musculus] | 18.342 | cell cycle OR cell proliferation | nucleus;other cell component | enzyme regulator activity | 66385 | ENSMUSG00000026275 | Ppp1r7 | mmu:66385; Q3UM45; Q9CV31; Q9Z105 | 0.79403579468947 | 0.72337684182927 | 18573.517658339733 | 92620.05182658427 | 315219.63661465 | 2.318077489613236 | 1.7669609408845086 | ||
| Q6PGH2 | Jupiter microtubule associated homolog 2 [OS=Mus musculus] | 18.34 | nucleus;other cell component | 52009 | ENSMUSG00000024165 | Jpt2 | mmu:52009; Q6PGH2 | 1.70336894001643E-17 | 1.50457038391225E-17 | 53062.43899623813 | 178651.46059215566 | 1.751384813773337 | ||||||
| Q9R1P0 | Proteasome subunit alpha type-4 [OS=Mus musculus] | 18.333 | protein metabolism;other metabolic processes | cytosol;nucleus;other cell component | 26441 | ENSMUSG00000032301 | Psma4 | mmu:26441; Q3THT1; Q9R1P0 | Proteasome degradation; Exercise-induced circadian regulation | RUNX1 regulates transcription of genes involved in differentiation of HSCs; Ub-specific processing proteases; UCH proteinases; Neddylation; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); Proteasome assembly; Antigen processing: Ub, ATP-independent proteasomal degradation; Degradation of CDH1; ABC-family proteins mediated transport; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Hedgehog 'on' state; Regulation of RAS by GAPs; Degradation of DVL; KEAP1-NFE2L2 pathway; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Asymmetric localization of PCP proteins; Degradation of AXIN; Regulation of RUNX3 expression and activity; Autodegradation of Cdh1 by Cdh1:APC/C; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Assembly of the pre-replicative complex; CDK-mediated phosphorylation and removal of Cdc6; MAPK6/MAPK4 signaling; Regulation of PTEN stability and activity; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of ornithine decarboxylase (ODC); SCF(Skp2)-mediated degradation of p27/p21; Degradation of beta-catenin by the destruction complex; Autodegradation of the E3 ubiquitin ligase COP1; AUF1 (hnRNP D0) binds and destabilizes mRNA; Hedgehog ligand biogenesis; Degradation of GLI1 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Orc1 removal from chromatin; G2/M Checkpoints; Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; Regulation of RUNX2 expression and activity; Interleukin-1 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Degradation of CRY and PER proteins | 1.70336894001643E-17 | 1.50457038391225E-17 | 32608.398323872316 | 334376.459118635 | 1101131.00215331 | 3.358157797003411 | 1.71944093030931 | |
| O55135 | Eukaryotic translation initiation factor 6 [OS=Mus musculus] | 18.307 | cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes | cytoskeleton;nucleus;other cell component | translation activity;other molecular function | 16418 | ENSMUSG00000027613 | Eif6 | mmu:16418; O55135 | Translation factors; Alpha 6 beta 4 integrin signaling pathway | 1.70336894001643E-17 | 1.50457038391225E-17 | 156469.297489735 | 826307.5666640056 | 2.400799280530046 | |||
| Q8CCS6 | Polyadenylate-binding protein 2 [OS=Mus musculus] | 18.304 | RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes | cytosol;nucleus;other cell component | nucleic acid binding activity;other molecular function | 54196 | ENSMUSG00000022194 | Pabpn1 | mmu:54196; O35935; Q8CCS6 | mRNA processing | mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Nuclear RNA decay; Processing of Intronless Pre-mRNAs | 1.50457038391225E-17 | 68907.9695817164 | |||||
| P62821 | Ras-related protein Rab-1A [OS=Mus musculus] | 18.288 | cell adhesion;cell-cell signaling;cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes | other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component | other molecular function | 19324 | ENSMUSG00000020149 | Rab1a | mmu:19324; P11476; P62821; Q3TX44; Q811M4; Q96N61; Q9Y3T2 | COPII-mediated vesicle transport; COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; Golgi Cisternae Pericentriolar Stack Reorganization | 0.811642495923494 | 0.975483104913309 | 54354.01041599363 | 556719.0914155614 | 1562338.9563713865 | 3.3564911669652306 | 1.4886860234197115 | |
| O70589 | Peripheral plasma membrane protein CASK [OS=Mus musculus] | 18.258 | transport;other biological processes | extracellular matrix;plasma membrane;other membranes;cytosol;nucleus;other cell component | signal transduction activity or receptor binding;kinase activity;other molecular function | 12361 | ENSMUSG00000031012 | Cask | A2ADP8; A2ADP9; A2ADQ4; mmu:12361; O70588; O70589; Q3UW92 | Splicing factor NOVA regulated synaptic proteins | Dopamine Neurotransmitter Release Cycle; Neurexins and neuroligins | 1.70336894001643E-17 | 1.50457038391225E-17 | 33261.86473120025 | 432180.540657786 | 3.6996931583643105 | ||
| Q62167 | ATP-dependent RNA helicase DDX3X [OS=Mus musculus] | 18.217 | cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component | enzyme regulator activity;cytoskeletal activity;translation activity;nucleic acid binding activity;other molecular function | 13205 | ENSMUSG00000000787 | Ddx3x | mmu:13205; O09060; O09143; Q62167 | mRNA processing | Neutrophil degranulation | 1.70336894001643E-17 | 1.50457038391225E-17 | 45248.1340379442 | 260348.63756564003 | 2.5245146529036586 | ||
| P61222 | ATP-binding cassette sub-family E member 1 [OS=Mus musculus] | 18.113 | cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes | cytosol;mitochondrion;translational apparatus;other cell component | enzyme regulator activity;other molecular function | 24015 | ENSMUSG00000058355 | Abce1 | mmu:24015; O88793; P61222; Q13181; Q13864; Q96AL0; Q96B10; Q99K66 | Interferon alpha/beta signaling; OAS antiviral response | 1.50457038391225E-17 | 140573.6944797896 | ||||||
| Q9Z204 | Heterogeneous nuclear ribonucleoproteins C1/C2 [OS=Mus musculus] | 18.109 | RNA metabolism OR transcription;other metabolic processes | cytoskeleton;nucleus;other cell component | nucleic acid binding activity;other molecular function | 15381 | ENSMUSG00000060373 | Hnrnpc | mmu:15381; Q3TLB5; Q501Q3; Q8C2G5; Q99KE2; Q9CQT3; Q9CY83; Q9Z204 | mRNA processing | Processing of Capped Intron-Containing Pre-mRNA; mRNA Splicing - Major Pathway; SUMOylation of RNA binding proteins; RHOBTB1 GTPase cycle; RHOBTB2 GTPase cycle | 1.70336894001643E-17 | 1.50457038391225E-17 | 133491.03728948988 | 730412.5423538358 | 2.4519686576225865 | ||
| Q9CPR4 | Large ribosomal subunit protein uL22 [OS=Mus musculus] | 18.043 | protein metabolism;other metabolic processes;stress response;other biological processes | cytosol;cytoskeleton;translational apparatus;other cell component | nucleic acid binding activity;other molecular function | 319195 | ENSMUSG00000062328 | Rpl17 | mmu:319195; Q6ZWZ7; Q9CPR4 | Cytoplasmic ribosomal proteins | L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; SRP-dependent cotranslational protein targeting to membrane; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 1.70336894001643E-17 | 1.50457038391225E-17 | 3320.54369764616 | 296490.53048539866 | 805741.731097314 | 6.480422733268143 | 1.4423314500025106 |
| Q9JIW9 | Ras-related protein Ral-B [OS=Mus musculus] | 17.96 | stress response;transport;signal transduction;other biological processes | plasma membrane;other membranes;other cell component | other molecular function | 64143 | ENSMUSG00000004451 | Ralb | mmu:64143; Q3TVS5; Q9JIW9 | EGFR1 signaling pathway | 1.70336894001643E-17 | 1.50457038391225E-17 | 40207.244281434905 | 142293.30007679132 | 1.8233403683244118 | |||
| P17439 | Lysosomal acid glucosylceramidase [OS=Mus musculus] | 17.857 | cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes | non-structural extracellular;other membranes;ER/Golgi;other cytoplasmic organelle | signal transduction activity or receptor binding;other molecular function | 14466 | ENSMUSG00000028048 | Gba1 | mmu:14466; P17439; Q78NR7 | Glycosphingolipid catabolism | 1.70336894001643E-17 | 1.50457038391225E-17 | 26243.22793207875 | 126053.08382236019 | 2.2640143251032434 | |||
| Q9CQI3 | Glia maturation factor beta [OS=Mus musculus] | 17.826 | signal transduction;other biological processes | signal transduction activity or receptor binding;cytoskeletal activity;other molecular function | 63985 | ENSMUSG00000062014 | Gmfb | mmu:63985; Q3UQX5; Q9CQI3; Q9ERL8 | 0.962339884242628 | 63706.35827791835 | 18785.40810950407 | 425763.11582554335 | -1.7618249107121773 | 4.502366609747538 | ||||
| Q60668 | Heterogeneous nuclear ribonucleoprotein D0 [OS=Mus musculus] | 17.818 | developmental processes;other biological processes | cytosol;nucleus;other cell component | nucleic acid binding activity;other molecular function | 11991 | ENSMUSG00000000568 | Hnrnpd | mmu:11991; Q60667; Q60668; Q80ZJ0; Q91X94 | mRNA processing | mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA; AUF1 (hnRNP D0) binds and destabilizes mRNA | 1.70336894001643E-17 | 1.50457038391225E-17 | 230798.48743516966 | 1355884.1301271934 | 2.5545282210071427 | ||
| Q80T21 | ADAMTS-like protein 4 [OS=Mus musculus] | 17.608 | cell organization and biogenesis;other biological processes | non-structural extracellular;extracellular matrix | other molecular function | 229595 | ENSMUSG00000015850 | Adamtsl4 | mmu:229595; Q148X6; Q80T21 | O-glycosylation of TSR domain-containing proteins | 0.850600578281519 | 15836.4532151337 | 85794.85270476116 | 202148.60935214968 | 2.437641834473618 | 1.2364532784732922 | ||
| Q9Z0X1 | Apoptosis-inducing factor 1, mitochondrial [OS=Mus musculus] | 17.525 | cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes | other membranes;cytosol;mitochondrion;nucleus;other cell component | nucleic acid binding activity;other molecular function | 26926 | ENSMUSG00000036932 | Aifm1 | mmu:26926; Q1L6K5; Q9Z0X1 | Apoptosis modulation by HSP70 | 1.70336894001643E-17 | 1.50457038391225E-17 | 37175.0361049444 | 164033.99044641366 | 2.141588746574735 | |||
| Q9WTQ5 | A-kinase anchor protein 12 [OS=Mus musculus] | 17.484 | signal transduction;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | other molecular function | 83397 | ENSMUSG00000038587 | Akap12 | mmu:83397; Q80SS4; Q810D4; Q8BPK4; Q99MP1; Q9WTQ5 | G protein signaling pathways | RHOF GTPase cycle; RHOD GTPase cycle | 1.50457038391225E-17 | 28573.293424856653 | |||||
| P43276 | Histone H1.5 [OS=Mus musculus] | 17.427 | cell organization and biogenesis;other biological processes | nucleus;other cell component | nucleic acid binding activity;other molecular function | 56702 | ENSMUSG00000058773 | H1-5 | mmu:56702; P43276; Q9CRM8 | Formation of Senescence-Associated Heterochromatin Foci (SAHF); Apoptosis induced DNA fragmentation | 1.70336894001643E-17 | 1.50457038391225E-17 | 746570.4175421327 | 1433708.113792333 | 0.9414010892350235 | |||
| Q80XU3 | Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 [OS=Mus musculus] | 17.418 | cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes | nucleus;other cell component | nucleic acid binding activity;other molecular function | 98415 | ENSMUSG00000026434 | Nucks1 | mmu:98415; Q80XU3; Q8BVD8 | 0.524409205544216 | 1.50457038391225E-17 | 45141.959652123835 | 273010.99401375366 | 970702.7546788864 | 2.596418095248936 | 1.8300705371547321 | ||
| Cont_P42916 | Collectin-43 OS=Bos taurus OX=9913 GN=CL43 PE=1 SV=2 | 17.396 | other biological processes | non-structural extracellular;other cytoplasmic organelle;other cell component | other molecular function | 431784 | CL43 | bta:431784; P42916; Q1LZ84; Q8WMF4 | 0.56859571311815 | 0.731313507536435 | 344025.40005881066 | 252892.82125531867 | 483292.196790823 | -0.44398900131242247 | 0.9343696167743304 | |||
| Q9CZU6 | Citrate synthase, mitochondrial [OS=Mus musculus] | 17.355 | other metabolic processes | mitochondrion | other molecular function | 12974 | ENSMUSG00000005683 | Cs | mmu:12974; Q3UDP3; Q9CZU6 | TCA cycle | Mitochondrial protein degradation; Citric acid cycle (TCA cycle) | 0.753448703421541 | 0.52060250606116 | 322929.933212051 | 544880.1150702246 | 738312.9439990466 | 0.7547176676734646 | 0.43829360990208427 |
| Q9CWK8 | Sorting nexin-2 [OS=Mus musculus] | 17.345 | cell organization and biogenesis;transport | other membranes;cytosol;other cytoplasmic organelle;other cell component | signal transduction activity or receptor binding;other molecular function | 67804 | ENSMUSG00000034484 | Snx2 | mmu:67804; Q3UKW3; Q9CQV0; Q9CWK8 | Golgi Associated Vesicle Biogenesis | 1.70336894001643E-17 | 1.50457038391225E-17 | 82452.69281182277 | 364723.5594301147 | 2.145164877676989 | |||
| P63028 | Translationally-controlled tumor protein [OS=Mus musculus] | 17.34 | other biological processes | cytosol;cytoskeleton;nucleus;other cytoplasmic organelle | other molecular function | 22070 | ENSMUSG00000060126 | Tpt1 | mmu:22070; P14701; P63028; Q3TMT0; Q3TWS8; Q3TWX0; Q3UAG7; Q569M9 | 1.70336894001643E-17 | 1.50457038391225E-17 | 79626.02027086644 | 553428.741559864 | 2.797085712012185 | ||||
| O35841 | Apoptosis inhibitor 5 [OS=Mus musculus] | 17.293 | other biological processes | nucleus;other cell component | other molecular function | 11800 | ENSMUSG00000027193 | Api5 | mmu:11800; O35841; Q3U517; Q922L2 | 1.70336894001643E-17 | 1.50457038391225E-17 | 168906.52641184864 | 903921.4350092676 | 2.4199723114096465 | ||||
| O35658 | Complement component 1 Q subcomponent-binding protein, mitochondrial [OS=Mus musculus] | 17.284 | cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes | non-structural extracellular;plasma membrane;other membranes;mitochondrion;nucleus;other cell component | signal transduction activity or receptor binding;enzyme regulator activity;translation activity;nucleic acid binding activity;other molecular function | C1qbp | O35658 | RHOA GTPase cycle; RHOC GTPase cycle; Intrinsic Pathway of Fibrin Clot Formation | 0.971489814526882 | 0.619345403494574 | 16688.4245986709 | 147966.35763408663 | 425275.1696414977 | 3.1483495202143508 | 1.5231274285783245 |
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| Accession | Description | Sum PEP Score | Biological Process | Cellular Component | Molecular Function | Entrez Gene ID | Ensembl Gene ID | Gene Symbol | Gene ID | WikiPathways | Reactome Pathways | Abundance Ratio Adj. P-Value: (SQ_16h) / (LQ_16h) | Abundance Ratio Adj. P-Value: (SQ_6h) / (LQ_6h) | LQ6h_AVERAGE | LQ16h_AVERAGE | LQ24h_AVERAGE | SQ6h_AVERAGE | SQ16h_AVERAGE | FC_SQ_16_vs_LQ_16h | FC_SQ_6_vs_LQ_6h |
| P11276 | Fibronectin [OS=Mus musculus] | 867.353 | cell adhesion;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi | signal transduction activity or receptor binding;enzyme regulator activity;other molecular function | 14268 | ENSMUSG00000026193 | Fn1 | G5E8B8; mmu:14268; P11276; Q61567; Q61568; Q61569; Q64233; Q80UI4 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Inflammatory response pathway; Regulation of actin cytoskeleton; Comprehensive IL-17A signaling; Focal adhesion | ECM proteoglycans; Platelet degranulation ; Cell surface interactions at the vascular wall; Syndecan interactions; MAP2K and MAPK activation; Integrin cell surface interactions; Molecules associated with elastic fibres; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Fibronectin matrix formation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; Degradation of the extracellular matrix; Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells; MET activates PTK2 signaling; GPER1 signaling | 0.974036928885484 | 0.435823028559966 | 2.022341523870097E8 | 2.12696235413058E8 | 2.684744239015217E8 | 1.2629719382404166E8 | 2.7495824150743634E8 | 0.37041803136358886 | -0.6792040691298411 |
| P11087 | Collagen alpha-1(I) chain [OS=Mus musculus] | 797.017 | cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12842 | ENSMUSG00000001506 | Col1a1 | mmu:12842; P11087; Q53WT0; Q60635; Q61367; Q61427; Q63919; Q6PCL3; Q810J9 | Osteoblast signaling; Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Comprehensive IL-17A signaling; Focal adhesion | Cell surface interactions at the vascular wall; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ECM proteoglycans; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; GPVI-mediated activation cascade; GP1b-IX-V activation signalling; Platelet Adhesion to exposed collagen; Platelet Aggregation (Plug Formation); MET activates PTK2 signaling | 1.58880673198775E-4 | 0.0629214061377862 | 2.0798706453114033E8 | 5.92854376184685E8 | 5.928171930552336E8 | 5.973622733379293E7 | 8.428319253806247E7 | -2.814360908962058 | -1.799815773091645 |
| Q01149 | Collagen alpha-2(I) chain [OS=Mus musculus] | 773.662 | cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12843 | ENSMUSG00000029661 | Col1a2 | mmu:12843; Q01149; Q8CGA5 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Focal adhesion | Crosslinking of collagen fibrils; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; ECM proteoglycans; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; GPVI-mediated activation cascade; GP1b-IX-V activation signalling; Platelet Adhesion to exposed collagen; Platelet Aggregation (Plug Formation); MET activates PTK2 signaling | 0.0150838661305169 | 0.0347692006632991 | 1.7308392932505235E8 | 3.475967473053053E8 | 4.108532345040607E8 | 4.271481968913147E7 | 9.036410240893161E7 | -1.9435929082069783 | -2.018663180583724 |
| P08121 | Collagen alpha-1(III) chain [OS=Mus musculus] | 695.631 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | extracellular matrix;other cell component | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 12825 | ENSMUSG00000026043 | Col3a1 | mmu:12825; P08121; Q61429; Q9CRN7 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Focal adhesion | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ECM proteoglycans; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; MET activates PTK2 signaling | 0.00738207855214502 | 0.394949139624895 | 6.282890624937943E7 | 2.8394661715058166E8 | 2.9634851273536664E8 | 3.0365458724261332E7 | 6.6157215803336866E7 | -2.101649298329015 | -1.0489973014656733 |
| Q9QXS1 | Plectin [OS=Mus musculus] | 659.702 | cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component | cytoskeletal activity;other molecular function | 18810 | ENSMUSG00000022565 | Plec | E9QN87; mmu:18810; Q6S384; Q6S389; Q6S394; Q9CS65; Q9QUT2; Q9QXQ8; Q9QXQ9; Q9QXR0; Q9QXR1; Q9QXR2; Q9QXR3; Q9QXR4; Q9QXR5; Q9QXR6; Q9QXR7; Q9QXR8; Q9QXR9; Q9QXS0; Q9QXS1; Q9QXS2; Q9QXS3 | Alpha 6 beta 4 integrin signaling pathway; EGFR1 signaling pathway | Type I hemidesmosome assembly; Caspase-mediated cleavage of cytoskeletal proteins | 0.850917681937748 | 0.702330308974487 | 4599273.114185064 | 1.6676006673579365E7 | 4.0231485359460294E7 | 1.01501282886872E7 | 4.28490141732006E7 | 1.3614881580387048 | 1.1420201863832355 |
| P08122 | Collagen alpha-2(IV) chain [OS=Mus musculus] | 526.992 | RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix | extracellular structural activity | 12827 | ENSMUSG00000031503 | Col4a2 | mmu:12827; P08122; Q3B7C2; Q3TPV9; Q61375; Q66JS5; Q6RCT6; Q6RCT7; Q6U9X1; Q8BPI9; Q8BPK3; Q91VI3 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Focal adhesion | Laminin interactions; Signaling by PDGF; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions | 0.979628232635575 | 0.959159975702413 | 1.3981747232493034E7 | 5.0194805286054574E7 | 9.68446240720073E7 | 1.701609057115766E7 | 5.972856146483746E7 | 0.25088290969327387 | 0.2833549587108298 |
| Q3U962 | Collagen alpha-2(V) chain [OS=Mus musculus] | 518.514 | cell organization and biogenesis;developmental processes;other biological processes | extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12832 | ENSMUSG00000026042 | Col5a2 | mmu:12832; Q3TVR2; Q3U962; Q3UHK7; Q3UTT4; Q3V1J6; Q61431; Q7TMS0; Q80VS8 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions | 0.0769666553885184 | 0.453486790198347 | 1.5753424919239333E7 | 4.592471970087584E7 | 6.332560400994137E7 | 1.0471363011153279E7 | 2.1079551940947264E7 | -1.1234267140336414 | -0.5892162722872147 |
| Q05793 | Basement membrane-specific heparan sulfate proteoglycan core protein [OS=Mus musculus] | 507.28 | cell organization and biogenesis;transport;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;ER/Golgi | other molecular function | 15530 | Hspg2 | mmu:15530; Q05793 | 0.208890689478245 | 0.285967432697218 | 2.1355561683383033E7 | 4.109385814368304E7 | 4.603208822128189E7 | 8244737.341084313 | 1.8998181152407136E7 | -1.1130614814811859 | -1.373066405061947 | |||
| Q61554 | Fibrillin-1 [OS=Mus musculus] | 499.202 | cell adhesion;other metabolic processes;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 14118 | ENSMUSG00000027204 | Fbn1 | A2AQ53; mmu:14118; Q60826; Q61554 | Comprehensive IL-17A signaling | Integrin cell surface interactions; Degradation of the extracellular matrix; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; TGF-beta receptor signaling activates SMADs; Molecules associated with elastic fibres | 0.087482121441914 | 0.0455630470425967 | 2.17735814942991E7 | 5.216417896597137E7 | 4.48746709774994E7 | 5145074.9913376765 | 2.082557122129057E7 | -1.3247033834999922 | -2.0813147229720497 |
| Q8BTM8 | Filamin-A [OS=Mus musculus] | 493.069 | cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;other molecular function | 192176 | ENSMUSG00000031328 | Flna | B7FAV0; O54934; Q7TQI1; Q8BLK1; Q8BTM8; Q8BTN7; Q8VHX5; Q8VHX8; Q99KQ2 | Mapk signaling pathway; Focal adhesion | Platelet degranulation ; Cell-extracellular matrix interactions; RHO GTPases activate PAKs; GP1b-IX-V activation signalling | 0.946239447314336 | 0.904360680536565 | 4952287.405198824 | 1.1395384793048913E7 | 3.45895898091015E7 | 4296604.098486893 | 1.4686023116833666E7 | 0.36599413443703693 | -0.20489819440782575 |
| P02463 | Collagen alpha-1(IV) chain [OS=Mus musculus] | 487.707 | cell organization and biogenesis;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix | extracellular structural activity;other molecular function | 12826 | ENSMUSG00000031502 | Col4a1 | mmu:12826; P02463; Q3UHJ4; Q3UJE7; Q3UQV2; Q53X35; Q6GQS7; Q6PHB5; Q99LQ8 | Spinal cord injury; Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Laminin interactions; Signaling by PDGF; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions | 0.483508479481234 | 0.777395712279767 | 4620515.057112186 | 2.1463797748519864E7 | 4.45598479783772E7 | 8911949.32392111 | 3.3156314746725336E7 | 0.627378297898211 | 0.9476873486816851 |
| Q60847 | Collagen alpha-1(XII) chain [OS=Mus musculus] | 480.266 | cell adhesion;developmental processes | other cell component | 12816 | ENSMUSG00000032332 | Col12a1 | mmu:12816; P70322; Q60847 | Assembly of collagen fibrils and other multimeric structures; Collagen chain trimerization; Collagen degradation | 0.119424004207039 | 0.0103905836841461 | 5.1736330625803865E7 | 2.9952489655588504E7 | 5.41828161343536E7 | 1.0537780206453351E7 | 1.4629541968462234E7 | -1.033791323716814 | -2.2956067413237813 | ||
| Q8VDD5 | Myosin-9 [OS=Mus musculus] | 418.364 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;stress response;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;other molecular function | 17886 | ENSMUSG00000022443 | Myh9 | mmu:17886; Q3UHT9; Q3UHU4; Q6KAN6; Q811I2; Q8VDD5 | Primary focal segmental glomerulosclerosis (FSGS) | RHO GTPases activate PAKs; Regulation of actin dynamics for phagocytic cup formation | 0.87421335771164 | 0.91728043005175 | 5176534.940650649 | 8067345.413832072 | 1.95000780331961E7 | 7844465.70271172 | 1.9759662960152034E7 | 1.2923924059140754 | 0.5996884741558165 |
| Cont_P02453 | Collagen alpha-1(I) chain OS=Bos taurus OX=9913 GN=COL1A1 PE=1 SV=3 | 414.689 | cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | 282187 | ENSBTAG00000013103 | COL1A1 | bta:282187; P02453; Q3MHM2 | Inflammatory response pathway; Osteoblast signaling; Focal adhesion | Fibronectin matrix formation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Collagen degradation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; Collagen chain trimerization; GPVI-mediated activation cascade; Platelet Aggregation (Plug Formation); Platelet Adhesion to exposed collagen; GP1b-IX-V activation signalling | 0.067749585016969 | 0.108042253370914 | 3262486.7198886867 | 3910059.36528234 | 2611857.205675677 | 1102058.9569362423 | 924822.5329095138 | -2.079942057680374 | -1.5657706231882562 |
| Cont_P02769 | Albumin OS=Bos taurus OX=9913 GN=ALB PE=1 SV=4 | 390.555 | stress response;other biological processes | non-structural extracellular;other cell component | nucleic acid binding activity;other molecular function | 280717 | ALB | A5PJX3; bta:280717; O02787; P02769; P04277; Q3SZR2 | 0.946568086066385 | 0.846117085258013 | 2.9099571807541137E9 | 2.4034772237737E9 | 1.9319093626168566E9 | 2.38097622607819E9 | 2.6841204207378564E9 | 0.15932626621701673 | -0.28944470896955565 | |||
| P01027 | Complement C3 [OS=Mus musculus] | 388.541 | cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular;other cell component | signal transduction activity or receptor binding;enzyme regulator activity | 12266 | ENSMUSG00000024164 | C3 | mmu:12266; P01027; Q61370; Q80XP1 | Complement activation, classical pathway; Tyrobp causal network in microglia; Comprehensive IL-17A signaling | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade; Neutrophil degranulation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; G alpha (i) signalling events; Peptide ligand-binding receptors; Alternative complement activation; Activation of C3 and C5 | 0.939492000987438 | 0.413470300505934 | 1.6657146132333001E7 | 4.4549110086954266E7 | 9.444511683907779E7 | 3.6733221642207734E7 | 8.026680998659676E7 | 0.8494069495035886 | 1.1409441863835255 |
| Cont_Q7SIH1 | Alpha-2-macroglobulin OS=Bos taurus OX=9913 GN=A2M PE=1 SV=2 | 370.864 | non-structural extracellular | enzyme regulator activity;other molecular function | 513856 | ENSBTAG00000018137 | A2M | A8E647; bta:513856; Q7SIH1 | IL-6 signaling pathway | 0.944154202827561 | 0.671798309985569 | 7.564994624258716E7 | 7.018676700369896E7 | 1.6376415758098435E8 | 5.23492843648457E7 | 8.250822323914327E7 | 0.23333886293366002 | -0.5311692421661273 | ||
| Cont_Q29443 | Serotransferrin OS=Bos taurus OX=9913 GN=TF PE=2 SV=1 | 343.183 | stress response;transport;other biological processes | non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle | other molecular function | 280705 | TF | bta:280705; Q0IIK2; Q29443 | 0.902231721267411 | 0.506704636011438 | 2.32106703986673E8 | 1.5606409762411097E8 | 1.0552713551758902E8 | 1.3567523181654152E8 | 1.6257112433260167E8 | 0.058932345527944796 | -0.7746308192572785 | |||
| Cont_P07589 | Fibronectin OS=Bos taurus OX=9913 GN=FN1 PE=1 SV=4 | 337.517 | cell adhesion;cell organization and biogenesis;stress response;developmental processes;other biological processes | non-structural extracellular | signal transduction activity or receptor binding;other molecular function | FN1 | P07589 | 0.553450172742796 | 0.35834247597224 | 835883.8306505851 | 952169.9232567847 | 590914.7645248 | 482619.7682389803 | 602598.7403397557 | -0.6600214012146457 | -0.7924154436110592 | ||||
| Q80X90 | Filamin-B [OS=Mus musculus] | 335.882 | cell organization and biogenesis;stress response;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 286940 | ENSMUSG00000025278 | Flnb | E9QNV9; mmu:286940; Q80X90; Q8VHX4; Q8VHX7; Q99KY3 | ISG15 antiviral mechanism | 0.936411452199724 | 0.872448101434609 | 2351112.5534752235 | 6048828.490809467 | 1.7547066707595836E7 | 1865154.4144755967 | 7592568.170254476 | 0.3279322018375229 | -0.3340485310994022 | |
| Cont_P35527 | Keratin, type I cytoskeletal 9 OS=Homo sapiens OX=9606 GN=KRT9 PE=1 SV=3 | 310.424 | cell organization and biogenesis;other biological processes | cytosol;cytoskeleton | cytoskeletal activity | 3857 | ENSG00000171403 | KRT9 | hsa:3857; O00109; P35527; Q0IJ47; Q14665 | Formation of the cornified envelope | 0.873609880131656 | 0.516448827835279 | 3.250630567014273E7 | 4.1318104811136335E7 | 3.4478974092312835E7 | 9.369998400542612E7 | 5.1433611479478456E7 | 0.31593737616513196 | 1.5273291980404673 | |
| Cont_P04264 | Keratin, type II cytoskeletal 1 OS=Homo sapiens OX=9606 GN=KRT1 PE=1 SV=6 | 306.58 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;other molecular function | 3848 | ENSG00000167768 | KRT1 | B2RA01; hsa:3848; P04264; P85925; P86104; Q14720; Q6GSJ0; Q9H298 | Corticotropin-releasing hormone signaling | Formation of the cornified envelope; Neutrophil degranulation; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.873609880131656 | 0.254077056479593 | 1.3414412508194733E8 | 1.6528138436319932E8 | 1.1322276749996448E8 | 4.476405570139613E8 | 1.7631437693719265E8 | 0.09322587587347089 | 1.738556880584629 |
| P06909 | Complement factor H [OS=Mus musculus] | 292.01 | cell adhesion;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes | non-structural extracellular;plasma membrane;other membranes;mitochondrion;other cell component | other molecular function | 12628 | ENSMUSG00000026365 | Cfh | mmu:12628; P06909; Q6NZK3 | Regulation of Complement cascade | 0.678323397545056 | 0.750662231008662 | 1.0566840244224759E7 | 1.036081717107911E7 | 1.3701110968154365E7 | 8439848.284125684 | 2.9357524779450033E7 | 1.502592540643395 | -0.3242550682599269 | |
| P16546 | Spectrin alpha chain, non-erythrocytic 1 [OS=Mus musculus] | 291.854 | cell organization and biogenesis | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 20740 | ENSMUSG00000057738 | Sptan1 | A3KGU6; A3KGU8; P16546; Q8K380; Q9CT05 | FAS pathway and stress induction of HSP regulation | Neutrophil degranulation; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Interaction between L1 and Ankyrins; COPI-mediated anterograde transport; RHOU GTPase cycle; RHOV GTPase cycle; Caspase-mediated cleavage of cytoskeletal proteins | 0.929383260195332 | 0.870511801558508 | 1427277.73205798 | 3976922.979229001 | 9978258.42723309 | 2263434.85725903 | 8138355.29233573 | 1.0330846429966014 | 0.6652476915056309 |
| Cont_P13645 | Keratin, type I cytoskeletal 10 OS=Homo sapiens OX=9606 GN=KRT10 PE=1 SV=6 | 286.713 | cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes | plasma membrane;cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;other molecular function | 3858 | ENSG00000186395 | KRT10 | hsa:3858; P13645; Q14664; Q8N175 | Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.829734761131295 | 0.246231694954624 | 9.409796786421584E7 | 1.13950700113199E8 | 6.71694026550819E7 | 3.19749190691826E8 | 1.0914077913761683E8 | -0.06221954053344878 | 1.7647052355257151 | |
| Cont_P35908 | Keratin, type II cytoskeletal 2 epidermal OS=Homo sapiens OX=9606 GN=KRT2 PE=1 SV=2 | 284.975 | cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes | plasma membrane;cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;cytoskeletal activity | 3849 | ENSG00000172867 | KRT2 | hsa:3849; P35908; Q4VAQ2 | Formation of the cornified envelope | 0.912218866069753 | 0.309041843038519 | 2.9357809740500167E7 | 3.415287514761583E7 | 1.8123682357997265E7 | 7.640800383787991E7 | 3.617272663897294E7 | 0.0828953136099207 | 1.3799794314161524 | |
| Q62059 | Versican core protein [OS=Mus musculus] | 279.715 | cell adhesion;developmental processes | non-structural extracellular;extracellular matrix;other cell component | other molecular function | Vcan | Q62058; Q62059; Q9CUU0 | ECM proteoglycans; Glycosaminoglycan-protein linkage region biosynthesis; CS/DS degradation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; CS-GAG biosynthesis; DS-GAG biosynthesis | 0.854305439376382 | 0.478009151463064 | 9.037034497028168E7 | 9.467651077277745E7 | 6.45815395615126E7 | 5.89459061512507E7 | 9.510262638582683E7 | 0.006478645904816274 | -0.6164578097523755 | |||
| P10493 | Nidogen-1 [OS=Mus musculus] | 275.191 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | other molecular function | 18073 | ENSMUSG00000005397 | Nid1 | mmu:18073; P10493; Q3TKX9; Q8BQI3; Q8C3U8; Q8C9P6 | Laminin interactions; Degradation of the extracellular matrix | 0.013229256333524 | 1.0740690550749E-5 | 1.2120394496125467E8 | 1.2671518083095133E8 | 1.3280012723821335E8 | 9146738.193898173 | 3.1971627034095198E7 | -1.9867253039502062 | -3.7280354888144775 | |
| O88207 | Collagen alpha-1(V) chain [OS=Mus musculus] | 275.025 | cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes | extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12831 | ENSMUSG00000026837 | Col5a1 | A3KGE3; mmu:12831; O88207; Q3UG94; Q6F6B0 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | ECM proteoglycans; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; MET activates PTK2 signaling | 0.189625712887896 | 0.302671730722046 | 3577832.3612721 | 8562033.320911517 | 1.35263273373913E7 | 1386447.3981625708 | 3098568.0509616495 | -1.4663517968660993 | -1.367692910200405 |
| P37889 | Fibulin-2 [OS=Mus musculus] | 269.894 | other biological processes | non-structural extracellular | other molecular function | 14115 | ENSMUSG00000064080 | Fbln2 | G5E8B3; mmu:14115; P37889; Q9WUI2 | Molecules associated with elastic fibres | 0.453005417011507 | 0.290132264062119 | 6.556805587417743E7 | 8.021475911820169E7 | 7.423633042764436E7 | 3.00676966042863E7 | 4.93487108032657E7 | -0.700855313955825 | -1.1247787672414093 | |
| Q8VHX6 | Filamin-C [OS=Mus musculus] | 249.498 | cell organization and biogenesis;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity | 68794 | ENSMUSG00000068699 | Flnc | B2RY80; B9EKT2; mmu:68794; Q6PAI6; Q8VHX6; Q9JJ38 | Cell-extracellular matrix interactions | 0.976873891151678 | 0.933437821008547 | 1016453.1391661359 | 2089599.8263247435 | 6137929.999733508 | 1136666.5742976035 | 4459384.47065665 | 1.093617906439173 | 0.1612654161431754 | |
| Q04857 | Collagen alpha-1(VI) chain [OS=Mus musculus] | 248.981 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component | other molecular function | 12833 | ENSMUSG00000001119 | Col6a1 | mmu:12833; Q04857 | ECM proteoglycans; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Signaling by PDGF; NCAM1 interactions | 0.0353343473113635 | 0.115965329440656 | 5.0068940213435836E7 | 6.914260176814564E7 | 6.089353622953653E7 | 1.4473176745930666E7 | 1.9886194591010433E7 | -1.7978076624001023 | -1.7905343022837863 | |
| Cont_Q2UVX4 | Complement C3 OS=Bos taurus OX=9913 GN=C3 PE=1 SV=2 | 247.154 | cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular;other cell component | signal transduction activity or receptor binding;enzyme regulator activity | 280677 | ENSBTAG00000017280 | C3 | bta:280677; Q2KIZ4; Q2UVX4 | Complement and coagulation cascades; Complement activation, classical pathway | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Neutrophil degranulation; Peptide ligand-binding receptors; G alpha (i) signalling events; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade; Alternative complement activation; Activation of C3 and C5 | 0.87421335771164 | 0.591028379533681 | 1.84550126489547E7 | 1.5291804049274266E7 | 1.004110180479193E7 | 1.196234797265725E7 | 1.6127794015790733E7 | 0.07679049940163296 | -0.6255121365240285 |
| Q62261 | Spectrin beta chain, non-erythrocytic 1 [OS=Mus musculus] | 244.684 | cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 20742 | ENSMUSG00000020315 | Sptbn1 | A2AFU1; mmu:20742; Q3TEM7; Q5SQL8; Q5SQL9; Q62261; Q9QWJ7 | COPI-mediated anterograde transport; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; RHOU GTPase cycle; Interaction between L1 and Ankyrins; RHOV GTPase cycle | 0.937876734191067 | 0.664971370235365 | 920886.7046363313 | 2921004.358024217 | 7076390.486598223 | 2299979.2063157237 | 6417771.720584608 | 1.1356079634194152 | 1.3205252384353656 | |
| Q640N1 | Adipocyte enhancer-binding protein 1 [OS=Mus musculus] | 239.707 | protein metabolism;other biological processes | nucleus;other cell component | nucleic acid binding activity;other molecular function | 11568 | ENSMUSG00000020473 | Aebp1 | mmu:11568; O88442; Q3TVV5; Q3TWA7; Q3TX56; Q3TXB2; Q5NCI9; Q61281; Q640N1 | 0.534291750451691 | 0.145805028390539 | 3.9556778473622136E7 | 4.1143769603117764E7 | 4.694818678152809E7 | 1.8648394999714002E7 | 3.1901344171106894E7 | -0.3670567664350577 | -1.0848734687320578 | ||
| P57780 | Alpha-actinin-4 [OS=Mus musculus] | 239.42 | cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes | cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 60595 | ENSMUSG00000054808 | Actn4 | mmu:60595; P57780 | Primary focal segmental glomerulosclerosis (FSGS) | Platelet degranulation | 0.921882153462399 | 0.968364585136618 | 4580996.01302682 | 9830280.285985528 | 3.01659424163415E7 | 4440337.50144963 | 1.1658414413951913E7 | 0.24606713307090775 | -0.044991970039703705 |
| Q7TPR4 | Alpha-actinin-1 [OS=Mus musculus] | 235.529 | cell adhesion;cell organization and biogenesis;other biological processes | plasma membrane;other membranes;cytoskeleton;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function | 109711 | ENSMUSG00000015143 | Actn1 | mmu:109711; Q7TPR4 | Regulation of actin cytoskeleton; Integrin-mediated cell adhesion; Focal adhesion | Platelet degranulation ; RHOF GTPase cycle; RHOBTB2 GTPase cycle; RHOD GTPase cycle; Regulation of cytoskeletal remodeling and cell spreading by IPP complex components | 0.974207409660283 | 0.837231569641376 | 2525588.7379033365 | 6210475.170240924 | 1.99706831247943E7 | 3717490.65968503 | 9946958.94260729 | 0.679551866892813 | 0.5577093849474224 |
| P02468 | Laminin subunit gamma-1 [OS=Mus musculus] | 230.882 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | Lamc1 | P02468 | 0.3041568870489 | 0.368062651583427 | 7327169.184632126 | 1.61740059690847E7 | 2.6285654209548533E7 | 3246292.9185144133 | 7951596.802164167 | -1.0243605391840713 | -1.1744627453696188 | ||||
| Q91ZX7 | Prolow-density lipoprotein receptor-related protein 1 [OS=Mus musculus] | 230.497 | other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;other molecular function | 16971 | Lrp1 | mmu:16971; Q61291; Q91ZX7; Q920Y4 | Statin pathway; Wnt signaling pathway | Scavenging of heme from plasma; Retinoid metabolism and transport | 0.687557067265551 | 0.74148782464906 | 3548407.5296101067 | 7355877.025944923 | 9948732.886846773 | 2243610.9879279765 | 5724840.5342227295 | -0.3616618538572069 | -0.6613491570014096 | |
| Cont_P60712 | Actin, cytoplasmic 1 OS=Bos taurus OX=9913 GN=ACTB PE=1 SV=1 | 225.45 | cell organization and biogenesis;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component | enzyme regulator activity;cytoskeletal activity;other molecular function | 100033878; 100135470; 100173832; 101844587; 102139853; 11461; 118833809; 280979; 396526; 403580; 414396; 443052; 450133; 60; 81822 | ENSBTAG00000026199; ENSCAFG00000016020; ENSCAFG00030015381; ENSCAFG00040015695; ENSCPOG00000013467; ENSG00000075624; ENSMAUG00000008763; ENSMUSG00000029580; ENSOARG00040012985; ENSOARG00180022443; ENSOARG00185023855; ENSOARG00215030140; ENSOARG00225009314; ENSPPYG00000017336; ENSPTRG00000018890; ENSRNOG00000034254; ENSSSCG00000007585; ENSSSCG00030003451; ENSSSCG00035038792; ENSSSCG00040049462; ENSSSCG00045027458; ENSSSCG00050065025; ENSSSCG00055012597; ENSSSCG00060019124; ENSSSCG00065037921; ENSSSCG00070011353; ENSSSCG00105030144; ENSSSCG00110026965; ENSSSCG00115013637; ENSSSCG00130033784 | Actb; ACTB | A5D961; A5PKA1; bta:280979; cfa:403580; cpoc:100135470; csab:103246953; ecb:100033878; gga:396526; hsa:60; maua:101844587; mmu:11461; O18840; oas:443052; P02570; P60706; P60707; P60708; P60709; P60710; P60711; P60712; P60713; P70514; P99021; pon:100173832; ptr:450133; Q11209; Q11211; Q3SZD2; Q3TI89; Q3TVP6; Q4L0Y2; Q4R561; Q5R1X3; Q5R582; Q5R6G0; Q64316; Q6QAQ1; Q6ZWM3; Q711N9; Q71FK5; Q75MN2; Q76N69; Q8MIJ0; Q8SPX4; Q95164; Q96B34; Q96HG5; rno:81822; ssc:414396 | FAS pathway and stress induction of HSP regulation; Actin cytoskeleton regulation; Myometrial relaxation and contraction pathways; Focal adhesion; Arrhythmogenic right ventricular cardiomyopathy; Pathogenic Escherichia coli infection; Common pathways underlying drug addiction; Myometrial relaxation and contraction pathways; Focal adhesion; Fas ligand pathway and stress induction of heat shock proteins; Pathogenic Escherichia coli infection; Arrhythmogenic right ventricular cardiomyopathy; Focal adhesion; Myometrial relaxation and contraction pathways; Regulation of actin cytoskeleton; Myometrial relaxation and contraction pathways; Ebola virus infection in host; Acute viral myocarditis; Thermogenesis; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Overlap between signal transduction pathways contributing to LMNA laminopathies; Pleural mesothelioma; Regulation of actin cytoskeleton; Network map of SARS-CoV-2 signaling; Regulation of actin cytoskeleton; Regulation of actin cytoskeleton; Focal adhesion | Formation of the canonical BAF (cBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); Regulation of actin dynamics for phagocytic cup formation; EPH-ephrin mediated repulsion of cells; Formation of annular gap junctions; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; RHO GTPases Activate Formins; RHOF GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; B-WICH complex positively regulates rRNA expression; Regulation of CDH1 Function; Formation of the dystrophin-glycoprotein complex (DGC); Formation of the canonical BAF (cBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); RHO GTPases Activate WASPs and WAVEs; UCH proteinases; DNA Damage Recognition in GG-NER; Formation of the non-canonical BAF (ncBAF) complex; RHO GTPases activate IQGAPs; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Cell-extracellular matrix interactions; MAP2K and MAPK activation; Interaction between L1 and Ankyrins; RHOF GTPase cycle; DNA Damage Recognition in GG-NER; MAP2K and MAPK activation; RHO GTPases Activate Formins; Clathrin-mediated endocytosis; UCH proteinases; RHOF GTPase cycle; DNA Damage Recognition in GG-NER; EPH-ephrin mediated repulsion of cells; VEGFA-VEGFR2 Pathway; Regulation of actin dynamics for phagocytic cup formation; Adherens junctions interactions; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); RHO GTPases Activate WASPs and WAVEs; B-WICH complex positively regulates rRNA expression; Regulation of CDH1 Function; EPHB-mediated forward signaling; Formation of the non-canonical BAF (ncBAF) complex; Formation of the canonical BAF (cBAF) complex; Formation of annular gap junctions; RHO GTPases activate IQGAPs; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; RHO GTPases Activate WASPs and WAVEs; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RHO GTPases activate IQGAPs; RHO GTPases Activate Formins; RHOF GTPase cycle; Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs); B-WICH complex positively regulates rRNA expression; Signaling by BRAF and RAF1 fusions; UCH proteinases; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; VEGFA-VEGFR2 Pathway; Formation of the dystrophin-glycoprotein complex (DGC); Factors involved in megakaryocyte development and platelet production; Regulation of MITF-M-dependent genes involved in pigmentation; Formation of the canonical BAF (cBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); EPH-ephrin mediated repulsion of cells; HATs acetylate histones; Interaction between L1 and Ankyrins; Prefoldin mediated transfer of substrate to CCT/TriC; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Adherens junctions interactions; Regulation of CDH1 Function; Formation of the non-canonical BAF (ncBAF) complex; DNA Damage Recognition in GG-NER; Formation of the polybromo-BAF (pBAF) complex; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Formation of annular gap junctions; Folding of actin by CCT/TriC; Cell-extracellular matrix interactions; MAP2K and MAPK activation; RHO GTPases Activate Formins; Recycling pathway of L1; RHO GTPases activate IQGAPs; Clathrin-mediated endocytosis; Formation of the dystrophin-glycoprotein complex (DGC); EPHB-mediated forward signaling; UCH proteinases; B-WICH complex positively regulates rRNA expression; Adherens junctions interactions; Formation of the non-canonical BAF (ncBAF) complex; Formation of annular gap junctions; Formation of the polybromo-BAF (pBAF) complex; VEGFA-VEGFR2 Pathway; Cell-extracellular matrix interactions; RHO GTPases Activate WASPs and WAVEs; Regulation of CDH1 Function; Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; UCH proteinases; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); Formation of the polybromo-BAF (pBAF) complex; B-WICH complex positively regulates rRNA expression; DNA Damage Recognition in GG-NER; Formation of the canonical BAF (cBAF) complex; RHO GTPases Activate Formins; Regulation of CDH1 Function; Interaction between L1 and Ankyrins; RHOF GTPase cycle; Formation of the non-canonical BAF (ncBAF) complex; Adherens junctions interactions; Formation of the dystrophin-glycoprotein complex (DGC); VEGFA-VEGFR2 Pathway; RHO GTPases Activate WASPs and WAVEs; Cell-extracellular matrix interactions; EPHB-mediated forward signaling; MAP2K and MAPK activation; Recycling pathway of L1; RHO GTPases activate IQGAPs; Formation of annular gap junctions; B-WICH complex positively regulates rRNA expression; UCH proteinases; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); MAP2K and MAPK activation; Formation of the polybromo-BAF (pBAF) complex; RHO GTPases Activate Formins; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases Activate WASPs and WAVEs; Formation of the dystrophin-glycoprotein complex (DGC); VEGFA-VEGFR2 Pathway; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; DNA Damage Recognition in GG-NER; RHOF GTPase cycle; Cell-extracellular matrix interactions; Adherens junctions interactions; Formation of the non-canonical BAF (ncBAF) complex; Formation of the canonical BAF (cBAF) complex; RHO GTPases activate IQGAPs; Regulation of CDH1 Function; Gap junction degradation; Formation of annular gap junctions; Regulation of actin dynamics for phagocytic cup formation; RHOF GTPase cycle; Clathrin-mediated endocytosis; RHO GTPases Activate Formins; Cell-extracellular matrix interactions; VEGFA-VEGFR2 Pathway; Adherens junctions interactions; RHO GTPases activate IQGAPs; UCH proteinases; EPHB-mediated forward signaling; MAP2K and MAPK activation; RHO GTPases Activate WASPs and WAVEs; Formation of the dystrophin-glycoprotein complex (DGC); Formation of annular gap junctions; Formation of the canonical BAF (cBAF) complex; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of the non-canonical BAF (ncBAF) complex; Regulation of CDH1 Function | 0.946568086066385 | 0.963278515868644 | 4.828873920581084E7 | 6.5074451419171505E7 | 1.9003581889821532E8 | 5.335770948168167E7 | 1.0984219759318356E8 | 0.7552692448247239 | 0.14400994044310264 |
| P63260 | Actin, cytoplasmic 2 [OS=Mus musculus] | 217.791 | cell organization and biogenesis;stress response;developmental processes;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 11465 | ENSMUSG00000062825 | Actg1 | mmu:11465; P02571; P14104; P63260; P99022 | Myometrial relaxation and contraction pathways; Regulation of actin cytoskeleton; Focal adhesion | Platelet degranulation ; RHO GTPases activate IQGAPs; Adherens junctions interactions; Regulation of CDH1 Function; RHO GTPases Activate Formins; Regulation of actin dynamics for phagocytic cup formation; Interaction between L1 and Ankyrins; MAP2K and MAPK activation; Recycling pathway of L1; Clathrin-mediated endocytosis; Formation of the dystrophin-glycoprotein complex (DGC); EPHB-mediated forward signaling; RHOF GTPase cycle; Formation of annular gap junctions; VEGFA-VEGFR2 Pathway; Cell-extracellular matrix interactions; RHO GTPases Activate WASPs and WAVEs; RHOBTB2 GTPase cycle | 0.85271451854395 | 0.731487178650893 | 145698.54484736864 | 254666.434448248 | 751276.7484437827 | 126248.83655432604 | 256671.2110968777 | 0.011312666587244136 | -0.20671637589735362 |
| P33434 | 72 kDa type IV collagenase [OS=Mus musculus] | 212.03 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes | extracellular matrix;plasma membrane;other membranes;cytoskeleton;mitochondrion;nucleus;other cell component | other molecular function | 17390 | ENSMUSG00000031740 | Mmp2 | mmu:17390; P33434 | Lung fibrosis; IL-3 signaling pathway; Matrix metalloproteinases | Collagen degradation; Extra-nuclear estrogen signaling; EPH-ephrin mediated repulsion of cells; Activation of Matrix Metalloproteinases | 0.993994198406889 | 0.34519376377552 | 2.11513119484971E7 | 6.116415043649567E7 | 9.997674520202683E7 | 5.359802560613743E7 | 8.73371018908004E7 | 0.5139083514604432 | 1.3414327051154107 |
| P19096 | Fatty acid synthase [OS=Mus musculus] | 203.372 | other metabolic processes;stress response;other biological processes | plasma membrane;other membranes;cytosol;ER/Golgi;other cell component | other molecular function | 14104 | ENSMUSG00000025153 | Fasn | B1ATU8; mmu:14104; P19096; Q6PB72; Q8C4Z0; Q9EQR0 | Fatty acid biosynthesis; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-9 fatty acid synthesis; Elongation of (very) long chain fatty acids | Fatty acyl-CoA biosynthesis; Vitamin B5 (pantothenate) metabolism | 0.87421335771164 | 0.746782404466558 | 1389784.0897720233 | 2729524.669883373 | 1.0491585001659483E7 | 892753.3234074336 | 2995475.6339221266 | 0.1341353617926422 | -0.6385272655543875 |
| Cont_Q3SZ57 | Alpha-fetoprotein OS=Bos taurus OX=9913 GN=AFP PE=2 SV=1 | 202.89 | other metabolic processes;developmental processes;other biological processes | non-structural extracellular;other cell component | other molecular function | 506011 | ENSBTAG00000017131 | AFP | bta:506011; Q3SZ57 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 0.938859506774495 | 0.699570390946254 | 4.5317948160280704E7 | 3.6151020512819335E7 | 2.37647047257016E7 | 3.679174310656657E7 | 4.2915740009991035E7 | 0.2474705016386588 | -0.30070051296273864 | |
| P48678 | Prelamin-A/C [OS=Mus musculus] | 202.607 | cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes | other membranes;cytoskeleton;nucleus;other cell component | other molecular function | 16905 | ENSMUSG00000028063 | Lmna | B3RH23; B3RH24; mmu:16905; P11516; P48678; P97859; Q3TIH0; Q3TTS8; Q3U733; Q3U7I5; Q3UCA0; Q3UCJ8; Q3UCU3; Q91WF2; Q9DC21 | Adipogenesis genes; FAS pathway and stress induction of HSP regulation | 0.236076921565588 | 0.901149690306505 | 4134986.871037207 | 1.1058985470826533E7 | 3.2189609583199937E7 | 6289356.16248022 | 5.369543399964929E7 | 2.2795803719185894 | 0.6050295881452582 | |
| Q02788 | Collagen alpha-2(VI) chain [OS=Mus musculus] | 202.37 | cell adhesion;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component | other molecular function | 12834 | ENSMUSG00000020241 | Col6a2 | mmu:12834; Q02788; Q05505; Q8C972; Q8K229 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | ECM proteoglycans; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation | 0.156641881403766 | 0.0961283818482991 | 4.136492509189963E7 | 5.21291258166705E7 | 5.586648846604673E7 | 1.173163988850227E7 | 2.0595787144729633E7 | -1.3397404015276635 | -1.8180032772865453 |
| P97927 | Laminin subunit alpha-4 [OS=Mus musculus] | 199.33 | cell adhesion;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | signal transduction activity or receptor binding | 16775 | ENSMUSG00000019846 | Lama4 | mmu:16775; O88785; P70409; P97927; Q14BF2 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Formation of the dystrophin-glycoprotein complex (DGC); Laminin interactions; MET activates PTK2 signaling | 0.329011090732691 | 0.50594120050135 | 5125646.74812024 | 1.037511250312096E7 | 1.8735571837149E7 | 3065544.409694903 | 5760601.1965567535 | -0.8488356911350236 | -0.7415907489564434 |
| P20152 | Vimentin [OS=Mus musculus] | 183.446 | cell organization and biogenesis;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component | cytoskeletal activity;nucleic acid binding activity;other molecular function | 22352 | ENSMUSG00000026728 | Vim | mmu:22352; O08704; P20152; Q8CCH1 | Spinal cord injury; Primary focal segmental glomerulosclerosis (FSGS); Alpha 6 beta 4 integrin signaling pathway | Aggrephagy; Striated Muscle Contraction; Caspase-mediated cleavage of cytoskeletal proteins; RHOBTB1 GTPase cycle | 0.873609880131656 | 0.840672080806375 | 7365249.698992513 | 3.3401280645601466E7 | 8.643236711147267E7 | 1.292797841903164E7 | 7.464184195594883E7 | 1.1600811699488573 | 0.8116903529805907 |
| Q64727 | Vinculin [OS=Mus musculus] | 182.753 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | plasma membrane;other membranes;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 22330 | ENSMUSG00000021823 | Vcl | mmu:22330; Q64727; Q8BP32; Q8BS46; Q922C5; Q922D9 | Primary focal segmental glomerulosclerosis (FSGS); IL-3 signaling pathway; Regulation of actin cytoskeleton; Integrin-mediated cell adhesion; Focal adhesion | Neutrophil degranulation; High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells; Platelet degranulation ; MAP2K and MAPK activation; Smooth Muscle Contraction; Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells; Regulation of CDH1 Function | 0.964629994744883 | 0.977491813528386 | 1953982.7579073233 | 4840837.086136207 | 1.55412767194393E7 | 2359150.5810886133 | 6758257.200309387 | 0.48139471401466805 | 0.2718497696931775 |
| Q8K4G1 | Latent-transforming growth factor beta-binding protein 4 [OS=Mus musculus] | 180.216 | cell-cell signaling;cell organization and biogenesis;transport;signal transduction | non-structural extracellular;extracellular matrix | other molecular function | 108075 | ENSMUSG00000040488 | Ltbp4 | E9QPD9; mmu:108075; Q8K4G0; Q8K4G1 | TGF-beta receptor signaling activates SMADs; Molecules associated with elastic fibres | 0.775297640004946 | 0.703189639676216 | 1469976.6770863 | 2473680.681365607 | 4126124.1405319436 | 2657641.7444799202 | 7291299.088613093 | 1.5595166020390654 | 0.8543533743061732 | |
| Q68FD5 | Clathrin heavy chain 1 [OS=Mus musculus] | 180.117 | cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes | plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component | nucleic acid binding activity;other molecular function | 67300 | ENSMUSG00000047126 | Cltc | mmu:67300; Q68FD5 | IL-7 signaling pathway; Kit receptor signaling pathway | MHC class II antigen presentation; Recycling pathway of L1; Cargo recognition for clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis; LDL clearance; Retrograde neurotrophin signalling; Formation of annular gap junctions; Lysosome Vesicle Biogenesis; WNT5A-dependent internalization of FZD4; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation; RHOU GTPase cycle; RHOV GTPase cycle | 0.688274955487563 | 0.946476383814868 | 1426606.2225329466 | 2101059.0869428 | 7198111.7488871245 | 2078296.563295177 | 6830362.818457293 | 1.7008454796013681 | 0.5428143634365035 |
| P02469 | Laminin subunit beta-1 [OS=Mus musculus] | 179.863 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;nucleus;other cell component | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 16777 | ENSMUSG00000002900 | Lamb1 | E9PXZ9; P02469 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Inflammatory response pathway; Alpha 6 beta 4 integrin signaling pathway; Focal adhesion | 0.269583968882479 | 0.356773085915651 | 1.4326337702720901E7 | 1.8407714250900764E7 | 2.406357201653607E7 | 2.1078383512013834E7 | 1.149610392953332E7 | -0.6791654838846833 | 0.5570943768396376 | |
| Q01853 | Transitional endoplasmic reticulum ATPase [OS=Mus musculus] | 179.055 | cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;other biological processes | other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;enzyme regulator activity;other molecular function | 269523 | ENSMUSG00000028452 | Vcp | mmu:269523; Q01853; Q3TFH9; Q3TIM2; Q3TXN9; Q6PI18; Q8BSR6; Q8CEG4 | IL-9 signaling pathway | RHOH GTPase cycle; Neutrophil degranulation; Protein methylation; Ovarian tumor domain proteases; Neddylation; ABC-family proteins mediated transport; Translesion Synthesis by POLH; Hedgehog ligand biogenesis; KEAP1-NFE2L2 pathway; HSF1 activation; N-glycan trimming in the ER and Calnexin/Calreticulin cycle; Josephin domain DUBs | 0.953038161729767 | 0.901149690306505 | 5338414.413398174 | 9329554.935730066 | 2.5532499977727503E7 | 4463650.11042755 | 1.2770955118061693E7 | 0.45298626139298054 | -0.2581873602655405 |
| Q03350 | Thrombospondin-2 [OS=Mus musculus] | 178.303 | cell adhesion;other biological processes | non-structural extracellular;extracellular matrix;other cell component | other molecular function | 21826 | ENSMUSG00000023885 | Thbs2 | mmu:21826; Q03350; Q8CG21 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Signaling by PDGF; O-glycosylation of TSR domain-containing proteins | 0.792896707923278 | 0.620448351319483 | 7439397.130180354 | 1.1102887711296873E7 | 1.7857870851453733E7 | 4211942.301314384 | 1.05864549049655E7 | -0.06871539719065865 | -0.820700040470399 |
| Q80YX1 | Tenascin [OS=Mus musculus] | 175.9 | cell adhesion;cell-cell signaling;cell organization and biogenesis;stress response;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | signal transduction activity or receptor binding;other molecular function | 21923 | ENSMUSG00000028364 | Tnc | mmu:21923; Q64706; Q80YX1; Q80YX2 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Integrin cell surface interactions; ECM proteoglycans; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 1.08858887903907E-8 | 0.00972980877962454 | 1449614.4281484466 | 1.2106484504902953E7 | 3597849.650032737 | 96243.5238250637 | 211010.04547923067 | -5.842324501720179 | -3.9128359438342706 |
| Q61147 | Ceruloplasmin [OS=Mus musculus] | 175.43 | cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular | other molecular function | 12870 | ENSMUSG00000003617 | Cp | mmu:12870; Q61147; Q6P5C8 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Iron uptake and transport; Metal ion SLC transporters | 0.114472406028442 | 0.217345018530886 | 4703216.257241024 | 9598922.193485493 | 1.8258425380319133E7 | 1756646.5467629798 | 3587720.1567995367 | -1.4198050591681202 | -1.4208237326658222 | |
| Q3UQ28 | Peroxidasin homolog [OS=Mus musculus] | 173.636 | cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes | extracellular matrix;ER/Golgi;other cell component | extracellular structural activity;other molecular function | 69675 | ENSMUSG00000020674 | Pxdn | A4FU83; E9QNQ9; mmu:69675; Q3UQ28 | Crosslinking of collagen fibrils | 0.414844709855988 | 0.622521206052951 | 3468268.863888983 | 1.0141728842991263E7 | 7424302.20024892 | 1748064.7562207088 | 5865453.59009746 | -0.789989022164196 | -0.988457112373562 | |
| Q61316 | Heat shock 70 kDa protein 4 [OS=Mus musculus] | 169.044 | protein metabolism;other metabolic processes | other cell component | other molecular function | Hspa4 | Q61316 | Regulation of HSF1-mediated heat shock response | 0.937908804051419 | 0.905946265571965 | 1715523.4149199834 | 3885769.0116153997 | 1.2475039717842167E7 | 1450318.0074060035 | 4790126.20554149 | 0.3018635242804291 | -0.2422795462920771 | |||
| Cont_P02533 | Keratin, type I cytoskeletal 14 OS=Homo sapiens OX=9606 GN=KRT14 PE=1 SV=4 | 164.831 | cell organization and biogenesis;other biological processes | plasma membrane;cytosol;cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 3861 | ENSG00000186847 | KRT14 | hsa:3861; P02533; Q14715; Q53XY3; Q9BUE3; Q9UBN2; Q9UBN3; Q9UCY4 | Corticotropin-releasing hormone signaling | Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin; Developmental Lineage of Mammary Gland Myoepithelial Cells; Type I hemidesmosome assembly | 0.735573385767802 | 0.645534074006669 | 1.0299655985485494E7 | 9892865.41378706 | 7326107.9926405 | 2.9333304518974166E7 | 9460012.597296894 | -0.06454634544610054 | 1.5099434544998684 |
| P11499 | Heat shock protein HSP 90-beta [OS=Mus musculus] | 164.719 | cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component | enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function | 15516 | ENSMUSG00000023944 | Hsp90ab1 | mmu:15516; O89078; P11499; Q3UIQ7 | Focal adhesion: PI3K-Akt-mTOR signaling pathway | Neutrophil degranulation; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of actin dynamics for phagocytic cup formation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Attenuation phase; Estrogen-dependent gene expression; Sema3A PAK dependent Axon repulsion; Aryl hydrocarbon receptor signalling; DDX58/IFIH1-mediated induction of interferon-alpha/beta; HSF1 activation; RHOBTB2 GTPase cycle; The NLRP3 inflammasome | 0.952333191127893 | 0.975071223710592 | 1.0807613687705928E7 | 3.193268303009924E7 | 8.29576662608192E7 | 1.1608041082716169E7 | 4.22825068683512E7 | 0.4050271392280359 | 0.10307651810960865 |
| Q9JKF1 | Ras GTPase-activating-like protein IQGAP1 [OS=Mus musculus] | 163.926 | cell organization and biogenesis;developmental processes;signal transduction;other biological processes | plasma membrane;other membranes;cytoskeleton;nucleus;other cell component | enzyme regulator activity;other molecular function | 29875 | ENSMUSG00000030536 | Iqgap1 | G3UW45; mmu:29875; Q9JKF1 | G13 signaling pathway; Regulation of actin cytoskeleton | RHO GTPases activate IQGAPs; Neutrophil degranulation; RAC1 GTPase cycle; RAC2 GTPase cycle; RHOA GTPase cycle; MAP2K and MAPK activation; RHOQ GTPase cycle; RHOC GTPase cycle; RHOU GTPase cycle; RHOV GTPase cycle; Nephrin family interactions | 0.830676695521175 | 0.777195460870953 | 331165.4406654323 | 1068898.0084058929 | 3041433.200354057 | 944145.2185002686 | 3795509.9873349466 | 1.8281695465197003 | 1.5114566510612586 |
| P52480 | Pyruvate kinase PKM [OS=Mus musculus] | 163.393 | cell organization and biogenesis;other metabolic processes;other biological processes | cytosol;ER/Golgi;nucleus;other cell component | nucleic acid binding activity;kinase activity;other molecular function | 18746 | ENSMUSG00000032294 | Pkm | mmu:18746; P52480; Q3TBV8; Q3TBW5; Q3TC59; Q3U1X3; Q3U5P6; Q4VC20; Q64484; Q91YI8; Q9CWB1 | Glycolysis and gluconeogenesis; Purine metabolism | Neutrophil degranulation; Pyruvate metabolism; Glycolysis; Regulation of pyruvate metabolism | 0.938859506774495 | 0.958705855138011 | 1.1706302394897154E7 | 1.6687028973496003E7 | 3.53200761892009E7 | 1.3595916090065738E7 | 3.1698865102110166E7 | 0.9257040749614063 | 0.215887911460558 |
| P63017 | Heat shock cognate 71 kDa protein [OS=Mus musculus] | 161.557 | cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component | signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function | 15481 | ENSMUSG00000015656 | Hspa8 | mmu:15481; P08109; P12225; P63017; Q3U6R0; Q3U764; Q3U7D7; Q3U7E2; Q3U9B4; Q3U9G0; Q3UGM0; Q5FWJ6; Q62373; Q62374; Q62375; Q6NZD0 | Mapk signaling pathway; Exercise-induced circadian regulation | Neutrophil degranulation; mRNA Splicing - Major Pathway; Regulation of HSF1-mediated heat shock response; PKR-mediated signaling; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis; Attenuation phase; Lysosome Vesicle Biogenesis; GABA synthesis, release, reuptake and degradation; AUF1 (hnRNP D0) binds and destabilizes mRNA; Protein methylation | 0.987939278265184 | 0.709593139419252 | 1.5723480869725833E7 | 2.2348098618015703E7 | 7.359719450565854E7 | 1.2001189016638666E7 | 3.440867978172333E7 | 0.6226204469568586 | -0.38974328950384013 |
| Q9JHU4 | Cytoplasmic dynein 1 heavy chain 1 [OS=Mus musculus] | 161.009 | cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes | cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 13424 | ENSMUSG00000018707 | Dync1h1 | E9QM71; mmu:13424; Q9JHU4 | MHC class II antigen presentation; Neutrophil degranulation; Separation of Sister Chromatids; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; COPI-mediated anterograde transport; Recruitment of NuMA to mitotic centrosomes; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-independent Golgi-to-ER retrograde traffic; Aggrephagy; Anchoring of the basal body to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; AURKA Activation by TPX2 | 0.771389136401717 | 0.695927216301667 | 451351.8596347517 | 1275535.4534856554 | 3370818.0273642703 | 1462326.6297541 | 5162177.518126 | 2.0168767548265785 | 1.695941135437884 | |
| Q99K41 | EMILIN-1 [OS=Mus musculus] | 157.011 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 100952 | ENSMUSG00000029163 | Emilin1 | mmu:100952; Q99K41 | Molecules associated with elastic fibres | 0.169879542413978 | 0.0921665663508908 | 1671715.86234765 | 5498413.09956387 | 5014687.354848887 | 384416.66366236034 | 2364922.89508055 | -1.2172221542664499 | -2.120586876331411 | |
| Q61879 | Myosin-10 [OS=Mus musculus] | 146 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;nucleic acid binding activity;other molecular function | 77579 | ENSMUSG00000020900 | Myh10 | mmu:77579; Q5SV63; Q61879 | Regulation of actin cytoskeleton | RHO GTPases activate PAKs | 0.996007724449986 | 0.953146340313072 | 266023.60455562966 | 458865.269073755 | 1364536.1643212799 | 562909.3462758837 | 1089526.38375758 | 1.2475586126477243 | 1.0813483389566705 |
| Cont_P00761 | Trypsin OS=Sus scrofa OX=9823 PE=1 SV=1 | 143.502 | protein metabolism;other biological processes | non-structural extracellular | other molecular function | 0.822223648478518 | 0.960577895552113 | 3.334729419178533E9 | 2.1792138371661735E9 | 1.3557622678922963E9 | 4.479417756781787E9 | 2.35988129070601E9 | 0.11490652036236093 | 0.42574151472675936 | ||||||
| P20029 | Endoplasmic reticulum chaperone BiP [OS=Mus musculus] | 142.966 | protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component | enzyme regulator activity;translation activity;other molecular function | 14828 | ENSMUSG00000026864 | Hspa5 | mmu:14828; O35642; P20029; Q3UFF2; Q61630 | Mapk signaling pathway | Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Regulation of HSF1-mediated heat shock response | 0.916283277860523 | 0.985707795620743 | 7392689.481756757 | 8222965.927916382 | 1.797212351620547E7 | 8403011.594768586 | 1.57890948929286E7 | 0.9411977151669085 | 0.1848071583319896 |
| Cont_P13647 | Keratin, type II cytoskeletal 5 OS=Homo sapiens OX=9606 GN=KRT5 PE=1 SV=3 | 142.395 | cell organization and biogenesis;other biological processes | cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;cytoskeletal activity;other molecular function | 3852 | ENSG00000186081 | KRT5 | hsa:3852; P13647; Q6PI71; Q6UBJ0; Q8TA91 | Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin; Developmental Lineage of Mammary Stem Cells; Developmental Lineage of Mammary Gland Myoepithelial Cells; Type I hemidesmosome assembly | 0.873755746039336 | 0.2733017775894 | 7868513.182470503 | 9974982.226041706 | 1.0805570452735417E7 | 2.8752414910160065E7 | 1.3998817771053001E7 | 0.4889188179733309 | 1.8695201748341668 | |
| Cont_P08779 | Keratin, type I cytoskeletal 16 OS=Homo sapiens OX=9606 GN=KRT16 PE=1 SV=4 | 140.751 | cell organization and biogenesis;stress response;other biological processes | plasma membrane;cytosol;cytoskeleton | cytoskeletal activity | 3868 | ENSG00000186832 | KRT16 | A8K488; hsa:3868; P08779; P30654; Q16402; Q9UBG8 | Vitamin D receptor pathway | Formation of the cornified envelope | 0.82543231800733 | 0.895302208460818 | 3908256.3409277797 | 2249474.51763106 | 2096552.2825116366 | 5401589.786976026 | 2569640.8216647534 | 0.19197869304636359 | 0.46685898520849145 |
| Cont_P02465 | Collagen alpha-2(I) chain OS=Bos taurus OX=9913 GN=COL1A2 PE=1 SV=2 | 139.99 | non-structural extracellular;extracellular matrix | extracellular structural activity;other molecular function | 282188 | ENSBTAG00000013472 | COL1A2 | A6QP13; bta:282188; O62649; P02465 | Inflammatory response pathway; Focal adhesion | Fibronectin matrix formation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Collagen degradation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; Collagen chain trimerization; GPVI-mediated activation cascade; Platelet Aggregation (Plug Formation); Platelet Adhesion to exposed collagen; GP1b-IX-V activation signalling | 0.731850662833984 | 0.549852418071669 | 85775.39066064726 | 163731.944383145 | 196860.296999494 | 48702.045776696206 | 54970.44581499727 | -1.57460773663475 | -0.8165814161100421 | |
| Cont_P12763 | Alpha-2-HS-glycoprotein OS=Bos taurus OX=9913 GN=AHSG PE=1 SV=2 | 132.772 | stress response;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component | enzyme regulator activity | 280988 | AHSG | A6QLF7; bta:280988; P12763 | Neutrophil degranulation; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 0.946568086066385 | 0.335956814949331 | 8.712402787486216E8 | 6.41500953397899E8 | 4.2252677685996836E8 | 4.440672611032756E8 | 7.064361313920757E8 | 0.13910772352571524 | -0.9722924411478902 | ||
| P07901 | Heat shock protein HSP 90-alpha [OS=Mus musculus] | 132.382 | cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component | signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function | 15519 | ENSMUSG00000021270 | Hsp90aa1 | mmu:15519; P07901 | EBV LMP1 signaling; Focal adhesion: PI3K-Akt-mTOR signaling pathway; IL-6 signaling pathway; IL-2 signaling pathway | Regulation of necroptotic cell death; Recruitment of NuMA to mitotic centrosomes; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of actin dynamics for phagocytic cup formation; Neutrophil degranulation; Downregulation of ERBB2 signaling; Anchoring of the basal body to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; AURKA Activation by TPX2; Extra-nuclear estrogen signaling; Attenuation phase; Estrogen-dependent gene expression; Sema3A PAK dependent Axon repulsion; VEGFR2 mediated vascular permeability; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation; DDX58/IFIH1-mediated induction of interferon-alpha/beta; eNOS activation; HSF1 activation; RHOBTB2 GTPase cycle; Drug-mediated inhibition of ERBB2 signaling | 0.974827674952665 | 0.968364585136618 | 1667357.9717776468 | 3968795.71909318 | 1.1896107480962433E7 | 1606774.576019598 | 6014683.841021903 | 0.5997875986262169 | -0.0533963366441969 |
| Q02819 | Nucleobindin-1 [OS=Mus musculus] | 131.152 | signal transduction | non-structural extracellular;other membranes;ER/Golgi | enzyme regulator activity;nucleic acid binding activity;other molecular function | 18220 | ENSMUSG00000030824 | Nucb1 | mmu:18220; Q02819; Q3TU42; Q9CWA1; Q9D8J4; Q9DBL3 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 0.0679830640731695 | 0.397987186613988 | 5493436.34719679 | 1.9240052036173E7 | 2.4992726743775133E7 | 2379424.5332984333 | 6548209.148806977 | -1.5549403938694841 | -1.2070961924278651 | |
| Q91V92 | ATP-citrate synthase [OS=Mus musculus] | 129.973 | other metabolic processes | cytosol | other molecular function | 104112 | ENSMUSG00000020917 | Acly | mmu:104112; Q91V92 | Fatty acid biosynthesis | Neutrophil degranulation; Fatty acyl-CoA biosynthesis | 0.626059420687734 | 0.643183834410259 | 1276919.6113413726 | 2339759.4103227933 | 7993361.0560920695 | 644183.8162072281 | 1777761.9344937534 | -0.39629804848056854 | -0.9871233812801825 |
| A2ASQ1 | Agrin [OS=Mus musculus] | 128.989 | cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cell component | signal transduction activity or receptor binding;other molecular function | 11603 | ENSMUSG00000041936 | Agrn | A2ASP9; A2ASQ0; A2ASQ1; B2RWU1 | Primary focal segmental glomerulosclerosis (FSGS) | ECM proteoglycans; Retinoid metabolism and transport; Glycosaminoglycan-protein linkage region biosynthesis; HS-GAG biosynthesis; HS-GAG degradation; Formation of the dystrophin-glycoprotein complex (DGC) | 0.460727828548759 | 0.686318824668434 | 1695001.2322350666 | 3018900.06344302 | 4324221.40670855 | 1028829.4241236168 | 2045725.4701757336 | -0.561410446190177 | -0.72028251328634 |
| Q61508 | Extracellular matrix protein 1 [OS=Mus musculus] | 127.379 | stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular | signal transduction activity or receptor binding;other molecular function | 13601 | ENSMUSG00000028108 | Ecm1 | mmu:13601; Q3U5Q5; Q61508 | Platelet degranulation | 2.27890527565265E-4 | 1.51989274634622E-7 | 5.132626536679041E7 | 6.196550035866306E7 | 5.7086940781247534E7 | 3515293.344106073 | 1.1331897286900917E7 | -2.4510757802272813 | -3.8679803006942106 | |
| Cont_P04259 | Keratin, type II cytoskeletal 6B OS=Homo sapiens OX=9606 GN=KRT6B PE=1 SV=5 | 126.901 | cell organization and biogenesis;other biological processes | cytosol;cytoskeleton | bone, tooth or skin structural activity;cytoskeletal activity | 3854 | ENSG00000185479 | KRT6B | hsa:3854; P04259; P48669 | Formation of the cornified envelope | 0.854305439376382 | 0.937453377971347 | 1156058.5455969477 | 510017.07482617133 | 452820.542152991 | 1115770.6869766254 | 854901.7358096777 | 0.7452130553684702 | -0.05117390608584228 | |
| P17182 | Alpha-enolase [OS=Mus musculus] | 126.804 | other metabolic processes;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;other cell component | nucleic acid binding activity;other molecular function | 13806; 433182 | ENSMUSG00000059040; ENSMUSG00000063524 | Eno1 | mmu:13806; mmu:433182; P17182; Q99KT7; Q9DCY7 | Glycolysis and gluconeogenesis | 0.720832939248489 | 0.858218537342417 | 9473047.660860082 | 1.1146559483992001E7 | 2.0899983974591535E7 | 1.3905788568310633E7 | 2.89416009584274E7 | 1.3765462552828784 | 0.5537850111265004 | |
| P08113 | Endoplasmin [OS=Mus musculus] | 126.346 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cell component | signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function | 22027 | ENSMUSG00000020048 | Hsp90b1 | mmu:22027; P08113; P11427 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Hypoxia-dependent self-renewal of myoblasts | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Scavenging by Class A Receptors; Trafficking and processing of endosomal TLR; Interleukin-4 and Interleukin-13 signaling | 0.854305439376382 | 0.866766165039268 | 4030450.84914005 | 5006439.15200075 | 1.2828763316623202E7 | 6037105.20140975 | 1.2434595462188734E7 | 1.3125028215609296 | 0.5829157128019473 |
| P58252 | Elongation factor 2 [OS=Mus musculus] | 126.048 | cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;translational apparatus;other cell component | cytoskeletal activity;translation activity;nucleic acid binding activity;other molecular function | 13629 | ENSMUSG00000034994 | Eef2 | mmu:13629; P58252; Q544E4 | Translation factors | Neutrophil degranulation; Protein methylation; Peptide chain elongation; Synthesis of diphthamide-EEF2 | 0.922179983282929 | 0.866546043492515 | 6414138.274151959 | 1.0566307796994643E7 | 2.9620591728864197E7 | 4859646.5618234025 | 1.3065706600835832E7 | 0.3063138071523588 | -0.4004040637211755 |
| Cont_P02538 | Keratin, type II cytoskeletal 6A OS=Homo sapiens OX=9606 GN=KRT6A PE=1 SV=3 | 123.757 | cell organization and biogenesis;stress response;other biological processes | cytosol;cytoskeleton | bone, tooth or skin structural activity;cytoskeletal activity | 3853 | ENSG00000205420 | KRT6A | A4QPC1; hsa:3853; P02538; P48667; Q08AR4; Q6NT67; Q96CL4 | Ectoderm differentiation; Ectoderm differentiation; Pancreatic cancer subtypes | Formation of the cornified envelope | 0.792564971776066 | 0.709593139419252 | 4785085.111074816 | 3779160.7730984767 | 3044210.664784646 | 8485501.699692694 | 3982846.61307857 | 0.07573402481836149 | 0.826455374898488 |
| P97298 | Pigment epithelium-derived factor [OS=Mus musculus] | 123.502 | cell cycle OR cell proliferation;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | enzyme regulator activity | 20317 | ENSMUSG00000000753 | Serpinf1 | mmu:20317; O70629; O88691; P97298 | 0.00901230529014985 | 0.300753028734261 | 1.46490289953418E7 | 7.121805491857927E7 | 6.883649650666605E7 | 5921015.69252881 | 1.5757205380580032E7 | -2.1762313456020066 | -1.3068884569216235 | ||
| Q70E20 | Sushi, nidogen and EGF-like domain-containing protein 1 [OS=Mus musculus] | 122.942 | cell adhesion | non-structural extracellular;extracellular matrix | other molecular function | 208777 | Sned1 | A6H6I3; mmu:208777; Q70E20; Q810H2; Q8BMD9 | 0.889058672589993 | 0.817293288705596 | 3293936.3484006864 | 6267209.5561869135 | 8981713.661313256 | 4995161.517920501 | 1.4223395042125002E7 | 1.1823707306994269 | 0.6007186512533814 | |||
| P13020 | Gelsolin [OS=Mus musculus] | 122.934 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 227753 | ENSMUSG00000026879 | Gsn | mmu:227753; P13020; Q3UPB1; Q8R590 | Regulation of actin cytoskeleton | Neutrophil degranulation; Caspase-mediated cleavage of cytoskeletal proteins | 0.65414435708462 | 0.709593139419252 | 6438031.44422588 | 9825643.045518672 | 2.1865108079878632E7 | 1.1033925013460701E7 | 2.9144067496602204E7 | 1.5685785077495134 | 0.7772545527981521 |
| Q61398 | Procollagen C-endopeptidase enhancer 1 [OS=Mus musculus] | 120.4 | protein metabolism;other biological processes | enzyme regulator activity;other molecular function | 18542 | ENSMUSG00000029718 | Pcolce | mmu:18542; O35113; Q61398 | mRNA processing | Collagen biosynthesis and modifying enzymes; Crosslinking of collagen fibrils | 0.133905327763598 | 0.0895861566882082 | 2.52047208020085E7 | 2.958750643636163E7 | 3.717663177971887E7 | 7672570.19904635 | 1.2538308810459368E7 | -1.2386453468264698 | -1.7159121278098002 | |
| P26039 | Talin-1 [OS=Mus musculus] | 118.226 | cell adhesion;cell organization and biogenesis;signal transduction | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;other molecular function | 21894 | ENSMUSG00000028465 | Tln1 | A2AIM8; mmu:21894; P26039; Q8VEF0 | Primary focal segmental glomerulosclerosis (FSGS); Integrin-mediated cell adhesion; Focal adhesion | Platelet degranulation ; MAP2K and MAPK activation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; Smooth Muscle Contraction; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 0.850917681937748 | 0.87222702623065 | 165904.24421521465 | 567933.664164035 | 2047443.5453512298 | 286851.2614141297 | 2291518.0404973766 | 2.0125093088074704 | 0.7899520679334946 |
| Q8BPB5 | EGF-containing fibulin-like extracellular matrix protein 1 [OS=Mus musculus] | 117.738 | protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes | extracellular matrix | signal transduction activity or receptor binding;kinase activity;other molecular function | 216616 | ENSMUSG00000020467 | Efemp1 | mmu:216616; Q6Y3N6; Q8BPB5 | 0.278244203695445 | 0.145805028390539 | 4441372.613318663 | 7007290.288389671 | 9374363.446007233 | 1370373.3251651835 | 3606517.1409647237 | -0.9582503828225413 | -1.6964366384968077 | ||
| P09411 | Phosphoglycerate kinase 1 [OS=Mus musculus] | 116.462 | protein metabolism;other metabolic processes;stress response;other biological processes | non-structural extracellular;other membranes;cytosol;mitochondrion;other cell component | kinase activity;other molecular function | 18655 | ENSMUSG00000062070 | Pgk1 | mmu:18655; P09411; Q3TPE6; Q3UKV8; Q5XJE7 | Glycolysis and gluconeogenesis | Gluconeogenesis; Glycolysis | 0.465126095372736 | 0.820281310709571 | 3210948.6178334034 | 3594147.655304653 | 7046094.17133664 | 4500077.619792943 | 1.4795712145397767E7 | 2.041457553634679 | 0.48695030706009684 |
| P27773 | Protein disulfide-isomerase A3 [OS=Mus musculus] | 115.891 | cell adhesion;cell organization and biogenesis;stress response;signal transduction;other biological processes | non-structural extracellular;other membranes;ER/Golgi;other cell component | nucleic acid binding activity;other molecular function | 14827 | ENSMUSG00000027248 | Pdia3 | mmu:14827; P27773; Q3TEI9; Q3TIL2; Q3UZK8; Q8C2F4; Q99LF6 | ER-Phagosome pathway; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Calnexin/calreticulin cycle | 0.850917681937748 | 0.881496352314601 | 5161827.016313557 | 6480316.532156386 | 1.845644105269933E7 | 7238345.98431998 | 1.5315044241817234E7 | 1.2408133459469528 | 0.48777827396885565 | |
| P10107 | Annexin A1 [OS=Mus musculus] | 115.566 | cell organization and biogenesis;stress response;transport;signal transduction;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component | enzyme regulator activity;other molecular function | 16952 | ENSMUSG00000024659 | Anxa1 | mmu:16952; P10107 | Spinal cord injury; Prostaglandin synthesis and regulation | G alpha (q) signalling events; G alpha (i) signalling events; Formyl peptide receptors bind formyl peptides and many other ligands | 0.954328834404239 | 0.529099828181544 | 1675870.316312303 | 6017153.19339518 | 1.1246783571413433E7 | 4211649.667813237 | 1.08370832078509E7 | 0.8488235161720351 | 1.3294749220803617 |
| Cont_Q2KJF1 | Alpha-1B-glycoprotein OS=Bos taurus OX=9913 GN=A1BG PE=1 SV=1 | 115.502 | signal transduction | non-structural extracellular;plasma membrane;other membranes | 518955 | A1BG | bta:518955; Q2KJF1 | Platelet degranulation ; Neutrophil degranulation | 0.932231143665149 | 0.601376052147163 | 9820849.23751892 | 8859077.038578315 | 5863583.3120338395 | 6762503.63408608 | 1.0317459698123023E7 | 0.21985949488281362 | -0.5382903197621131 | |||
| Cont_Q3MHN5 | Vitamin D-binding protein OS=Bos taurus OX=9913 GN=GC PE=2 SV=1 | 113.599 | other metabolic processes;transport | non-structural extracellular;other cell component | transporter activity;cytoskeletal activity;other molecular function | 530076 | GC | bta:530076; Q3MHN5 | 0.946173787415917 | 0.570795727084329 | 1.5974245944817802E7 | 1.026921939097026E7 | 8132938.425379939 | 1.0785165311962552E7 | 1.4618596373270534E7 | 0.5094782752262966 | -0.5666995412925446 | |||
| P17742 | Peptidyl-prolyl cis-trans isomerase A [OS=Mus musculus] | 113.527 | cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes | non-structural extracellular;cytosol;nucleus;other cell component | signal transduction activity or receptor binding;other molecular function | 268373 | ENSMUSG00000071866 | Ppia | mmu:268373; P17742; Q9CWJ5; Q9R137 | Neutrophil degranulation; Basigin interactions | 0.946239447314336 | 0.937453377971347 | 1.0145464905716315E7 | 3.610988970082183E7 | 6.97111893668837E7 | 1.0696784170781441E7 | 4.607074026803666E7 | 0.3514567659376412 | 0.07634216032534753 | |
| Q69ZN7 | Myoferlin [OS=Mus musculus] | 112.647 | cell organization and biogenesis;other metabolic processes;stress response;other biological processes | plasma membrane;other membranes;nucleus | other molecular function | 226101 | ENSMUSG00000048612 | Myof | mmu:226101; Q69ZN7; Q7TMG0; Q80V33; Q8BU64; Q8BU70; Q8BUC1; Q8BVY6; Q8C0D1; Q8R3B4 | 0.816275429153737 | 0.609903091678244 | 322363.41862436634 | 911704.7850761963 | 2642353.10757036 | 1104935.9693987637 | 3065805.015040973 | 1.7496272919339693 | 1.7772028252973333 | ||
| P26041 | Moesin [OS=Mus musculus] | 112.068 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function | 17698 | ENSMUSG00000031207 | Msn | B1AX70; mmu:17698; P26041; Q3UL28; Q8BSN4 | Regulation of actin cytoskeleton | Recycling pathway of L1 | 0.910750689050232 | 0.97925982662951 | 9136364.2843242 | 1.7052591672350097E7 | 3.507274229077233E7 | 1.120013397828275E7 | 1.9030746620886367E7 | 0.15834114468472432 | 0.29382391022615884 |
| P05064 | Fructose-bisphosphate aldolase A [OS=Mus musculus] | 112.015 | cell organization and biogenesis;other metabolic processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | other molecular function | 11674 | ENSMUSG00000030695 | Aldoa | mmu:11674; P05064 | Glycolysis and gluconeogenesis | Platelet degranulation ; Neutrophil degranulation; Gluconeogenesis; Glycolysis | 0.907383519445145 | 0.988377544628277 | 4319055.57861477 | 4893427.94836492 | 1.3571821307477335E7 | 4518789.603964283 | 1.0653934694757948E7 | 1.1224689803597754 | 0.0652205047103212 |
| B2RQC6 | Multifunctional protein CAD [OS=Mus musculus] | 111.853 | other metabolic processes;stress response;transport;developmental processes;other biological processes | cytosol;nucleus;other cell component | kinase activity;other molecular function | 69719 | ENSMUSG00000013629 | Cad | B2RQC6; B7ZN27; mmu:69719 | Mechanisms associated with pluripotency | Pyrimidine biosynthesis | 0.340675523776301 | 0.798180783050573 | 448793.6641228067 | 957747.5456383955 | 3728337.7638301034 | 139659.55402474166 | 452794.3373622177 | -1.0807895075821645 | -1.6841380378584145 |
| Q8BND5 | Sulfhydryl oxidase 1 [OS=Mus musculus] | 111.186 | cell organization and biogenesis;other biological processes | non-structural extracellular;other membranes;ER/Golgi | other molecular function | 104009 | ENSMUSG00000033684 | Qsox1 | mmu:104009; Q3TDY9; Q3TE19; Q3TR29; Q3UEL4; Q8BND5; Q8K041; Q9DBL6 | Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Neutrophil degranulation | 0.203109767081086 | 0.331332346840573 | 3849451.1157268733 | 1.052758137572049E7 | 1.39599253643295E7 | 1818282.5759143168 | 5040172.36278756 | -1.0626290505699043 | -1.082076326435299 |
