Selected Cell
Cell:
Value:
All identified Proteins
Applied filters
Filtered proteins
Normalized avg abundances
only_avg_abundances
t-test_CM-LQ_vs_FM
t-test_CM-SQ_vs_NC
t-test CM-SQ_vs_CM-LQ
A
B
C
D
E
F
G
H
I
J
K
L
M
N
O
P
Q
R
S
T
U
V
W
X
Y
Z
AA
AB
AC
AD
AE
AF
AG
AH
AI
AJ
AK
AL
AM
AN
AO
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
| Accession | Description | Sum PEP Score | Coverage [%] | # Peptides | # PSMs | # Unique Peptides | # AAs | MW [kDa] | Biological Process | Cellular Component | Molecular Function | Entrez Gene ID | Ensembl Gene ID | Gene Symbol | Gene ID | WikiPathways | Reactome Pathways | Abundance Ratio Adj. P-Value: (LQ_16h) / FM | Abundance Ratio Adj. P-Value: (LQ_6h) / FM | Abundance Ratio Adj. P-Value: (SQ_16h) / FM | Abundance Ratio Adj. P-Value: (SQ_6h) / FM | Abundance Ratio Adj. P-Value: (SQ_16h) / (LQ_16h) | Abundance Ratio Adj. P-Value: (LQ_16h) / (LQ_6h) | Abundance Ratio Adj. P-Value: (SQ_6h) / (LQ_6h) | Abundance Ratio Adj. P-Value: (SQ_16h) / (SQ_6h) | Abundances (Normalized): F1: Sample, FM | Abundances (Normalized): F2: Sample, FM | Abundances (Normalized): F3: Sample, FM | Abundances (Normalized): F8: Sample, LQ_16h | Abundances (Normalized): F9: Sample, LQ_16h | Abundances (Normalized): F10: Sample, LQ_16h | Abundances (Normalized): F4: Sample, LQ_6h | Abundances (Normalized): F5: Sample, LQ_6h | Abundances (Normalized): F6: Sample, LQ_6h | Abundances (Normalized): F17: Sample, SQ_16h | Abundances (Normalized): F18: Sample, SQ_16h | Abundances (Normalized): F20: Sample, SQ_16h | Abundances (Normalized): F14: Sample, SQ_6h | Abundances (Normalized): F15: Sample, SQ_6h | Abundances (Normalized): F16: Sample, SQ_6h |
| P62962 | Profilin-1 [OS=Mus musculus] | 63.691 | 91 | 10 | 188 | 10 | 140 | 14.9 | cell organization and biogenesis;developmental processes;other biological processes | non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 18643 | ENSMUSG00000018293 | Pfn1 | mmu:18643; P10924; P62962 | G13 signaling pathway; Regulation of actin cytoskeleton | RHO GTPases Activate Formins; PCP/CE pathway; Signaling by ROBO receptors | 0.411535094328401 | 0.77316053068875 | 0.31701726971249 | 0.946783524828663 | 0.996007724449986 | 0.656158656510427 | 0.877696436885309 | 0.181694204221762 | 655800.017363376 | 143095.091219364 | 419057.751872435 | 4206326.28321379 | 4304878.08309123 | 4747457.58796751 | 1585843.6272586 | 1475995.81484065 | 2000183.41053967 | 7260167.55249118 | 5007652.33533127 | 6263979.57428718 | 1252103.50974388 | 886258.51164894 | 2014688.94704861 |
| P16045 | Galectin-1 [OS=Mus musculus] | 63.154 | 84 | 9 | 160 | 9 | 135 | 14.9 | cell adhesion;signal transduction;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;other cell component | signal transduction activity or receptor binding;other molecular function | 16852 | ENSMUSG00000068220 | Lgals1 | mmu:16852; P05163; P11946; P16045; P17601; Q4FZH4; Q99M27; Q9D0X0 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 0.214793183779243 | 0.758649115689172 | 0.862423503077705 | 0.00322600286143261 | 0.0393290691176906 | 14936.2360725546 | 1.08047842947433E7 | 9599768.14000291 | 8687088.34781577 | 8531853.83491426 | 6908469.78338064 | 7711238.13686352 | 7982203.8536903 | 8824565.06426897 | 7659481.69651213 | 1460635.09603453 | 709314.615558924 | 2150770.87975978 | |||
| O08997 | Copper transport protein ATOX1 [OS=Mus musculus] | 20.78 | 84 | 4 | 42 | 4 | 68 | 7.3 | stress response;transport;other biological processes | cytosol | other molecular function | 11927 | ENSMUSG00000018585 | Atox1 | mmu:11927; O08997; Q5NCU2 | Comprehensive IL-17A signaling | Ion influx/efflux at host-pathogen interface | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.944154202827561 | 0.96786708205164 | 0.557420493212927 | 0.421690313651007 | 551478.266640532 | 313405.851832555 | 677509.482604148 | 306540.186990902 | 295618.985256534 | 331367.2805474 | 971226.606629803 | 627950.630697459 | 441385.272387758 | 96182.1370331154 | 81203.860885215 | 83537.7620395082 | |||
| P70296 | Phosphatidylethanolamine-binding protein 1 [OS=Mus musculus] | 63.309 | 82 | 9 | 96 | 9 | 187 | 20.8 | other biological processes | other cell component | enzyme regulator activity;other molecular function | 23980 | ENSMUSG00000032959 | Pebp1 | mmu:23980; P70296; Q9D8G9; Q9JJ58 | EGFR1 signaling pathway | MAP2K and MAPK activation; Negative regulation of MAPK pathway | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.925217760894268 | 0.809979985251567 | 0.767145247888963 | 0.0682902444293211 | 3469816.49765495 | 3146472.32490885 | 3800847.10397996 | 1755656.74535333 | 1292410.19767497 | 2385194.3198318 | 8075338.47714044 | 6464100.37053227 | 6339151.57068833 | 1267788.46230452 | 783488.191861636 | 1983037.39117649 | |||
| Cont_P02769 | Albumin OS=Bos taurus OX=9913 GN=ALB PE=1 SV=4 | 390.555 | 81 | 57 | 7095 | 54 | 607 | 69.2 | stress response;other biological processes | non-structural extracellular;other cell component | nucleic acid binding activity;other molecular function | 280717 | ALB | A5PJX3; bta:280717; O02787; P02769; P04277; Q3SZR2 | 0.520832629933248 | 0.650544967914241 | 0.598172767155558 | 0.497906326712893 | 0.946568086066385 | 0.413798631523592 | 0.846117085258013 | 0.468531677746422 | 3.41035277502904E9 | 3.06531085647989E9 | 1.66716629813739E9 | 2.0547979326133E9 | 2.37062763488737E9 | 2.78500610382043E9 | 3.09362764542436E9 | 2.55631644026836E9 | 3.07992745656962E9 | 2.97814649224141E9 | 2.86277256421772E9 | 2.21144220575444E9 | 1.66052966718895E9 | 2.22855277531216E9 | 3.25384623573346E9 | |||
| Q01149 | Collagen alpha-2(I) chain [OS=Mus musculus] | 773.662 | 80 | 66 | 1731 | 51 | 1372 | 129.5 | cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12843 | ENSMUSG00000029661 | Col1a2 | mmu:12843; Q01149; Q8CGA5 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Focal adhesion | Crosslinking of collagen fibrils; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; ECM proteoglycans; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; GPVI-mediated activation cascade; GP1b-IX-V activation signalling; Platelet Adhesion to exposed collagen; Platelet Aggregation (Plug Formation); MET activates PTK2 signaling | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.0150838661305169 | 0.862063111456553 | 0.0347692006632991 | 0.926292871155025 | 217896.573253055 | 102775.453905646 | 225868.955510701 | 3.82374533805921E8 | 3.80614155239716E8 | 2.79801552870279E8 | 1.73556920519588E8 | 1.55763113653521E8 | 1.89931753802048E8 | 1.03217412397752E8 | 1.04517075360638E8 | 6.33578194684048E7 | 4.96147162399626E7 | 2.65479311979207E7 | 5.19818116295111E7 |
| P11087 | Collagen alpha-1(I) chain [OS=Mus musculus] | 797.017 | 79 | 75 | 1933 | 35 | 1453 | 137.9 | cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12842 | ENSMUSG00000001506 | Col1a1 | mmu:12842; P11087; Q53WT0; Q60635; Q61367; Q61427; Q63919; Q6PCL3; Q810J9 | Osteoblast signaling; Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Comprehensive IL-17A signaling; Focal adhesion | Cell surface interactions at the vascular wall; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ECM proteoglycans; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; GPVI-mediated activation cascade; GP1b-IX-V activation signalling; Platelet Adhesion to exposed collagen; Platelet Aggregation (Plug Formation); MET activates PTK2 signaling | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 1.58880673198775E-4 | 0.381922652011049 | 0.0629214061377862 | 0.655833157547641 | 703080.609341466 | 1047026.5902454 | 567207.050774397 | 6.12803341835757E8 | 6.28616080368892E8 | 5.37143706349406E8 | 2.20652487774689E8 | 1.86114398805651E8 | 2.17194307013081E8 | 9.46570689754052E7 | 9.72166914362706E7 | 6.09758172025116E7 | 6.01286898886734E7 | 4.84358218594371E7 | 7.06441702532683E7 |
| Cont_P35908 | Keratin, type II cytoskeletal 2 epidermal OS=Homo sapiens OX=9606 GN=KRT2 PE=1 SV=2 | 284.975 | 78 | 42 | 1022 | 32 | 639 | 65.4 | cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes | plasma membrane;cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;cytoskeletal activity | 3849 | ENSG00000172867 | KRT2 | hsa:3849; P35908; Q4VAQ2 | Formation of the cornified envelope | 0.499413631103761 | 0.411258958244596 | 0.544106843431104 | 0.933570718645937 | 0.912218866069753 | 0.862063111456553 | 0.309041843038519 | 2.9837536993241E-4 | 2.56957016834685E7 | 6.51011422173888E7 | 5.25056794690703E7 | 3.16465014359267E7 | 4.04662454773149E7 | 3.03458785296059E7 | 2.58420950665494E7 | 4.44581259999837E7 | 1.77732081549674E7 | 3.88601529372083E7 | 2.41897353529024E7 | 4.54682916268081E7 | 9.79668081708945E7 | 6.73715830359901E7 | 6.38856203067551E7 | |
| Cont_Q29443 | Serotransferrin OS=Bos taurus OX=9913 GN=TF PE=2 SV=1 | 343.183 | 74 | 48 | 1709 | 46 | 704 | 77.7 | stress response;transport;other biological processes | non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle | other molecular function | 280705 | TF | bta:280705; Q0IIK2; Q29443 | 0.615274986253429 | 0.964709887217926 | 0.600414647182016 | 0.571407162236119 | 0.902231721267411 | 0.105569810421019 | 0.506704636011438 | 0.313748671859839 | 1.71679936327392E8 | 1.91001417946965E8 | 8.41149187199369E7 | 1.24867801818358E8 | 1.55146358811954E8 | 1.88178132242021E8 | 2.69795837029218E8 | 2.21755859229163E8 | 2.04768415701638E8 | 1.81082969779594E8 | 1.61167381210782E8 | 1.45463022007429E8 | 9.18433757916485E7 | 1.38609619584445E8 | 1.76572700073531E8 | |||
| P99027 | Large ribosomal subunit protein P2 [OS=Mus musculus] | 36.307 | 74 | 5 | 72 | 5 | 115 | 11.6 | protein metabolism;other metabolic processes | cytosol;translational apparatus;other cell component | other molecular function | 67186 | ENSMUSG00000025508 | Rplp2 | mmu:67186; P99027; Q3TKY3; Q9CQ99; Q9CZJ8 | Cytoplasmic ribosomal proteins | L13a-mediated translational silencing of Ceruloplasmin expression; SRP-dependent cotranslational protein targeting to membrane; Major pathway of rRNA processing in the nucleolus and cytosol; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.946568086066385 | 0.802315371714662 | 0.903936753250945 | 0.564848371108574 | 3399041.07520174 | 2851850.82913075 | 1601733.69914465 | 815551.673033217 | 867258.498357774 | 1625084.65937807 | 3955346.77360562 | 3509370.78947096 | 3554677.37975841 | 934269.224357541 | 392156.368890257 | 1254701.48751756 | |||
| Q9WVA4 | Transgelin-2 [OS=Mus musculus] | 49.237 | 71 | 12 | 144 | 10 | 199 | 22.4 | other biological processes | 21346 | ENSMUSG00000026547 | Tagln2 | mmu:21346; Q3TIB8; Q6A0C6; Q78ZX2; Q91VU2; Q9WVA4 | Platelet degranulation | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.940322254515829 | 0.994834213681465 | 0.85946611802464 | 0.399575694869052 | 3338415.96286452 | 2945418.24069324 | 1595032.39267318 | 1301091.15891193 | 1408632.10380685 | 2044292.87913917 | 6921646.04957812 | 5275332.74892481 | 3601520.96428178 | 1243484.77656065 | 738774.329736027 | 1658740.06520302 | ||||||
| P02463 | Collagen alpha-1(IV) chain [OS=Mus musculus] | 487.707 | 70 | 68 | 828 | 68 | 1669 | 160.6 | cell organization and biogenesis;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix | extracellular structural activity;other molecular function | 12826 | ENSMUSG00000031502 | Col4a1 | mmu:12826; P02463; Q3UHJ4; Q3UJE7; Q3UQV2; Q53X35; Q6GQS7; Q6PHB5; Q99LQ8 | Spinal cord injury; Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Laminin interactions; Signaling by PDGF; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions | 0.604225174343649 | 0.68008321917751 | 0.284160251285083 | 0.936818656936794 | 0.483508479481234 | 0.167300285011781 | 0.777395712279767 | 0.224623005929948 | 359769.877634713 | 285958.835932462 | 141085.539092917 | 2.00868956379824E7 | 2.17854047157598E7 | 2.25190928918174E7 | 4657081.16483192 | 4119739.1632835 | 5084724.84322114 | 3.91843343162395E7 | 3.69562703398771E7 | 2.33283395840594E7 | 7286914.931104 | 6193195.94075903 | 1.32557370999003E7 |
| Cont_P60712 | Actin, cytoplasmic 1 OS=Bos taurus OX=9913 GN=ACTB PE=1 SV=1 | 225.45 | 70 | 19 | 852 | 2 | 375 | 41.7 | cell organization and biogenesis;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component | enzyme regulator activity;cytoskeletal activity;other molecular function | 100033878; 100135470; 100173832; 101844587; 102139853; 11461; 118833809; 280979; 396526; 403580; 414396; 443052; 450133; 60; 81822 | ENSBTAG00000026199; ENSCAFG00000016020; ENSCAFG00030015381; ENSCAFG00040015695; ENSCPOG00000013467; ENSG00000075624; ENSMAUG00000008763; ENSMUSG00000029580; ENSOARG00040012985; ENSOARG00180022443; ENSOARG00185023855; ENSOARG00215030140; ENSOARG00225009314; ENSPPYG00000017336; ENSPTRG00000018890; ENSRNOG00000034254; ENSSSCG00000007585; ENSSSCG00030003451; ENSSSCG00035038792; ENSSSCG00040049462; ENSSSCG00045027458; ENSSSCG00050065025; ENSSSCG00055012597; ENSSSCG00060019124; ENSSSCG00065037921; ENSSSCG00070011353; ENSSSCG00105030144; ENSSSCG00110026965; ENSSSCG00115013637; ENSSSCG00130033784 | Actb; ACTB | A5D961; A5PKA1; bta:280979; cfa:403580; cpoc:100135470; csab:103246953; ecb:100033878; gga:396526; hsa:60; maua:101844587; mmu:11461; O18840; oas:443052; P02570; P60706; P60707; P60708; P60709; P60710; P60711; P60712; P60713; P70514; P99021; pon:100173832; ptr:450133; Q11209; Q11211; Q3SZD2; Q3TI89; Q3TVP6; Q4L0Y2; Q4R561; Q5R1X3; Q5R582; Q5R6G0; Q64316; Q6QAQ1; Q6ZWM3; Q711N9; Q71FK5; Q75MN2; Q76N69; Q8MIJ0; Q8SPX4; Q95164; Q96B34; Q96HG5; rno:81822; ssc:414396 | FAS pathway and stress induction of HSP regulation; Actin cytoskeleton regulation; Myometrial relaxation and contraction pathways; Focal adhesion; Arrhythmogenic right ventricular cardiomyopathy; Pathogenic Escherichia coli infection; Common pathways underlying drug addiction; Myometrial relaxation and contraction pathways; Focal adhesion; Fas ligand pathway and stress induction of heat shock proteins; Pathogenic Escherichia coli infection; Arrhythmogenic right ventricular cardiomyopathy; Focal adhesion; Myometrial relaxation and contraction pathways; Regulation of actin cytoskeleton; Myometrial relaxation and contraction pathways; Ebola virus infection in host; Acute viral myocarditis; Thermogenesis; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Overlap between signal transduction pathways contributing to LMNA laminopathies; Pleural mesothelioma; Regulation of actin cytoskeleton; Network map of SARS-CoV-2 signaling; Regulation of actin cytoskeleton; Regulation of actin cytoskeleton; Focal adhesion | Formation of the canonical BAF (cBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); Regulation of actin dynamics for phagocytic cup formation; EPH-ephrin mediated repulsion of cells; Formation of annular gap junctions; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; RHO GTPases Activate Formins; RHOF GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; B-WICH complex positively regulates rRNA expression; Regulation of CDH1 Function; Formation of the dystrophin-glycoprotein complex (DGC); Formation of the canonical BAF (cBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); RHO GTPases Activate WASPs and WAVEs; UCH proteinases; DNA Damage Recognition in GG-NER; Formation of the non-canonical BAF (ncBAF) complex; RHO GTPases activate IQGAPs; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Cell-extracellular matrix interactions; MAP2K and MAPK activation; Interaction between L1 and Ankyrins; RHOF GTPase cycle; DNA Damage Recognition in GG-NER; MAP2K and MAPK activation; RHO GTPases Activate Formins; Clathrin-mediated endocytosis; UCH proteinases; RHOF GTPase cycle; DNA Damage Recognition in GG-NER; EPH-ephrin mediated repulsion of cells; VEGFA-VEGFR2 Pathway; Regulation of actin dynamics for phagocytic cup formation; Adherens junctions interactions; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); RHO GTPases Activate WASPs and WAVEs; B-WICH complex positively regulates rRNA expression; Regulation of CDH1 Function; EPHB-mediated forward signaling; Formation of the non-canonical BAF (ncBAF) complex; Formation of the canonical BAF (cBAF) complex; Formation of annular gap junctions; RHO GTPases activate IQGAPs; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; RHO GTPases Activate WASPs and WAVEs; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RHO GTPases activate IQGAPs; RHO GTPases Activate Formins; RHOF GTPase cycle; Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs); B-WICH complex positively regulates rRNA expression; Signaling by BRAF and RAF1 fusions; UCH proteinases; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; VEGFA-VEGFR2 Pathway; Formation of the dystrophin-glycoprotein complex (DGC); Factors involved in megakaryocyte development and platelet production; Regulation of MITF-M-dependent genes involved in pigmentation; Formation of the canonical BAF (cBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); EPH-ephrin mediated repulsion of cells; HATs acetylate histones; Interaction between L1 and Ankyrins; Prefoldin mediated transfer of substrate to CCT/TriC; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Adherens junctions interactions; Regulation of CDH1 Function; Formation of the non-canonical BAF (ncBAF) complex; DNA Damage Recognition in GG-NER; Formation of the polybromo-BAF (pBAF) complex; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Formation of annular gap junctions; Folding of actin by CCT/TriC; Cell-extracellular matrix interactions; MAP2K and MAPK activation; RHO GTPases Activate Formins; Recycling pathway of L1; RHO GTPases activate IQGAPs; Clathrin-mediated endocytosis; Formation of the dystrophin-glycoprotein complex (DGC); EPHB-mediated forward signaling; UCH proteinases; B-WICH complex positively regulates rRNA expression; Adherens junctions interactions; Formation of the non-canonical BAF (ncBAF) complex; Formation of annular gap junctions; Formation of the polybromo-BAF (pBAF) complex; VEGFA-VEGFR2 Pathway; Cell-extracellular matrix interactions; RHO GTPases Activate WASPs and WAVEs; Regulation of CDH1 Function; Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; UCH proteinases; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); Formation of the polybromo-BAF (pBAF) complex; B-WICH complex positively regulates rRNA expression; DNA Damage Recognition in GG-NER; Formation of the canonical BAF (cBAF) complex; RHO GTPases Activate Formins; Regulation of CDH1 Function; Interaction between L1 and Ankyrins; RHOF GTPase cycle; Formation of the non-canonical BAF (ncBAF) complex; Adherens junctions interactions; Formation of the dystrophin-glycoprotein complex (DGC); VEGFA-VEGFR2 Pathway; RHO GTPases Activate WASPs and WAVEs; Cell-extracellular matrix interactions; EPHB-mediated forward signaling; MAP2K and MAPK activation; Recycling pathway of L1; RHO GTPases activate IQGAPs; Formation of annular gap junctions; B-WICH complex positively regulates rRNA expression; UCH proteinases; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); MAP2K and MAPK activation; Formation of the polybromo-BAF (pBAF) complex; RHO GTPases Activate Formins; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases Activate WASPs and WAVEs; Formation of the dystrophin-glycoprotein complex (DGC); VEGFA-VEGFR2 Pathway; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; DNA Damage Recognition in GG-NER; RHOF GTPase cycle; Cell-extracellular matrix interactions; Adherens junctions interactions; Formation of the non-canonical BAF (ncBAF) complex; Formation of the canonical BAF (cBAF) complex; RHO GTPases activate IQGAPs; Regulation of CDH1 Function; Gap junction degradation; Formation of annular gap junctions; Regulation of actin dynamics for phagocytic cup formation; RHOF GTPase cycle; Clathrin-mediated endocytosis; RHO GTPases Activate Formins; Cell-extracellular matrix interactions; VEGFA-VEGFR2 Pathway; Adherens junctions interactions; RHO GTPases activate IQGAPs; UCH proteinases; EPHB-mediated forward signaling; MAP2K and MAPK activation; RHO GTPases Activate WASPs and WAVEs; Formation of the dystrophin-glycoprotein complex (DGC); Formation of annular gap junctions; Formation of the canonical BAF (cBAF) complex; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of the non-canonical BAF (ncBAF) complex; Regulation of CDH1 Function | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.946568086066385 | 0.994348552930242 | 0.963278515868644 | 0.938282411159324 | 1924782.99006244 | 2098949.09709163 | 1966246.27612296 | 6.9333476629433E7 | 7.92679608662888E7 | 4.66219167617927E7 | 4.31411746831055E7 | 4.48147974340301E7 | 5.69102455002969E7 | 1.21577893646273E8 | 1.207324829685E8 | 8.72162161647777E7 | 5.58171302270344E7 | 3.75040107769213E7 | 6.67519874410893E7 |
| P63260 | Actin, cytoplasmic 2 [OS=Mus musculus] | 217.791 | 70 | 19 | 831 | 2 | 375 | 41.8 | cell organization and biogenesis;stress response;developmental processes;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 11465 | ENSMUSG00000062825 | Actg1 | mmu:11465; P02571; P14104; P63260; P99022 | Myometrial relaxation and contraction pathways; Regulation of actin cytoskeleton; Focal adhesion | Platelet degranulation ; RHO GTPases activate IQGAPs; Adherens junctions interactions; Regulation of CDH1 Function; RHO GTPases Activate Formins; Regulation of actin dynamics for phagocytic cup formation; Interaction between L1 and Ankyrins; MAP2K and MAPK activation; Recycling pathway of L1; Clathrin-mediated endocytosis; Formation of the dystrophin-glycoprotein complex (DGC); EPHB-mediated forward signaling; RHOF GTPase cycle; Formation of annular gap junctions; VEGFA-VEGFR2 Pathway; Cell-extracellular matrix interactions; RHO GTPases Activate WASPs and WAVEs; RHOBTB2 GTPase cycle | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.85271451854395 | 0.901789796153066 | 0.731487178650893 | 0.819844267712751 | 345218.530665522 | 243712.893345201 | 175067.879334021 | 138179.400499307 | 114235.784978709 | 184680.44906409 | 283414.957020267 | 357431.419092683 | 129167.257177683 | 191405.076269325 | 47386.9835565671 | 139954.449837086 | |||
| Cont_P35527 | Keratin, type I cytoskeletal 9 OS=Homo sapiens OX=9606 GN=KRT9 PE=1 SV=3 | 310.424 | 69 | 35 | 915 | 34 | 623 | 62 | cell organization and biogenesis;other biological processes | cytosol;cytoskeleton | cytoskeletal activity | 3857 | ENSG00000171403 | KRT9 | hsa:3857; O00109; P35527; Q0IJ47; Q14665 | Formation of the cornified envelope | 0.836660982916281 | 0.73072258897653 | 0.769556732848094 | 0.964570089320365 | 0.873609880131656 | 0.936669139837906 | 0.516448827835279 | 0.0110179641295352 | 3.00988862408693E7 | 2.22166955848562E7 | 3.53566605858277E7 | 3.83413938796298E7 | 4.01115354911529E7 | 4.55013850626263E7 | 3.25056930591839E7 | 3.99576081794461E7 | 2.50556157717982E7 | 4.79768166310243E7 | 2.93517742058567E7 | 7.69722436015544E7 | 1.31711700890849E8 | 9.27838604678364E7 | 5.6604390657593E7 | |
| Q91XV3 | Brain acid soluble protein 1 [OS=Mus musculus] | 84.613 | 69 | 9 | 121 | 9 | 226 | 22.1 | cell organization and biogenesis;developmental processes;other biological processes | plasma membrane;other membranes;nucleus;other cell component | nucleic acid binding activity;other molecular function | 70350 | ENSMUSG00000045763 | Basp1 | mmu:70350; Q91XV3 | RHOF GTPase cycle | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.850917681937748 | 0.865068878287396 | 0.948217415754165 | 0.849720620922415 | 1362011.11927008 | 1239340.97150253 | 1139072.73906572 | 564179.391534735 | 418599.607605535 | 582574.563182137 | 1108632.8864165 | 1270864.18619749 | 1068336.33315507 | 463559.386600798 | 382606.111084956 | 595292.168478121 | ||||
| Cont_P02081 | Hemoglobin fetal subunit beta OS=Bos taurus OX=9913 PE=1 SV=1 | 43.765 | 68 | 8 | 139 | 6 | 145 | 15.8 | other metabolic processes;transport;other biological processes | cytosol;other cell component | other molecular function | 0.364531904426892 | 0.2358261286618 | 0.463293082086092 | 0.328798481418023 | 0.950181954292864 | 0.881605220380855 | 0.937453377971347 | 0.622880861621114 | 9422687.49258887 | 6719727.86898196 | 5803890.24825753 | 4330686.53493356 | 6069450.23888522 | 4560292.30446579 | 4208206.42375347 | 4999214.25928966 | 4980503.25605162 | 6267204.81532326 | 7274768.41367181 | 5310722.09413616 | 4854825.1254444 | 3672226.77101208 | 8140551.6958571 | ||||||
| Q64433 | 10 kDa heat shock protein, mitochondrial [OS=Mus musculus] | 22.229 | 68 | 7 | 79 | 7 | 102 | 11 | protein metabolism;other metabolic processes | mitochondrion | other molecular function | 15528 | ENSMUSG00000073676 | Hspe1 | mmu:15528; Q64433 | RHOG GTPase cycle | 0.0917887729959558 | 0.0985125100188838 | 1.50457038391225E-17 | 0.1367389692144 | 0.87421335771164 | 0.871988363152002 | 0.856588419539538 | 0.875615554962516 | 20207.2996090432 | 1795033.79531347 | 1607088.74701353 | 1185753.77744954 | 1208151.89897442 | 865168.617058511 | 1523660.54306772 | 4432959.24831459 | 3210911.86048977 | 2832747.94626442 | 1942010.17282691 | 1242096.25679038 | 2024337.60877693 | |||
| P62259 | 14-3-3 protein epsilon [OS=Mus musculus] | 93.019 | 67 | 15 | 341 | 12 | 255 | 29.2 | stress response;developmental processes;signal transduction;other biological processes | plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component | enzyme regulator activity;other molecular function | 22627 | ENSMUSG00000020849 | Ywhae | mmu:22627; P29360; P42655; P62259; Q63631 | Myometrial relaxation and contraction pathways; Alpha 6 beta 4 integrin signaling pathway; Calcium regulation in cardiac cells | Regulation of HSF1-mediated heat shock response; RAB GEFs exchange GTP for GDP on RABs; Anchoring of the basal body to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; AURKA Activation by TPX2; TP53 Regulates Metabolic Genes; Activation of BAD and translocation to mitochondria ; RHO GTPases activate PKNs; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; NADE modulates death signalling; HSF1 activation; Signaling by Hippo | 1.65082956259427E-17 | 0.0173918608014292 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.953971000771159 | 0.98558531112136 | 0.961808375473893 | 0.883926343986088 | 17484.8546140728 | 10297.8320593379 | 6972319.65330627 | 5321697.90530677 | 5559653.43929525 | 3693380.77710522 | 2883022.50548721 | 4603672.2345604 | 1.25121635794151E7 | 1.06282269423704E7 | 6851231.05274656 | 3265608.73363903 | 3608346.70770129 | 4009646.14865423 | |
| P63242 | Eukaryotic translation initiation factor 5A-1 [OS=Mus musculus] | 44.4 | 67 | 8 | 104 | 8 | 154 | 16.8 | protein metabolism;other metabolic processes;signal transduction;other biological processes | other membranes;ER/Golgi;nucleus;other cell component | translation activity;nucleic acid binding activity;other molecular function | 276770 | ENSMUSG00000078812 | Eif5a | mmu:276770; P10159; P63242; Q16182; Q5NCX0; Q78NR3; Q9D0G2 | Translation factors | Hypusine synthesis from eIF5A-lysine | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.946568086066385 | 0.904392641853656 | 0.707919361302678 | 0.339769890517243 | 32548.1388735909 | 12070.9754086567 | 14199.4978081733 | 4056489.1475094 | 3818571.6736153 | 3350040.06754225 | 1712110.43069843 | 1306518.98956364 | 2541344.4118 | 6518632.70704459 | 4599568.23171138 | 3986162.98822878 | 1376510.71105031 | 627604.7215701 | 1555010.40646564 |
| Q9DAS9 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [OS=Mus musculus] | 12.396 | 67 | 4 | 25 | 4 | 72 | 8 | signal transduction | plasma membrane;other membranes;other cell component | other molecular function | 14701 | ENSMUSG00000036402 | Gng12 | mmu:14701; Q544P3; Q9DAS9 | Chemokine signaling pathway; G protein signaling pathways; Focal adhesion: PI3K-Akt-mTOR signaling pathway; Myometrial relaxation and contraction pathways; Regulation of actin cytoskeleton; Comprehensive IL-17A signaling; Calcium regulation in cardiac cells | GPER1 signaling; G alpha (i) signalling events; G alpha (q) signalling events; G alpha (12/13) signalling events; Ca2+ pathway; G beta:gamma signalling through PLC beta; Presynaptic function of Kainate receptors; ADP signalling through P2Y purinoceptor 12; Adrenaline,noradrenaline inhibits insulin secretion; Extra-nuclear estrogen signaling; G alpha (s) signalling events; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Vasopressin regulates renal water homeostasis via Aquaporins; Thromboxane signalling through TP receptor; High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells; Thrombin signalling through proteinase activated receptors (PARs); G-protein activation; Glucagon-type ligand receptors; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; G alpha (z) signalling events; G beta:gamma signalling through CDC42; Activation of G protein gated Potassium channels; Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits; ADP signalling through P2Y purinoceptor 1; G beta:gamma signalling through PI3Kgamma; Prostacyclin signalling through prostacyclin receptor; G beta:gamma signalling through BTK | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.657172914271921 | 0.946089070010067 | 0.199089132024186 | 0.600286749244923 | 150301.328499015 | 145925.433353311 | 126571.081453404 | 98299.5154117686 | 73601.0426250543 | 100630.198416078 | 540680.918983182 | 520505.154777131 | 397389.57923426 | 293399.407536829 | 243101.117339139 | 346427.369861065 | |||
| P05064 | Fructose-bisphosphate aldolase A [OS=Mus musculus] | 112.015 | 66 | 18 | 261 | 18 | 364 | 39.3 | cell organization and biogenesis;other metabolic processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | other molecular function | 11674 | ENSMUSG00000030695 | Aldoa | mmu:11674; P05064 | Glycolysis and gluconeogenesis | Platelet degranulation ; Neutrophil degranulation; Gluconeogenesis; Glycolysis | 0.101571037453114 | 0.00616383846364181 | 1.50457038391225E-17 | 0.0771819601934254 | 0.907383519445145 | 0.828577692034317 | 0.988377544628277 | 0.953305976192702 | 36553.7681309936 | 18014.3910425567 | 11156.0078725057 | 5538849.24179232 | 5285372.3367409 | 3856062.26656154 | 4263443.39983126 | 3386915.16711964 | 5306808.16889341 | 1.24814165546298E7 | 1.09515793948855E7 | 8528808.13475854 | 4192052.54158905 | 4075248.71161469 | 5289067.55868911 |
| P63101 | 14-3-3 protein zeta/delta [OS=Mus musculus] | 85.805 | 66 | 15 | 289 | 10 | 245 | 27.8 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | cytosol;nucleus;other cell component | other molecular function | 22631 | ENSMUSG00000022285 | Ywhaz | mmu:22631; P35215; P63101; P70197; P97286; Q3TSF1; Q5EBQ1 | IL-5 signaling pathway; IL-3 signaling pathway; Myometrial relaxation and contraction pathways; Alpha 6 beta 4 integrin signaling pathway; Calcium regulation in cardiac cells | TP53 Regulates Metabolic Genes; Activation of BAD and translocation to mitochondria ; RHO GTPases activate PKNs; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Rap1 signalling; GP1b-IX-V activation signalling; Interleukin-3, Interleukin-5 and GM-CSF signaling; Deactivation of the beta-catenin transactivating complex; Regulation of localization of FOXO transcription factors; NOTCH4 Activation and Transmission of Signal to the Nucleus; KSRP (KHSRP) binds and destabilizes mRNA | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.873755746039336 | 0.951563041423324 | 0.93482524409719 | 0.834163773575342 | 69535.8255809738 | 78847.9582112583 | 121989.790212482 | 1.07849176812864E7 | 9528517.79491501 | 8611576.97108304 | 5842325.28248147 | 4318908.58658828 | 7802439.53918656 | 2.58328839558383E7 | 1.99446241396289E7 | 1.50672257583468E7 | 6273918.76396034 | 5788855.71917891 | 8261103.25502296 |
| P18760 | Cofilin-1 [OS=Mus musculus] | 45.438 | 66 | 11 | 115 | 9 | 166 | 18.5 | cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;other molecular function | 12631 | ENSMUSG00000056201 | Cfl1 | mmu:12631; P18760 | G13 signaling pathway; Regulation of actin cytoskeleton | 0.346629783740056 | 0.26014877424013 | 0.362534518179133 | 0.412112821448938 | 0.945784131099142 | 0.931377691493433 | 0.870511801558508 | 0.647305095960454 | 4493954.17011393 | 5680138.4933051 | 6595908.45258571 | 1.11742389075122E7 | 1.01176598053604E7 | 8215200.73172656 | 8508248.77221218 | 8522369.80126875 | 1.02216677753501E7 | 1.73872199360457E7 | 1.6027940160356E7 | 1.45862421226393E7 | 1.08058843528415E7 | 1.054037483293E7 | 7896767.12653757 | |
| Cont_P04264 | Keratin, type II cytoskeletal 1 OS=Homo sapiens OX=9606 GN=KRT1 PE=1 SV=6 | 306.58 | 65 | 45 | 1774 | 36 | 644 | 66 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;other molecular function | 3848 | ENSG00000167768 | KRT1 | B2RA01; hsa:3848; P04264; P85925; P86104; Q14720; Q6GSJ0; Q9H298 | Corticotropin-releasing hormone signaling | Formation of the cornified envelope; Neutrophil degranulation; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.65780924735352 | 0.653826967689551 | 0.631165145316661 | 0.89629386854896 | 0.873609880131656 | 0.770634810212039 | 0.254077056479593 | 5.78940441291519E-5 | 1.31038801811221E8 | 1.49848314576813E8 | 1.81048519054156E8 | 1.64179912336924E8 | 1.70861004616453E8 | 1.60803236136221E8 | 1.32005397364365E8 | 1.61355773356369E8 | 1.09071204525108E8 | 1.84835731298625E8 | 1.38277867637903E8 | 2.0582953187505E8 | 6.47574942932283E8 | 3.95085049343759E8 | 3.00261678765842E8 |
| P15532 | Nucleoside diphosphate kinase A [OS=Mus musculus] | 49.516 | 64 | 9 | 178 | 5 | 152 | 17.2 | DNA metabolism;other metabolic processes;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle | translation activity;kinase activity;other molecular function | 18102 | ENSMUSG00000037601 | Nme1 | mmu:18102; P15532 | Purine metabolism | Azathioprine ADME; Interconversion of nucleotide di- and triphosphates; Ribavirin ADME | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.801576044337039 | 0.696358249006924 | 0.901149690306505 | 0.779071785728112 | 9564.24332396852 | 9206.73320544476 | 3592.15162523004 | 1.23866008536714E7 | 1.67366102660244E7 | 1.816742187365E7 | 5355631.14226611 | 4397707.11715414 | 6010321.56949385 | 1.35828724863268E7 | 1.6112953410397E7 | 1.16190055374183E7 | 3932460.71076704 | 2871882.80172497 | 7369907.5842535 |
| P10107 | Annexin A1 [OS=Mus musculus] | 115.566 | 64 | 18 | 270 | 18 | 346 | 38.7 | cell organization and biogenesis;stress response;transport;signal transduction;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component | enzyme regulator activity;other molecular function | 16952 | ENSMUSG00000024659 | Anxa1 | mmu:16952; P10107 | Spinal cord injury; Prostaglandin synthesis and regulation | G alpha (q) signalling events; G alpha (i) signalling events; Formyl peptide receptors bind formyl peptides and many other ligands | 1.65082956259427E-17 | 0.105053536950499 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.954328834404239 | 0.401885831342676 | 0.529099828181544 | 0.924766494197286 | 13280.9290610842 | 9160.53166722029 | 4508.77124840677 | 5251880.61554565 | 6740833.31198439 | 6058745.6526555 | 1560362.01883491 | 1521121.84391776 | 1946127.08618424 | 1.11990207127477E7 | 1.0990927807692E7 | 1.0321301103113E7 | 4605609.45936174 | 3223846.7434476 | 4805492.80063037 |
| Q3U962 | Collagen alpha-2(V) chain [OS=Mus musculus] | 518.514 | 64 | 57 | 817 | 55 | 1497 | 144.9 | cell organization and biogenesis;developmental processes;other biological processes | extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12832 | ENSMUSG00000026042 | Col5a2 | mmu:12832; Q3TVR2; Q3U962; Q3UHK7; Q3UTT4; Q3V1J6; Q61431; Q7TMS0; Q80VS8 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions | 0.861384746267066 | 0.961254912149485 | 0.730324052254867 | 0.632833892117728 | 0.0769666553885184 | 0.273444295895674 | 0.453486790198347 | 0.973358018692255 | 1.96082795853326E7 | 1.89754303457921E7 | 3.46758133166589E7 | 4.80275081428664E7 | 4.79991185130461E7 | 4.1747532446715E7 | 1.59204573672189E7 | 1.42782577106181E7 | 1.7061559679881E7 | 2.09575588581227E7 | 1.96948053072084E7 | 2.25862916575107E7 | 1.85137908486988E7 | 4881772.8383399 | 8018525.34642114 |
| P08122 | Collagen alpha-2(IV) chain [OS=Mus musculus] | 526.992 | 64 | 69 | 1077 | 69 | 1707 | 167.2 | RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix | extracellular structural activity | 12827 | ENSMUSG00000031503 | Col4a2 | mmu:12827; P08122; Q3B7C2; Q3TPV9; Q61375; Q66JS5; Q6RCT6; Q6RCT7; Q6U9X1; Q8BPI9; Q8BPK3; Q91VI3 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Focal adhesion | Laminin interactions; Signaling by PDGF; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions | 0.352816378116182 | 0.64759425713406 | 0.293387877727491 | 0.79866917976589 | 0.979628232635575 | 0.169673447599406 | 0.959159975702413 | 0.483015668880262 | 1499335.01530309 | 1691518.00623855 | 989751.415380184 | 5.53234274481973E7 | 5.88619201086468E7 | 3.63990683013196E7 | 1.35123643610626E7 | 1.30555597235297E7 | 1.53773176128868E7 | 6.80333035906639E7 | 6.55922447276284E7 | 4.55601360762201E7 | 1.71661195678148E7 | 9511844.25395737 | 2.43703078917008E7 |
| P08249 | Malate dehydrogenase, mitochondrial [OS=Mus musculus] | 76.52 | 64 | 17 | 185 | 17 | 338 | 35.6 | other metabolic processes | other membranes;mitochondrion | other molecular function | 17448 | ENSMUSG00000019179 | Mdh2 | mmu:17448; P08249; Q0QF44; Q8CF79; Q8R1P0 | Glycolysis and gluconeogenesis; TCA cycle | Mitochondrial protein degradation; Malate-aspartate shuttle; Citric acid cycle (TCA cycle) | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.946568086066385 | 0.795351011232032 | 0.379439362130093 | 0.0519452794981305 | 15464.3826212503 | 41218.8123977993 | 6349.06926840786 | 3539646.6249237 | 3439712.11067782 | 2814392.06783249 | 3214494.75039729 | 2177262.93413243 | 3118681.72885292 | 7068478.91480128 | 5414526.35847602 | 4605836.97916447 | 6275446.95884941 | 6149628.28208542 | 9656924.11001301 |
| P08121 | Collagen alpha-1(III) chain [OS=Mus musculus] | 695.631 | 63 | 61 | 1789 | 51 | 1464 | 138.9 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | extracellular matrix;other cell component | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 12825 | ENSMUSG00000026043 | Col3a1 | mmu:12825; P08121; Q61429; Q9CRN7 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Focal adhesion | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ECM proteoglycans; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; MET activates PTK2 signaling | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.00738207855214502 | 0.0413994480640273 | 0.394949139624895 | 0.976852696203657 | 619884.023482232 | 468692.52789102 | 275667.802679115 | 2.79020579584843E8 | 2.94236692581693E8 | 2.78582579285209E8 | 6.51340156000414E7 | 5.70632610319163E7 | 6.62894421161806E7 | 7.54516142044654E7 | 7.68700494785543E7 | 4.61499837269909E7 | 3.06665885804687E7 | 2.39448217703501E7 | 3.64849658219652E7 |
| P52927 | High mobility group protein HMGI-C [OS=Mus musculus] | 19.622 | 63 | 5 | 43 | 5 | 108 | 11.8 | cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | nucleus;other cell component | nucleic acid binding activity;other molecular function | 15364 | ENSMUSG00000056758 | Hmga2 | mmu:15364; P52927; Q3UQW0 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.779252881438118 | 0.56053198781818 | 0.336702291109547 | 0.130664835099106 | 319954.83032442 | 228777.540302378 | 227411.510007685 | 210264.647740795 | 238951.569339871 | 404743.063551681 | 993413.11105102 | 1070598.00165884 | 566537.703626656 | 681235.668365901 | 503102.248100656 | 826044.051259612 | ||||
| P17751 | Triosephosphate isomerase [OS=Mus musculus] | 49.057 | 63 | 12 | 145 | 12 | 249 | 26.7 | other metabolic processes | cytosol | other molecular function | 21991 | ENSMUSG00000023456 | Tpi1 | mmu:21991; P17751; Q3TJH2; Q3UC04; Q3UKG9; Q64513; Q9CVF9; Q9CWE7 | Fatty acid beta-oxidation; Glycolysis and gluconeogenesis | Gluconeogenesis; Glycolysis | 0.0806427656599262 | 0.0121257194234237 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.610019857175667 | 0.532399788858771 | 0.846117085258013 | 0.809503222445875 | 330816.658862061 | 509303.277190766 | 400581.208312955 | 2508200.21157107 | 1998539.96335636 | 2721175.10923974 | 2618512.04520777 | 1862714.96134193 | 2874979.35734375 | 9029946.93210895 | 6954894.5267767 | 6427613.76163295 | 3388942.90495023 | 3999204.03805736 | 4434675.15278015 |
| Cont_O46375 | Transthyretin OS=Bos taurus OX=9913 GN=TTR PE=1 SV=1 | 35.213 | 63 | 7 | 98 | 7 | 147 | 15.7 | other metabolic processes;signal transduction;other biological processes | non-structural extracellular | signal transduction activity or receptor binding;other molecular function | 280948 | ENSBTAG00000010991 | TTR | bta:280948; O46375; Q3SZ91 | Neutrophil degranulation; Retinoid metabolism and transport; The canonical retinoid cycle in rods (twilight vision) | 0.58171944587441 | 0.896787359697595 | 0.574380214123189 | 0.576573242661179 | 0.916283277860523 | 0.0154647678374212 | 0.313140733327643 | 0.338074799536125 | 9546693.56190286 | 1.31659005974371E7 | 8271040.97558915 | 1.0282617559534E7 | 8811959.22872725 | 1.34298684901053E7 | 2.33822192979533E7 | 2.03955874392209E7 | 1.95900458967146E7 | 1.51636766521962E7 | 1.10702472254716E7 | 9218071.15197036 | 9047123.1136248 | 9463495.33216257 | 1.05766898507312E7 | |
| Q99JI6 | Ras-related protein Rap-1b [OS=Mus musculus] | 34.031 | 63 | 9 | 84 | 9 | 184 | 20.8 | cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes | plasma membrane;other membranes;cytosol;other cell component | other molecular function | 215449 | ENSMUSG00000052681 | Rap1b | mmu:215449; Q99JI6 | Hepatocyte growth factor receptor signaling; Chemokine signaling pathway; Mapk signaling pathway; Na/K-ATPase/Src signaling; Integrin-mediated cell adhesion; Focal adhesion | Neutrophil degranulation; MAP2K and MAPK activation; Rap1 signalling; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; MET activates RAP1 and RAC1 | 0.615680953989958 | 0.845600701749816 | 0.579692877619887 | 0.703309497027447 | 0.813030657334935 | 0.983440558239231 | 0.50594120050135 | 0.812870015922388 | 10521.6032333623 | 20982.0939148299 | 1092792.61030233 | 1286954.41529451 | 1073121.26216853 | 685677.086956002 | 629242.737523905 | 828003.063254737 | 3931213.88716949 | 4067842.17788272 | 3944532.62829308 | 1482906.17334546 | 1080868.43495369 | 2268763.45821949 | |
| Cont_P00761 | Trypsin OS=Sus scrofa OX=9823 PE=1 SV=1 | 143.502 | 62 | 11 | 3859 | 10 | 231 | 24.4 | protein metabolism;other biological processes | non-structural extracellular | other molecular function | 0.254996071775817 | 0.172153475402034 | 0.357784551188889 | 0.34040294575649 | 0.822223648478518 | 0.740968241512781 | 0.960577895552113 | 0.148582186670595 | 5.17896971017178E9 | 5.13317471139103E9 | 7.27761160813741E9 | 2.70973552724487E9 | 1.73168232498425E9 | 2.0962236592694E9 | 3.08554430734093E9 | 3.85764460784296E9 | 3.06099934235171E9 | 1.42194297351806E9 | 1.8379662886425E9 | 3.81973460995747E9 | 5.23567407489624E9 | 5.3849654871275E9 | 2.81761370832162E9 | ||||||
| P14211 | Calreticulin [OS=Mus musculus] | 105.08 | 62 | 19 | 243 | 19 | 416 | 48 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;translational apparatus;nucleus;other cytoplasmic organelle;other cell component | signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function | 12317 | ENSMUSG00000003814 | Calr | mmu:12317; P14211; Q3TVD2 | Calcium regulation in cardiac cells | ER-Phagosome pathway; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Scavenging by Class A Receptors; Calnexin/calreticulin cycle | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.856884647332879 | 0.901056551888415 | 0.709416436039367 | 0.760027306440323 | 29010.1939176752 | 40438.9309766897 | 56470.2669367122 | 4146080.31907687 | 4788676.67235988 | 5620505.55686668 | 3731745.00016397 | 2573778.11690823 | 3727019.18482242 | 1.21431346024505E7 | 1.15652178398548E7 | 9027657.01145943 | 5278986.79529507 | 4694569.07998204 | 7831692.37354126 |
| Cont_Q3SZ57 | Alpha-fetoprotein OS=Bos taurus OX=9913 GN=AFP PE=2 SV=1 | 202.89 | 62 | 30 | 1153 | 29 | 610 | 68.5 | other metabolic processes;developmental processes;other biological processes | non-structural extracellular;other cell component | other molecular function | 506011 | ENSBTAG00000017131 | AFP | bta:506011; Q3SZ57 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 0.540832988168188 | 0.82964085881652 | 0.605387748357992 | 0.553772240900005 | 0.938859506774495 | 0.15729598575093 | 0.699570390946254 | 0.323545662226049 | 4.4629857016799E7 | 4.39639700572647E7 | 2.72178105183923E7 | 3.15168703669999E7 | 4.26075077823651E7 | 3.4328683389093E7 | 4.8541823037709E7 | 4.32960721364381E7 | 4.4115949306695E7 | 4.61564880446121E7 | 4.7548077639711E7 | 3.504265434565E7 | 2.7823391939759E7 | 3.01476017178829E7 | 5.24042356620578E7 | |
| Cont_P13645 | Keratin, type I cytoskeletal 10 OS=Homo sapiens OX=9606 GN=KRT10 PE=1 SV=6 | 286.713 | 62 | 30 | 1322 | 20 | 584 | 58.8 | cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes | plasma membrane;cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;other molecular function | 3858 | ENSG00000186395 | KRT10 | hsa:3858; P13645; Q14664; Q8N175 | Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.600890052902075 | 0.490821286240141 | 0.561934876627864 | 0.941696908693733 | 0.829734761131295 | 0.880940844456856 | 0.246231694954624 | 2.55433624902191E-5 | 8.57039306780817E7 | 1.2308209015436E8 | 1.23973335952419E8 | 1.09050331614224E8 | 1.30109606828786E8 | 1.02692161896587E8 | 8.73473050095944E7 | 1.23031831133367E8 | 7.19147674496861E7 | 1.29238189237995E8 | 9.43248217623685E7 | 1.03859326412487E8 | 5.11249836753994E8 | 2.4676744393623E8 | 2.01230291385254E8 | |
| P52480 | Pyruvate kinase PKM [OS=Mus musculus] | 163.393 | 62 | 27 | 442 | 27 | 531 | 57.8 | cell organization and biogenesis;other metabolic processes;other biological processes | cytosol;ER/Golgi;nucleus;other cell component | nucleic acid binding activity;kinase activity;other molecular function | 18746 | ENSMUSG00000032294 | Pkm | mmu:18746; P52480; Q3TBV8; Q3TBW5; Q3TC59; Q3U1X3; Q3U5P6; Q4VC20; Q64484; Q91YI8; Q9CWB1 | Glycolysis and gluconeogenesis; Purine metabolism | Neutrophil degranulation; Pyruvate metabolism; Glycolysis; Regulation of pyruvate metabolism | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.938859506774495 | 0.972868731003358 | 0.958705855138011 | 0.959522188921769 | 312569.127047718 | 79336.1029165598 | 280190.614862653 | 2.13357824001936E7 | 1.96436562290884E7 | 9081648.29120601 | 1.01259485831113E7 | 9467201.29798786 | 1.55257573035923E7 | 3.31547939620584E7 | 3.43565739025104E7 | 2.75852274417617E7 | 1.43901632993649E7 | 7722776.69094361 | 1.86748082798887E7 |
| P62908 | Small ribosomal subunit protein uS3 [OS=Mus musculus] | 44.876 | 61 | 14 | 146 | 14 | 243 | 26.7 | cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;translational apparatus;nucleus;other cell component | cytoskeletal activity;nucleic acid binding activity;other molecular function | 27050 | ENSMUSG00000030744 | Rps3 | mmu:27050; P17073; P47933; P62908 | Cytoplasmic ribosomal proteins | L13a-mediated translational silencing of Ceruloplasmin expression; SRP-dependent cotranslational protein targeting to membrane; Major pathway of rRNA processing in the nucleolus and cytosol; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition | 0.199859183640187 | 0.0204712693531403 | 1.50457038391225E-17 | 0.2282690138179 | 0.889322773294568 | 0.897374575947205 | 0.975873825035145 | 0.995207197530012 | 13392.2908067534 | 6664.84075995145 | 1396037.07035745 | 2096906.85456819 | 1354441.63195124 | 925606.130163894 | 926400.763318311 | 1496046.97044967 | 3684898.52106675 | 3802906.30171756 | 3176874.23464465 | 1308497.13417903 | 770444.702508235 | 1786633.97095349 | |
| P17742 | Peptidyl-prolyl cis-trans isomerase A [OS=Mus musculus] | 113.527 | 60 | 9 | 369 | 9 | 164 | 18 | cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes | non-structural extracellular;cytosol;nucleus;other cell component | signal transduction activity or receptor binding;other molecular function | 268373 | ENSMUSG00000071866 | Ppia | mmu:268373; P17742; Q9CWJ5; Q9R137 | Neutrophil degranulation; Basigin interactions | 0.100219677394751 | 0.099382125133403 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.946239447314336 | 0.696358249006924 | 0.937453377971347 | 0.331144967260478 | 1.16891341386391E7 | 754837.409863468 | 4157779.88062054 | 2.9189343463191E7 | 2.94929696895869E7 | 4.96473559496876E7 | 1.04342545713823E7 | 8178713.43858634 | 1.18234267071803E7 | 4.91534751033825E7 | 4.2865019365108E7 | 4.61937263356195E7 | 9682919.1999608 | 7275434.18699702 | 1.51319991253865E7 | |
| P20152 | Vimentin [OS=Mus musculus] | 183.446 | 60 | 29 | 762 | 27 | 466 | 53.7 | cell organization and biogenesis;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component | cytoskeletal activity;nucleic acid binding activity;other molecular function | 22352 | ENSMUSG00000026728 | Vim | mmu:22352; O08704; P20152; Q8CCH1 | Spinal cord injury; Primary focal segmental glomerulosclerosis (FSGS); Alpha 6 beta 4 integrin signaling pathway | Aggrephagy; Striated Muscle Contraction; Caspase-mediated cleavage of cytoskeletal proteins; RHOBTB1 GTPase cycle | 1.65082956259427E-17 | 0.0955146622024883 | 1.50457038391225E-17 | 0.137621774180062 | 0.873609880131656 | 0.0297998664849654 | 0.840672080806375 | 0.0332723373064956 | 573727.34417641 | 968981.536762911 | 1794707.43115169 | 4.14069582585024E7 | 3.33312643886138E7 | 2.54656192896882E7 | 6941733.99810384 | 6173483.46835617 | 8980531.63051753 | 8.80704815958352E7 | 8.07026224155391E7 | 5.51524218564722E7 | 1.5029979690535E7 | 6861556.37440952 | 1.68923991921504E7 |
| P48678 | Prelamin-A/C [OS=Mus musculus] | 202.607 | 60 | 37 | 529 | 36 | 665 | 74.2 | cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes | other membranes;cytoskeleton;nucleus;other cell component | other molecular function | 16905 | ENSMUSG00000028063 | Lmna | B3RH23; B3RH24; mmu:16905; P11516; P48678; P97859; Q3TIH0; Q3TTS8; Q3U733; Q3U7I5; Q3UCA0; Q3UCJ8; Q3UCU3; Q91WF2; Q9DC21 | Adipogenesis genes; FAS pathway and stress induction of HSP regulation | 1.65082956259427E-17 | 0.00670345592293191 | 0.139423967594304 | 1.70336894001643E-17 | 0.236076921565588 | 0.77212820363828 | 0.901149690306505 | 0.00692305873191716 | 56886.7483713492 | 69336.1384695612 | 100943.444664856 | 1.29312831685903E7 | 1.22006597313063E7 | 8045013.512583 | 3337288.2268023 | 3262868.75019265 | 5804803.63611667 | 6.75536277126862E7 | 5.59333072922179E7 | 3.75993669940438E7 | 7422846.33935557 | 4234323.21548912 | 7210898.93259597 | |
| P17182 | Alpha-enolase [OS=Mus musculus] | 126.804 | 60 | 19 | 244 | 16 | 434 | 47.1 | other metabolic processes;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;other cell component | nucleic acid binding activity;other molecular function | 13806; 433182 | ENSMUSG00000059040; ENSMUSG00000063524 | Eno1 | mmu:13806; mmu:433182; P17182; Q99KT7; Q9DCY7 | Glycolysis and gluconeogenesis | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.720832939248489 | 0.789540446904924 | 0.858218537342417 | 0.989544231571828 | 31098.019126098 | 70318.9502605952 | 40658.6319347469 | 1.28655809626545E7 | 1.34726279447959E7 | 7101469.5445256 | 9089751.86845938 | 7552189.93174957 | 1.17772011823713E7 | 3.50544676757808E7 | 2.99447661492486E7 | 2.18255690502528E7 | 1.30151947674988E7 | 1.11532480577619E7 | 1.75489228796712E7 | |
| Q9CQV8 | 14-3-3 protein beta/alpha [OS=Mus musculus] | 64.301 | 59 | 13 | 263 | 6 | 246 | 28.1 | other biological processes | cytosol;nucleus;other cell component | enzyme regulator activity;other molecular function | 54401 | ENSMUSG00000018326 | Ywhab | mmu:54401; O70455; Q3TY33; Q3UAN6; Q9CQV8 | IL-3 signaling pathway; Myometrial relaxation and contraction pathways; Alpha 6 beta 4 integrin signaling pathway; Calcium regulation in cardiac cells; EGFR1 signaling pathway | RAF activation; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; MAP2K and MAPK activation; Negative regulation of MAPK pathway; Rap1 signalling; TP53 Regulates Metabolic Genes; mTORC1-mediated signalling; Activation of BAD and translocation to mitochondria ; RHO GTPases activate PKNs; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Regulation of localization of FOXO transcription factors; Frs2-mediated activation; Signaling by Hippo | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.349255191559715 | 0.764791307960872 | 0.937453377971347 | 0.506626554334227 | 827509.480689047 | 665625.54503926 | 484962.959916708 | 352602.166539251 | 290574.29293556 | 554603.529270735 | 3354582.04090562 | 2429479.578985 | 1791950.60044087 | 552088.916805761 | 620253.16794601 | 851553.2990227 | |||
| P11276 | Fibronectin [OS=Mus musculus] | 867.353 | 58 | 95 | 2246 | 59 | 2477 | 272.4 | cell adhesion;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi | signal transduction activity or receptor binding;enzyme regulator activity;other molecular function | 14268 | ENSMUSG00000026193 | Fn1 | G5E8B8; mmu:14268; P11276; Q61567; Q61568; Q61569; Q64233; Q80UI4 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Inflammatory response pathway; Regulation of actin cytoskeleton; Comprehensive IL-17A signaling; Focal adhesion | ECM proteoglycans; Platelet degranulation ; Cell surface interactions at the vascular wall; Syndecan interactions; MAP2K and MAPK activation; Integrin cell surface interactions; Molecules associated with elastic fibres; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Fibronectin matrix formation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; Degradation of the extracellular matrix; Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells; MET activates PTK2 signaling; GPER1 signaling | 0.0844744457809114 | 0.00584906503121538 | 1.50457038391225E-17 | 0.156115961659409 | 0.974036928885484 | 0.564710097967506 | 0.435823028559966 | 0.896613838854506 | 3.10111960161575E7 | 2.79853612635427E7 | 2.39278028537136E7 | 2.27076161669542E8 | 2.29530848002383E8 | 1.81481696567249E8 | 2.13523563015262E8 | 1.92386583493888E8 | 2.00792310651879E8 | 3.0604731494329E8 | 2.72875123758133E8 | 2.45952285820886E8 | 1.1928889459527E8 | 1.00071254189999E8 | 1.59531432686856E8 |
| P57780 | Alpha-actinin-4 [OS=Mus musculus] | 239.42 | 58 | 45 | 483 | 30 | 912 | 104.9 | cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes | cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 60595 | ENSMUSG00000054808 | Actn4 | mmu:60595; P57780 | Primary focal segmental glomerulosclerosis (FSGS) | Platelet degranulation | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 0.19149089837131 | 0.921882153462399 | 0.795351011232032 | 0.968364585136618 | 0.938282411159324 | 5221.79731213346 | 36578.541519335 | 9107610.67207618 | 1.00453975465233E7 | 1.03378326393571E7 | 5095419.11923033 | 3409382.50707632 | 5238186.41277381 | 1.31020350186557E7 | 1.2711162036506E7 | 9162046.18669404 | 4501757.36231035 | 3002316.05426355 | 5816939.08777499 | |
| Cont_P02533 | Keratin, type I cytoskeletal 14 OS=Homo sapiens OX=9606 GN=KRT14 PE=1 SV=4 | 164.831 | 58 | 26 | 684 | 9 | 472 | 51.5 | cell organization and biogenesis;other biological processes | plasma membrane;cytosol;cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 3861 | ENSG00000186847 | KRT14 | hsa:3861; P02533; Q14715; Q53XY3; Q9BUE3; Q9UBN2; Q9UBN3; Q9UCY4 | Corticotropin-releasing hormone signaling | Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin; Developmental Lineage of Mammary Gland Myoepithelial Cells; Type I hemidesmosome assembly | 0.821333803243143 | 0.880930298968675 | 0.666244110962191 | 0.887279041944908 | 0.735573385767802 | 0.728871118050286 | 0.645534074006669 | 1.76226512549596E-4 | 6033554.14310828 | 6671959.15781397 | 7782964.06135275 | 8837829.92566611 | 1.15627425945257E7 | 9278023.72116937 | 1.41062299354562E7 | 8950994.20838312 | 7841743.81261716 | 1.15454726530467E7 | 7260451.91646668 | 9574113.2223773 | 5.39893889957522E7 | 2.05703168301172E7 | 1.34402077310531E7 |
| P51150 | Ras-related protein Rab-7a [OS=Mus musculus] | 37.713 | 58 | 10 | 86 | 10 | 207 | 23.5 | cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes | other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component | other molecular function | 19349 | ENSMUSG00000079477 | Rab7a | mmu:19349; P51150 | Neutrophil degranulation; TBC/RABGAPs; RAB geranylgeranylation; MHC class II antigen presentation; RAB GEFs exchange GTP for GDP on RABs; RAC1 GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; RHOH GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOF GTPase cycle; RHOD GTPase cycle | 0.636939170495467 | 0.655487072215252 | 0.329609069656752 | 0.341991892565807 | 0.833071794079159 | 0.98558531112136 | 0.651065339556331 | 0.988640647886026 | 42971.6509871291 | 5091.39156563082 | 639760.02594531 | 739162.65348356 | 500483.334399648 | 222359.681018454 | 184373.14165851 | 370823.666713167 | 1735951.05761641 | 1620414.31808119 | 1328466.83726779 | 643161.73478289 | 519980.624428654 | 811733.26317896 | ||
| P61982 | 14-3-3 protein gamma [OS=Mus musculus] | 60.158 | 58 | 13 | 257 | 7 | 247 | 28.3 | stress response;other biological processes | cytosol;mitochondrion;nucleus;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;other molecular function | 22628 | ENSMUSG00000051391 | Ywhag | mmu:22628; O70457; P35214; P61982; Q3UFD6; Q4FK44; Q9UDP2; Q9UN99 | Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells | Regulation of PLK1 Activity at G2/M Transition; Anchoring of the basal body to the plasma membrane; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; AURKA Activation by TPX2; TP53 Regulates Metabolic Genes; Activation of BAD and translocation to mitochondria ; RHO GTPases activate PKNs; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Regulation of localization of FOXO transcription factors | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.916283277860523 | 0.962211568833812 | 0.977491813528386 | 0.819844267712751 | 11156.8721315139 | 36200.581767039 | 23387.4360494223 | 4210658.69388125 | 3208586.17889202 | 3661156.3629375 | 2204630.70190343 | 1697092.38093418 | 2907466.79306312 | 1.01883087621914E7 | 7383913.05140651 | 5871207.54485329 | 2178767.01595034 | 2340848.33881766 | 2680750.92991385 |
| Cont_P15497 | Apolipoprotein A-I OS=Bos taurus OX=9913 GN=APOA1 PE=1 SV=3 | 75.831 | 58 | 15 | 290 | 15 | 265 | 30.3 | cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes | non-structural extracellular | transporter activity;enzyme regulator activity;other molecular function | 281631 | APOA1 | A5D7M9; bta:281631; P15497; Q3SZD9 | Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Chylomicron assembly; Chylomicron remodeling; HDL remodeling; Retinoid metabolism and transport; HDL clearance; HDL assembly; Heme signaling; Scavenging by Class B Receptors | 0.65780924735352 | 0.31171894348249 | 0.726427194598544 | 0.535702081245677 | 0.946568086066385 | 0.941920360687835 | 0.809490543293719 | 0.822877979404198 | 2.21263225838005E7 | 1.78450644532212E7 | 1.97796498018408E7 | 1.78787447784222E7 | 2.53238412660337E7 | 2.49900782473361E7 | 1.22627903702188E7 | 1.43058080986995E7 | 1.29755953410419E7 | 2.9020982567081E7 | 2.93612230403275E7 | 2.70148520622022E7 | 1.43730714643769E7 | 1.13015329009906E7 | 2.71801121001229E7 | ||
| P0DP27 | Calmodulin-2 [OS=Mus musculus] | 62.362 | 57 | 9 | 169 | 9 | 149 | 16.8 | cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cell component | signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function | 12314; 12315 | ENSMUSG00000001175; ENSMUSG00000019370; ENSMUSG00000036438 | Calm2 | mmu:12313; mmu:12314; mmu:12315; P02593; P0DP27; P62204; P70667; P99014; Q3TEH7; Q3THK5; Q3U6Z5; Q3U7C7; Q498A3; Q61379; Q61380; Q8BNC9; Q91VQ9; Q9D6G4 | Alzheimer's disease; Glycogen metabolism; Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.984287101108728 | 0.776236845683195 | 0.735963266366428 | 0.938345185723697 | 9269.40267105667 | 18119.1865278059 | 4478912.44611262 | 4086961.29294744 | 4541929.19146932 | 1934024.88060433 | 1698621.68217392 | 2127186.45800379 | 6815126.06503849 | 7660172.12932354 | 6531268.56798019 | 3730259.02064885 | 2678903.48416191 | 4079256.80015976 | ||
| P07356 | Annexin A2 [OS=Mus musculus] | 93.779 | 57 | 19 | 258 | 19 | 339 | 38.7 | cell adhesion;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component | enzyme regulator activity;cytoskeletal activity;other molecular function | 12306 | ENSMUSG00000032231 | Anxa2 | mmu:12306; P07356 | Prostaglandin synthesis and regulation | Neutrophil degranulation; Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells; Dissolution of Fibrin Clot | 1.65082956259427E-17 | 0.0270399871803413 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.709229396391097 | 0.79692396389698 | 0.261357540418382 | 0.992207061422946 | 80913.0723608937 | 91932.8000229824 | 159834.257411985 | 8809993.14550338 | 1.20868855954933E7 | 1.24351534037538E7 | 5139070.9377241 | 4323306.53315277 | 5989807.68314801 | 3.18682696567451E7 | 3.28596309408812E7 | 2.58712263649755E7 | 1.49101863447254E7 | 1.21319314583051E7 | 1.7708905346053E7 |
| P35700 | Peroxiredoxin-1 [OS=Mus musculus] | 37.928 | 57 | 10 | 157 | 8 | 199 | 22.2 | cell cycle OR cell proliferation;other metabolic processes;stress response;signal transduction;other biological processes | cytosol;nucleus;other cell component | other molecular function | 18477 | ENSMUSG00000028691 | Prdx1 | mmu:18477; P35700; Q3UBV4; Q9CWI2 | Oxidative stress and redox pathway | TP53 Regulates Metabolic Genes; Detoxification of Reactive Oxygen Species; NFE2L2 regulating anti-oxidant/detoxification enzymes | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.971110042775673 | 0.696358249006924 | 0.609490560578387 | 0.971151633247904 | 28013.3390039087 | 10513.3151242123 | 6837119.7949797 | 6183018.26261091 | 3863278.95114693 | 4753006.47365099 | 4035477.11586219 | 6451102.62207213 | 8386206.05847774 | 8171820.06897361 | 5665108.45486536 | 3203316.06079976 | 2771774.56679962 | 3952127.57034216 | |
| P09411 | Phosphoglycerate kinase 1 [OS=Mus musculus] | 116.462 | 57 | 18 | 287 | 18 | 417 | 44.5 | protein metabolism;other metabolic processes;stress response;other biological processes | non-structural extracellular;other membranes;cytosol;mitochondrion;other cell component | kinase activity;other molecular function | 18655 | ENSMUSG00000062070 | Pgk1 | mmu:18655; P09411; Q3TPE6; Q3UKV8; Q5XJE7 | Glycolysis and gluconeogenesis | Gluconeogenesis; Glycolysis | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.465126095372736 | 0.766862952867809 | 0.820281310709571 | 0.891044455497809 | 78089.4641074341 | 38741.0917691314 | 23421.0514741904 | 4316274.39280249 | 5023293.68471847 | 1442874.888393 | 2829873.33459098 | 2934698.045784 | 3868274.47312523 | 1.65254946701665E7 | 1.56270051770472E7 | 1.22346365889796E7 | 4530199.20599689 | 2315853.03926933 | 6654180.61411261 |
| P33434 | 72 kDa type IV collagenase [OS=Mus musculus] | 212.03 | 56 | 30 | 889 | 30 | 662 | 74.1 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes | extracellular matrix;plasma membrane;other membranes;cytoskeleton;mitochondrion;nucleus;other cell component | other molecular function | 17390 | ENSMUSG00000031740 | Mmp2 | mmu:17390; P33434 | Lung fibrosis; IL-3 signaling pathway; Matrix metalloproteinases | Collagen degradation; Extra-nuclear estrogen signaling; EPH-ephrin mediated repulsion of cells; Activation of Matrix Metalloproteinases | 0.372996577396536 | 0.964209443670126 | 0.342075680986172 | 0.708142491896103 | 0.993994198406889 | 0.459747209584207 | 0.34519376377552 | 0.809503222445875 | 1.45817945044039E7 | 3.99854546791863E7 | 2.31586213408419E7 | 6.16168347215595E7 | 6.71128653428481E7 | 5.47627512450794E7 | 2.153095933586E7 | 2.04088973517033E7 | 2.1514079157928E7 | 9.59427020238632E7 | 8.49468673692442E7 | 8.11217362792938E7 | 5.65046943814106E7 | 3.5725700482165E7 | 6.85636819548367E7 |
| P26645 | Myristoylated alanine-rich C-kinase substrate [OS=Mus musculus] | 102.649 | 56 | 9 | 183 | 9 | 309 | 29.6 | cell organization and biogenesis;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component | cytoskeletal activity;other molecular function | 17118 | ENSMUSG00000069662 | Marcks | mmu:17118; P26645 | Acetylcholine regulates insulin secretion | 0.686762258673 | 0.868732914228523 | 0.429932681715422 | 0.675450317413542 | 0.854305439376382 | 0.86315143463057 | 0.557354230551857 | 0.960067393782086 | 42980.3388156882 | 41898.6161386359 | 41525.7349435975 | 1443906.20707304 | 1714465.16128686 | 1542596.23448158 | 536168.318695651 | 523262.393588195 | 852705.514569508 | 4438527.05710504 | 4375638.80151598 | 3114301.65618414 | 1532659.00136844 | 1122453.03544494 | 1644505.61194952 | |
| P29391 | Ferritin light chain 1 [OS=Mus musculus] | 41.989 | 56 | 7 | 45 | 7 | 183 | 20.8 | transport;other biological processes | non-structural extracellular;other cytoplasmic organelle;other cell component | other molecular function | Ftl1 | P29391; Q8WUQ8 | 0.470628233842304 | 0.916949047389333 | 0.436404735539909 | 0.838430822182208 | 0.984023681099692 | 0.594847259878045 | 0.840672080806375 | 0.286865690112685 | 11250.950061026 | 164363.787033117 | 96571.5430931945 | 117093.264494885 | 43219.3148133758 | 41008.0784847386 | 49942.1149094357 | 231062.388635405 | 217800.809192591 | 248463.651274961 | 22056.2158795235 | ||||||||
| Q00915 | Retinol-binding protein 1 [OS=Mus musculus] | 48.013 | 56 | 7 | 112 | 7 | 135 | 15.8 | other metabolic processes;other biological processes | cytosol;nucleus;other cell component | other molecular function | 19659 | ENSMUSG00000046402 | Rbp1 | mmu:19659; Q00915 | Retinol metabolism | Retinoid metabolism and transport; The canonical retinoid cycle in rods (twilight vision) | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.762176653003896 | 0.764791307960872 | 0.850760367544917 | 0.474848317785811 | 1866015.44814727 | 1690749.75742334 | 1346043.60114138 | 600896.849096756 | 543423.979559132 | 1233445.01773539 | 4815413.61167082 | 4593886.64533296 | 3422364.46967646 | 894694.26199539 | 744604.388112891 | 1536347.73518956 | |||
| P27773 | Protein disulfide-isomerase A3 [OS=Mus musculus] | 115.891 | 55 | 23 | 291 | 23 | 505 | 56.6 | cell adhesion;cell organization and biogenesis;stress response;signal transduction;other biological processes | non-structural extracellular;other membranes;ER/Golgi;other cell component | nucleic acid binding activity;other molecular function | 14827 | ENSMUSG00000027248 | Pdia3 | mmu:14827; P27773; Q3TEI9; Q3TIL2; Q3UZK8; Q8C2F4; Q99LF6 | ER-Phagosome pathway; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Calnexin/calreticulin cycle | 0.9135584231482 | 0.736536116100563 | 0.498293621965442 | 0.874168055361729 | 0.850917681937748 | 0.862063111456553 | 0.881496352314601 | 0.939046770372612 | 206281.038958907 | 253939.7116523 | 128510.108086966 | 6669793.66068216 | 7133803.24141356 | 5637352.69437344 | 5319375.96186612 | 3844376.07822282 | 6321729.00885173 | 1.83298906806341E7 | 1.50101054148645E7 | 1.26051366299531E7 | 6670485.36185494 | 6059857.55300524 | 8984695.03809976 | |
| Cont_Q3MHN5 | Vitamin D-binding protein OS=Bos taurus OX=9913 GN=GC PE=2 SV=1 | 113.599 | 55 | 20 | 319 | 20 | 474 | 53.3 | other metabolic processes;transport | non-structural extracellular;other cell component | transporter activity;cytoskeletal activity;other molecular function | 530076 | GC | bta:530076; Q3MHN5 | 0.549057967251154 | 0.804331105646976 | 0.579435037816218 | 0.479472599858427 | 0.946173787415917 | 0.139718417146003 | 0.570795727084329 | 0.421365656927814 | 1.55879441314789E7 | 1.53074066841615E7 | 7458694.29508707 | 1.04365108192777E7 | 1.20620475306269E7 | 8309099.82300618 | 1.67215053413279E7 | 1.54231806136738E7 | 1.57780518794517E7 | 1.6556516146824E7 | 1.52311500265876E7 | 1.20681229464E7 | 8133055.93664235 | 9478628.98672491 | 1.47438110125204E7 | |||
| P31786 | Acyl-CoA-binding protein [OS=Mus musculus] | 14.554 | 55 | 3 | 25 | 3 | 87 | 10 | other metabolic processes;stress response;developmental processes;other biological processes | non-structural extracellular;ER/Golgi | other molecular function | 13167 | ENSMUSG00000026385 | Dbi | mmu:13167; P31786 | PPAR signaling pathway | Mitochondrial Fatty Acid Beta-Oxidation | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.927458364365403 | 0.815208287206116 | 0.570795727084329 | 0.579328739210792 | 307456.870510134 | 372967.502828048 | 466246.230022766 | 205366.44219537 | 138939.514670588 | 212068.293185609 | 460651.499495821 | 517145.077763924 | 572958.93647871 | 99167.9909364818 | 109813.402160245 | 130980.248883021 | |||
| O08709 | Peroxiredoxin-6 [OS=Mus musculus] | 58.137 | 55 | 11 | 118 | 11 | 224 | 24.9 | cell organization and biogenesis;other metabolic processes;stress response;other biological processes | cytosol;other cytoplasmic organelle | other molecular function | 11758 | Prdx6 | mmu:11758; O08709; Q91WT2; Q9QWP4; Q9QWW0 | Neutrophil degranulation; Detoxification of Reactive Oxygen Species | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.912218866069753 | 0.98558531112136 | 0.866315173576397 | 0.958852965333904 | 1634804.34803319 | 1706671.96318366 | 462379.005285331 | 814979.975671148 | 650045.663219344 | 990585.013572245 | 3486272.66785309 | 3240204.32262637 | 2629774.04644166 | 1287444.576733 | 356862.065430393 | 1648957.81286328 | |||||
| Q61598 | Rab GDP dissociation inhibitor beta [OS=Mus musculus] | 90.105 | 55 | 19 | 207 | 15 | 445 | 50.5 | transport;signal transduction;other biological processes | other membranes;ER/Golgi;other cell component | enzyme regulator activity;other molecular function | 14569 | ENSMUSG00000021218 | Gdi2 | mmu:14569; Q541Z9; Q61598; Q8C530; Q9D8M9 | Neutrophil degranulation; RAB GEFs exchange GTP for GDP on RABs | 1.65082956259427E-17 | 0.0445586736872124 | 1.50457038391225E-17 | 0.12230616593894 | 0.957324015670425 | 0.696358249006924 | 0.947056398526689 | 0.891044455497809 | 7568.30103587639 | 2613166.41142051 | 2980669.16495025 | 3507823.89455971 | 1018070.34575623 | 727946.612092406 | 1353313.10952308 | 4351511.80036085 | 4094060.40698043 | 4061464.64033076 | 1257652.94808244 | 945188.523481553 | 1812216.8966664 | |||
| O09131 | Glutathione S-transferase omega-1 [OS=Mus musculus] | 32.337 | 55 | 12 | 134 | 12 | 240 | 27.5 | other metabolic processes;signal transduction;other biological processes | cytosol;other cell component | other molecular function | 14873 | ENSMUSG00000025068 | Gsto1 | mmu:14873; O09131; Q3TH87 | Metapathway biotransformation; Myometrial relaxation and contraction pathways; Oxidative stress and redox pathway | Glutathione conjugation; Methylation; Vitamin C (ascorbate) metabolism | 0.828088839920889 | 0.868732914228523 | 0.827536988704287 | 0.921569528792101 | 0.829930391195847 | 0.972868731003358 | 0.850760367544917 | 0.91523518908434 | 1.16523031330507E7 | 4485678.96181783 | 5228918.91172617 | 7429111.17402723 | 5364569.45791218 | 6154543.21131111 | 3951080.24175672 | 3499039.00524432 | 4879673.6485662 | 5704724.74672471 | 5308450.19876887 | 5090643.61787655 | 6211709.08335403 | 3610503.83521333 | 3381654.01076559 |
| P35979 | Large ribosomal subunit protein uL11 [OS=Mus musculus] | 29.639 | 55 | 6 | 64 | 6 | 165 | 17.8 | protein metabolism;other metabolic processes | cytosol;translational apparatus;nucleus;other cell component | nucleic acid binding activity;other molecular function | 269261 | ENSMUSG00000038900 | Rpl12 | mmu:269261; P35979; Q9CQK4 | Cytoplasmic ribosomal proteins; mRNA processing | L13a-mediated translational silencing of Ceruloplasmin expression; SRP-dependent cotranslational protein targeting to membrane; Major pathway of rRNA processing in the nucleolus and cytosol; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 1.65082956259427E-17 | 0.012106576537997 | 1.50457038391225E-17 | 0.113740476677079 | 0.990459928977729 | 0.904392641853656 | 0.968364585136618 | 0.859280013525435 | 13586.9255483391 | 723027.615040525 | 816717.155861558 | 427127.222666935 | 340773.547868048 | 360118.474082686 | 535619.345441155 | 1082129.54307879 | 1209755.68190013 | 1070036.12405551 | 389436.649395538 | 304672.729853011 | 588482.35090214 | ||
| Q61599 | Rho GDP-dissociation inhibitor 2 [OS=Mus musculus] | 30.236 | 55 | 7 | 55 | 7 | 200 | 22.8 | signal transduction;other biological processes | cytosol | enzyme regulator activity;other molecular function | 11857 | ENSMUSG00000030220 | Arhgdib | mmu:11857; Q3TEB3; Q61599 | G13 signaling pathway; FAS pathway and stress induction of HSP regulation | RAC1 GTPase cycle; RAC3 GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RHOG GTPase cycle; RHOH GTPase cycle | 0.896523374675327 | 0.964709887217926 | 0.730324052254867 | 0.890289034593217 | 0.944154202827561 | 0.821250089830506 | 0.92723844956096 | 0.0935491991990551 | 32474.5706791495 | 14325.7245980277 | 440880.074294265 | 319533.924051821 | 554500.105293745 | 101227.692210764 | 79857.2367890125 | 180726.341626593 | 999410.084626213 | 533736.514746238 | 860743.749144492 | 85660.7954451718 | 51909.6934486661 | 122196.080730475 | |
| Q6IRU2 | Tropomyosin alpha-4 chain [OS=Mus musculus] | 57.649 | 54 | 14 | 181 | 13 | 248 | 28.5 | other biological processes | cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 326618 | ENSMUSG00000031799 | Tpm4 | mmu:326618; Q6IRU2 | Striated Muscle Contraction; RHOV GTPase cycle; Smooth Muscle Contraction | 1.65082956259427E-17 | 0.0604891281086189 | 1.50457038391225E-17 | 0.277029822654878 | 0.950643439691574 | 0.475270298946442 | 0.995103281526289 | 0.769722729696518 | 48169.0765970921 | 91422.0645346332 | 101278.05213091 | 7976648.59092772 | 8281478.09635796 | 7637503.87327968 | 2730566.6024022 | 1705684.35053161 | 4078690.74622792 | 1.16856488939063E7 | 1.14353238001446E7 | 8644589.28738447 | 3435042.86921096 | 1968023.76809684 | 4478416.48668098 | |
| P47931 | Follistatin [OS=Mus musculus] | 72.636 | 54 | 13 | 179 | 13 | 344 | 37.8 | cell cycle OR cell proliferation;developmental processes;signal transduction;other biological processes | nucleus;other cell component | signal transduction activity or receptor binding;other molecular function | 14313 | ENSMUSG00000021765 | Fst | A6H6P0; mmu:14313; P47931 | TGF-beta signaling pathway | Antagonism of Activin by Follistatin | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.912218866069753 | 0.950675859937599 | 0.679036846514028 | 0.849720620922415 | 7272167.90433319 | 7396919.94462099 | 6499969.62532323 | 4381221.5370214 | 4385282.70515593 | 5249526.88162253 | 8741151.05479083 | 8226871.39816201 | 5331222.84220915 | 2367848.30342728 | 715525.145319083 | 3901425.58057529 | |||
| Cont_P08779 | Keratin, type I cytoskeletal 16 OS=Homo sapiens OX=9606 GN=KRT16 PE=1 SV=4 | 140.751 | 54 | 25 | 569 | 12 | 473 | 51.2 | cell organization and biogenesis;stress response;other biological processes | plasma membrane;cytosol;cytoskeleton | cytoskeletal activity | 3868 | ENSG00000186832 | KRT16 | A8K488; hsa:3868; P08779; P30654; Q16402; Q9UBG8 | Vitamin D receptor pathway | Formation of the cornified envelope | 0.941324060398065 | 0.961351301268194 | 0.761460393544015 | 0.887279041944908 | 0.82543231800733 | 0.493923182294169 | 0.895302208460818 | 3.1065941501805E-4 | 1047544.82178002 | 1389728.97312405 | 1389730.63830375 | 1501449.09449526 | 2307427.01338473 | 2939547.44501319 | 7196685.12946156 | 1715910.61220057 | 2812173.28112121 | 4331979.12309994 | 1639569.64130669 | 1737373.70058763 | 9547147.41410007 | 4434008.92515372 | 2223613.02167429 |
| P47879 | Insulin-like growth factor-binding protein 4 [OS=Mus musculus] | 76.974 | 54 | 10 | 179 | 10 | 254 | 27.8 | cell cycle OR cell proliferation;signal transduction;other biological processes | non-structural extracellular | other molecular function | 16010 | ENSMUSG00000017493 | Igfbp4 | mmu:16010; O35666; P47879; Q3TMV0 | Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Myometrial relaxation and contraction pathways | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.194454617400155 | 0.797858239267722 | 0.384825651287801 | 0.925251017275216 | 598012.753056151 | 220890.166133709 | 808955.893414319 | 2.42668746185362E7 | 2.35661091910725E7 | 2.20103948370773E7 | 1.1489486634584E7 | 9395826.54401368 | 1.03414425178759E7 | 1.20544350527508E7 | 1.17426221200254E7 | 7571405.70789237 | 6120402.0499282 | 3657692.98865192 | 6280545.41029435 |
| P62897 | Cytochrome c, somatic [OS=Mus musculus] | 17.03 | 54 | 5 | 32 | 5 | 105 | 11.6 | other metabolic processes;signal transduction;other biological processes | cytosol;mitochondrion | other molecular function | 13063 | ENSMUSG00000058927; ENSMUSG00000063694 | Cycs | mmu:13063; P00009; P62897; Q8C2S2 | Oxidative damage response; p53 signaling; Parkinson's disease; Na/K-ATPase/Src signaling | TP53 Regulates Metabolic Genes; Respiratory electron transport; Cytoprotection by HMOX1; Detoxification of Reactive Oxygen Species; Release of apoptotic factors from the mitochondria; Pyroptosis; Activation of caspases through apoptosome-mediated cleavage; Regulation of the apoptosome activity; Transcriptional activation of mitochondrial biogenesis | 0.287918277254699 | 0.664079299483355 | 0.253564158652808 | 0.997751268638055 | 0.976873891151678 | 0.35166285974068 | 0.896866816139962 | 0.809503222445875 | 21078.0178036204 | 353781.78703588 | 469413.121746567 | 589668.591665022 | 164224.978576512 | 120926.022521668 | 153753.14547937 | 944247.135809769 | 845121.491133909 | 677710.338370425 | 158862.252050871 | 200320.300269668 | 301133.028713877 | ||
| Q7TPR4 | Alpha-actinin-1 [OS=Mus musculus] | 235.529 | 54 | 42 | 511 | 27 | 892 | 103 | cell adhesion;cell organization and biogenesis;other biological processes | plasma membrane;other membranes;cytoskeleton;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function | 109711 | ENSMUSG00000015143 | Actn1 | mmu:109711; Q7TPR4 | Regulation of actin cytoskeleton; Integrin-mediated cell adhesion; Focal adhesion | Platelet degranulation ; RHOF GTPase cycle; RHOBTB2 GTPase cycle; RHOD GTPase cycle; Regulation of cytoskeletal remodeling and cell spreading by IPP complex components | 0.995554138371554 | 0.178726136005694 | 0.819280225722906 | 0.941696908693733 | 0.974207409660283 | 0.744084716394381 | 0.837231569641376 | 0.879972045955715 | 354073.059499792 | 209249.076355465 | 897084.460899514 | 5526121.35104279 | 6211867.70337129 | 6893436.45630869 | 2413615.48536692 | 1933168.81934458 | 3229981.90899851 | 1.03807818109957E7 | 1.11771340173328E7 | 8282960.99949337 | 3416305.89125481 | 2797115.44078374 | 4939050.64701654 |
| Q9Z1Q5 | Chloride intracellular channel protein 1 [OS=Mus musculus] | 42.206 | 54 | 9 | 74 | 9 | 241 | 27 | transport;other biological processes | non-structural extracellular;plasma membrane;other membranes;mitochondrion;ER/Golgi;nucleus;other cell component | transporter activity;other molecular function | 114584 | ENSMUSG00000007041 | Clic1 | mmu:114584; Q9Z1Q5 | 0.469735153113543 | 0.665461902659705 | 0.393759312397256 | 0.647634649567584 | 0.873755746039336 | 0.45138210203261 | 0.421486031099999 | 0.769722729696518 | 21384.3285028392 | 18098.1480760882 | 282403.300686972 | 366245.338629701 | 327890.510802669 | 34676.5047667658 | 84831.4301508928 | 117692.733558477 | 782105.773253663 | 757861.516675744 | 756470.259317965 | 347753.783372261 | 142577.816442464 | 282666.053269447 | |||
| P68372 | Tubulin beta-4B chain [OS=Mus musculus] | 85.867 | 53 | 17 | 253 | 3 | 445 | 49.8 | cell organization and biogenesis;other biological processes | cytoskeleton;other cell component | cytoskeletal activity;nucleic acid binding activity;other molecular function | 227613 | ENSMUSG00000036752 | Tubb4b | mmu:227613; P05217; P68372; Q3TKF0; Q3UJ73; Q99JZ6 | Neutrophil degranulation; PKR-mediated signaling; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-independent Golgi-to-ER retrograde traffic; Hedgehog 'off' state; MHC class II antigen presentation; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; COPI-mediated anterograde transport; Separation of Sister Chromatids; Anchoring of the basal body to the plasma membrane; Resolution of Sister Chromatid Cohesion; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; RHO GTPases Activate Formins; AURKA Activation by TPX2; EML4 and NUDC in mitotic spindle formation; Intraflagellar transport; Carboxyterminal post-translational modifications of tubulin; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Recycling pathway of L1; RHO GTPases activate IQGAPs; The role of GTSE1 in G2/M progression after G2 checkpoint; Aggrephagy; Sealing of the nuclear envelope (NE) by ESCRT-III | 0.205801242418232 | 0.82964085881652 | 1.50457038391225E-17 | 0.126912128965224 | 0.898895014125291 | 0.915464852681021 | 0.709593139419252 | 0.953305976192702 | 2510.01980218531 | 3275114.04938016 | 2598821.51327027 | 1906519.60409322 | 1355554.11820818 | 1376215.81385627 | 1605138.68109294 | 6571183.44879001 | 5839187.09328728 | 4547155.57257512 | 2936550.69049437 | 1355995.13732086 | 2695608.39525063 | |||
| P57776 | Elongation factor 1-delta [OS=Mus musculus] | 62.183 | 53 | 12 | 114 | 11 | 281 | 31.3 | protein metabolism;other metabolic processes | nucleus;other cell component | nucleic acid binding activity;other molecular function | 66656 | Eef1d | mmu:66656; P57776; Q68FG5; Q9CWW2; Q9CWY1; Q9CYD4; Q9CYJ5 | Translation factors | Eukaryotic Translation Elongation | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.955415831169955 | 0.815208287206116 | 0.910644219048229 | 0.172162260281775 | 1660276.54796983 | 2618710.91323531 | 1110665.01652067 | 722609.995998999 | 708945.375547943 | 938859.400412804 | 4534487.91462717 | 3664812.25870665 | 3428916.91100971 | 700669.503793328 | 402637.691071844 | 977022.437052094 | ||||
| P63017 | Heat shock cognate 71 kDa protein [OS=Mus musculus] | 161.557 | 53 | 28 | 572 | 23 | 646 | 70.8 | cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component | signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function | 15481 | ENSMUSG00000015656 | Hspa8 | mmu:15481; P08109; P12225; P63017; Q3U6R0; Q3U764; Q3U7D7; Q3U7E2; Q3U9B4; Q3U9G0; Q3UGM0; Q5FWJ6; Q62373; Q62374; Q62375; Q6NZD0 | Mapk signaling pathway; Exercise-induced circadian regulation | Neutrophil degranulation; mRNA Splicing - Major Pathway; Regulation of HSF1-mediated heat shock response; PKR-mediated signaling; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis; Attenuation phase; Lysosome Vesicle Biogenesis; GABA synthesis, release, reuptake and degradation; AUF1 (hnRNP D0) binds and destabilizes mRNA; Protein methylation | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.987939278265184 | 0.953011140807089 | 0.709593139419252 | 0.587315224195015 | 247063.168316828 | 221267.865667273 | 228333.997143376 | 2.34302361722569E7 | 1.91610816116977E7 | 2.44529780700925E7 | 1.52458610795295E7 | 1.21057626921531E7 | 1.98188188374949E7 | 4.35786305197153E7 | 3.523488629513E7 | 2.44125225303247E7 | 1.30838270231471E7 | 9679200.3009757 | 1.32405397257932E7 |
| P01027 | Complement C3 [OS=Mus musculus] | 388.541 | 53 | 70 | 1148 | 62 | 1663 | 186.4 | cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular;other cell component | signal transduction activity or receptor binding;enzyme regulator activity | 12266 | ENSMUSG00000024164 | C3 | mmu:12266; P01027; Q61370; Q80XP1 | Complement activation, classical pathway; Tyrobp causal network in microglia; Comprehensive IL-17A signaling | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade; Neutrophil degranulation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; G alpha (i) signalling events; Peptide ligand-binding receptors; Alternative complement activation; Activation of C3 and C5 | 0.712660037675161 | 0.729783028721347 | 0.506101547380209 | 0.762068821001752 | 0.939492000987438 | 0.512232143465318 | 0.413470300505934 | 0.991722673088443 | 4040096.73815256 | 3926631.83282415 | 1843021.41157313 | 4.04154698805798E7 | 4.4896658832648E7 | 4.8335201547635E7 | 1.80671896153384E7 | 1.47828809765086E7 | 1.7121367805152E7 | 9.88883606977539E7 | 8.1974398309486E7 | 5.99376709525504E7 | 3.21393016835685E7 | 2.84159228355073E7 | 4.96444404075474E7 |
| Cont_Q7SIH1 | Alpha-2-macroglobulin OS=Bos taurus OX=9913 GN=A2M PE=1 SV=2 | 370.864 | 53 | 56 | 1089 | 56 | 1510 | 167.5 | non-structural extracellular | enzyme regulator activity;other molecular function | 513856 | ENSBTAG00000018137 | A2M | A8E647; bta:513856; Q7SIH1 | IL-6 signaling pathway | 0.688450665125024 | 0.839052280267302 | 0.731111241255251 | 0.509007335932165 | 0.944154202827561 | 0.540124873725708 | 0.671798309985569 | 0.809503222445875 | 5.71770657169572E7 | 6.35766951637367E7 | 4.19549690627817E7 | 6.46032237401637E7 | 7.37926671048822E7 | 7.2164410166051E7 | 8.06000315293491E7 | 7.23429494984619E7 | 7.40068576999505E7 | 8.7810317845685E7 | 9.50258669209954E7 | 6.46884849507494E7 | 4.10565401116459E7 | 3.96461495018234E7 | 7.63451634810678E7 | ||
| P68510 | 14-3-3 protein eta [OS=Mus musculus] | 64.921 | 53 | 12 | 224 | 7 | 246 | 28.2 | cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes | plasma membrane;other membranes;cytosol;mitochondrion;other cell component | cytoskeletal activity;other molecular function | 22629 | ENSMUSG00000018965 | Ywhah | mmu:22629; P11576; P68510; P70198; Q3TGZ9 | Myometrial relaxation and contraction pathways; Alpha 6 beta 4 integrin signaling pathway; Calcium regulation in cardiac cells | TP53 Regulates Metabolic Genes; Activation of BAD and translocation to mitochondria ; RHO GTPases activate PKNs; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.944154202827561 | 0.869908412860824 | 0.901149690306505 | 0.80954066750699 | 866773.880513068 | 694957.34543049 | 528233.86994798 | 459099.803564724 | 336630.897381686 | 625139.874551717 | 1680014.83549611 | 1370635.53518424 | 1070075.78560199 | 411442.579490808 | 389261.929304593 | 434172.721834376 | |||
| P68254 | 14-3-3 protein theta [OS=Mus musculus] | 62.581 | 53 | 12 | 235 | 6 | 245 | 27.8 | signal transduction;other biological processes | cytosol;nucleus;other cell component | other molecular function | 22630 | ENSMUSG00000076432 | Ywhaq | mmu:22630; P35216; P68254; Q3TW69; Q3UJN5; Q5SP76; Q5U423; Q66JR6 | Primary focal segmental glomerulosclerosis (FSGS); Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells | TP53 Regulates Metabolic Genes; Activation of BAD and translocation to mitochondria ; RHO GTPases activate PKNs; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Regulation of localization of FOXO transcription factors | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.829734761131295 | 0.987212456243842 | 0.947768687612402 | 0.111289914871169 | 811494.060532178 | 1160025.64990226 | 687138.145998916 | 323208.495396455 | 266808.020378426 | 588690.429375452 | 2790947.38639894 | 2126368.5130483 | 1602263.69915333 | 737300.291971803 | 488218.38641787 | 813808.362626944 | |||
| P10639 | Thioredoxin [OS=Mus musculus] | 23.642 | 52 | 4 | 72 | 4 | 105 | 11.7 | other metabolic processes;stress response;other biological processes | non-structural extracellular;cytosol;nucleus;other cell component | other molecular function | 22166 | ENSMUSG00000028367 | Txn | mmu:22166; P10639; Q52KC4; Q9D8R0 | Oxidative stress and redox pathway | TP53 Regulates Metabolic Genes; Interconversion of nucleotide di- and triphosphates; Detoxification of Reactive Oxygen Species; Oxidative Stress Induced Senescence; Protein repair; The NLRP3 inflammasome | 1.65082956259427E-17 | 0.00669448551858978 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.850917681937748 | 0.877818946381645 | 0.937453377971347 | 0.557162779351822 | 41188.8256347366 | 62810.4731690741 | 69722.3097873949 | 3963132.70276491 | 4250080.74892895 | 3277681.33381362 | 2070313.26068679 | 1605081.7083092 | 2257186.20178381 | 1.15144437335734E7 | 1.06031844207169E7 | 8311020.99510969 | 2469095.68758122 | 1725699.50911632 | 3517034.96471403 |
| Q01853 | Transitional endoplasmic reticulum ATPase [OS=Mus musculus] | 179.055 | 52 | 32 | 411 | 32 | 806 | 89.3 | cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;other biological processes | other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;enzyme regulator activity;other molecular function | 269523 | ENSMUSG00000028452 | Vcp | mmu:269523; Q01853; Q3TFH9; Q3TIM2; Q3TXN9; Q6PI18; Q8BSR6; Q8CEG4 | IL-9 signaling pathway | RHOH GTPase cycle; Neutrophil degranulation; Protein methylation; Ovarian tumor domain proteases; Neddylation; ABC-family proteins mediated transport; Translesion Synthesis by POLH; Hedgehog ligand biogenesis; KEAP1-NFE2L2 pathway; HSF1 activation; N-glycan trimming in the ER and Calnexin/Calreticulin cycle; Josephin domain DUBs | 0.915230778358139 | 0.645007535999596 | 0.808626104853287 | 0.953867932777128 | 0.953038161729767 | 0.877818946381645 | 0.901149690306505 | 0.737824045087029 | 462345.280919521 | 876653.458620268 | 526426.850526767 | 1.01571081063743E7 | 9889323.38925712 | 7942233.31155878 | 4702185.44070802 | 4580279.55870278 | 6732778.24078372 | 1.50535993864462E7 | 1.350776734351E7 | 9751498.62422888 | 4128956.06599177 | 3881002.94215154 | 5380991.32313934 |
| Q60605 | Myosin light polypeptide 6 [OS=Mus musculus] | 37.443 | 52 | 7 | 128 | 7 | 151 | 16.9 | other biological processes | cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 17904 | ENSMUSG00000090841 | Myl6 | mmu:17904; Q60605 | Focal adhesion | Smooth Muscle Contraction; RHO GTPases activate PAKs | 0.17954279960394 | 0.0597174367248522 | 0.201227492083465 | 0.11406862536513 | 0.974827674952665 | 0.877818946381645 | 0.969838013602216 | 0.901489646134689 | 11161.9883314762 | 44510.5971347212 | 2084535.0596028 | 2100098.50880368 | 1345595.20705123 | 1174902.84347918 | 991676.675961175 | 1551381.67808176 | 3464371.70742686 | 3457566.84497288 | 2726353.85272463 | 1564297.57799137 | 827028.966562118 | 1705156.18172858 | |
| P48036 | Annexin A5 [OS=Mus musculus] | 62.988 | 52 | 13 | 142 | 13 | 319 | 35.7 | stress response;other biological processes | non-structural extracellular;plasma membrane;other membranes | other molecular function | 11747 | ENSMUSG00000027712 | Anxa5 | mmu:11747; P48036; Q3U5Q1; Q3U5X4; Q3U8K1; Q3UGV0; Q99LA1 | Prostaglandin synthesis and regulation | Platelet degranulation | 0.962729299537276 | 0.964743998810065 | 0.649716058260961 | 0.826927610267147 | 0.934852211695135 | 0.993131538222517 | 0.85946611802464 | 0.941015048843842 | 132596.068853932 | 144295.425355019 | 72047.968900453 | 1566862.03559226 | 2586796.57910424 | 2492469.51394109 | 1494694.7163126 | 1254384.02027252 | 1254515.80206169 | 4847425.50967578 | 5026917.54031612 | 4160871.35356632 | 1581239.93399408 | 1845719.33352807 | 2646905.70386385 |
| P47955 | Large ribosomal subunit protein P1 [OS=Mus musculus] | 30.889 | 52 | 2 | 19 | 2 | 114 | 11.5 | protein metabolism;other metabolic processes;other biological processes | cytosol;translational apparatus;other cell component | other molecular function | 56040 | ENSMUSG00000007892 | Rplp1 | mmu:56040; P47955 | Cytoplasmic ribosomal proteins | L13a-mediated translational silencing of Ceruloplasmin expression; SRP-dependent cotranslational protein targeting to membrane; Major pathway of rRNA processing in the nucleolus and cytosol; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 1.65082956259427E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.850917681937748 | 5.07936507936508E-17 | 5.0092807424594E-17 | 0.0701816001240928 | 82669.4992701545 | 65144.4636720168 | 155926.075900288 | 292480.554672862 | 9052.36634659204 | |||||||||||
| Q9R0P5 | Destrin [OS=Mus musculus] | 37.385 | 52 | 9 | 95 | 8 | 165 | 18.5 | cell organization and biogenesis;other biological processes | cytoskeleton;other cell component | cytoskeletal activity | 56431 | ENSMUSG00000015932 | Dstn | mmu:56431; Q9R0P5 | 0.624017478365996 | 0.565681144660315 | 0.933133994208656 | 0.872856628412806 | 0.873755746039336 | 0.823375259461247 | 0.870511801558508 | 0.598108737233685 | 18629.9800934308 | 16103.0559745737 | 10491.4958491576 | 1084285.90835057 | 1052692.4849104 | 930814.809929399 | 441595.426509515 | 603047.113175247 | 1028865.739982 | 2709485.36834431 | 1870694.59731736 | 2153074.98222179 | 423599.428908783 | 551014.772778044 | 937220.476472916 | ||
| P62806 | Histone H4 [OS=Mus musculus] | 28.854 | 51 | 6 | 141 | 6 | 103 | 11.4 | cell organization and biogenesis;other biological processes | nucleus;other cell component | nucleic acid binding activity;other molecular function | 100041230; 319155; 319156; 319157; 319158; 319159; 319160; 319161; 320332; 326619; 326620; 69386; 97122 | ENSMUSG00000060093; ENSMUSG00000060639; ENSMUSG00000060678; ENSMUSG00000060981; ENSMUSG00000061482; ENSMUSG00000064288; ENSMUSG00000067455; ENSMUSG00000069266; ENSMUSG00000069274; ENSMUSG00000069305; ENSMUSG00000069306; ENSMUSG00000091405; ENSMUSG00000096010 | H4c1; H4c11; H4c12; H4c14; H4c16; H4c2; H4c3; H4c4; H4c6; H4c8; H4c9; Hist1h4m | A0AUM5; A4FUP8; A4QMY0; mmu:100041230; mmu:319155; mmu:319156; mmu:319157; mmu:319158; mmu:319159; mmu:319160; mmu:319161; mmu:320332; mmu:326619; mmu:326620; mmu:69386; mmu:97122; P02304; P02305; P62806; Q0VDL9; Q2M2Q5; Q5T006; Q6PDS7; Q811M0; Q9D0C9; Q9D6Q8 | Type II interferon signaling (IFNG) | RMTs methylate histone arginines; Regulation of endogenous retroelements by KRAB-ZFP proteins; SUMOylation of chromatin organization proteins; Recognition and association of DNA glycosylase with site containing an affected purine; Cleavage of the damaged purine; Condensation of Prophase Chromosomes; DNA Damage/Telomere Stress Induced Senescence; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Nonhomologous End-Joining (NHEJ); Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Inhibition of DNA recombination at telomere; PKMTs methylate histone lysines; Deposition of new CENPA-containing nucleosomes at the centromere; HDACs deacetylate histones; HATs acetylate histones; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Estrogen-dependent gene expression; PRC2 methylates histones and DNA; Negative Regulation of CDH1 Gene Transcription; MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis; HDMs demethylate histones | 0.418336752208667 | 0.94042169150467 | 1.50457038391225E-17 | 0.241544210438834 | 0.209371478859288 | 0.0543182519985559 | 3.35547127108615E-4 | 0.925789913630174 | 330396.220987003 | 352301.569568663 | 434120.452166522 | 1491132.80768763 | 2764739.76367265 | 2388107.47241261 | 444920.639624805 | 413584.046050742 | 428807.558440276 | 1.10244285236545E7 | 1.05125763785661E7 | 8104617.87119501 | 3832098.99177262 | 2274315.39690736 | 6138492.6632106 |
| P09528 | Ferritin heavy chain [OS=Mus musculus] | 35.812 | 51 | 8 | 107 | 8 | 182 | 21.1 | transport;other biological processes | non-structural extracellular;other membranes;cytosol;other cytoplasmic organelle;other cell component | other molecular function | 14319 | ENSMUSG00000024661 | Fth1 | mmu:14319; P09528; Q3UI44 | Iron homeostasis | Golgi Associated Vesicle Biogenesis; Neutrophil degranulation; Iron uptake and transport | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.36338274194713 | 0.90689241393859 | 0.941560341878142 | 0.0189080413265164 | 11415.1978386791 | 28293.3100342271 | 1453202.35191744 | 1665370.20752275 | 2136960.03887089 | 1094619.17678832 | 1071794.5819197 | 1209435.50405188 | 8429916.92726459 | 7005658.83506906 | 5770731.87743088 | 1166037.42857518 | 1124992.7984086 | 1227403.44254746 | |
| Cont_P13647 | Keratin, type II cytoskeletal 5 OS=Homo sapiens OX=9606 GN=KRT5 PE=1 SV=3 | 142.395 | 51 | 34 | 500 | 20 | 590 | 62.3 | cell organization and biogenesis;other biological processes | cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;cytoskeletal activity;other molecular function | 3852 | ENSG00000186081 | KRT5 | hsa:3852; P13647; Q6PI71; Q6UBJ0; Q8TA91 | Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin; Developmental Lineage of Mammary Stem Cells; Developmental Lineage of Mammary Gland Myoepithelial Cells; Type I hemidesmosome assembly | 0.786915923361782 | 0.847457711018997 | 0.707170943024881 | 0.746833150482801 | 0.873755746039336 | 0.714156118974909 | 0.2733017775894 | 2.49132633766938E-5 | 5120503.46953844 | 5171426.92187225 | 6553368.21772984 | 9669299.63907403 | 1.1127930529353E7 | 9127716.50969809 | 9513581.76230213 | 7584977.17814252 | 6506980.60696686 | 1.59683716443188E7 | 1.28154121523541E7 | 1.32126695164861E7 | 5.39600661696836E7 | 1.8678004759752E7 | 1.36191738010446E7 | |
| Q02819 | Nucleobindin-1 [OS=Mus musculus] | 131.152 | 51 | 21 | 299 | 21 | 459 | 53.4 | signal transduction | non-structural extracellular;other membranes;ER/Golgi | enzyme regulator activity;nucleic acid binding activity;other molecular function | 18220 | ENSMUSG00000030824 | Nucb1 | mmu:18220; Q02819; Q3TU42; Q9CWA1; Q9D8J4; Q9DBL3 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 0.130903496983571 | 0.0679830640731695 | 0.340647566778883 | 0.397987186613988 | 0.958122559708965 | 41072.7931792495 | 20198.6046706008 | 1.70846710933602E7 | 1.97547416617741E7 | 2.08807433533847E7 | 5757191.6972993 | 4828078.95450858 | 5895038.38978249 | 7136546.74332753 | 7387752.88718417 | 5120327.81590923 | 2637872.59598673 | 1130733.36645935 | 3369667.63744922 | ||
| P17918 | Proliferating cell nuclear antigen [OS=Mus musculus] | 50.145 | 51 | 10 | 72 | 10 | 261 | 28.8 | cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes | cytoskeleton;nucleus;other cell component | signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function | 18538 | ENSMUSG00000027342 | Pcna | mmu:18538; P17918 | Mismatch repair; Oxidative damage response; Primary focal segmental glomerulosclerosis (FSGS); G1 to S cell cycle control | SUMOylation of DNA replication proteins; Recognition of DNA damage by PCNA-containing replication complex; Dual Incision in GG-NER; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; E3 ubiquitin ligases ubiquitinate target proteins; Translesion Synthesis by POLH; Removal of the Flap Intermediate from the C-strand; HDR through Homologous Recombination (HRR); Polymerase switching on the C-strand of the telomere; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); PCNA-Dependent Long Patch Base Excision Repair; Termination of translesion DNA synthesis; Gap-filling DNA repair synthesis and ligation in GG-NER; Polymerase switching; Removal of the Flap Intermediate; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI | 0.47541602898497 | 0.381096727990464 | 0.826374720306471 | 0.887279041944908 | 0.976873891151678 | 0.875834610955903 | 0.801115710342179 | 0.960067393782086 | 30394.0784140218 | 28223.1432049833 | 51039.1401172933 | 1048820.20711846 | 801337.653436883 | 247250.67661959 | 374114.747314153 | 480325.704001997 | 735211.286888396 | 991704.93840689 | 1000418.19420179 | 610371.374274365 | 344506.254592942 | 153604.395914592 | 435556.607204553 |
| P11499 | Heat shock protein HSP 90-beta [OS=Mus musculus] | 164.719 | 50 | 29 | 532 | 19 | 724 | 83.2 | cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component | enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function | 15516 | ENSMUSG00000023944 | Hsp90ab1 | mmu:15516; O89078; P11499; Q3UIQ7 | Focal adhesion: PI3K-Akt-mTOR signaling pathway | Neutrophil degranulation; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of actin dynamics for phagocytic cup formation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Attenuation phase; Estrogen-dependent gene expression; Sema3A PAK dependent Axon repulsion; Aryl hydrocarbon receptor signalling; DDX58/IFIH1-mediated induction of interferon-alpha/beta; HSF1 activation; RHOBTB2 GTPase cycle; The NLRP3 inflammasome | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.952333191127893 | 0.385192173946943 | 0.975071223710592 | 0.476079393565723 | 221410.585638305 | 129165.68527882 | 147525.692220339 | 3.34627647115336E7 | 3.61961534999558E7 | 2.61391308788083E7 | 9541203.16877468 | 9273367.56835581 | 1.36082703259873E7 | 4.57710434253974E7 | 4.37708354854306E7 | 3.73056416942256E7 | 1.17622035416132E7 | 7437513.65495311 | 1.56244060515822E7 |
| Q64727 | Vinculin [OS=Mus musculus] | 182.753 | 50 | 45 | 419 | 45 | 1066 | 116.6 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | plasma membrane;other membranes;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 22330 | ENSMUSG00000021823 | Vcl | mmu:22330; Q64727; Q8BP32; Q8BS46; Q922C5; Q922D9 | Primary focal segmental glomerulosclerosis (FSGS); IL-3 signaling pathway; Regulation of actin cytoskeleton; Integrin-mediated cell adhesion; Focal adhesion | Neutrophil degranulation; High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells; Platelet degranulation ; MAP2K and MAPK activation; Smooth Muscle Contraction; Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells; Regulation of CDH1 Function | 0.208404050858596 | 0.190838415616571 | 0.238791978742132 | 0.504745711776551 | 0.964629994744883 | 0.878264980963866 | 0.977491813528386 | 0.958518237573655 | 199164.849916128 | 87100.0128702587 | 92185.322880836 | 5675245.0989599 | 5838625.66584249 | 3008640.49360623 | 1870082.63283096 | 1414114.90526218 | 2577750.73562883 | 7844023.43396073 | 7226639.25078312 | 5204108.91618431 | 2343388.9049214 | 1587883.53032107 | 3146179.30802337 |
| Cont_P12763 | Alpha-2-HS-glycoprotein OS=Bos taurus OX=9913 GN=AHSG PE=1 SV=2 | 132.772 | 50 | 16 | 1191 | 16 | 359 | 38.4 | stress response;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component | enzyme regulator activity | 280988 | AHSG | A6QLF7; bta:280988; P12763 | Neutrophil degranulation; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 0.573667790345329 | 0.793013134473823 | 0.624272910267193 | 0.36488675645736 | 0.946568086066385 | 0.268930374946741 | 0.335956814949331 | 0.913214993335179 | 6.75081036645858E8 | 9.56771805796805E8 | 4.32862555462728E8 | 6.04790296716478E8 | 6.42824998486085E8 | 6.76887564991134E8 | 8.54466282868744E8 | 8.4303805016043E8 | 9.16216503216691E8 | 7.41908408260606E8 | 7.48114705273509E8 | 6.29285280642112E8 | 3.25834950231514E8 | 3.42283489676807E8 | 6.64083343401506E8 | ||
| Q9JJH1 | Ribonuclease 4 [OS=Mus musculus] | 40.55 | 50 | 5 | 68 | 5 | 148 | 17 | stress response | nucleic acid binding activity;other molecular function | Rnase4 | Q9JJH1 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.405171272046276 | 0.97873503980026 | 0.319352164925032 | 0.990873516209569 | 900667.538795762 | 626495.60020001 | 674430.457749758 | 662460.788807247 | 418296.869814139 | 357229.483785163 | 806175.295812985 | 559706.117690068 | 632695.69219141 | 162317.682356543 | 82344.2531139482 | 351979.742895469 | ||||||||
| Q62356 | Follistatin-related protein 1 [OS=Mus musculus] | 101.698 | 50 | 13 | 395 | 13 | 306 | 34.5 | other biological processes | other molecular function | 14314 | ENSMUSG00000022816 | Fstl1 | mmu:14314; Q62356; Q6GTX2; Q99JI9 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Signaling by BMP | 0.234155704553915 | 0.76011950876399 | 0.758743075163871 | 0.858718647932906 | 0.0316468709291523 | 0.64816721735177 | 0.0857649907305965 | 0.896996950298791 | 41191.3351778335 | 108686.460674569 | 6.60207465015646E7 | 8.29713475942257E7 | 1.0059723968955E8 | 3.32110573276478E7 | 2.78551354522178E7 | 3.32507182180078E7 | 2.69623700732219E7 | 2.59261419226059E7 | 2.01925652875171E7 | 8207327.88504086 | 3463595.51170135 | 1.55118780287692E7 | |||
| Q9DBJ1 | Phosphoglycerate mutase 1 [OS=Mus musculus] | 66.001 | 50 | 9 | 141 | 9 | 254 | 28.8 | other metabolic processes | cytosol | other molecular function | 18648 | ENSMUSG00000011752 | Pgam1 | mmu:18648; Q9D6W0; Q9DBJ1; Q9ERT3 | Glycolysis and gluconeogenesis | Neutrophil degranulation; Gluconeogenesis; Glycolysis | 0.924864918132342 | 0.864213133022801 | 0.975483104913309 | 0.960450265090932 | 0.974827674952665 | 0.916542675526027 | 0.878843662685239 | 0.845300575646214 | 142576.777637381 | 198989.798164436 | 179788.671508667 | 2533554.33709426 | 2890204.49008964 | 2276325.08551472 | 1021326.4396357 | 939216.255648303 | 1157962.44230927 | 2843510.34247197 | 4617230.42091798 | 3461989.40298788 | 1602217.88853036 | 1109233.08749405 | 2483926.33322519 |
A
B
C
D
E
F
G
H
I
J
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
| Peptides | 2 | ||||||||
| U peptides | 1 | ||||||||
| Coverage >= | 0.04 | ||||||||
A
B
C
D
E
F
G
H
I
J
K
L
M
N
O
P
Q
R
S
T
U
V
W
X
Y
Z
AA
AB
AC
AD
AE
AF
AG
AH
AI
AJ
AK
AL
AM
AN
AO
AP
AQ
AR
AS
AT
AU
AV
AW
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
| Accession | Description | Sum PEP Score | Coverage [%] | # Peptides | # PSMs | # Unique Peptides | # AAs | MW [kDa] | Biological Process | Cellular Component | Molecular Function | Entrez Gene ID | Ensembl Gene ID | Gene Symbol | Gene ID | WikiPathways | Reactome Pathways | Abundance Ratio: (LQ_16h) / FM | Abundance Ratio: (LQ_6h) / FM | Abundance Ratio: (SQ_16h) / FM | Abundance Ratio: (SQ_6h) / FM | Abundance Ratio: (SQ_16h) / (LQ_16h) | Abundance Ratio: (LQ_16h) / (LQ_6h) | Abundance Ratio: (SQ_6h) / (LQ_6h) | Abundance Ratio: (SQ_16h) / (SQ_6h) | Abundance Ratio Adj. P-Value: (LQ_16h) / FM | Abundance Ratio Adj. P-Value: (LQ_6h) / FM | Abundance Ratio Adj. P-Value: (SQ_16h) / FM | Abundance Ratio Adj. P-Value: (SQ_6h) / FM | Abundance Ratio Adj. P-Value: (SQ_16h) / (LQ_16h) | Abundance Ratio Adj. P-Value: (LQ_16h) / (LQ_6h) | Abundance Ratio Adj. P-Value: (SQ_6h) / (LQ_6h) | Abundance Ratio Adj. P-Value: (SQ_16h) / (SQ_6h) | Abundances (Normalized): F1: Sample, FM | Abundances (Normalized): F2: Sample, FM | Abundances (Normalized): F3: Sample, FM | Abundances (Normalized): F8: Sample, LQ_16h | Abundances (Normalized): F9: Sample, LQ_16h | Abundances (Normalized): F10: Sample, LQ_16h | Abundances (Normalized): F4: Sample, LQ_6h | Abundances (Normalized): F5: Sample, LQ_6h | Abundances (Normalized): F6: Sample, LQ_6h | Abundances (Normalized): F17: Sample, SQ_16h | Abundances (Normalized): F18: Sample, SQ_16h | Abundances (Normalized): F20: Sample, SQ_16h | Abundances (Normalized): F14: Sample, SQ_6h | Abundances (Normalized): F15: Sample, SQ_6h | Abundances (Normalized): F16: Sample, SQ_6h |
| P11276 | Fibronectin [OS=Mus musculus] | 867.353 | 58 | 95 | 2246 | 59 | 2477 | 272.4 | cell adhesion;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi | signal transduction activity or receptor binding;enzyme regulator activity;other molecular function | 14268 | ENSMUSG00000026193 | Fn1 | G5E8B8; mmu:14268; P11276; Q61567; Q61568; Q61569; Q64233; Q80UI4 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Inflammatory response pathway; Regulation of actin cytoskeleton; Comprehensive IL-17A signaling; Focal adhesion | ECM proteoglycans; Platelet degranulation ; Cell surface interactions at the vascular wall; Syndecan interactions; MAP2K and MAPK activation; Integrin cell surface interactions; Molecules associated with elastic fibres; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Fibronectin matrix formation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; Degradation of the extracellular matrix; Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells; MET activates PTK2 signaling; GPER1 signaling | 16.191 | 18.678 | 20 | 12.982 | 1.439 | 0.984 | 0.516 | 2.74 | 0.0844744457809114 | 0.00584906503121538 | 1.50457038391225E-17 | 0.156115961659409 | 0.974036928885484 | 0.564710097967506 | 0.435823028559966 | 0.896613838854506 | 3.10111960161575E7 | 2.79853612635427E7 | 2.39278028537136E7 | 2.27076161669542E8 | 2.29530848002383E8 | 1.81481696567249E8 | 2.13523563015262E8 | 1.92386583493888E8 | 2.00792310651879E8 | 3.0604731494329E8 | 2.72875123758133E8 | 2.45952285820886E8 | 1.1928889459527E8 | 1.00071254189999E8 | 1.59531432686856E8 |
| P11087 | Collagen alpha-1(I) chain [OS=Mus musculus] | 797.017 | 79 | 75 | 1933 | 35 | 1453 | 137.9 | cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12842 | ENSMUSG00000001506 | Col1a1 | mmu:12842; P11087; Q53WT0; Q60635; Q61367; Q61427; Q63919; Q6PCL3; Q810J9 | Osteoblast signaling; Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Comprehensive IL-17A signaling; Focal adhesion | Cell surface interactions at the vascular wall; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ECM proteoglycans; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; GPVI-mediated activation cascade; GP1b-IX-V activation signalling; Platelet Adhesion to exposed collagen; Platelet Aggregation (Plug Formation); MET activates PTK2 signaling | 20 | 20 | 20 | 20 | 0.142 | 3.208 | 0.295 | 1.664 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 1.58880673198775E-4 | 0.381922652011049 | 0.0629214061377862 | 0.655833157547641 | 703080.609341466 | 1047026.5902454 | 567207.050774397 | 6.12803341835757E8 | 6.28616080368892E8 | 5.37143706349406E8 | 2.20652487774689E8 | 1.86114398805651E8 | 2.17194307013081E8 | 9.46570689754052E7 | 9.72166914362706E7 | 6.09758172025116E7 | 6.01286898886734E7 | 4.84358218594371E7 | 7.06441702532683E7 |
| Q01149 | Collagen alpha-2(I) chain [OS=Mus musculus] | 773.662 | 80 | 66 | 1731 | 51 | 1372 | 129.5 | cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12843 | ENSMUSG00000029661 | Col1a2 | mmu:12843; Q01149; Q8CGA5 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Focal adhesion | Crosslinking of collagen fibrils; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; ECM proteoglycans; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; GPVI-mediated activation cascade; GP1b-IX-V activation signalling; Platelet Adhesion to exposed collagen; Platelet Aggregation (Plug Formation); MET activates PTK2 signaling | 20 | 20 | 20 | 20 | 0.279 | 2.097 | 0.261 | 2.151 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.0150838661305169 | 0.862063111456553 | 0.0347692006632991 | 0.926292871155025 | 217896.573253055 | 102775.453905646 | 225868.955510701 | 3.82374533805921E8 | 3.80614155239716E8 | 2.79801552870279E8 | 1.73556920519588E8 | 1.55763113653521E8 | 1.89931753802048E8 | 1.03217412397752E8 | 1.04517075360638E8 | 6.33578194684048E7 | 4.96147162399626E7 | 2.65479311979207E7 | 5.19818116295111E7 |
| P08121 | Collagen alpha-1(III) chain [OS=Mus musculus] | 695.631 | 63 | 61 | 1789 | 51 | 1464 | 138.9 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | extracellular matrix;other cell component | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 12825 | ENSMUSG00000026043 | Col3a1 | mmu:12825; P08121; Q61429; Q9CRN7 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Focal adhesion | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ECM proteoglycans; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; MET activates PTK2 signaling | 20 | 20 | 20 | 20 | 0.247 | 5.055 | 0.497 | 2.464 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.00738207855214502 | 0.0413994480640273 | 0.394949139624895 | 0.976852696203657 | 619884.023482232 | 468692.52789102 | 275667.802679115 | 2.79020579584843E8 | 2.94236692581693E8 | 2.78582579285209E8 | 6.51340156000414E7 | 5.70632610319163E7 | 6.62894421161806E7 | 7.54516142044654E7 | 7.68700494785543E7 | 4.61499837269909E7 | 3.06665885804687E7 | 2.39448217703501E7 | 3.64849658219652E7 |
| Q9QXS1 | Plectin [OS=Mus musculus] | 659.702 | 46 | 182 | 1705 | 180 | 4691 | 533.9 | cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component | cytoskeletal activity;other molecular function | 18810 | ENSMUSG00000022565 | Plec | E9QN87; mmu:18810; Q6S384; Q6S389; Q6S394; Q9CS65; Q9QUT2; Q9QXQ8; Q9QXQ9; Q9QXR0; Q9QXR1; Q9QXR2; Q9QXR3; Q9QXR4; Q9QXR5; Q9QXR6; Q9QXR7; Q9QXR8; Q9QXR9; Q9QXS0; Q9QXS1; Q9QXS2; Q9QXS3 | Alpha 6 beta 4 integrin signaling pathway; EGFR1 signaling pathway | Type I hemidesmosome assembly; Caspase-mediated cleavage of cytoskeletal proteins | 5.459 | 2.593 | 9.846 | 4.989 | 2.383 | 2.864 | 1.839 | 3.715 | 0.481729871164266 | 0.714932595871944 | 0.336550483871782 | 0.572524806937582 | 0.850917681937748 | 0.532399788858771 | 0.702330308974487 | 0.520376293994664 | 307407.817065559 | 282192.990008148 | 340166.735457239 | 1.95783440606639E7 | 1.89230076526173E7 | 1.15266683074569E7 | 3962115.44279651 | 3474477.32513512 | 6361226.57462356 | 5.1842207663806E7 | 4.48709077668655E7 | 3.18339270889303E7 | 1.10137014373925E7 | 7604177.6415354 | 1.18325057871337E7 |
| P08122 | Collagen alpha-2(IV) chain [OS=Mus musculus] | 526.992 | 64 | 69 | 1077 | 69 | 1707 | 167.2 | RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix | extracellular structural activity | 12827 | ENSMUSG00000031503 | Col4a2 | mmu:12827; P08122; Q3B7C2; Q3TPV9; Q61375; Q66JS5; Q6RCT6; Q6RCT7; Q6U9X1; Q8BPI9; Q8BPK3; Q91VI3 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Focal adhesion | Laminin interactions; Signaling by PDGF; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions | 7.029 | 2.876 | 10.91 | 3.309 | 1.603 | 3.934 | 1.208 | 3.852 | 0.352816378116182 | 0.64759425713406 | 0.293387877727491 | 0.79866917976589 | 0.979628232635575 | 0.169673447599406 | 0.959159975702413 | 0.483015668880262 | 1499335.01530309 | 1691518.00623855 | 989751.415380184 | 5.53234274481973E7 | 5.88619201086468E7 | 3.63990683013196E7 | 1.35123643610626E7 | 1.30555597235297E7 | 1.53773176128868E7 | 6.80333035906639E7 | 6.55922447276284E7 | 4.55601360762201E7 | 1.71661195678148E7 | 9511844.25395737 | 2.43703078917008E7 |
| Q3U962 | Collagen alpha-2(V) chain [OS=Mus musculus] | 518.514 | 64 | 57 | 817 | 55 | 1497 | 144.9 | cell organization and biogenesis;developmental processes;other biological processes | extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12832 | ENSMUSG00000026042 | Col5a2 | mmu:12832; Q3TVR2; Q3U962; Q3UHK7; Q3UTT4; Q3V1J6; Q61431; Q7TMS0; Q80VS8 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions | 1.598 | 1.546 | 1.519 | 1.021 | 0.385 | 3.505 | 0.525 | 2.477 | 0.861384746267066 | 0.961254912149485 | 0.730324052254867 | 0.632833892117728 | 0.0769666553885184 | 0.273444295895674 | 0.453486790198347 | 0.973358018692255 | 1.96082795853326E7 | 1.89754303457921E7 | 3.46758133166589E7 | 4.80275081428664E7 | 4.79991185130461E7 | 4.1747532446715E7 | 1.59204573672189E7 | 1.42782577106181E7 | 1.7061559679881E7 | 2.09575588581227E7 | 1.96948053072084E7 | 2.25862916575107E7 | 1.85137908486988E7 | 4881772.8383399 | 8018525.34642114 |
| Q05793 | Basement membrane-specific heparan sulfate proteoglycan core protein [OS=Mus musculus] | 507.28 | 33 | 84 | 998 | 84 | 3707 | 398 | cell organization and biogenesis;transport;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;ER/Golgi | other molecular function | 15530 | Hspg2 | mmu:15530; Q05793 | 7.351 | 4.161 | 3.918 | 5.169 | 0.496 | 1.868 | 0.437 | 2.1 | 0.332090710292395 | 0.382764581022518 | 0.771134174410141 | 0.553652046981626 | 0.208890689478245 | 0.938381933295379 | 0.285967432697218 | 0.908661395894721 | 136795.508290338 | 206406.403199821 | 169825.859706297 | 3.70110206606215E7 | 4.34630743166815E7 | 4.28074794537461E7 | 2.41165287907714E7 | 1.91842080304052E7 | 2.07659482289725E7 | 2.10452863152835E7 | 2.06741361608803E7 | 1.52751209810576E7 | 8226367.86740312 | 5927226.99682882 | 1.0580617159021E7 | |||
| Q61554 | Fibrillin-1 [OS=Mus musculus] | 499.202 | 38 | 86 | 1117 | 86 | 2873 | 312.1 | cell adhesion;other metabolic processes;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 14118 | ENSMUSG00000027204 | Fbn1 | A2AQ53; mmu:14118; Q60826; Q61554 | Comprehensive IL-17A signaling | Integrin cell surface interactions; Degradation of the extracellular matrix; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; TGF-beta receptor signaling activates SMADs; Molecules associated with elastic fibres | 18.996 | 8.247 | 8.911 | 3.018 | 0.396 | 2.1 | 0.276 | 3.153 | 0.0596853092747711 | 0.0840496117897429 | 0.378389090130589 | 0.84258396038376 | 0.087482121441914 | 0.862063111456553 | 0.0455630470425967 | 0.77820123247099 | 95282.9912894267 | 109686.773968107 | 40225.7464170883 | 5.82457893686458E7 | 6.62931141873392E7 | 3.19536333419291E7 | 2.33066180631659E7 | 1.9035713753758E7 | 2.29784126659734E7 | 2.39841959808407E7 | 2.29999435869113E7 | 1.54925740961197E7 | 5514536.56061601 | 2575605.08863811 | 7345083.32475891 |
| Q8BTM8 | Filamin-A [OS=Mus musculus] | 493.069 | 49 | 91 | 915 | 83 | 2647 | 281 | cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;other molecular function | 192176 | ENSMUSG00000031328 | Flna | B7FAV0; O54934; Q7TQI1; Q8BLK1; Q8BTM8; Q8BTN7; Q8VHX5; Q8VHX8; Q99KQ2 | Mapk signaling pathway; Focal adhesion | Platelet degranulation ; Cell-extracellular matrix interactions; RHO GTPases activate PAKs; GP1b-IX-V activation signalling | 16.184 | 3.535 | 15.745 | 4.108 | 1.303 | 2.08 | 0.901 | 2.899 | 0.0844935092512095 | 0.493514006575528 | 0.170420349138264 | 0.67528135146603 | 0.946239447314336 | 0.864215513767001 | 0.904360680536565 | 0.8468455705593 | 223080.302738683 | 192779.021360071 | 239583.24348992 | 1.21506602248127E7 | 1.23160583881327E7 | 9719435.76620134 | 4325195.00464495 | 4176073.86658823 | 6355593.34436329 | 1.73054238441738E7 | 1.42527501066511E7 | 1.24998953996761E7 | 4531038.34565544 | 2879720.55833739 | 5479053.39146785 |
| P02463 | Collagen alpha-1(IV) chain [OS=Mus musculus] | 487.707 | 70 | 68 | 828 | 68 | 1669 | 160.6 | cell organization and biogenesis;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix | extracellular structural activity;other molecular function | 12826 | ENSMUSG00000031502 | Col4a1 | mmu:12826; P02463; Q3UHJ4; Q3UJE7; Q3UQV2; Q53X35; Q6GQS7; Q6PHB5; Q99LQ8 | Spinal cord injury; Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Laminin interactions; Signaling by PDGF; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions | 4.371 | 1.004 | 11.171 | 2.458 | 3.498 | 3.947 | 1.69 | 4.683 | 0.604225174343649 | 0.68008321917751 | 0.284160251285083 | 0.936818656936794 | 0.483508479481234 | 0.167300285011781 | 0.777395712279767 | 0.224623005929948 | 359769.877634713 | 285958.835932462 | 141085.539092917 | 2.00868956379824E7 | 2.17854047157598E7 | 2.25190928918174E7 | 4657081.16483192 | 4119739.1632835 | 5084724.84322114 | 3.91843343162395E7 | 3.69562703398771E7 | 2.33283395840594E7 | 7286914.931104 | 6193195.94075903 | 1.32557370999003E7 |
| Q60847 | Collagen alpha-1(XII) chain [OS=Mus musculus] | 480.266 | 40 | 95 | 991 | 95 | 3120 | 340 | cell adhesion;developmental processes | other cell component | 12816 | ENSMUSG00000032332 | Col12a1 | mmu:12816; P70322; Q60847 | Assembly of collagen fibrils and other multimeric structures; Collagen chain trimerization; Collagen degradation | 15.041 | 20 | 9.674 | 12.612 | 0.427 | 0.631 | 0.21 | 1.243 | 0.0975092237649803 | 1.8644578313253E-17 | 0.344512840834051 | 0.162753188077458 | 0.119424004207039 | 0.101350980560035 | 0.0103905836841461 | 0.266844028199729 | 98450.5264125119 | 58090.3600627237 | 83999.6481680613 | 3.34408474370425E7 | 3.89438836318894E7 | 1.74727378978336E7 | 5.74848700994307E7 | 4.49447732262548E7 | 5.27793485517261E7 | 1.71723257401258E7 | 1.50709974901674E7 | 1.16453026750935E7 | 1.0899125462023E7 | 6848854.24799245 | 1.38653609093446E7 | ||
| Q8VDD5 | Myosin-9 [OS=Mus musculus] | 418.364 | 45 | 73 | 827 | 60 | 1960 | 226.2 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;stress response;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;other molecular function | 17886 | ENSMUSG00000022443 | Myh9 | mmu:17886; Q3UHT9; Q3UHU4; Q6KAN6; Q811I2; Q8VDD5 | Primary focal segmental glomerulosclerosis (FSGS) | RHO GTPases activate PAKs; Regulation of actin dynamics for phagocytic cup formation | 11.694 | 10.853 | 19.492 | 13.21 | 2.21 | 1.427 | 1.339 | 2.347 | 0.156498497144098 | 0.0382609387499984 | 0.118876667035285 | 0.15125389278925 | 0.87421335771164 | 0.916542675526027 | 0.91728043005175 | 0.990873516209569 | 107483.529676039 | 153800.887463573 | 39674.4269878413 | 8783012.74886087 | 9974545.70796386 | 5444477.78467149 | 4748384.28257292 | 4410554.6604061 | 6370665.87897293 | 2.10207699044932E7 | 2.09758895852136E7 | 1.72823293907493E7 | 8538625.93793802 | 5517905.75659883 | 9476865.41359831 |
| Cont_P02453 | Collagen alpha-1(I) chain OS=Bos taurus OX=9913 GN=COL1A1 PE=1 SV=3 | 414.689 | 43 | 43 | 1208 | 4 | 1463 | 138.9 | cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | 282187 | ENSBTAG00000013103 | COL1A1 | bta:282187; P02453; Q3MHM2 | Inflammatory response pathway; Osteoblast signaling; Focal adhesion | Fibronectin matrix formation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Collagen degradation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; Collagen chain trimerization; GPVI-mediated activation cascade; Platelet Aggregation (Plug Formation); Platelet Adhesion to exposed collagen; GP1b-IX-V activation signalling | 1.443 | 0.869 | 1.124 | 1.501 | 0.374 | 1.284 | 0.335 | 0.775 | 0.800889767710788 | 0.579410556046386 | 0.58548007712969 | 0.839216523231753 | 0.067749585016969 | 0.848119069115724 | 0.108042253370914 | 0.0107964100780951 | 246464.336302772 | 276104.509600215 | 163058.776827813 | 4343807.62117337 | 4270443.00602544 | 3115927.46864821 | 3219828.72869598 | 3183952.03023541 | 3383679.40073467 | 941743.224351002 | 1075861.66368366 | 756862.710693879 | 1364509.18546901 | 876331.391932507 | 1065336.29340721 |
| Cont_P02769 | Albumin OS=Bos taurus OX=9913 GN=ALB PE=1 SV=4 | 390.555 | 81 | 57 | 7095 | 54 | 607 | 69.2 | stress response;other biological processes | non-structural extracellular;other cell component | nucleic acid binding activity;other molecular function | 280717 | ALB | A5PJX3; bta:280717; O02787; P02769; P04277; Q3SZR2 | 0.86 | 0.957 | 1.154 | 0.79 | 1.314 | 0.876 | 0.791 | 1.45 | 0.520832629933248 | 0.650544967914241 | 0.598172767155558 | 0.497906326712893 | 0.946568086066385 | 0.413798631523592 | 0.846117085258013 | 0.468531677746422 | 3.41035277502904E9 | 3.06531085647989E9 | 1.66716629813739E9 | 2.0547979326133E9 | 2.37062763488737E9 | 2.78500610382043E9 | 3.09362764542436E9 | 2.55631644026836E9 | 3.07992745656962E9 | 2.97814649224141E9 | 2.86277256421772E9 | 2.21144220575444E9 | 1.66052966718895E9 | 2.22855277531216E9 | 3.25384623573346E9 | |||
| P01027 | Complement C3 [OS=Mus musculus] | 388.541 | 53 | 70 | 1148 | 62 | 1663 | 186.4 | cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular;other cell component | signal transduction activity or receptor binding;enzyme regulator activity | 12266 | ENSMUSG00000024164 | C3 | mmu:12266; P01027; Q61370; Q80XP1 | Complement activation, classical pathway; Tyrobp causal network in microglia; Comprehensive IL-17A signaling | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade; Neutrophil degranulation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; G alpha (i) signalling events; Peptide ligand-binding receptors; Alternative complement activation; Activation of C3 and C5 | 3.547 | 2.537 | 6.803 | 3.529 | 1.878 | 2.911 | 2.425 | 2.35 | 0.712660037675161 | 0.729783028721347 | 0.506101547380209 | 0.762068821001752 | 0.939492000987438 | 0.512232143465318 | 0.413470300505934 | 0.991722673088443 | 4040096.73815256 | 3926631.83282415 | 1843021.41157313 | 4.04154698805798E7 | 4.4896658832648E7 | 4.8335201547635E7 | 1.80671896153384E7 | 1.47828809765086E7 | 1.7121367805152E7 | 9.88883606977539E7 | 8.1974398309486E7 | 5.99376709525504E7 | 3.21393016835685E7 | 2.84159228355073E7 | 4.96444404075474E7 |
| Cont_Q7SIH1 | Alpha-2-macroglobulin OS=Bos taurus OX=9913 GN=A2M PE=1 SV=2 | 370.864 | 53 | 56 | 1089 | 56 | 1510 | 167.5 | non-structural extracellular | enzyme regulator activity;other molecular function | 513856 | ENSBTAG00000018137 | A2M | A8E647; bta:513856; Q7SIH1 | IL-6 signaling pathway | 1.169 | 1.273 | 1.523 | 0.809 | 1.276 | 0.967 | 0.649 | 1.845 | 0.688450665125024 | 0.839052280267302 | 0.731111241255251 | 0.509007335932165 | 0.944154202827561 | 0.540124873725708 | 0.671798309985569 | 0.809503222445875 | 5.71770657169572E7 | 6.35766951637367E7 | 4.19549690627817E7 | 6.46032237401637E7 | 7.37926671048822E7 | 7.2164410166051E7 | 8.06000315293491E7 | 7.23429494984619E7 | 7.40068576999505E7 | 8.7810317845685E7 | 9.50258669209954E7 | 6.46884849507494E7 | 4.10565401116459E7 | 3.96461495018234E7 | 7.63451634810678E7 | ||
| Cont_Q29443 | Serotransferrin OS=Bos taurus OX=9913 GN=TF PE=2 SV=1 | 343.183 | 74 | 48 | 1709 | 46 | 704 | 77.7 | stress response;transport;other biological processes | non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle | other molecular function | 280705 | TF | bta:280705; Q0IIK2; Q29443 | 1.017 | 1.563 | 1.16 | 0.912 | 1.118 | 0.635 | 0.55 | 1.293 | 0.615274986253429 | 0.964709887217926 | 0.600414647182016 | 0.571407162236119 | 0.902231721267411 | 0.105569810421019 | 0.506704636011438 | 0.313748671859839 | 1.71679936327392E8 | 1.91001417946965E8 | 8.41149187199369E7 | 1.24867801818358E8 | 1.55146358811954E8 | 1.88178132242021E8 | 2.69795837029218E8 | 2.21755859229163E8 | 2.04768415701638E8 | 1.81082969779594E8 | 1.61167381210782E8 | 1.45463022007429E8 | 9.18433757916485E7 | 1.38609619584445E8 | 1.76572700073531E8 | |||
| Cont_P07589 | Fibronectin OS=Bos taurus OX=9913 GN=FN1 PE=1 SV=4 | 337.517 | 26 | 47 | 923 | 11 | 2478 | 272 | cell adhesion;cell organization and biogenesis;stress response;developmental processes;other biological processes | non-structural extracellular | signal transduction activity or receptor binding;other molecular function | FN1 | P07589 | 3.52 | 3.363 | 2.311 | 1.395 | 0.714 | 1.039 | 0.476 | 1.31 | 0.714071857030863 | 0.525827426782658 | 0.94971810013306 | 0.802863674292211 | 0.553450172742796 | 0.634088329627404 | 0.35834247597224 | 0.281927255363179 | 142865.797461343 | 209169.389049115 | 146732.075795441 | 1055759.20189889 | 1052518.92691246 | 748231.640959004 | 927817.269350189 | 797644.80797335 | 782189.414628216 | 683356.768802769 | 735882.167003896 | 388557.285212602 | 606468.327162644 | 334439.098432858 | 506951.879121439 | ||||
| Q80X90 | Filamin-B [OS=Mus musculus] | 335.882 | 38 | 75 | 608 | 66 | 2602 | 277.7 | cell organization and biogenesis;stress response;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 286940 | ENSMUSG00000025278 | Flnb | E9QNV9; mmu:286940; Q80X90; Q8VHX4; Q8VHX7; Q99KY3 | ISG15 antiviral mechanism | 7.928 | 5.332 | 12.124 | 4.491 | 1.209 | 1.979 | 0.842 | 2.845 | 0.296944306247309 | 0.238365792894698 | 0.254729742039053 | 0.629546282386664 | 0.936411452199724 | 0.897564267605108 | 0.872448101434609 | 0.866446545996913 | 201569.562939035 | 74814.3999578854 | 187488.727848728 | 5908241.65562211 | 7025090.54357015 | 5213153.27323614 | 2307098.04671866 | 1545558.91097354 | 3200680.70273347 | 8948631.41531232 | 7437294.37435051 | 6391778.7211006 | 1867290.64861647 | 1318356.62479586 | 2409815.97001446 | |
| Cont_P35527 | Keratin, type I cytoskeletal 9 OS=Homo sapiens OX=9606 GN=KRT9 PE=1 SV=3 | 310.424 | 69 | 35 | 915 | 34 | 623 | 62 | cell organization and biogenesis;other biological processes | cytosol;cytoskeleton | cytoskeletal activity | 3857 | ENSG00000171403 | KRT9 | hsa:3857; O00109; P35527; Q0IJ47; Q14665 | Formation of the cornified envelope | 1.535 | 1.081 | 1.647 | 2.287 | 1.044 | 1.471 | 2.208 | 0.777 | 0.836660982916281 | 0.73072258897653 | 0.769556732848094 | 0.964570089320365 | 0.873609880131656 | 0.936669139837906 | 0.516448827835279 | 0.0110179641295352 | 3.00988862408693E7 | 2.22166955848562E7 | 3.53566605858277E7 | 3.83413938796298E7 | 4.01115354911529E7 | 4.55013850626263E7 | 3.25056930591839E7 | 3.99576081794461E7 | 2.50556157717982E7 | 4.79768166310243E7 | 2.93517742058567E7 | 7.69722436015544E7 | 1.31711700890849E8 | 9.27838604678364E7 | 5.6604390657593E7 | |
| Cont_P04264 | Keratin, type II cytoskeletal 1 OS=Homo sapiens OX=9606 GN=KRT1 PE=1 SV=6 | 306.58 | 65 | 45 | 1774 | 36 | 644 | 66 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;other molecular function | 3848 | ENSG00000167768 | KRT1 | B2RA01; hsa:3848; P04264; P85925; P86104; Q14720; Q6GSJ0; Q9H298 | Corticotropin-releasing hormone signaling | Formation of the cornified envelope; Neutrophil degranulation; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 1.103 | 0.963 | 1.229 | 2.667 | 1.042 | 1.184 | 2.925 | 0.472 | 0.65780924735352 | 0.653826967689551 | 0.631165145316661 | 0.89629386854896 | 0.873609880131656 | 0.770634810212039 | 0.254077056479593 | 5.78940441291519E-5 | 1.31038801811221E8 | 1.49848314576813E8 | 1.81048519054156E8 | 1.64179912336924E8 | 1.70861004616453E8 | 1.60803236136221E8 | 1.32005397364365E8 | 1.61355773356369E8 | 1.09071204525108E8 | 1.84835731298625E8 | 1.38277867637903E8 | 2.0582953187505E8 | 6.47574942932283E8 | 3.95085049343759E8 | 3.00261678765842E8 |
| P06909 | Complement factor H [OS=Mus musculus] | 292.01 | 49 | 41 | 540 | 41 | 1234 | 139 | cell adhesion;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes | non-structural extracellular;plasma membrane;other membranes;mitochondrion;other cell component | other molecular function | 12628 | ENSMUSG00000026365 | Cfh | mmu:12628; P06909; Q6NZK3 | Regulation of Complement cascade | 10 | 11.089 | 20 | 8.058 | 2.955 | 0.961 | 0.704 | 3.964 | 0.205200089226065 | 0.0359547312524068 | 1.50457038391225E-17 | 0.329485122608543 | 0.678323397545056 | 0.532399788858771 | 0.750662231008662 | 0.443116920082088 | 45833.2314948132 | 5719.34924483144 | 127074.400703141 | 9199603.23733176 | 9631512.57691777 | 1.22513356989878E7 | 1.13946236540082E7 | 8948376.12127358 | 1.13575209573925E7 | 3.40837407850627E7 | 2.84575354110008E7 | 2.55312981422866E7 | 7658800.41775084 | 6857257.31092971 | 1.08034871236965E7 | |
| P16546 | Spectrin alpha chain, non-erythrocytic 1 [OS=Mus musculus] | 291.854 | 35 | 74 | 473 | 74 | 2472 | 284.4 | cell organization and biogenesis | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 20740 | ENSMUSG00000057738 | Sptan1 | A3KGU6; A3KGU8; P16546; Q8K380; Q9CT05 | FAS pathway and stress induction of HSP regulation | Neutrophil degranulation; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Interaction between L1 and Ankyrins; COPI-mediated anterograde transport; RHOU GTPase cycle; RHOV GTPase cycle; Caspase-mediated cleavage of cytoskeletal proteins | 2.273 | 1.172 | 5.466 | 1.689 | 1.972 | 2.321 | 1.488 | 2.88 | 0.958962194559628 | 0.786160319109602 | 0.611910908670005 | 0.890289034593217 | 0.929383260195332 | 0.771887919257916 | 0.870511801558508 | 0.852906094467594 | 889916.065158961 | 705414.766907556 | 458549.490375553 | 4175162.43226982 | 4600176.71769719 | 3155429.78771999 | 1301153.76848032 | 907755.21332001 | 2072924.21437361 | 9282178.93349268 | 8610756.12905297 | 6522130.81446154 | 2340149.67970916 | 1477626.07784989 | 2972528.81421804 |
| Cont_P13645 | Keratin, type I cytoskeletal 10 OS=Homo sapiens OX=9606 GN=KRT10 PE=1 SV=6 | 286.713 | 62 | 30 | 1322 | 20 | 584 | 58.8 | cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes | plasma membrane;cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;other molecular function | 3858 | ENSG00000186395 | KRT10 | hsa:3858; P13645; Q14664; Q8N175 | Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.992 | 0.771 | 1.072 | 2.427 | 0.958 | 1.365 | 2.951 | 0.443 | 0.600890052902075 | 0.490821286240141 | 0.561934876627864 | 0.941696908693733 | 0.829734761131295 | 0.880940844456856 | 0.246231694954624 | 2.55433624902191E-5 | 8.57039306780817E7 | 1.2308209015436E8 | 1.23973335952419E8 | 1.09050331614224E8 | 1.30109606828786E8 | 1.02692161896587E8 | 8.73473050095944E7 | 1.23031831133367E8 | 7.19147674496861E7 | 1.29238189237995E8 | 9.43248217623685E7 | 1.03859326412487E8 | 5.11249836753994E8 | 2.4676744393623E8 | 2.01230291385254E8 | |
| Cont_P35908 | Keratin, type II cytoskeletal 2 epidermal OS=Homo sapiens OX=9606 GN=KRT2 PE=1 SV=2 | 284.975 | 78 | 42 | 1022 | 32 | 639 | 65.4 | cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes | plasma membrane;cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;cytoskeletal activity | 3849 | ENSG00000172867 | KRT2 | hsa:3849; P35908; Q4VAQ2 | Formation of the cornified envelope | 0.827 | 0.688 | 1.032 | 1.836 | 1.146 | 1.306 | 2.733 | 0.542 | 0.499413631103761 | 0.411258958244596 | 0.544106843431104 | 0.933570718645937 | 0.912218866069753 | 0.862063111456553 | 0.309041843038519 | 2.9837536993241E-4 | 2.56957016834685E7 | 6.51011422173888E7 | 5.25056794690703E7 | 3.16465014359267E7 | 4.04662454773149E7 | 3.03458785296059E7 | 2.58420950665494E7 | 4.44581259999837E7 | 1.77732081549674E7 | 3.88601529372083E7 | 2.41897353529024E7 | 4.54682916268081E7 | 9.79668081708945E7 | 6.73715830359901E7 | 6.38856203067551E7 | |
| Q62059 | Versican core protein [OS=Mus musculus] | 279.715 | 17 | 44 | 1073 | 44 | 3357 | 366.6 | cell adhesion;developmental processes | non-structural extracellular;extracellular matrix;other cell component | other molecular function | Vcan | Q62058; Q62059; Q9CUU0 | ECM proteoglycans; Glycosaminoglycan-protein linkage region biosynthesis; CS/DS degradation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; CS-GAG biosynthesis; DS-GAG biosynthesis | 20 | 20 | 20 | 20 | 1.005 | 1.018 | 0.536 | 1.805 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.854305439376382 | 0.613304974369123 | 0.478009151463064 | 0.783304059803245 | 125473.726574878 | 146060.097046071 | 41031.8651630982 | 8.44868881898379E7 | 1.01917408783468E8 | 9.76252353450265E7 | 1.00104936351016E8 | 8.17450473009677E7 | 8.92610512588614E7 | 1.04839173391366E8 | 1.06605513712809E8 | 7.38631920533055E7 | 5.09261453344577E7 | 4.44571187520766E7 | 8.14544543672178E7 | |||
| P10493 | Nidogen-1 [OS=Mus musculus] | 275.191 | 43 | 42 | 852 | 42 | 1245 | 136.5 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | other molecular function | 18073 | ENSMUSG00000005397 | Nid1 | mmu:18073; P10493; Q3TKX9; Q8BQI3; Q8C3U8; Q8C9P6 | Laminin interactions; Degradation of the extracellular matrix | 20 | 20 | 12.26 | 6.185 | 0.272 | 1.009 | 0.083 | 3.135 | 1.65082956259427E-17 | 1.8644578313253E-17 | 0.251140212279038 | 0.461941385639594 | 0.013229256333524 | 0.604382524464811 | 1.0740690550749E-5 | 0.781368126060588 | 439897.722361698 | 266111.080129006 | 261357.080833752 | 1.30583493944604E8 | 1.41493313555848E8 | 1.08068734992402E8 | 1.1764867041349E8 | 1.23903817347262E8 | 1.22059347123012E8 | 3.85653673006923E7 | 3.40794335543811E7 | 2.32700802472122E7 | 8950100.03941293 | 6809358.71273179 | 1.16807558295498E7 | |
| O88207 | Collagen alpha-1(V) chain [OS=Mus musculus] | 275.025 | 46 | 52 | 413 | 44 | 1838 | 183.6 | cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes | extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12831 | ENSMUSG00000026837 | Col5a1 | A3KGE3; mmu:12831; O88207; Q3UG94; Q6F6B0 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | ECM proteoglycans; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; MET activates PTK2 signaling | 20 | 20 | 11.658 | 8.419 | 0.482 | 2.145 | 0.446 | 1.84 | 1.65082956259427E-17 | 1.8644578313253E-17 | 0.268653947705267 | 0.311207075116757 | 0.189625712887896 | 0.848119069115724 | 0.302671730722046 | 0.809503222445875 | 12502.6007438316 | 105962.872602761 | 122701.039249758 | 8585864.47184676 | 9052435.86465399 | 8047799.6262338 | 3715509.90739661 | 3183478.03245453 | 3834509.14396516 | 3548034.64380386 | 3694879.64301103 | 2052789.86607006 | 1322438.93167649 | 910135.702053452 | 1926767.56075777 |
| P37889 | Fibulin-2 [OS=Mus musculus] | 269.894 | 43 | 37 | 791 | 37 | 1221 | 131.7 | other biological processes | non-structural extracellular | other molecular function | 14115 | ENSMUSG00000064080 | Fbln2 | G5E8B3; mmu:14115; P37889; Q9WUI2 | Molecules associated with elastic fibres | 20 | 9.095 | 14.207 | 9.595 | 0.657 | 1.229 | 0.44 | 1.856 | 1.65082956259427E-17 | 0.0640195441309023 | 0.201227492083465 | 0.255240026777032 | 0.453005417011507 | 0.803447472095846 | 0.290132264062119 | 0.809503222445875 | 404936.27628206 | 303410.824570497 | 379728.902265123 | 7.35240092421165E7 | 8.16716617206073E7 | 8.54486063918813E7 | 7.34239875271171E7 | 6.18846762513378E7 | 6.13955038440774E7 | 5.64407337496573E7 | 5.35180097543675E7 | 3.80873889057723E7 | 2.96696416762988E7 | 2.21115750486307E7 | 3.84218730879294E7 | |
| Q8VHX6 | Filamin-C [OS=Mus musculus] | 249.498 | 31 | 65 | 425 | 56 | 2726 | 290.9 | cell organization and biogenesis;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity | 68794 | ENSMUSG00000068699 | Flnc | B2RY80; B9EKT2; mmu:68794; Q6PAI6; Q8VHX6; Q9JJ38 | Cell-extracellular matrix interactions | 0.924 | 1.063 | 2.364 | 0.915 | 1.621 | 1.781 | 0.941 | 3.029 | 0.562594032195739 | 0.719627996749639 | 0.962331548063155 | 0.57290809187594 | 0.976873891151678 | 0.96786708205164 | 0.933437821008547 | 0.80954066750699 | 362673.376414211 | 453714.7830589 | 401875.758519269 | 2896613.16388353 | 1997446.07055639 | 1374740.24453431 | 898320.393102247 | 899851.262035181 | 1251187.76236098 | 4619845.64928082 | 4224920.76413233 | 4533386.9985568 | 889222.28002913 | 1245417.60281572 | 1275359.84004796 | |
| Q04857 | Collagen alpha-1(VI) chain [OS=Mus musculus] | 248.981 | 44 | 33 | 588 | 33 | 1025 | 108.4 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component | other molecular function | 12833 | ENSMUSG00000001119 | Col6a1 | mmu:12833; Q04857 | ECM proteoglycans; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Signaling by PDGF; NCAM1 interactions | 8.793 | 4.087 | 2.364 | 2.258 | 0.328 | 1.748 | 0.341 | 1.364 | 0.2534363617947 | 0.392208211277376 | 0.962331548063155 | 0.971216996811237 | 0.0353343473113635 | 0.97504218639442 | 0.115965329440656 | 0.380888676065133 | 99442.7570537982 | 67304.0023261046 | 63848.8638629308 | 6.50338448192604E7 | 8.11264443817216E7 | 6.12675161034549E7 | 5.28406132873544E7 | 4.53711044962942E7 | 5.19951028566589E7 | 2.08305860584001E7 | 2.24322225654869E7 | 1.63957751491443E7 | 1.39653990737858E7 | 1.00181099527419E7 | 1.94360212112643E7 | |
| Cont_Q2UVX4 | Complement C3 OS=Bos taurus OX=9913 GN=C3 PE=1 SV=2 | 247.154 | 39 | 55 | 851 | 47 | 1661 | 187.1 | cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular;other cell component | signal transduction activity or receptor binding;enzyme regulator activity | 280677 | ENSBTAG00000017280 | C3 | bta:280677; Q2KIZ4; Q2UVX4 | Complement and coagulation cascades; Complement activation, classical pathway | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Neutrophil degranulation; Peptide ligand-binding receptors; G alpha (i) signalling events; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade; Alternative complement activation; Activation of C3 and C5 | 1.019 | 1.197 | 1.097 | 0.804 | 1.068 | 0.796 | 0.594 | 1.431 | 0.615680953989958 | 0.798729234704005 | 0.573945385766997 | 0.506364847510615 | 0.87421335771164 | 0.291700662163587 | 0.591028379533681 | 0.448532796991499 | 1.66248121121728E7 | 1.69271139045693E7 | 1.05083515570206E7 | 1.25526666866144E7 | 1.76991579704635E7 | 1.56235874907449E7 | 1.80944158276855E7 | 1.82336027421103E7 | 1.90370193770683E7 | 1.87583360164926E7 | 1.78001813666833E7 | 1.18248646641963E7 | 8899645.14317005 | 9025681.5960692 | 1.79617171787325E7 |
| Q62261 | Spectrin beta chain, non-erythrocytic 1 [OS=Mus musculus] | 244.684 | 30 | 61 | 398 | 61 | 2363 | 274.1 | cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 20742 | ENSMUSG00000020315 | Sptbn1 | A2AFU1; mmu:20742; Q3TEM7; Q5SQL8; Q5SQL9; Q62261; Q9QWJ7 | COPI-mediated anterograde transport; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; RHOU GTPase cycle; Interaction between L1 and Ankyrins; RHOV GTPase cycle | 1.181 | 1.156 | 1.412 | 1.471 | 1.95 | 2.087 | 1.904 | 2.22 | 0.69394578118832 | 0.776437620310661 | 0.693719649766064 | 0.831411077141515 | 0.937876734191067 | 0.86315143463057 | 0.664971370235365 | 0.953305976192702 | 373834.445440549 | 533726.562973047 | 569801.107945045 | 3103526.47805657 | 3181731.16602619 | 2477755.42998989 | 796281.087102098 | 609431.872132576 | 1356947.15467432 | 7745784.08821259 | 6610112.71623617 | 4897418.35730506 | 2432765.02616441 | 1743474.26371724 | 2723698.32906552 | |
| Q640N1 | Adipocyte enhancer-binding protein 1 [OS=Mus musculus] | 239.707 | 38 | 34 | 648 | 34 | 1128 | 128.3 | protein metabolism;other biological processes | nucleus;other cell component | nucleic acid binding activity;other molecular function | 11568 | ENSMUSG00000020473 | Aebp1 | mmu:11568; O88442; Q3TVV5; Q3TWA7; Q3TX56; Q3TXB2; Q5NCI9; Q61281; Q640N1 | 8.459 | 10.223 | 5.53 | 4.478 | 0.703 | 1.165 | 0.36 | 2.258 | 0.269326617826563 | 0.0457359864845759 | 0.605387748357992 | 0.631359014803774 | 0.534291750451691 | 0.760992448481534 | 0.145805028390539 | 0.963436677882021 | 3560033.84712119 | 4696620.34449178 | 6275149.80645163 | 4.59930845855363E7 | 5.69735867783534E7 | 2.04646374454636E7 | 3.80233154774145E7 | 4.02615711999708E7 | 4.03854487434811E7 | 3.40966164303398E7 | 3.7490792004469E7 | 2.41166240785119E7 | 1.4983671743246E7 | 1.40971982755857E7 | 2.68643149803103E7 | ||
| P57780 | Alpha-actinin-4 [OS=Mus musculus] | 239.42 | 58 | 45 | 483 | 30 | 912 | 104.9 | cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes | cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 60595 | ENSMUSG00000054808 | Actn4 | mmu:60595; P57780 | Primary focal segmental glomerulosclerosis (FSGS) | Platelet degranulation | 20 | 20 | 20 | 11.478 | 1.18 | 2.264 | 1.041 | 2.59 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 0.19149089837131 | 0.921882153462399 | 0.795351011232032 | 0.968364585136618 | 0.938282411159324 | 5221.79731213346 | 36578.541519335 | 9107610.67207618 | 1.00453975465233E7 | 1.03378326393571E7 | 5095419.11923033 | 3409382.50707632 | 5238186.41277381 | 1.31020350186557E7 | 1.2711162036506E7 | 9162046.18669404 | 4501757.36231035 | 3002316.05426355 | 5816939.08777499 | |
| Q7TPR4 | Alpha-actinin-1 [OS=Mus musculus] | 235.529 | 54 | 42 | 511 | 27 | 892 | 103 | cell adhesion;cell organization and biogenesis;other biological processes | plasma membrane;other membranes;cytoskeleton;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function | 109711 | ENSMUSG00000015143 | Actn1 | mmu:109711; Q7TPR4 | Regulation of actin cytoskeleton; Integrin-mediated cell adhesion; Focal adhesion | Platelet degranulation ; RHOF GTPase cycle; RHOBTB2 GTPase cycle; RHOD GTPase cycle; Regulation of cytoskeletal remodeling and cell spreading by IPP complex components | 2.068 | 0.45 | 1.822 | 2.422 | 1.639 | 2.396 | 1.586 | 2.793 | 0.995554138371554 | 0.178726136005694 | 0.819280225722906 | 0.941696908693733 | 0.974207409660283 | 0.744084716394381 | 0.837231569641376 | 0.879972045955715 | 354073.059499792 | 209249.076355465 | 897084.460899514 | 5526121.35104279 | 6211867.70337129 | 6893436.45630869 | 2413615.48536692 | 1933168.81934458 | 3229981.90899851 | 1.03807818109957E7 | 1.11771340173328E7 | 8282960.99949337 | 3416305.89125481 | 2797115.44078374 | 4939050.64701654 |
| P02468 | Laminin subunit gamma-1 [OS=Mus musculus] | 230.882 | 35 | 43 | 454 | 43 | 1607 | 177.2 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | Lamc1 | P02468 | 13.572 | 7.288 | 7.506 | 4.094 | 0.559 | 2.029 | 0.482 | 2.135 | 0.118212047511996 | 0.116315527815218 | 0.459134305737471 | 0.675951294045723 | 0.3041568870489 | 0.877818946381645 | 0.368062651583427 | 0.922276466908065 | 14325.5972836352 | 21883.5466161272 | 1.5357350900924E7 | 1.57310961044729E7 | 1.74335709018572E7 | 7496762.71625721 | 6775968.90045745 | 7708775.93718172 | 9245241.37337628 | 9035989.05815721 | 5573559.97495901 | 2765122.91380764 | 2368540.67041914 | 4605215.17131646 | |||||
| Q91ZX7 | Prolow-density lipoprotein receptor-related protein 1 [OS=Mus musculus] | 230.497 | 15 | 57 | 519 | 56 | 4545 | 504.4 | other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;other molecular function | 16971 | Lrp1 | mmu:16971; Q61291; Q91ZX7; Q920Y4 | Statin pathway; Wnt signaling pathway | Scavenging of heme from plasma; Retinoid metabolism and transport | 20 | 13.648 | 18.208 | 13.235 | 0.805 | 1.902 | 0.692 | 2.078 | 1.65082956259427E-17 | 0.0181625429641231 | 0.133639440745791 | 0.150830220548111 | 0.687557067265551 | 0.925871264502428 | 0.74148782464906 | 0.901098484497789 | 10237.2255539891 | 51104.3489937616 | 6875342.47952318 | 6944806.90573824 | 8247481.69257335 | 4299652.1243919 | 2953538.60705284 | 3392031.85738558 | 6405748.2654286 | 5854087.4911046 | 4914685.84613499 | 2044471.2247951 | 1705219.62694462 | 2981142.11204421 | ||
| Cont_P60712 | Actin, cytoplasmic 1 OS=Bos taurus OX=9913 GN=ACTB PE=1 SV=1 | 225.45 | 70 | 19 | 852 | 2 | 375 | 41.7 | cell organization and biogenesis;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component | enzyme regulator activity;cytoskeletal activity;other molecular function | 100033878; 100135470; 100173832; 101844587; 102139853; 11461; 118833809; 280979; 396526; 403580; 414396; 443052; 450133; 60; 81822 | ENSBTAG00000026199; ENSCAFG00000016020; ENSCAFG00030015381; ENSCAFG00040015695; ENSCPOG00000013467; ENSG00000075624; ENSMAUG00000008763; ENSMUSG00000029580; ENSOARG00040012985; ENSOARG00180022443; ENSOARG00185023855; ENSOARG00215030140; ENSOARG00225009314; ENSPPYG00000017336; ENSPTRG00000018890; ENSRNOG00000034254; ENSSSCG00000007585; ENSSSCG00030003451; ENSSSCG00035038792; ENSSSCG00040049462; ENSSSCG00045027458; ENSSSCG00050065025; ENSSSCG00055012597; ENSSSCG00060019124; ENSSSCG00065037921; ENSSSCG00070011353; ENSSSCG00105030144; ENSSSCG00110026965; ENSSSCG00115013637; ENSSSCG00130033784 | Actb; ACTB | A5D961; A5PKA1; bta:280979; cfa:403580; cpoc:100135470; csab:103246953; ecb:100033878; gga:396526; hsa:60; maua:101844587; mmu:11461; O18840; oas:443052; P02570; P60706; P60707; P60708; P60709; P60710; P60711; P60712; P60713; P70514; P99021; pon:100173832; ptr:450133; Q11209; Q11211; Q3SZD2; Q3TI89; Q3TVP6; Q4L0Y2; Q4R561; Q5R1X3; Q5R582; Q5R6G0; Q64316; Q6QAQ1; Q6ZWM3; Q711N9; Q71FK5; Q75MN2; Q76N69; Q8MIJ0; Q8SPX4; Q95164; Q96B34; Q96HG5; rno:81822; ssc:414396 | FAS pathway and stress induction of HSP regulation; Actin cytoskeleton regulation; Myometrial relaxation and contraction pathways; Focal adhesion; Arrhythmogenic right ventricular cardiomyopathy; Pathogenic Escherichia coli infection; Common pathways underlying drug addiction; Myometrial relaxation and contraction pathways; Focal adhesion; Fas ligand pathway and stress induction of heat shock proteins; Pathogenic Escherichia coli infection; Arrhythmogenic right ventricular cardiomyopathy; Focal adhesion; Myometrial relaxation and contraction pathways; Regulation of actin cytoskeleton; Myometrial relaxation and contraction pathways; Ebola virus infection in host; Acute viral myocarditis; Thermogenesis; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Overlap between signal transduction pathways contributing to LMNA laminopathies; Pleural mesothelioma; Regulation of actin cytoskeleton; Network map of SARS-CoV-2 signaling; Regulation of actin cytoskeleton; Regulation of actin cytoskeleton; Focal adhesion | Formation of the canonical BAF (cBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); Regulation of actin dynamics for phagocytic cup formation; EPH-ephrin mediated repulsion of cells; Formation of annular gap junctions; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; RHO GTPases Activate Formins; RHOF GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; B-WICH complex positively regulates rRNA expression; Regulation of CDH1 Function; Formation of the dystrophin-glycoprotein complex (DGC); Formation of the canonical BAF (cBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); RHO GTPases Activate WASPs and WAVEs; UCH proteinases; DNA Damage Recognition in GG-NER; Formation of the non-canonical BAF (ncBAF) complex; RHO GTPases activate IQGAPs; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Cell-extracellular matrix interactions; MAP2K and MAPK activation; Interaction between L1 and Ankyrins; RHOF GTPase cycle; DNA Damage Recognition in GG-NER; MAP2K and MAPK activation; RHO GTPases Activate Formins; Clathrin-mediated endocytosis; UCH proteinases; RHOF GTPase cycle; DNA Damage Recognition in GG-NER; EPH-ephrin mediated repulsion of cells; VEGFA-VEGFR2 Pathway; Regulation of actin dynamics for phagocytic cup formation; Adherens junctions interactions; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); RHO GTPases Activate WASPs and WAVEs; B-WICH complex positively regulates rRNA expression; Regulation of CDH1 Function; EPHB-mediated forward signaling; Formation of the non-canonical BAF (ncBAF) complex; Formation of the canonical BAF (cBAF) complex; Formation of annular gap junctions; RHO GTPases activate IQGAPs; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; RHO GTPases Activate WASPs and WAVEs; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RHO GTPases activate IQGAPs; RHO GTPases Activate Formins; RHOF GTPase cycle; Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs); B-WICH complex positively regulates rRNA expression; Signaling by BRAF and RAF1 fusions; UCH proteinases; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; VEGFA-VEGFR2 Pathway; Formation of the dystrophin-glycoprotein complex (DGC); Factors involved in megakaryocyte development and platelet production; Regulation of MITF-M-dependent genes involved in pigmentation; Formation of the canonical BAF (cBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); EPH-ephrin mediated repulsion of cells; HATs acetylate histones; Interaction between L1 and Ankyrins; Prefoldin mediated transfer of substrate to CCT/TriC; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Adherens junctions interactions; Regulation of CDH1 Function; Formation of the non-canonical BAF (ncBAF) complex; DNA Damage Recognition in GG-NER; Formation of the polybromo-BAF (pBAF) complex; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Formation of annular gap junctions; Folding of actin by CCT/TriC; Cell-extracellular matrix interactions; MAP2K and MAPK activation; RHO GTPases Activate Formins; Recycling pathway of L1; RHO GTPases activate IQGAPs; Clathrin-mediated endocytosis; Formation of the dystrophin-glycoprotein complex (DGC); EPHB-mediated forward signaling; UCH proteinases; B-WICH complex positively regulates rRNA expression; Adherens junctions interactions; Formation of the non-canonical BAF (ncBAF) complex; Formation of annular gap junctions; Formation of the polybromo-BAF (pBAF) complex; VEGFA-VEGFR2 Pathway; Cell-extracellular matrix interactions; RHO GTPases Activate WASPs and WAVEs; Regulation of CDH1 Function; Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; UCH proteinases; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); Formation of the polybromo-BAF (pBAF) complex; B-WICH complex positively regulates rRNA expression; DNA Damage Recognition in GG-NER; Formation of the canonical BAF (cBAF) complex; RHO GTPases Activate Formins; Regulation of CDH1 Function; Interaction between L1 and Ankyrins; RHOF GTPase cycle; Formation of the non-canonical BAF (ncBAF) complex; Adherens junctions interactions; Formation of the dystrophin-glycoprotein complex (DGC); VEGFA-VEGFR2 Pathway; RHO GTPases Activate WASPs and WAVEs; Cell-extracellular matrix interactions; EPHB-mediated forward signaling; MAP2K and MAPK activation; Recycling pathway of L1; RHO GTPases activate IQGAPs; Formation of annular gap junctions; B-WICH complex positively regulates rRNA expression; UCH proteinases; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); MAP2K and MAPK activation; Formation of the polybromo-BAF (pBAF) complex; RHO GTPases Activate Formins; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases Activate WASPs and WAVEs; Formation of the dystrophin-glycoprotein complex (DGC); VEGFA-VEGFR2 Pathway; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; DNA Damage Recognition in GG-NER; RHOF GTPase cycle; Cell-extracellular matrix interactions; Adherens junctions interactions; Formation of the non-canonical BAF (ncBAF) complex; Formation of the canonical BAF (cBAF) complex; RHO GTPases activate IQGAPs; Regulation of CDH1 Function; Gap junction degradation; Formation of annular gap junctions; Regulation of actin dynamics for phagocytic cup formation; RHOF GTPase cycle; Clathrin-mediated endocytosis; RHO GTPases Activate Formins; Cell-extracellular matrix interactions; VEGFA-VEGFR2 Pathway; Adherens junctions interactions; RHO GTPases activate IQGAPs; UCH proteinases; EPHB-mediated forward signaling; MAP2K and MAPK activation; RHO GTPases Activate WASPs and WAVEs; Formation of the dystrophin-glycoprotein complex (DGC); Formation of annular gap junctions; Formation of the canonical BAF (cBAF) complex; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of the non-canonical BAF (ncBAF) complex; Regulation of CDH1 Function | 20 | 20 | 20 | 20 | 1.785 | 1.645 | 1.193 | 2.594 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.946568086066385 | 0.994348552930242 | 0.963278515868644 | 0.938282411159324 | 1924782.99006244 | 2098949.09709163 | 1966246.27612296 | 6.9333476629433E7 | 7.92679608662888E7 | 4.66219167617927E7 | 4.31411746831055E7 | 4.48147974340301E7 | 5.69102455002969E7 | 1.21577893646273E8 | 1.207324829685E8 | 8.72162161647777E7 | 5.58171302270344E7 | 3.75040107769213E7 | 6.67519874410893E7 |
| P63260 | Actin, cytoplasmic 2 [OS=Mus musculus] | 217.791 | 70 | 19 | 831 | 2 | 375 | 41.8 | cell organization and biogenesis;stress response;developmental processes;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 11465 | ENSMUSG00000062825 | Actg1 | mmu:11465; P02571; P14104; P63260; P99022 | Myometrial relaxation and contraction pathways; Regulation of actin cytoskeleton; Focal adhesion | Platelet degranulation ; RHO GTPases activate IQGAPs; Adherens junctions interactions; Regulation of CDH1 Function; RHO GTPases Activate Formins; Regulation of actin dynamics for phagocytic cup formation; Interaction between L1 and Ankyrins; MAP2K and MAPK activation; Recycling pathway of L1; Clathrin-mediated endocytosis; Formation of the dystrophin-glycoprotein complex (DGC); EPHB-mediated forward signaling; RHOF GTPase cycle; Formation of annular gap junctions; VEGFA-VEGFR2 Pathway; Cell-extracellular matrix interactions; RHO GTPases Activate WASPs and WAVEs; RHOBTB2 GTPase cycle | 20 | 20 | 20 | 20 | 1 | 1.401 | 0.685 | 1.853 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.85271451854395 | 0.901789796153066 | 0.731487178650893 | 0.819844267712751 | 345218.530665522 | 243712.893345201 | 175067.879334021 | 138179.400499307 | 114235.784978709 | 184680.44906409 | 283414.957020267 | 357431.419092683 | 129167.257177683 | 191405.076269325 | 47386.9835565671 | 139954.449837086 | |||
| P33434 | 72 kDa type IV collagenase [OS=Mus musculus] | 212.03 | 56 | 30 | 889 | 30 | 662 | 74.1 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes | extracellular matrix;plasma membrane;other membranes;cytoskeleton;mitochondrion;nucleus;other cell component | other molecular function | 17390 | ENSMUSG00000031740 | Mmp2 | mmu:17390; P33434 | Lung fibrosis; IL-3 signaling pathway; Matrix metalloproteinases | Collagen degradation; Extra-nuclear estrogen signaling; EPH-ephrin mediated repulsion of cells; Activation of Matrix Metalloproteinases | 6.722 | 1.555 | 9.726 | 3.89 | 1.512 | 3.012 | 2.621 | 1.842 | 0.372996577396536 | 0.964209443670126 | 0.342075680986172 | 0.708142491896103 | 0.993994198406889 | 0.459747209584207 | 0.34519376377552 | 0.809503222445875 | 1.45817945044039E7 | 3.99854546791863E7 | 2.31586213408419E7 | 6.16168347215595E7 | 6.71128653428481E7 | 5.47627512450794E7 | 2.153095933586E7 | 2.04088973517033E7 | 2.1514079157928E7 | 9.59427020238632E7 | 8.49468673692442E7 | 8.11217362792938E7 | 5.65046943814106E7 | 3.5725700482165E7 | 6.85636819548367E7 |
| P19096 | Fatty acid synthase [OS=Mus musculus] | 203.372 | 23 | 48 | 335 | 48 | 2504 | 272.3 | other metabolic processes;stress response;other biological processes | plasma membrane;other membranes;cytosol;ER/Golgi;other cell component | other molecular function | 14104 | ENSMUSG00000025153 | Fasn | B1ATU8; mmu:14104; P19096; Q6PB72; Q8C4Z0; Q9EQR0 | Fatty acid biosynthesis; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-9 fatty acid synthesis; Elongation of (very) long chain fatty acids | Fatty acyl-CoA biosynthesis; Vitamin B5 (pantothenate) metabolism | 3.919 | 2.111 | 2.319 | 4.668 | 1.067 | 1.669 | 0.698 | 2.417 | 0.66189768147619 | 0.847457711018997 | 0.951921622352553 | 0.605074788683686 | 0.87421335771164 | 0.994834213681465 | 0.746782404466558 | 0.990873516209569 | 48161.514825801 | 157425.136778521 | 3018838.26514359 | 3331564.42510829 | 1838171.31939824 | 1125050.80259593 | 1067574.24276956 | 1976727.22395058 | 3354008.01034064 | 3348654.9716265 | 2283763.91979924 | 908323.020723558 | 618361.207888453 | 1151575.74161029 | |
| Cont_Q3SZ57 | Alpha-fetoprotein OS=Bos taurus OX=9913 GN=AFP PE=2 SV=1 | 202.89 | 62 | 30 | 1153 | 29 | 610 | 68.5 | other metabolic processes;developmental processes;other biological processes | non-structural extracellular;other cell component | other molecular function | 506011 | ENSBTAG00000017131 | AFP | bta:506011; Q3SZ57 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 0.89 | 1.253 | 1.171 | 0.883 | 1.251 | 0.689 | 0.666 | 1.305 | 0.540832988168188 | 0.82964085881652 | 0.605387748357992 | 0.553772240900005 | 0.938859506774495 | 0.15729598575093 | 0.699570390946254 | 0.323545662226049 | 4.4629857016799E7 | 4.39639700572647E7 | 2.72178105183923E7 | 3.15168703669999E7 | 4.26075077823651E7 | 3.4328683389093E7 | 4.8541823037709E7 | 4.32960721364381E7 | 4.4115949306695E7 | 4.61564880446121E7 | 4.7548077639711E7 | 3.504265434565E7 | 2.7823391939759E7 | 3.01476017178829E7 | 5.24042356620578E7 | |
| P48678 | Prelamin-A/C [OS=Mus musculus] | 202.607 | 60 | 37 | 529 | 36 | 665 | 74.2 | cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes | other membranes;cytoskeleton;nucleus;other cell component | other molecular function | 16905 | ENSMUSG00000028063 | Lmna | B3RH23; B3RH24; mmu:16905; P11516; P48678; P97859; Q3TIH0; Q3TTS8; Q3U733; Q3U7I5; Q3UCA0; Q3UCJ8; Q3UCU3; Q91WF2; Q9DC21 | Adipogenesis genes; FAS pathway and stress induction of HSP regulation | 20 | 17.997 | 17.767 | 20 | 4.584 | 2.32 | 1.381 | 7.656 | 1.65082956259427E-17 | 0.00670345592293191 | 0.139423967594304 | 1.70336894001643E-17 | 0.236076921565588 | 0.77212820363828 | 0.901149690306505 | 0.00692305873191716 | 56886.7483713492 | 69336.1384695612 | 100943.444664856 | 1.29312831685903E7 | 1.22006597313063E7 | 8045013.512583 | 3337288.2268023 | 3262868.75019265 | 5804803.63611667 | 6.75536277126862E7 | 5.59333072922179E7 | 3.75993669940438E7 | 7422846.33935557 | 4234323.21548912 | 7210898.93259597 | |
| Q02788 | Collagen alpha-2(VI) chain [OS=Mus musculus] | 202.37 | 41 | 36 | 585 | 36 | 1034 | 110.3 | cell adhesion;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component | other molecular function | 12834 | ENSMUSG00000020241 | Col6a2 | mmu:12834; Q02788; Q05505; Q8C972; Q8K229 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | ECM proteoglycans; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation | 10.956 | 20 | 5.246 | 3.501 | 0.458 | 1.362 | 0.325 | 1.848 | 0.175734701097799 | 1.8644578313253E-17 | 0.633123216104285 | 0.767312384697355 | 0.156641881403766 | 0.880899056945259 | 0.0961283818482991 | 0.809503222445875 | 66343.4096791777 | 224638.480326659 | 72730.0086108415 | 5.06665581594054E7 | 6.05623117299827E7 | 4.51585075606234E7 | 4.3575871784427E7 | 3.72580130101725E7 | 4.32608904810994E7 | 2.4375983761655E7 | 2.22548052919965E7 | 1.51565723805374E7 | 1.09937351728106E7 | 7758608.50160191 | 1.64425759910943E7 |
| P97927 | Laminin subunit alpha-4 [OS=Mus musculus] | 199.33 | 30 | 41 | 409 | 41 | 1816 | 201.7 | cell adhesion;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | signal transduction activity or receptor binding | 16775 | ENSMUSG00000019846 | Lama4 | mmu:16775; O88785; P70409; P97927; Q14BF2 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Formation of the dystrophin-glycoprotein complex (DGC); Laminin interactions; MET activates PTK2 signaling | 5.298 | 2.886 | 2.789 | 3.143 | 0.574 | 1.89 | 0.55 | 1.892 | 0.496649188935323 | 0.645007535999596 | 0.952104483873957 | 0.825047045401531 | 0.329011090732691 | 0.929291541980042 | 0.50594120050135 | 0.819844267712751 | 540030.170801593 | 370746.050286439 | 259459.878107817 | 8261193.64464048 | 1.06712284071143E7 | 1.21929154576081E7 | 5309597.35327991 | 4688186.1422195 | 5379156.74886131 | 6459712.32980478 | 5951943.81149588 | 4870147.4483696 | 2541823.46940274 | 2775962.47504545 | 3878847.28463652 |
| P20152 | Vimentin [OS=Mus musculus] | 183.446 | 60 | 29 | 762 | 27 | 466 | 53.7 | cell organization and biogenesis;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component | cytoskeletal activity;nucleic acid binding activity;other molecular function | 22352 | ENSMUSG00000026728 | Vim | mmu:22352; O08704; P20152; Q8CCH1 | Spinal cord injury; Primary focal segmental glomerulosclerosis (FSGS); Alpha 6 beta 4 integrin signaling pathway | Aggrephagy; Striated Muscle Contraction; Caspase-mediated cleavage of cytoskeletal proteins; RHOBTB1 GTPase cycle | 20 | 7.872 | 20 | 13.938 | 2.257 | 5.309 | 1.573 | 6.359 | 1.65082956259427E-17 | 0.0955146622024883 | 1.50457038391225E-17 | 0.137621774180062 | 0.873609880131656 | 0.0297998664849654 | 0.840672080806375 | 0.0332723373064956 | 573727.34417641 | 968981.536762911 | 1794707.43115169 | 4.14069582585024E7 | 3.33312643886138E7 | 2.54656192896882E7 | 6941733.99810384 | 6173483.46835617 | 8980531.63051753 | 8.80704815958352E7 | 8.07026224155391E7 | 5.51524218564722E7 | 1.5029979690535E7 | 6861556.37440952 | 1.68923991921504E7 |
| Q64727 | Vinculin [OS=Mus musculus] | 182.753 | 50 | 45 | 419 | 45 | 1066 | 116.6 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | plasma membrane;other membranes;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 22330 | ENSMUSG00000021823 | Vcl | mmu:22330; Q64727; Q8BP32; Q8BS46; Q922C5; Q922D9 | Primary focal segmental glomerulosclerosis (FSGS); IL-3 signaling pathway; Regulation of actin cytoskeleton; Integrin-mediated cell adhesion; Focal adhesion | Neutrophil degranulation; High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells; Platelet degranulation ; MAP2K and MAPK activation; Smooth Muscle Contraction; Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells; Regulation of CDH1 Function | 9.889 | 5.909 | 12.691 | 5.698 | 1.39 | 2.026 | 1.158 | 2.519 | 0.208404050858596 | 0.190838415616571 | 0.238791978742132 | 0.504745711776551 | 0.964629994744883 | 0.878264980963866 | 0.977491813528386 | 0.958518237573655 | 199164.849916128 | 87100.0128702587 | 92185.322880836 | 5675245.0989599 | 5838625.66584249 | 3008640.49360623 | 1870082.63283096 | 1414114.90526218 | 2577750.73562883 | 7844023.43396073 | 7226639.25078312 | 5204108.91618431 | 2343388.9049214 | 1587883.53032107 | 3146179.30802337 |
| Q8K4G1 | Latent-transforming growth factor beta-binding protein 4 [OS=Mus musculus] | 180.216 | 27 | 29 | 318 | 29 | 1666 | 178.5 | cell-cell signaling;cell organization and biogenesis;transport;signal transduction | non-structural extracellular;extracellular matrix | other molecular function | 108075 | ENSMUSG00000040488 | Ltbp4 | E9QPD9; mmu:108075; Q8K4G0; Q8K4G1 | TGF-beta receptor signaling activates SMADs; Molecules associated with elastic fibres | 7.729 | 4.292 | 20 | 12.27 | 2.67 | 1.52 | 1.837 | 2.119 | 0.308350896322176 | 0.362779483059131 | 1.50457038391225E-17 | 0.170566190602959 | 0.775297640004946 | 0.958956615096849 | 0.703189639676216 | 0.915193515309545 | 20541.0495723262 | 79596.1275426221 | 2657106.34177438 | 3398147.96764637 | 1365787.73467607 | 1578272.63307431 | 1205878.60177515 | 1625778.79640944 | 7998382.13678965 | 8274900.61088866 | 5600614.51816097 | 3209012.09868788 | 1154237.54308251 | 3609675.59166937 | ||
| Q68FD5 | Clathrin heavy chain 1 [OS=Mus musculus] | 180.117 | 32 | 43 | 363 | 43 | 1675 | 191.4 | cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes | plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component | nucleic acid binding activity;other molecular function | 67300 | ENSMUSG00000047126 | Cltc | mmu:67300; Q68FD5 | IL-7 signaling pathway; Kit receptor signaling pathway | MHC class II antigen presentation; Recycling pathway of L1; Cargo recognition for clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis; LDL clearance; Retrograde neurotrophin signalling; Formation of annular gap junctions; Lysosome Vesicle Biogenesis; WNT5A-dependent internalization of FZD4; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation; RHOU GTPase cycle; RHOV GTPase cycle | 6.05 | 5.808 | 20 | 6.768 | 2.931 | 1.275 | 1.251 | 2.935 | 0.4248536990637 | 0.198232028950426 | 1.50457038391225E-17 | 0.413413145615294 | 0.688274955487563 | 0.840666598828607 | 0.946476383814868 | 0.835383236382767 | 19752.350121194 | 9410.067942265 | 2001079.20697008 | 2709198.63758679 | 1592899.41627153 | 1121542.74388673 | 1205380.43272811 | 1952895.490984 | 7620271.96644723 | 6531411.29627789 | 6339405.19264676 | 2211269.42731124 | 1288866.59437226 | 2734753.66820203 | |
| P02469 | Laminin subunit beta-1 [OS=Mus musculus] | 179.863 | 27 | 40 | 429 | 39 | 1786 | 197 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;nucleus;other cell component | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 16777 | ENSMUSG00000002900 | Lamb1 | E9PXZ9; P02469 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Inflammatory response pathway; Alpha 6 beta 4 integrin signaling pathway; Focal adhesion | 9.979 | 4.434 | 6.526 | 2.693 | 0.537 | 1.97 | 0.475 | 2.435 | 0.205801242418232 | 0.341417478664423 | 0.526489846375643 | 0.891178501081124 | 0.269583968882479 | 0.900334730044572 | 0.356773085915651 | 0.98779298590131 | 1.07332672254E7 | 1.09845016908001E7 | 9663847.07936098 | 1.70142446901215E7 | 1.73820787777271E7 | 2.08268192848537E7 | 1.23074043806854E7 | 1.3842748821146E7 | 1.68288599063313E7 | 1.20697658178524E7 | 1.33872705970957E7 | 9031275.37365186 | 2.12878061302996E7 | 2.54341447554609E7 | 1.6513199650281E7 | |
| Q01853 | Transitional endoplasmic reticulum ATPase [OS=Mus musculus] | 179.055 | 52 | 32 | 411 | 32 | 806 | 89.3 | cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;other biological processes | other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;enzyme regulator activity;other molecular function | 269523 | ENSMUSG00000028452 | Vcp | mmu:269523; Q01853; Q3TFH9; Q3TIM2; Q3TXN9; Q6PI18; Q8BSR6; Q8CEG4 | IL-9 signaling pathway | RHOH GTPase cycle; Neutrophil degranulation; Protein methylation; Ovarian tumor domain proteases; Neddylation; ABC-family proteins mediated transport; Translesion Synthesis by POLH; Hedgehog ligand biogenesis; KEAP1-NFE2L2 pathway; HSF1 activation; N-glycan trimming in the ER and Calnexin/Calreticulin cycle; Josephin domain DUBs | 1.775 | 2.885 | 1.782 | 1.945 | 1.345 | 2.036 | 0.893 | 3.238 | 0.915230778358139 | 0.645007535999596 | 0.808626104853287 | 0.953867932777128 | 0.953038161729767 | 0.877818946381645 | 0.901149690306505 | 0.737824045087029 | 462345.280919521 | 876653.458620268 | 526426.850526767 | 1.01571081063743E7 | 9889323.38925712 | 7942233.31155878 | 4702185.44070802 | 4580279.55870278 | 6732778.24078372 | 1.50535993864462E7 | 1.350776734351E7 | 9751498.62422888 | 4128956.06599177 | 3881002.94215154 | 5380991.32313934 |
| Q03350 | Thrombospondin-2 [OS=Mus musculus] | 178.303 | 35 | 30 | 328 | 29 | 1172 | 129.8 | cell adhesion;other biological processes | non-structural extracellular;extracellular matrix;other cell component | other molecular function | 21826 | ENSMUSG00000023885 | Thbs2 | mmu:21826; Q03350; Q8CG21 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Signaling by PDGF; O-glycosylation of TSR domain-containing proteins | 0.722 | 1.325 | 0.917 | 0.852 | 0.905 | 1.968 | 0.612 | 3.033 | 0.425958502904743 | 0.861805134687803 | 0.49027994509233 | 0.535702081245677 | 0.792896707923278 | 0.900334730044572 | 0.620448351319483 | 0.80954066750699 | 2258622.92192986 | 2382783.54746756 | 1148078.18193404 | 1.31796330485542E7 | 1.5104624453426E7 | 5024405.63191042 | 7531099.32555027 | 7013388.1367688 | 7773703.92822199 | 1.11743686938308E7 | 1.16923792648853E7 | 8892616.7561804 | 4798999.04450137 | 2163159.37338424 | 5673668.48605754 |
| Q80YX1 | Tenascin [OS=Mus musculus] | 175.9 | 28 | 43 | 191 | 43 | 2110 | 231.7 | cell adhesion;cell-cell signaling;cell organization and biogenesis;stress response;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | signal transduction activity or receptor binding;other molecular function | 21923 | ENSMUSG00000028364 | Tnc | mmu:21923; Q64706; Q80YX1; Q80YX2 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Integrin cell surface interactions; ECM proteoglycans; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 13.594 | 2.194 | 1.128 | 0.769 | 0.051 | 7.209 | 0.207 | 1.299 | 0.117980756369098 | 0.827773046590747 | 0.560799429150649 | 0.474732236495646 | 1.08858887903907E-8 | 0.00280630917527262 | 0.00972980877962454 | 0.46732263590517 | 11007.0641239407 | 22426.4186578027 | 29153.7668969926 | 1.62969685459921E7 | 1.53776908456905E7 | 4644794.12302626 | 1608421.63729791 | 1232799.46655266 | 1507622.18059477 | 244493.865771831 | 206768.885305398 | 181767.385360463 | 119126.026959952 | 48104.5148614081 | 121500.029653831 |
| Q61147 | Ceruloplasmin [OS=Mus musculus] | 175.43 | 36 | 33 | 380 | 33 | 1061 | 121.1 | cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular | other molecular function | 12870 | ENSMUSG00000003617 | Cp | mmu:12870; Q61147; Q6P5C8 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Iron uptake and transport; Metal ion SLC transporters | 20 | 11.915 | 12.922 | 6.069 | 0.422 | 1.96 | 0.402 | 1.911 | 1.65082956259427E-17 | 0.0286042496128814 | 0.232756100865398 | 0.470567140616547 | 0.114472406028442 | 0.902824569867946 | 0.217345018530886 | 0.830251457557488 | 174325.913751449 | 58856.3090021062 | 115033.849364799 | 9557281.19120236 | 1.04767827169696E7 | 8762702.67228452 | 5461844.00566682 | 4018732.98956624 | 4629071.77649001 | 4355240.25919752 | 3723693.63350954 | 2684226.57769155 | 1556963.66647869 | 1720243.51649846 | 1992732.45731179 | |
| Q3UQ28 | Peroxidasin homolog [OS=Mus musculus] | 173.636 | 35 | 39 | 366 | 39 | 1475 | 165 | cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes | extracellular matrix;ER/Golgi;other cell component | extracellular structural activity;other molecular function | 69675 | ENSMUSG00000020674 | Pxdn | A4FU83; E9QNQ9; mmu:69675; Q3UQ28 | Crosslinking of collagen fibrils | 13.369 | 5.796 | 7.187 | 4.304 | 0.633 | 2.558 | 0.614 | 2.684 | 0.121749369203589 | 0.199060935853007 | 0.481687712882875 | 0.64860195920101 | 0.414844709855988 | 0.680311384167738 | 0.622521206052951 | 0.910753558746772 | 41306.9360165718 | 84058.3874627107 | 31201.070658041 | 9910595.89492489 | 1.28240532958945E7 | 7690537.3381544 | 3188445.14026578 | 3418561.86158515 | 3797799.58981602 | 6834484.53714744 | 5848987.74573488 | 4912888.48741006 | 1858779.55214279 | 743355.386480967 | 2642059.33003837 | |
| Q61316 | Heat shock 70 kDa protein 4 [OS=Mus musculus] | 169.044 | 48 | 31 | 300 | 31 | 841 | 94.1 | protein metabolism;other metabolic processes | other cell component | other molecular function | Hspa4 | Q61316 | Regulation of HSF1-mediated heat shock response | 3.829 | 1.513 | 4.49 | 1.286 | 1.217 | 1.907 | 0.903 | 2.909 | 0.675982462193546 | 0.947627746595709 | 0.704651587991194 | 0.760498481134506 | 0.937908804051419 | 0.922660568001848 | 0.905946265571965 | 0.842404289073844 | 22434.4697799145 | 118934.685179003 | 13120.5332518918 | 3090247.7626811 | 3632683.19217962 | 4934376.07998548 | 1752659.26658268 | 1094548.72984359 | 2299362.24833368 | 6254897.5603188 | 4282912.67963475 | 3832568.37667092 | 1209098.21921722 | 1139246.15986255 | 2002609.64313824 | |||
| Cont_P02533 | Keratin, type I cytoskeletal 14 OS=Homo sapiens OX=9606 GN=KRT14 PE=1 SV=4 | 164.831 | 58 | 26 | 684 | 9 | 472 | 51.5 | cell organization and biogenesis;other biological processes | plasma membrane;cytosol;cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 3861 | ENSG00000186847 | KRT14 | hsa:3861; P02533; Q14715; Q53XY3; Q9BUE3; Q9UBN2; Q9UBN3; Q9UCY4 | Corticotropin-releasing hormone signaling | Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin; Developmental Lineage of Mammary Gland Myoepithelial Cells; Type I hemidesmosome assembly | 1.494 | 1.366 | 1.328 | 2.74 | 0.843 | 1.136 | 1.961 | 0.518 | 0.821333803243143 | 0.880930298968675 | 0.666244110962191 | 0.887279041944908 | 0.735573385767802 | 0.728871118050286 | 0.645534074006669 | 1.76226512549596E-4 | 6033554.14310828 | 6671959.15781397 | 7782964.06135275 | 8837829.92566611 | 1.15627425945257E7 | 9278023.72116937 | 1.41062299354562E7 | 8950994.20838312 | 7841743.81261716 | 1.15454726530467E7 | 7260451.91646668 | 9574113.2223773 | 5.39893889957522E7 | 2.05703168301172E7 | 1.34402077310531E7 |
| P11499 | Heat shock protein HSP 90-beta [OS=Mus musculus] | 164.719 | 50 | 29 | 532 | 19 | 724 | 83.2 | cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component | enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function | 15516 | ENSMUSG00000023944 | Hsp90ab1 | mmu:15516; O89078; P11499; Q3UIQ7 | Focal adhesion: PI3K-Akt-mTOR signaling pathway | Neutrophil degranulation; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of actin dynamics for phagocytic cup formation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Attenuation phase; Estrogen-dependent gene expression; Sema3A PAK dependent Axon repulsion; Aryl hydrocarbon receptor signalling; DDX58/IFIH1-mediated induction of interferon-alpha/beta; HSF1 activation; RHOBTB2 GTPase cycle; The NLRP3 inflammasome | 20 | 20 | 20 | 20 | 1.344 | 3.198 | 1.054 | 3.873 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.952333191127893 | 0.385192173946943 | 0.975071223710592 | 0.476079393565723 | 221410.585638305 | 129165.68527882 | 147525.692220339 | 3.34627647115336E7 | 3.61961534999558E7 | 2.61391308788083E7 | 9541203.16877468 | 9273367.56835581 | 1.36082703259873E7 | 4.57710434253974E7 | 4.37708354854306E7 | 3.73056416942256E7 | 1.17622035416132E7 | 7437513.65495311 | 1.56244060515822E7 |
| Q9JKF1 | Ras GTPase-activating-like protein IQGAP1 [OS=Mus musculus] | 163.926 | 28 | 36 | 250 | 36 | 1657 | 188.6 | cell organization and biogenesis;developmental processes;signal transduction;other biological processes | plasma membrane;other membranes;cytoskeleton;nucleus;other cell component | enzyme regulator activity;other molecular function | 29875 | ENSMUSG00000030536 | Iqgap1 | G3UW45; mmu:29875; Q9JKF1 | G13 signaling pathway; Regulation of actin cytoskeleton | RHO GTPases activate IQGAPs; Neutrophil degranulation; RAC1 GTPase cycle; RAC2 GTPase cycle; RHOA GTPase cycle; MAP2K and MAPK activation; RHOQ GTPase cycle; RHOC GTPase cycle; RHOU GTPase cycle; RHOV GTPase cycle; Nephrin family interactions | 2.389 | 1.188 | 3.792 | 2.098 | 2.451 | 1.85 | 1.692 | 2.634 | 0.930229675308081 | 0.794460986683881 | 0.787568130909409 | 0.991639536226218 | 0.830676695521175 | 0.941920360687835 | 0.777195460870953 | 0.924682711624237 | 49243.316732893 | 68725.418758499 | 969026.209101501 | 1404075.03080168 | 833592.785314498 | 204266.486982725 | 334218.990287697 | 455010.844725875 | 4213732.69874793 | 3933999.53801573 | 3238797.72524118 | 860307.289081776 | 503563.00444482 | 1468565.36197421 | |
| P52480 | Pyruvate kinase PKM [OS=Mus musculus] | 163.393 | 62 | 27 | 442 | 27 | 531 | 57.8 | cell organization and biogenesis;other metabolic processes;other biological processes | cytosol;ER/Golgi;nucleus;other cell component | nucleic acid binding activity;kinase activity;other molecular function | 18746 | ENSMUSG00000032294 | Pkm | mmu:18746; P52480; Q3TBV8; Q3TBW5; Q3TC59; Q3U1X3; Q3U5P6; Q4VC20; Q64484; Q91YI8; Q9CWB1 | Glycolysis and gluconeogenesis; Purine metabolism | Neutrophil degranulation; Pyruvate metabolism; Glycolysis; Regulation of pyruvate metabolism | 20 | 20 | 20 | 20 | 1.91 | 1.562 | 1.218 | 2.517 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.938859506774495 | 0.972868731003358 | 0.958705855138011 | 0.959522188921769 | 312569.127047718 | 79336.1029165598 | 280190.614862653 | 2.13357824001936E7 | 1.96436562290884E7 | 9081648.29120601 | 1.01259485831113E7 | 9467201.29798786 | 1.55257573035923E7 | 3.31547939620584E7 | 3.43565739025104E7 | 2.75852274417617E7 | 1.43901632993649E7 | 7722776.69094361 | 1.86748082798887E7 |
| P63017 | Heat shock cognate 71 kDa protein [OS=Mus musculus] | 161.557 | 53 | 28 | 572 | 23 | 646 | 70.8 | cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component | signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function | 15481 | ENSMUSG00000015656 | Hspa8 | mmu:15481; P08109; P12225; P63017; Q3U6R0; Q3U764; Q3U7D7; Q3U7E2; Q3U9B4; Q3U9G0; Q3UGM0; Q5FWJ6; Q62373; Q62374; Q62375; Q6NZD0 | Mapk signaling pathway; Exercise-induced circadian regulation | Neutrophil degranulation; mRNA Splicing - Major Pathway; Regulation of HSF1-mediated heat shock response; PKR-mediated signaling; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis; Attenuation phase; Lysosome Vesicle Biogenesis; GABA synthesis, release, reuptake and degradation; AUF1 (hnRNP D0) binds and destabilizes mRNA; Protein methylation | 20 | 20 | 20 | 20 | 1.586 | 1.511 | 0.674 | 3.559 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.987939278265184 | 0.953011140807089 | 0.709593139419252 | 0.587315224195015 | 247063.168316828 | 221267.865667273 | 228333.997143376 | 2.34302361722569E7 | 1.91610816116977E7 | 2.44529780700925E7 | 1.52458610795295E7 | 1.21057626921531E7 | 1.98188188374949E7 | 4.35786305197153E7 | 3.523488629513E7 | 2.44125225303247E7 | 1.30838270231471E7 | 9679200.3009757 | 1.32405397257932E7 |
| Q9JHU4 | Cytoplasmic dynein 1 heavy chain 1 [OS=Mus musculus] | 161.009 | 14 | 55 | 258 | 55 | 4644 | 531.7 | cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes | cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 13424 | ENSMUSG00000018707 | Dync1h1 | E9QM71; mmu:13424; Q9JHU4 | MHC class II antigen presentation; Neutrophil degranulation; Separation of Sister Chromatids; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; COPI-mediated anterograde transport; Recruitment of NuMA to mitotic centrosomes; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-independent Golgi-to-ER retrograde traffic; Aggrephagy; Anchoring of the basal body to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; AURKA Activation by TPX2 | 0.975 | 1.246 | 1.606 | 1.856 | 2.687 | 1.626 | 1.854 | 2.534 | 0.591873375996003 | 0.826895204418257 | 0.758743075163871 | 0.936818656936794 | 0.771389136401717 | 0.987352798667733 | 0.695927216301667 | 0.953305976192702 | 224060.75101347 | 288932.991027563 | 370866.333925136 | 1035717.43113769 | 1898525.78207622 | 892363.147243056 | 298543.620628635 | 395801.785314415 | 659710.172961205 | 5741364.17159479 | 5412980.23144293 | 4332188.15134028 | 1541170.38578568 | 1219184.02821873 | 1626625.47525789 | |
| Q99K41 | EMILIN-1 [OS=Mus musculus] | 157.011 | 31 | 21 | 244 | 21 | 1017 | 107.5 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 100952 | ENSMUSG00000029163 | Emilin1 | mmu:100952; Q99K41 | Molecules associated with elastic fibres | 20 | 20 | 20 | 20 | 0.468 | 2.622 | 0.322 | 3.831 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.169879542413978 | 0.64186124184599 | 0.0921665663508908 | 0.491906845171331 | 6287128.66260445 | 6034831.78772075 | 4173278.84836641 | 1744058.35010072 | 1513530.29654839 | 1757558.94039384 | 2698540.13579468 | 2559754.7470142 | 1836473.80243277 | 371444.218276851 | 286714.652107864 | 495091.120602366 | ||||
| Q61879 | Myosin-10 [OS=Mus musculus] | 146 | 19 | 31 | 236 | 20 | 1976 | 228.9 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;nucleic acid binding activity;other molecular function | 77579 | ENSMUSG00000020900 | Myh10 | mmu:77579; Q5SV63; Q61879 | Regulation of actin cytoskeleton | RHO GTPases activate PAKs | 1.209 | 0.791 | 1.357 | 2.489 | 1.52 | 1.681 | 1.232 | 2.649 | 0.705689538076567 | 0.506231596289679 | 0.676239752697828 | 0.933545599871938 | 0.996007724449986 | 0.990096171400123 | 0.953146340313072 | 0.921444667457376 | 132922.802732814 | 81410.1821075416 | 155803.703539863 | 578601.376274227 | 569525.366217458 | 228469.06472958 | 249877.75631 | 195698.454667987 | 352494.602688902 | 1222751.03080206 | 1020719.46631895 | 1025108.65415173 | 659882.564109888 | 489393.525760184 | 539451.948957579 |
| Cont_P00761 | Trypsin OS=Sus scrofa OX=9823 PE=1 SV=1 | 143.502 | 62 | 11 | 3859 | 10 | 231 | 24.4 | protein metabolism;other biological processes | non-structural extracellular | other molecular function | 0.498 | 0.443 | 0.689 | 0.579 | 0.942 | 1.146 | 1.203 | 1.114 | 0.254996071775817 | 0.172153475402034 | 0.357784551188889 | 0.34040294575649 | 0.822223648478518 | 0.740968241512781 | 0.960577895552113 | 0.148582186670595 | 5.17896971017178E9 | 5.13317471139103E9 | 7.27761160813741E9 | 2.70973552724487E9 | 1.73168232498425E9 | 2.0962236592694E9 | 3.08554430734093E9 | 3.85764460784296E9 | 3.06099934235171E9 | 1.42194297351806E9 | 1.8379662886425E9 | 3.81973460995747E9 | 5.23567407489624E9 | 5.3849654871275E9 | 2.81761370832162E9 | ||||||
| P20029 | Endoplasmic reticulum chaperone BiP [OS=Mus musculus] | 142.966 | 48 | 25 | 434 | 23 | 655 | 72.4 | protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component | enzyme regulator activity;translation activity;other molecular function | 14828 | ENSMUSG00000026864 | Hspa5 | mmu:14828; O35642; P20029; Q3UFF2; Q61630 | Mapk signaling pathway | Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Regulation of HSF1-mediated heat shock response | 20 | 20 | 20 | 20 | 2.034 | 1.181 | 1.138 | 2.043 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.916283277860523 | 0.769590657123576 | 0.985707795620743 | 0.888702680095366 | 7850142.93480902 | 7648809.53150357 | 9169945.31743656 | 7535475.80605118 | 5802650.52918468 | 8839942.11003441 | 1.89485602512479E7 | 1.6006905998567E7 | 1.24118184289709E7 | 8533209.24248049 | 7216046.0503345 | 9459779.49149077 | |||
| Cont_P13647 | Keratin, type II cytoskeletal 5 OS=Homo sapiens OX=9606 GN=KRT5 PE=1 SV=3 | 142.395 | 51 | 34 | 500 | 20 | 590 | 62.3 | cell organization and biogenesis;other biological processes | cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;cytoskeletal activity;other molecular function | 3852 | ENSG00000186081 | KRT5 | hsa:3852; P13647; Q6PI71; Q6UBJ0; Q8TA91 | Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin; Developmental Lineage of Mammary Stem Cells; Developmental Lineage of Mammary Gland Myoepithelial Cells; Type I hemidesmosome assembly | 1.412 | 1.296 | 1.45 | 3.637 | 1.063 | 1.124 | 2.854 | 0.442 | 0.786915923361782 | 0.847457711018997 | 0.707170943024881 | 0.746833150482801 | 0.873755746039336 | 0.714156118974909 | 0.2733017775894 | 2.49132633766938E-5 | 5120503.46953844 | 5171426.92187225 | 6553368.21772984 | 9669299.63907403 | 1.1127930529353E7 | 9127716.50969809 | 9513581.76230213 | 7584977.17814252 | 6506980.60696686 | 1.59683716443188E7 | 1.28154121523541E7 | 1.32126695164861E7 | 5.39600661696836E7 | 1.8678004759752E7 | 1.36191738010446E7 | |
| Cont_P08779 | Keratin, type I cytoskeletal 16 OS=Homo sapiens OX=9606 GN=KRT16 PE=1 SV=4 | 140.751 | 54 | 25 | 569 | 12 | 473 | 51.2 | cell organization and biogenesis;stress response;other biological processes | plasma membrane;cytosol;cytoskeleton | cytoskeletal activity | 3868 | ENSG00000186832 | KRT16 | A8K488; hsa:3868; P08779; P30654; Q16402; Q9UBG8 | Vitamin D receptor pathway | Formation of the cornified envelope | 1.858 | 1.769 | 1.616 | 2.725 | 0.945 | 0.933 | 1.398 | 0.544 | 0.941324060398065 | 0.961351301268194 | 0.761460393544015 | 0.887279041944908 | 0.82543231800733 | 0.493923182294169 | 0.895302208460818 | 3.1065941501805E-4 | 1047544.82178002 | 1389728.97312405 | 1389730.63830375 | 1501449.09449526 | 2307427.01338473 | 2939547.44501319 | 7196685.12946156 | 1715910.61220057 | 2812173.28112121 | 4331979.12309994 | 1639569.64130669 | 1737373.70058763 | 9547147.41410007 | 4434008.92515372 | 2223613.02167429 |
| Cont_P02465 | Collagen alpha-2(I) chain OS=Bos taurus OX=9913 GN=COL1A2 PE=1 SV=2 | 139.99 | 18 | 19 | 445 | 3 | 1364 | 129 | non-structural extracellular;extracellular matrix | extracellular structural activity;other molecular function | 282188 | ENSBTAG00000013472 | COL1A2 | A6QP13; bta:282188; O62649; P02465 | Inflammatory response pathway; Focal adhesion | Fibronectin matrix formation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Collagen degradation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; Collagen chain trimerization; GPVI-mediated activation cascade; Platelet Aggregation (Plug Formation); Platelet Adhesion to exposed collagen; GP1b-IX-V activation signalling | 0.802 | 1.357 | 0.812 | 0.776 | 0.839 | 0.601 | 0.572 | 1.046 | 0.483779141493222 | 0.876027096029978 | 0.421836754550416 | 0.488872343346086 | 0.731850662833984 | 0.076245756040016 | 0.549852418071669 | 0.432748651973214 | 80849.8235508145 | 93725.5578519836 | 35755.9745173747 | 170240.553800628 | 153570.468872413 | 167384.810476394 | 78292.6458688874 | 70345.2867467554 | 108688.239366299 | 65032.7123193958 | 48396.6073357386 | 51482.0177898574 | 32903.9376967684 | 51011.1923790395 | 62191.0072542807 | |
| Cont_P12763 | Alpha-2-HS-glycoprotein OS=Bos taurus OX=9913 GN=AHSG PE=1 SV=2 | 132.772 | 50 | 16 | 1191 | 16 | 359 | 38.4 | stress response;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component | enzyme regulator activity | 280988 | AHSG | A6QLF7; bta:280988; P12763 | Neutrophil degranulation; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 0.943 | 1.184 | 1.213 | 0.612 | 1.313 | 0.781 | 0.463 | 2.11 | 0.573667790345329 | 0.793013134473823 | 0.624272910267193 | 0.36488675645736 | 0.946568086066385 | 0.268930374946741 | 0.335956814949331 | 0.913214993335179 | 6.75081036645858E8 | 9.56771805796805E8 | 4.32862555462728E8 | 6.04790296716478E8 | 6.42824998486085E8 | 6.76887564991134E8 | 8.54466282868744E8 | 8.4303805016043E8 | 9.16216503216691E8 | 7.41908408260606E8 | 7.48114705273509E8 | 6.29285280642112E8 | 3.25834950231514E8 | 3.42283489676807E8 | 6.64083343401506E8 | ||
| P07901 | Heat shock protein HSP 90-alpha [OS=Mus musculus] | 132.382 | 43 | 25 | 402 | 16 | 733 | 84.7 | cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component | signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function | 15519 | ENSMUSG00000021270 | Hsp90aa1 | mmu:15519; P07901 | EBV LMP1 signaling; Focal adhesion: PI3K-Akt-mTOR signaling pathway; IL-6 signaling pathway; IL-2 signaling pathway | Regulation of necroptotic cell death; Recruitment of NuMA to mitotic centrosomes; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of actin dynamics for phagocytic cup formation; Neutrophil degranulation; Downregulation of ERBB2 signaling; Anchoring of the basal body to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; AURKA Activation by TPX2; Extra-nuclear estrogen signaling; Attenuation phase; Estrogen-dependent gene expression; Sema3A PAK dependent Axon repulsion; VEGFR2 mediated vascular permeability; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation; DDX58/IFIH1-mediated induction of interferon-alpha/beta; eNOS activation; HSF1 activation; RHOBTB2 GTPase cycle; Drug-mediated inhibition of ERBB2 signaling | 20 | 0.796 | 20 | 9.684 | 1.447 | 2.287 | 1.041 | 3.222 | 1.65082956259427E-17 | 0.508730894200713 | 1.50457038391225E-17 | 0.251664970734015 | 0.974827674952665 | 0.788764875934969 | 0.968364585136618 | 0.745600589176001 | 51071.3130902855 | 169244.190500369 | 193833.457176882 | 3826029.08230807 | 4600695.96516161 | 3479662.10980986 | 1533159.7098775 | 1700635.66665037 | 1768278.53880507 | 6471421.59388824 | 6122550.53993506 | 5450079.38924241 | 1704183.40484156 | 900341.190737514 | 2215799.13247972 |
| Q02819 | Nucleobindin-1 [OS=Mus musculus] | 131.152 | 51 | 21 | 299 | 21 | 459 | 53.4 | signal transduction | non-structural extracellular;other membranes;ER/Golgi | enzyme regulator activity;nucleic acid binding activity;other molecular function | 18220 | ENSMUSG00000030824 | Nucb1 | mmu:18220; Q02819; Q3TU42; Q9CWA1; Q9D8J4; Q9DBL3 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 20 | 20 | 20 | 14.326 | 0.375 | 3.321 | 0.498 | 2.52 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 0.130903496983571 | 0.0679830640731695 | 0.340647566778883 | 0.397987186613988 | 0.958122559708965 | 41072.7931792495 | 20198.6046706008 | 1.70846710933602E7 | 1.97547416617741E7 | 2.08807433533847E7 | 5757191.6972993 | 4828078.95450858 | 5895038.38978249 | 7136546.74332753 | 7387752.88718417 | 5120327.81590923 | 2637872.59598673 | 1130733.36645935 | 3369667.63744922 | ||
| Q91V92 | ATP-citrate synthase [OS=Mus musculus] | 129.973 | 32 | 28 | 237 | 28 | 1091 | 119.7 | other metabolic processes | cytosol | other molecular function | 104112 | ENSMUSG00000020917 | Acly | mmu:104112; Q91V92 | Fatty acid biosynthesis | Neutrophil degranulation; Fatty acyl-CoA biosynthesis | 9.31 | 4.235 | 7.838 | 5.627 | 0.759 | 1.697 | 0.624 | 2.139 | 0.230775890814232 | 0.371468864113786 | 0.437429424171984 | 0.509570119936397 | 0.626059420687734 | 0.98558531112136 | 0.643183834410259 | 0.922580167429744 | 8856.99380706579 | 32765.2400642807 | 40990.0091117865 | 2382723.31982566 | 2481678.51703659 | 2154876.39410613 | 1256305.5375454 | 885993.369046538 | 1688459.92743218 | 2057502.05407172 | 1815562.79058184 | 1460220.9588277 | 594587.914542531 | 534991.757912276 | 802971.776166877 |
| A2ASQ1 | Agrin [OS=Mus musculus] | 128.989 | 18 | 26 | 227 | 26 | 1950 | 207.4 | cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cell component | signal transduction activity or receptor binding;other molecular function | 11603 | ENSMUSG00000041936 | Agrn | A2ASP9; A2ASQ0; A2ASQ1; B2RWU1 | Primary focal segmental glomerulosclerosis (FSGS) | ECM proteoglycans; Retinoid metabolism and transport; Glycosaminoglycan-protein linkage region biosynthesis; HS-GAG biosynthesis; HS-GAG degradation; Formation of the dystrophin-glycoprotein complex (DGC) | 20 | 20 | 20 | 20 | 0.661 | 1.77 | 0.657 | 1.948 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.460727828548759 | 0.972791368602389 | 0.686318824668434 | 0.846971399004193 | 2612028.52511147 | 3116500.52541199 | 3328171.1398056 | 1818519.74579979 | 1551006.46226864 | 1715477.48863677 | 2313945.16119856 | 2044906.61336417 | 1778324.63596447 | 957812.214242183 | 632566.873707257 | 1496109.18442141 | |||
| Q61508 | Extracellular matrix protein 1 [OS=Mus musculus] | 127.379 | 45 | 18 | 358 | 18 | 559 | 62.8 | stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular | signal transduction activity or receptor binding;other molecular function | 13601 | ENSMUSG00000028108 | Ecm1 | mmu:13601; Q3U5Q5; Q61508 | Platelet degranulation | 20 | 20 | 20 | 14.914 | 0.149 | 1.214 | 0.053 | 3.546 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 0.121600547823456 | 2.27890527565265E-4 | 0.795351011232032 | 1.51989274634622E-7 | 0.592370654746194 | 110159.96586707 | 68619.5270607555 | 45654.6843175291 | 5.6443097497098E7 | 7.11751205740166E7 | 5.82782830048746E7 | 5.1935854689884E7 | 4.50204039942893E7 | 5.70225374161979E7 | 1.27540105597053E7 | 1.25514774649527E7 | 8690203.83604475 | 3690111.31703252 | 2192350.97546663 | 4663417.73981907 | |
| Cont_P04259 | Keratin, type II cytoskeletal 6B OS=Homo sapiens OX=9606 GN=KRT6B PE=1 SV=5 | 126.901 | 47 | 30 | 442 | 4 | 564 | 60 | cell organization and biogenesis;other biological processes | cytosol;cytoskeleton | bone, tooth or skin structural activity;cytoskeletal activity | 3854 | ENSG00000185479 | KRT6B | hsa:3854; P04259; P48669 | Formation of the cornified envelope | 1.588 | 2.045 | 1.606 | 3.292 | 1.017 | 0.828 | 1.287 | 0.641 | 0.857251372850113 | 0.868132360832926 | 0.758743075163871 | 0.801271130817871 | 0.854305439376382 | 0.340133476321195 | 0.937453377971347 | 0.00123883404563536 | 267279.779286483 | 355493.362381868 | 274137.281616349 | 326989.588402741 | 585438.697100962 | 617622.938974811 | 2390973.53573307 | 430931.486741926 | 646270.614315847 | 1869779.42318807 | 346417.77494154 | 348508.009299423 | 1653754.7898307 | 1155463.67620058 | 538093.594898596 | |
| P17182 | Alpha-enolase [OS=Mus musculus] | 126.804 | 60 | 19 | 244 | 16 | 434 | 47.1 | other metabolic processes;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;other cell component | nucleic acid binding activity;other molecular function | 13806; 433182 | ENSMUSG00000059040; ENSMUSG00000063524 | Eno1 | mmu:13806; mmu:433182; P17182; Q99KT7; Q9DCY7 | Glycolysis and gluconeogenesis | 20 | 20 | 20 | 20 | 2.837 | 1.204 | 1.518 | 2.329 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.720832939248489 | 0.789540446904924 | 0.858218537342417 | 0.989544231571828 | 31098.019126098 | 70318.9502605952 | 40658.6319347469 | 1.28655809626545E7 | 1.34726279447959E7 | 7101469.5445256 | 9089751.86845938 | 7552189.93174957 | 1.17772011823713E7 | 3.50544676757808E7 | 2.99447661492486E7 | 2.18255690502528E7 | 1.30151947674988E7 | 1.11532480577619E7 | 1.75489228796712E7 | |
| P08113 | Endoplasmin [OS=Mus musculus] | 126.346 | 39 | 26 | 329 | 25 | 802 | 92.4 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cell component | signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function | 22027 | ENSMUSG00000020048 | Hsp90b1 | mmu:22027; P08113; P11427 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Hypoxia-dependent self-renewal of myoblasts | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Scavenging by Class A Receptors; Trafficking and processing of endosomal TLR; Interleukin-4 and Interleukin-13 signaling | 14.282 | 15.982 | 20 | 11.019 | 2.346 | 1.275 | 1.501 | 2.064 | 0.107476768049312 | 0.0104456807471941 | 1.50457038391225E-17 | 0.205304099107124 | 0.854305439376382 | 0.840785133352029 | 0.866766165039268 | 0.896996950298791 | 75656.6139115948 | 52183.5314261123 | 29905.9702816436 | 5932785.14172209 | 5786569.94317903 | 3299962.37110113 | 3817668.17887426 | 3366255.7650389 | 4907428.60350699 | 1.47606948013545E7 | 1.21020755462977E7 | 1.0441016038914E7 | 6464144.86133097 | 3792376.91369813 | 7854793.82920015 |
| P58252 | Elongation factor 2 [OS=Mus musculus] | 126.048 | 37 | 31 | 378 | 30 | 858 | 95.3 | cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;translational apparatus;other cell component | cytoskeletal activity;translation activity;nucleic acid binding activity;other molecular function | 13629 | ENSMUSG00000034994 | Eef2 | mmu:13629; P58252; Q544E4 | Translation factors | Neutrophil degranulation; Protein methylation; Peptide chain elongation; Synthesis of diphthamide-EEF2 | 7.873 | 5.944 | 7.322 | 3.019 | 1.183 | 1.75 | 0.816 | 2.548 | 0.299809054080284 | 0.188334321166369 | 0.471929633209224 | 0.84258396038376 | 0.922179983282929 | 0.97504218639442 | 0.866546043492515 | 0.950878070645738 | 275529.241689771 | 247076.7728808 | 166294.142173825 | 1.22498155967913E7 | 1.26488626480754E7 | 6800245.14611723 | 5717562.35282925 | 5172569.64432748 | 8352282.82529915 | 1.55667000517401E7 | 1.33925688878402E7 | 1.02378508629272E7 | 5184391.52691505 | 2972661.18095993 | 6421886.97759523 |
| Cont_P02538 | Keratin, type II cytoskeletal 6A OS=Homo sapiens OX=9606 GN=KRT6A PE=1 SV=3 | 123.757 | 47 | 30 | 454 | 3 | 564 | 60 | cell organization and biogenesis;stress response;other biological processes | cytosol;cytoskeleton | bone, tooth or skin structural activity;cytoskeletal activity | 3853 | ENSG00000205420 | KRT6A | A4QPC1; hsa:3853; P02538; P48667; Q08AR4; Q6NT67; Q96CL4 | Ectoderm differentiation; Ectoderm differentiation; Pancreatic cancer subtypes | Formation of the cornified envelope | 1.699 | 1.759 | 1.562 | 3.017 | 0.903 | 0.993 | 1.821 | 0.574 | 0.892533464536408 | 0.964633336683333 | 0.745886066139481 | 0.84258396038376 | 0.792564971776066 | 0.574739141583974 | 0.709593139419252 | 5.66461038960431E-4 | 2017098.82314832 | 2171650.09464557 | 2359880.73116726 | 2825309.68904382 | 4320098.03084773 | 4192074.59940388 | 8075888.41129776 | 2685265.07688442 | 3594101.84504227 | 5878699.8667026 | 3215829.01184206 | 2854010.96069105 | 1.30998597349634E7 | 8158147.16608847 | 4198498.19802621 |
| P97298 | Pigment epithelium-derived factor [OS=Mus musculus] | 123.502 | 47 | 16 | 346 | 12 | 417 | 46.2 | cell cycle OR cell proliferation;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | enzyme regulator activity | 20317 | ENSMUSG00000000753 | Serpinf1 | mmu:20317; O70629; O88691; P97298 | 20 | 5.45 | 7.9 | 3.48 | 0.255 | 3.903 | 0.445 | 2.758 | 1.65082956259427E-17 | 0.227296093012204 | 0.434748506750565 | 0.770205086382264 | 0.00901230529014985 | 0.174886032348437 | 0.300753028734261 | 0.891044455497809 | 554016.1710638 | 470705.490372182 | 363015.858993357 | 5.24905837082578E7 | 7.20656975211191E7 | 8.90978835263609E7 | 1.55195541438312E7 | 1.33807646088142E7 | 1.504676823338E7 | 1.63245792137601E7 | 1.5700230598517E7 | 1.5246806329463E7 | 4897006.93274029 | 3869051.7420588 | 8996988.40278734 | ||
| Q70E20 | Sushi, nidogen and EGF-like domain-containing protein 1 [OS=Mus musculus] | 122.942 | 19 | 22 | 287 | 22 | 1403 | 151.5 | cell adhesion | non-structural extracellular;extracellular matrix | other molecular function | 208777 | Sned1 | A6H6I3; mmu:208777; Q70E20; Q810H2; Q8BMD9 | 20 | 20 | 20 | 20 | 2.169 | 2.063 | 1.623 | 2.787 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.889058672589993 | 0.869908412860824 | 0.817293288705596 | 0.880760468933162 | 62940.5062355012 | 25184.2741656831 | 25459.8187779288 | 7879183.70581794 | 8304827.25748066 | 2617617.70526214 | 3110990.0320528 | 3263544.92621848 | 3507274.08693078 | 1.72480350493842E7 | 1.48489121993504E7 | 1.05732378776404E7 | 5373074.41423662 | 2537287.1447922 | 7075122.99473268 | |||
| P13020 | Gelsolin [OS=Mus musculus] | 122.934 | 35 | 22 | 377 | 9 | 780 | 85.9 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 227753 | ENSMUSG00000026879 | Gsn | mmu:227753; P13020; Q3UPB1; Q8R590 | Regulation of actin cytoskeleton | Neutrophil degranulation; Caspase-mediated cleavage of cytoskeletal proteins | 5.883 | 4.057 | 14.912 | 7.221 | 3.038 | 1.646 | 1.821 | 3.103 | 0.440427841758307 | 0.396306424610341 | 0.186266168629733 | 0.379422692457324 | 0.65414435708462 | 0.994546642862744 | 0.709593139419252 | 0.793590033024783 | 1154075.61374729 | 1486973.5078743 | 778278.604931373 | 1.0611315000974E7 | 9755419.92114226 | 9110194.21443976 | 6039243.17546894 | 5549542.61366164 | 7725308.54354706 | 3.63344365935893E7 | 2.77403609084757E7 | 2.33574049877416E7 | 1.03453705657478E7 | 8417203.0170929 | 1.43392014575414E7 |
| Q61398 | Procollagen C-endopeptidase enhancer 1 [OS=Mus musculus] | 120.4 | 40 | 14 | 323 | 14 | 468 | 50.1 | protein metabolism;other biological processes | enzyme regulator activity;other molecular function | 18542 | ENSMUSG00000029718 | Pcolce | mmu:18542; O35113; Q61398 | mRNA processing | Collagen biosynthesis and modifying enzymes; Crosslinking of collagen fibrils | 20 | 20 | 16.934 | 8.868 | 0.439 | 1.204 | 0.32 | 1.719 | 1.65082956259427E-17 | 1.8644578313253E-17 | 0.151224536345852 | 0.288320039261486 | 0.133905327763598 | 0.789540446904924 | 0.0895861566882082 | 0.711902858921665 | 55825.2363051742 | 84655.3590880939 | 113029.200120433 | 3.10244208090572E7 | 2.97623271730106E7 | 2.79757713270171E7 | 2.72578314339105E7 | 2.28908828526637E7 | 2.54654481194513E7 | 1.54882233602667E7 | 1.24902767859117E7 | 9636426.2851997 | 7984547.74798259 | 5125325.32901055 | 9907837.52014591 | |
| P26039 | Talin-1 [OS=Mus musculus] | 118.226 | 15 | 30 | 153 | 30 | 2541 | 269.7 | cell adhesion;cell organization and biogenesis;signal transduction | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;other molecular function | 21894 | ENSMUSG00000028465 | Tln1 | A2AIM8; mmu:21894; P26039; Q8VEF0 | Primary focal segmental glomerulosclerosis (FSGS); Integrin-mediated cell adhesion; Focal adhesion | Platelet degranulation ; MAP2K and MAPK activation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; Smooth Muscle Contraction; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 2.278 | 1.64 | 4.713 | 1.234 | 2.379 | 2.301 | 1.474 | 3.671 | 0.958262397335385 | 0.994542145304377 | 0.680632778351053 | 0.738983404380581 | 0.850917681937748 | 0.783910800136359 | 0.87222702623065 | 0.535066779633529 | 137218.697336797 | 64798.4580467583 | 241653.653741064 | 580168.664793601 | 803244.58151111 | 320387.746187394 | 118081.406885094 | 124079.798936285 | 255551.526824265 | 2877993.84785898 | 2114900.66089323 | 1881659.61273992 | 234819.255172709 | 240671.449108311 | 385063.079961369 |
| Q8BPB5 | EGF-containing fibulin-like extracellular matrix protein 1 [OS=Mus musculus] | 117.738 | 49 | 15 | 220 | 15 | 493 | 54.9 | protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes | extracellular matrix | signal transduction activity or receptor binding;kinase activity;other molecular function | 216616 | ENSMUSG00000020467 | Efemp1 | mmu:216616; Q6Y3N6; Q8BPB5 | 20 | 20 | 20 | 7.265 | 0.542 | 1.608 | 0.36 | 2.306 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 0.376780684027729 | 0.278244203695445 | 0.983440558239231 | 0.145805028390539 | 0.982581944728745 | 15298.8221438323 | 19141.8575027524 | 55545.7753728227 | 7090020.68988726 | 8805500.10345141 | 5126350.07183034 | 4435222.67421531 | 4392813.74676133 | 4496081.41897935 | 4016966.57007158 | 3984703.05528875 | 2817881.79753384 | 1462163.85427198 | 682456.349264741 | 1966499.77195883 | ||
| P09411 | Phosphoglycerate kinase 1 [OS=Mus musculus] | 116.462 | 57 | 18 | 287 | 18 | 417 | 44.5 | protein metabolism;other metabolic processes;stress response;other biological processes | non-structural extracellular;other membranes;cytosol;mitochondrion;other cell component | kinase activity;other molecular function | 18655 | ENSMUSG00000062070 | Pgk1 | mmu:18655; P09411; Q3TPE6; Q3UKV8; Q5XJE7 | Glycolysis and gluconeogenesis | Gluconeogenesis; Glycolysis | 20 | 20 | 20 | 20 | 3.557 | 1.177 | 1.619 | 2.753 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.465126095372736 | 0.766862952867809 | 0.820281310709571 | 0.891044455497809 | 78089.4641074341 | 38741.0917691314 | 23421.0514741904 | 4316274.39280249 | 5023293.68471847 | 1442874.888393 | 2829873.33459098 | 2934698.045784 | 3868274.47312523 | 1.65254946701665E7 | 1.56270051770472E7 | 1.22346365889796E7 | 4530199.20599689 | 2315853.03926933 | 6654180.61411261 |
| P27773 | Protein disulfide-isomerase A3 [OS=Mus musculus] | 115.891 | 55 | 23 | 291 | 23 | 505 | 56.6 | cell adhesion;cell organization and biogenesis;stress response;signal transduction;other biological processes | non-structural extracellular;other membranes;ER/Golgi;other cell component | nucleic acid binding activity;other molecular function | 14827 | ENSMUSG00000027248 | Pdia3 | mmu:14827; P27773; Q3TEI9; Q3TIL2; Q3UZK8; Q8C2F4; Q99LF6 | ER-Phagosome pathway; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Calnexin/calreticulin cycle | 2.463 | 2.512 | 6.915 | 2.818 | 2.389 | 1.306 | 1.442 | 2.187 | 0.9135584231482 | 0.736536116100563 | 0.498293621965442 | 0.874168055361729 | 0.850917681937748 | 0.862063111456553 | 0.881496352314601 | 0.939046770372612 | 206281.038958907 | 253939.7116523 | 128510.108086966 | 6669793.66068216 | 7133803.24141356 | 5637352.69437344 | 5319375.96186612 | 3844376.07822282 | 6321729.00885173 | 1.83298906806341E7 | 1.50101054148645E7 | 1.26051366299531E7 | 6670485.36185494 | 6059857.55300524 | 8984695.03809976 | |
| P10107 | Annexin A1 [OS=Mus musculus] | 115.566 | 64 | 18 | 270 | 18 | 346 | 38.7 | cell organization and biogenesis;stress response;transport;signal transduction;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component | enzyme regulator activity;other molecular function | 16952 | ENSMUSG00000024659 | Anxa1 | mmu:16952; P10107 | Spinal cord injury; Prostaglandin synthesis and regulation | G alpha (q) signalling events; G alpha (i) signalling events; Formyl peptide receptors bind formyl peptides and many other ligands | 20 | 7.59 | 20 | 20 | 1.749 | 3.163 | 2.185 | 2.632 | 1.65082956259427E-17 | 0.105053536950499 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.954328834404239 | 0.401885831342676 | 0.529099828181544 | 0.924766494197286 | 13280.9290610842 | 9160.53166722029 | 4508.77124840677 | 5251880.61554565 | 6740833.31198439 | 6058745.6526555 | 1560362.01883491 | 1521121.84391776 | 1946127.08618424 | 1.11990207127477E7 | 1.0990927807692E7 | 1.0321301103113E7 | 4605609.45936174 | 3223846.7434476 | 4805492.80063037 |
| Cont_Q2KJF1 | Alpha-1B-glycoprotein OS=Bos taurus OX=9913 GN=A1BG PE=1 SV=1 | 115.502 | 48 | 14 | 224 | 14 | 503 | 53.5 | signal transduction | non-structural extracellular;plasma membrane;other membranes | 518955 | A1BG | bta:518955; Q2KJF1 | Platelet degranulation ; Neutrophil degranulation | 1.057 | 0.967 | 1.256 | 0.607 | 1.203 | 1.109 | 0.599 | 2.051 | 0.635218461842139 | 0.655487072215252 | 0.641514600397631 | 0.360991986803736 | 0.932231143665149 | 0.696358249006924 | 0.601376052147163 | 0.891044455497809 | 1.12339445909494E7 | 1.09217008752481E7 | 5999938.28834399 | 7597724.26810103 | 8696294.29830821 | 1.02832125493257E7 | 1.08372253099689E7 | 9914324.88654618 | 8710997.51604168 | 1.11963323092602E7 | 9450705.94975847 | 1.03053408353504E7 | 5283853.74244175 | 5535891.07899516 | 9467766.08082133 | |||
| Cont_Q3MHN5 | Vitamin D-binding protein OS=Bos taurus OX=9913 GN=GC PE=2 SV=1 | 113.599 | 55 | 20 | 319 | 20 | 474 | 53.3 | other metabolic processes;transport | non-structural extracellular;other cell component | transporter activity;cytoskeletal activity;other molecular function | 530076 | GC | bta:530076; Q3MHN5 | 0.903 | 1.209 | 1.108 | 0.763 | 1.298 | 0.671 | 0.583 | 1.405 | 0.549057967251154 | 0.804331105646976 | 0.579435037816218 | 0.479472599858427 | 0.946173787415917 | 0.139718417146003 | 0.570795727084329 | 0.421365656927814 | 1.55879441314789E7 | 1.53074066841615E7 | 7458694.29508707 | 1.04365108192777E7 | 1.20620475306269E7 | 8309099.82300618 | 1.67215053413279E7 | 1.54231806136738E7 | 1.57780518794517E7 | 1.6556516146824E7 | 1.52311500265876E7 | 1.20681229464E7 | 8133055.93664235 | 9478628.98672491 | 1.47438110125204E7 | |||
| P17742 | Peptidyl-prolyl cis-trans isomerase A [OS=Mus musculus] | 113.527 | 60 | 9 | 369 | 9 | 164 | 18 | cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes | non-structural extracellular;cytosol;nucleus;other cell component | signal transduction activity or receptor binding;other molecular function | 268373 | ENSMUSG00000071866 | Ppia | mmu:268373; P17742; Q9CWJ5; Q9R137 | Neutrophil degranulation; Basigin interactions | 14.843 | 7.75 | 20 | 20 | 1.304 | 2.489 | 0.969 | 4.305 | 0.100219677394751 | 0.099382125133403 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.946239447314336 | 0.696358249006924 | 0.937453377971347 | 0.331144967260478 | 1.16891341386391E7 | 754837.409863468 | 4157779.88062054 | 2.9189343463191E7 | 2.94929696895869E7 | 4.96473559496876E7 | 1.04342545713823E7 | 8178713.43858634 | 1.18234267071803E7 | 4.91534751033825E7 | 4.2865019365108E7 | 4.61937263356195E7 | 9682919.1999608 | 7275434.18699702 | 1.51319991253865E7 | |
| Q69ZN7 | Myoferlin [OS=Mus musculus] | 112.647 | 22 | 36 | 227 | 36 | 2048 | 233.2 | cell organization and biogenesis;other metabolic processes;stress response;other biological processes | plasma membrane;other membranes;nucleus | other molecular function | 226101 | ENSMUSG00000048612 | Myof | mmu:226101; Q69ZN7; Q7TMG0; Q80V33; Q8BU64; Q8BU70; Q8BUC1; Q8BVY6; Q8C0D1; Q8R3B4 | 1.293 | 1.754 | 2.079 | 1.82 | 2.532 | 2.029 | 2.027 | 2.284 | 0.73657372909066 | 0.964709887217926 | 0.888974672311279 | 0.930955411749965 | 0.816275429153737 | 0.877818946381645 | 0.609903091678244 | 0.975029032316037 | 86000.3771233404 | 87234.2597428081 | 50456.7230101595 | 780930.944201502 | 985609.680593147 | 968573.73043394 | 296294.389327177 | 289800.794039455 | 380995.072506467 | 3324626.35891918 | 3238695.05806667 | 2634093.62813707 | 1025817.2029614 | 993761.586050851 | 1295229.11918404 | ||
| P26041 | Moesin [OS=Mus musculus] | 112.068 | 47 | 28 | 353 | 19 | 577 | 67.7 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function | 17698 | ENSMUSG00000031207 | Msn | B1AX70; mmu:17698; P26041; Q3UL28; Q8BSN4 | Regulation of actin cytoskeleton | Recycling pathway of L1 | 20 | 9.275 | 20 | 12.906 | 1.135 | 2.551 | 1.147 | 2.527 | 1.65082956259427E-17 | 0.0604972675946614 | 1.50457038391225E-17 | 0.157138696252226 | 0.910750689050232 | 0.682171843898269 | 0.97925982662951 | 0.954396180425051 | 3509434.20481405 | 4360753.56845675 | 2823311.97478394 | 1.57847182977139E7 | 1.58696599538661E7 | 1.95033967654703E7 | 8383545.44173348 | 7552431.53754312 | 1.1473115873696E7 | 2.43209045148915E7 | 1.7265255344344E7 | 1.55060800034236E7 | 7954804.76477835 | 1.24969658442338E7 | 1.31486313258361E7 |
| P05064 | Fructose-bisphosphate aldolase A [OS=Mus musculus] | 112.015 | 66 | 18 | 261 | 18 | 364 | 39.3 | cell organization and biogenesis;other metabolic processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | other molecular function | 11674 | ENSMUSG00000030695 | Aldoa | mmu:11674; P05064 | Glycolysis and gluconeogenesis | Platelet degranulation ; Neutrophil degranulation; Gluconeogenesis; Glycolysis | 14.735 | 18.407 | 20 | 18.77 | 2.091 | 1.259 | 1.091 | 2.228 | 0.101571037453114 | 0.00616383846364181 | 1.50457038391225E-17 | 0.0771819601934254 | 0.907383519445145 | 0.828577692034317 | 0.988377544628277 | 0.953305976192702 | 36553.7681309936 | 18014.3910425567 | 11156.0078725057 | 5538849.24179232 | 5285372.3367409 | 3856062.26656154 | 4263443.39983126 | 3386915.16711964 | 5306808.16889341 | 1.24814165546298E7 | 1.09515793948855E7 | 8528808.13475854 | 4192052.54158905 | 4075248.71161469 | 5289067.55868911 |
| B2RQC6 | Multifunctional protein CAD [OS=Mus musculus] | 111.853 | 18 | 32 | 111 | 32 | 2225 | 243.1 | other metabolic processes;stress response;transport;developmental processes;other biological processes | cytosol;nucleus;other cell component | kinase activity;other molecular function | 69719 | ENSMUSG00000013629 | Cad | B2RQC6; B7ZN27; mmu:69719 | Mechanisms associated with pluripotency | Pyrimidine biosynthesis | 3.69 | 2.77 | 4.876 | 2.316 | 0.581 | 1.776 | 0.743 | 1.7 | 0.69394578118832 | 0.6681512188534 | 0.666244110962191 | 0.963127218853016 | 0.340675523776301 | 0.968897093792999 | 0.798180783050573 | 0.621633895543644 | 55886.6384121637 | 12993.9975368397 | 34438.2113153553 | 1026045.60319635 | 1025412.85494839 | 821784.178770446 | 383358.762218724 | 322831.339780162 | 640190.890369534 | 516093.312619156 | 478923.162373783 | 363366.537093714 | 127462.003140709 | 110686.677299138 | 180829.981634378 |
| Q8BND5 | Sulfhydryl oxidase 1 [OS=Mus musculus] | 111.186 | 35 | 22 | 242 | 22 | 748 | 82.7 | cell organization and biogenesis;other biological processes | non-structural extracellular;other membranes;ER/Golgi | other molecular function | 104009 | ENSMUSG00000033684 | Qsox1 | mmu:104009; Q3TDY9; Q3TE19; Q3TR29; Q3UEL4; Q8BND5; Q8K041; Q9DBL6 | Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Neutrophil degranulation | 20 | 20 | 20 | 12.613 | 0.491 | 2.489 | 0.46 | 2.797 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 0.162753188077458 | 0.203109767081086 | 0.696358249006924 | 0.331332346840573 | 0.877612009404373 | 40119.4404166161 | 10016.9610840251 | 9134645.28263017 | 1.19624109837519E7 | 1.04856878607794E7 | 3750508.26959308 | 3765475.87858746 | 4032369.19900008 | 5503994.64256118 | 5774708.06447186 | 3841814.38132964 | 1498357.95430882 | 1169677.75963505 | 2786812.01379908 |
A
B
C
D
E
F
G
H
I
J
K
L
M
N
O
P
Q
R
S
T
U
V
W
X
Y
Z
AA
AB
AC
AD
AE
AF
AG
AH
AI
AJ
AK
AL
AM
AN
AO
AP
AQ
AR
AS
AT
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
| Accession | Description | Sum PEP Score | Coverage [%] | # Peptides | # PSMs | # Unique Peptides | # AAs | MW [kDa] | Biological Process | Cellular Component | Molecular Function | Entrez Gene ID | Ensembl Gene ID | Gene Symbol | Gene ID | WikiPathways | Reactome Pathways | Abundance Ratio Adj. P-Value: (LQ_16h) / FM | Abundance Ratio Adj. P-Value: (LQ_6h) / FM | Abundance Ratio Adj. P-Value: (SQ_16h) / FM | Abundance Ratio Adj. P-Value: (SQ_6h) / FM | Abundance Ratio Adj. P-Value: (SQ_16h) / (LQ_16h) | Abundance Ratio Adj. P-Value: (LQ_16h) / (LQ_6h) | Abundance Ratio Adj. P-Value: (SQ_6h) / (LQ_6h) | Abundance Ratio Adj. P-Value: (SQ_16h) / (SQ_6h) | Abundances (Normalized): F1: Sample, FM | Abundances (Normalized): F2: Sample, FM | Abundances (Normalized): F3: Sample, FM | FM_AVERAGE | Abundances (Normalized): F8: Sample, LQ_16h | Abundances (Normalized): F9: Sample, LQ_16h | Abundances (Normalized): F10: Sample, LQ_16h | LQ16h_AVERAGE | Abundances (Normalized): F4: Sample, LQ_6h | Abundances (Normalized): F5: Sample, LQ_6h | Abundances (Normalized): F6: Sample, LQ_6h | LQ6h_AVERAGE | Abundances (Normalized): F17: Sample, SQ_16h | Abundances (Normalized): F18: Sample, SQ_16h | Abundances (Normalized): F20: Sample, SQ_16h | SQ16h_AVERAGE | Abundances (Normalized): F15: Sample, SQ_6h | Abundances (Normalized): F16: Sample, SQ_6h | Abundances (Normalized): F14: Sample, SQ_6h | SQ6h_AVERAGE |
| P11276 | Fibronectin [OS=Mus musculus] | 867.353 | 58 | 95 | 2246 | 59 | 2477 | 272.4 | cell adhesion;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi | signal transduction activity or receptor binding;enzyme regulator activity;other molecular function | 14268 | ENSMUSG00000026193 | Fn1 | G5E8B8; mmu:14268; P11276; Q61567; Q61568; Q61569; Q64233; Q80UI4 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Inflammatory response pathway; Regulation of actin cytoskeleton; Comprehensive IL-17A signaling; Focal adhesion | ECM proteoglycans; Platelet degranulation ; Cell surface interactions at the vascular wall; Syndecan interactions; MAP2K and MAPK activation; Integrin cell surface interactions; Molecules associated with elastic fibres; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Fibronectin matrix formation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; Degradation of the extracellular matrix; Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells; MET activates PTK2 signaling; GPER1 signaling | 0.0844744457809114 | 0.00584906503121538 | 1.50457038391225E-17 | 0.156115961659409 | 0.974036928885484 | 0.564710097967506 | 0.435823028559966 | 0.896613838854506 | 3.10111960161575E7 | 2.79853612635427E7 | 2.39278028537136E7 | 2.7641453377804603E7 | 2.27076161669542E8 | 2.29530848002383E8 | 1.81481696567249E8 | 2.12696235413058E8 | 2.13523563015262E8 | 1.92386583493888E8 | 2.00792310651879E8 | 2.022341523870097E8 | 3.0604731494329E8 | 2.72875123758133E8 | 2.45952285820886E8 | 2.7495824150743634E8 | 1.00071254189999E8 | 1.59531432686856E8 | 1.1928889459527E8 | 1.2629719382404166E8 |
| P11087 | Collagen alpha-1(I) chain [OS=Mus musculus] | 797.017 | 79 | 75 | 1933 | 35 | 1453 | 137.9 | cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12842 | ENSMUSG00000001506 | Col1a1 | mmu:12842; P11087; Q53WT0; Q60635; Q61367; Q61427; Q63919; Q6PCL3; Q810J9 | Osteoblast signaling; Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Comprehensive IL-17A signaling; Focal adhesion | Cell surface interactions at the vascular wall; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ECM proteoglycans; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; GPVI-mediated activation cascade; GP1b-IX-V activation signalling; Platelet Adhesion to exposed collagen; Platelet Aggregation (Plug Formation); MET activates PTK2 signaling | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 1.58880673198775E-4 | 0.381922652011049 | 0.0629214061377862 | 0.655833157547641 | 703080.609341466 | 1047026.5902454 | 567207.050774397 | 772438.0834537543 | 6.12803341835757E8 | 6.28616080368892E8 | 5.37143706349406E8 | 5.92854376184685E8 | 2.20652487774689E8 | 1.86114398805651E8 | 2.17194307013081E8 | 2.0798706453114033E8 | 9.46570689754052E7 | 9.72166914362706E7 | 6.09758172025116E7 | 8.428319253806247E7 | 4.84358218594371E7 | 7.06441702532683E7 | 6.01286898886734E7 | 5.973622733379293E7 |
| Q01149 | Collagen alpha-2(I) chain [OS=Mus musculus] | 773.662 | 80 | 66 | 1731 | 51 | 1372 | 129.5 | cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12843 | ENSMUSG00000029661 | Col1a2 | mmu:12843; Q01149; Q8CGA5 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Focal adhesion | Crosslinking of collagen fibrils; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; ECM proteoglycans; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; GPVI-mediated activation cascade; GP1b-IX-V activation signalling; Platelet Adhesion to exposed collagen; Platelet Aggregation (Plug Formation); MET activates PTK2 signaling | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.0150838661305169 | 0.862063111456553 | 0.0347692006632991 | 0.926292871155025 | 217896.573253055 | 102775.453905646 | 225868.955510701 | 182180.3275564673 | 3.82374533805921E8 | 3.80614155239716E8 | 2.79801552870279E8 | 3.475967473053053E8 | 1.73556920519588E8 | 1.55763113653521E8 | 1.89931753802048E8 | 1.7308392932505235E8 | 1.03217412397752E8 | 1.04517075360638E8 | 6.33578194684048E7 | 9.036410240893161E7 | 2.65479311979207E7 | 5.19818116295111E7 | 4.96147162399626E7 | 4.271481968913147E7 |
| P08121 | Collagen alpha-1(III) chain [OS=Mus musculus] | 695.631 | 63 | 61 | 1789 | 51 | 1464 | 138.9 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | extracellular matrix;other cell component | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 12825 | ENSMUSG00000026043 | Col3a1 | mmu:12825; P08121; Q61429; Q9CRN7 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Focal adhesion | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ECM proteoglycans; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; MET activates PTK2 signaling | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.00738207855214502 | 0.0413994480640273 | 0.394949139624895 | 0.976852696203657 | 619884.023482232 | 468692.52789102 | 275667.802679115 | 454748.1180174556 | 2.79020579584843E8 | 2.94236692581693E8 | 2.78582579285209E8 | 2.8394661715058166E8 | 6.51340156000414E7 | 5.70632610319163E7 | 6.62894421161806E7 | 6.282890624937943E7 | 7.54516142044654E7 | 7.68700494785543E7 | 4.61499837269909E7 | 6.6157215803336866E7 | 2.39448217703501E7 | 3.64849658219652E7 | 3.06665885804687E7 | 3.0365458724261332E7 |
| Q9QXS1 | Plectin [OS=Mus musculus] | 659.702 | 46 | 182 | 1705 | 180 | 4691 | 533.9 | cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component | cytoskeletal activity;other molecular function | 18810 | ENSMUSG00000022565 | Plec | E9QN87; mmu:18810; Q6S384; Q6S389; Q6S394; Q9CS65; Q9QUT2; Q9QXQ8; Q9QXQ9; Q9QXR0; Q9QXR1; Q9QXR2; Q9QXR3; Q9QXR4; Q9QXR5; Q9QXR6; Q9QXR7; Q9QXR8; Q9QXR9; Q9QXS0; Q9QXS1; Q9QXS2; Q9QXS3 | Alpha 6 beta 4 integrin signaling pathway; EGFR1 signaling pathway | Type I hemidesmosome assembly; Caspase-mediated cleavage of cytoskeletal proteins | 0.481729871164266 | 0.714932595871944 | 0.336550483871782 | 0.572524806937582 | 0.850917681937748 | 0.532399788858771 | 0.702330308974487 | 0.520376293994664 | 307407.817065559 | 282192.990008148 | 340166.735457239 | 309922.514176982 | 1.95783440606639E7 | 1.89230076526173E7 | 1.15266683074569E7 | 1.6676006673579365E7 | 3962115.44279651 | 3474477.32513512 | 6361226.57462356 | 4599273.114185064 | 5.1842207663806E7 | 4.48709077668655E7 | 3.18339270889303E7 | 4.28490141732006E7 | 7604177.6415354 | 1.18325057871337E7 | 1.10137014373925E7 | 1.01501282886872E7 |
| P08122 | Collagen alpha-2(IV) chain [OS=Mus musculus] | 526.992 | 64 | 69 | 1077 | 69 | 1707 | 167.2 | RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix | extracellular structural activity | 12827 | ENSMUSG00000031503 | Col4a2 | mmu:12827; P08122; Q3B7C2; Q3TPV9; Q61375; Q66JS5; Q6RCT6; Q6RCT7; Q6U9X1; Q8BPI9; Q8BPK3; Q91VI3 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Focal adhesion | Laminin interactions; Signaling by PDGF; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions | 0.352816378116182 | 0.64759425713406 | 0.293387877727491 | 0.79866917976589 | 0.979628232635575 | 0.169673447599406 | 0.959159975702413 | 0.483015668880262 | 1499335.01530309 | 1691518.00623855 | 989751.415380184 | 1393534.8123072747 | 5.53234274481973E7 | 5.88619201086468E7 | 3.63990683013196E7 | 5.0194805286054574E7 | 1.35123643610626E7 | 1.30555597235297E7 | 1.53773176128868E7 | 1.3981747232493034E7 | 6.80333035906639E7 | 6.55922447276284E7 | 4.55601360762201E7 | 5.972856146483746E7 | 9511844.25395737 | 2.43703078917008E7 | 1.71661195678148E7 | 1.701609057115766E7 |
| Q3U962 | Collagen alpha-2(V) chain [OS=Mus musculus] | 518.514 | 64 | 57 | 817 | 55 | 1497 | 144.9 | cell organization and biogenesis;developmental processes;other biological processes | extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12832 | ENSMUSG00000026042 | Col5a2 | mmu:12832; Q3TVR2; Q3U962; Q3UHK7; Q3UTT4; Q3V1J6; Q61431; Q7TMS0; Q80VS8 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions | 0.861384746267066 | 0.961254912149485 | 0.730324052254867 | 0.632833892117728 | 0.0769666553885184 | 0.273444295895674 | 0.453486790198347 | 0.973358018692255 | 1.96082795853326E7 | 1.89754303457921E7 | 3.46758133166589E7 | 2.4419841082594533E7 | 4.80275081428664E7 | 4.79991185130461E7 | 4.1747532446715E7 | 4.592471970087584E7 | 1.59204573672189E7 | 1.42782577106181E7 | 1.7061559679881E7 | 1.5753424919239333E7 | 2.09575588581227E7 | 1.96948053072084E7 | 2.25862916575107E7 | 2.1079551940947264E7 | 4881772.8383399 | 8018525.34642114 | 1.85137908486988E7 | 1.0471363011153279E7 |
| Q05793 | Basement membrane-specific heparan sulfate proteoglycan core protein [OS=Mus musculus] | 507.28 | 33 | 84 | 998 | 84 | 3707 | 398 | cell organization and biogenesis;transport;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;ER/Golgi | other molecular function | 15530 | Hspg2 | mmu:15530; Q05793 | 0.332090710292395 | 0.382764581022518 | 0.771134174410141 | 0.553652046981626 | 0.208890689478245 | 0.938381933295379 | 0.285967432697218 | 0.908661395894721 | 136795.508290338 | 206406.403199821 | 169825.859706297 | 171009.25706548532 | 3.70110206606215E7 | 4.34630743166815E7 | 4.28074794537461E7 | 4.109385814368304E7 | 2.41165287907714E7 | 1.91842080304052E7 | 2.07659482289725E7 | 2.1355561683383033E7 | 2.10452863152835E7 | 2.06741361608803E7 | 1.52751209810576E7 | 1.8998181152407136E7 | 5927226.99682882 | 1.0580617159021E7 | 8226367.86740312 | 8244737.341084313 | |||
| Q61554 | Fibrillin-1 [OS=Mus musculus] | 499.202 | 38 | 86 | 1117 | 86 | 2873 | 312.1 | cell adhesion;other metabolic processes;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 14118 | ENSMUSG00000027204 | Fbn1 | A2AQ53; mmu:14118; Q60826; Q61554 | Comprehensive IL-17A signaling | Integrin cell surface interactions; Degradation of the extracellular matrix; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; TGF-beta receptor signaling activates SMADs; Molecules associated with elastic fibres | 0.0596853092747711 | 0.0840496117897429 | 0.378389090130589 | 0.84258396038376 | 0.087482121441914 | 0.862063111456553 | 0.0455630470425967 | 0.77820123247099 | 95282.9912894267 | 109686.773968107 | 40225.7464170883 | 81731.837224874 | 5.82457893686458E7 | 6.62931141873392E7 | 3.19536333419291E7 | 5.216417896597137E7 | 2.33066180631659E7 | 1.9035713753758E7 | 2.29784126659734E7 | 2.17735814942991E7 | 2.39841959808407E7 | 2.29999435869113E7 | 1.54925740961197E7 | 2.082557122129057E7 | 2575605.08863811 | 7345083.32475891 | 5514536.56061601 | 5145074.9913376765 |
| Q8BTM8 | Filamin-A [OS=Mus musculus] | 493.069 | 49 | 91 | 915 | 83 | 2647 | 281 | cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;other molecular function | 192176 | ENSMUSG00000031328 | Flna | B7FAV0; O54934; Q7TQI1; Q8BLK1; Q8BTM8; Q8BTN7; Q8VHX5; Q8VHX8; Q99KQ2 | Mapk signaling pathway; Focal adhesion | Platelet degranulation ; Cell-extracellular matrix interactions; RHO GTPases activate PAKs; GP1b-IX-V activation signalling | 0.0844935092512095 | 0.493514006575528 | 0.170420349138264 | 0.67528135146603 | 0.946239447314336 | 0.864215513767001 | 0.904360680536565 | 0.8468455705593 | 223080.302738683 | 192779.021360071 | 239583.24348992 | 218480.8558628913 | 1.21506602248127E7 | 1.23160583881327E7 | 9719435.76620134 | 1.1395384793048913E7 | 4325195.00464495 | 4176073.86658823 | 6355593.34436329 | 4952287.405198824 | 1.73054238441738E7 | 1.42527501066511E7 | 1.24998953996761E7 | 1.4686023116833666E7 | 2879720.55833739 | 5479053.39146785 | 4531038.34565544 | 4296604.098486893 |
| P02463 | Collagen alpha-1(IV) chain [OS=Mus musculus] | 487.707 | 70 | 68 | 828 | 68 | 1669 | 160.6 | cell organization and biogenesis;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix | extracellular structural activity;other molecular function | 12826 | ENSMUSG00000031502 | Col4a1 | mmu:12826; P02463; Q3UHJ4; Q3UJE7; Q3UQV2; Q53X35; Q6GQS7; Q6PHB5; Q99LQ8 | Spinal cord injury; Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Laminin interactions; Signaling by PDGF; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions | 0.604225174343649 | 0.68008321917751 | 0.284160251285083 | 0.936818656936794 | 0.483508479481234 | 0.167300285011781 | 0.777395712279767 | 0.224623005929948 | 359769.877634713 | 285958.835932462 | 141085.539092917 | 262271.417553364 | 2.00868956379824E7 | 2.17854047157598E7 | 2.25190928918174E7 | 2.1463797748519864E7 | 4657081.16483192 | 4119739.1632835 | 5084724.84322114 | 4620515.057112186 | 3.91843343162395E7 | 3.69562703398771E7 | 2.33283395840594E7 | 3.3156314746725336E7 | 6193195.94075903 | 1.32557370999003E7 | 7286914.931104 | 8911949.32392111 |
| Q60847 | Collagen alpha-1(XII) chain [OS=Mus musculus] | 480.266 | 40 | 95 | 991 | 95 | 3120 | 340 | cell adhesion;developmental processes | other cell component | 12816 | ENSMUSG00000032332 | Col12a1 | mmu:12816; P70322; Q60847 | Assembly of collagen fibrils and other multimeric structures; Collagen chain trimerization; Collagen degradation | 0.0975092237649803 | 1.8644578313253E-17 | 0.344512840834051 | 0.162753188077458 | 0.119424004207039 | 0.101350980560035 | 0.0103905836841461 | 0.266844028199729 | 98450.5264125119 | 58090.3600627237 | 83999.6481680613 | 80180.17821443231 | 3.34408474370425E7 | 3.89438836318894E7 | 1.74727378978336E7 | 2.9952489655588504E7 | 5.74848700994307E7 | 4.49447732262548E7 | 5.27793485517261E7 | 5.1736330625803865E7 | 1.71723257401258E7 | 1.50709974901674E7 | 1.16453026750935E7 | 1.4629541968462234E7 | 6848854.24799245 | 1.38653609093446E7 | 1.0899125462023E7 | 1.0537780206453351E7 | ||
| Q8VDD5 | Myosin-9 [OS=Mus musculus] | 418.364 | 45 | 73 | 827 | 60 | 1960 | 226.2 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;stress response;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;other molecular function | 17886 | ENSMUSG00000022443 | Myh9 | mmu:17886; Q3UHT9; Q3UHU4; Q6KAN6; Q811I2; Q8VDD5 | Primary focal segmental glomerulosclerosis (FSGS) | RHO GTPases activate PAKs; Regulation of actin dynamics for phagocytic cup formation | 0.156498497144098 | 0.0382609387499984 | 0.118876667035285 | 0.15125389278925 | 0.87421335771164 | 0.916542675526027 | 0.91728043005175 | 0.990873516209569 | 107483.529676039 | 153800.887463573 | 39674.4269878413 | 100319.6147091511 | 8783012.74886087 | 9974545.70796386 | 5444477.78467149 | 8067345.413832072 | 4748384.28257292 | 4410554.6604061 | 6370665.87897293 | 5176534.940650649 | 2.10207699044932E7 | 2.09758895852136E7 | 1.72823293907493E7 | 1.9759662960152034E7 | 5517905.75659883 | 9476865.41359831 | 8538625.93793802 | 7844465.70271172 |
| Cont_P02453 | Collagen alpha-1(I) chain OS=Bos taurus OX=9913 GN=COL1A1 PE=1 SV=3 | 414.689 | 43 | 43 | 1208 | 4 | 1463 | 138.9 | cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | 282187 | ENSBTAG00000013103 | COL1A1 | bta:282187; P02453; Q3MHM2 | Inflammatory response pathway; Osteoblast signaling; Focal adhesion | Fibronectin matrix formation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Collagen degradation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; Collagen chain trimerization; GPVI-mediated activation cascade; Platelet Aggregation (Plug Formation); Platelet Adhesion to exposed collagen; GP1b-IX-V activation signalling | 0.800889767710788 | 0.579410556046386 | 0.58548007712969 | 0.839216523231753 | 0.067749585016969 | 0.848119069115724 | 0.108042253370914 | 0.0107964100780951 | 246464.336302772 | 276104.509600215 | 163058.776827813 | 228542.54091026666 | 4343807.62117337 | 4270443.00602544 | 3115927.46864821 | 3910059.36528234 | 3219828.72869598 | 3183952.03023541 | 3383679.40073467 | 3262486.7198886867 | 941743.224351002 | 1075861.66368366 | 756862.710693879 | 924822.5329095138 | 876331.391932507 | 1065336.29340721 | 1364509.18546901 | 1102058.9569362423 |
| Cont_P02769 | Albumin OS=Bos taurus OX=9913 GN=ALB PE=1 SV=4 | 390.555 | 81 | 57 | 7095 | 54 | 607 | 69.2 | stress response;other biological processes | non-structural extracellular;other cell component | nucleic acid binding activity;other molecular function | 280717 | ALB | A5PJX3; bta:280717; O02787; P02769; P04277; Q3SZR2 | 0.520832629933248 | 0.650544967914241 | 0.598172767155558 | 0.497906326712893 | 0.946568086066385 | 0.413798631523592 | 0.846117085258013 | 0.468531677746422 | 3.41035277502904E9 | 3.06531085647989E9 | 1.66716629813739E9 | 2.7142766432154403E9 | 2.0547979326133E9 | 2.37062763488737E9 | 2.78500610382043E9 | 2.4034772237737E9 | 3.09362764542436E9 | 2.55631644026836E9 | 3.07992745656962E9 | 2.9099571807541137E9 | 2.97814649224141E9 | 2.86277256421772E9 | 2.21144220575444E9 | 2.6841204207378564E9 | 2.22855277531216E9 | 3.25384623573346E9 | 1.66052966718895E9 | 2.38097622607819E9 | |||
| P01027 | Complement C3 [OS=Mus musculus] | 388.541 | 53 | 70 | 1148 | 62 | 1663 | 186.4 | cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular;other cell component | signal transduction activity or receptor binding;enzyme regulator activity | 12266 | ENSMUSG00000024164 | C3 | mmu:12266; P01027; Q61370; Q80XP1 | Complement activation, classical pathway; Tyrobp causal network in microglia; Comprehensive IL-17A signaling | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade; Neutrophil degranulation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; G alpha (i) signalling events; Peptide ligand-binding receptors; Alternative complement activation; Activation of C3 and C5 | 0.712660037675161 | 0.729783028721347 | 0.506101547380209 | 0.762068821001752 | 0.939492000987438 | 0.512232143465318 | 0.413470300505934 | 0.991722673088443 | 4040096.73815256 | 3926631.83282415 | 1843021.41157313 | 3269916.660849947 | 4.04154698805798E7 | 4.4896658832648E7 | 4.8335201547635E7 | 4.4549110086954266E7 | 1.80671896153384E7 | 1.47828809765086E7 | 1.7121367805152E7 | 1.6657146132333001E7 | 9.88883606977539E7 | 8.1974398309486E7 | 5.99376709525504E7 | 8.026680998659676E7 | 2.84159228355073E7 | 4.96444404075474E7 | 3.21393016835685E7 | 3.6733221642207734E7 |
| Cont_Q7SIH1 | Alpha-2-macroglobulin OS=Bos taurus OX=9913 GN=A2M PE=1 SV=2 | 370.864 | 53 | 56 | 1089 | 56 | 1510 | 167.5 | non-structural extracellular | enzyme regulator activity;other molecular function | 513856 | ENSBTAG00000018137 | A2M | A8E647; bta:513856; Q7SIH1 | IL-6 signaling pathway | 0.688450665125024 | 0.839052280267302 | 0.731111241255251 | 0.509007335932165 | 0.944154202827561 | 0.540124873725708 | 0.671798309985569 | 0.809503222445875 | 5.71770657169572E7 | 6.35766951637367E7 | 4.19549690627817E7 | 5.423624331449187E7 | 6.46032237401637E7 | 7.37926671048822E7 | 7.2164410166051E7 | 7.018676700369896E7 | 8.06000315293491E7 | 7.23429494984619E7 | 7.40068576999505E7 | 7.564994624258716E7 | 8.7810317845685E7 | 9.50258669209954E7 | 6.46884849507494E7 | 8.250822323914327E7 | 3.96461495018234E7 | 7.63451634810678E7 | 4.10565401116459E7 | 5.23492843648457E7 | ||
| Cont_Q29443 | Serotransferrin OS=Bos taurus OX=9913 GN=TF PE=2 SV=1 | 343.183 | 74 | 48 | 1709 | 46 | 704 | 77.7 | stress response;transport;other biological processes | non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle | other molecular function | 280705 | TF | bta:280705; Q0IIK2; Q29443 | 0.615274986253429 | 0.964709887217926 | 0.600414647182016 | 0.571407162236119 | 0.902231721267411 | 0.105569810421019 | 0.506704636011438 | 0.313748671859839 | 1.71679936327392E8 | 1.91001417946965E8 | 8.41149187199369E7 | 1.48932090998098E8 | 1.24867801818358E8 | 1.55146358811954E8 | 1.88178132242021E8 | 1.5606409762411097E8 | 2.69795837029218E8 | 2.21755859229163E8 | 2.04768415701638E8 | 2.32106703986673E8 | 1.81082969779594E8 | 1.61167381210782E8 | 1.45463022007429E8 | 1.6257112433260167E8 | 1.38609619584445E8 | 1.76572700073531E8 | 9.18433757916485E7 | 1.3567523181654152E8 | |||
| Cont_P07589 | Fibronectin OS=Bos taurus OX=9913 GN=FN1 PE=1 SV=4 | 337.517 | 26 | 47 | 923 | 11 | 2478 | 272 | cell adhesion;cell organization and biogenesis;stress response;developmental processes;other biological processes | non-structural extracellular | signal transduction activity or receptor binding;other molecular function | FN1 | P07589 | 0.714071857030863 | 0.525827426782658 | 0.94971810013306 | 0.802863674292211 | 0.553450172742796 | 0.634088329627404 | 0.35834247597224 | 0.281927255363179 | 142865.797461343 | 209169.389049115 | 146732.075795441 | 166255.75410196633 | 1055759.20189889 | 1052518.92691246 | 748231.640959004 | 952169.9232567847 | 927817.269350189 | 797644.80797335 | 782189.414628216 | 835883.8306505851 | 683356.768802769 | 735882.167003896 | 388557.285212602 | 602598.7403397557 | 334439.098432858 | 506951.879121439 | 606468.327162644 | 482619.7682389803 | ||||
| Q80X90 | Filamin-B [OS=Mus musculus] | 335.882 | 38 | 75 | 608 | 66 | 2602 | 277.7 | cell organization and biogenesis;stress response;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 286940 | ENSMUSG00000025278 | Flnb | E9QNV9; mmu:286940; Q80X90; Q8VHX4; Q8VHX7; Q99KY3 | ISG15 antiviral mechanism | 0.296944306247309 | 0.238365792894698 | 0.254729742039053 | 0.629546282386664 | 0.936411452199724 | 0.897564267605108 | 0.872448101434609 | 0.866446545996913 | 201569.562939035 | 74814.3999578854 | 187488.727848728 | 154624.23024854946 | 5908241.65562211 | 7025090.54357015 | 5213153.27323614 | 6048828.490809467 | 2307098.04671866 | 1545558.91097354 | 3200680.70273347 | 2351112.5534752235 | 8948631.41531232 | 7437294.37435051 | 6391778.7211006 | 7592568.170254476 | 1318356.62479586 | 2409815.97001446 | 1867290.64861647 | 1865154.4144755967 | |
| Cont_P35527 | Keratin, type I cytoskeletal 9 OS=Homo sapiens OX=9606 GN=KRT9 PE=1 SV=3 | 310.424 | 69 | 35 | 915 | 34 | 623 | 62 | cell organization and biogenesis;other biological processes | cytosol;cytoskeleton | cytoskeletal activity | 3857 | ENSG00000171403 | KRT9 | hsa:3857; O00109; P35527; Q0IJ47; Q14665 | Formation of the cornified envelope | 0.836660982916281 | 0.73072258897653 | 0.769556732848094 | 0.964570089320365 | 0.873609880131656 | 0.936669139837906 | 0.516448827835279 | 0.0110179641295352 | 3.00988862408693E7 | 2.22166955848562E7 | 3.53566605858277E7 | 2.9224080803851068E7 | 3.83413938796298E7 | 4.01115354911529E7 | 4.55013850626263E7 | 4.1318104811136335E7 | 3.25056930591839E7 | 3.99576081794461E7 | 2.50556157717982E7 | 3.250630567014273E7 | 4.79768166310243E7 | 2.93517742058567E7 | 7.69722436015544E7 | 5.1433611479478456E7 | 9.27838604678364E7 | 5.6604390657593E7 | 1.31711700890849E8 | 9.369998400542612E7 | |
| Cont_P04264 | Keratin, type II cytoskeletal 1 OS=Homo sapiens OX=9606 GN=KRT1 PE=1 SV=6 | 306.58 | 65 | 45 | 1774 | 36 | 644 | 66 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;other molecular function | 3848 | ENSG00000167768 | KRT1 | B2RA01; hsa:3848; P04264; P85925; P86104; Q14720; Q6GSJ0; Q9H298 | Corticotropin-releasing hormone signaling | Formation of the cornified envelope; Neutrophil degranulation; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.65780924735352 | 0.653826967689551 | 0.631165145316661 | 0.89629386854896 | 0.873609880131656 | 0.770634810212039 | 0.254077056479593 | 5.78940441291519E-5 | 1.31038801811221E8 | 1.49848314576813E8 | 1.81048519054156E8 | 1.5397854514739665E8 | 1.64179912336924E8 | 1.70861004616453E8 | 1.60803236136221E8 | 1.6528138436319932E8 | 1.32005397364365E8 | 1.61355773356369E8 | 1.09071204525108E8 | 1.3414412508194733E8 | 1.84835731298625E8 | 1.38277867637903E8 | 2.0582953187505E8 | 1.7631437693719265E8 | 3.95085049343759E8 | 3.00261678765842E8 | 6.47574942932283E8 | 4.476405570139613E8 |
| P06909 | Complement factor H [OS=Mus musculus] | 292.01 | 49 | 41 | 540 | 41 | 1234 | 139 | cell adhesion;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes | non-structural extracellular;plasma membrane;other membranes;mitochondrion;other cell component | other molecular function | 12628 | ENSMUSG00000026365 | Cfh | mmu:12628; P06909; Q6NZK3 | Regulation of Complement cascade | 0.205200089226065 | 0.0359547312524068 | 1.50457038391225E-17 | 0.329485122608543 | 0.678323397545056 | 0.532399788858771 | 0.750662231008662 | 0.443116920082088 | 45833.2314948132 | 5719.34924483144 | 127074.400703141 | 59542.32714759521 | 9199603.23733176 | 9631512.57691777 | 1.22513356989878E7 | 1.036081717107911E7 | 1.13946236540082E7 | 8948376.12127358 | 1.13575209573925E7 | 1.0566840244224759E7 | 3.40837407850627E7 | 2.84575354110008E7 | 2.55312981422866E7 | 2.9357524779450033E7 | 6857257.31092971 | 1.08034871236965E7 | 7658800.41775084 | 8439848.284125684 | |
| P16546 | Spectrin alpha chain, non-erythrocytic 1 [OS=Mus musculus] | 291.854 | 35 | 74 | 473 | 74 | 2472 | 284.4 | cell organization and biogenesis | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 20740 | ENSMUSG00000057738 | Sptan1 | A3KGU6; A3KGU8; P16546; Q8K380; Q9CT05 | FAS pathway and stress induction of HSP regulation | Neutrophil degranulation; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Interaction between L1 and Ankyrins; COPI-mediated anterograde transport; RHOU GTPase cycle; RHOV GTPase cycle; Caspase-mediated cleavage of cytoskeletal proteins | 0.958962194559628 | 0.786160319109602 | 0.611910908670005 | 0.890289034593217 | 0.929383260195332 | 0.771887919257916 | 0.870511801558508 | 0.852906094467594 | 889916.065158961 | 705414.766907556 | 458549.490375553 | 684626.7741473566 | 4175162.43226982 | 4600176.71769719 | 3155429.78771999 | 3976922.979229001 | 1301153.76848032 | 907755.21332001 | 2072924.21437361 | 1427277.73205798 | 9282178.93349268 | 8610756.12905297 | 6522130.81446154 | 8138355.29233573 | 1477626.07784989 | 2972528.81421804 | 2340149.67970916 | 2263434.85725903 |
| Cont_P13645 | Keratin, type I cytoskeletal 10 OS=Homo sapiens OX=9606 GN=KRT10 PE=1 SV=6 | 286.713 | 62 | 30 | 1322 | 20 | 584 | 58.8 | cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes | plasma membrane;cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;other molecular function | 3858 | ENSG00000186395 | KRT10 | hsa:3858; P13645; Q14664; Q8N175 | Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.600890052902075 | 0.490821286240141 | 0.561934876627864 | 0.941696908693733 | 0.829734761131295 | 0.880940844456856 | 0.246231694954624 | 2.55433624902191E-5 | 8.57039306780817E7 | 1.2308209015436E8 | 1.23973335952419E8 | 1.1091978559495355E8 | 1.09050331614224E8 | 1.30109606828786E8 | 1.02692161896587E8 | 1.13950700113199E8 | 8.73473050095944E7 | 1.23031831133367E8 | 7.19147674496861E7 | 9.409796786421584E7 | 1.29238189237995E8 | 9.43248217623685E7 | 1.03859326412487E8 | 1.0914077913761683E8 | 2.4676744393623E8 | 2.01230291385254E8 | 5.11249836753994E8 | 3.19749190691826E8 | |
| Cont_P35908 | Keratin, type II cytoskeletal 2 epidermal OS=Homo sapiens OX=9606 GN=KRT2 PE=1 SV=2 | 284.975 | 78 | 42 | 1022 | 32 | 639 | 65.4 | cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes | plasma membrane;cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;cytoskeletal activity | 3849 | ENSG00000172867 | KRT2 | hsa:3849; P35908; Q4VAQ2 | Formation of the cornified envelope | 0.499413631103761 | 0.411258958244596 | 0.544106843431104 | 0.933570718645937 | 0.912218866069753 | 0.862063111456553 | 0.309041843038519 | 2.9837536993241E-4 | 2.56957016834685E7 | 6.51011422173888E7 | 5.25056794690703E7 | 4.776750778997586E7 | 3.16465014359267E7 | 4.04662454773149E7 | 3.03458785296059E7 | 3.415287514761583E7 | 2.58420950665494E7 | 4.44581259999837E7 | 1.77732081549674E7 | 2.9357809740500167E7 | 3.88601529372083E7 | 2.41897353529024E7 | 4.54682916268081E7 | 3.617272663897294E7 | 6.73715830359901E7 | 6.38856203067551E7 | 9.79668081708945E7 | 7.640800383787991E7 | |
| Q62059 | Versican core protein [OS=Mus musculus] | 279.715 | 17 | 44 | 1073 | 44 | 3357 | 366.6 | cell adhesion;developmental processes | non-structural extracellular;extracellular matrix;other cell component | other molecular function | Vcan | Q62058; Q62059; Q9CUU0 | ECM proteoglycans; Glycosaminoglycan-protein linkage region biosynthesis; CS/DS degradation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; CS-GAG biosynthesis; DS-GAG biosynthesis | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.854305439376382 | 0.613304974369123 | 0.478009151463064 | 0.783304059803245 | 125473.726574878 | 146060.097046071 | 41031.8651630982 | 104188.56292801573 | 8.44868881898379E7 | 1.01917408783468E8 | 9.76252353450265E7 | 9.467651077277745E7 | 1.00104936351016E8 | 8.17450473009677E7 | 8.92610512588614E7 | 9.037034497028168E7 | 1.04839173391366E8 | 1.06605513712809E8 | 7.38631920533055E7 | 9.510262638582683E7 | 4.44571187520766E7 | 8.14544543672178E7 | 5.09261453344577E7 | 5.89459061512507E7 | |||
| P10493 | Nidogen-1 [OS=Mus musculus] | 275.191 | 43 | 42 | 852 | 42 | 1245 | 136.5 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | other molecular function | 18073 | ENSMUSG00000005397 | Nid1 | mmu:18073; P10493; Q3TKX9; Q8BQI3; Q8C3U8; Q8C9P6 | Laminin interactions; Degradation of the extracellular matrix | 1.65082956259427E-17 | 1.8644578313253E-17 | 0.251140212279038 | 0.461941385639594 | 0.013229256333524 | 0.604382524464811 | 1.0740690550749E-5 | 0.781368126060588 | 439897.722361698 | 266111.080129006 | 261357.080833752 | 322455.2944414853 | 1.30583493944604E8 | 1.41493313555848E8 | 1.08068734992402E8 | 1.2671518083095133E8 | 1.1764867041349E8 | 1.23903817347262E8 | 1.22059347123012E8 | 1.2120394496125467E8 | 3.85653673006923E7 | 3.40794335543811E7 | 2.32700802472122E7 | 3.1971627034095198E7 | 6809358.71273179 | 1.16807558295498E7 | 8950100.03941293 | 9146738.193898173 | |
| O88207 | Collagen alpha-1(V) chain [OS=Mus musculus] | 275.025 | 46 | 52 | 413 | 44 | 1838 | 183.6 | cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes | extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12831 | ENSMUSG00000026837 | Col5a1 | A3KGE3; mmu:12831; O88207; Q3UG94; Q6F6B0 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | ECM proteoglycans; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; MET activates PTK2 signaling | 1.65082956259427E-17 | 1.8644578313253E-17 | 0.268653947705267 | 0.311207075116757 | 0.189625712887896 | 0.848119069115724 | 0.302671730722046 | 0.809503222445875 | 12502.6007438316 | 105962.872602761 | 122701.039249758 | 80388.83753211687 | 8585864.47184676 | 9052435.86465399 | 8047799.6262338 | 8562033.320911517 | 3715509.90739661 | 3183478.03245453 | 3834509.14396516 | 3577832.3612721 | 3548034.64380386 | 3694879.64301103 | 2052789.86607006 | 3098568.0509616495 | 910135.702053452 | 1926767.56075777 | 1322438.93167649 | 1386447.3981625708 |
| P37889 | Fibulin-2 [OS=Mus musculus] | 269.894 | 43 | 37 | 791 | 37 | 1221 | 131.7 | other biological processes | non-structural extracellular | other molecular function | 14115 | ENSMUSG00000064080 | Fbln2 | G5E8B3; mmu:14115; P37889; Q9WUI2 | Molecules associated with elastic fibres | 1.65082956259427E-17 | 0.0640195441309023 | 0.201227492083465 | 0.255240026777032 | 0.453005417011507 | 0.803447472095846 | 0.290132264062119 | 0.809503222445875 | 404936.27628206 | 303410.824570497 | 379728.902265123 | 362692.0010392267 | 7.35240092421165E7 | 8.16716617206073E7 | 8.54486063918813E7 | 8.021475911820169E7 | 7.34239875271171E7 | 6.18846762513378E7 | 6.13955038440774E7 | 6.556805587417743E7 | 5.64407337496573E7 | 5.35180097543675E7 | 3.80873889057723E7 | 4.93487108032657E7 | 2.21115750486307E7 | 3.84218730879294E7 | 2.96696416762988E7 | 3.00676966042863E7 | |
| Q8VHX6 | Filamin-C [OS=Mus musculus] | 249.498 | 31 | 65 | 425 | 56 | 2726 | 290.9 | cell organization and biogenesis;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity | 68794 | ENSMUSG00000068699 | Flnc | B2RY80; B9EKT2; mmu:68794; Q6PAI6; Q8VHX6; Q9JJ38 | Cell-extracellular matrix interactions | 0.562594032195739 | 0.719627996749639 | 0.962331548063155 | 0.57290809187594 | 0.976873891151678 | 0.96786708205164 | 0.933437821008547 | 0.80954066750699 | 362673.376414211 | 453714.7830589 | 401875.758519269 | 406087.97266412666 | 2896613.16388353 | 1997446.07055639 | 1374740.24453431 | 2089599.8263247435 | 898320.393102247 | 899851.262035181 | 1251187.76236098 | 1016453.1391661359 | 4619845.64928082 | 4224920.76413233 | 4533386.9985568 | 4459384.47065665 | 1245417.60281572 | 1275359.84004796 | 889222.28002913 | 1136666.5742976035 | |
| Q04857 | Collagen alpha-1(VI) chain [OS=Mus musculus] | 248.981 | 44 | 33 | 588 | 33 | 1025 | 108.4 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component | other molecular function | 12833 | ENSMUSG00000001119 | Col6a1 | mmu:12833; Q04857 | ECM proteoglycans; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Signaling by PDGF; NCAM1 interactions | 0.2534363617947 | 0.392208211277376 | 0.962331548063155 | 0.971216996811237 | 0.0353343473113635 | 0.97504218639442 | 0.115965329440656 | 0.380888676065133 | 99442.7570537982 | 67304.0023261046 | 63848.8638629308 | 76865.2077476112 | 6.50338448192604E7 | 8.11264443817216E7 | 6.12675161034549E7 | 6.914260176814564E7 | 5.28406132873544E7 | 4.53711044962942E7 | 5.19951028566589E7 | 5.0068940213435836E7 | 2.08305860584001E7 | 2.24322225654869E7 | 1.63957751491443E7 | 1.9886194591010433E7 | 1.00181099527419E7 | 1.94360212112643E7 | 1.39653990737858E7 | 1.4473176745930666E7 | |
| Cont_Q2UVX4 | Complement C3 OS=Bos taurus OX=9913 GN=C3 PE=1 SV=2 | 247.154 | 39 | 55 | 851 | 47 | 1661 | 187.1 | cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular;other cell component | signal transduction activity or receptor binding;enzyme regulator activity | 280677 | ENSBTAG00000017280 | C3 | bta:280677; Q2KIZ4; Q2UVX4 | Complement and coagulation cascades; Complement activation, classical pathway | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Neutrophil degranulation; Peptide ligand-binding receptors; G alpha (i) signalling events; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade; Alternative complement activation; Activation of C3 and C5 | 0.615680953989958 | 0.798729234704005 | 0.573945385766997 | 0.506364847510615 | 0.87421335771164 | 0.291700662163587 | 0.591028379533681 | 0.448532796991499 | 1.66248121121728E7 | 1.69271139045693E7 | 1.05083515570206E7 | 1.4686759191254234E7 | 1.25526666866144E7 | 1.76991579704635E7 | 1.56235874907449E7 | 1.5291804049274266E7 | 1.80944158276855E7 | 1.82336027421103E7 | 1.90370193770683E7 | 1.84550126489547E7 | 1.87583360164926E7 | 1.78001813666833E7 | 1.18248646641963E7 | 1.6127794015790733E7 | 9025681.5960692 | 1.79617171787325E7 | 8899645.14317005 | 1.196234797265725E7 |
| Q62261 | Spectrin beta chain, non-erythrocytic 1 [OS=Mus musculus] | 244.684 | 30 | 61 | 398 | 61 | 2363 | 274.1 | cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 20742 | ENSMUSG00000020315 | Sptbn1 | A2AFU1; mmu:20742; Q3TEM7; Q5SQL8; Q5SQL9; Q62261; Q9QWJ7 | COPI-mediated anterograde transport; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; RHOU GTPase cycle; Interaction between L1 and Ankyrins; RHOV GTPase cycle | 0.69394578118832 | 0.776437620310661 | 0.693719649766064 | 0.831411077141515 | 0.937876734191067 | 0.86315143463057 | 0.664971370235365 | 0.953305976192702 | 373834.445440549 | 533726.562973047 | 569801.107945045 | 492454.03878621367 | 3103526.47805657 | 3181731.16602619 | 2477755.42998989 | 2921004.358024217 | 796281.087102098 | 609431.872132576 | 1356947.15467432 | 920886.7046363313 | 7745784.08821259 | 6610112.71623617 | 4897418.35730506 | 6417771.720584608 | 1743474.26371724 | 2723698.32906552 | 2432765.02616441 | 2299979.2063157237 | |
| Q640N1 | Adipocyte enhancer-binding protein 1 [OS=Mus musculus] | 239.707 | 38 | 34 | 648 | 34 | 1128 | 128.3 | protein metabolism;other biological processes | nucleus;other cell component | nucleic acid binding activity;other molecular function | 11568 | ENSMUSG00000020473 | Aebp1 | mmu:11568; O88442; Q3TVV5; Q3TWA7; Q3TX56; Q3TXB2; Q5NCI9; Q61281; Q640N1 | 0.269326617826563 | 0.0457359864845759 | 0.605387748357992 | 0.631359014803774 | 0.534291750451691 | 0.760992448481534 | 0.145805028390539 | 0.963436677882021 | 3560033.84712119 | 4696620.34449178 | 6275149.80645163 | 4843934.666021533 | 4.59930845855363E7 | 5.69735867783534E7 | 2.04646374454636E7 | 4.1143769603117764E7 | 3.80233154774145E7 | 4.02615711999708E7 | 4.03854487434811E7 | 3.9556778473622136E7 | 3.40966164303398E7 | 3.7490792004469E7 | 2.41166240785119E7 | 3.1901344171106894E7 | 1.40971982755857E7 | 2.68643149803103E7 | 1.4983671743246E7 | 1.8648394999714002E7 | ||
| P57780 | Alpha-actinin-4 [OS=Mus musculus] | 239.42 | 58 | 45 | 483 | 30 | 912 | 104.9 | cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes | cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 60595 | ENSMUSG00000054808 | Actn4 | mmu:60595; P57780 | Primary focal segmental glomerulosclerosis (FSGS) | Platelet degranulation | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 0.19149089837131 | 0.921882153462399 | 0.795351011232032 | 0.968364585136618 | 0.938282411159324 | 5221.79731213346 | 36578.541519335 | 20900.169415734228 | 9107610.67207618 | 1.00453975465233E7 | 1.03378326393571E7 | 9830280.285985528 | 5095419.11923033 | 3409382.50707632 | 5238186.41277381 | 4580996.01302682 | 1.31020350186557E7 | 1.2711162036506E7 | 9162046.18669404 | 1.1658414413951913E7 | 3002316.05426355 | 5816939.08777499 | 4501757.36231035 | 4440337.50144963 | |
| Q7TPR4 | Alpha-actinin-1 [OS=Mus musculus] | 235.529 | 54 | 42 | 511 | 27 | 892 | 103 | cell adhesion;cell organization and biogenesis;other biological processes | plasma membrane;other membranes;cytoskeleton;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function | 109711 | ENSMUSG00000015143 | Actn1 | mmu:109711; Q7TPR4 | Regulation of actin cytoskeleton; Integrin-mediated cell adhesion; Focal adhesion | Platelet degranulation ; RHOF GTPase cycle; RHOBTB2 GTPase cycle; RHOD GTPase cycle; Regulation of cytoskeletal remodeling and cell spreading by IPP complex components | 0.995554138371554 | 0.178726136005694 | 0.819280225722906 | 0.941696908693733 | 0.974207409660283 | 0.744084716394381 | 0.837231569641376 | 0.879972045955715 | 354073.059499792 | 209249.076355465 | 897084.460899514 | 486802.1989182571 | 5526121.35104279 | 6211867.70337129 | 6893436.45630869 | 6210475.170240924 | 2413615.48536692 | 1933168.81934458 | 3229981.90899851 | 2525588.7379033365 | 1.03807818109957E7 | 1.11771340173328E7 | 8282960.99949337 | 9946958.94260729 | 2797115.44078374 | 4939050.64701654 | 3416305.89125481 | 3717490.65968503 |
| P02468 | Laminin subunit gamma-1 [OS=Mus musculus] | 230.882 | 35 | 43 | 454 | 43 | 1607 | 177.2 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | Lamc1 | P02468 | 0.118212047511996 | 0.116315527815218 | 0.459134305737471 | 0.675951294045723 | 0.3041568870489 | 0.877818946381645 | 0.368062651583427 | 0.922276466908065 | 14325.5972836352 | 21883.5466161272 | 18104.5719498812 | 1.5357350900924E7 | 1.57310961044729E7 | 1.74335709018572E7 | 1.61740059690847E7 | 7496762.71625721 | 6775968.90045745 | 7708775.93718172 | 7327169.184632126 | 9245241.37337628 | 9035989.05815721 | 5573559.97495901 | 7951596.802164167 | 2368540.67041914 | 4605215.17131646 | 2765122.91380764 | 3246292.9185144133 | |||||
| Q91ZX7 | Prolow-density lipoprotein receptor-related protein 1 [OS=Mus musculus] | 230.497 | 15 | 57 | 519 | 56 | 4545 | 504.4 | other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;other molecular function | 16971 | Lrp1 | mmu:16971; Q61291; Q91ZX7; Q920Y4 | Statin pathway; Wnt signaling pathway | Scavenging of heme from plasma; Retinoid metabolism and transport | 1.65082956259427E-17 | 0.0181625429641231 | 0.133639440745791 | 0.150830220548111 | 0.687557067265551 | 0.925871264502428 | 0.74148782464906 | 0.901098484497789 | 10237.2255539891 | 51104.3489937616 | 30670.78727387535 | 6875342.47952318 | 6944806.90573824 | 8247481.69257335 | 7355877.025944923 | 4299652.1243919 | 2953538.60705284 | 3392031.85738558 | 3548407.5296101067 | 6405748.2654286 | 5854087.4911046 | 4914685.84613499 | 5724840.5342227295 | 1705219.62694462 | 2981142.11204421 | 2044471.2247951 | 2243610.9879279765 | ||
| Cont_P60712 | Actin, cytoplasmic 1 OS=Bos taurus OX=9913 GN=ACTB PE=1 SV=1 | 225.45 | 70 | 19 | 852 | 2 | 375 | 41.7 | cell organization and biogenesis;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component | enzyme regulator activity;cytoskeletal activity;other molecular function | 100033878; 100135470; 100173832; 101844587; 102139853; 11461; 118833809; 280979; 396526; 403580; 414396; 443052; 450133; 60; 81822 | ENSBTAG00000026199; ENSCAFG00000016020; ENSCAFG00030015381; ENSCAFG00040015695; ENSCPOG00000013467; ENSG00000075624; ENSMAUG00000008763; ENSMUSG00000029580; ENSOARG00040012985; ENSOARG00180022443; ENSOARG00185023855; ENSOARG00215030140; ENSOARG00225009314; ENSPPYG00000017336; ENSPTRG00000018890; ENSRNOG00000034254; ENSSSCG00000007585; ENSSSCG00030003451; ENSSSCG00035038792; ENSSSCG00040049462; ENSSSCG00045027458; ENSSSCG00050065025; ENSSSCG00055012597; ENSSSCG00060019124; ENSSSCG00065037921; ENSSSCG00070011353; ENSSSCG00105030144; ENSSSCG00110026965; ENSSSCG00115013637; ENSSSCG00130033784 | Actb; ACTB | A5D961; A5PKA1; bta:280979; cfa:403580; cpoc:100135470; csab:103246953; ecb:100033878; gga:396526; hsa:60; maua:101844587; mmu:11461; O18840; oas:443052; P02570; P60706; P60707; P60708; P60709; P60710; P60711; P60712; P60713; P70514; P99021; pon:100173832; ptr:450133; Q11209; Q11211; Q3SZD2; Q3TI89; Q3TVP6; Q4L0Y2; Q4R561; Q5R1X3; Q5R582; Q5R6G0; Q64316; Q6QAQ1; Q6ZWM3; Q711N9; Q71FK5; Q75MN2; Q76N69; Q8MIJ0; Q8SPX4; Q95164; Q96B34; Q96HG5; rno:81822; ssc:414396 | FAS pathway and stress induction of HSP regulation; Actin cytoskeleton regulation; Myometrial relaxation and contraction pathways; Focal adhesion; Arrhythmogenic right ventricular cardiomyopathy; Pathogenic Escherichia coli infection; Common pathways underlying drug addiction; Myometrial relaxation and contraction pathways; Focal adhesion; Fas ligand pathway and stress induction of heat shock proteins; Pathogenic Escherichia coli infection; Arrhythmogenic right ventricular cardiomyopathy; Focal adhesion; Myometrial relaxation and contraction pathways; Regulation of actin cytoskeleton; Myometrial relaxation and contraction pathways; Ebola virus infection in host; Acute viral myocarditis; Thermogenesis; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Overlap between signal transduction pathways contributing to LMNA laminopathies; Pleural mesothelioma; Regulation of actin cytoskeleton; Network map of SARS-CoV-2 signaling; Regulation of actin cytoskeleton; Regulation of actin cytoskeleton; Focal adhesion | Formation of the canonical BAF (cBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); Regulation of actin dynamics for phagocytic cup formation; EPH-ephrin mediated repulsion of cells; Formation of annular gap junctions; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; RHO GTPases Activate Formins; RHOF GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; B-WICH complex positively regulates rRNA expression; Regulation of CDH1 Function; Formation of the dystrophin-glycoprotein complex (DGC); Formation of the canonical BAF (cBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); RHO GTPases Activate WASPs and WAVEs; UCH proteinases; DNA Damage Recognition in GG-NER; Formation of the non-canonical BAF (ncBAF) complex; RHO GTPases activate IQGAPs; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Cell-extracellular matrix interactions; MAP2K and MAPK activation; Interaction between L1 and Ankyrins; RHOF GTPase cycle; DNA Damage Recognition in GG-NER; MAP2K and MAPK activation; RHO GTPases Activate Formins; Clathrin-mediated endocytosis; UCH proteinases; RHOF GTPase cycle; DNA Damage Recognition in GG-NER; EPH-ephrin mediated repulsion of cells; VEGFA-VEGFR2 Pathway; Regulation of actin dynamics for phagocytic cup formation; Adherens junctions interactions; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); RHO GTPases Activate WASPs and WAVEs; B-WICH complex positively regulates rRNA expression; Regulation of CDH1 Function; EPHB-mediated forward signaling; Formation of the non-canonical BAF (ncBAF) complex; Formation of the canonical BAF (cBAF) complex; Formation of annular gap junctions; RHO GTPases activate IQGAPs; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; RHO GTPases Activate WASPs and WAVEs; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RHO GTPases activate IQGAPs; RHO GTPases Activate Formins; RHOF GTPase cycle; Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs); B-WICH complex positively regulates rRNA expression; Signaling by BRAF and RAF1 fusions; UCH proteinases; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; VEGFA-VEGFR2 Pathway; Formation of the dystrophin-glycoprotein complex (DGC); Factors involved in megakaryocyte development and platelet production; Regulation of MITF-M-dependent genes involved in pigmentation; Formation of the canonical BAF (cBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); EPH-ephrin mediated repulsion of cells; HATs acetylate histones; Interaction between L1 and Ankyrins; Prefoldin mediated transfer of substrate to CCT/TriC; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Adherens junctions interactions; Regulation of CDH1 Function; Formation of the non-canonical BAF (ncBAF) complex; DNA Damage Recognition in GG-NER; Formation of the polybromo-BAF (pBAF) complex; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Formation of annular gap junctions; Folding of actin by CCT/TriC; Cell-extracellular matrix interactions; MAP2K and MAPK activation; RHO GTPases Activate Formins; Recycling pathway of L1; RHO GTPases activate IQGAPs; Clathrin-mediated endocytosis; Formation of the dystrophin-glycoprotein complex (DGC); EPHB-mediated forward signaling; UCH proteinases; B-WICH complex positively regulates rRNA expression; Adherens junctions interactions; Formation of the non-canonical BAF (ncBAF) complex; Formation of annular gap junctions; Formation of the polybromo-BAF (pBAF) complex; VEGFA-VEGFR2 Pathway; Cell-extracellular matrix interactions; RHO GTPases Activate WASPs and WAVEs; Regulation of CDH1 Function; Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; UCH proteinases; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); Formation of the polybromo-BAF (pBAF) complex; B-WICH complex positively regulates rRNA expression; DNA Damage Recognition in GG-NER; Formation of the canonical BAF (cBAF) complex; RHO GTPases Activate Formins; Regulation of CDH1 Function; Interaction between L1 and Ankyrins; RHOF GTPase cycle; Formation of the non-canonical BAF (ncBAF) complex; Adherens junctions interactions; Formation of the dystrophin-glycoprotein complex (DGC); VEGFA-VEGFR2 Pathway; RHO GTPases Activate WASPs and WAVEs; Cell-extracellular matrix interactions; EPHB-mediated forward signaling; MAP2K and MAPK activation; Recycling pathway of L1; RHO GTPases activate IQGAPs; Formation of annular gap junctions; B-WICH complex positively regulates rRNA expression; UCH proteinases; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); MAP2K and MAPK activation; Formation of the polybromo-BAF (pBAF) complex; RHO GTPases Activate Formins; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases Activate WASPs and WAVEs; Formation of the dystrophin-glycoprotein complex (DGC); VEGFA-VEGFR2 Pathway; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; DNA Damage Recognition in GG-NER; RHOF GTPase cycle; Cell-extracellular matrix interactions; Adherens junctions interactions; Formation of the non-canonical BAF (ncBAF) complex; Formation of the canonical BAF (cBAF) complex; RHO GTPases activate IQGAPs; Regulation of CDH1 Function; Gap junction degradation; Formation of annular gap junctions; Regulation of actin dynamics for phagocytic cup formation; RHOF GTPase cycle; Clathrin-mediated endocytosis; RHO GTPases Activate Formins; Cell-extracellular matrix interactions; VEGFA-VEGFR2 Pathway; Adherens junctions interactions; RHO GTPases activate IQGAPs; UCH proteinases; EPHB-mediated forward signaling; MAP2K and MAPK activation; RHO GTPases Activate WASPs and WAVEs; Formation of the dystrophin-glycoprotein complex (DGC); Formation of annular gap junctions; Formation of the canonical BAF (cBAF) complex; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of the non-canonical BAF (ncBAF) complex; Regulation of CDH1 Function | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.946568086066385 | 0.994348552930242 | 0.963278515868644 | 0.938282411159324 | 1924782.99006244 | 2098949.09709163 | 1966246.27612296 | 1996659.4544256767 | 6.9333476629433E7 | 7.92679608662888E7 | 4.66219167617927E7 | 6.5074451419171505E7 | 4.31411746831055E7 | 4.48147974340301E7 | 5.69102455002969E7 | 4.828873920581084E7 | 1.21577893646273E8 | 1.207324829685E8 | 8.72162161647777E7 | 1.0984219759318356E8 | 3.75040107769213E7 | 6.67519874410893E7 | 5.58171302270344E7 | 5.335770948168167E7 |
| P63260 | Actin, cytoplasmic 2 [OS=Mus musculus] | 217.791 | 70 | 19 | 831 | 2 | 375 | 41.8 | cell organization and biogenesis;stress response;developmental processes;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 11465 | ENSMUSG00000062825 | Actg1 | mmu:11465; P02571; P14104; P63260; P99022 | Myometrial relaxation and contraction pathways; Regulation of actin cytoskeleton; Focal adhesion | Platelet degranulation ; RHO GTPases activate IQGAPs; Adherens junctions interactions; Regulation of CDH1 Function; RHO GTPases Activate Formins; Regulation of actin dynamics for phagocytic cup formation; Interaction between L1 and Ankyrins; MAP2K and MAPK activation; Recycling pathway of L1; Clathrin-mediated endocytosis; Formation of the dystrophin-glycoprotein complex (DGC); EPHB-mediated forward signaling; RHOF GTPase cycle; Formation of annular gap junctions; VEGFA-VEGFR2 Pathway; Cell-extracellular matrix interactions; RHO GTPases Activate WASPs and WAVEs; RHOBTB2 GTPase cycle | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.85271451854395 | 0.901789796153066 | 0.731487178650893 | 0.819844267712751 | 345218.530665522 | 243712.893345201 | 175067.879334021 | 254666.434448248 | 138179.400499307 | 114235.784978709 | 184680.44906409 | 145698.54484736864 | 283414.957020267 | 357431.419092683 | 129167.257177683 | 256671.2110968777 | 47386.9835565671 | 139954.449837086 | 191405.076269325 | 126248.83655432604 | ||||
| P33434 | 72 kDa type IV collagenase [OS=Mus musculus] | 212.03 | 56 | 30 | 889 | 30 | 662 | 74.1 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes | extracellular matrix;plasma membrane;other membranes;cytoskeleton;mitochondrion;nucleus;other cell component | other molecular function | 17390 | ENSMUSG00000031740 | Mmp2 | mmu:17390; P33434 | Lung fibrosis; IL-3 signaling pathway; Matrix metalloproteinases | Collagen degradation; Extra-nuclear estrogen signaling; EPH-ephrin mediated repulsion of cells; Activation of Matrix Metalloproteinases | 0.372996577396536 | 0.964209443670126 | 0.342075680986172 | 0.708142491896103 | 0.993994198406889 | 0.459747209584207 | 0.34519376377552 | 0.809503222445875 | 1.45817945044039E7 | 3.99854546791863E7 | 2.31586213408419E7 | 2.5908623508144036E7 | 6.16168347215595E7 | 6.71128653428481E7 | 5.47627512450794E7 | 6.116415043649567E7 | 2.153095933586E7 | 2.04088973517033E7 | 2.1514079157928E7 | 2.11513119484971E7 | 9.59427020238632E7 | 8.49468673692442E7 | 8.11217362792938E7 | 8.73371018908004E7 | 3.5725700482165E7 | 6.85636819548367E7 | 5.65046943814106E7 | 5.359802560613743E7 |
| P19096 | Fatty acid synthase [OS=Mus musculus] | 203.372 | 23 | 48 | 335 | 48 | 2504 | 272.3 | other metabolic processes;stress response;other biological processes | plasma membrane;other membranes;cytosol;ER/Golgi;other cell component | other molecular function | 14104 | ENSMUSG00000025153 | Fasn | B1ATU8; mmu:14104; P19096; Q6PB72; Q8C4Z0; Q9EQR0 | Fatty acid biosynthesis; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-9 fatty acid synthesis; Elongation of (very) long chain fatty acids | Fatty acyl-CoA biosynthesis; Vitamin B5 (pantothenate) metabolism | 0.66189768147619 | 0.847457711018997 | 0.951921622352553 | 0.605074788683686 | 0.87421335771164 | 0.994834213681465 | 0.746782404466558 | 0.990873516209569 | 48161.514825801 | 157425.136778521 | 102793.32580216101 | 3018838.26514359 | 3331564.42510829 | 1838171.31939824 | 2729524.669883373 | 1125050.80259593 | 1067574.24276956 | 1976727.22395058 | 1389784.0897720233 | 3354008.01034064 | 3348654.9716265 | 2283763.91979924 | 2995475.6339221266 | 618361.207888453 | 1151575.74161029 | 908323.020723558 | 892753.3234074336 | |
| Cont_Q3SZ57 | Alpha-fetoprotein OS=Bos taurus OX=9913 GN=AFP PE=2 SV=1 | 202.89 | 62 | 30 | 1153 | 29 | 610 | 68.5 | other metabolic processes;developmental processes;other biological processes | non-structural extracellular;other cell component | other molecular function | 506011 | ENSBTAG00000017131 | AFP | bta:506011; Q3SZ57 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 0.540832988168188 | 0.82964085881652 | 0.605387748357992 | 0.553772240900005 | 0.938859506774495 | 0.15729598575093 | 0.699570390946254 | 0.323545662226049 | 4.4629857016799E7 | 4.39639700572647E7 | 2.72178105183923E7 | 3.8603879197485335E7 | 3.15168703669999E7 | 4.26075077823651E7 | 3.4328683389093E7 | 3.6151020512819335E7 | 4.8541823037709E7 | 4.32960721364381E7 | 4.4115949306695E7 | 4.5317948160280704E7 | 4.61564880446121E7 | 4.7548077639711E7 | 3.504265434565E7 | 4.2915740009991035E7 | 3.01476017178829E7 | 5.24042356620578E7 | 2.7823391939759E7 | 3.679174310656657E7 | |
| P48678 | Prelamin-A/C [OS=Mus musculus] | 202.607 | 60 | 37 | 529 | 36 | 665 | 74.2 | cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes | other membranes;cytoskeleton;nucleus;other cell component | other molecular function | 16905 | ENSMUSG00000028063 | Lmna | B3RH23; B3RH24; mmu:16905; P11516; P48678; P97859; Q3TIH0; Q3TTS8; Q3U733; Q3U7I5; Q3UCA0; Q3UCJ8; Q3UCU3; Q91WF2; Q9DC21 | Adipogenesis genes; FAS pathway and stress induction of HSP regulation | 1.65082956259427E-17 | 0.00670345592293191 | 0.139423967594304 | 1.70336894001643E-17 | 0.236076921565588 | 0.77212820363828 | 0.901149690306505 | 0.00692305873191716 | 56886.7483713492 | 69336.1384695612 | 100943.444664856 | 75722.11050192213 | 1.29312831685903E7 | 1.22006597313063E7 | 8045013.512583 | 1.1058985470826533E7 | 3337288.2268023 | 3262868.75019265 | 5804803.63611667 | 4134986.871037207 | 6.75536277126862E7 | 5.59333072922179E7 | 3.75993669940438E7 | 5.369543399964929E7 | 4234323.21548912 | 7210898.93259597 | 7422846.33935557 | 6289356.16248022 | |
| Q02788 | Collagen alpha-2(VI) chain [OS=Mus musculus] | 202.37 | 41 | 36 | 585 | 36 | 1034 | 110.3 | cell adhesion;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component | other molecular function | 12834 | ENSMUSG00000020241 | Col6a2 | mmu:12834; Q02788; Q05505; Q8C972; Q8K229 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | ECM proteoglycans; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation | 0.175734701097799 | 1.8644578313253E-17 | 0.633123216104285 | 0.767312384697355 | 0.156641881403766 | 0.880899056945259 | 0.0961283818482991 | 0.809503222445875 | 66343.4096791777 | 224638.480326659 | 72730.0086108415 | 121237.29953889274 | 5.06665581594054E7 | 6.05623117299827E7 | 4.51585075606234E7 | 5.21291258166705E7 | 4.3575871784427E7 | 3.72580130101725E7 | 4.32608904810994E7 | 4.136492509189963E7 | 2.4375983761655E7 | 2.22548052919965E7 | 1.51565723805374E7 | 2.0595787144729633E7 | 7758608.50160191 | 1.64425759910943E7 | 1.09937351728106E7 | 1.173163988850227E7 |
| P97927 | Laminin subunit alpha-4 [OS=Mus musculus] | 199.33 | 30 | 41 | 409 | 41 | 1816 | 201.7 | cell adhesion;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | signal transduction activity or receptor binding | 16775 | ENSMUSG00000019846 | Lama4 | mmu:16775; O88785; P70409; P97927; Q14BF2 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Formation of the dystrophin-glycoprotein complex (DGC); Laminin interactions; MET activates PTK2 signaling | 0.496649188935323 | 0.645007535999596 | 0.952104483873957 | 0.825047045401531 | 0.329011090732691 | 0.929291541980042 | 0.50594120050135 | 0.819844267712751 | 540030.170801593 | 370746.050286439 | 259459.878107817 | 390078.69973194966 | 8261193.64464048 | 1.06712284071143E7 | 1.21929154576081E7 | 1.037511250312096E7 | 5309597.35327991 | 4688186.1422195 | 5379156.74886131 | 5125646.74812024 | 6459712.32980478 | 5951943.81149588 | 4870147.4483696 | 5760601.1965567535 | 2775962.47504545 | 3878847.28463652 | 2541823.46940274 | 3065544.409694903 |
| P20152 | Vimentin [OS=Mus musculus] | 183.446 | 60 | 29 | 762 | 27 | 466 | 53.7 | cell organization and biogenesis;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component | cytoskeletal activity;nucleic acid binding activity;other molecular function | 22352 | ENSMUSG00000026728 | Vim | mmu:22352; O08704; P20152; Q8CCH1 | Spinal cord injury; Primary focal segmental glomerulosclerosis (FSGS); Alpha 6 beta 4 integrin signaling pathway | Aggrephagy; Striated Muscle Contraction; Caspase-mediated cleavage of cytoskeletal proteins; RHOBTB1 GTPase cycle | 1.65082956259427E-17 | 0.0955146622024883 | 1.50457038391225E-17 | 0.137621774180062 | 0.873609880131656 | 0.0297998664849654 | 0.840672080806375 | 0.0332723373064956 | 573727.34417641 | 968981.536762911 | 1794707.43115169 | 1112472.104030337 | 4.14069582585024E7 | 3.33312643886138E7 | 2.54656192896882E7 | 3.3401280645601466E7 | 6941733.99810384 | 6173483.46835617 | 8980531.63051753 | 7365249.698992513 | 8.80704815958352E7 | 8.07026224155391E7 | 5.51524218564722E7 | 7.464184195594883E7 | 6861556.37440952 | 1.68923991921504E7 | 1.5029979690535E7 | 1.292797841903164E7 |
| Q64727 | Vinculin [OS=Mus musculus] | 182.753 | 50 | 45 | 419 | 45 | 1066 | 116.6 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | plasma membrane;other membranes;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 22330 | ENSMUSG00000021823 | Vcl | mmu:22330; Q64727; Q8BP32; Q8BS46; Q922C5; Q922D9 | Primary focal segmental glomerulosclerosis (FSGS); IL-3 signaling pathway; Regulation of actin cytoskeleton; Integrin-mediated cell adhesion; Focal adhesion | Neutrophil degranulation; High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells; Platelet degranulation ; MAP2K and MAPK activation; Smooth Muscle Contraction; Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells; Regulation of CDH1 Function | 0.208404050858596 | 0.190838415616571 | 0.238791978742132 | 0.504745711776551 | 0.964629994744883 | 0.878264980963866 | 0.977491813528386 | 0.958518237573655 | 199164.849916128 | 87100.0128702587 | 92185.322880836 | 126150.06188907423 | 5675245.0989599 | 5838625.66584249 | 3008640.49360623 | 4840837.086136207 | 1870082.63283096 | 1414114.90526218 | 2577750.73562883 | 1953982.7579073233 | 7844023.43396073 | 7226639.25078312 | 5204108.91618431 | 6758257.200309387 | 1587883.53032107 | 3146179.30802337 | 2343388.9049214 | 2359150.5810886133 |
| Q8K4G1 | Latent-transforming growth factor beta-binding protein 4 [OS=Mus musculus] | 180.216 | 27 | 29 | 318 | 29 | 1666 | 178.5 | cell-cell signaling;cell organization and biogenesis;transport;signal transduction | non-structural extracellular;extracellular matrix | other molecular function | 108075 | ENSMUSG00000040488 | Ltbp4 | E9QPD9; mmu:108075; Q8K4G0; Q8K4G1 | TGF-beta receptor signaling activates SMADs; Molecules associated with elastic fibres | 0.308350896322176 | 0.362779483059131 | 1.50457038391225E-17 | 0.170566190602959 | 0.775297640004946 | 0.958956615096849 | 0.703189639676216 | 0.915193515309545 | 20541.0495723262 | 79596.1275426221 | 50068.58855747415 | 2657106.34177438 | 3398147.96764637 | 1365787.73467607 | 2473680.681365607 | 1578272.63307431 | 1205878.60177515 | 1625778.79640944 | 1469976.6770863 | 7998382.13678965 | 8274900.61088866 | 5600614.51816097 | 7291299.088613093 | 1154237.54308251 | 3609675.59166937 | 3209012.09868788 | 2657641.7444799202 | ||
| Q68FD5 | Clathrin heavy chain 1 [OS=Mus musculus] | 180.117 | 32 | 43 | 363 | 43 | 1675 | 191.4 | cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes | plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component | nucleic acid binding activity;other molecular function | 67300 | ENSMUSG00000047126 | Cltc | mmu:67300; Q68FD5 | IL-7 signaling pathway; Kit receptor signaling pathway | MHC class II antigen presentation; Recycling pathway of L1; Cargo recognition for clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis; LDL clearance; Retrograde neurotrophin signalling; Formation of annular gap junctions; Lysosome Vesicle Biogenesis; WNT5A-dependent internalization of FZD4; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation; RHOU GTPase cycle; RHOV GTPase cycle | 0.4248536990637 | 0.198232028950426 | 1.50457038391225E-17 | 0.413413145615294 | 0.688274955487563 | 0.840666598828607 | 0.946476383814868 | 0.835383236382767 | 19752.350121194 | 9410.067942265 | 14581.209031729499 | 2001079.20697008 | 2709198.63758679 | 1592899.41627153 | 2101059.0869428 | 1121542.74388673 | 1205380.43272811 | 1952895.490984 | 1426606.2225329466 | 7620271.96644723 | 6531411.29627789 | 6339405.19264676 | 6830362.818457293 | 1288866.59437226 | 2734753.66820203 | 2211269.42731124 | 2078296.563295177 | |
| P02469 | Laminin subunit beta-1 [OS=Mus musculus] | 179.863 | 27 | 40 | 429 | 39 | 1786 | 197 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;nucleus;other cell component | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 16777 | ENSMUSG00000002900 | Lamb1 | E9PXZ9; P02469 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Inflammatory response pathway; Alpha 6 beta 4 integrin signaling pathway; Focal adhesion | 0.205801242418232 | 0.341417478664423 | 0.526489846375643 | 0.891178501081124 | 0.269583968882479 | 0.900334730044572 | 0.356773085915651 | 0.98779298590131 | 1.07332672254E7 | 1.09845016908001E7 | 9663847.07936098 | 1.0460538665187027E7 | 1.70142446901215E7 | 1.73820787777271E7 | 2.08268192848537E7 | 1.8407714250900764E7 | 1.23074043806854E7 | 1.3842748821146E7 | 1.68288599063313E7 | 1.4326337702720901E7 | 1.20697658178524E7 | 1.33872705970957E7 | 9031275.37365186 | 1.149610392953332E7 | 2.54341447554609E7 | 1.6513199650281E7 | 2.12878061302996E7 | 2.1078383512013834E7 | |
| Q01853 | Transitional endoplasmic reticulum ATPase [OS=Mus musculus] | 179.055 | 52 | 32 | 411 | 32 | 806 | 89.3 | cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;other biological processes | other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;enzyme regulator activity;other molecular function | 269523 | ENSMUSG00000028452 | Vcp | mmu:269523; Q01853; Q3TFH9; Q3TIM2; Q3TXN9; Q6PI18; Q8BSR6; Q8CEG4 | IL-9 signaling pathway | RHOH GTPase cycle; Neutrophil degranulation; Protein methylation; Ovarian tumor domain proteases; Neddylation; ABC-family proteins mediated transport; Translesion Synthesis by POLH; Hedgehog ligand biogenesis; KEAP1-NFE2L2 pathway; HSF1 activation; N-glycan trimming in the ER and Calnexin/Calreticulin cycle; Josephin domain DUBs | 0.915230778358139 | 0.645007535999596 | 0.808626104853287 | 0.953867932777128 | 0.953038161729767 | 0.877818946381645 | 0.901149690306505 | 0.737824045087029 | 462345.280919521 | 876653.458620268 | 526426.850526767 | 621808.5300221853 | 1.01571081063743E7 | 9889323.38925712 | 7942233.31155878 | 9329554.935730066 | 4702185.44070802 | 4580279.55870278 | 6732778.24078372 | 5338414.413398174 | 1.50535993864462E7 | 1.350776734351E7 | 9751498.62422888 | 1.2770955118061693E7 | 3881002.94215154 | 5380991.32313934 | 4128956.06599177 | 4463650.11042755 |
| Q03350 | Thrombospondin-2 [OS=Mus musculus] | 178.303 | 35 | 30 | 328 | 29 | 1172 | 129.8 | cell adhesion;other biological processes | non-structural extracellular;extracellular matrix;other cell component | other molecular function | 21826 | ENSMUSG00000023885 | Thbs2 | mmu:21826; Q03350; Q8CG21 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Signaling by PDGF; O-glycosylation of TSR domain-containing proteins | 0.425958502904743 | 0.861805134687803 | 0.49027994509233 | 0.535702081245677 | 0.792896707923278 | 0.900334730044572 | 0.620448351319483 | 0.80954066750699 | 2258622.92192986 | 2382783.54746756 | 1148078.18193404 | 1929828.2171104867 | 1.31796330485542E7 | 1.5104624453426E7 | 5024405.63191042 | 1.1102887711296873E7 | 7531099.32555027 | 7013388.1367688 | 7773703.92822199 | 7439397.130180354 | 1.11743686938308E7 | 1.16923792648853E7 | 8892616.7561804 | 1.05864549049655E7 | 2163159.37338424 | 5673668.48605754 | 4798999.04450137 | 4211942.301314384 |
| Q80YX1 | Tenascin [OS=Mus musculus] | 175.9 | 28 | 43 | 191 | 43 | 2110 | 231.7 | cell adhesion;cell-cell signaling;cell organization and biogenesis;stress response;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | signal transduction activity or receptor binding;other molecular function | 21923 | ENSMUSG00000028364 | Tnc | mmu:21923; Q64706; Q80YX1; Q80YX2 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Integrin cell surface interactions; ECM proteoglycans; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 0.117980756369098 | 0.827773046590747 | 0.560799429150649 | 0.474732236495646 | 1.08858887903907E-8 | 0.00280630917527262 | 0.00972980877962454 | 0.46732263590517 | 11007.0641239407 | 22426.4186578027 | 29153.7668969926 | 20862.416559578665 | 1.62969685459921E7 | 1.53776908456905E7 | 4644794.12302626 | 1.2106484504902953E7 | 1608421.63729791 | 1232799.46655266 | 1507622.18059477 | 1449614.4281484466 | 244493.865771831 | 206768.885305398 | 181767.385360463 | 211010.04547923067 | 48104.5148614081 | 121500.029653831 | 119126.026959952 | 96243.5238250637 |
| Q61147 | Ceruloplasmin [OS=Mus musculus] | 175.43 | 36 | 33 | 380 | 33 | 1061 | 121.1 | cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular | other molecular function | 12870 | ENSMUSG00000003617 | Cp | mmu:12870; Q61147; Q6P5C8 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Iron uptake and transport; Metal ion SLC transporters | 1.65082956259427E-17 | 0.0286042496128814 | 0.232756100865398 | 0.470567140616547 | 0.114472406028442 | 0.902824569867946 | 0.217345018530886 | 0.830251457557488 | 174325.913751449 | 58856.3090021062 | 115033.849364799 | 116072.0240394514 | 9557281.19120236 | 1.04767827169696E7 | 8762702.67228452 | 9598922.193485493 | 5461844.00566682 | 4018732.98956624 | 4629071.77649001 | 4703216.257241024 | 4355240.25919752 | 3723693.63350954 | 2684226.57769155 | 3587720.1567995367 | 1720243.51649846 | 1992732.45731179 | 1556963.66647869 | 1756646.5467629798 | |
| Q3UQ28 | Peroxidasin homolog [OS=Mus musculus] | 173.636 | 35 | 39 | 366 | 39 | 1475 | 165 | cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes | extracellular matrix;ER/Golgi;other cell component | extracellular structural activity;other molecular function | 69675 | ENSMUSG00000020674 | Pxdn | A4FU83; E9QNQ9; mmu:69675; Q3UQ28 | Crosslinking of collagen fibrils | 0.121749369203589 | 0.199060935853007 | 0.481687712882875 | 0.64860195920101 | 0.414844709855988 | 0.680311384167738 | 0.622521206052951 | 0.910753558746772 | 41306.9360165718 | 84058.3874627107 | 31201.070658041 | 52188.79804577449 | 9910595.89492489 | 1.28240532958945E7 | 7690537.3381544 | 1.0141728842991263E7 | 3188445.14026578 | 3418561.86158515 | 3797799.58981602 | 3468268.863888983 | 6834484.53714744 | 5848987.74573488 | 4912888.48741006 | 5865453.59009746 | 743355.386480967 | 2642059.33003837 | 1858779.55214279 | 1748064.7562207088 | |
| Q61316 | Heat shock 70 kDa protein 4 [OS=Mus musculus] | 169.044 | 48 | 31 | 300 | 31 | 841 | 94.1 | protein metabolism;other metabolic processes | other cell component | other molecular function | Hspa4 | Q61316 | Regulation of HSF1-mediated heat shock response | 0.675982462193546 | 0.947627746595709 | 0.704651587991194 | 0.760498481134506 | 0.937908804051419 | 0.922660568001848 | 0.905946265571965 | 0.842404289073844 | 22434.4697799145 | 118934.685179003 | 13120.5332518918 | 51496.56273693644 | 3090247.7626811 | 3632683.19217962 | 4934376.07998548 | 3885769.0116153997 | 1752659.26658268 | 1094548.72984359 | 2299362.24833368 | 1715523.4149199834 | 6254897.5603188 | 4282912.67963475 | 3832568.37667092 | 4790126.20554149 | 1139246.15986255 | 2002609.64313824 | 1209098.21921722 | 1450318.0074060035 | |||
| Cont_P02533 | Keratin, type I cytoskeletal 14 OS=Homo sapiens OX=9606 GN=KRT14 PE=1 SV=4 | 164.831 | 58 | 26 | 684 | 9 | 472 | 51.5 | cell organization and biogenesis;other biological processes | plasma membrane;cytosol;cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 3861 | ENSG00000186847 | KRT14 | hsa:3861; P02533; Q14715; Q53XY3; Q9BUE3; Q9UBN2; Q9UBN3; Q9UCY4 | Corticotropin-releasing hormone signaling | Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin; Developmental Lineage of Mammary Gland Myoepithelial Cells; Type I hemidesmosome assembly | 0.821333803243143 | 0.880930298968675 | 0.666244110962191 | 0.887279041944908 | 0.735573385767802 | 0.728871118050286 | 0.645534074006669 | 1.76226512549596E-4 | 6033554.14310828 | 6671959.15781397 | 7782964.06135275 | 6829492.454091667 | 8837829.92566611 | 1.15627425945257E7 | 9278023.72116937 | 9892865.41378706 | 1.41062299354562E7 | 8950994.20838312 | 7841743.81261716 | 1.0299655985485494E7 | 1.15454726530467E7 | 7260451.91646668 | 9574113.2223773 | 9460012.597296894 | 2.05703168301172E7 | 1.34402077310531E7 | 5.39893889957522E7 | 2.9333304518974166E7 |
| P11499 | Heat shock protein HSP 90-beta [OS=Mus musculus] | 164.719 | 50 | 29 | 532 | 19 | 724 | 83.2 | cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component | enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function | 15516 | ENSMUSG00000023944 | Hsp90ab1 | mmu:15516; O89078; P11499; Q3UIQ7 | Focal adhesion: PI3K-Akt-mTOR signaling pathway | Neutrophil degranulation; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of actin dynamics for phagocytic cup formation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Attenuation phase; Estrogen-dependent gene expression; Sema3A PAK dependent Axon repulsion; Aryl hydrocarbon receptor signalling; DDX58/IFIH1-mediated induction of interferon-alpha/beta; HSF1 activation; RHOBTB2 GTPase cycle; The NLRP3 inflammasome | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.952333191127893 | 0.385192173946943 | 0.975071223710592 | 0.476079393565723 | 221410.585638305 | 129165.68527882 | 147525.692220339 | 166033.98771248801 | 3.34627647115336E7 | 3.61961534999558E7 | 2.61391308788083E7 | 3.193268303009924E7 | 9541203.16877468 | 9273367.56835581 | 1.36082703259873E7 | 1.0807613687705928E7 | 4.57710434253974E7 | 4.37708354854306E7 | 3.73056416942256E7 | 4.22825068683512E7 | 7437513.65495311 | 1.56244060515822E7 | 1.17622035416132E7 | 1.1608041082716169E7 |
| Q9JKF1 | Ras GTPase-activating-like protein IQGAP1 [OS=Mus musculus] | 163.926 | 28 | 36 | 250 | 36 | 1657 | 188.6 | cell organization and biogenesis;developmental processes;signal transduction;other biological processes | plasma membrane;other membranes;cytoskeleton;nucleus;other cell component | enzyme regulator activity;other molecular function | 29875 | ENSMUSG00000030536 | Iqgap1 | G3UW45; mmu:29875; Q9JKF1 | G13 signaling pathway; Regulation of actin cytoskeleton | RHO GTPases activate IQGAPs; Neutrophil degranulation; RAC1 GTPase cycle; RAC2 GTPase cycle; RHOA GTPase cycle; MAP2K and MAPK activation; RHOQ GTPase cycle; RHOC GTPase cycle; RHOU GTPase cycle; RHOV GTPase cycle; Nephrin family interactions | 0.930229675308081 | 0.794460986683881 | 0.787568130909409 | 0.991639536226218 | 0.830676695521175 | 0.941920360687835 | 0.777195460870953 | 0.924682711624237 | 49243.316732893 | 68725.418758499 | 58984.367745696 | 969026.209101501 | 1404075.03080168 | 833592.785314498 | 1068898.0084058929 | 204266.486982725 | 334218.990287697 | 455010.844725875 | 331165.4406654323 | 4213732.69874793 | 3933999.53801573 | 3238797.72524118 | 3795509.9873349466 | 503563.00444482 | 1468565.36197421 | 860307.289081776 | 944145.2185002686 | |
| P52480 | Pyruvate kinase PKM [OS=Mus musculus] | 163.393 | 62 | 27 | 442 | 27 | 531 | 57.8 | cell organization and biogenesis;other metabolic processes;other biological processes | cytosol;ER/Golgi;nucleus;other cell component | nucleic acid binding activity;kinase activity;other molecular function | 18746 | ENSMUSG00000032294 | Pkm | mmu:18746; P52480; Q3TBV8; Q3TBW5; Q3TC59; Q3U1X3; Q3U5P6; Q4VC20; Q64484; Q91YI8; Q9CWB1 | Glycolysis and gluconeogenesis; Purine metabolism | Neutrophil degranulation; Pyruvate metabolism; Glycolysis; Regulation of pyruvate metabolism | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.938859506774495 | 0.972868731003358 | 0.958705855138011 | 0.959522188921769 | 312569.127047718 | 79336.1029165598 | 280190.614862653 | 224031.9482756436 | 2.13357824001936E7 | 1.96436562290884E7 | 9081648.29120601 | 1.6687028973496003E7 | 1.01259485831113E7 | 9467201.29798786 | 1.55257573035923E7 | 1.1706302394897154E7 | 3.31547939620584E7 | 3.43565739025104E7 | 2.75852274417617E7 | 3.1698865102110166E7 | 7722776.69094361 | 1.86748082798887E7 | 1.43901632993649E7 | 1.3595916090065738E7 |
| P63017 | Heat shock cognate 71 kDa protein [OS=Mus musculus] | 161.557 | 53 | 28 | 572 | 23 | 646 | 70.8 | cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component | signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function | 15481 | ENSMUSG00000015656 | Hspa8 | mmu:15481; P08109; P12225; P63017; Q3U6R0; Q3U764; Q3U7D7; Q3U7E2; Q3U9B4; Q3U9G0; Q3UGM0; Q5FWJ6; Q62373; Q62374; Q62375; Q6NZD0 | Mapk signaling pathway; Exercise-induced circadian regulation | Neutrophil degranulation; mRNA Splicing - Major Pathway; Regulation of HSF1-mediated heat shock response; PKR-mediated signaling; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis; Attenuation phase; Lysosome Vesicle Biogenesis; GABA synthesis, release, reuptake and degradation; AUF1 (hnRNP D0) binds and destabilizes mRNA; Protein methylation | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.987939278265184 | 0.953011140807089 | 0.709593139419252 | 0.587315224195015 | 247063.168316828 | 221267.865667273 | 228333.997143376 | 232221.67704249235 | 2.34302361722569E7 | 1.91610816116977E7 | 2.44529780700925E7 | 2.2348098618015703E7 | 1.52458610795295E7 | 1.21057626921531E7 | 1.98188188374949E7 | 1.5723480869725833E7 | 4.35786305197153E7 | 3.523488629513E7 | 2.44125225303247E7 | 3.440867978172333E7 | 9679200.3009757 | 1.32405397257932E7 | 1.30838270231471E7 | 1.2001189016638666E7 |
| Q9JHU4 | Cytoplasmic dynein 1 heavy chain 1 [OS=Mus musculus] | 161.009 | 14 | 55 | 258 | 55 | 4644 | 531.7 | cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes | cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 13424 | ENSMUSG00000018707 | Dync1h1 | E9QM71; mmu:13424; Q9JHU4 | MHC class II antigen presentation; Neutrophil degranulation; Separation of Sister Chromatids; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; COPI-mediated anterograde transport; Recruitment of NuMA to mitotic centrosomes; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-independent Golgi-to-ER retrograde traffic; Aggrephagy; Anchoring of the basal body to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; AURKA Activation by TPX2 | 0.591873375996003 | 0.826895204418257 | 0.758743075163871 | 0.936818656936794 | 0.771389136401717 | 0.987352798667733 | 0.695927216301667 | 0.953305976192702 | 224060.75101347 | 288932.991027563 | 370866.333925136 | 294620.0253220563 | 1035717.43113769 | 1898525.78207622 | 892363.147243056 | 1275535.4534856554 | 298543.620628635 | 395801.785314415 | 659710.172961205 | 451351.8596347517 | 5741364.17159479 | 5412980.23144293 | 4332188.15134028 | 5162177.518126 | 1219184.02821873 | 1626625.47525789 | 1541170.38578568 | 1462326.6297541 | |
| Q99K41 | EMILIN-1 [OS=Mus musculus] | 157.011 | 31 | 21 | 244 | 21 | 1017 | 107.5 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 100952 | ENSMUSG00000029163 | Emilin1 | mmu:100952; Q99K41 | Molecules associated with elastic fibres | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.169879542413978 | 0.64186124184599 | 0.0921665663508908 | 0.491906845171331 | 6287128.66260445 | 6034831.78772075 | 4173278.84836641 | 5498413.09956387 | 1744058.35010072 | 1513530.29654839 | 1757558.94039384 | 1671715.86234765 | 2698540.13579468 | 2559754.7470142 | 1836473.80243277 | 2364922.89508055 | 286714.652107864 | 495091.120602366 | 371444.218276851 | 384416.66366236034 | |||||
| Q61879 | Myosin-10 [OS=Mus musculus] | 146 | 19 | 31 | 236 | 20 | 1976 | 228.9 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;nucleic acid binding activity;other molecular function | 77579 | ENSMUSG00000020900 | Myh10 | mmu:77579; Q5SV63; Q61879 | Regulation of actin cytoskeleton | RHO GTPases activate PAKs | 0.705689538076567 | 0.506231596289679 | 0.676239752697828 | 0.933545599871938 | 0.996007724449986 | 0.990096171400123 | 0.953146340313072 | 0.921444667457376 | 132922.802732814 | 81410.1821075416 | 155803.703539863 | 123378.89612673952 | 578601.376274227 | 569525.366217458 | 228469.06472958 | 458865.269073755 | 249877.75631 | 195698.454667987 | 352494.602688902 | 266023.60455562966 | 1222751.03080206 | 1020719.46631895 | 1025108.65415173 | 1089526.38375758 | 489393.525760184 | 539451.948957579 | 659882.564109888 | 562909.3462758837 |
| Cont_P00761 | Trypsin OS=Sus scrofa OX=9823 PE=1 SV=1 | 143.502 | 62 | 11 | 3859 | 10 | 231 | 24.4 | protein metabolism;other biological processes | non-structural extracellular | other molecular function | 0.254996071775817 | 0.172153475402034 | 0.357784551188889 | 0.34040294575649 | 0.822223648478518 | 0.740968241512781 | 0.960577895552113 | 0.148582186670595 | 5.17896971017178E9 | 5.13317471139103E9 | 7.27761160813741E9 | 5.863252009900073E9 | 2.70973552724487E9 | 1.73168232498425E9 | 2.0962236592694E9 | 2.1792138371661735E9 | 3.08554430734093E9 | 3.85764460784296E9 | 3.06099934235171E9 | 3.334729419178533E9 | 1.42194297351806E9 | 1.8379662886425E9 | 3.81973460995747E9 | 2.35988129070601E9 | 5.3849654871275E9 | 2.81761370832162E9 | 5.23567407489624E9 | 4.479417756781787E9 | ||||||
| P20029 | Endoplasmic reticulum chaperone BiP [OS=Mus musculus] | 142.966 | 48 | 25 | 434 | 23 | 655 | 72.4 | protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component | enzyme regulator activity;translation activity;other molecular function | 14828 | ENSMUSG00000026864 | Hspa5 | mmu:14828; O35642; P20029; Q3UFF2; Q61630 | Mapk signaling pathway | Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Regulation of HSF1-mediated heat shock response | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.916283277860523 | 0.769590657123576 | 0.985707795620743 | 0.888702680095366 | 7850142.93480902 | 7648809.53150357 | 9169945.31743656 | 8222965.927916382 | 7535475.80605118 | 5802650.52918468 | 8839942.11003441 | 7392689.481756757 | 1.89485602512479E7 | 1.6006905998567E7 | 1.24118184289709E7 | 1.57890948929286E7 | 7216046.0503345 | 9459779.49149077 | 8533209.24248049 | 8403011.594768586 | ||||
| Cont_P13647 | Keratin, type II cytoskeletal 5 OS=Homo sapiens OX=9606 GN=KRT5 PE=1 SV=3 | 142.395 | 51 | 34 | 500 | 20 | 590 | 62.3 | cell organization and biogenesis;other biological processes | cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;cytoskeletal activity;other molecular function | 3852 | ENSG00000186081 | KRT5 | hsa:3852; P13647; Q6PI71; Q6UBJ0; Q8TA91 | Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin; Developmental Lineage of Mammary Stem Cells; Developmental Lineage of Mammary Gland Myoepithelial Cells; Type I hemidesmosome assembly | 0.786915923361782 | 0.847457711018997 | 0.707170943024881 | 0.746833150482801 | 0.873755746039336 | 0.714156118974909 | 0.2733017775894 | 2.49132633766938E-5 | 5120503.46953844 | 5171426.92187225 | 6553368.21772984 | 5615099.536380176 | 9669299.63907403 | 1.1127930529353E7 | 9127716.50969809 | 9974982.226041706 | 9513581.76230213 | 7584977.17814252 | 6506980.60696686 | 7868513.182470503 | 1.59683716443188E7 | 1.28154121523541E7 | 1.32126695164861E7 | 1.3998817771053001E7 | 1.8678004759752E7 | 1.36191738010446E7 | 5.39600661696836E7 | 2.8752414910160065E7 | |
| Cont_P08779 | Keratin, type I cytoskeletal 16 OS=Homo sapiens OX=9606 GN=KRT16 PE=1 SV=4 | 140.751 | 54 | 25 | 569 | 12 | 473 | 51.2 | cell organization and biogenesis;stress response;other biological processes | plasma membrane;cytosol;cytoskeleton | cytoskeletal activity | 3868 | ENSG00000186832 | KRT16 | A8K488; hsa:3868; P08779; P30654; Q16402; Q9UBG8 | Vitamin D receptor pathway | Formation of the cornified envelope | 0.941324060398065 | 0.961351301268194 | 0.761460393544015 | 0.887279041944908 | 0.82543231800733 | 0.493923182294169 | 0.895302208460818 | 3.1065941501805E-4 | 1047544.82178002 | 1389728.97312405 | 1389730.63830375 | 1275668.1444026066 | 1501449.09449526 | 2307427.01338473 | 2939547.44501319 | 2249474.51763106 | 7196685.12946156 | 1715910.61220057 | 2812173.28112121 | 3908256.3409277797 | 4331979.12309994 | 1639569.64130669 | 1737373.70058763 | 2569640.8216647534 | 4434008.92515372 | 2223613.02167429 | 9547147.41410007 | 5401589.786976026 |
| Cont_P02465 | Collagen alpha-2(I) chain OS=Bos taurus OX=9913 GN=COL1A2 PE=1 SV=2 | 139.99 | 18 | 19 | 445 | 3 | 1364 | 129 | non-structural extracellular;extracellular matrix | extracellular structural activity;other molecular function | 282188 | ENSBTAG00000013472 | COL1A2 | A6QP13; bta:282188; O62649; P02465 | Inflammatory response pathway; Focal adhesion | Fibronectin matrix formation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Collagen degradation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; Collagen chain trimerization; GPVI-mediated activation cascade; Platelet Aggregation (Plug Formation); Platelet Adhesion to exposed collagen; GP1b-IX-V activation signalling | 0.483779141493222 | 0.876027096029978 | 0.421836754550416 | 0.488872343346086 | 0.731850662833984 | 0.076245756040016 | 0.549852418071669 | 0.432748651973214 | 80849.8235508145 | 93725.5578519836 | 35755.9745173747 | 70110.45197339094 | 170240.553800628 | 153570.468872413 | 167384.810476394 | 163731.944383145 | 78292.6458688874 | 70345.2867467554 | 108688.239366299 | 85775.39066064726 | 65032.7123193958 | 48396.6073357386 | 51482.0177898574 | 54970.44581499727 | 51011.1923790395 | 62191.0072542807 | 32903.9376967684 | 48702.045776696206 | |
| Cont_P12763 | Alpha-2-HS-glycoprotein OS=Bos taurus OX=9913 GN=AHSG PE=1 SV=2 | 132.772 | 50 | 16 | 1191 | 16 | 359 | 38.4 | stress response;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component | enzyme regulator activity | 280988 | AHSG | A6QLF7; bta:280988; P12763 | Neutrophil degranulation; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 0.573667790345329 | 0.793013134473823 | 0.624272910267193 | 0.36488675645736 | 0.946568086066385 | 0.268930374946741 | 0.335956814949331 | 0.913214993335179 | 6.75081036645858E8 | 9.56771805796805E8 | 4.32862555462728E8 | 6.882384659684638E8 | 6.04790296716478E8 | 6.42824998486085E8 | 6.76887564991134E8 | 6.41500953397899E8 | 8.54466282868744E8 | 8.4303805016043E8 | 9.16216503216691E8 | 8.712402787486216E8 | 7.41908408260606E8 | 7.48114705273509E8 | 6.29285280642112E8 | 7.064361313920757E8 | 3.42283489676807E8 | 6.64083343401506E8 | 3.25834950231514E8 | 4.440672611032756E8 | ||
| P07901 | Heat shock protein HSP 90-alpha [OS=Mus musculus] | 132.382 | 43 | 25 | 402 | 16 | 733 | 84.7 | cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component | signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function | 15519 | ENSMUSG00000021270 | Hsp90aa1 | mmu:15519; P07901 | EBV LMP1 signaling; Focal adhesion: PI3K-Akt-mTOR signaling pathway; IL-6 signaling pathway; IL-2 signaling pathway | Regulation of necroptotic cell death; Recruitment of NuMA to mitotic centrosomes; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of actin dynamics for phagocytic cup formation; Neutrophil degranulation; Downregulation of ERBB2 signaling; Anchoring of the basal body to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; AURKA Activation by TPX2; Extra-nuclear estrogen signaling; Attenuation phase; Estrogen-dependent gene expression; Sema3A PAK dependent Axon repulsion; VEGFR2 mediated vascular permeability; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation; DDX58/IFIH1-mediated induction of interferon-alpha/beta; eNOS activation; HSF1 activation; RHOBTB2 GTPase cycle; Drug-mediated inhibition of ERBB2 signaling | 1.65082956259427E-17 | 0.508730894200713 | 1.50457038391225E-17 | 0.251664970734015 | 0.974827674952665 | 0.788764875934969 | 0.968364585136618 | 0.745600589176001 | 51071.3130902855 | 169244.190500369 | 193833.457176882 | 138049.65358917884 | 3826029.08230807 | 4600695.96516161 | 3479662.10980986 | 3968795.71909318 | 1533159.7098775 | 1700635.66665037 | 1768278.53880507 | 1667357.9717776468 | 6471421.59388824 | 6122550.53993506 | 5450079.38924241 | 6014683.841021903 | 900341.190737514 | 2215799.13247972 | 1704183.40484156 | 1606774.576019598 |
| Q02819 | Nucleobindin-1 [OS=Mus musculus] | 131.152 | 51 | 21 | 299 | 21 | 459 | 53.4 | signal transduction | non-structural extracellular;other membranes;ER/Golgi | enzyme regulator activity;nucleic acid binding activity;other molecular function | 18220 | ENSMUSG00000030824 | Nucb1 | mmu:18220; Q02819; Q3TU42; Q9CWA1; Q9D8J4; Q9DBL3 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 0.130903496983571 | 0.0679830640731695 | 0.340647566778883 | 0.397987186613988 | 0.958122559708965 | 41072.7931792495 | 20198.6046706008 | 30635.69892492515 | 1.70846710933602E7 | 1.97547416617741E7 | 2.08807433533847E7 | 1.9240052036173E7 | 5757191.6972993 | 4828078.95450858 | 5895038.38978249 | 5493436.34719679 | 7136546.74332753 | 7387752.88718417 | 5120327.81590923 | 6548209.148806977 | 1130733.36645935 | 3369667.63744922 | 2637872.59598673 | 2379424.5332984333 | ||
| Q91V92 | ATP-citrate synthase [OS=Mus musculus] | 129.973 | 32 | 28 | 237 | 28 | 1091 | 119.7 | other metabolic processes | cytosol | other molecular function | 104112 | ENSMUSG00000020917 | Acly | mmu:104112; Q91V92 | Fatty acid biosynthesis | Neutrophil degranulation; Fatty acyl-CoA biosynthesis | 0.230775890814232 | 0.371468864113786 | 0.437429424171984 | 0.509570119936397 | 0.626059420687734 | 0.98558531112136 | 0.643183834410259 | 0.922580167429744 | 8856.99380706579 | 32765.2400642807 | 40990.0091117865 | 27537.414327710998 | 2382723.31982566 | 2481678.51703659 | 2154876.39410613 | 2339759.4103227933 | 1256305.5375454 | 885993.369046538 | 1688459.92743218 | 1276919.6113413726 | 2057502.05407172 | 1815562.79058184 | 1460220.9588277 | 1777761.9344937534 | 534991.757912276 | 802971.776166877 | 594587.914542531 | 644183.8162072281 |
| A2ASQ1 | Agrin [OS=Mus musculus] | 128.989 | 18 | 26 | 227 | 26 | 1950 | 207.4 | cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cell component | signal transduction activity or receptor binding;other molecular function | 11603 | ENSMUSG00000041936 | Agrn | A2ASP9; A2ASQ0; A2ASQ1; B2RWU1 | Primary focal segmental glomerulosclerosis (FSGS) | ECM proteoglycans; Retinoid metabolism and transport; Glycosaminoglycan-protein linkage region biosynthesis; HS-GAG biosynthesis; HS-GAG degradation; Formation of the dystrophin-glycoprotein complex (DGC) | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.460727828548759 | 0.972791368602389 | 0.686318824668434 | 0.846971399004193 | 2612028.52511147 | 3116500.52541199 | 3328171.1398056 | 3018900.06344302 | 1818519.74579979 | 1551006.46226864 | 1715477.48863677 | 1695001.2322350666 | 2313945.16119856 | 2044906.61336417 | 1778324.63596447 | 2045725.4701757336 | 632566.873707257 | 1496109.18442141 | 957812.214242183 | 1028829.4241236168 | ||||
| Q61508 | Extracellular matrix protein 1 [OS=Mus musculus] | 127.379 | 45 | 18 | 358 | 18 | 559 | 62.8 | stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular | signal transduction activity or receptor binding;other molecular function | 13601 | ENSMUSG00000028108 | Ecm1 | mmu:13601; Q3U5Q5; Q61508 | Platelet degranulation | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 0.121600547823456 | 2.27890527565265E-4 | 0.795351011232032 | 1.51989274634622E-7 | 0.592370654746194 | 110159.96586707 | 68619.5270607555 | 45654.6843175291 | 74811.39241511819 | 5.6443097497098E7 | 7.11751205740166E7 | 5.82782830048746E7 | 6.196550035866306E7 | 5.1935854689884E7 | 4.50204039942893E7 | 5.70225374161979E7 | 5.132626536679041E7 | 1.27540105597053E7 | 1.25514774649527E7 | 8690203.83604475 | 1.1331897286900917E7 | 2192350.97546663 | 4663417.73981907 | 3690111.31703252 | 3515293.344106073 | |
| Cont_P04259 | Keratin, type II cytoskeletal 6B OS=Homo sapiens OX=9606 GN=KRT6B PE=1 SV=5 | 126.901 | 47 | 30 | 442 | 4 | 564 | 60 | cell organization and biogenesis;other biological processes | cytosol;cytoskeleton | bone, tooth or skin structural activity;cytoskeletal activity | 3854 | ENSG00000185479 | KRT6B | hsa:3854; P04259; P48669 | Formation of the cornified envelope | 0.857251372850113 | 0.868132360832926 | 0.758743075163871 | 0.801271130817871 | 0.854305439376382 | 0.340133476321195 | 0.937453377971347 | 0.00123883404563536 | 267279.779286483 | 355493.362381868 | 274137.281616349 | 298970.1410949 | 326989.588402741 | 585438.697100962 | 617622.938974811 | 510017.07482617133 | 2390973.53573307 | 430931.486741926 | 646270.614315847 | 1156058.5455969477 | 1869779.42318807 | 346417.77494154 | 348508.009299423 | 854901.7358096777 | 1155463.67620058 | 538093.594898596 | 1653754.7898307 | 1115770.6869766254 | |
| P17182 | Alpha-enolase [OS=Mus musculus] | 126.804 | 60 | 19 | 244 | 16 | 434 | 47.1 | other metabolic processes;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;other cell component | nucleic acid binding activity;other molecular function | 13806; 433182 | ENSMUSG00000059040; ENSMUSG00000063524 | Eno1 | mmu:13806; mmu:433182; P17182; Q99KT7; Q9DCY7 | Glycolysis and gluconeogenesis | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.720832939248489 | 0.789540446904924 | 0.858218537342417 | 0.989544231571828 | 31098.019126098 | 70318.9502605952 | 40658.6319347469 | 47358.53377381337 | 1.28655809626545E7 | 1.34726279447959E7 | 7101469.5445256 | 1.1146559483992001E7 | 9089751.86845938 | 7552189.93174957 | 1.17772011823713E7 | 9473047.660860082 | 3.50544676757808E7 | 2.99447661492486E7 | 2.18255690502528E7 | 2.89416009584274E7 | 1.11532480577619E7 | 1.75489228796712E7 | 1.30151947674988E7 | 1.3905788568310633E7 | |
| P08113 | Endoplasmin [OS=Mus musculus] | 126.346 | 39 | 26 | 329 | 25 | 802 | 92.4 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cell component | signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function | 22027 | ENSMUSG00000020048 | Hsp90b1 | mmu:22027; P08113; P11427 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Hypoxia-dependent self-renewal of myoblasts | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Scavenging by Class A Receptors; Trafficking and processing of endosomal TLR; Interleukin-4 and Interleukin-13 signaling | 0.107476768049312 | 0.0104456807471941 | 1.50457038391225E-17 | 0.205304099107124 | 0.854305439376382 | 0.840785133352029 | 0.866766165039268 | 0.896996950298791 | 75656.6139115948 | 52183.5314261123 | 29905.9702816436 | 52582.03853978356 | 5932785.14172209 | 5786569.94317903 | 3299962.37110113 | 5006439.15200075 | 3817668.17887426 | 3366255.7650389 | 4907428.60350699 | 4030450.84914005 | 1.47606948013545E7 | 1.21020755462977E7 | 1.0441016038914E7 | 1.2434595462188734E7 | 3792376.91369813 | 7854793.82920015 | 6464144.86133097 | 6037105.20140975 |
| P58252 | Elongation factor 2 [OS=Mus musculus] | 126.048 | 37 | 31 | 378 | 30 | 858 | 95.3 | cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;translational apparatus;other cell component | cytoskeletal activity;translation activity;nucleic acid binding activity;other molecular function | 13629 | ENSMUSG00000034994 | Eef2 | mmu:13629; P58252; Q544E4 | Translation factors | Neutrophil degranulation; Protein methylation; Peptide chain elongation; Synthesis of diphthamide-EEF2 | 0.299809054080284 | 0.188334321166369 | 0.471929633209224 | 0.84258396038376 | 0.922179983282929 | 0.97504218639442 | 0.866546043492515 | 0.950878070645738 | 275529.241689771 | 247076.7728808 | 166294.142173825 | 229633.38558146535 | 1.22498155967913E7 | 1.26488626480754E7 | 6800245.14611723 | 1.0566307796994643E7 | 5717562.35282925 | 5172569.64432748 | 8352282.82529915 | 6414138.274151959 | 1.55667000517401E7 | 1.33925688878402E7 | 1.02378508629272E7 | 1.3065706600835832E7 | 2972661.18095993 | 6421886.97759523 | 5184391.52691505 | 4859646.5618234025 |
| Cont_P02538 | Keratin, type II cytoskeletal 6A OS=Homo sapiens OX=9606 GN=KRT6A PE=1 SV=3 | 123.757 | 47 | 30 | 454 | 3 | 564 | 60 | cell organization and biogenesis;stress response;other biological processes | cytosol;cytoskeleton | bone, tooth or skin structural activity;cytoskeletal activity | 3853 | ENSG00000205420 | KRT6A | A4QPC1; hsa:3853; P02538; P48667; Q08AR4; Q6NT67; Q96CL4 | Ectoderm differentiation; Ectoderm differentiation; Pancreatic cancer subtypes | Formation of the cornified envelope | 0.892533464536408 | 0.964633336683333 | 0.745886066139481 | 0.84258396038376 | 0.792564971776066 | 0.574739141583974 | 0.709593139419252 | 5.66461038960431E-4 | 2017098.82314832 | 2171650.09464557 | 2359880.73116726 | 2182876.549653717 | 2825309.68904382 | 4320098.03084773 | 4192074.59940388 | 3779160.7730984767 | 8075888.41129776 | 2685265.07688442 | 3594101.84504227 | 4785085.111074816 | 5878699.8667026 | 3215829.01184206 | 2854010.96069105 | 3982846.61307857 | 8158147.16608847 | 4198498.19802621 | 1.30998597349634E7 | 8485501.699692694 |
| P97298 | Pigment epithelium-derived factor [OS=Mus musculus] | 123.502 | 47 | 16 | 346 | 12 | 417 | 46.2 | cell cycle OR cell proliferation;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | enzyme regulator activity | 20317 | ENSMUSG00000000753 | Serpinf1 | mmu:20317; O70629; O88691; P97298 | 1.65082956259427E-17 | 0.227296093012204 | 0.434748506750565 | 0.770205086382264 | 0.00901230529014985 | 0.174886032348437 | 0.300753028734261 | 0.891044455497809 | 554016.1710638 | 470705.490372182 | 363015.858993357 | 462579.17347644636 | 5.24905837082578E7 | 7.20656975211191E7 | 8.90978835263609E7 | 7.121805491857927E7 | 1.55195541438312E7 | 1.33807646088142E7 | 1.504676823338E7 | 1.46490289953418E7 | 1.63245792137601E7 | 1.5700230598517E7 | 1.5246806329463E7 | 1.5757205380580032E7 | 3869051.7420588 | 8996988.40278734 | 4897006.93274029 | 5921015.69252881 | ||
| Q70E20 | Sushi, nidogen and EGF-like domain-containing protein 1 [OS=Mus musculus] | 122.942 | 19 | 22 | 287 | 22 | 1403 | 151.5 | cell adhesion | non-structural extracellular;extracellular matrix | other molecular function | 208777 | Sned1 | A6H6I3; mmu:208777; Q70E20; Q810H2; Q8BMD9 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.889058672589993 | 0.869908412860824 | 0.817293288705596 | 0.880760468933162 | 62940.5062355012 | 25184.2741656831 | 25459.8187779288 | 37861.533059704365 | 7879183.70581794 | 8304827.25748066 | 2617617.70526214 | 6267209.5561869135 | 3110990.0320528 | 3263544.92621848 | 3507274.08693078 | 3293936.3484006864 | 1.72480350493842E7 | 1.48489121993504E7 | 1.05732378776404E7 | 1.4223395042125002E7 | 2537287.1447922 | 7075122.99473268 | 5373074.41423662 | 4995161.517920501 | |||
| P13020 | Gelsolin [OS=Mus musculus] | 122.934 | 35 | 22 | 377 | 9 | 780 | 85.9 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 227753 | ENSMUSG00000026879 | Gsn | mmu:227753; P13020; Q3UPB1; Q8R590 | Regulation of actin cytoskeleton | Neutrophil degranulation; Caspase-mediated cleavage of cytoskeletal proteins | 0.440427841758307 | 0.396306424610341 | 0.186266168629733 | 0.379422692457324 | 0.65414435708462 | 0.994546642862744 | 0.709593139419252 | 0.793590033024783 | 1154075.61374729 | 1486973.5078743 | 778278.604931373 | 1139775.9088509877 | 1.0611315000974E7 | 9755419.92114226 | 9110194.21443976 | 9825643.045518672 | 6039243.17546894 | 5549542.61366164 | 7725308.54354706 | 6438031.44422588 | 3.63344365935893E7 | 2.77403609084757E7 | 2.33574049877416E7 | 2.9144067496602204E7 | 8417203.0170929 | 1.43392014575414E7 | 1.03453705657478E7 | 1.1033925013460701E7 |
| Q61398 | Procollagen C-endopeptidase enhancer 1 [OS=Mus musculus] | 120.4 | 40 | 14 | 323 | 14 | 468 | 50.1 | protein metabolism;other biological processes | enzyme regulator activity;other molecular function | 18542 | ENSMUSG00000029718 | Pcolce | mmu:18542; O35113; Q61398 | mRNA processing | Collagen biosynthesis and modifying enzymes; Crosslinking of collagen fibrils | 1.65082956259427E-17 | 1.8644578313253E-17 | 0.151224536345852 | 0.288320039261486 | 0.133905327763598 | 0.789540446904924 | 0.0895861566882082 | 0.711902858921665 | 55825.2363051742 | 84655.3590880939 | 113029.200120433 | 84503.2651712337 | 3.10244208090572E7 | 2.97623271730106E7 | 2.79757713270171E7 | 2.958750643636163E7 | 2.72578314339105E7 | 2.28908828526637E7 | 2.54654481194513E7 | 2.52047208020085E7 | 1.54882233602667E7 | 1.24902767859117E7 | 9636426.2851997 | 1.2538308810459368E7 | 5125325.32901055 | 9907837.52014591 | 7984547.74798259 | 7672570.19904635 | |
| P26039 | Talin-1 [OS=Mus musculus] | 118.226 | 15 | 30 | 153 | 30 | 2541 | 269.7 | cell adhesion;cell organization and biogenesis;signal transduction | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;other molecular function | 21894 | ENSMUSG00000028465 | Tln1 | A2AIM8; mmu:21894; P26039; Q8VEF0 | Primary focal segmental glomerulosclerosis (FSGS); Integrin-mediated cell adhesion; Focal adhesion | Platelet degranulation ; MAP2K and MAPK activation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; Smooth Muscle Contraction; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 0.958262397335385 | 0.994542145304377 | 0.680632778351053 | 0.738983404380581 | 0.850917681937748 | 0.783910800136359 | 0.87222702623065 | 0.535066779633529 | 137218.697336797 | 64798.4580467583 | 241653.653741064 | 147890.2697082064 | 580168.664793601 | 803244.58151111 | 320387.746187394 | 567933.664164035 | 118081.406885094 | 124079.798936285 | 255551.526824265 | 165904.24421521465 | 2877993.84785898 | 2114900.66089323 | 1881659.61273992 | 2291518.0404973766 | 240671.449108311 | 385063.079961369 | 234819.255172709 | 286851.2614141297 |
| Q8BPB5 | EGF-containing fibulin-like extracellular matrix protein 1 [OS=Mus musculus] | 117.738 | 49 | 15 | 220 | 15 | 493 | 54.9 | protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes | extracellular matrix | signal transduction activity or receptor binding;kinase activity;other molecular function | 216616 | ENSMUSG00000020467 | Efemp1 | mmu:216616; Q6Y3N6; Q8BPB5 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 0.376780684027729 | 0.278244203695445 | 0.983440558239231 | 0.145805028390539 | 0.982581944728745 | 15298.8221438323 | 19141.8575027524 | 55545.7753728227 | 29995.485006469138 | 7090020.68988726 | 8805500.10345141 | 5126350.07183034 | 7007290.288389671 | 4435222.67421531 | 4392813.74676133 | 4496081.41897935 | 4441372.613318663 | 4016966.57007158 | 3984703.05528875 | 2817881.79753384 | 3606517.1409647237 | 682456.349264741 | 1966499.77195883 | 1462163.85427198 | 1370373.3251651835 | ||
| P09411 | Phosphoglycerate kinase 1 [OS=Mus musculus] | 116.462 | 57 | 18 | 287 | 18 | 417 | 44.5 | protein metabolism;other metabolic processes;stress response;other biological processes | non-structural extracellular;other membranes;cytosol;mitochondrion;other cell component | kinase activity;other molecular function | 18655 | ENSMUSG00000062070 | Pgk1 | mmu:18655; P09411; Q3TPE6; Q3UKV8; Q5XJE7 | Glycolysis and gluconeogenesis | Gluconeogenesis; Glycolysis | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.465126095372736 | 0.766862952867809 | 0.820281310709571 | 0.891044455497809 | 78089.4641074341 | 38741.0917691314 | 23421.0514741904 | 46750.53578358531 | 4316274.39280249 | 5023293.68471847 | 1442874.888393 | 3594147.655304653 | 2829873.33459098 | 2934698.045784 | 3868274.47312523 | 3210948.6178334034 | 1.65254946701665E7 | 1.56270051770472E7 | 1.22346365889796E7 | 1.4795712145397767E7 | 2315853.03926933 | 6654180.61411261 | 4530199.20599689 | 4500077.619792943 |
| P27773 | Protein disulfide-isomerase A3 [OS=Mus musculus] | 115.891 | 55 | 23 | 291 | 23 | 505 | 56.6 | cell adhesion;cell organization and biogenesis;stress response;signal transduction;other biological processes | non-structural extracellular;other membranes;ER/Golgi;other cell component | nucleic acid binding activity;other molecular function | 14827 | ENSMUSG00000027248 | Pdia3 | mmu:14827; P27773; Q3TEI9; Q3TIL2; Q3UZK8; Q8C2F4; Q99LF6 | ER-Phagosome pathway; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Calnexin/calreticulin cycle | 0.9135584231482 | 0.736536116100563 | 0.498293621965442 | 0.874168055361729 | 0.850917681937748 | 0.862063111456553 | 0.881496352314601 | 0.939046770372612 | 206281.038958907 | 253939.7116523 | 128510.108086966 | 196243.61956605766 | 6669793.66068216 | 7133803.24141356 | 5637352.69437344 | 6480316.532156386 | 5319375.96186612 | 3844376.07822282 | 6321729.00885173 | 5161827.016313557 | 1.83298906806341E7 | 1.50101054148645E7 | 1.26051366299531E7 | 1.5315044241817234E7 | 6059857.55300524 | 8984695.03809976 | 6670485.36185494 | 7238345.98431998 | |
| P10107 | Annexin A1 [OS=Mus musculus] | 115.566 | 64 | 18 | 270 | 18 | 346 | 38.7 | cell organization and biogenesis;stress response;transport;signal transduction;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component | enzyme regulator activity;other molecular function | 16952 | ENSMUSG00000024659 | Anxa1 | mmu:16952; P10107 | Spinal cord injury; Prostaglandin synthesis and regulation | G alpha (q) signalling events; G alpha (i) signalling events; Formyl peptide receptors bind formyl peptides and many other ligands | 1.65082956259427E-17 | 0.105053536950499 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.954328834404239 | 0.401885831342676 | 0.529099828181544 | 0.924766494197286 | 13280.9290610842 | 9160.53166722029 | 4508.77124840677 | 8983.410658903753 | 5251880.61554565 | 6740833.31198439 | 6058745.6526555 | 6017153.19339518 | 1560362.01883491 | 1521121.84391776 | 1946127.08618424 | 1675870.316312303 | 1.11990207127477E7 | 1.0990927807692E7 | 1.0321301103113E7 | 1.08370832078509E7 | 3223846.7434476 | 4805492.80063037 | 4605609.45936174 | 4211649.667813237 |
| Cont_Q2KJF1 | Alpha-1B-glycoprotein OS=Bos taurus OX=9913 GN=A1BG PE=1 SV=1 | 115.502 | 48 | 14 | 224 | 14 | 503 | 53.5 | signal transduction | non-structural extracellular;plasma membrane;other membranes | 518955 | A1BG | bta:518955; Q2KJF1 | Platelet degranulation ; Neutrophil degranulation | 0.635218461842139 | 0.655487072215252 | 0.641514600397631 | 0.360991986803736 | 0.932231143665149 | 0.696358249006924 | 0.601376052147163 | 0.891044455497809 | 1.12339445909494E7 | 1.09217008752481E7 | 5999938.28834399 | 9385194.584847162 | 7597724.26810103 | 8696294.29830821 | 1.02832125493257E7 | 8859077.038578315 | 1.08372253099689E7 | 9914324.88654618 | 8710997.51604168 | 9820849.23751892 | 1.11963323092602E7 | 9450705.94975847 | 1.03053408353504E7 | 1.0317459698123023E7 | 5535891.07899516 | 9467766.08082133 | 5283853.74244175 | 6762503.63408608 | |||
| Cont_Q3MHN5 | Vitamin D-binding protein OS=Bos taurus OX=9913 GN=GC PE=2 SV=1 | 113.599 | 55 | 20 | 319 | 20 | 474 | 53.3 | other metabolic processes;transport | non-structural extracellular;other cell component | transporter activity;cytoskeletal activity;other molecular function | 530076 | GC | bta:530076; Q3MHN5 | 0.549057967251154 | 0.804331105646976 | 0.579435037816218 | 0.479472599858427 | 0.946173787415917 | 0.139718417146003 | 0.570795727084329 | 0.421365656927814 | 1.55879441314789E7 | 1.53074066841615E7 | 7458694.29508707 | 1.2784681703575822E7 | 1.04365108192777E7 | 1.20620475306269E7 | 8309099.82300618 | 1.026921939097026E7 | 1.67215053413279E7 | 1.54231806136738E7 | 1.57780518794517E7 | 1.5974245944817802E7 | 1.6556516146824E7 | 1.52311500265876E7 | 1.20681229464E7 | 1.4618596373270534E7 | 9478628.98672491 | 1.47438110125204E7 | 8133055.93664235 | 1.0785165311962552E7 | |||
| P17742 | Peptidyl-prolyl cis-trans isomerase A [OS=Mus musculus] | 113.527 | 60 | 9 | 369 | 9 | 164 | 18 | cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes | non-structural extracellular;cytosol;nucleus;other cell component | signal transduction activity or receptor binding;other molecular function | 268373 | ENSMUSG00000071866 | Ppia | mmu:268373; P17742; Q9CWJ5; Q9R137 | Neutrophil degranulation; Basigin interactions | 0.100219677394751 | 0.099382125133403 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.946239447314336 | 0.696358249006924 | 0.937453377971347 | 0.331144967260478 | 1.16891341386391E7 | 754837.409863468 | 4157779.88062054 | 5533917.143041036 | 2.9189343463191E7 | 2.94929696895869E7 | 4.96473559496876E7 | 3.610988970082183E7 | 1.04342545713823E7 | 8178713.43858634 | 1.18234267071803E7 | 1.0145464905716315E7 | 4.91534751033825E7 | 4.2865019365108E7 | 4.61937263356195E7 | 4.607074026803666E7 | 7275434.18699702 | 1.51319991253865E7 | 9682919.1999608 | 1.0696784170781441E7 | |
| Q69ZN7 | Myoferlin [OS=Mus musculus] | 112.647 | 22 | 36 | 227 | 36 | 2048 | 233.2 | cell organization and biogenesis;other metabolic processes;stress response;other biological processes | plasma membrane;other membranes;nucleus | other molecular function | 226101 | ENSMUSG00000048612 | Myof | mmu:226101; Q69ZN7; Q7TMG0; Q80V33; Q8BU64; Q8BU70; Q8BUC1; Q8BVY6; Q8C0D1; Q8R3B4 | 0.73657372909066 | 0.964709887217926 | 0.888974672311279 | 0.930955411749965 | 0.816275429153737 | 0.877818946381645 | 0.609903091678244 | 0.975029032316037 | 86000.3771233404 | 87234.2597428081 | 50456.7230101595 | 74563.786625436 | 780930.944201502 | 985609.680593147 | 968573.73043394 | 911704.7850761963 | 296294.389327177 | 289800.794039455 | 380995.072506467 | 322363.41862436634 | 3324626.35891918 | 3238695.05806667 | 2634093.62813707 | 3065805.015040973 | 993761.586050851 | 1295229.11918404 | 1025817.2029614 | 1104935.9693987637 | ||
| P26041 | Moesin [OS=Mus musculus] | 112.068 | 47 | 28 | 353 | 19 | 577 | 67.7 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function | 17698 | ENSMUSG00000031207 | Msn | B1AX70; mmu:17698; P26041; Q3UL28; Q8BSN4 | Regulation of actin cytoskeleton | Recycling pathway of L1 | 1.65082956259427E-17 | 0.0604972675946614 | 1.50457038391225E-17 | 0.157138696252226 | 0.910750689050232 | 0.682171843898269 | 0.97925982662951 | 0.954396180425051 | 3509434.20481405 | 4360753.56845675 | 2823311.97478394 | 3564499.916018247 | 1.57847182977139E7 | 1.58696599538661E7 | 1.95033967654703E7 | 1.7052591672350097E7 | 8383545.44173348 | 7552431.53754312 | 1.1473115873696E7 | 9136364.2843242 | 2.43209045148915E7 | 1.7265255344344E7 | 1.55060800034236E7 | 1.9030746620886367E7 | 1.24969658442338E7 | 1.31486313258361E7 | 7954804.76477835 | 1.120013397828275E7 |
| P05064 | Fructose-bisphosphate aldolase A [OS=Mus musculus] | 112.015 | 66 | 18 | 261 | 18 | 364 | 39.3 | cell organization and biogenesis;other metabolic processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | other molecular function | 11674 | ENSMUSG00000030695 | Aldoa | mmu:11674; P05064 | Glycolysis and gluconeogenesis | Platelet degranulation ; Neutrophil degranulation; Gluconeogenesis; Glycolysis | 0.101571037453114 | 0.00616383846364181 | 1.50457038391225E-17 | 0.0771819601934254 | 0.907383519445145 | 0.828577692034317 | 0.988377544628277 | 0.953305976192702 | 36553.7681309936 | 18014.3910425567 | 11156.0078725057 | 21908.055682018665 | 5538849.24179232 | 5285372.3367409 | 3856062.26656154 | 4893427.94836492 | 4263443.39983126 | 3386915.16711964 | 5306808.16889341 | 4319055.57861477 | 1.24814165546298E7 | 1.09515793948855E7 | 8528808.13475854 | 1.0653934694757948E7 | 4075248.71161469 | 5289067.55868911 | 4192052.54158905 | 4518789.603964283 |
| B2RQC6 | Multifunctional protein CAD [OS=Mus musculus] | 111.853 | 18 | 32 | 111 | 32 | 2225 | 243.1 | other metabolic processes;stress response;transport;developmental processes;other biological processes | cytosol;nucleus;other cell component | kinase activity;other molecular function | 69719 | ENSMUSG00000013629 | Cad | B2RQC6; B7ZN27; mmu:69719 | Mechanisms associated with pluripotency | Pyrimidine biosynthesis | 0.69394578118832 | 0.6681512188534 | 0.666244110962191 | 0.963127218853016 | 0.340675523776301 | 0.968897093792999 | 0.798180783050573 | 0.621633895543644 | 55886.6384121637 | 12993.9975368397 | 34438.2113153553 | 34439.61575478624 | 1026045.60319635 | 1025412.85494839 | 821784.178770446 | 957747.5456383955 | 383358.762218724 | 322831.339780162 | 640190.890369534 | 448793.6641228067 | 516093.312619156 | 478923.162373783 | 363366.537093714 | 452794.3373622177 | 110686.677299138 | 180829.981634378 | 127462.003140709 | 139659.55402474166 |
| Q8BND5 | Sulfhydryl oxidase 1 [OS=Mus musculus] | 111.186 | 35 | 22 | 242 | 22 | 748 | 82.7 | cell organization and biogenesis;other biological processes | non-structural extracellular;other membranes;ER/Golgi | other molecular function | 104009 | ENSMUSG00000033684 | Qsox1 | mmu:104009; Q3TDY9; Q3TE19; Q3TR29; Q3UEL4; Q8BND5; Q8K041; Q9DBL6 | Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Neutrophil degranulation | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 0.162753188077458 | 0.203109767081086 | 0.696358249006924 | 0.331332346840573 | 0.877612009404373 | 40119.4404166161 | 10016.9610840251 | 25068.200750320597 | 9134645.28263017 | 1.19624109837519E7 | 1.04856878607794E7 | 1.052758137572049E7 | 3750508.26959308 | 3765475.87858746 | 4032369.19900008 | 3849451.1157268733 | 5503994.64256118 | 5774708.06447186 | 3841814.38132964 | 5040172.36278756 | 1169677.75963505 | 2786812.01379908 | 1498357.95430882 | 1818282.5759143168 |
A
B
C
D
E
F
G
H
I
J
K
L
M
N
O
P
Q
R
S
T
U
V
W
X
Y
Z
AA
AB
AC
AD
AE
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
| Accession | Description | Sum PEP Score | Coverage [%] | # Peptides | # PSMs | # Unique Peptides | # AAs | MW [kDa] | Biological Process | Cellular Component | Molecular Function | Entrez Gene ID | Ensembl Gene ID | Gene Symbol | Gene ID | WikiPathways | Reactome Pathways | Abundance Ratio Adj. P-Value: (LQ_16h) / (FM) | Abundance Ratio Adj. P-Value: (LQ_6h) / (FM) | Abundance Ratio Adj. P-Value: (SQ_16h) / (FM) | Abundance Ratio Adj. P-Value: (SQ_6h) / (FM) | Abundance Ratio Adj. P-Value: (LQ_16h) / (LQ_6h) | Abundance Ratio Adj. P-Value: (SQ_6h) / (LQ_6h) | Abundance Ratio Adj. P-Value: (SQ_16h) / (SQ_6h) | FM_AVERAGE | LQ6h_AVERAGE | LQ16h_AVERAGE | SQ6h_AVERAGE | SQ16h_AVERAGE | |
| P11276 | Fibronectin [OS=Mus musculus] | 867.353 | 58 | 95 | 2246 | 59 | 2477 | 272.4 | cell adhesion;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi | signal transduction activity or receptor binding;enzyme regulator activity;other molecular function | 14268 | ENSMUSG00000026193 | Fn1 | G5E8B8; mmu:14268; P11276; Q61567; Q61568; Q61569; Q64233; Q80UI4 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Inflammatory response pathway; Regulation of actin cytoskeleton; Comprehensive IL-17A signaling; Focal adhesion | ECM proteoglycans; Platelet degranulation ; Cell surface interactions at the vascular wall; Syndecan interactions; MAP2K and MAPK activation; Integrin cell surface interactions; Molecules associated with elastic fibres; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Fibronectin matrix formation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; Degradation of the extracellular matrix; Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells; MET activates PTK2 signaling; GPER1 signaling | 0.0844744457809114 | 0.00584906503121538 | 1.50457038391225E-17 | 0.156115961659409 | 0.564710097967506 | 0.435823028559966 | 0.896613838854506 | 2.7641453377804603E7 | 2.022341523870097E8 | 2.12696235413058E8 | 1.2629719382404166E8 | 2.74958241507436E8 | |
| P11087 | Collagen alpha-1(I) chain [OS=Mus musculus] | 797.017 | 79 | 75 | 1933 | 35 | 1453 | 137.9 | cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12842 | ENSMUSG00000001506 | Col1a1 | mmu:12842; P11087; Q53WT0; Q60635; Q61367; Q61427; Q63919; Q6PCL3; Q810J9 | Osteoblast signaling; Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Comprehensive IL-17A signaling; Focal adhesion | Cell surface interactions at the vascular wall; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ECM proteoglycans; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; GPVI-mediated activation cascade; GP1b-IX-V activation signalling; Platelet Adhesion to exposed collagen; Platelet Aggregation (Plug Formation); MET activates PTK2 signaling | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.381922652011049 | 0.0629214061377862 | 0.655833157547641 | 772438.0834537543 | 2.0798706453114033E8 | 5.92854376184685E8 | 5.973622733379293E7 | 8.428319253806247E7 | |
| Q01149 | Collagen alpha-2(I) chain [OS=Mus musculus] | 773.662 | 80 | 66 | 1731 | 51 | 1372 | 129.5 | cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12843 | ENSMUSG00000029661 | Col1a2 | mmu:12843; Q01149; Q8CGA5 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Focal adhesion | Crosslinking of collagen fibrils; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; ECM proteoglycans; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; GPVI-mediated activation cascade; GP1b-IX-V activation signalling; Platelet Adhesion to exposed collagen; Platelet Aggregation (Plug Formation); MET activates PTK2 signaling | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.862063111456553 | 0.0347692006632991 | 0.926292871155025 | 182180.3275564673 | 1.7308392932505235E8 | 3.475967473053053E8 | 4.271481968913147E7 | 9.036410240893161E7 | |
| P08121 | Collagen alpha-1(III) chain [OS=Mus musculus] | 695.631 | 63 | 61 | 1789 | 51 | 1464 | 138.9 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | extracellular matrix;other cell component | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 12825 | ENSMUSG00000026043 | Col3a1 | mmu:12825; P08121; Q61429; Q9CRN7 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Focal adhesion | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ECM proteoglycans; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; MET activates PTK2 signaling | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.0413994480640273 | 0.394949139624895 | 0.976852696203657 | 454748.1180174556 | 6.282890624937943E7 | 2.8394661715058166E8 | 3.0365458724261332E7 | 6.6157215803336866E7 | |
| Q9QXS1 | Plectin [OS=Mus musculus] | 659.702 | 46 | 182 | 1705 | 180 | 4691 | 533.9 | cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component | cytoskeletal activity;other molecular function | 18810 | ENSMUSG00000022565 | Plec | E9QN87; mmu:18810; Q6S384; Q6S389; Q6S394; Q9CS65; Q9QUT2; Q9QXQ8; Q9QXQ9; Q9QXR0; Q9QXR1; Q9QXR2; Q9QXR3; Q9QXR4; Q9QXR5; Q9QXR6; Q9QXR7; Q9QXR8; Q9QXR9; Q9QXS0; Q9QXS1; Q9QXS2; Q9QXS3 | Alpha 6 beta 4 integrin signaling pathway; EGFR1 signaling pathway | Type I hemidesmosome assembly; Caspase-mediated cleavage of cytoskeletal proteins | 0.481729871164266 | 0.714932595871944 | 0.336550483871782 | 0.572524806937582 | 0.532399788858771 | 0.702330308974487 | 0.520376293994664 | 309922.514176982 | 4599273.114185064 | 1.6676006673579365E7 | 1.01501282886872E7 | 4.28490141732006E7 | |
| P08122 | Collagen alpha-2(IV) chain [OS=Mus musculus] | 526.992 | 64 | 69 | 1077 | 69 | 1707 | 167.2 | RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix | extracellular structural activity | 12827 | ENSMUSG00000031503 | Col4a2 | mmu:12827; P08122; Q3B7C2; Q3TPV9; Q61375; Q66JS5; Q6RCT6; Q6RCT7; Q6U9X1; Q8BPI9; Q8BPK3; Q91VI3 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Focal adhesion | Laminin interactions; Signaling by PDGF; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions | 0.352816378116182 | 0.64759425713406 | 0.293387877727491 | 0.79866917976589 | 0.169673447599406 | 0.959159975702413 | 0.483015668880262 | 1393534.8123072747 | 1.3981747232493034E7 | 5.0194805286054574E7 | 1.701609057115766E7 | 5.972856146483746E7 | |
| Q3U962 | Collagen alpha-2(V) chain [OS=Mus musculus] | 518.514 | 64 | 57 | 817 | 55 | 1497 | 144.9 | cell organization and biogenesis;developmental processes;other biological processes | extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12832 | ENSMUSG00000026042 | Col5a2 | mmu:12832; Q3TVR2; Q3U962; Q3UHK7; Q3UTT4; Q3V1J6; Q61431; Q7TMS0; Q80VS8 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions | 0.861384746267066 | 0.961254912149485 | 0.730324052254867 | 0.632833892117728 | 0.273444295895674 | 0.453486790198347 | 0.973358018692255 | 2.4419841082594533E7 | 1.5753424919239333E7 | 4.592471970087584E7 | 1.0471363011153279E7 | 2.1079551940947264E7 | |
| Q05793 | Basement membrane-specific heparan sulfate proteoglycan core protein [OS=Mus musculus] | 507.28 | 33 | 84 | 998 | 84 | 3707 | 398 | cell organization and biogenesis;transport;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;ER/Golgi | other molecular function | 15530 | Hspg2 | mmu:15530; Q05793 | 0.332090710292395 | 0.382764581022518 | 0.771134174410141 | 0.553652046981626 | 0.938381933295379 | 0.285967432697218 | 0.908661395894721 | 171009.25706548532 | 2.1355561683383033E7 | 4.109385814368304E7 | 8244737.341084313 | 1.8998181152407136E7 | ||||
| Q61554 | Fibrillin-1 [OS=Mus musculus] | 499.202 | 38 | 86 | 1117 | 86 | 2873 | 312.1 | cell adhesion;other metabolic processes;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 14118 | ENSMUSG00000027204 | Fbn1 | A2AQ53; mmu:14118; Q60826; Q61554 | Comprehensive IL-17A signaling | Integrin cell surface interactions; Degradation of the extracellular matrix; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; TGF-beta receptor signaling activates SMADs; Molecules associated with elastic fibres | 0.0596853092747711 | 0.0840496117897429 | 0.378389090130589 | 0.84258396038376 | 0.862063111456553 | 0.0455630470425967 | 0.77820123247099 | 81731.837224874 | 2.17735814942991E7 | 5.216417896597137E7 | 5145074.9913376765 | 2.082557122129057E7 | |
| Q8BTM8 | Filamin-A [OS=Mus musculus] | 493.069 | 49 | 91 | 915 | 83 | 2647 | 281 | cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;other molecular function | 192176 | ENSMUSG00000031328 | Flna | B7FAV0; O54934; Q7TQI1; Q8BLK1; Q8BTM8; Q8BTN7; Q8VHX5; Q8VHX8; Q99KQ2 | Mapk signaling pathway; Focal adhesion | Platelet degranulation ; Cell-extracellular matrix interactions; RHO GTPases activate PAKs; GP1b-IX-V activation signalling | 0.0844935092512095 | 0.493514006575528 | 0.170420349138264 | 0.67528135146603 | 0.864215513767001 | 0.904360680536565 | 0.8468455705593 | 218480.8558628913 | 4952287.405198824 | 1.1395384793048913E7 | 4296604.098486893 | 1.4686023116833666E7 | |
| P02463 | Collagen alpha-1(IV) chain [OS=Mus musculus] | 487.707 | 70 | 68 | 828 | 68 | 1669 | 160.6 | cell organization and biogenesis;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix | extracellular structural activity;other molecular function | 12826 | ENSMUSG00000031502 | Col4a1 | mmu:12826; P02463; Q3UHJ4; Q3UJE7; Q3UQV2; Q53X35; Q6GQS7; Q6PHB5; Q99LQ8 | Spinal cord injury; Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Laminin interactions; Signaling by PDGF; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions | 0.604225174343649 | 0.68008321917751 | 0.284160251285083 | 0.936818656936794 | 0.167300285011781 | 0.777395712279767 | 0.224623005929948 | 262271.417553364 | 4620515.057112186 | 2.1463797748519864E7 | 8911949.32392111 | 3.3156314746725336E7 | |
| Q60847 | Collagen alpha-1(XII) chain [OS=Mus musculus] | 480.266 | 40 | 95 | 991 | 95 | 3120 | 340 | cell adhesion;developmental processes | other cell component | 12816 | ENSMUSG00000032332 | Col12a1 | mmu:12816; P70322; Q60847 | Assembly of collagen fibrils and other multimeric structures; Collagen chain trimerization; Collagen degradation | 0.0975092237649803 | 1.8644578313253E-17 | 0.344512840834051 | 0.162753188077458 | 0.101350980560035 | 0.0103905836841461 | 0.266844028199729 | 80180.17821443231 | 5.1736330625803865E7 | 2.9952489655588504E7 | 1.0537780206453351E7 | 1.4629541968462234E7 | |||
| Q8VDD5 | Myosin-9 [OS=Mus musculus] | 418.364 | 45 | 73 | 827 | 60 | 1960 | 226.2 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;stress response;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;other molecular function | 17886 | ENSMUSG00000022443 | Myh9 | mmu:17886; Q3UHT9; Q3UHU4; Q6KAN6; Q811I2; Q8VDD5 | Primary focal segmental glomerulosclerosis (FSGS) | RHO GTPases activate PAKs; Regulation of actin dynamics for phagocytic cup formation | 0.156498497144098 | 0.0382609387499984 | 0.118876667035285 | 0.15125389278925 | 0.916542675526027 | 0.91728043005175 | 0.990873516209569 | 100319.6147091511 | 5176534.940650649 | 8067345.413832072 | 7844465.70271172 | 1.9759662960152034E7 | |
| Cont_P02453 | Collagen alpha-1(I) chain OS=Bos taurus OX=9913 GN=COL1A1 PE=1 SV=3 | 414.689 | 43 | 43 | 1208 | 4 | 1463 | 138.9 | cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | 282187 | ENSBTAG00000013103 | COL1A1 | bta:282187; P02453; Q3MHM2 | Inflammatory response pathway; Osteoblast signaling; Focal adhesion | Fibronectin matrix formation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Collagen degradation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; Collagen chain trimerization; GPVI-mediated activation cascade; Platelet Aggregation (Plug Formation); Platelet Adhesion to exposed collagen; GP1b-IX-V activation signalling | 0.800889767710788 | 0.579410556046386 | 0.58548007712969 | 0.839216523231753 | 0.848119069115724 | 0.108042253370914 | 0.0107964100780951 | 228542.54091026666 | 3262486.7198886867 | 3910059.36528234 | 1102058.9569362423 | 924822.5329095138 | |
| Cont_P02769 | Albumin OS=Bos taurus OX=9913 GN=ALB PE=1 SV=4 | 390.555 | 81 | 57 | 7095 | 54 | 607 | 69.2 | stress response;other biological processes | non-structural extracellular;other cell component | nucleic acid binding activity;other molecular function | 280717 | ALB | A5PJX3; bta:280717; O02787; P02769; P04277; Q3SZR2 | 0.520832629933248 | 0.650544967914241 | 0.598172767155558 | 0.497906326712893 | 0.413798631523592 | 0.846117085258013 | 0.468531677746422 | 2.7142766432154403E9 | 2.9099571807541137E9 | 2.4034772237737E9 | 2.38097622607819E9 | 2.6841204207378564E9 | ||||
| P01027 | Complement C3 [OS=Mus musculus] | 388.541 | 53 | 70 | 1148 | 62 | 1663 | 186.4 | cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular;other cell component | signal transduction activity or receptor binding;enzyme regulator activity | 12266 | ENSMUSG00000024164 | C3 | mmu:12266; P01027; Q61370; Q80XP1 | Complement activation, classical pathway; Tyrobp causal network in microglia; Comprehensive IL-17A signaling | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade; Neutrophil degranulation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; G alpha (i) signalling events; Peptide ligand-binding receptors; Alternative complement activation; Activation of C3 and C5 | 0.712660037675161 | 0.729783028721347 | 0.506101547380209 | 0.762068821001752 | 0.512232143465318 | 0.413470300505934 | 0.991722673088443 | 3269916.660849947 | 1.6657146132333001E7 | 4.4549110086954266E7 | 3.6733221642207734E7 | 8.026680998659676E7 | |
| Cont_Q7SIH1 | Alpha-2-macroglobulin OS=Bos taurus OX=9913 GN=A2M PE=1 SV=2 | 370.864 | 53 | 56 | 1089 | 56 | 1510 | 167.5 | non-structural extracellular | enzyme regulator activity;other molecular function | 513856 | ENSBTAG00000018137 | A2M | A8E647; bta:513856; Q7SIH1 | IL-6 signaling pathway | 0.688450665125024 | 0.839052280267302 | 0.731111241255251 | 0.509007335932165 | 0.540124873725708 | 0.671798309985569 | 0.809503222445875 | 5.423624331449187E7 | 7.564994624258716E7 | 7.018676700369896E7 | 5.23492843648457E7 | 8.250822323914327E7 | |||
| Cont_Q29443 | Serotransferrin OS=Bos taurus OX=9913 GN=TF PE=2 SV=1 | 343.183 | 74 | 48 | 1709 | 46 | 704 | 77.7 | stress response;transport;other biological processes | non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle | other molecular function | 280705 | TF | bta:280705; Q0IIK2; Q29443 | 0.615274986253429 | 0.964709887217926 | 0.600414647182016 | 0.571407162236119 | 0.105569810421019 | 0.506704636011438 | 0.313748671859839 | 1.48932090998098E8 | 2.32106703986673E8 | 1.5606409762411097E8 | 1.3567523181654152E8 | 1.6257112433260167E8 | ||||
| Cont_P07589 | Fibronectin OS=Bos taurus OX=9913 GN=FN1 PE=1 SV=4 | 337.517 | 26 | 47 | 923 | 11 | 2478 | 272 | cell adhesion;cell organization and biogenesis;stress response;developmental processes;other biological processes | non-structural extracellular | signal transduction activity or receptor binding;other molecular function | FN1 | P07589 | 0.714071857030863 | 0.525827426782658 | 0.94971810013306 | 0.802863674292211 | 0.634088329627404 | 0.35834247597224 | 0.281927255363179 | 166255.75410196633 | 835883.8306505851 | 952169.9232567847 | 482619.7682389803 | 602598.7403397557 | |||||
| Q80X90 | Filamin-B [OS=Mus musculus] | 335.882 | 38 | 75 | 608 | 66 | 2602 | 277.7 | cell organization and biogenesis;stress response;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 286940 | ENSMUSG00000025278 | Flnb | E9QNV9; mmu:286940; Q80X90; Q8VHX4; Q8VHX7; Q99KY3 | ISG15 antiviral mechanism | 0.296944306247309 | 0.238365792894698 | 0.254729742039053 | 0.629546282386664 | 0.897564267605108 | 0.872448101434609 | 0.866446545996913 | 154624.23024854946 | 2351112.5534752235 | 6048828.490809467 | 1865154.4144755967 | 7592568.170254476 | ||
| Cont_P35527 | Keratin, type I cytoskeletal 9 OS=Homo sapiens OX=9606 GN=KRT9 PE=1 SV=3 | 310.424 | 69 | 35 | 915 | 34 | 623 | 62 | cell organization and biogenesis;other biological processes | cytosol;cytoskeleton | cytoskeletal activity | 3857 | ENSG00000171403 | KRT9 | hsa:3857; O00109; P35527; Q0IJ47; Q14665 | Formation of the cornified envelope | 0.836660982916281 | 0.73072258897653 | 0.769556732848094 | 0.964570089320365 | 0.936669139837906 | 0.516448827835279 | 0.0110179641295352 | 2.9224080803851068E7 | 3.250630567014273E7 | 4.1318104811136335E7 | 9.369998400542612E7 | 5.1433611479478456E7 | ||
| Cont_P04264 | Keratin, type II cytoskeletal 1 OS=Homo sapiens OX=9606 GN=KRT1 PE=1 SV=6 | 306.58 | 65 | 45 | 1774 | 36 | 644 | 66 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;other molecular function | 3848 | ENSG00000167768 | KRT1 | B2RA01; hsa:3848; P04264; P85925; P86104; Q14720; Q6GSJ0; Q9H298 | Corticotropin-releasing hormone signaling | Formation of the cornified envelope; Neutrophil degranulation; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.65780924735352 | 0.653826967689551 | 0.631165145316661 | 0.89629386854896 | 0.770634810212039 | 0.254077056479593 | 5.78940441291519E-5 | 1.5397854514739665E8 | 1.3414412508194733E8 | 1.6528138436319932E8 | 4.476405570139613E8 | 1.7631437693719265E8 | |
| P06909 | Complement factor H [OS=Mus musculus] | 292.01 | 49 | 41 | 540 | 41 | 1234 | 139 | cell adhesion;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes | non-structural extracellular;plasma membrane;other membranes;mitochondrion;other cell component | other molecular function | 12628 | ENSMUSG00000026365 | Cfh | mmu:12628; P06909; Q6NZK3 | Regulation of Complement cascade | 0.205200089226065 | 0.0359547312524068 | 1.50457038391225E-17 | 0.329485122608543 | 0.532399788858771 | 0.750662231008662 | 0.443116920082088 | 59542.32714759521 | 1.0566840244224759E7 | 1.036081717107911E7 | 8439848.284125684 | 2.9357524779450033E7 | ||
| P16546 | Spectrin alpha chain, non-erythrocytic 1 [OS=Mus musculus] | 291.854 | 35 | 74 | 473 | 74 | 2472 | 284.4 | cell organization and biogenesis | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 20740 | ENSMUSG00000057738 | Sptan1 | A3KGU6; A3KGU8; P16546; Q8K380; Q9CT05 | FAS pathway and stress induction of HSP regulation | Neutrophil degranulation; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Interaction between L1 and Ankyrins; COPI-mediated anterograde transport; RHOU GTPase cycle; RHOV GTPase cycle; Caspase-mediated cleavage of cytoskeletal proteins | 0.958962194559628 | 0.786160319109602 | 0.611910908670005 | 0.890289034593217 | 0.771887919257916 | 0.870511801558508 | 0.852906094467594 | 684626.7741473566 | 1427277.73205798 | 3976922.979229001 | 2263434.85725903 | 8138355.29233573 | |
| Cont_P13645 | Keratin, type I cytoskeletal 10 OS=Homo sapiens OX=9606 GN=KRT10 PE=1 SV=6 | 286.713 | 62 | 30 | 1322 | 20 | 584 | 58.8 | cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes | plasma membrane;cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;other molecular function | 3858 | ENSG00000186395 | KRT10 | hsa:3858; P13645; Q14664; Q8N175 | Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.600890052902075 | 0.490821286240141 | 0.561934876627864 | 0.941696908693733 | 0.880940844456856 | 0.246231694954624 | 2.55433624902191E-5 | 1.1091978559495355E8 | 9.409796786421584E7 | 1.13950700113199E8 | 3.19749190691826E8 | 1.0914077913761683E8 | ||
| Cont_P35908 | Keratin, type II cytoskeletal 2 epidermal OS=Homo sapiens OX=9606 GN=KRT2 PE=1 SV=2 | 284.975 | 78 | 42 | 1022 | 32 | 639 | 65.4 | cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes | plasma membrane;cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;cytoskeletal activity | 3849 | ENSG00000172867 | KRT2 | hsa:3849; P35908; Q4VAQ2 | Formation of the cornified envelope | 0.499413631103761 | 0.411258958244596 | 0.544106843431104 | 0.933570718645937 | 0.862063111456553 | 0.309041843038519 | 2.9837536993241E-4 | 4.776750778997586E7 | 2.9357809740500167E7 | 3.415287514761583E7 | 7.640800383787991E7 | 3.617272663897294E7 | ||
| Q62059 | Versican core protein [OS=Mus musculus] | 279.715 | 17 | 44 | 1073 | 44 | 3357 | 366.6 | cell adhesion;developmental processes | non-structural extracellular;extracellular matrix;other cell component | other molecular function | Vcan | Q62058; Q62059; Q9CUU0 | ECM proteoglycans; Glycosaminoglycan-protein linkage region biosynthesis; CS/DS degradation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; CS-GAG biosynthesis; DS-GAG biosynthesis | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.613304974369123 | 0.478009151463064 | 0.783304059803245 | 104188.56292801573 | 9.037034497028168E7 | 9.467651077277745E7 | 5.89459061512507E7 | 9.510262638582683E7 | ||||
| P10493 | Nidogen-1 [OS=Mus musculus] | 275.191 | 43 | 42 | 852 | 42 | 1245 | 136.5 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | other molecular function | 18073 | ENSMUSG00000005397 | Nid1 | mmu:18073; P10493; Q3TKX9; Q8BQI3; Q8C3U8; Q8C9P6 | Laminin interactions; Degradation of the extracellular matrix | 1.65082956259427E-17 | 1.8644578313253E-17 | 0.251140212279038 | 0.461941385639594 | 0.604382524464811 | 1.0740690550749E-5 | 0.781368126060588 | 322455.2944414853 | 1.2120394496125467E8 | 1.2671518083095133E8 | 9146738.193898173 | 3.1971627034095198E7 | ||
| O88207 | Collagen alpha-1(V) chain [OS=Mus musculus] | 275.025 | 46 | 52 | 413 | 44 | 1838 | 183.6 | cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes | extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12831 | ENSMUSG00000026837 | Col5a1 | A3KGE3; mmu:12831; O88207; Q3UG94; Q6F6B0 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | ECM proteoglycans; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; MET activates PTK2 signaling | 1.65082956259427E-17 | 1.8644578313253E-17 | 0.268653947705267 | 0.311207075116757 | 0.848119069115724 | 0.302671730722046 | 0.809503222445875 | 80388.83753211687 | 3577832.3612721 | 8562033.320911517 | 1386447.3981625708 | 3098568.0509616495 | |
| P37889 | Fibulin-2 [OS=Mus musculus] | 269.894 | 43 | 37 | 791 | 37 | 1221 | 131.7 | other biological processes | non-structural extracellular | other molecular function | 14115 | ENSMUSG00000064080 | Fbln2 | G5E8B3; mmu:14115; P37889; Q9WUI2 | Molecules associated with elastic fibres | 1.65082956259427E-17 | 0.0640195441309023 | 0.201227492083465 | 0.255240026777032 | 0.803447472095846 | 0.290132264062119 | 0.809503222445875 | 362692.0010392267 | 6.556805587417743E7 | 8.021475911820169E7 | 3.00676966042863E7 | 4.93487108032657E7 | ||
| Q8VHX6 | Filamin-C [OS=Mus musculus] | 249.498 | 31 | 65 | 425 | 56 | 2726 | 290.9 | cell organization and biogenesis;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity | 68794 | ENSMUSG00000068699 | Flnc | B2RY80; B9EKT2; mmu:68794; Q6PAI6; Q8VHX6; Q9JJ38 | Cell-extracellular matrix interactions | 0.562594032195739 | 0.719627996749639 | 0.962331548063155 | 0.57290809187594 | 0.96786708205164 | 0.933437821008547 | 0.80954066750699 | 406087.97266412666 | 1016453.1391661359 | 2089599.8263247435 | 1136666.5742976035 | 4459384.47065665 | ||
| Q04857 | Collagen alpha-1(VI) chain [OS=Mus musculus] | 248.981 | 44 | 33 | 588 | 33 | 1025 | 108.4 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component | other molecular function | 12833 | ENSMUSG00000001119 | Col6a1 | mmu:12833; Q04857 | ECM proteoglycans; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Signaling by PDGF; NCAM1 interactions | 0.2534363617947 | 0.392208211277376 | 0.962331548063155 | 0.971216996811237 | 0.97504218639442 | 0.115965329440656 | 0.380888676065133 | 76865.2077476112 | 5.0068940213435836E7 | 6.914260176814564E7 | 1.4473176745930666E7 | 1.9886194591010433E7 | ||
| Cont_Q2UVX4 | Complement C3 OS=Bos taurus OX=9913 GN=C3 PE=1 SV=2 | 247.154 | 39 | 55 | 851 | 47 | 1661 | 187.1 | cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular;other cell component | signal transduction activity or receptor binding;enzyme regulator activity | 280677 | ENSBTAG00000017280 | C3 | bta:280677; Q2KIZ4; Q2UVX4 | Complement and coagulation cascades; Complement activation, classical pathway | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Neutrophil degranulation; Peptide ligand-binding receptors; G alpha (i) signalling events; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade; Alternative complement activation; Activation of C3 and C5 | 0.615680953989958 | 0.798729234704005 | 0.573945385766997 | 0.506364847510615 | 0.291700662163587 | 0.591028379533681 | 0.448532796991499 | 1.4686759191254234E7 | 1.84550126489547E7 | 1.5291804049274266E7 | 1.196234797265725E7 | 1.6127794015790733E7 | |
| Q62261 | Spectrin beta chain, non-erythrocytic 1 [OS=Mus musculus] | 244.684 | 30 | 61 | 398 | 61 | 2363 | 274.1 | cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 20742 | ENSMUSG00000020315 | Sptbn1 | A2AFU1; mmu:20742; Q3TEM7; Q5SQL8; Q5SQL9; Q62261; Q9QWJ7 | COPI-mediated anterograde transport; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; RHOU GTPase cycle; Interaction between L1 and Ankyrins; RHOV GTPase cycle | 0.69394578118832 | 0.776437620310661 | 0.693719649766064 | 0.831411077141515 | 0.86315143463057 | 0.664971370235365 | 0.953305976192702 | 492454.03878621367 | 920886.7046363313 | 2921004.358024217 | 2299979.2063157237 | 6417771.720584608 | ||
| Q640N1 | Adipocyte enhancer-binding protein 1 [OS=Mus musculus] | 239.707 | 38 | 34 | 648 | 34 | 1128 | 128.3 | protein metabolism;other biological processes | nucleus;other cell component | nucleic acid binding activity;other molecular function | 11568 | ENSMUSG00000020473 | Aebp1 | mmu:11568; O88442; Q3TVV5; Q3TWA7; Q3TX56; Q3TXB2; Q5NCI9; Q61281; Q640N1 | 0.269326617826563 | 0.0457359864845759 | 0.605387748357992 | 0.631359014803774 | 0.760992448481534 | 0.145805028390539 | 0.963436677882021 | 4843934.666021533 | 3.9556778473622136E7 | 4.1143769603117764E7 | 1.8648394999714002E7 | 3.1901344171106894E7 | |||
| P57780 | Alpha-actinin-4 [OS=Mus musculus] | 239.42 | 58 | 45 | 483 | 30 | 912 | 104.9 | cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes | cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 60595 | ENSMUSG00000054808 | Actn4 | mmu:60595; P57780 | Primary focal segmental glomerulosclerosis (FSGS) | Platelet degranulation | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 0.19149089837131 | 0.795351011232032 | 0.968364585136618 | 0.938282411159324 | 20900.169415734228 | 4580996.01302682 | 9830280.285985528 | 4440337.50144963 | 1.1658414413951913E7 | |
| Q7TPR4 | Alpha-actinin-1 [OS=Mus musculus] | 235.529 | 54 | 42 | 511 | 27 | 892 | 103 | cell adhesion;cell organization and biogenesis;other biological processes | plasma membrane;other membranes;cytoskeleton;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function | 109711 | ENSMUSG00000015143 | Actn1 | mmu:109711; Q7TPR4 | Regulation of actin cytoskeleton; Integrin-mediated cell adhesion; Focal adhesion | Platelet degranulation ; RHOF GTPase cycle; RHOBTB2 GTPase cycle; RHOD GTPase cycle; Regulation of cytoskeletal remodeling and cell spreading by IPP complex components | 0.995554138371554 | 0.178726136005694 | 0.819280225722906 | 0.941696908693733 | 0.744084716394381 | 0.837231569641376 | 0.879972045955715 | 486802.1989182571 | 2525588.7379033365 | 6210475.170240924 | 3717490.65968503 | 9946958.94260729 | |
| P02468 | Laminin subunit gamma-1 [OS=Mus musculus] | 230.882 | 35 | 43 | 454 | 43 | 1607 | 177.2 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | Lamc1 | P02468 | 0.118212047511996 | 0.116315527815218 | 0.459134305737471 | 0.675951294045723 | 0.877818946381645 | 0.368062651583427 | 0.922276466908065 | 18104.5719498812 | 7327169.184632126 | 1.61740059690847E7 | 3246292.9185144133 | 7951596.802164167 | |||||
| Q91ZX7 | Prolow-density lipoprotein receptor-related protein 1 [OS=Mus musculus] | 230.497 | 15 | 57 | 519 | 56 | 4545 | 504.4 | other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;other molecular function | 16971 | Lrp1 | mmu:16971; Q61291; Q91ZX7; Q920Y4 | Statin pathway; Wnt signaling pathway | Scavenging of heme from plasma; Retinoid metabolism and transport | 1.65082956259427E-17 | 0.0181625429641231 | 0.133639440745791 | 0.150830220548111 | 0.925871264502428 | 0.74148782464906 | 0.901098484497789 | 30670.78727387535 | 3548407.5296101067 | 7355877.025944923 | 2243610.9879279765 | 5724840.5342227295 | ||
| Cont_P60712 | Actin, cytoplasmic 1 OS=Bos taurus OX=9913 GN=ACTB PE=1 SV=1 | 225.45 | 70 | 19 | 852 | 2 | 375 | 41.7 | cell organization and biogenesis;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component | enzyme regulator activity;cytoskeletal activity;other molecular function | 100033878; 100135470; 100173832; 101844587; 102139853; 11461; 118833809; 280979; 396526; 403580; 414396; 443052; 450133; 60; 81822 | ENSBTAG00000026199; ENSCAFG00000016020; ENSCAFG00030015381; ENSCAFG00040015695; ENSCPOG00000013467; ENSG00000075624; ENSMAUG00000008763; ENSMUSG00000029580; ENSOARG00040012985; ENSOARG00180022443; ENSOARG00185023855; ENSOARG00215030140; ENSOARG00225009314; ENSPPYG00000017336; ENSPTRG00000018890; ENSRNOG00000034254; ENSSSCG00000007585; ENSSSCG00030003451; ENSSSCG00035038792; ENSSSCG00040049462; ENSSSCG00045027458; ENSSSCG00050065025; ENSSSCG00055012597; ENSSSCG00060019124; ENSSSCG00065037921; ENSSSCG00070011353; ENSSSCG00105030144; ENSSSCG00110026965; ENSSSCG00115013637; ENSSSCG00130033784 | Actb; ACTB | A5D961; A5PKA1; bta:280979; cfa:403580; cpoc:100135470; csab:103246953; ecb:100033878; gga:396526; hsa:60; maua:101844587; mmu:11461; O18840; oas:443052; P02570; P60706; P60707; P60708; P60709; P60710; P60711; P60712; P60713; P70514; P99021; pon:100173832; ptr:450133; Q11209; Q11211; Q3SZD2; Q3TI89; Q3TVP6; Q4L0Y2; Q4R561; Q5R1X3; Q5R582; Q5R6G0; Q64316; Q6QAQ1; Q6ZWM3; Q711N9; Q71FK5; Q75MN2; Q76N69; Q8MIJ0; Q8SPX4; Q95164; Q96B34; Q96HG5; rno:81822; ssc:414396 | FAS pathway and stress induction of HSP regulation; Actin cytoskeleton regulation; Myometrial relaxation and contraction pathways; Focal adhesion; Arrhythmogenic right ventricular cardiomyopathy; Pathogenic Escherichia coli infection; Common pathways underlying drug addiction; Myometrial relaxation and contraction pathways; Focal adhesion; Fas ligand pathway and stress induction of heat shock proteins; Pathogenic Escherichia coli infection; Arrhythmogenic right ventricular cardiomyopathy; Focal adhesion; Myometrial relaxation and contraction pathways; Regulation of actin cytoskeleton; Myometrial relaxation and contraction pathways; Ebola virus infection in host; Acute viral myocarditis; Thermogenesis; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Overlap between signal transduction pathways contributing to LMNA laminopathies; Pleural mesothelioma; Regulation of actin cytoskeleton; Network map of SARS-CoV-2 signaling; Regulation of actin cytoskeleton; Regulation of actin cytoskeleton; Focal adhesion | Formation of the canonical BAF (cBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); Regulation of actin dynamics for phagocytic cup formation; EPH-ephrin mediated repulsion of cells; Formation of annular gap junctions; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; RHO GTPases Activate Formins; RHOF GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; B-WICH complex positively regulates rRNA expression; Regulation of CDH1 Function; Formation of the dystrophin-glycoprotein complex (DGC); Formation of the canonical BAF (cBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); RHO GTPases Activate WASPs and WAVEs; UCH proteinases; DNA Damage Recognition in GG-NER; Formation of the non-canonical BAF (ncBAF) complex; RHO GTPases activate IQGAPs; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Cell-extracellular matrix interactions; MAP2K and MAPK activation; Interaction between L1 and Ankyrins; RHOF GTPase cycle; DNA Damage Recognition in GG-NER; MAP2K and MAPK activation; RHO GTPases Activate Formins; Clathrin-mediated endocytosis; UCH proteinases; RHOF GTPase cycle; DNA Damage Recognition in GG-NER; EPH-ephrin mediated repulsion of cells; VEGFA-VEGFR2 Pathway; Regulation of actin dynamics for phagocytic cup formation; Adherens junctions interactions; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); RHO GTPases Activate WASPs and WAVEs; B-WICH complex positively regulates rRNA expression; Regulation of CDH1 Function; EPHB-mediated forward signaling; Formation of the non-canonical BAF (ncBAF) complex; Formation of the canonical BAF (cBAF) complex; Formation of annular gap junctions; RHO GTPases activate IQGAPs; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; RHO GTPases Activate WASPs and WAVEs; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RHO GTPases activate IQGAPs; RHO GTPases Activate Formins; RHOF GTPase cycle; Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs); B-WICH complex positively regulates rRNA expression; Signaling by BRAF and RAF1 fusions; UCH proteinases; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; VEGFA-VEGFR2 Pathway; Formation of the dystrophin-glycoprotein complex (DGC); Factors involved in megakaryocyte development and platelet production; Regulation of MITF-M-dependent genes involved in pigmentation; Formation of the canonical BAF (cBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); EPH-ephrin mediated repulsion of cells; HATs acetylate histones; Interaction between L1 and Ankyrins; Prefoldin mediated transfer of substrate to CCT/TriC; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Adherens junctions interactions; Regulation of CDH1 Function; Formation of the non-canonical BAF (ncBAF) complex; DNA Damage Recognition in GG-NER; Formation of the polybromo-BAF (pBAF) complex; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Formation of annular gap junctions; Folding of actin by CCT/TriC; Cell-extracellular matrix interactions; MAP2K and MAPK activation; RHO GTPases Activate Formins; Recycling pathway of L1; RHO GTPases activate IQGAPs; Clathrin-mediated endocytosis; Formation of the dystrophin-glycoprotein complex (DGC); EPHB-mediated forward signaling; UCH proteinases; B-WICH complex positively regulates rRNA expression; Adherens junctions interactions; Formation of the non-canonical BAF (ncBAF) complex; Formation of annular gap junctions; Formation of the polybromo-BAF (pBAF) complex; VEGFA-VEGFR2 Pathway; Cell-extracellular matrix interactions; RHO GTPases Activate WASPs and WAVEs; Regulation of CDH1 Function; Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; UCH proteinases; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); Formation of the polybromo-BAF (pBAF) complex; B-WICH complex positively regulates rRNA expression; DNA Damage Recognition in GG-NER; Formation of the canonical BAF (cBAF) complex; RHO GTPases Activate Formins; Regulation of CDH1 Function; Interaction between L1 and Ankyrins; RHOF GTPase cycle; Formation of the non-canonical BAF (ncBAF) complex; Adherens junctions interactions; Formation of the dystrophin-glycoprotein complex (DGC); VEGFA-VEGFR2 Pathway; RHO GTPases Activate WASPs and WAVEs; Cell-extracellular matrix interactions; EPHB-mediated forward signaling; MAP2K and MAPK activation; Recycling pathway of L1; RHO GTPases activate IQGAPs; Formation of annular gap junctions; B-WICH complex positively regulates rRNA expression; UCH proteinases; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); MAP2K and MAPK activation; Formation of the polybromo-BAF (pBAF) complex; RHO GTPases Activate Formins; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases Activate WASPs and WAVEs; Formation of the dystrophin-glycoprotein complex (DGC); VEGFA-VEGFR2 Pathway; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; DNA Damage Recognition in GG-NER; RHOF GTPase cycle; Cell-extracellular matrix interactions; Adherens junctions interactions; Formation of the non-canonical BAF (ncBAF) complex; Formation of the canonical BAF (cBAF) complex; RHO GTPases activate IQGAPs; Regulation of CDH1 Function; Gap junction degradation; Formation of annular gap junctions; Regulation of actin dynamics for phagocytic cup formation; RHOF GTPase cycle; Clathrin-mediated endocytosis; RHO GTPases Activate Formins; Cell-extracellular matrix interactions; VEGFA-VEGFR2 Pathway; Adherens junctions interactions; RHO GTPases activate IQGAPs; UCH proteinases; EPHB-mediated forward signaling; MAP2K and MAPK activation; RHO GTPases Activate WASPs and WAVEs; Formation of the dystrophin-glycoprotein complex (DGC); Formation of annular gap junctions; Formation of the canonical BAF (cBAF) complex; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of the non-canonical BAF (ncBAF) complex; Regulation of CDH1 Function | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.994348552930242 | 0.963278515868644 | 0.938282411159324 | 1996659.4544256767 | 4.828873920581084E7 | 6.5074451419171505E7 | 5.335770948168167E7 | 1.0984219759318356E8 | |
| P63260 | Actin, cytoplasmic 2 [OS=Mus musculus] | 217.791 | 70 | 19 | 831 | 2 | 375 | 41.8 | cell organization and biogenesis;stress response;developmental processes;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 11465 | ENSMUSG00000062825 | Actg1 | mmu:11465; P02571; P14104; P63260; P99022 | Myometrial relaxation and contraction pathways; Regulation of actin cytoskeleton; Focal adhesion | Platelet degranulation ; RHO GTPases activate IQGAPs; Adherens junctions interactions; Regulation of CDH1 Function; RHO GTPases Activate Formins; Regulation of actin dynamics for phagocytic cup formation; Interaction between L1 and Ankyrins; MAP2K and MAPK activation; Recycling pathway of L1; Clathrin-mediated endocytosis; Formation of the dystrophin-glycoprotein complex (DGC); EPHB-mediated forward signaling; RHOF GTPase cycle; Formation of annular gap junctions; VEGFA-VEGFR2 Pathway; Cell-extracellular matrix interactions; RHO GTPases Activate WASPs and WAVEs; RHOBTB2 GTPase cycle | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.901789796153066 | 0.731487178650893 | 0.819844267712751 | 145698.54484736864 | 254666.434448248 | 126248.83655432604 | 256671.2110968777 | ||
| P33434 | 72 kDa type IV collagenase [OS=Mus musculus] | 212.03 | 56 | 30 | 889 | 30 | 662 | 74.1 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes | extracellular matrix;plasma membrane;other membranes;cytoskeleton;mitochondrion;nucleus;other cell component | other molecular function | 17390 | ENSMUSG00000031740 | Mmp2 | mmu:17390; P33434 | Lung fibrosis; IL-3 signaling pathway; Matrix metalloproteinases | Collagen degradation; Extra-nuclear estrogen signaling; EPH-ephrin mediated repulsion of cells; Activation of Matrix Metalloproteinases | 0.372996577396536 | 0.964209443670126 | 0.342075680986172 | 0.708142491896103 | 0.459747209584207 | 0.34519376377552 | 0.809503222445875 | 2.5908623508144036E7 | 2.11513119484971E7 | 6.116415043649567E7 | 5.359802560613743E7 | 8.73371018908004E7 | |
| P19096 | Fatty acid synthase [OS=Mus musculus] | 203.372 | 23 | 48 | 335 | 48 | 2504 | 272.3 | other metabolic processes;stress response;other biological processes | plasma membrane;other membranes;cytosol;ER/Golgi;other cell component | other molecular function | 14104 | ENSMUSG00000025153 | Fasn | B1ATU8; mmu:14104; P19096; Q6PB72; Q8C4Z0; Q9EQR0 | Fatty acid biosynthesis; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-9 fatty acid synthesis; Elongation of (very) long chain fatty acids | Fatty acyl-CoA biosynthesis; Vitamin B5 (pantothenate) metabolism | 0.66189768147619 | 0.847457711018997 | 0.951921622352553 | 0.605074788683686 | 0.994834213681465 | 0.746782404466558 | 0.990873516209569 | 102793.32580216101 | 1389784.0897720233 | 2729524.669883373 | 892753.3234074336 | 2995475.6339221266 | |
| Cont_Q3SZ57 | Alpha-fetoprotein OS=Bos taurus OX=9913 GN=AFP PE=2 SV=1 | 202.89 | 62 | 30 | 1153 | 29 | 610 | 68.5 | other metabolic processes;developmental processes;other biological processes | non-structural extracellular;other cell component | other molecular function | 506011 | ENSBTAG00000017131 | AFP | bta:506011; Q3SZ57 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 0.540832988168188 | 0.82964085881652 | 0.605387748357992 | 0.553772240900005 | 0.15729598575093 | 0.699570390946254 | 0.323545662226049 | 3.8603879197485335E7 | 4.5317948160280704E7 | 3.6151020512819335E7 | 3.679174310656657E7 | 4.2915740009991035E7 | ||
| P48678 | Prelamin-A/C [OS=Mus musculus] | 202.607 | 60 | 37 | 529 | 36 | 665 | 74.2 | cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes | other membranes;cytoskeleton;nucleus;other cell component | other molecular function | 16905 | ENSMUSG00000028063 | Lmna | B3RH23; B3RH24; mmu:16905; P11516; P48678; P97859; Q3TIH0; Q3TTS8; Q3U733; Q3U7I5; Q3UCA0; Q3UCJ8; Q3UCU3; Q91WF2; Q9DC21 | Adipogenesis genes; FAS pathway and stress induction of HSP regulation | 1.65082956259427E-17 | 0.00670345592293191 | 0.139423967594304 | 1.70336894001643E-17 | 0.77212820363828 | 0.901149690306505 | 0.00692305873191716 | 75722.11050192213 | 4134986.871037207 | 1.1058985470826533E7 | 6289356.16248022 | 5.369543399964929E7 | ||
| Q02788 | Collagen alpha-2(VI) chain [OS=Mus musculus] | 202.37 | 41 | 36 | 585 | 36 | 1034 | 110.3 | cell adhesion;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component | other molecular function | 12834 | ENSMUSG00000020241 | Col6a2 | mmu:12834; Q02788; Q05505; Q8C972; Q8K229 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | ECM proteoglycans; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation | 0.175734701097799 | 1.8644578313253E-17 | 0.633123216104285 | 0.767312384697355 | 0.880899056945259 | 0.0961283818482991 | 0.809503222445875 | 121237.29953889274 | 4.136492509189963E7 | 5.21291258166705E7 | 1.173163988850227E7 | 2.0595787144729633E7 | |
| P97927 | Laminin subunit alpha-4 [OS=Mus musculus] | 199.33 | 30 | 41 | 409 | 41 | 1816 | 201.7 | cell adhesion;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | signal transduction activity or receptor binding | 16775 | ENSMUSG00000019846 | Lama4 | mmu:16775; O88785; P70409; P97927; Q14BF2 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Formation of the dystrophin-glycoprotein complex (DGC); Laminin interactions; MET activates PTK2 signaling | 0.496649188935323 | 0.645007535999596 | 0.952104483873957 | 0.825047045401531 | 0.929291541980042 | 0.50594120050135 | 0.819844267712751 | 390078.69973194966 | 5125646.74812024 | 1.037511250312096E7 | 3065544.409694903 | 5760601.1965567535 | |
| P20152 | Vimentin [OS=Mus musculus] | 183.446 | 60 | 29 | 762 | 27 | 466 | 53.7 | cell organization and biogenesis;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component | cytoskeletal activity;nucleic acid binding activity;other molecular function | 22352 | ENSMUSG00000026728 | Vim | mmu:22352; O08704; P20152; Q8CCH1 | Spinal cord injury; Primary focal segmental glomerulosclerosis (FSGS); Alpha 6 beta 4 integrin signaling pathway | Aggrephagy; Striated Muscle Contraction; Caspase-mediated cleavage of cytoskeletal proteins; RHOBTB1 GTPase cycle | 1.65082956259427E-17 | 0.0955146622024883 | 1.50457038391225E-17 | 0.137621774180062 | 0.0297998664849654 | 0.840672080806375 | 0.0332723373064956 | 1112472.104030337 | 7365249.698992513 | 3.3401280645601466E7 | 1.292797841903164E7 | 7.464184195594883E7 | |
| Q64727 | Vinculin [OS=Mus musculus] | 182.753 | 50 | 45 | 419 | 45 | 1066 | 116.6 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | plasma membrane;other membranes;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 22330 | ENSMUSG00000021823 | Vcl | mmu:22330; Q64727; Q8BP32; Q8BS46; Q922C5; Q922D9 | Primary focal segmental glomerulosclerosis (FSGS); IL-3 signaling pathway; Regulation of actin cytoskeleton; Integrin-mediated cell adhesion; Focal adhesion | Neutrophil degranulation; High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells; Platelet degranulation ; MAP2K and MAPK activation; Smooth Muscle Contraction; Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells; Regulation of CDH1 Function | 0.208404050858596 | 0.190838415616571 | 0.238791978742132 | 0.504745711776551 | 0.878264980963866 | 0.977491813528386 | 0.958518237573655 | 126150.06188907423 | 1953982.7579073233 | 4840837.086136207 | 2359150.5810886133 | 6758257.200309387 | |
| Q8K4G1 | Latent-transforming growth factor beta-binding protein 4 [OS=Mus musculus] | 180.216 | 27 | 29 | 318 | 29 | 1666 | 178.5 | cell-cell signaling;cell organization and biogenesis;transport;signal transduction | non-structural extracellular;extracellular matrix | other molecular function | 108075 | ENSMUSG00000040488 | Ltbp4 | E9QPD9; mmu:108075; Q8K4G0; Q8K4G1 | TGF-beta receptor signaling activates SMADs; Molecules associated with elastic fibres | 0.308350896322176 | 0.362779483059131 | 1.50457038391225E-17 | 0.170566190602959 | 0.958956615096849 | 0.703189639676216 | 0.915193515309545 | 50068.58855747415 | 1469976.6770863 | 2473680.681365607 | 2657641.7444799202 | 7291299.088613093 | ||
| Q68FD5 | Clathrin heavy chain 1 [OS=Mus musculus] | 180.117 | 32 | 43 | 363 | 43 | 1675 | 191.4 | cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes | plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component | nucleic acid binding activity;other molecular function | 67300 | ENSMUSG00000047126 | Cltc | mmu:67300; Q68FD5 | IL-7 signaling pathway; Kit receptor signaling pathway | MHC class II antigen presentation; Recycling pathway of L1; Cargo recognition for clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis; LDL clearance; Retrograde neurotrophin signalling; Formation of annular gap junctions; Lysosome Vesicle Biogenesis; WNT5A-dependent internalization of FZD4; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation; RHOU GTPase cycle; RHOV GTPase cycle | 0.4248536990637 | 0.198232028950426 | 1.50457038391225E-17 | 0.413413145615294 | 0.840666598828607 | 0.946476383814868 | 0.835383236382767 | 14581.209031729499 | 1426606.2225329466 | 2101059.0869428 | 2078296.563295177 | 6830362.818457293 | |
| P02469 | Laminin subunit beta-1 [OS=Mus musculus] | 179.863 | 27 | 40 | 429 | 39 | 1786 | 197 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;nucleus;other cell component | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 16777 | ENSMUSG00000002900 | Lamb1 | E9PXZ9; P02469 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Inflammatory response pathway; Alpha 6 beta 4 integrin signaling pathway; Focal adhesion | 0.205801242418232 | 0.341417478664423 | 0.526489846375643 | 0.891178501081124 | 0.900334730044572 | 0.356773085915651 | 0.98779298590131 | 1.0460538665187027E7 | 1.4326337702720901E7 | 1.8407714250900764E7 | 2.1078383512013834E7 | 1.149610392953332E7 | ||
| Q01853 | Transitional endoplasmic reticulum ATPase [OS=Mus musculus] | 179.055 | 52 | 32 | 411 | 32 | 806 | 89.3 | cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;other biological processes | other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;enzyme regulator activity;other molecular function | 269523 | ENSMUSG00000028452 | Vcp | mmu:269523; Q01853; Q3TFH9; Q3TIM2; Q3TXN9; Q6PI18; Q8BSR6; Q8CEG4 | IL-9 signaling pathway | RHOH GTPase cycle; Neutrophil degranulation; Protein methylation; Ovarian tumor domain proteases; Neddylation; ABC-family proteins mediated transport; Translesion Synthesis by POLH; Hedgehog ligand biogenesis; KEAP1-NFE2L2 pathway; HSF1 activation; N-glycan trimming in the ER and Calnexin/Calreticulin cycle; Josephin domain DUBs | 0.915230778358139 | 0.645007535999596 | 0.808626104853287 | 0.953867932777128 | 0.877818946381645 | 0.901149690306505 | 0.737824045087029 | 621808.5300221853 | 5338414.413398174 | 9329554.935730066 | 4463650.11042755 | 1.2770955118061693E7 | |
| Q03350 | Thrombospondin-2 [OS=Mus musculus] | 178.303 | 35 | 30 | 328 | 29 | 1172 | 129.8 | cell adhesion;other biological processes | non-structural extracellular;extracellular matrix;other cell component | other molecular function | 21826 | ENSMUSG00000023885 | Thbs2 | mmu:21826; Q03350; Q8CG21 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Signaling by PDGF; O-glycosylation of TSR domain-containing proteins | 0.425958502904743 | 0.861805134687803 | 0.49027994509233 | 0.535702081245677 | 0.900334730044572 | 0.620448351319483 | 0.80954066750699 | 1929828.2171104867 | 7439397.130180354 | 1.1102887711296873E7 | 4211942.301314384 | 1.05864549049655E7 | |
| Q80YX1 | Tenascin [OS=Mus musculus] | 175.9 | 28 | 43 | 191 | 43 | 2110 | 231.7 | cell adhesion;cell-cell signaling;cell organization and biogenesis;stress response;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | signal transduction activity or receptor binding;other molecular function | 21923 | ENSMUSG00000028364 | Tnc | mmu:21923; Q64706; Q80YX1; Q80YX2 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Integrin cell surface interactions; ECM proteoglycans; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 0.117980756369098 | 0.827773046590747 | 0.560799429150649 | 0.474732236495646 | 0.00280630917527262 | 0.00972980877962454 | 0.46732263590517 | 20862.416559578665 | 1449614.4281484466 | 1.2106484504902953E7 | 96243.5238250637 | 211010.04547923067 | |
| Q61147 | Ceruloplasmin [OS=Mus musculus] | 175.43 | 36 | 33 | 380 | 33 | 1061 | 121.1 | cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular | other molecular function | 12870 | ENSMUSG00000003617 | Cp | mmu:12870; Q61147; Q6P5C8 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Iron uptake and transport; Metal ion SLC transporters | 1.65082956259427E-17 | 0.0286042496128814 | 0.232756100865398 | 0.470567140616547 | 0.902824569867946 | 0.217345018530886 | 0.830251457557488 | 116072.0240394514 | 4703216.257241024 | 9598922.193485493 | 1756646.5467629798 | 3587720.1567995367 | ||
| Q3UQ28 | Peroxidasin homolog [OS=Mus musculus] | 173.636 | 35 | 39 | 366 | 39 | 1475 | 165 | cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes | extracellular matrix;ER/Golgi;other cell component | extracellular structural activity;other molecular function | 69675 | ENSMUSG00000020674 | Pxdn | A4FU83; E9QNQ9; mmu:69675; Q3UQ28 | Crosslinking of collagen fibrils | 0.121749369203589 | 0.199060935853007 | 0.481687712882875 | 0.64860195920101 | 0.680311384167738 | 0.622521206052951 | 0.910753558746772 | 52188.79804577449 | 3468268.863888983 | 1.0141728842991263E7 | 1748064.7562207088 | 5865453.59009746 | ||
| Q61316 | Heat shock 70 kDa protein 4 [OS=Mus musculus] | 169.044 | 48 | 31 | 300 | 31 | 841 | 94.1 | protein metabolism;other metabolic processes | other cell component | other molecular function | Hspa4 | Q61316 | Regulation of HSF1-mediated heat shock response | 0.675982462193546 | 0.947627746595709 | 0.704651587991194 | 0.760498481134506 | 0.922660568001848 | 0.905946265571965 | 0.842404289073844 | 51496.56273693644 | 1715523.4149199834 | 3885769.0116153997 | 1450318.0074060035 | 4790126.20554149 | ||||
| Cont_P02533 | Keratin, type I cytoskeletal 14 OS=Homo sapiens OX=9606 GN=KRT14 PE=1 SV=4 | 164.831 | 58 | 26 | 684 | 9 | 472 | 51.5 | cell organization and biogenesis;other biological processes | plasma membrane;cytosol;cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 3861 | ENSG00000186847 | KRT14 | hsa:3861; P02533; Q14715; Q53XY3; Q9BUE3; Q9UBN2; Q9UBN3; Q9UCY4 | Corticotropin-releasing hormone signaling | Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin; Developmental Lineage of Mammary Gland Myoepithelial Cells; Type I hemidesmosome assembly | 0.821333803243143 | 0.880930298968675 | 0.666244110962191 | 0.887279041944908 | 0.728871118050286 | 0.645534074006669 | 1.76226512549596E-4 | 6829492.454091667 | 1.0299655985485494E7 | 9892865.41378706 | 2.9333304518974166E7 | 9460012.597296894 | |
| P11499 | Heat shock protein HSP 90-beta [OS=Mus musculus] | 164.719 | 50 | 29 | 532 | 19 | 724 | 83.2 | cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component | enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function | 15516 | ENSMUSG00000023944 | Hsp90ab1 | mmu:15516; O89078; P11499; Q3UIQ7 | Focal adhesion: PI3K-Akt-mTOR signaling pathway | Neutrophil degranulation; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of actin dynamics for phagocytic cup formation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Attenuation phase; Estrogen-dependent gene expression; Sema3A PAK dependent Axon repulsion; Aryl hydrocarbon receptor signalling; DDX58/IFIH1-mediated induction of interferon-alpha/beta; HSF1 activation; RHOBTB2 GTPase cycle; The NLRP3 inflammasome | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.385192173946943 | 0.975071223710592 | 0.476079393565723 | 166033.98771248801 | 1.0807613687705928E7 | 3.193268303009924E7 | 1.1608041082716169E7 | 4.22825068683512E7 | |
| Q9JKF1 | Ras GTPase-activating-like protein IQGAP1 [OS=Mus musculus] | 163.926 | 28 | 36 | 250 | 36 | 1657 | 188.6 | cell organization and biogenesis;developmental processes;signal transduction;other biological processes | plasma membrane;other membranes;cytoskeleton;nucleus;other cell component | enzyme regulator activity;other molecular function | 29875 | ENSMUSG00000030536 | Iqgap1 | G3UW45; mmu:29875; Q9JKF1 | G13 signaling pathway; Regulation of actin cytoskeleton | RHO GTPases activate IQGAPs; Neutrophil degranulation; RAC1 GTPase cycle; RAC2 GTPase cycle; RHOA GTPase cycle; MAP2K and MAPK activation; RHOQ GTPase cycle; RHOC GTPase cycle; RHOU GTPase cycle; RHOV GTPase cycle; Nephrin family interactions | 0.930229675308081 | 0.794460986683881 | 0.787568130909409 | 0.991639536226218 | 0.941920360687835 | 0.777195460870953 | 0.924682711624237 | 58984.367745696 | 331165.4406654323 | 1068898.0084058929 | 944145.2185002686 | 3795509.9873349466 | |
| P52480 | Pyruvate kinase PKM [OS=Mus musculus] | 163.393 | 62 | 27 | 442 | 27 | 531 | 57.8 | cell organization and biogenesis;other metabolic processes;other biological processes | cytosol;ER/Golgi;nucleus;other cell component | nucleic acid binding activity;kinase activity;other molecular function | 18746 | ENSMUSG00000032294 | Pkm | mmu:18746; P52480; Q3TBV8; Q3TBW5; Q3TC59; Q3U1X3; Q3U5P6; Q4VC20; Q64484; Q91YI8; Q9CWB1 | Glycolysis and gluconeogenesis; Purine metabolism | Neutrophil degranulation; Pyruvate metabolism; Glycolysis; Regulation of pyruvate metabolism | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.972868731003358 | 0.958705855138011 | 0.959522188921769 | 224031.9482756436 | 1.1706302394897154E7 | 1.6687028973496003E7 | 1.3595916090065738E7 | 3.1698865102110166E7 | |
| P63017 | Heat shock cognate 71 kDa protein [OS=Mus musculus] | 161.557 | 53 | 28 | 572 | 23 | 646 | 70.8 | cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component | signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function | 15481 | ENSMUSG00000015656 | Hspa8 | mmu:15481; P08109; P12225; P63017; Q3U6R0; Q3U764; Q3U7D7; Q3U7E2; Q3U9B4; Q3U9G0; Q3UGM0; Q5FWJ6; Q62373; Q62374; Q62375; Q6NZD0 | Mapk signaling pathway; Exercise-induced circadian regulation | Neutrophil degranulation; mRNA Splicing - Major Pathway; Regulation of HSF1-mediated heat shock response; PKR-mediated signaling; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis; Attenuation phase; Lysosome Vesicle Biogenesis; GABA synthesis, release, reuptake and degradation; AUF1 (hnRNP D0) binds and destabilizes mRNA; Protein methylation | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.953011140807089 | 0.709593139419252 | 0.587315224195015 | 232221.67704249235 | 1.5723480869725833E7 | 2.2348098618015703E7 | 1.2001189016638666E7 | 3.440867978172333E7 | |
| Q9JHU4 | Cytoplasmic dynein 1 heavy chain 1 [OS=Mus musculus] | 161.009 | 14 | 55 | 258 | 55 | 4644 | 531.7 | cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes | cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 13424 | ENSMUSG00000018707 | Dync1h1 | E9QM71; mmu:13424; Q9JHU4 | MHC class II antigen presentation; Neutrophil degranulation; Separation of Sister Chromatids; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; COPI-mediated anterograde transport; Recruitment of NuMA to mitotic centrosomes; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-independent Golgi-to-ER retrograde traffic; Aggrephagy; Anchoring of the basal body to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; AURKA Activation by TPX2 | 0.591873375996003 | 0.826895204418257 | 0.758743075163871 | 0.936818656936794 | 0.987352798667733 | 0.695927216301667 | 0.953305976192702 | 294620.0253220563 | 451351.8596347517 | 1275535.4534856554 | 1462326.6297541 | 5162177.518126 | ||
| Q99K41 | EMILIN-1 [OS=Mus musculus] | 157.011 | 31 | 21 | 244 | 21 | 1017 | 107.5 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 100952 | ENSMUSG00000029163 | Emilin1 | mmu:100952; Q99K41 | Molecules associated with elastic fibres | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.64186124184599 | 0.0921665663508908 | 0.491906845171331 | 1671715.86234765 | 5498413.09956387 | 384416.66366236034 | 2364922.89508055 | |||
| Q61879 | Myosin-10 [OS=Mus musculus] | 146 | 19 | 31 | 236 | 20 | 1976 | 228.9 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;nucleic acid binding activity;other molecular function | 77579 | ENSMUSG00000020900 | Myh10 | mmu:77579; Q5SV63; Q61879 | Regulation of actin cytoskeleton | RHO GTPases activate PAKs | 0.705689538076567 | 0.506231596289679 | 0.676239752697828 | 0.933545599871938 | 0.990096171400123 | 0.953146340313072 | 0.921444667457376 | 123378.89612673952 | 266023.60455562966 | 458865.269073755 | 562909.3462758837 | 1089526.38375758 | |
| Cont_P00761 | Trypsin OS=Sus scrofa OX=9823 PE=1 SV=1 | 143.502 | 62 | 11 | 3859 | 10 | 231 | 24.4 | protein metabolism;other biological processes | non-structural extracellular | other molecular function | 0.254996071775817 | 0.172153475402034 | 0.357784551188889 | 0.34040294575649 | 0.740968241512781 | 0.960577895552113 | 0.148582186670595 | 5.863252009900073E9 | 3.334729419178533E9 | 2.1792138371661735E9 | 4.479417756781787E9 | 2.35988129070601E9 | |||||||
| P20029 | Endoplasmic reticulum chaperone BiP [OS=Mus musculus] | 142.966 | 48 | 25 | 434 | 23 | 655 | 72.4 | protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component | enzyme regulator activity;translation activity;other molecular function | 14828 | ENSMUSG00000026864 | Hspa5 | mmu:14828; O35642; P20029; Q3UFF2; Q61630 | Mapk signaling pathway | Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Regulation of HSF1-mediated heat shock response | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.769590657123576 | 0.985707795620743 | 0.888702680095366 | 7392689.481756757 | 8222965.927916382 | 8403011.594768586 | 1.57890948929286E7 | ||
| Cont_P13647 | Keratin, type II cytoskeletal 5 OS=Homo sapiens OX=9606 GN=KRT5 PE=1 SV=3 | 142.395 | 51 | 34 | 500 | 20 | 590 | 62.3 | cell organization and biogenesis;other biological processes | cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;cytoskeletal activity;other molecular function | 3852 | ENSG00000186081 | KRT5 | hsa:3852; P13647; Q6PI71; Q6UBJ0; Q8TA91 | Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin; Developmental Lineage of Mammary Stem Cells; Developmental Lineage of Mammary Gland Myoepithelial Cells; Type I hemidesmosome assembly | 0.786915923361782 | 0.847457711018997 | 0.707170943024881 | 0.746833150482801 | 0.714156118974909 | 0.2733017775894 | 2.49132633766938E-5 | 5615099.536380176 | 7868513.182470503 | 9974982.226041706 | 2.8752414910160065E7 | 1.3998817771053001E7 | ||
| Cont_P08779 | Keratin, type I cytoskeletal 16 OS=Homo sapiens OX=9606 GN=KRT16 PE=1 SV=4 | 140.751 | 54 | 25 | 569 | 12 | 473 | 51.2 | cell organization and biogenesis;stress response;other biological processes | plasma membrane;cytosol;cytoskeleton | cytoskeletal activity | 3868 | ENSG00000186832 | KRT16 | A8K488; hsa:3868; P08779; P30654; Q16402; Q9UBG8 | Vitamin D receptor pathway | Formation of the cornified envelope | 0.941324060398065 | 0.961351301268194 | 0.761460393544015 | 0.887279041944908 | 0.493923182294169 | 0.895302208460818 | 3.1065941501805E-4 | 1275668.1444026066 | 3908256.3409277797 | 2249474.51763106 | 5401589.786976026 | 2569640.8216647534 | |
| Cont_P02465 | Collagen alpha-2(I) chain OS=Bos taurus OX=9913 GN=COL1A2 PE=1 SV=2 | 139.99 | 18 | 19 | 445 | 3 | 1364 | 129 | non-structural extracellular;extracellular matrix | extracellular structural activity;other molecular function | 282188 | ENSBTAG00000013472 | COL1A2 | A6QP13; bta:282188; O62649; P02465 | Inflammatory response pathway; Focal adhesion | Fibronectin matrix formation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Collagen degradation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; Collagen chain trimerization; GPVI-mediated activation cascade; Platelet Aggregation (Plug Formation); Platelet Adhesion to exposed collagen; GP1b-IX-V activation signalling | 0.483779141493222 | 0.876027096029978 | 0.421836754550416 | 0.488872343346086 | 0.076245756040016 | 0.549852418071669 | 0.432748651973214 | 70110.45197339094 | 85775.39066064726 | 163731.944383145 | 48702.045776696206 | 54970.44581499727 | ||
| Cont_P12763 | Alpha-2-HS-glycoprotein OS=Bos taurus OX=9913 GN=AHSG PE=1 SV=2 | 132.772 | 50 | 16 | 1191 | 16 | 359 | 38.4 | stress response;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component | enzyme regulator activity | 280988 | AHSG | A6QLF7; bta:280988; P12763 | Neutrophil degranulation; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 0.573667790345329 | 0.793013134473823 | 0.624272910267193 | 0.36488675645736 | 0.268930374946741 | 0.335956814949331 | 0.913214993335179 | 6.882384659684638E8 | 8.712402787486216E8 | 6.41500953397899E8 | 4.440672611032756E8 | 7.064361313920757E8 | |||
| P07901 | Heat shock protein HSP 90-alpha [OS=Mus musculus] | 132.382 | 43 | 25 | 402 | 16 | 733 | 84.7 | cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component | signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function | 15519 | ENSMUSG00000021270 | Hsp90aa1 | mmu:15519; P07901 | EBV LMP1 signaling; Focal adhesion: PI3K-Akt-mTOR signaling pathway; IL-6 signaling pathway; IL-2 signaling pathway | Regulation of necroptotic cell death; Recruitment of NuMA to mitotic centrosomes; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of actin dynamics for phagocytic cup formation; Neutrophil degranulation; Downregulation of ERBB2 signaling; Anchoring of the basal body to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; AURKA Activation by TPX2; Extra-nuclear estrogen signaling; Attenuation phase; Estrogen-dependent gene expression; Sema3A PAK dependent Axon repulsion; VEGFR2 mediated vascular permeability; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation; DDX58/IFIH1-mediated induction of interferon-alpha/beta; eNOS activation; HSF1 activation; RHOBTB2 GTPase cycle; Drug-mediated inhibition of ERBB2 signaling | 1.65082956259427E-17 | 0.508730894200713 | 1.50457038391225E-17 | 0.251664970734015 | 0.788764875934969 | 0.968364585136618 | 0.745600589176001 | 138049.65358917884 | 1667357.9717776468 | 3968795.71909318 | 1606774.576019598 | 6014683.841021903 | |
| Q02819 | Nucleobindin-1 [OS=Mus musculus] | 131.152 | 51 | 21 | 299 | 21 | 459 | 53.4 | signal transduction | non-structural extracellular;other membranes;ER/Golgi | enzyme regulator activity;nucleic acid binding activity;other molecular function | 18220 | ENSMUSG00000030824 | Nucb1 | mmu:18220; Q02819; Q3TU42; Q9CWA1; Q9D8J4; Q9DBL3 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 0.130903496983571 | 0.340647566778883 | 0.397987186613988 | 0.958122559708965 | 30635.69892492515 | 5493436.34719679 | 1.9240052036173E7 | 2379424.5332984333 | 6548209.148806977 | ||
| Q91V92 | ATP-citrate synthase [OS=Mus musculus] | 129.973 | 32 | 28 | 237 | 28 | 1091 | 119.7 | other metabolic processes | cytosol | other molecular function | 104112 | ENSMUSG00000020917 | Acly | mmu:104112; Q91V92 | Fatty acid biosynthesis | Neutrophil degranulation; Fatty acyl-CoA biosynthesis | 0.230775890814232 | 0.371468864113786 | 0.437429424171984 | 0.509570119936397 | 0.98558531112136 | 0.643183834410259 | 0.922580167429744 | 27537.414327710998 | 1276919.6113413726 | 2339759.4103227933 | 644183.8162072281 | 1777761.9344937534 | |
| A2ASQ1 | Agrin [OS=Mus musculus] | 128.989 | 18 | 26 | 227 | 26 | 1950 | 207.4 | cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cell component | signal transduction activity or receptor binding;other molecular function | 11603 | ENSMUSG00000041936 | Agrn | A2ASP9; A2ASQ0; A2ASQ1; B2RWU1 | Primary focal segmental glomerulosclerosis (FSGS) | ECM proteoglycans; Retinoid metabolism and transport; Glycosaminoglycan-protein linkage region biosynthesis; HS-GAG biosynthesis; HS-GAG degradation; Formation of the dystrophin-glycoprotein complex (DGC) | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.972791368602389 | 0.686318824668434 | 0.846971399004193 | 1695001.2322350666 | 3018900.06344302 | 1028829.4241236168 | 2045725.4701757336 | ||
| Q61508 | Extracellular matrix protein 1 [OS=Mus musculus] | 127.379 | 45 | 18 | 358 | 18 | 559 | 62.8 | stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular | signal transduction activity or receptor binding;other molecular function | 13601 | ENSMUSG00000028108 | Ecm1 | mmu:13601; Q3U5Q5; Q61508 | Platelet degranulation | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 0.121600547823456 | 0.795351011232032 | 1.51989274634622E-7 | 0.592370654746194 | 74811.39241511819 | 5.132626536679041E7 | 6.196550035866306E7 | 3515293.344106073 | 1.1331897286900917E7 | ||
| Cont_P04259 | Keratin, type II cytoskeletal 6B OS=Homo sapiens OX=9606 GN=KRT6B PE=1 SV=5 | 126.901 | 47 | 30 | 442 | 4 | 564 | 60 | cell organization and biogenesis;other biological processes | cytosol;cytoskeleton | bone, tooth or skin structural activity;cytoskeletal activity | 3854 | ENSG00000185479 | KRT6B | hsa:3854; P04259; P48669 | Formation of the cornified envelope | 0.857251372850113 | 0.868132360832926 | 0.758743075163871 | 0.801271130817871 | 0.340133476321195 | 0.937453377971347 | 0.00123883404563536 | 298970.1410949 | 1156058.5455969477 | 510017.07482617133 | 1115770.6869766254 | 854901.7358096777 | ||
| P17182 | Alpha-enolase [OS=Mus musculus] | 126.804 | 60 | 19 | 244 | 16 | 434 | 47.1 | other metabolic processes;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;other cell component | nucleic acid binding activity;other molecular function | 13806; 433182 | ENSMUSG00000059040; ENSMUSG00000063524 | Eno1 | mmu:13806; mmu:433182; P17182; Q99KT7; Q9DCY7 | Glycolysis and gluconeogenesis | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.789540446904924 | 0.858218537342417 | 0.989544231571828 | 47358.53377381337 | 9473047.660860082 | 1.1146559483992001E7 | 1.3905788568310633E7 | 2.89416009584274E7 | ||
| P08113 | Endoplasmin [OS=Mus musculus] | 126.346 | 39 | 26 | 329 | 25 | 802 | 92.4 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cell component | signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function | 22027 | ENSMUSG00000020048 | Hsp90b1 | mmu:22027; P08113; P11427 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Hypoxia-dependent self-renewal of myoblasts | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Scavenging by Class A Receptors; Trafficking and processing of endosomal TLR; Interleukin-4 and Interleukin-13 signaling | 0.107476768049312 | 0.0104456807471941 | 1.50457038391225E-17 | 0.205304099107124 | 0.840785133352029 | 0.866766165039268 | 0.896996950298791 | 52582.03853978356 | 4030450.84914005 | 5006439.15200075 | 6037105.20140975 | 1.2434595462188734E7 | |
| P58252 | Elongation factor 2 [OS=Mus musculus] | 126.048 | 37 | 31 | 378 | 30 | 858 | 95.3 | cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;translational apparatus;other cell component | cytoskeletal activity;translation activity;nucleic acid binding activity;other molecular function | 13629 | ENSMUSG00000034994 | Eef2 | mmu:13629; P58252; Q544E4 | Translation factors | Neutrophil degranulation; Protein methylation; Peptide chain elongation; Synthesis of diphthamide-EEF2 | 0.299809054080284 | 0.188334321166369 | 0.471929633209224 | 0.84258396038376 | 0.97504218639442 | 0.866546043492515 | 0.950878070645738 | 229633.38558146535 | 6414138.274151959 | 1.0566307796994643E7 | 4859646.5618234025 | 1.3065706600835832E7 | |
| Cont_P02538 | Keratin, type II cytoskeletal 6A OS=Homo sapiens OX=9606 GN=KRT6A PE=1 SV=3 | 123.757 | 47 | 30 | 454 | 3 | 564 | 60 | cell organization and biogenesis;stress response;other biological processes | cytosol;cytoskeleton | bone, tooth or skin structural activity;cytoskeletal activity | 3853 | ENSG00000205420 | KRT6A | A4QPC1; hsa:3853; P02538; P48667; Q08AR4; Q6NT67; Q96CL4 | Ectoderm differentiation; Ectoderm differentiation; Pancreatic cancer subtypes | Formation of the cornified envelope | 0.892533464536408 | 0.964633336683333 | 0.745886066139481 | 0.84258396038376 | 0.574739141583974 | 0.709593139419252 | 5.66461038960431E-4 | 2182876.549653717 | 4785085.111074816 | 3779160.7730984767 | 8485501.699692694 | 3982846.61307857 | |
| P97298 | Pigment epithelium-derived factor [OS=Mus musculus] | 123.502 | 47 | 16 | 346 | 12 | 417 | 46.2 | cell cycle OR cell proliferation;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | enzyme regulator activity | 20317 | ENSMUSG00000000753 | Serpinf1 | mmu:20317; O70629; O88691; P97298 | 1.65082956259427E-17 | 0.227296093012204 | 0.434748506750565 | 0.770205086382264 | 0.174886032348437 | 0.300753028734261 | 0.891044455497809 | 462579.17347644636 | 1.46490289953418E7 | 7.121805491857927E7 | 5921015.69252881 | 1.5757205380580032E7 | |||
| Q70E20 | Sushi, nidogen and EGF-like domain-containing protein 1 [OS=Mus musculus] | 122.942 | 19 | 22 | 287 | 22 | 1403 | 151.5 | cell adhesion | non-structural extracellular;extracellular matrix | other molecular function | 208777 | Sned1 | A6H6I3; mmu:208777; Q70E20; Q810H2; Q8BMD9 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.869908412860824 | 0.817293288705596 | 0.880760468933162 | 37861.533059704365 | 3293936.3484006864 | 6267209.5561869135 | 4995161.517920501 | 1.4223395042125002E7 | ||||
| P13020 | Gelsolin [OS=Mus musculus] | 122.934 | 35 | 22 | 377 | 9 | 780 | 85.9 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 227753 | ENSMUSG00000026879 | Gsn | mmu:227753; P13020; Q3UPB1; Q8R590 | Regulation of actin cytoskeleton | Neutrophil degranulation; Caspase-mediated cleavage of cytoskeletal proteins | 0.440427841758307 | 0.396306424610341 | 0.186266168629733 | 0.379422692457324 | 0.994546642862744 | 0.709593139419252 | 0.793590033024783 | 1139775.9088509877 | 6438031.44422588 | 9825643.045518672 | 1.1033925013460701E7 | 2.9144067496602204E7 | |
| Q61398 | Procollagen C-endopeptidase enhancer 1 [OS=Mus musculus] | 120.4 | 40 | 14 | 323 | 14 | 468 | 50.1 | protein metabolism;other biological processes | enzyme regulator activity;other molecular function | 18542 | ENSMUSG00000029718 | Pcolce | mmu:18542; O35113; Q61398 | mRNA processing | Collagen biosynthesis and modifying enzymes; Crosslinking of collagen fibrils | 1.65082956259427E-17 | 1.8644578313253E-17 | 0.151224536345852 | 0.288320039261486 | 0.789540446904924 | 0.0895861566882082 | 0.711902858921665 | 84503.2651712337 | 2.52047208020085E7 | 2.958750643636163E7 | 7672570.19904635 | 1.2538308810459368E7 | ||
| P26039 | Talin-1 [OS=Mus musculus] | 118.226 | 15 | 30 | 153 | 30 | 2541 | 269.7 | cell adhesion;cell organization and biogenesis;signal transduction | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;other molecular function | 21894 | ENSMUSG00000028465 | Tln1 | A2AIM8; mmu:21894; P26039; Q8VEF0 | Primary focal segmental glomerulosclerosis (FSGS); Integrin-mediated cell adhesion; Focal adhesion | Platelet degranulation ; MAP2K and MAPK activation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; Smooth Muscle Contraction; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 0.958262397335385 | 0.994542145304377 | 0.680632778351053 | 0.738983404380581 | 0.783910800136359 | 0.87222702623065 | 0.535066779633529 | 147890.2697082064 | 165904.24421521465 | 567933.664164035 | 286851.2614141297 | 2291518.0404973766 | |
| Q8BPB5 | EGF-containing fibulin-like extracellular matrix protein 1 [OS=Mus musculus] | 117.738 | 49 | 15 | 220 | 15 | 493 | 54.9 | protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes | extracellular matrix | signal transduction activity or receptor binding;kinase activity;other molecular function | 216616 | ENSMUSG00000020467 | Efemp1 | mmu:216616; Q6Y3N6; Q8BPB5 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 0.376780684027729 | 0.983440558239231 | 0.145805028390539 | 0.982581944728745 | 29995.485006469138 | 4441372.613318663 | 7007290.288389671 | 1370373.3251651835 | 3606517.1409647237 | |||
| P09411 | Phosphoglycerate kinase 1 [OS=Mus musculus] | 116.462 | 57 | 18 | 287 | 18 | 417 | 44.5 | protein metabolism;other metabolic processes;stress response;other biological processes | non-structural extracellular;other membranes;cytosol;mitochondrion;other cell component | kinase activity;other molecular function | 18655 | ENSMUSG00000062070 | Pgk1 | mmu:18655; P09411; Q3TPE6; Q3UKV8; Q5XJE7 | Glycolysis and gluconeogenesis | Gluconeogenesis; Glycolysis | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.766862952867809 | 0.820281310709571 | 0.891044455497809 | 46750.53578358531 | 3210948.6178334034 | 3594147.655304653 | 4500077.619792943 | 1.4795712145397767E7 | |
| P27773 | Protein disulfide-isomerase A3 [OS=Mus musculus] | 115.891 | 55 | 23 | 291 | 23 | 505 | 56.6 | cell adhesion;cell organization and biogenesis;stress response;signal transduction;other biological processes | non-structural extracellular;other membranes;ER/Golgi;other cell component | nucleic acid binding activity;other molecular function | 14827 | ENSMUSG00000027248 | Pdia3 | mmu:14827; P27773; Q3TEI9; Q3TIL2; Q3UZK8; Q8C2F4; Q99LF6 | ER-Phagosome pathway; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Calnexin/calreticulin cycle | 0.9135584231482 | 0.736536116100563 | 0.498293621965442 | 0.874168055361729 | 0.862063111456553 | 0.881496352314601 | 0.939046770372612 | 196243.61956605766 | 5161827.016313557 | 6480316.532156386 | 7238345.98431998 | 1.5315044241817234E7 | ||
| P10107 | Annexin A1 [OS=Mus musculus] | 115.566 | 64 | 18 | 270 | 18 | 346 | 38.7 | cell organization and biogenesis;stress response;transport;signal transduction;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component | enzyme regulator activity;other molecular function | 16952 | ENSMUSG00000024659 | Anxa1 | mmu:16952; P10107 | Spinal cord injury; Prostaglandin synthesis and regulation | G alpha (q) signalling events; G alpha (i) signalling events; Formyl peptide receptors bind formyl peptides and many other ligands | 1.65082956259427E-17 | 0.105053536950499 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.401885831342676 | 0.529099828181544 | 0.924766494197286 | 8983.410658903753 | 1675870.316312303 | 6017153.19339518 | 4211649.667813237 | 1.08370832078509E7 | |
| Cont_Q2KJF1 | Alpha-1B-glycoprotein OS=Bos taurus OX=9913 GN=A1BG PE=1 SV=1 | 115.502 | 48 | 14 | 224 | 14 | 503 | 53.5 | signal transduction | non-structural extracellular;plasma membrane;other membranes | 518955 | A1BG | bta:518955; Q2KJF1 | Platelet degranulation ; Neutrophil degranulation | 0.635218461842139 | 0.655487072215252 | 0.641514600397631 | 0.360991986803736 | 0.696358249006924 | 0.601376052147163 | 0.891044455497809 | 9385194.584847162 | 9820849.23751892 | 8859077.038578315 | 6762503.63408608 | 1.0317459698123023E7 | ||||
| Cont_Q3MHN5 | Vitamin D-binding protein OS=Bos taurus OX=9913 GN=GC PE=2 SV=1 | 113.599 | 55 | 20 | 319 | 20 | 474 | 53.3 | other metabolic processes;transport | non-structural extracellular;other cell component | transporter activity;cytoskeletal activity;other molecular function | 530076 | GC | bta:530076; Q3MHN5 | 0.549057967251154 | 0.804331105646976 | 0.579435037816218 | 0.479472599858427 | 0.139718417146003 | 0.570795727084329 | 0.421365656927814 | 1.2784681703575822E7 | 1.5974245944817802E7 | 1.026921939097026E7 | 1.0785165311962552E7 | 1.4618596373270534E7 | ||||
| P17742 | Peptidyl-prolyl cis-trans isomerase A [OS=Mus musculus] | 113.527 | 60 | 9 | 369 | 9 | 164 | 18 | cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes | non-structural extracellular;cytosol;nucleus;other cell component | signal transduction activity or receptor binding;other molecular function | 268373 | ENSMUSG00000071866 | Ppia | mmu:268373; P17742; Q9CWJ5; Q9R137 | Neutrophil degranulation; Basigin interactions | 0.100219677394751 | 0.099382125133403 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.696358249006924 | 0.937453377971347 | 0.331144967260478 | 5533917.143041036 | 1.0145464905716315E7 | 3.610988970082183E7 | 1.0696784170781441E7 | 4.607074026803666E7 | ||
| Q69ZN7 | Myoferlin [OS=Mus musculus] | 112.647 | 22 | 36 | 227 | 36 | 2048 | 233.2 | cell organization and biogenesis;other metabolic processes;stress response;other biological processes | plasma membrane;other membranes;nucleus | other molecular function | 226101 | ENSMUSG00000048612 | Myof | mmu:226101; Q69ZN7; Q7TMG0; Q80V33; Q8BU64; Q8BU70; Q8BUC1; Q8BVY6; Q8C0D1; Q8R3B4 | 0.73657372909066 | 0.964709887217926 | 0.888974672311279 | 0.930955411749965 | 0.877818946381645 | 0.609903091678244 | 0.975029032316037 | 74563.786625436 | 322363.41862436634 | 911704.7850761963 | 1104935.9693987637 | 3065805.015040973 | |||
| P26041 | Moesin [OS=Mus musculus] | 112.068 | 47 | 28 | 353 | 19 | 577 | 67.7 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function | 17698 | ENSMUSG00000031207 | Msn | B1AX70; mmu:17698; P26041; Q3UL28; Q8BSN4 | Regulation of actin cytoskeleton | Recycling pathway of L1 | 1.65082956259427E-17 | 0.0604972675946614 | 1.50457038391225E-17 | 0.157138696252226 | 0.682171843898269 | 0.97925982662951 | 0.954396180425051 | 3564499.916018247 | 9136364.2843242 | 1.7052591672350097E7 | 1.120013397828275E7 | 1.9030746620886367E7 | |
| P05064 | Fructose-bisphosphate aldolase A [OS=Mus musculus] | 112.015 | 66 | 18 | 261 | 18 | 364 | 39.3 | cell organization and biogenesis;other metabolic processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | other molecular function | 11674 | ENSMUSG00000030695 | Aldoa | mmu:11674; P05064 | Glycolysis and gluconeogenesis | Platelet degranulation ; Neutrophil degranulation; Gluconeogenesis; Glycolysis | 0.101571037453114 | 0.00616383846364181 | 1.50457038391225E-17 | 0.0771819601934254 | 0.828577692034317 | 0.988377544628277 | 0.953305976192702 | 21908.055682018665 | 4319055.57861477 | 4893427.94836492 | 4518789.603964283 | 1.0653934694757948E7 | |
| B2RQC6 | Multifunctional protein CAD [OS=Mus musculus] | 111.853 | 18 | 32 | 111 | 32 | 2225 | 243.1 | other metabolic processes;stress response;transport;developmental processes;other biological processes | cytosol;nucleus;other cell component | kinase activity;other molecular function | 69719 | ENSMUSG00000013629 | Cad | B2RQC6; B7ZN27; mmu:69719 | Mechanisms associated with pluripotency | Pyrimidine biosynthesis | 0.69394578118832 | 0.6681512188534 | 0.666244110962191 | 0.963127218853016 | 0.968897093792999 | 0.798180783050573 | 0.621633895543644 | 34439.61575478624 | 448793.6641228067 | 957747.5456383955 | 139659.55402474166 | 452794.3373622177 | |
| Q8BND5 | Sulfhydryl oxidase 1 [OS=Mus musculus] | 111.186 | 35 | 22 | 242 | 22 | 748 | 82.7 | cell organization and biogenesis;other biological processes | non-structural extracellular;other membranes;ER/Golgi | other molecular function | 104009 | ENSMUSG00000033684 | Qsox1 | mmu:104009; Q3TDY9; Q3TE19; Q3TR29; Q3UEL4; Q8BND5; Q8K041; Q9DBL6 | Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Neutrophil degranulation | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 0.162753188077458 | 0.696358249006924 | 0.331332346840573 | 0.877612009404373 | 25068.200750320597 | 3849451.1157268733 | 1.052758137572049E7 | 1818282.5759143168 | 5040172.36278756 |
A
B
C
D
E
F
G
H
I
J
K
L
M
N
O
P
Q
R
S
T
U
V
W
X
Y
Z
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
| Accession | Description | Sum PEP Score | Biological Process | Cellular Component | Molecular Function | Entrez Gene ID | Ensembl Gene ID | Gene Symbol | Gene ID | WikiPathways | Reactome Pathways | Abundance Ratio Adj. P-Value: (LQ_6h) / (FM_control) | Abundance Ratio Adj. P-Value: (LQ_16h) / (FM_control) | FM_AVERAGE | LQ6h_AVERAGE | LQ16h_AVERAGE | FC_ LQ6h vs NC | FC_ LQ16h vs FM | |||||||
| P11276 | Fibronectin [OS=Mus musculus] | 867.353 | cell adhesion;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi | signal transduction activity or receptor binding;enzyme regulator activity;other molecular function | 14268 | ENSMUSG00000026193 | Fn1 | G5E8B8; mmu:14268; P11276; Q61567; Q61568; Q61569; Q64233; Q80UI4 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Inflammatory response pathway; Regulation of actin cytoskeleton; Comprehensive IL-17A signaling; Focal adhesion | ECM proteoglycans; Platelet degranulation ; Cell surface interactions at the vascular wall; Syndecan interactions; MAP2K and MAPK activation; Integrin cell surface interactions; Molecules associated with elastic fibres; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Fibronectin matrix formation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; Degradation of the extracellular matrix; Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells; MET activates PTK2 signaling; GPER1 signaling | 0.00584906503121538 | 0.0844744457809114 | 2.76414533778046E7 | 2.022341523870097E8 | 2.12696235413058E8 | 2.8711212743884964 | 2.9438891195215318 | |||||||
| P11087 | Collagen alpha-1(I) chain [OS=Mus musculus] | 797.017 | cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12842 | ENSMUSG00000001506 | Col1a1 | mmu:12842; P11087; Q53WT0; Q60635; Q61367; Q61427; Q63919; Q6PCL3; Q810J9 | Osteoblast signaling; Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Comprehensive IL-17A signaling; Focal adhesion | Cell surface interactions at the vascular wall; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ECM proteoglycans; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; GPVI-mediated activation cascade; GP1b-IX-V activation signalling; Platelet Adhesion to exposed collagen; Platelet Aggregation (Plug Formation); MET activates PTK2 signaling | 1.8644578313253E-17 | 1.65082956259427E-17 | 772438.0834537543 | 2.0798706453114033E8 | 5.92854376184685E8 | 8.07285879426701 | 9.58404276622316 | |||||||
| Q01149 | Collagen alpha-2(I) chain [OS=Mus musculus] | 773.662 | cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12843 | ENSMUSG00000029661 | Col1a2 | mmu:12843; Q01149; Q8CGA5 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Focal adhesion | Crosslinking of collagen fibrils; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; ECM proteoglycans; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; GPVI-mediated activation cascade; GP1b-IX-V activation signalling; Platelet Adhesion to exposed collagen; Platelet Aggregation (Plug Formation); MET activates PTK2 signaling | 1.8644578313253E-17 | 1.65082956259427E-17 | 182180.3275564673 | 1.7308392932505235E8 | 3.475967473053053E8 | 9.891888882254342 | 10.89783168612198 | |||||||
| P08121 | Collagen alpha-1(III) chain [OS=Mus musculus] | 695.631 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | extracellular matrix;other cell component | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 12825 | ENSMUSG00000026043 | Col3a1 | mmu:12825; P08121; Q61429; Q9CRN7 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Focal adhesion | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ECM proteoglycans; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; MET activates PTK2 signaling | 1.8644578313253E-17 | 1.65082956259427E-17 | 454748.1180174556 | 6.282890624937943E7 | 2.8394661715058166E8 | 7.110216987795516 | 9.286336341446717 | |||||||
| Q9QXS1 | Plectin [OS=Mus musculus] | 659.702 | cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component | cytoskeletal activity;other molecular function | 18810 | ENSMUSG00000022565 | Plec | E9QN87; mmu:18810; Q6S384; Q6S389; Q6S394; Q9CS65; Q9QUT2; Q9QXQ8; Q9QXQ9; Q9QXR0; Q9QXR1; Q9QXR2; Q9QXR3; Q9QXR4; Q9QXR5; Q9QXR6; Q9QXR7; Q9QXR8; Q9QXR9; Q9QXS0; Q9QXS1; Q9QXS2; Q9QXS3 | Alpha 6 beta 4 integrin signaling pathway; EGFR1 signaling pathway | Type I hemidesmosome assembly; Caspase-mediated cleavage of cytoskeletal proteins | 0.714932595871944 | 0.481729871164266 | 309922.514176982 | 4599273.114185064 | 1.6676006673579365E7 | 3.891426402670929 | 5.749722481744953 | |||||||
| P08122 | Collagen alpha-2(IV) chain [OS=Mus musculus] | 526.992 | RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix | extracellular structural activity | 12827 | ENSMUSG00000031503 | Col4a2 | mmu:12827; P08122; Q3B7C2; Q3TPV9; Q61375; Q66JS5; Q6RCT6; Q6RCT7; Q6U9X1; Q8BPI9; Q8BPK3; Q91VI3 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Focal adhesion | Laminin interactions; Signaling by PDGF; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions | 0.64759425713406 | 0.352816378116182 | 1393534.8123072747 | 1.3981747232493034E7 | 5.0194805286054574E7 | 3.3267237103227703 | 5.170717117454539 | |||||||
| Q3U962 | Collagen alpha-2(V) chain [OS=Mus musculus] | 518.514 | cell organization and biogenesis;developmental processes;other biological processes | extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12832 | ENSMUSG00000026042 | Col5a2 | mmu:12832; Q3TVR2; Q3U962; Q3UHK7; Q3UTT4; Q3V1J6; Q61431; Q7TMS0; Q80VS8 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions | 0.961254912149485 | 0.861384746267066 | 2.4419841082594533E7 | 1.5753424919239333E7 | 4.592471970087584E7 | -0.6323882956741324 | 0.9112171042444063 | |||||||
| Q05793 | Basement membrane-specific heparan sulfate proteoglycan core protein [OS=Mus musculus] | 507.28 | cell organization and biogenesis;transport;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;ER/Golgi | other molecular function | 15530 | Hspg2 | mmu:15530; Q05793 | 0.382764581022518 | 0.332090710292395 | 171009.25706548532 | 2.1355561683383033E7 | 4.109385814368304E7 | 6.964393610173966 | 7.908704552577742 | ||||||||||
| Q61554 | Fibrillin-1 [OS=Mus musculus] | 499.202 | cell adhesion;other metabolic processes;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 14118 | ENSMUSG00000027204 | Fbn1 | A2AQ53; mmu:14118; Q60826; Q61554 | Comprehensive IL-17A signaling | Integrin cell surface interactions; Degradation of the extracellular matrix; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; TGF-beta receptor signaling activates SMADs; Molecules associated with elastic fibres | 0.0840496117897429 | 0.0596853092747711 | 81731.837224874 | 2.17735814942991E7 | 5.216417896597137E7 | 8.057464853046588 | 9.317945570971949 | |||||||
| Q8BTM8 | Filamin-A [OS=Mus musculus] | 493.069 | cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;other molecular function | 192176 | ENSMUSG00000031328 | Flna | B7FAV0; O54934; Q7TQI1; Q8BLK1; Q8BTM8; Q8BTN7; Q8VHX5; Q8VHX8; Q99KQ2 | Mapk signaling pathway; Focal adhesion | Platelet degranulation ; Cell-extracellular matrix interactions; RHO GTPases activate PAKs; GP1b-IX-V activation signalling | 0.493514006575528 | 0.0844935092512095 | 218480.8558628913 | 4952287.405198824 | 1.1395384793048913E7 | 4.502516267694667 | 5.704798960580473 | |||||||
| P02463 | Collagen alpha-1(IV) chain [OS=Mus musculus] | 487.707 | cell organization and biogenesis;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix | extracellular structural activity;other molecular function | 12826 | ENSMUSG00000031502 | Col4a1 | mmu:12826; P02463; Q3UHJ4; Q3UJE7; Q3UQV2; Q53X35; Q6GQS7; Q6PHB5; Q99LQ8 | Spinal cord injury; Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Laminin interactions; Signaling by PDGF; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions | 0.68008321917751 | 0.604225174343649 | 262271.417553364 | 4620515.057112186 | 2.1463797748519864E7 | 4.138921184627833 | 6.3547009644888925 | |||||||
| Q60847 | Collagen alpha-1(XII) chain [OS=Mus musculus] | 480.266 | cell adhesion;developmental processes | other cell component | 12816 | ENSMUSG00000032332 | Col12a1 | mmu:12816; P70322; Q60847 | Assembly of collagen fibrils and other multimeric structures; Collagen chain trimerization; Collagen degradation | 1.8644578313253E-17 | 0.0975092237649803 | 80180.17821443231 | 5.1736330625803865E7 | 2.9952489655588504E7 | 9.33371639573238 | 8.545214585562245 | |||||||||
| Q8VDD5 | Myosin-9 [OS=Mus musculus] | 418.364 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;stress response;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;other molecular function | 17886 | ENSMUSG00000022443 | Myh9 | mmu:17886; Q3UHT9; Q3UHU4; Q6KAN6; Q811I2; Q8VDD5 | Primary focal segmental glomerulosclerosis (FSGS) | RHO GTPases activate PAKs; Regulation of actin dynamics for phagocytic cup formation | 0.0382609387499984 | 0.156498497144098 | 100319.6147091511 | 5176534.940650649 | 8067345.413832072 | 5.68931109493806 | 6.32941841059592 | |||||||
| Cont_P02453 | Collagen alpha-1(I) chain OS=Bos taurus OX=9913 GN=COL1A1 PE=1 SV=3 | 414.689 | cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | 282187 | ENSBTAG00000013103 | COL1A1 | bta:282187; P02453; Q3MHM2 | Inflammatory response pathway; Osteoblast signaling; Focal adhesion | Fibronectin matrix formation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Collagen degradation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; Collagen chain trimerization; GPVI-mediated activation cascade; Platelet Aggregation (Plug Formation); Platelet Adhesion to exposed collagen; GP1b-IX-V activation signalling | 0.579410556046386 | 0.800889767710788 | 228542.54091026666 | 3262486.7198886867 | 3910059.36528234 | 3.8354373904758865 | 4.096655873055708 | |||||||
| Cont_P02769 | Albumin OS=Bos taurus OX=9913 GN=ALB PE=1 SV=4 | 390.555 | stress response;other biological processes | non-structural extracellular;other cell component | nucleic acid binding activity;other molecular function | 280717 | ALB | A5PJX3; bta:280717; O02787; P02769; P04277; Q3SZR2 | 0.650544967914241 | 0.520832629933248 | 2.7142766432154403E9 | 2.9099571807541137E9 | 2.4034772237737E9 | 0.10043015448628909 | -0.17544463789319698 | ||||||||||
| P01027 | Complement C3 [OS=Mus musculus] | 388.541 | cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular;other cell component | signal transduction activity or receptor binding;enzyme regulator activity | 12266 | ENSMUSG00000024164 | C3 | mmu:12266; P01027; Q61370; Q80XP1 | Complement activation, classical pathway; Tyrobp causal network in microglia; Comprehensive IL-17A signaling | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade; Neutrophil degranulation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; G alpha (i) signalling events; Peptide ligand-binding receptors; Alternative complement activation; Activation of C3 and C5 | 0.729783028721347 | 0.712660037675161 | 3269916.660849947 | 1.6657146132333001E7 | 4.4549110086954266E7 | 2.348815473163776 | 3.7680708408856756 | |||||||
| Cont_Q7SIH1 | Alpha-2-macroglobulin OS=Bos taurus OX=9913 GN=A2M PE=1 SV=2 | 370.864 | non-structural extracellular | enzyme regulator activity;other molecular function | 513856 | ENSBTAG00000018137 | A2M | A8E647; bta:513856; Q7SIH1 | IL-6 signaling pathway | 0.839052280267302 | 0.688450665125024 | 5.423624331449187E7 | 7.564994624258716E7 | 7.018676700369896E7 | 0.48008180391196364 | 0.37194179744919537 | |||||||||
| Cont_Q29443 | Serotransferrin OS=Bos taurus OX=9913 GN=TF PE=2 SV=1 | 343.183 | stress response;transport;other biological processes | non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle | other molecular function | 280705 | TF | bta:280705; Q0IIK2; Q29443 | 0.964709887217926 | 0.615274986253429 | 1.48932090998098E8 | 2.32106703986673E8 | 1.5606409762411097E8 | 0.6401335422147162 | 0.06748403432742182 | ||||||||||
| Cont_P07589 | Fibronectin OS=Bos taurus OX=9913 GN=FN1 PE=1 SV=4 | 337.517 | cell adhesion;cell organization and biogenesis;stress response;developmental processes;other biological processes | non-structural extracellular | signal transduction activity or receptor binding;other molecular function | FN1 | P07589 | 0.525827426782658 | 0.714071857030863 | 166255.75410196633 | 835883.8306505851 | 952169.9232567847 | 2.329898180493011 | 2.5178147853003274 | |||||||||||
| Q80X90 | Filamin-B [OS=Mus musculus] | 335.882 | cell organization and biogenesis;stress response;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 286940 | ENSMUSG00000025278 | Flnb | E9QNV9; mmu:286940; Q80X90; Q8VHX4; Q8VHX7; Q99KY3 | ISG15 antiviral mechanism | 0.238365792894698 | 0.296944306247309 | 154624.23024854946 | 2351112.5534752235 | 6048828.490809467 | 3.926505287666639 | 5.289817436625841 | ||||||||
| Cont_P35527 | Keratin, type I cytoskeletal 9 OS=Homo sapiens OX=9606 GN=KRT9 PE=1 SV=3 | 310.424 | cell organization and biogenesis;other biological processes | cytosol;cytoskeleton | cytoskeletal activity | 3857 | ENSG00000171403 | KRT9 | hsa:3857; O00109; P35527; Q0IJ47; Q14665 | Formation of the cornified envelope | 0.73072258897653 | 0.836660982916281 | 2.9224080803851068E7 | 3.250630567014273E7 | 4.1318104811136335E7 | 0.1535619557424608 | 0.4996164340004211 | ||||||||
| Cont_P04264 | Keratin, type II cytoskeletal 1 OS=Homo sapiens OX=9606 GN=KRT1 PE=1 SV=6 | 306.58 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;other molecular function | 3848 | ENSG00000167768 | KRT1 | B2RA01; hsa:3848; P04264; P85925; P86104; Q14720; Q6GSJ0; Q9H298 | Corticotropin-releasing hormone signaling | Formation of the cornified envelope; Neutrophil degranulation; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.653826967689551 | 0.65780924735352 | 1.5397854514739665E8 | 1.3414412508194733E8 | 1.6528138436319932E8 | -0.1989454723145774 | 0.10219489843707631 | |||||||
| P06909 | Complement factor H [OS=Mus musculus] | 292.01 | cell adhesion;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes | non-structural extracellular;plasma membrane;other membranes;mitochondrion;other cell component | other molecular function | 12628 | ENSMUSG00000026365 | Cfh | mmu:12628; P06909; Q6NZK3 | Regulation of Complement cascade | 0.0359547312524068 | 0.205200089226065 | 59542.32714759521 | 1.0566840244224759E7 | 1.036081717107911E7 | 7.471412714259086 | 7.443006470545328 | ||||||||
| P16546 | Spectrin alpha chain, non-erythrocytic 1 [OS=Mus musculus] | 291.854 | cell organization and biogenesis | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 20740 | ENSMUSG00000057738 | Sptan1 | A3KGU6; A3KGU8; P16546; Q8K380; Q9CT05 | FAS pathway and stress induction of HSP regulation | Neutrophil degranulation; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Interaction between L1 and Ankyrins; COPI-mediated anterograde transport; RHOU GTPase cycle; RHOV GTPase cycle; Caspase-mediated cleavage of cytoskeletal proteins | 0.786160319109602 | 0.958962194559628 | 684626.7741473566 | 1427277.73205798 | 3976922.979229001 | 1.0598764752393854 | 2.5382630028634425 | |||||||
| Cont_P13645 | Keratin, type I cytoskeletal 10 OS=Homo sapiens OX=9606 GN=KRT10 PE=1 SV=6 | 286.713 | cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes | plasma membrane;cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;other molecular function | 3858 | ENSG00000186395 | KRT10 | hsa:3858; P13645; Q14664; Q8N175 | Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.490821286240141 | 0.600890052902075 | 1.1091978559495355E8 | 9.409796786421584E7 | 1.13950700113199E8 | -0.23728126077989872 | 0.0388930557490876 | ||||||||
| Cont_P35908 | Keratin, type II cytoskeletal 2 epidermal OS=Homo sapiens OX=9606 GN=KRT2 PE=1 SV=2 | 284.975 | cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes | plasma membrane;cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;cytoskeletal activity | 3849 | ENSG00000172867 | KRT2 | hsa:3849; P35908; Q4VAQ2 | Formation of the cornified envelope | 0.411258958244596 | 0.499413631103761 | 4.776750778997586E7 | 2.9357809740500167E7 | 3.415287514761583E7 | -0.702285269017387 | -0.4840225715664078 | ||||||||
| Q62059 | Versican core protein [OS=Mus musculus] | 279.715 | cell adhesion;developmental processes | non-structural extracellular;extracellular matrix;other cell component | other molecular function | Vcan | Q62058; Q62059; Q9CUU0 | ECM proteoglycans; Glycosaminoglycan-protein linkage region biosynthesis; CS/DS degradation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; CS-GAG biosynthesis; DS-GAG biosynthesis | 1.8644578313253E-17 | 1.65082956259427E-17 | 104188.56292801573 | 9.037034497028168E7 | 9.467651077277745E7 | 9.760508702070462 | 9.827665809842685 | ||||||||||
| P10493 | Nidogen-1 [OS=Mus musculus] | 275.191 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | other molecular function | 18073 | ENSMUSG00000005397 | Nid1 | mmu:18073; P10493; Q3TKX9; Q8BQI3; Q8C3U8; Q8C9P6 | Laminin interactions; Degradation of the extracellular matrix | 1.8644578313253E-17 | 1.65082956259427E-17 | 322455.2944414853 | 1.2120394496125467E8 | 1.2671518083095133E8 | 8.554121783692475 | 8.618274500807305 | ||||||||
| O88207 | Collagen alpha-1(V) chain [OS=Mus musculus] | 275.025 | cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes | extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12831 | ENSMUSG00000026837 | Col5a1 | A3KGE3; mmu:12831; O88207; Q3UG94; Q6F6B0 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | ECM proteoglycans; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; MET activates PTK2 signaling | 1.8644578313253E-17 | 1.65082956259427E-17 | 80388.83753211687 | 3577832.3612721 | 8562033.320911517 | 5.475946792986802 | 6.734814451334498 | |||||||
| P37889 | Fibulin-2 [OS=Mus musculus] | 269.894 | other biological processes | non-structural extracellular | other molecular function | 14115 | ENSMUSG00000064080 | Fbln2 | G5E8B3; mmu:14115; P37889; Q9WUI2 | Molecules associated with elastic fibres | 0.0640195441309023 | 1.65082956259427E-17 | 362692.0010392267 | 6.556805587417743E7 | 8.021475911820169E7 | 7.498104380777058 | 7.78897897175684 | ||||||||
| Q8VHX6 | Filamin-C [OS=Mus musculus] | 249.498 | cell organization and biogenesis;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity | 68794 | ENSMUSG00000068699 | Flnc | B2RY80; B9EKT2; mmu:68794; Q6PAI6; Q8VHX6; Q9JJ38 | Cell-extracellular matrix interactions | 0.719627996749639 | 0.562594032195739 | 406087.97266412666 | 1016453.1391661359 | 2089599.8263247435 | 1.3236795012500113 | 2.3633624781914326 | ||||||||
| Q04857 | Collagen alpha-1(VI) chain [OS=Mus musculus] | 248.981 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component | other molecular function | 12833 | ENSMUSG00000001119 | Col6a1 | mmu:12833; Q04857 | ECM proteoglycans; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Signaling by PDGF; NCAM1 interactions | 0.392208211277376 | 0.2534363617947 | 76865.2077476112 | 5.0068940213435836E7 | 6.914260176814564E7 | 9.34736947879783 | 9.813028451743143 | ||||||||
| Cont_Q2UVX4 | Complement C3 OS=Bos taurus OX=9913 GN=C3 PE=1 SV=2 | 247.154 | cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular;other cell component | signal transduction activity or receptor binding;enzyme regulator activity | 280677 | ENSBTAG00000017280 | C3 | bta:280677; Q2KIZ4; Q2UVX4 | Complement and coagulation cascades; Complement activation, classical pathway | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Neutrophil degranulation; Peptide ligand-binding receptors; G alpha (i) signalling events; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade; Alternative complement activation; Activation of C3 and C5 | 0.798729234704005 | 0.615680953989958 | 1.4686759191254234E7 | 1.84550126489547E7 | 1.5291804049274266E7 | 0.329496643269344 | 0.058242535434261965 | |||||||
| Q62261 | Spectrin beta chain, non-erythrocytic 1 [OS=Mus musculus] | 244.684 | cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 20742 | ENSMUSG00000020315 | Sptbn1 | A2AFU1; mmu:20742; Q3TEM7; Q5SQL8; Q5SQL9; Q62261; Q9QWJ7 | COPI-mediated anterograde transport; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; RHOU GTPase cycle; Interaction between L1 and Ankyrins; RHOV GTPase cycle | 0.776437620310661 | 0.69394578118832 | 492454.03878621367 | 920886.7046363313 | 2921004.358024217 | 0.9030345918205293 | 2.568403522778103 | ||||||||
| Q640N1 | Adipocyte enhancer-binding protein 1 [OS=Mus musculus] | 239.707 | protein metabolism;other biological processes | nucleus;other cell component | nucleic acid binding activity;other molecular function | 11568 | ENSMUSG00000020473 | Aebp1 | mmu:11568; O88442; Q3TVV5; Q3TWA7; Q3TX56; Q3TXB2; Q5NCI9; Q61281; Q640N1 | 0.0457359864845759 | 0.269326617826563 | 4843934.666021533 | 3.9556778473622136E7 | 4.1143769603117764E7 | 3.029673625475387 | 3.0864226685149996 | |||||||||
| P57780 | Alpha-actinin-4 [OS=Mus musculus] | 239.42 | cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes | cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 60595 | ENSMUSG00000054808 | Actn4 | mmu:60595; P57780 | Primary focal segmental glomerulosclerosis (FSGS) | Platelet degranulation | 1.8644578313253E-17 | 1.65082956259427E-17 | 20900.169415734228 | 4580996.01302682 | 9830280.285985528 | 7.7760028602441835 | 8.877574105018988 | |||||||
| Q7TPR4 | Alpha-actinin-1 [OS=Mus musculus] | 235.529 | cell adhesion;cell organization and biogenesis;other biological processes | plasma membrane;other membranes;cytoskeleton;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function | 109711 | ENSMUSG00000015143 | Actn1 | mmu:109711; Q7TPR4 | Regulation of actin cytoskeleton; Integrin-mediated cell adhesion; Focal adhesion | Platelet degranulation ; RHOF GTPase cycle; RHOBTB2 GTPase cycle; RHOD GTPase cycle; Regulation of cytoskeletal remodeling and cell spreading by IPP complex components | 0.178726136005694 | 0.995554138371554 | 486802.1989182571 | 2525588.7379033365 | 6210475.170240924 | 2.3752121425876065 | 3.673296064913109 | |||||||
| P02468 | Laminin subunit gamma-1 [OS=Mus musculus] | 230.882 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | Lamc1 | P02468 | 0.116315527815218 | 0.118212047511996 | 18104.5719498812 | 7327169.184632126 | 1.61740059690847E7 | 8.660758050441677 | 9.803107266380897 | |||||||||||
| Q91ZX7 | Prolow-density lipoprotein receptor-related protein 1 [OS=Mus musculus] | 230.497 | other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;other molecular function | 16971 | Lrp1 | mmu:16971; Q61291; Q91ZX7; Q920Y4 | Statin pathway; Wnt signaling pathway | Scavenging of heme from plasma; Retinoid metabolism and transport | 0.0181625429641231 | 1.65082956259427E-17 | 30670.78727387535 | 3548407.5296101067 | 7355877.025944923 | 6.854162701489687 | 7.9058883521099 | ||||||||
| Cont_P60712 | Actin, cytoplasmic 1 OS=Bos taurus OX=9913 GN=ACTB PE=1 SV=1 | 225.45 | cell organization and biogenesis;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component | enzyme regulator activity;cytoskeletal activity;other molecular function | 100033878; 100135470; 100173832; 101844587; 102139853; 11461; 118833809; 280979; 396526; 403580; 414396; 443052; 450133; 60; 81822 | ENSBTAG00000026199; ENSCAFG00000016020; ENSCAFG00030015381; ENSCAFG00040015695; ENSCPOG00000013467; ENSG00000075624; ENSMAUG00000008763; ENSMUSG00000029580; ENSOARG00040012985; ENSOARG00180022443; ENSOARG00185023855; ENSOARG00215030140; ENSOARG00225009314; ENSPPYG00000017336; ENSPTRG00000018890; ENSRNOG00000034254; ENSSSCG00000007585; ENSSSCG00030003451; ENSSSCG00035038792; ENSSSCG00040049462; ENSSSCG00045027458; ENSSSCG00050065025; ENSSSCG00055012597; ENSSSCG00060019124; ENSSSCG00065037921; ENSSSCG00070011353; ENSSSCG00105030144; ENSSSCG00110026965; ENSSSCG00115013637; ENSSSCG00130033784 | Actb; ACTB | A5D961; A5PKA1; bta:280979; cfa:403580; cpoc:100135470; csab:103246953; ecb:100033878; gga:396526; hsa:60; maua:101844587; mmu:11461; O18840; oas:443052; P02570; P60706; P60707; P60708; P60709; P60710; P60711; P60712; P60713; P70514; P99021; pon:100173832; ptr:450133; Q11209; Q11211; Q3SZD2; Q3TI89; Q3TVP6; Q4L0Y2; Q4R561; Q5R1X3; Q5R582; Q5R6G0; Q64316; Q6QAQ1; Q6ZWM3; Q711N9; Q71FK5; Q75MN2; Q76N69; Q8MIJ0; Q8SPX4; Q95164; Q96B34; Q96HG5; rno:81822; ssc:414396 | FAS pathway and stress induction of HSP regulation; Actin cytoskeleton regulation; Myometrial relaxation and contraction pathways; Focal adhesion; Arrhythmogenic right ventricular cardiomyopathy; Pathogenic Escherichia coli infection; Common pathways underlying drug addiction; Myometrial relaxation and contraction pathways; Focal adhesion; Fas ligand pathway and stress induction of heat shock proteins; Pathogenic Escherichia coli infection; Arrhythmogenic right ventricular cardiomyopathy; Focal adhesion; Myometrial relaxation and contraction pathways; Regulation of actin cytoskeleton; Myometrial relaxation and contraction pathways; Ebola virus infection in host; Acute viral myocarditis; Thermogenesis; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Overlap between signal transduction pathways contributing to LMNA laminopathies; Pleural mesothelioma; Regulation of actin cytoskeleton; Network map of SARS-CoV-2 signaling; Regulation of actin cytoskeleton; Regulation of actin cytoskeleton; Focal adhesion | Formation of the canonical BAF (cBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); Regulation of actin dynamics for phagocytic cup formation; EPH-ephrin mediated repulsion of cells; Formation of annular gap junctions; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; RHO GTPases Activate Formins; RHOF GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; B-WICH complex positively regulates rRNA expression; Regulation of CDH1 Function; Formation of the dystrophin-glycoprotein complex (DGC); Formation of the canonical BAF (cBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); RHO GTPases Activate WASPs and WAVEs; UCH proteinases; DNA Damage Recognition in GG-NER; Formation of the non-canonical BAF (ncBAF) complex; RHO GTPases activate IQGAPs; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Cell-extracellular matrix interactions; MAP2K and MAPK activation; Interaction between L1 and Ankyrins; RHOF GTPase cycle; DNA Damage Recognition in GG-NER; MAP2K and MAPK activation; RHO GTPases Activate Formins; Clathrin-mediated endocytosis; UCH proteinases; RHOF GTPase cycle; DNA Damage Recognition in GG-NER; EPH-ephrin mediated repulsion of cells; VEGFA-VEGFR2 Pathway; Regulation of actin dynamics for phagocytic cup formation; Adherens junctions interactions; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); RHO GTPases Activate WASPs and WAVEs; B-WICH complex positively regulates rRNA expression; Regulation of CDH1 Function; EPHB-mediated forward signaling; Formation of the non-canonical BAF (ncBAF) complex; Formation of the canonical BAF (cBAF) complex; Formation of annular gap junctions; RHO GTPases activate IQGAPs; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; RHO GTPases Activate WASPs and WAVEs; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RHO GTPases activate IQGAPs; RHO GTPases Activate Formins; RHOF GTPase cycle; Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs); B-WICH complex positively regulates rRNA expression; Signaling by BRAF and RAF1 fusions; UCH proteinases; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; VEGFA-VEGFR2 Pathway; Formation of the dystrophin-glycoprotein complex (DGC); Factors involved in megakaryocyte development and platelet production; Regulation of MITF-M-dependent genes involved in pigmentation; Formation of the canonical BAF (cBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); EPH-ephrin mediated repulsion of cells; HATs acetylate histones; Interaction between L1 and Ankyrins; Prefoldin mediated transfer of substrate to CCT/TriC; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Adherens junctions interactions; Regulation of CDH1 Function; Formation of the non-canonical BAF (ncBAF) complex; DNA Damage Recognition in GG-NER; Formation of the polybromo-BAF (pBAF) complex; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Formation of annular gap junctions; Folding of actin by CCT/TriC; Cell-extracellular matrix interactions; MAP2K and MAPK activation; RHO GTPases Activate Formins; Recycling pathway of L1; RHO GTPases activate IQGAPs; Clathrin-mediated endocytosis; Formation of the dystrophin-glycoprotein complex (DGC); EPHB-mediated forward signaling; UCH proteinases; B-WICH complex positively regulates rRNA expression; Adherens junctions interactions; Formation of the non-canonical BAF (ncBAF) complex; Formation of annular gap junctions; Formation of the polybromo-BAF (pBAF) complex; VEGFA-VEGFR2 Pathway; Cell-extracellular matrix interactions; RHO GTPases Activate WASPs and WAVEs; Regulation of CDH1 Function; Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; UCH proteinases; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); Formation of the polybromo-BAF (pBAF) complex; B-WICH complex positively regulates rRNA expression; DNA Damage Recognition in GG-NER; Formation of the canonical BAF (cBAF) complex; RHO GTPases Activate Formins; Regulation of CDH1 Function; Interaction between L1 and Ankyrins; RHOF GTPase cycle; Formation of the non-canonical BAF (ncBAF) complex; Adherens junctions interactions; Formation of the dystrophin-glycoprotein complex (DGC); VEGFA-VEGFR2 Pathway; RHO GTPases Activate WASPs and WAVEs; Cell-extracellular matrix interactions; EPHB-mediated forward signaling; MAP2K and MAPK activation; Recycling pathway of L1; RHO GTPases activate IQGAPs; Formation of annular gap junctions; B-WICH complex positively regulates rRNA expression; UCH proteinases; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); MAP2K and MAPK activation; Formation of the polybromo-BAF (pBAF) complex; RHO GTPases Activate Formins; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases Activate WASPs and WAVEs; Formation of the dystrophin-glycoprotein complex (DGC); VEGFA-VEGFR2 Pathway; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; DNA Damage Recognition in GG-NER; RHOF GTPase cycle; Cell-extracellular matrix interactions; Adherens junctions interactions; Formation of the non-canonical BAF (ncBAF) complex; Formation of the canonical BAF (cBAF) complex; RHO GTPases activate IQGAPs; Regulation of CDH1 Function; Gap junction degradation; Formation of annular gap junctions; Regulation of actin dynamics for phagocytic cup formation; RHOF GTPase cycle; Clathrin-mediated endocytosis; RHO GTPases Activate Formins; Cell-extracellular matrix interactions; VEGFA-VEGFR2 Pathway; Adherens junctions interactions; RHO GTPases activate IQGAPs; UCH proteinases; EPHB-mediated forward signaling; MAP2K and MAPK activation; RHO GTPases Activate WASPs and WAVEs; Formation of the dystrophin-glycoprotein complex (DGC); Formation of annular gap junctions; Formation of the canonical BAF (cBAF) complex; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of the non-canonical BAF (ncBAF) complex; Regulation of CDH1 Function | 1.8644578313253E-17 | 1.65082956259427E-17 | 1996659.4544256767 | 4.828873920581084E7 | 6.5074451419171505E7 | 4.596026599796858 | 5.0264310485118315 | |||||||
| P63260 | Actin, cytoplasmic 2 [OS=Mus musculus] | 217.791 | cell organization and biogenesis;stress response;developmental processes;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 11465 | ENSMUSG00000062825 | Actg1 | mmu:11465; P02571; P14104; P63260; P99022 | Myometrial relaxation and contraction pathways; Regulation of actin cytoskeleton; Focal adhesion | Platelet degranulation ; RHO GTPases activate IQGAPs; Adherens junctions interactions; Regulation of CDH1 Function; RHO GTPases Activate Formins; Regulation of actin dynamics for phagocytic cup formation; Interaction between L1 and Ankyrins; MAP2K and MAPK activation; Recycling pathway of L1; Clathrin-mediated endocytosis; Formation of the dystrophin-glycoprotein complex (DGC); EPHB-mediated forward signaling; RHOF GTPase cycle; Formation of annular gap junctions; VEGFA-VEGFR2 Pathway; Cell-extracellular matrix interactions; RHO GTPases Activate WASPs and WAVEs; RHOBTB2 GTPase cycle | 1.8644578313253E-17 | 1.65082956259427E-17 | 145698.54484736864 | 254666.434448248 | ||||||||||
| P33434 | 72 kDa type IV collagenase [OS=Mus musculus] | 212.03 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes | extracellular matrix;plasma membrane;other membranes;cytoskeleton;mitochondrion;nucleus;other cell component | other molecular function | 17390 | ENSMUSG00000031740 | Mmp2 | mmu:17390; P33434 | Lung fibrosis; IL-3 signaling pathway; Matrix metalloproteinases | Collagen degradation; Extra-nuclear estrogen signaling; EPH-ephrin mediated repulsion of cells; Activation of Matrix Metalloproteinases | 0.964209443670126 | 0.372996577396536 | 2.5908623508144036E7 | 2.11513119484971E7 | 6.116415043649567E7 | -0.292685217123521 | 1.239253938445554 | |||||||
| P19096 | Fatty acid synthase [OS=Mus musculus] | 203.372 | other metabolic processes;stress response;other biological processes | plasma membrane;other membranes;cytosol;ER/Golgi;other cell component | other molecular function | 14104 | ENSMUSG00000025153 | Fasn | B1ATU8; mmu:14104; P19096; Q6PB72; Q8C4Z0; Q9EQR0 | Fatty acid biosynthesis; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-9 fatty acid synthesis; Elongation of (very) long chain fatty acids | Fatty acyl-CoA biosynthesis; Vitamin B5 (pantothenate) metabolism | 0.847457711018997 | 0.66189768147619 | 102793.32580216101 | 1389784.0897720233 | 2729524.669883373 | 3.757042269214309 | 4.730831235531711 | |||||||
| Cont_Q3SZ57 | Alpha-fetoprotein OS=Bos taurus OX=9913 GN=AFP PE=2 SV=1 | 202.89 | other metabolic processes;developmental processes;other biological processes | non-structural extracellular;other cell component | other molecular function | 506011 | ENSBTAG00000017131 | AFP | bta:506011; Q3SZ57 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 0.82964085881652 | 0.540832988168188 | 3.8603879197485335E7 | 4.5317948160280704E7 | 3.6151020512819335E7 | 0.23133671517440235 | -0.09470945341303746 | ||||||||
| P48678 | Prelamin-A/C [OS=Mus musculus] | 202.607 | cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes | other membranes;cytoskeleton;nucleus;other cell component | other molecular function | 16905 | ENSMUSG00000028063 | Lmna | B3RH23; B3RH24; mmu:16905; P11516; P48678; P97859; Q3TIH0; Q3TTS8; Q3U733; Q3U7I5; Q3UCA0; Q3UCJ8; Q3UCU3; Q91WF2; Q9DC21 | Adipogenesis genes; FAS pathway and stress induction of HSP regulation | 0.00670345592293191 | 1.65082956259427E-17 | 75722.11050192213 | 4134986.871037207 | 1.1058985470826533E7 | 5.771024316562613 | 7.190288704425306 | ||||||||
| Q02788 | Collagen alpha-2(VI) chain [OS=Mus musculus] | 202.37 | cell adhesion;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component | other molecular function | 12834 | ENSMUSG00000020241 | Col6a2 | mmu:12834; Q02788; Q05505; Q8C972; Q8K229 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | ECM proteoglycans; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation | 1.8644578313253E-17 | 0.175734701097799 | 121237.29953889274 | 4.136492509189963E7 | 5.21291258166705E7 | 8.414430536592976 | 8.748112233779976 | |||||||
| P97927 | Laminin subunit alpha-4 [OS=Mus musculus] | 199.33 | cell adhesion;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | signal transduction activity or receptor binding | 16775 | ENSMUSG00000019846 | Lama4 | mmu:16775; O88785; P70409; P97927; Q14BF2 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Formation of the dystrophin-glycoprotein complex (DGC); Laminin interactions; MET activates PTK2 signaling | 0.645007535999596 | 0.496649188935323 | 390078.69973194966 | 5125646.74812024 | 1.037511250312096E7 | 3.715896926492177 | 4.733217948190459 | |||||||
| P20152 | Vimentin [OS=Mus musculus] | 183.446 | cell organization and biogenesis;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component | cytoskeletal activity;nucleic acid binding activity;other molecular function | 22352 | ENSMUSG00000026728 | Vim | mmu:22352; O08704; P20152; Q8CCH1 | Spinal cord injury; Primary focal segmental glomerulosclerosis (FSGS); Alpha 6 beta 4 integrin signaling pathway | Aggrephagy; Striated Muscle Contraction; Caspase-mediated cleavage of cytoskeletal proteins; RHOBTB1 GTPase cycle | 0.0955146622024883 | 1.65082956259427E-17 | 1112472.104030337 | 7365249.698992513 | 3.3401280645601466E7 | 2.7269652767818724 | 4.908062353318758 | |||||||
| Q64727 | Vinculin [OS=Mus musculus] | 182.753 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | plasma membrane;other membranes;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 22330 | ENSMUSG00000021823 | Vcl | mmu:22330; Q64727; Q8BP32; Q8BS46; Q922C5; Q922D9 | Primary focal segmental glomerulosclerosis (FSGS); IL-3 signaling pathway; Regulation of actin cytoskeleton; Integrin-mediated cell adhesion; Focal adhesion | Neutrophil degranulation; High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells; Platelet degranulation ; MAP2K and MAPK activation; Smooth Muscle Contraction; Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells; Regulation of CDH1 Function | 0.190838415616571 | 0.208404050858596 | 126150.06188907423 | 1953982.7579073233 | 4840837.086136207 | 3.9532049177000044 | 5.262043723246207 | |||||||
| Q8K4G1 | Latent-transforming growth factor beta-binding protein 4 [OS=Mus musculus] | 180.216 | cell-cell signaling;cell organization and biogenesis;transport;signal transduction | non-structural extracellular;extracellular matrix | other molecular function | 108075 | ENSMUSG00000040488 | Ltbp4 | E9QPD9; mmu:108075; Q8K4G0; Q8K4G1 | TGF-beta receptor signaling activates SMADs; Molecules associated with elastic fibres | 0.362779483059131 | 0.308350896322176 | 50068.58855747415 | 1469976.6770863 | 2473680.681365607 | 4.875743668797631 | 5.626609683578324 | ||||||||
| Q68FD5 | Clathrin heavy chain 1 [OS=Mus musculus] | 180.117 | cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes | plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component | nucleic acid binding activity;other molecular function | 67300 | ENSMUSG00000047126 | Cltc | mmu:67300; Q68FD5 | IL-7 signaling pathway; Kit receptor signaling pathway | MHC class II antigen presentation; Recycling pathway of L1; Cargo recognition for clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis; LDL clearance; Retrograde neurotrophin signalling; Formation of annular gap junctions; Lysosome Vesicle Biogenesis; WNT5A-dependent internalization of FZD4; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation; RHOU GTPase cycle; RHOV GTPase cycle | 0.198232028950426 | 0.4248536990637 | 14581.209031729499 | 1426606.2225329466 | 2101059.0869428 | 6.612333012441563 | 7.170862575755155 | |||||||
| P02469 | Laminin subunit beta-1 [OS=Mus musculus] | 179.863 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;nucleus;other cell component | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 16777 | ENSMUSG00000002900 | Lamb1 | E9PXZ9; P02469 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Inflammatory response pathway; Alpha 6 beta 4 integrin signaling pathway; Focal adhesion | 0.341417478664423 | 0.205801242418232 | 1.0460538665187027E7 | 1.4326337702720901E7 | 1.8407714250900764E7 | 0.45371270995740953 | 0.8153533483670897 | ||||||||
| Q01853 | Transitional endoplasmic reticulum ATPase [OS=Mus musculus] | 179.055 | cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;other biological processes | other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;enzyme regulator activity;other molecular function | 269523 | ENSMUSG00000028452 | Vcp | mmu:269523; Q01853; Q3TFH9; Q3TIM2; Q3TXN9; Q6PI18; Q8BSR6; Q8CEG4 | IL-9 signaling pathway | RHOH GTPase cycle; Neutrophil degranulation; Protein methylation; Ovarian tumor domain proteases; Neddylation; ABC-family proteins mediated transport; Translesion Synthesis by POLH; Hedgehog ligand biogenesis; KEAP1-NFE2L2 pathway; HSF1 activation; N-glycan trimming in the ER and Calnexin/Calreticulin cycle; Josephin domain DUBs | 0.645007535999596 | 0.915230778358139 | 621808.5300221853 | 5338414.413398174 | 9329554.935730066 | 3.101868991218387 | 3.9072659463434927 | |||||||
| Q03350 | Thrombospondin-2 [OS=Mus musculus] | 178.303 | cell adhesion;other biological processes | non-structural extracellular;extracellular matrix;other cell component | other molecular function | 21826 | ENSMUSG00000023885 | Thbs2 | mmu:21826; Q03350; Q8CG21 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Signaling by PDGF; O-glycosylation of TSR domain-containing proteins | 0.861805134687803 | 0.425958502904743 | 1929828.2171104867 | 7439397.130180354 | 1.1102887711296873E7 | 1.9467132814492152 | 2.524390613497798 | |||||||
| Q80YX1 | Tenascin [OS=Mus musculus] | 175.9 | cell adhesion;cell-cell signaling;cell organization and biogenesis;stress response;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | signal transduction activity or receptor binding;other molecular function | 21923 | ENSMUSG00000028364 | Tnc | mmu:21923; Q64706; Q80YX1; Q80YX2 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Integrin cell surface interactions; ECM proteoglycans; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 0.827773046590747 | 0.117980756369098 | 20862.416559578665 | 1449614.4281484466 | 1.2106484504902953E7 | 6.118619130163546 | 9.18065799957951 | |||||||
| Q61147 | Ceruloplasmin [OS=Mus musculus] | 175.43 | cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular | other molecular function | 12870 | ENSMUSG00000003617 | Cp | mmu:12870; Q61147; Q6P5C8 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Iron uptake and transport; Metal ion SLC transporters | 0.0286042496128814 | 1.65082956259427E-17 | 116072.0240394514 | 4703216.257241024 | 9598922.193485493 | 5.340555472510453 | 6.369780225828648 | ||||||||
| Q3UQ28 | Peroxidasin homolog [OS=Mus musculus] | 173.636 | cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes | extracellular matrix;ER/Golgi;other cell component | extracellular structural activity;other molecular function | 69675 | ENSMUSG00000020674 | Pxdn | A4FU83; E9QNQ9; mmu:69675; Q3UQ28 | Crosslinking of collagen fibrils | 0.199060935853007 | 0.121749369203589 | 52188.79804577449 | 3468268.863888983 | 1.0141728842991263E7 | 6.054331756125822 | 7.602347715901429 | ||||||||
| Q61316 | Heat shock 70 kDa protein 4 [OS=Mus musculus] | 169.044 | protein metabolism;other metabolic processes | other cell component | other molecular function | Hspa4 | Q61316 | Regulation of HSF1-mediated heat shock response | 0.947627746595709 | 0.675982462193546 | 51496.56273693644 | 1715523.4149199834 | 3885769.0116153997 | 5.058028867603881 | 6.2375801933412385 | ||||||||||
| Cont_P02533 | Keratin, type I cytoskeletal 14 OS=Homo sapiens OX=9606 GN=KRT14 PE=1 SV=4 | 164.831 | cell organization and biogenesis;other biological processes | plasma membrane;cytosol;cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 3861 | ENSG00000186847 | KRT14 | hsa:3861; P02533; Q14715; Q53XY3; Q9BUE3; Q9UBN2; Q9UBN3; Q9UCY4 | Corticotropin-releasing hormone signaling | Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin; Developmental Lineage of Mammary Gland Myoepithelial Cells; Type I hemidesmosome assembly | 0.880930298968675 | 0.821333803243143 | 6829492.454091667 | 1.0299655985485494E7 | 9892865.41378706 | 0.5927458802001806 | 0.5346100841122959 | |||||||
| P11499 | Heat shock protein HSP 90-beta [OS=Mus musculus] | 164.719 | cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component | enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function | 15516 | ENSMUSG00000023944 | Hsp90ab1 | mmu:15516; O89078; P11499; Q3UIQ7 | Focal adhesion: PI3K-Akt-mTOR signaling pathway | Neutrophil degranulation; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of actin dynamics for phagocytic cup formation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Attenuation phase; Estrogen-dependent gene expression; Sema3A PAK dependent Axon repulsion; Aryl hydrocarbon receptor signalling; DDX58/IFIH1-mediated induction of interferon-alpha/beta; HSF1 activation; RHOBTB2 GTPase cycle; The NLRP3 inflammasome | 1.8644578313253E-17 | 1.65082956259427E-17 | 166033.98771248801 | 1.0807613687705928E7 | 3.193268303009924E7 | 6.024425605817814 | 7.587411368791836 | |||||||
| Q9JKF1 | Ras GTPase-activating-like protein IQGAP1 [OS=Mus musculus] | 163.926 | cell organization and biogenesis;developmental processes;signal transduction;other biological processes | plasma membrane;other membranes;cytoskeleton;nucleus;other cell component | enzyme regulator activity;other molecular function | 29875 | ENSMUSG00000030536 | Iqgap1 | G3UW45; mmu:29875; Q9JKF1 | G13 signaling pathway; Regulation of actin cytoskeleton | RHO GTPases activate IQGAPs; Neutrophil degranulation; RAC1 GTPase cycle; RAC2 GTPase cycle; RHOA GTPase cycle; MAP2K and MAPK activation; RHOQ GTPase cycle; RHOC GTPase cycle; RHOU GTPase cycle; RHOV GTPase cycle; Nephrin family interactions | 0.794460986683881 | 0.930229675308081 | 58984.367745696 | 331165.4406654323 | 1068898.0084058929 | 2.489147563897488 | 4.1796477342414615 | |||||||
| P52480 | Pyruvate kinase PKM [OS=Mus musculus] | 163.393 | cell organization and biogenesis;other metabolic processes;other biological processes | cytosol;ER/Golgi;nucleus;other cell component | nucleic acid binding activity;kinase activity;other molecular function | 18746 | ENSMUSG00000032294 | Pkm | mmu:18746; P52480; Q3TBV8; Q3TBW5; Q3TC59; Q3U1X3; Q3U5P6; Q4VC20; Q64484; Q91YI8; Q9CWB1 | Glycolysis and gluconeogenesis; Purine metabolism | Neutrophil degranulation; Pyruvate metabolism; Glycolysis; Regulation of pyruvate metabolism | 1.8644578313253E-17 | 1.65082956259427E-17 | 224031.9482756436 | 1.1706302394897154E7 | 1.6687028973496003E7 | 5.707437157684907 | 6.218878820280579 | |||||||
| P63017 | Heat shock cognate 71 kDa protein [OS=Mus musculus] | 161.557 | cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component | signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function | 15481 | ENSMUSG00000015656 | Hspa8 | mmu:15481; P08109; P12225; P63017; Q3U6R0; Q3U764; Q3U7D7; Q3U7E2; Q3U9B4; Q3U9G0; Q3UGM0; Q5FWJ6; Q62373; Q62374; Q62375; Q6NZD0 | Mapk signaling pathway; Exercise-induced circadian regulation | Neutrophil degranulation; mRNA Splicing - Major Pathway; Regulation of HSF1-mediated heat shock response; PKR-mediated signaling; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis; Attenuation phase; Lysosome Vesicle Biogenesis; GABA synthesis, release, reuptake and degradation; AUF1 (hnRNP D0) binds and destabilizes mRNA; Protein methylation | 1.8644578313253E-17 | 1.65082956259427E-17 | 232221.67704249235 | 1.5723480869725833E7 | 2.2348098618015703E7 | 6.081274178280651 | 6.588505632754927 | |||||||
| Q9JHU4 | Cytoplasmic dynein 1 heavy chain 1 [OS=Mus musculus] | 161.009 | cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes | cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 13424 | ENSMUSG00000018707 | Dync1h1 | E9QM71; mmu:13424; Q9JHU4 | MHC class II antigen presentation; Neutrophil degranulation; Separation of Sister Chromatids; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; COPI-mediated anterograde transport; Recruitment of NuMA to mitotic centrosomes; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-independent Golgi-to-ER retrograde traffic; Aggrephagy; Anchoring of the basal body to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; AURKA Activation by TPX2 | 0.826895204418257 | 0.591873375996003 | 294620.0253220563 | 451351.8596347517 | 1275535.4534856554 | 0.6153970578330761 | 2.1141756003853147 | ||||||||
| Q99K41 | EMILIN-1 [OS=Mus musculus] | 157.011 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 100952 | ENSMUSG00000029163 | Emilin1 | mmu:100952; Q99K41 | Molecules associated with elastic fibres | 1.8644578313253E-17 | 1.65082956259427E-17 | 1671715.86234765 | 5498413.09956387 | |||||||||||
| Q61879 | Myosin-10 [OS=Mus musculus] | 146 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;nucleic acid binding activity;other molecular function | 77579 | ENSMUSG00000020900 | Myh10 | mmu:77579; Q5SV63; Q61879 | Regulation of actin cytoskeleton | RHO GTPases activate PAKs | 0.506231596289679 | 0.705689538076567 | 123378.89612673952 | 266023.60455562966 | 458865.269073755 | 1.108458619642415 | 1.8949749715174342 | |||||||
| Cont_P00761 | Trypsin OS=Sus scrofa OX=9823 PE=1 SV=1 | 143.502 | protein metabolism;other biological processes | non-structural extracellular | other molecular function | 0.172153475402034 | 0.254996071775817 | 5.863252009900073E9 | 3.334729419178533E9 | 2.1792138371661735E9 | -0.8141313613991668 | -1.4278932978551737 | |||||||||||||
| P20029 | Endoplasmic reticulum chaperone BiP [OS=Mus musculus] | 142.966 | protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component | enzyme regulator activity;translation activity;other molecular function | 14828 | ENSMUSG00000026864 | Hspa5 | mmu:14828; O35642; P20029; Q3UFF2; Q61630 | Mapk signaling pathway | Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Regulation of HSF1-mediated heat shock response | 1.8644578313253E-17 | 1.65082956259427E-17 | 7392689.481756757 | 8222965.927916382 | ||||||||||
| Cont_P13647 | Keratin, type II cytoskeletal 5 OS=Homo sapiens OX=9606 GN=KRT5 PE=1 SV=3 | 142.395 | cell organization and biogenesis;other biological processes | cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;cytoskeletal activity;other molecular function | 3852 | ENSG00000186081 | KRT5 | hsa:3852; P13647; Q6PI71; Q6UBJ0; Q8TA91 | Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin; Developmental Lineage of Mammary Stem Cells; Developmental Lineage of Mammary Gland Myoepithelial Cells; Type I hemidesmosome assembly | 0.847457711018997 | 0.786915923361782 | 5615099.536380176 | 7868513.182470503 | 9974982.226041706 | 0.4867794560282899 | 0.8290026737979193 | ||||||||
| Cont_P08779 | Keratin, type I cytoskeletal 16 OS=Homo sapiens OX=9606 GN=KRT16 PE=1 SV=4 | 140.751 | cell organization and biogenesis;stress response;other biological processes | plasma membrane;cytosol;cytoskeleton | cytoskeletal activity | 3868 | ENSG00000186832 | KRT16 | A8K488; hsa:3868; P08779; P30654; Q16402; Q9UBG8 | Vitamin D receptor pathway | Formation of the cornified envelope | 0.961351301268194 | 0.941324060398065 | 1275668.1444026066 | 3908256.3409277797 | 2249474.51763106 | 1.615272024678325 | 0.8183349524474691 | |||||||
| Cont_P02465 | Collagen alpha-2(I) chain OS=Bos taurus OX=9913 GN=COL1A2 PE=1 SV=2 | 139.99 | non-structural extracellular;extracellular matrix | extracellular structural activity;other molecular function | 282188 | ENSBTAG00000013472 | COL1A2 | A6QP13; bta:282188; O62649; P02465 | Inflammatory response pathway; Focal adhesion | Fibronectin matrix formation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Collagen degradation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; Collagen chain trimerization; GPVI-mediated activation cascade; Platelet Aggregation (Plug Formation); Platelet Adhesion to exposed collagen; GP1b-IX-V activation signalling | 0.876027096029978 | 0.483779141493222 | 70110.45197339094 | 85775.39066064726 | 163731.944383145 | 0.29093425615940965 | 1.223634381101149 | ||||||||
| Cont_P12763 | Alpha-2-HS-glycoprotein OS=Bos taurus OX=9913 GN=AHSG PE=1 SV=2 | 132.772 | stress response;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component | enzyme regulator activity | 280988 | AHSG | A6QLF7; bta:280988; P12763 | Neutrophil degranulation; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 0.793013134473823 | 0.573667790345329 | 6.882384659684638E8 | 8.712402787486216E8 | 6.41500953397899E8 | 0.3401621263323422 | -0.10145711777808486 | |||||||||
| P07901 | Heat shock protein HSP 90-alpha [OS=Mus musculus] | 132.382 | cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component | signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function | 15519 | ENSMUSG00000021270 | Hsp90aa1 | mmu:15519; P07901 | EBV LMP1 signaling; Focal adhesion: PI3K-Akt-mTOR signaling pathway; IL-6 signaling pathway; IL-2 signaling pathway | Regulation of necroptotic cell death; Recruitment of NuMA to mitotic centrosomes; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of actin dynamics for phagocytic cup formation; Neutrophil degranulation; Downregulation of ERBB2 signaling; Anchoring of the basal body to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; AURKA Activation by TPX2; Extra-nuclear estrogen signaling; Attenuation phase; Estrogen-dependent gene expression; Sema3A PAK dependent Axon repulsion; VEGFR2 mediated vascular permeability; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation; DDX58/IFIH1-mediated induction of interferon-alpha/beta; eNOS activation; HSF1 activation; RHOBTB2 GTPase cycle; Drug-mediated inhibition of ERBB2 signaling | 0.508730894200713 | 1.65082956259427E-17 | 138049.65358917884 | 1667357.9717776468 | 3968795.71909318 | 3.594304702710527 | 4.845442133334701 | |||||||
| Q02819 | Nucleobindin-1 [OS=Mus musculus] | 131.152 | signal transduction | non-structural extracellular;other membranes;ER/Golgi | enzyme regulator activity;nucleic acid binding activity;other molecular function | 18220 | ENSMUSG00000030824 | Nucb1 | mmu:18220; Q02819; Q3TU42; Q9CWA1; Q9D8J4; Q9DBL3 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 1.8644578313253E-17 | 1.65082956259427E-17 | 30635.69892492515 | 5493436.34719679 | 1.9240052036173E7 | 7.4863513149475525 | 9.294683220219179 | ||||||||
| Q91V92 | ATP-citrate synthase [OS=Mus musculus] | 129.973 | other metabolic processes | cytosol | other molecular function | 104112 | ENSMUSG00000020917 | Acly | mmu:104112; Q91V92 | Fatty acid biosynthesis | Neutrophil degranulation; Fatty acyl-CoA biosynthesis | 0.371468864113786 | 0.230775890814232 | 27537.414327710998 | 1276919.6113413726 | 2339759.4103227933 | 5.535130791068342 | 6.408823278146731 | |||||||
| A2ASQ1 | Agrin [OS=Mus musculus] | 128.989 | cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cell component | signal transduction activity or receptor binding;other molecular function | 11603 | ENSMUSG00000041936 | Agrn | A2ASP9; A2ASQ0; A2ASQ1; B2RWU1 | Primary focal segmental glomerulosclerosis (FSGS) | ECM proteoglycans; Retinoid metabolism and transport; Glycosaminoglycan-protein linkage region biosynthesis; HS-GAG biosynthesis; HS-GAG degradation; Formation of the dystrophin-glycoprotein complex (DGC) | 1.8644578313253E-17 | 1.65082956259427E-17 | 1695001.2322350666 | 3018900.06344302 | ||||||||||
| Q61508 | Extracellular matrix protein 1 [OS=Mus musculus] | 127.379 | stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular | signal transduction activity or receptor binding;other molecular function | 13601 | ENSMUSG00000028108 | Ecm1 | mmu:13601; Q3U5Q5; Q61508 | Platelet degranulation | 1.8644578313253E-17 | 1.65082956259427E-17 | 74811.39241511819 | 5.132626536679041E7 | 6.196550035866306E7 | 9.422223591696405 | 9.69399151201845 | ||||||||
| Cont_P04259 | Keratin, type II cytoskeletal 6B OS=Homo sapiens OX=9606 GN=KRT6B PE=1 SV=5 | 126.901 | cell organization and biogenesis;other biological processes | cytosol;cytoskeleton | bone, tooth or skin structural activity;cytoskeletal activity | 3854 | ENSG00000185479 | KRT6B | hsa:3854; P04259; P48669 | Formation of the cornified envelope | 0.868132360832926 | 0.857251372850113 | 298970.1410949 | 1156058.5455969477 | 510017.07482617133 | 1.9511411501265994 | 0.7705441417687864 | ||||||||
| P17182 | Alpha-enolase [OS=Mus musculus] | 126.804 | other metabolic processes;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;other cell component | nucleic acid binding activity;other molecular function | 13806; 433182 | ENSMUSG00000059040; ENSMUSG00000063524 | Eno1 | mmu:13806; mmu:433182; P17182; Q99KT7; Q9DCY7 | Glycolysis and gluconeogenesis | 1.8644578313253E-17 | 1.65082956259427E-17 | 47358.53377381337 | 9473047.660860082 | 1.1146559483992001E7 | 7.644060417133689 | 7.878758343175162 | ||||||||
| P08113 | Endoplasmin [OS=Mus musculus] | 126.346 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cell component | signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function | 22027 | ENSMUSG00000020048 | Hsp90b1 | mmu:22027; P08113; P11427 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Hypoxia-dependent self-renewal of myoblasts | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Scavenging by Class A Receptors; Trafficking and processing of endosomal TLR; Interleukin-4 and Interleukin-13 signaling | 0.0104456807471941 | 0.107476768049312 | 52582.03853978356 | 4030450.84914005 | 5006439.15200075 | 6.2602273439427725 | 6.573070961339852 | |||||||
| P58252 | Elongation factor 2 [OS=Mus musculus] | 126.048 | cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;translational apparatus;other cell component | cytoskeletal activity;translation activity;nucleic acid binding activity;other molecular function | 13629 | ENSMUSG00000034994 | Eef2 | mmu:13629; P58252; Q544E4 | Translation factors | Neutrophil degranulation; Protein methylation; Peptide chain elongation; Synthesis of diphthamide-EEF2 | 0.188334321166369 | 0.299809054080284 | 229633.38558146535 | 6414138.274151959 | 1.0566307796994643E7 | 4.8038511446429455 | 5.523995125592705 | |||||||
| Cont_P02538 | Keratin, type II cytoskeletal 6A OS=Homo sapiens OX=9606 GN=KRT6A PE=1 SV=3 | 123.757 | cell organization and biogenesis;stress response;other biological processes | cytosol;cytoskeleton | bone, tooth or skin structural activity;cytoskeletal activity | 3853 | ENSG00000205420 | KRT6A | A4QPC1; hsa:3853; P02538; P48667; Q08AR4; Q6NT67; Q96CL4 | Ectoderm differentiation; Ectoderm differentiation; Pancreatic cancer subtypes | Formation of the cornified envelope | 0.964633336683333 | 0.892533464536408 | 2182876.549653717 | 4785085.111074816 | 3779160.7730984767 | 1.1323140432879846 | 0.7918353525552961 | |||||||
| P97298 | Pigment epithelium-derived factor [OS=Mus musculus] | 123.502 | cell cycle OR cell proliferation;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | enzyme regulator activity | 20317 | ENSMUSG00000000753 | Serpinf1 | mmu:20317; O70629; O88691; P97298 | 0.227296093012204 | 1.65082956259427E-17 | 462579.17347644636 | 1.46490289953418E7 | 7.121805491857927E7 | 4.984960915629733 | 7.266398910121059 | |||||||||
| Q70E20 | Sushi, nidogen and EGF-like domain-containing protein 1 [OS=Mus musculus] | 122.942 | cell adhesion | non-structural extracellular;extracellular matrix | other molecular function | 208777 | Sned1 | A6H6I3; mmu:208777; Q70E20; Q810H2; Q8BMD9 | 1.8644578313253E-17 | 1.65082956259427E-17 | 37861.533059704365 | 3293936.3484006864 | 6267209.5561869135 | 6.442936037948125 | 7.370946594278482 | ||||||||||
| P13020 | Gelsolin [OS=Mus musculus] | 122.934 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 227753 | ENSMUSG00000026879 | Gsn | mmu:227753; P13020; Q3UPB1; Q8R590 | Regulation of actin cytoskeleton | Neutrophil degranulation; Caspase-mediated cleavage of cytoskeletal proteins | 0.396306424610341 | 0.440427841758307 | 1139775.9088509877 | 6438031.44422588 | 9825643.045518672 | 2.497869418910709 | 3.1078016243224496 | |||||||
| Q61398 | Procollagen C-endopeptidase enhancer 1 [OS=Mus musculus] | 120.4 | protein metabolism;other biological processes | enzyme regulator activity;other molecular function | 18542 | ENSMUSG00000029718 | Pcolce | mmu:18542; O35113; Q61398 | mRNA processing | Collagen biosynthesis and modifying enzymes; Crosslinking of collagen fibrils | 1.8644578313253E-17 | 1.65082956259427E-17 | 84503.2651712337 | 2.52047208020085E7 | 2.958750643636163E7 | 8.220471170449764 | 8.451765311848972 | ||||||||
| P26039 | Talin-1 [OS=Mus musculus] | 118.226 | cell adhesion;cell organization and biogenesis;signal transduction | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;other molecular function | 21894 | ENSMUSG00000028465 | Tln1 | A2AIM8; mmu:21894; P26039; Q8VEF0 | Primary focal segmental glomerulosclerosis (FSGS); Integrin-mediated cell adhesion; Focal adhesion | Platelet degranulation ; MAP2K and MAPK activation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; Smooth Muscle Contraction; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 0.994542145304377 | 0.958262397335385 | 147890.2697082064 | 165904.24421521465 | 567933.664164035 | 0.1658236593620016 | 1.9411952948940325 | |||||||
| Q8BPB5 | EGF-containing fibulin-like extracellular matrix protein 1 [OS=Mus musculus] | 117.738 | protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes | extracellular matrix | signal transduction activity or receptor binding;kinase activity;other molecular function | 216616 | ENSMUSG00000020467 | Efemp1 | mmu:216616; Q6Y3N6; Q8BPB5 | 1.8644578313253E-17 | 1.65082956259427E-17 | 29995.485006469138 | 4441372.613318663 | 7007290.288389671 | 7.210116443386737 | 7.867967494142903 | |||||||||
| P09411 | Phosphoglycerate kinase 1 [OS=Mus musculus] | 116.462 | protein metabolism;other metabolic processes;stress response;other biological processes | non-structural extracellular;other membranes;cytosol;mitochondrion;other cell component | kinase activity;other molecular function | 18655 | ENSMUSG00000062070 | Pgk1 | mmu:18655; P09411; Q3TPE6; Q3UKV8; Q5XJE7 | Glycolysis and gluconeogenesis | Gluconeogenesis; Glycolysis | 1.8644578313253E-17 | 1.65082956259427E-17 | 46750.53578358531 | 3210948.6178334034 | 3594147.655304653 | 6.10187286968957 | 6.264522969777913 | |||||||
| P27773 | Protein disulfide-isomerase A3 [OS=Mus musculus] | 115.891 | cell adhesion;cell organization and biogenesis;stress response;signal transduction;other biological processes | non-structural extracellular;other membranes;ER/Golgi;other cell component | nucleic acid binding activity;other molecular function | 14827 | ENSMUSG00000027248 | Pdia3 | mmu:14827; P27773; Q3TEI9; Q3TIL2; Q3UZK8; Q8C2F4; Q99LF6 | ER-Phagosome pathway; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Calnexin/calreticulin cycle | 0.736536116100563 | 0.9135584231482 | 196243.61956605766 | 5161827.016313557 | 6480316.532156386 | 4.717164140703168 | 5.045346629722291 | ||||||||
| P10107 | Annexin A1 [OS=Mus musculus] | 115.566 | cell organization and biogenesis;stress response;transport;signal transduction;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component | enzyme regulator activity;other molecular function | 16952 | ENSMUSG00000024659 | Anxa1 | mmu:16952; P10107 | Spinal cord injury; Prostaglandin synthesis and regulation | G alpha (q) signalling events; G alpha (i) signalling events; Formyl peptide receptors bind formyl peptides and many other ligands | 0.105053536950499 | 1.65082956259427E-17 | 8983.410658903753 | 1675870.316312303 | 6017153.19339518 | 7.543431512773922 | 9.387602086782305 | |||||||
| Cont_Q2KJF1 | Alpha-1B-glycoprotein OS=Bos taurus OX=9913 GN=A1BG PE=1 SV=1 | 115.502 | signal transduction | non-structural extracellular;plasma membrane;other membranes | 518955 | A1BG | bta:518955; Q2KJF1 | Platelet degranulation ; Neutrophil degranulation | 0.655487072215252 | 0.635218461842139 | 9385194.584847162 | 9820849.23751892 | 8859077.038578315 | 0.0654611269786279 | -0.08323025407879855 | ||||||||||
| Cont_Q3MHN5 | Vitamin D-binding protein OS=Bos taurus OX=9913 GN=GC PE=2 SV=1 | 113.599 | other metabolic processes;transport | non-structural extracellular;other cell component | transporter activity;cytoskeletal activity;other molecular function | 530076 | GC | bta:530076; Q3MHN5 | 0.804331105646976 | 0.549057967251154 | 1.2784681703575822E7 | 1.5974245944817802E7 | 1.026921939097026E7 | 0.3213315885051744 | -0.3160897225178924 | ||||||||||
| P17742 | Peptidyl-prolyl cis-trans isomerase A [OS=Mus musculus] | 113.527 | cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes | non-structural extracellular;cytosol;nucleus;other cell component | signal transduction activity or receptor binding;other molecular function | 268373 | ENSMUSG00000071866 | Ppia | mmu:268373; P17742; Q9CWJ5; Q9R137 | Neutrophil degranulation; Basigin interactions | 0.099382125133403 | 0.100219677394751 | 5533917.143041036 | 1.0145464905716315E7 | 3.610988970082183E7 | 0.8744620282868188 | 2.706021065150085 | ||||||||
| Q69ZN7 | Myoferlin [OS=Mus musculus] | 112.647 | cell organization and biogenesis;other metabolic processes;stress response;other biological processes | plasma membrane;other membranes;nucleus | other molecular function | 226101 | ENSMUSG00000048612 | Myof | mmu:226101; Q69ZN7; Q7TMG0; Q80V33; Q8BU64; Q8BU70; Q8BUC1; Q8BVY6; Q8C0D1; Q8R3B4 | 0.964709887217926 | 0.73657372909066 | 74563.786625436 | 322363.41862436634 | 911704.7850761963 | 2.1121410056571723 | 3.6120197152096933 | |||||||||
| P26041 | Moesin [OS=Mus musculus] | 112.068 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function | 17698 | ENSMUSG00000031207 | Msn | B1AX70; mmu:17698; P26041; Q3UL28; Q8BSN4 | Regulation of actin cytoskeleton | Recycling pathway of L1 | 0.0604972675946614 | 1.65082956259427E-17 | 3564499.916018247 | 9136364.2843242 | 1.7052591672350097E7 | 1.3579204878919158 | 2.258219426272545 | |||||||
| P05064 | Fructose-bisphosphate aldolase A [OS=Mus musculus] | 112.015 | cell organization and biogenesis;other metabolic processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | other molecular function | 11674 | ENSMUSG00000030695 | Aldoa | mmu:11674; P05064 | Glycolysis and gluconeogenesis | Platelet degranulation ; Neutrophil degranulation; Gluconeogenesis; Glycolysis | 0.00616383846364181 | 0.101571037453114 | 21908.055682018665 | 4319055.57861477 | 4893427.94836492 | 7.623110619104784 | 7.803240194807217 | |||||||
| B2RQC6 | Multifunctional protein CAD [OS=Mus musculus] | 111.853 | other metabolic processes;stress response;transport;developmental processes;other biological processes | cytosol;nucleus;other cell component | kinase activity;other molecular function | 69719 | ENSMUSG00000013629 | Cad | B2RQC6; B7ZN27; mmu:69719 | Mechanisms associated with pluripotency | Pyrimidine biosynthesis | 0.6681512188534 | 0.69394578118832 | 34439.61575478624 | 448793.6641228067 | 957747.5456383955 | 3.7039113570511004 | 4.797504471859518 | |||||||
| Q8BND5 | Sulfhydryl oxidase 1 [OS=Mus musculus] | 111.186 | cell organization and biogenesis;other biological processes | non-structural extracellular;other membranes;ER/Golgi | other molecular function | 104009 | ENSMUSG00000033684 | Qsox1 | mmu:104009; Q3TDY9; Q3TE19; Q3TR29; Q3UEL4; Q8BND5; Q8K041; Q9DBL6 | Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Neutrophil degranulation | 1.8644578313253E-17 | 1.65082956259427E-17 | 25068.200750320597 | 3849451.1157268733 | 1.052758137572049E7 | 7.262650488092563 | 8.714099860277624 |
A
B
C
D
E
F
G
H
I
J
K
L
M
N
O
P
Q
R
S
601
602
603
604
605
606
607
608
609
610
611
612
613
614
615
616
617
618
619
620
621
622
623
624
625
626
627
628
629
630
631
632
633
634
635
636
637
638
639
640
641
642
643
644
645
646
647
648
649
650
651
652
653
654
655
656
657
658
659
660
661
662
663
664
665
666
667
668
669
670
671
672
673
674
675
676
677
678
679
680
681
682
683
684
685
686
687
688
689
690
691
692
693
694
695
696
697
698
699
700
| Q01721 | Growth arrest-specific protein 1 [OS=Mus musculus] | 24.776 | cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes | plasma membrane;other membranes | other molecular function | 14451 | ENSMUSG00000052957 | Gas1 | mmu:14451; Q01721 | Hedgehog signaling pathway | Activation of SMO; Ligand-receptor interactions | 0.837929303393801 | 0.776025835706249 | 89200.6335776345 | 217136.9235356087 | 749340.015957789 | 1.2834792106073365 | 1.7870154226255572 |
| P47754 | F-actin-capping protein subunit alpha-2 [OS=Mus musculus] | 24.685 | cell organization and biogenesis | other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity | 12343 | ENSMUSG00000015733 | Capza2 | mmu:12343; P47754 | COPI-mediated anterograde transport; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-independent Golgi-to-ER retrograde traffic; Factors involved in megakaryocyte development and platelet production; Advanced glycosylation endproduct receptor signaling | 1.70336894001643E-17 | 1.50457038391225E-17 | 167423.047285137 | 615020.2929395547 | 1.8771358722892757 | |||
| Q9WUU7 | Cathepsin Z [OS=Mus musculus] | 24.675 | protein metabolism;developmental processes;other biological processes | non-structural extracellular;ER/Golgi;other cytoplasmic organelle;other cell component | other molecular function | 64138 | ENSMUSG00000016256 | Ctsz | mmu:64138; Q9WUU7 | Neutrophil degranulation; Metabolism of Angiotensinogen to Angiotensins; COPII-mediated vesicle transport; Cargo concentration in the ER; Lysosome Vesicle Biogenesis | 0.963689578772028 | 0.809948223138506 | 8920.36670696029 | 496709.1806638623 | 1010140.5119157064 | 5.799154583042855 | 1.0240826703413772 | |
| Q60716 | Prolyl 4-hydroxylase subunit alpha-2 [OS=Mus musculus] | 24.612 | ER/Golgi | other molecular function | 18452 | ENSMUSG00000018906 | P4ha2 | mmu:18452; Q60716; Q8VBU4 | Collagen biosynthesis and modifying enzymes | 0.715842182051761 | 0.993241201071406 | 23419.4800895879 | 417266.3707417383 | 700299.2058230367 | 4.1551876987996055 | 0.7470027989818758 | ||
| P49722 | Proteasome subunit alpha type-2 [OS=Mus musculus] | 24.608 | protein metabolism;other metabolic processes;other biological processes | cytosol;nucleus;other cell component | 19166 | ENSMUSG00000015671 | Psma2 | E9Q3A4; mmu:19166; P49722; Q6ZWV8 | Proteasome degradation | Neutrophil degranulation; ER-Phagosome pathway; Hedgehog ligand biogenesis; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Neddylation; Asymmetric localization of PCP proteins; Degradation of AXIN; Hedgehog 'on' state; Ub-specific processing proteases; Regulation of RUNX3 expression and activity; Antigen processing: Ubiquitination & Proteasome degradation; Autodegradation of Cdh1 by Cdh1:APC/C; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; Assembly of the pre-replicative complex; CDK-mediated phosphorylation and removal of Cdc6; The role of GTSE1 in G2/M progression after G2 checkpoint; MAPK6/MAPK4 signaling; UCH proteinases; Regulation of PTEN stability and activity; ABC-family proteins mediated transport; Regulation of RAS by GAPs; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Degradation of CDH1; Regulation of ornithine decarboxylase (ODC); Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF(Skp2)-mediated degradation of p27/p21; Degradation of beta-catenin by the destruction complex; Autodegradation of the E3 ubiquitin ligase COP1; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of DVL; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; GLI3 is processed to GLI3R by the proteasome; NIK-->noncanonical NF-kB signaling; Orc1 removal from chromatin; G2/M Checkpoints; Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Proteasome assembly; Antigen processing: Ub, ATP-independent proteasomal degradation; Degradation of CRY and PER proteins | 1.70336894001643E-17 | 1.50457038391225E-17 | 171155.71066809833 | 282072.62227248866 | 0.7207572168133448 | |||
| P10711 | Transcription elongation factor A protein 1 [OS=Mus musculus] | 24.564 | RNA metabolism OR transcription;other metabolic processes;other biological processes | nucleus | nucleic acid binding activity;other molecular function | 21399 | ENSMUSG00000033813 | Tcea1 | mmu:21399; P10711; P10712; P23713 | Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes | 0.963689578772028 | 0.356778307004056 | 3444.086607919765 | 66834.7184123591 | 519418.97025169805 | 4.278404401953488 | 2.9582290705743994 | |
| P62196 | 26S proteasome regulatory subunit 8 [OS=Mus musculus] | 24.542 | protein metabolism;other metabolic processes;other biological processes | cytosol;nucleus;other cell component | signal transduction activity or receptor binding;other molecular function | 19184 | ENSMUSG00000020708 | Psmc5 | mmu:19184; O35051; P47210; P52915; P52916; P62196; Q3UL51; Q9CWN5 | Proteasome degradation | Degradation of CDH1; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Interleukin-1 signaling; Activation of NF-kappaB in B cells; Neddylation; Asymmetric localization of PCP proteins; Degradation of AXIN; Hedgehog 'on' state; Ub-specific processing proteases; Regulation of RUNX3 expression and activity; Autodegradation of Cdh1 by Cdh1:APC/C; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; Assembly of the pre-replicative complex; CDK-mediated phosphorylation and removal of Cdc6; The role of GTSE1 in G2/M progression after G2 checkpoint; MAPK6/MAPK4 signaling; UCH proteinases; Regulation of PTEN stability and activity; ABC-family proteins mediated transport; Regulation of RAS by GAPs; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of ornithine decarboxylase (ODC); Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF(Skp2)-mediated degradation of p27/p21; Degradation of beta-catenin by the destruction complex; Autodegradation of the E3 ubiquitin ligase COP1; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of DVL; Hedgehog ligand biogenesis; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; GLI3 is processed to GLI3R by the proteasome; NIK-->noncanonical NF-kB signaling; Orc1 removal from chromatin; G2/M Checkpoints; Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; KEAP1-NFE2L2 pathway; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Proteasome assembly; Degradation of CRY and PER proteins | 0.491148955876067 | 0.289331214816837 | 6584.079952397455 | 86687.12476365903 | 270188.17250437237 | 3.718763972515232 | 1.6400748843538806 |
| Q8BFY9 | Transportin-1 [OS=Mus musculus] | 24.518 | transport | nucleus;other cell component | other molecular function | 238799 | ENSMUSG00000009470 | Tnpo1 | mmu:238799; Q8BFY9; Q8C0S3; Q8K2E7 | Intraflagellar transport; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 1.70336894001643E-17 | 1.50457038391225E-17 | 42596.16543089133 | 437976.68557784334 | 3.3620586062808457 | |||
| Q5XJY5 | Coatomer subunit delta [OS=Mus musculus] | 24.06 | transport;developmental processes;other biological processes | other membranes;ER/Golgi | 213827 | ENSMUSG00000032096 | Arcn1 | mmu:213827; Q5XJY5; Q91W48 | COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic | 0.830732632556162 | 0.666244110962191 | 86104.0643165832 | 367300.86546427966 | 1134222.4794765313 | 2.092809052490848 | 1.626669454297807 | ||
| Q9R045 | Angiopoietin-related protein 2 [OS=Mus musculus] | 24.014 | stress response | 26360 | ENSMUSG00000004105 | Angptl2 | mmu:26360; Q8BM09; Q9R045 | 0.991639536226218 | 0.655383946448376 | 169054.967616806 | 599340.8417771404 | 413838.0000265217 | 1.8258842790719967 | -0.5343105644846587 | ||||
| O09061 | Proteasome subunit beta type-1 [OS=Mus musculus] | 23.971 | protein metabolism;other metabolic processes | cytosol;nucleus;other cell component | 19170 | ENSMUSG00000014769 | Psmb1 | mmu:19170; O09061; Q62038; Q62039 | Proteasome degradation | FCERI mediated NF-kB activation; Downstream TCR signaling; Neutrophil degranulation; Activation of NF-kappaB in B cells; Neddylation; Asymmetric localization of PCP proteins; Degradation of AXIN; Hedgehog 'on' state; Ub-specific processing proteases; Regulation of RUNX3 expression and activity; Antigen processing: Ubiquitination & Proteasome degradation; Autodegradation of Cdh1 by Cdh1:APC/C; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; Assembly of the pre-replicative complex; CDK-mediated phosphorylation and removal of Cdc6; The role of GTSE1 in G2/M progression after G2 checkpoint; MAPK6/MAPK4 signaling; UCH proteinases; Regulation of PTEN stability and activity; ABC-family proteins mediated transport; Regulation of RAS by GAPs; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Degradation of CDH1; Regulation of ornithine decarboxylase (ODC); Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF(Skp2)-mediated degradation of p27/p21; Degradation of beta-catenin by the destruction complex; Autodegradation of the E3 ubiquitin ligase COP1; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of DVL; Hedgehog ligand biogenesis; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; GLI3 is processed to GLI3R by the proteasome; NIK-->noncanonical NF-kB signaling; Orc1 removal from chromatin; G2/M Checkpoints; Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Proteasome assembly; Antigen processing: Ub, ATP-independent proteasomal degradation; Degradation of CRY and PER proteins | 1.70336894001643E-17 | 1.50457038391225E-17 | 331047.8299171 | 739965.9396004084 | 1.1604191922475182 | |||
| P63328 | Protein phosphatase 3 catalytic subunit alpha [OS=Mus musculus] | 23.901 | cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component | other molecular function | 19055 | ENSMUSG00000028161 | Ppp3ca | B2RRX2; mmu:19055; P12816; P20652; P63328; Q3UCU1; Q64135 | Mitochondrial gene expression; MicroRNAs in cardiomyocyte hypertrophy; Alzheimer's disease; Serotonin and anxiety; G protein signaling pathways; Spinal cord injury; Mapk signaling pathway | FCERI mediated Ca+2 mobilization; Ca2+ pathway; Calcineurin activates NFAT; CLEC7A (Dectin-1) induces NFAT activation | 1.70336894001643E-17 | 1.50457038391225E-17 | 146574.59701563398 | 746620.9029821403 | 2.348740809752781 | ||
| P53996 | CCHC-type zinc finger nucleic acid binding protein [OS=Mus musculus] | 23.881 | DNA metabolism;other metabolic processes;other biological processes | cytosol;ER/Golgi;nucleus | nucleic acid binding activity;other molecular function | 12785 | ENSMUSG00000030057 | Cnbp | mmu:12785; P53996; Q80Y06; Q8BP23 | 0.846133335665565 | 23492.2860852304 | 116533.00524494537 | 375038.6705875047 | 2.3104796052699337 | 1.6863007385684958 | |||
| Cont_Q2KIF2 | Leucine-rich alpha-2-glycoprotein 1 OS=Bos taurus OX=9913 GN=LRG1 PE=2 SV=1 | 23.876 | 514663 | LRG1 | bta:514663; Q2KIF2 | 0.633685073416418 | 0.568768408383422 | 1024150.4306515454 | 1111630.2463366345 | 993286.4057327844 | 0.11824935567005727 | -0.16239532269818918 | ||||||
| Q6ZWX6 | Eukaryotic translation initiation factor 2 subunit 1 [OS=Mus musculus] | 23.832 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes | cytosol;mitochondrion;nucleus;other cell component | translation activity;nucleic acid binding activity;other molecular function | 13665 | ENSMUSG00000021116 | Eif2s1 | mmu:13665; Q3TIQ0; Q6ZWX6 | Translation factors | L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; ABC-family proteins mediated transport; Recycling of eIF2:GDP; Cellular response to mitochondrial stress; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; PERK regulates gene expression | 0.735853267668447 | 0.819280225722906 | 47409.48977902557 | 322154.65063389536 | 1062368.5359682364 | 2.7645056497221154 | 1.721458997507612 |
| P63087 | Serine/threonine-protein phosphatase PP1-gamma catalytic subunit [OS=Mus musculus] | 23.719 | protein metabolism;other metabolic processes;developmental processes;other biological processes | plasma membrane;other membranes;cytoskeleton;mitochondrion;nucleus;other cell component | other molecular function | 19047 | ENSMUSG00000004455 | Ppp1cc | mmu:19047; O09186; O09189; P37139; P63087; Q64679 | Insulin signaling | Separation of Sister Chromatids; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; RAF activation | 1.70336894001643E-17 | 1.50457038391225E-17 | 51790.7720866021 | 156371.113725358 | 1.5942070585359132 | ||
| Q5SUR0 | Phosphoribosylformylglycinamidine synthase [OS=Mus musculus] | 23.646 | other metabolic processes;other biological processes | other cell component | other molecular function | 237823 | ENSMUSG00000020899 | Pfas | A4FUJ6; mmu:237823; Q5SUR0; Q6A080 | Purine metabolism | Purine ribonucleoside monophosphate biosynthesis | 1.70336894001643E-17 | 1.50457038391225E-17 | 72560.81350187707 | 508836.4164225177 | 2.8099393895933895 | ||
| P10639 | Thioredoxin [OS=Mus musculus] | 23.642 | other metabolic processes;stress response;other biological processes | non-structural extracellular;cytosol;nucleus;other cell component | other molecular function | 22166 | ENSMUSG00000028367 | Txn | mmu:22166; P10639; Q52KC4; Q9D8R0 | Oxidative stress and redox pathway | TP53 Regulates Metabolic Genes; Interconversion of nucleotide di- and triphosphates; Detoxification of Reactive Oxygen Species; Oxidative Stress Induced Senescence; Protein repair; The NLRP3 inflammasome | 1.70336894001643E-17 | 1.50457038391225E-17 | 57907.202863735205 | 2570610.053803857 | 1.0142883049799995E7 | 5.472224157420315 | 1.980285103836721 |
| O55234 | Proteasome subunit beta type-5 [OS=Mus musculus] | 23.622 | protein metabolism;other metabolic processes;stress response | cytosol;cytoskeleton;nucleus;other cell component | other molecular function | 19173 | ENSMUSG00000022193 | Psmb5 | mmu:19173; O55234; Q3UZI1; Q91X53; Q9CWR4; Q9R1P2 | Proteasome degradation | FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Neddylation; Asymmetric localization of PCP proteins; Degradation of AXIN; Hedgehog 'on' state; Ub-specific processing proteases; Regulation of RUNX3 expression and activity; Antigen processing: Ubiquitination & Proteasome degradation; Autodegradation of Cdh1 by Cdh1:APC/C; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; Assembly of the pre-replicative complex; CDK-mediated phosphorylation and removal of Cdc6; The role of GTSE1 in G2/M progression after G2 checkpoint; MAPK6/MAPK4 signaling; UCH proteinases; Regulation of PTEN stability and activity; ABC-family proteins mediated transport; Regulation of RAS by GAPs; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Degradation of CDH1; Regulation of ornithine decarboxylase (ODC); Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF(Skp2)-mediated degradation of p27/p21; Degradation of beta-catenin by the destruction complex; Autodegradation of the E3 ubiquitin ligase COP1; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of DVL; Hedgehog ligand biogenesis; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; GLI3 is processed to GLI3R by the proteasome; NIK-->noncanonical NF-kB signaling; Orc1 removal from chromatin; G2/M Checkpoints; Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Proteasome assembly; Antigen processing: Ub, ATP-independent proteasomal degradation; Degradation of CRY and PER proteins | 1.70336894001643E-17 | 1.50457038391225E-17 | 268564.55243958364 | 791046.598156523 | 1.5584937845026732 | ||
| Q9R1B9 | Slit homolog 2 protein [OS=Mus musculus] | 23.597 | cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes | non-structural extracellular;plasma membrane;other membranes | signal transduction activity or receptor binding;other molecular function | 20563 | ENSMUSG00000031558 | Slit2 | E9QKB4; mmu:20563; Q9R1B9; Q9Z166 | Spinal cord injury; Robo4 and VEGF signaling pathways crosstalk; GDNF/RET signaling axis | Regulation of expression of SLITs and ROBOs; Role of ABL in ROBO-SLIT signaling; SLIT2:ROBO1 increases RHOA activity | 0.85150269730134 | 0.57353382308527 | 144653.47556366233 | 504653.99573711865 | 189350.95537559534 | 1.8026935894729001 | -1.4142318761380286 |
| Q7TQI3 | Ubiquitin thioesterase OTUB1 [OS=Mus musculus] | 23.59 | protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes | other cell component | enzyme regulator activity;other molecular function | 107260 | ENSMUSG00000024767 | Otub1 | mmu:107260; Q3ULV9; Q3V408; Q7TQI3; Q8C326; Q8R5F2 | Ovarian tumor domain proteases; Ub-specific processing proteases | 0.551971794868485 | 0.768775894963893 | 180202.8389841173 | 275346.763469635 | 911151.19811698 | 0.6116279105060637 | 1.7264408267761802 | |
| Cont_Q8N1N4 | Keratin, type II cytoskeletal 78 OS=Homo sapiens OX=9606 GN=KRT78 PE=1 SV=2 | 23.582 | cell organization and biogenesis;other biological processes | cytosol;cytoskeleton | bone, tooth or skin structural activity | 196374 | ENSG00000170423 | KRT78 | A8K4D6; hsa:196374; Q5HYM7; Q7RTT2; Q8N1N4 | Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.927402296662438 | 0.546895916663803 | 204364.66724061567 | 519454.798949568 | 216212.30166676568 | 1.345852427346814 | -1.2645496072332323 | |
| Q9WV32 | Actin-related protein 2/3 complex subunit 1B [OS=Mus musculus] | 23.53 | cell organization and biogenesis | cytoskeleton;nucleus;other cell component | cytoskeletal activity | 11867 | ENSMUSG00000029622 | Arpc1b | mmu:11867; Q9CRC4; Q9WV32 | Microglia pathogen phagocytosis pathway | Regulation of actin dynamics for phagocytic cup formation; RHO GTPases Activate WASPs and WAVEs; EPHB-mediated forward signaling | 0.811642495923494 | 0.768545544322215 | 70294.44915419926 | 369729.496959206 | 708598.04390569 | 2.3949874705141587 | 0.9384973367902547 |
| Q9R0N0 | Galactokinase [OS=Mus musculus] | 23.5 | other metabolic processes | other cell component | kinase activity;other molecular function | 14635 | ENSMUSG00000020766 | Galk1 | mmu:14635; Q9JIA6; Q9R0N0 | Galactose catabolism | 0.869126988291542 | 0.805023873610961 | 36336.9761810726 | 140936.30555870233 | 419602.1930364547 | 1.9555330271920708 | 1.5739789166141473 | |
| P17225 | Polypyrimidine tract-binding protein 1 [OS=Mus musculus] | 23.429 | RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes | nucleus | nucleic acid binding activity | 19205 | ENSMUSG00000006498 | Ptbp1 | mmu:19205; P17225; Q8BGJ5; Q922I7 | mRNA processing | mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA; FGFR2 alternative splicing | 1.70336894001643E-17 | 1.50457038391225E-17 | 187534.5627017823 | 900601.0844838877 | 2.2637317055030364 | ||
| Q60932 | Non-selective voltage-gated ion channel VDAC1 [OS=Mus musculus] | 23.387 | cell-cell signaling;other metabolic processes;stress response;transport;other biological processes | plasma membrane;other membranes;mitochondrion;other cell component | transporter activity;other molecular function | 22333 | ENSMUSG00000020402 | Vdac1 | B1ASZ9; mmu:22333; Q5SVC6; Q60932 | Ub-specific processing proteases; PINK1-PRKN Mediated Mitophagy; Pyruvate metabolism | 0.255073031811733 | 0.187767203306657 | 8040.83196954362 | 237645.02187140533 | 359486.13156529766 | 4.885319588485187 | 0.5971279339904009 | |
| Q99LD8 | Putative hydrolase DDAH2 [OS=Mus musculus] | 23.358 | mitochondrion | other molecular function | 51793 | ENSMUSG00000007039 | Ddah2 | mmu:51793; Q99LD8 | 0.350024789130103 | 0.179486999742208 | 10858.94873583829 | 80227.64378696543 | 387558.07133340667 | 2.8852149858814085 | 2.2722411662895117 | |||
| P60122 | RuvB-like 1 [OS=Mus musculus] | 23.357 | cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes | other membranes;cytosol;cytoskeleton;nucleus;other cell component | other molecular function | 56505 | ENSMUSG00000030079 | Ruvbl1 | mmu:56505; O35753; P60122 | Wnt signaling pathway | DNA Damage Recognition in GG-NER; Ub-specific processing proteases; Deposition of new CENPA-containing nucleosomes at the centromere; UCH proteinases; Formation of the beta-catenin:TCF transactivating complex | 0.280532013474318 | 0.869403365646058 | 27791.063034594 | 58619.21253887124 | 335555.02873544506 | 1.0767525676639065 | 2.517103885143511 |
| Q3UJB0 | Splicing factor 3B subunit 2 [OS=Mus musculus] | 23.301 | RNA metabolism OR transcription;other metabolic processes | nucleus | 319322 | ENSMUSG00000024853 | Sf3b2 | A0A494B9S9; mmu:319322; Q3UAI4; Q3UBH2; Q3UJB0; Q3UQU5; Q80W39; Q8BL33; Q9CS24 | mRNA processing | mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway | 0.589983522490753 | 9704.888098675176 | 50515.309785829566 | 633651.5181175423 | 2.3799372116044433 | 3.6488970364123814 | ||
| Cont_Q03247 | Apolipoprotein E OS=Bos taurus OX=9913 GN=APOE PE=1 SV=1 | 23.267 | cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes | non-structural extracellular;extracellular matrix;other cytoplasmic organelle | signal transduction activity or receptor binding;transporter activity;enzyme regulator activity;other molecular function | 281004 | APOE | bta:281004; Q03247; Q3T006; Q5E967 | 0.872113329447229 | 0.7521692664391 | 262510.5739935943 | 428929.783740555 | 428330.322465678 | 0.7083659602713691 | -0.002017683881879068 | |||
| Q9WVK4 | EH domain-containing protein 1 [OS=Mus musculus] | 23.079 | cell organization and biogenesis;transport;developmental processes;other biological processes | plasma membrane;other membranes;other cytoplasmic organelle;other cell component | other molecular function | 13660 | ENSMUSG00000024772 | Ehd1 | mmu:13660; Q9WVK4 | Insulin signaling | Factors involved in megakaryocyte development and platelet production | 0.895152312190568 | 0.643351253415982 | 12578.575804582362 | 142057.70916073347 | 629052.116637799 | 3.4974366365353546 | 2.1467024230314524 |
| Q8K4Z5 | Splicing factor 3A subunit 1 [OS=Mus musculus] | 23.02 | cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes | nucleus | nucleic acid binding activity | 67465 | ENSMUSG00000002129 | Sf3a1 | mmu:67465; Q8C0M7; Q8C128; Q8C175; Q8K4Z5; Q921T3 | mRNA processing | mRNA Splicing - Major Pathway | 0.637206331155226 | 34921.6641180446 | 18896.981824299502 | 534030.1161483281 | -0.8859664797572453 | 4.820693369155197 | |
| Cont_Q05443 | Lumican OS=Bos taurus OX=9913 GN=LUM PE=1 SV=1 | 22.975 | non-structural extracellular;extracellular matrix | other molecular function | 280847 | ENSBTAG00000001745 | LUM | bta:280847; Q05443; Q3T0T2 | Keratan sulfate biosynthesis; Keratan sulfate degradation; Integrin cell surface interactions | 0.407032230614587 | 0.455985225276046 | 440810.9822402336 | 342388.07338199165 | 477204.53492650395 | -0.36452771893815294 | 0.47897530487069967 | ||
| Q9D0B6 | Protein PBDC1 [OS=Mus musculus] | 22.929 | 67683 | ENSMUSG00000031226 | Pbdc1 | B1AUP5; mmu:67683; Q8C5Z2; Q9CVL0; Q9D0B6 | 1.70336894001643E-17 | 1.50457038391225E-17 | 30780.907207444703 | 226732.96796949333 | 2.880886522488252 | |||||||
| Q62381 | Tolloid-like protein 1 [OS=Mus musculus] | 22.863 | protein metabolism;other biological processes | non-structural extracellular | other molecular function | Tll1 | Q3UTT9; Q62381; Q8BNP5 | Collagen biosynthesis and modifying enzymes; Crosslinking of collagen fibrils; Anchoring fibril formation | 6839.10615376536 | 7546.89078729356 | 14735.21745108985 | 0.14207461435270002 | 0.9653140488947394 | |||||
| Q8BMK4 | Cytoskeleton-associated protein 4 [OS=Mus musculus] | 22.797 | plasma membrane;other membranes;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component | 216197 | ENSMUSG00000046841 | Ckap4 | B2RRB4; mmu:216197; Q8BMK4; Q8BTK8; Q8R3F2 | Neutrophil degranulation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; RND2 GTPase cycle; RND3 GTPase cycle; Surfactant metabolism | 1.70336894001643E-17 | 1.50457038391225E-17 | 309650.6271871797 | 720530.6385900974 | 1.2184184101660351 | |||||
| Q60715 | Prolyl 4-hydroxylase subunit alpha-1 [OS=Mus musculus] | 22.791 | cell organization and biogenesis | mitochondrion;ER/Golgi | other molecular function | 18451 | ENSMUSG00000019916 | P4ha1 | mmu:18451; Q3TEB7; Q60715; Q80T05; Q91VJ7 | Mechanisms associated with pluripotency | Collagen biosynthesis and modifying enzymes | 1.70336894001643E-17 | 1.50457038391225E-17 | 97044.32011567673 | 387475.1997004867 | 1.9973882924725168 | ||
| P70663 | SPARC-like protein 1 [OS=Mus musculus] | 22.766 | cell adhesion;cell organization and biogenesis;signal transduction | non-structural extracellular;other cell component | other molecular function | 13602 | ENSMUSG00000029309 | Sparcl1 | E9QPH2; mmu:13602; P70663; P97810; Q99L82 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 1.70336894001643E-17 | 1.50457038391225E-17 | 228952.34780352798 | 348141.03632367234 | 0.604624519166241 | |||
| Q9D1Q6 | Endoplasmic reticulum resident protein 44 [OS=Mus musculus] | 22.724 | protein metabolism;other metabolic processes;stress response | other membranes;ER/Golgi;other cell component | other molecular function | 76299 | ENSMUSG00000028343 | Erp44 | mmu:76299; Q3TVI1; Q6A045; Q9D1Q6 | Neutrophil degranulation | 1.70336894001643E-17 | 1.50457038391225E-17 | 50412.51874680806 | 177641.34950662832 | 1.8171134940955087 | |||
| P29621 | Serine protease inhibitor A3C [OS=Mus musculus] | 22.694 | other biological processes | non-structural extracellular | enzyme regulator activity | 16625 | ENSMUSG00000066361 | Serpina3c | mmu:16625; P29621 | 0.950500494798053 | 0.757088925112533 | 24446.2262569818 | 139197.24950402626 | 151756.92245564668 | 2.5094470243665903 | 0.12463162287491637 | ||
| Q8BJY1 | 26S proteasome non-ATPase regulatory subunit 5 [OS=Mus musculus] | 22.672 | cell organization and biogenesis | other cell component | 66998 | ENSMUSG00000026869 | Psmd5 | A2AUB0; mmu:66998; Q3UFV2; Q5DU49; Q8BJY1; Q8BMA9; Q8VEE9 | Proteasome degradation | Proteasome assembly | 1.70336894001643E-17 | 1.50457038391225E-17 | 118476.06614756181 | 628070.6380100254 | 2.4063311820232154 | |||
| Cont_Q28107 | Coagulation factor V OS=Bos taurus OX=9913 GN=F5 PE=1 SV=1 | 22.593 | stress response;other biological processes | non-structural extracellular;other cell component | other molecular function | F5 | bta:280687; Q28107; Q28108 | 0.896510297029195 | 0.8304444242062 | 114329.84620412113 | 332713.62653192406 | 418050.88192421733 | 1.541078880790287 | 0.3293975926195647 | ||||
| Q9JKB3 | Y-box-binding protein 3 [OS=Mus musculus] | 22.549 | stress response;developmental processes;other biological processes | cytosol;nucleus;other cell component | nucleic acid binding activity;other molecular function | 56449 | ENSMUSG00000030189 | Ybx3 | mmu:56449; Q80WG4; Q9EQF7; Q9EQF8; Q9JKB3 | 1.70336894001643E-17 | 1.50457038391225E-17 | 103471.2361422582 | 483569.42872154666 | 2.2244932700179016 | ||||
| P29341 | Polyadenylate-binding protein 1 [OS=Mus musculus] | 22.544 | RNA metabolism OR transcription;other metabolic processes;other biological processes | cytosol;nucleus;other cell component | nucleic acid binding activity | 18458 | ENSMUSG00000022283 | Pabpc1 | mmu:18458; P29341; Q99L36 | Translation factors; mRNA processing | L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); AUF1 (hnRNP D0) binds and destabilizes mRNA; Translation initiation complex formation; Deadenylation of mRNA | 1.70336894001643E-17 | 1.50457038391225E-17 | 187130.92988156452 | 841279.8477161144 | 2.1685377522003293 | ||
| Q99020 | Heterogeneous nuclear ribonucleoprotein A/B [OS=Mus musculus] | 22.531 | DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes | cytosol;nucleus;other cell component | nucleic acid binding activity | 15384 | ENSMUSG00000020358 | Hnrnpab | mmu:15384; Q8BPE0; Q99020 | mRNA processing | 1.70336894001643E-17 | 1.50457038391225E-17 | 105520.92646069138 | 576429.2121252409 | 2.4496143134363955 | |||
| Q8K4Z3 | NAD(P)H-hydrate epimerase [OS=Mus musculus] | 22.515 | cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes | non-structural extracellular;cytosol;mitochondrion;nucleus;other cell component | other molecular function | 246703 | ENSMUSG00000028070 | Naxe | mmu:246703; Q8K4Z3 | Nicotinate metabolism | 1.70336894001643E-17 | 1.50457038391225E-17 | 135333.99944279573 | 288259.10433742934 | 1.0908418468820387 | |||
| P47880 | Insulin-like growth factor-binding protein 6 [OS=Mus musculus] | 22.514 | other biological processes | non-structural extracellular | other molecular function | 16012 | ENSMUSG00000023046 | Igfbp6 | mmu:16012; P47880; Q91X24 | Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Myometrial relaxation and contraction pathways | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | 1.70336894001643E-17 | 1.50457038391225E-17 | 73743.80220086944 | 383771.11742247996 | 2.3796524302884854 | ||
| Q8BHG1 | Nardilysin [OS=Mus musculus] | 22.48 | protein metabolism;other biological processes | other cell component | other molecular function | 230598 | ENSMUSG00000053510 | Nrdc | mmu:230598; Q8BHG1 | 1.70336894001643E-17 | 0.827678375681562 | 61250.9136835451 | 302230.316581543 | |||||
| Q9Z1D1 | Eukaryotic translation initiation factor 3 subunit G [OS=Mus musculus] | 22.471 | cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes | cytosol;translational apparatus;nucleus;other cell component | nucleic acid binding activity;other molecular function | 53356 | ENSMUSG00000070319 | Eif3g | mmu:53356; Q9R079; Q9Z1D1 | Translation factors; mRNA processing | L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition | 1.70336894001643E-17 | 1.50457038391225E-17 | 141505.96777000066 | 508570.0913199444 | 1.84558372304111 | ||
| O08538 | Angiopoietin-1 [OS=Mus musculus] | 22.468 | cell adhesion;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular;plasma membrane;other membranes;other cell component | signal transduction activity or receptor binding;other molecular function | 11600 | ENSMUSG00000022309 | Angpt1 | mmu:11600; O08538; Q6NWV7 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Comprehensive IL-17A signaling | RAF/MAP kinase cascade; Tie2 Signaling | 0.220494824964224 | 0.166409478879559 | 7707.1912784203105 | 329725.92811137135 | 553205.869371654 | 5.418918331600852 | 0.7465491249040289 |
| Q3TW96 | UDP-N-acetylhexosamine pyrophosphorylase-like protein 1 [OS=Mus musculus] | 22.45 | other molecular function | 227620 | ENSMUSG00000026956 | Uap1l1 | A1L3D3; mmu:227620; Q3TW96; Q6KAP8; Q6NVB6; Q80XP4 | 0.872113329447229 | 0.76372070519628 | 19897.9612984329 | 166632.78010045577 | 716192.3764547961 | 3.0659797083794134 | 2.1036749254450036 | ||||
| P00493 | Hypoxanthine-guanine phosphoribosyltransferase [OS=Mus musculus] | 22.438 | cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes | cytosol;other cell component | other molecular function | 15452 | ENSMUSG00000025630 | Hprt1 | mmu:15452; P00493; Q545Y2 | Purine metabolism | Azathioprine ADME; Purine salvage | 1.70336894001643E-17 | 1.50457038391225E-17 | 63025.263496882864 | 441185.76520410733 | 2.8073840934819496 | ||
| P62874 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [OS=Mus musculus] | 22.403 | cell cycle OR cell proliferation;stress response;developmental processes;signal transduction;other biological processes | plasma membrane;other membranes;other cell component | cytoskeletal activity;other molecular function | 14688 | ENSMUSG00000029064 | Gnb1 | mmu:14688; P04697; P04901; P62874 | Estrogen signaling; Chemokine signaling pathway; G protein signaling pathways; Focal adhesion: PI3K-Akt-mTOR signaling pathway; Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells | Olfactory Signaling Pathway; G alpha (q) signalling events; G alpha (12/13) signalling events; Ca2+ pathway; G beta:gamma signalling through PLC beta; Presynaptic function of Kainate receptors; G alpha (i) signalling events; ADP signalling through P2Y purinoceptor 12; Adrenaline,noradrenaline inhibits insulin secretion; Extra-nuclear estrogen signaling; Activation of the phototransduction cascade; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Vasopressin regulates renal water homeostasis via Aquaporins; Thromboxane signalling through TP receptor; High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells; Thrombin signalling through proteinase activated receptors (PARs); G-protein activation; Glucagon-type ligand receptors; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; G alpha (z) signalling events; G beta:gamma signalling through CDC42; Activation of G protein gated Potassium channels; Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits; GPER1 signaling; ADP signalling through P2Y purinoceptor 1; Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1); G beta:gamma signalling through PI3Kgamma; Prostacyclin signalling through prostacyclin receptor; G beta:gamma signalling through BTK; Sensory perception of sweet, bitter, and umami (glutamate) taste | 0.79403579468947 | 0.455244849846301 | 11583.3110208688 | 130641.3105671235 | 360726.6877661177 | 3.49549156568373 | 1.4652949935666426 |
| Q9ER72 | Cysteine--tRNA ligase, cytoplasmic [OS=Mus musculus] | 22.354 | protein metabolism;RNA metabolism OR transcription;other metabolic processes | cytosol;other cell component | nucleic acid binding activity;other molecular function | 27267 | ENSMUSG00000010755 | Cars1 | mmu:27267; O88303; Q8BP81; Q8CAY7; Q8CCE3; Q8K0S4; Q9ER68; Q9ER72 | 1.70336894001643E-17 | 1.50457038391225E-17 | 17861.26764405255 | 402271.42302805366 | 4.493262874259949 | ||||
| Q8CHH9 | Septin-8 [OS=Mus musculus] | 22.319 | other biological processes | other membranes;cytoskeleton;ER/Golgi;other cell component | other molecular function | 20362 | ENSMUSG00000018398 | Septin8 | B1AQY7; mmu:20362; Q80YC7; Q8CHH9; Q9ESF7 | 0.888389170454822 | 0.575763593175139 | 15308.68922534323 | 109607.95881334487 | 464512.6130389487 | 2.839929893072976 | 2.0833652124848143 | ||
| P15864 | Histone H1.2 [OS=Mus musculus] | 22.268 | cell organization and biogenesis;other biological processes | nucleus;other cell component | nucleic acid binding activity;other molecular function | 50708 | ENSMUSG00000036181 | H1-2 | mmu:50708; P15864 | Formation of Senescence-Associated Heterochromatin Foci (SAHF); Apoptosis induced DNA fragmentation | 1.70336894001643E-17 | 1.50457038391225E-17 | 44766.5564434612 | 1138374.8241489984 | 2038328.2261147134 | 4.668410504262292 | 0.8404107219787621 | |
| O55137 | Acyl-coenzyme A thioesterase 1 [OS=Mus musculus] | 22.26 | other metabolic processes | cytosol;other cell component | other molecular function | 26897 | ENSMUSG00000072949 | Acot1 | mmu:26897; O55137; Q549A9 | Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-3 / omega-6 fatty acid synthesis; Omega-9 fatty acid synthesis | Peroxisomal protein import; Mitochondrial protein degradation; Mitochondrial Fatty Acid Beta-Oxidation | 1.70336894001643E-17 | 1.50457038391225E-17 | 80484.18443725603 | 315103.3255235847 | 1.969047761209657 | ||
| Q64433 | 10 kDa heat shock protein, mitochondrial [OS=Mus musculus] | 22.229 | protein metabolism;other metabolic processes | mitochondrion | other molecular function | 15528 | ENSMUSG00000073676 | Hspe1 | mmu:15528; Q64433 | RHOG GTPase cycle | 0.1367389692144 | 1.50457038391225E-17 | 20207.2996090432 | 1736148.0127980735 | 3492206.3516895934 | 6.424869596818356 | 1.0082488612728073 | |
| Q9Z0J0 | NPC intracellular cholesterol transporter 2 [OS=Mus musculus] | 22.097 | cell organization and biogenesis;other metabolic processes;transport;other biological processes | ER/Golgi;other cytoplasmic organelle | transporter activity;other molecular function | 67963 | ENSMUSG00000021242 | Npc2 | mmu:67963; Q3UB23; Q9Z0J0 | Tyrobp causal network in microglia | Neutrophil degranulation; LDL clearance | 1.70336894001643E-17 | 1.50457038391225E-17 | 2083486.4049015364 | 5845710.476447937 | 1.4883786915596067 | ||
| Q9JHW2 | Omega-amidase NIT2 [OS=Mus musculus] | 22.082 | other metabolic processes | cytosol;cytoskeleton | other molecular function | 52633 | ENSMUSG00000022751 | Nit2 | mmu:52633; Q9CTG9; Q9JHW2 | Neutrophil degranulation | 1.70336894001643E-17 | 1.50457038391225E-17 | 66406.58690695773 | 218809.76586180765 | 1.7202788740449904 | |||
| P12970 | Large ribosomal subunit protein eL8 [OS=Mus musculus] | 21.996 | protein metabolism;other metabolic processes;other biological processes | other membranes;cytosol;translational apparatus;nucleus;other cell component | nucleic acid binding activity;other molecular function | 27176 | ENSMUSG00000062647 | Rpl7a | mmu:27176; P12970; Q91YM3 | Cytoplasmic ribosomal proteins | L13a-mediated translational silencing of Ceruloplasmin expression; SRP-dependent cotranslational protein targeting to membrane; Major pathway of rRNA processing in the nucleolus and cytosol; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 1.70336894001643E-17 | 1.50457038391225E-17 | 954262.2475980093 | 1979151.2353633968 | 1.0524241559396688 | ||
| Q9R1T2 | SUMO-activating enzyme subunit 1 [OS=Mus musculus] | 21.989 | protein metabolism;other metabolic processes;other biological processes | nucleus | other molecular function | 56459 | ENSMUSG00000052833 | Sae1 | mmu:56459; Q3TRG9; Q3TWJ0; Q9CSW9; Q9R1T2 | SUMO is conjugated to E1 (UBA2:SAE1); SUMO is transferred from E1 to E2 (UBE2I, UBC9) | 0.935807903280028 | 18230.9026229764 | 75187.5269492786 | 580487.4806639974 | 2.044107357544095 | 2.9486996984125486 | ||
| Q9DAR7 | m7GpppX diphosphatase [OS=Mus musculus] | 21.988 | RNA metabolism OR transcription;other metabolic processes | cytosol;mitochondrion;nucleus;other cell component | nucleic acid binding activity;other molecular function | 69305 | ENSMUSG00000032040 | Dcps | mmu:69305; Q8C5I7; Q9DAR7 | mRNA decay by 3' to 5' exoribonuclease | 0.803208252669333 | 0.591330610437306 | 19817.144488075915 | 61942.23420177107 | 316364.1560736023 | 1.6441743254544645 | 2.3525908265240814 | |
| P07141 | Macrophage colony-stimulating factor 1 [OS=Mus musculus] | 21.962 | cell cycle OR cell proliferation;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular;plasma membrane;other membranes;nucleus;other cell component | signal transduction activity or receptor binding;other molecular function | 12977 | ENSMUSG00000014599 | Csf1 | mmu:12977; P07141; Q3U395; Q8R3C8 | Cytokines and inflammatory response; Focal adhesion: PI3K-Akt-mTOR signaling pathway; IL26 signaling | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Transcriptional and post-translational regulation of MITF-M expression and activity; Other interleukin signaling | 1.70336894001643E-17 | 1.50457038391225E-17 | 3919.3022284161 | 239740.794301448 | 640656.5574109656 | 5.934734781184702 | 1.4180757465047937 |
| Q78ZA7 | Nucleosome assembly protein 1-like 4 [OS=Mus musculus] | 21.835 | cell organization and biogenesis | nucleus;other cell component | other molecular function | 17955 | ENSMUSG00000059119 | Nap1l4 | mmu:17955; O88701; Q78ZA7 | 1.70336894001643E-17 | 1.50457038391225E-17 | 24679.6718880476 | 317080.29599868297 | 3.683453108935662 | ||||
| O55029 | Coatomer subunit beta' [OS=Mus musculus] | 21.763 | transport | other membranes;cytosol;ER/Golgi | other molecular function | 50797 | ENSMUSG00000032458 | Copb2 | mmu:50797; O55029; Q3U5Z9 | COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport | 1.70336894001643E-17 | 1.50457038391225E-17 | 60625.79677308775 | 453006.33753035933 | 2.901527525616661 | |||
| P43274 | Histone H1.4 [OS=Mus musculus] | 21.736 | cell organization and biogenesis;other biological processes | nucleus;other cell component | nucleic acid binding activity;other molecular function | 50709 | ENSMUSG00000051627 | H1-4 | mmu:50709; P43274; Q5EBH3 | Formation of Senescence-Associated Heterochromatin Foci (SAHF); Apoptosis induced DNA fragmentation | 1.70336894001643E-17 | 1.50457038391225E-17 | 29940.4284402182 | 1910355.03302165 | 3733624.795497116 | 5.995602106789567 | 0.9667361704029399 | |
| Q62351 | Transferrin receptor protein 1 [OS=Mus musculus] | 21.7 | stress response;transport;signal transduction;other biological processes | non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle;other cell component | transporter activity;nucleic acid binding activity;other molecular function | 22042 | ENSMUSG00000022797 | Tfrc | mmu:22042; Q61560; Q62351 | RHOA GTPase cycle; RHOB GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHOC GTPase cycle; Cargo recognition for clathrin-mediated endocytosis; RHOG GTPase cycle; RND2 GTPase cycle; Golgi Associated Vesicle Biogenesis; RHOH GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RND1 GTPase cycle; Transferrin endocytosis and recycling | 0.0265241217848228 | 0.361284068409532 | 70609.64169817811 | 22635.86257511965 | 193224.67789603802 | -1.6412549121714957 | 3.0935971723704694 | |
| P22777 | Plasminogen activator inhibitor 1 [OS=Mus musculus] | 21.665 | stress response;developmental processes;other biological processes | other cell component | enzyme regulator activity | Serpine1 | P22777 | Platelet degranulation ; ECM proteoglycans; Dissolution of Fibrin Clot | 0.933570718645937 | 145970.63710338649 | 365029.48220453097 | 11980.7665556437 | 1.3223347990704544 | -4.929220867352408 | ||||
| Q8BH64 | EH domain-containing protein 2 [OS=Mus musculus] | 21.634 | cell organization and biogenesis;transport;other biological processes | plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component | other molecular function | 259300 | ENSMUSG00000074364 | Ehd2 | mmu:259300; Q8BH64; Q8BL28 | Insulin signaling | Factors involved in megakaryocyte development and platelet production | 1.70336894001643E-17 | 1.50457038391225E-17 | 111731.84951416956 | 463726.95339798136 | 2.0532350943316264 | ||
| P56395 | Cytochrome b5 [OS=Mus musculus] | 21.617 | other metabolic processes | other membranes;cytosol;ER/Golgi | other molecular function | 109672 | ENSMUSG00000024646 | Cyb5a | mmu:109672; P56395 | Oxidation by cytochrome P450 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane; Vitamin C (ascorbate) metabolism | 0.713834416503883 | 0.90444175026074 | 52621.7151356534 | 67220.99346549607 | 678611.4120460963 | 0.35325359251244304 | 3.3356019220667474 |
| P07091 | Protein S100-A4 [OS=Mus musculus] | 21.601 | signal transduction;other biological processes | non-structural extracellular;cytosol;nucleus;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;other molecular function | 20198 | ENSMUSG00000001020 | S100a4 | mmu:20198; P07091; P20066 | 0.590314059844477 | 0.44192333338795 | 85692.49818956794 | 8647419.237911621 | 2.1343602672489867E7 | 6.656956912992216 | 1.3034621752079065 | ||
| Q9WTX5 | S-phase kinase-associated protein 1 [OS=Mus musculus] | 21.584 | cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes | cytosol;cytoskeleton;nucleus;other cell component | other molecular function | 21402 | ENSMUSG00000036309 | Skp1 | mmu:21402; Q8C5H6; Q9WTX5 | Delta-Notch signaling pathway; Wnt signaling pathway | Neddylation; Regulation of PLK1 Activity at G2/M Transition; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Antigen processing: Ubiquitination & Proteasome degradation; Iron uptake and transport; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; SCF(Skp2)-mediated degradation of p27/p21; Degradation of beta-catenin by the destruction complex; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; GLI3 is processed to GLI3R by the proteasome; NIK-->noncanonical NF-kB signaling; Orc1 removal from chromatin; Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A; Regulation of RUNX2 expression and activity; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Cyclin D associated events in G1; MAP3K8 (TPL2)-dependent MAPK1/3 activation; Prolactin receptor signaling; SCF-beta-TrCP mediated degradation of Emi1; Regulation of BACH1 activity | 0.358024791088556 | 1.50457038391225E-17 | 8462.76817131498 | 173676.93211065137 | 709581.2444937028 | 4.3591326907378765 | 2.0305617300957373 |
| Q80V53 | Carbohydrate sulfotransferase 14 [OS=Mus musculus] | 21.577 | protein metabolism;other metabolic processes | other membranes;ER/Golgi | other molecular function | 72136 | ENSMUSG00000074916 | Chst14 | A2AQV3; mmu:72136; Q3TXA1; Q80V53; Q8R304; Q9D0P2 | Metapathway biotransformation | DS-GAG biosynthesis | 1.70336894001643E-17 | 1.50457038391225E-17 | 43253.7598578194 | 104875.43167718379 | 1.2777792985417964 | ||
| Q9CYZ2 | Tumor protein D54 [OS=Mus musculus] | 21.574 | other cell component | 66314 | ENSMUSG00000000827 | Tpd52l2 | mmu:66314; Q3TVY1; Q9CYZ2 | 1.70336894001643E-17 | 1.50457038391225E-17 | 40632.73165461896 | 453496.19465654297 | 3.480376182619946 | ||||||
| Q9QZM0 | Ubiquilin-2 [OS=Mus musculus] | 21.502 | protein metabolism;other metabolic processes;stress response;other biological processes | plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component | other molecular function | 54609 | ENSMUSG00000050148 | Ubqln2 | B1AY62; mmu:54609; Q7TSJ8; Q8VDH9; Q9QZM0 | Cargo recognition for clathrin-mediated endocytosis | 1.70336894001643E-17 | 1.50457038391225E-17 | 99838.83076680133 | 433138.29966579936 | 2.1171548026834754 | |||
| P56959 | RNA-binding protein FUS [OS=Mus musculus] | 21.471 | cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes | cytosol;nucleus;other cell component | nucleic acid binding activity;other molecular function | 233908 | ENSMUSG00000030795 | Fus | mmu:233908; P56959 | mRNA processing | mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA | 0.879626257803594 | 0.153733903739226 | 23882.64640058915 | 258295.81916509732 | 1294109.108468448 | 3.434989678386081 | 2.3248630614839603 |
| Q60972 | Histone-binding protein RBBP4 [OS=Mus musculus] | 21.422 | cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes | cytosol;nucleus;other cell component | nucleic acid binding activity;other molecular function | 19646 | ENSMUSG00000057236 | Rbbp4 | A2A875; mmu:19646; Q60972 | Mechanisms associated with pluripotency | PKMTs methylate histone lysines; Deposition of new CENPA-containing nucleosomes at the centromere; Transcriptional Regulation by E2F6; HDACs deacetylate histones; Regulation of TP53 Activity through Acetylation; RNA Polymerase I Transcription Initiation; Regulation of PTEN gene transcription; PRC2 methylates histones and DNA; Negative Regulation of CDH1 Gene Transcription; G0 and Early G1; Oxidative Stress Induced Senescence | 1.50457038391225E-17 | 90834.69499886048 | |||||
| Q8BJW6 | Eukaryotic translation initiation factor 2A [OS=Mus musculus] | 21.384 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes | other cell component | translation activity;nucleic acid binding activity;other molecular function | 229317 | ENSMUSG00000027810 | Eif2a | mmu:229317; Q05C11; Q640P8; Q8BJW6 | IL-6 signaling pathway | 1.70336894001643E-17 | 1.50457038391225E-17 | 16654.99206524945 | 375242.20926339366 | 4.4937955472863935 | |||
| P48428 | Tubulin-specific chaperone A [OS=Mus musculus] | 21.271 | cell organization and biogenesis;protein metabolism;other metabolic processes | cytoskeleton;nucleus;other cell component | cytoskeletal activity | 21371 | ENSMUSG00000042043 | Tbca | mmu:21371; P48428 | 0.723812797751432 | 0.70825207193817 | 382528.4001373107 | 973224.588980312 | 1999623.8851748633 | 1.3472059090143802 | 1.0388839887662558 | ||
| P23198 | Chromobox protein homolog 3 [OS=Mus musculus] | 21.261 | cell organization and biogenesis;stress response;other biological processes | nucleus;other cell component | nucleic acid binding activity;other molecular function | Cbx3 | P23198; Q921C4 | Transcriptional Regulation by E2F6 | 0.331593385960856 | 0.683780177733526 | 88781.8065367051 | 157476.26371872533 | 798199.7551664413 | 0.8267984185319971 | 2.34161544769002 | |||
| P47911 | Large ribosomal subunit protein eL6 [OS=Mus musculus] | 21.258 | protein metabolism;other metabolic processes | cytosol;ER/Golgi;translational apparatus;nucleus;other cell component | other molecular function | 19988 | ENSMUSG00000029614 | Rpl6 | mmu:19988; P47911; Q6P5I2; Q925C3 | Cytoplasmic ribosomal proteins | L13a-mediated translational silencing of Ceruloplasmin expression; SRP-dependent cotranslational protein targeting to membrane; Major pathway of rRNA processing in the nucleolus and cytosol; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 1.70336894001643E-17 | 1.50457038391225E-17 | 953452.0264524439 | 1757042.7283524033 | 0.8819170203585746 | ||
| Q68SA9 | A disintegrin and metalloproteinase with thrombospondin motifs 7 [OS=Mus musculus] | 21.219 | cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | other molecular function | 108153 | ENSMUSG00000032363 | Adamts7 | B2RUI8; E9QMY0; mmu:108153; Q68SA9 | O-glycosylation of TSR domain-containing proteins | ||||||||
| Q9JLV1 | BAG family molecular chaperone regulator 3 [OS=Mus musculus] | 21.215 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | cytosol;cytoskeleton;mitochondrion;nucleus;other cell component | other molecular function | 29810 | ENSMUSG00000030847 | Bag3 | mmu:29810; Q9CQL3; Q9JJC7; Q9JLV1 | Regulation of HSF1-mediated heat shock response | 1.70336894001643E-17 | 1.50457038391225E-17 | 52690.610970643094 | 253415.79965116733 | 2.2658886610278977 | |||
| P97946 | Vascular endothelial growth factor D [OS=Mus musculus] | 21.185 | cell cycle OR cell proliferation;developmental processes;signal transduction;other biological processes | non-structural extracellular;other membranes | signal transduction activity or receptor binding;other molecular function | 14205 | ENSMUSG00000031380 | Vegfd | A2AIH3; mmu:14205; P97946 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Platelet degranulation ; VEGF binds to VEGFR leading to receptor dimerization | 1.70336894001643E-17 | 1.50457038391225E-17 | 131924.69956007463 | 350885.74856001395 | 1.4112866549856806 | ||
| P46638 | Ras-related protein Rab-11B [OS=Mus musculus] | 21.18 | cell-cell signaling;other metabolic processes;transport;other biological processes | other membranes;ER/Golgi;other cytoplasmic organelle;other cell component | cytoskeletal activity;other molecular function | 19326 | ENSMUSG00000077450 | Rab11b | mmu:19326; P46638 | Focal adhesion: PI3K-Akt-mTOR signaling pathway | RAB geranylgeranylation; TBC/RABGAPs | 0.950500494798053 | 0.704547506970621 | 48179.17967938274 | 214194.77608138366 | 804095.1896943887 | 2.1524415602352676 | 1.9084430042264664 |
| Q9Z2X1 | Heterogeneous nuclear ribonucleoprotein F [OS=Mus musculus] | 21.173 | RNA metabolism OR transcription;other metabolic processes;other biological processes | cytosol;nucleus;other cell component | nucleic acid binding activity | 98758 | ENSMUSG00000042079 | Hnrnpf | mmu:98758; Q5FWK2; Q8BVU8; Q8K2U9; Q8R0E7; Q9Z2X1 | Mecp2 and associated Rett syndrome; mRNA processing | mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA | 0.743086654540196 | 0.285121389305776 | 543121.762766815 | 765679.6677860267 | 793881.2645374923 | 0.4954652749371062 | 0.05218230151956478 |
| O08810 | 116 kDa U5 small nuclear ribonucleoprotein component [OS=Mus musculus] | 21.14 | RNA metabolism OR transcription;other metabolic processes | nucleus | other molecular function | 20624 | ENSMUSG00000020929 | Eftud2 | mmu:20624; O08810 | mRNA processing | mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway | 0.386548315675074 | 196359.32627121484 | 19212.632072488 | 310943.158645851 | -3.353369039278867 | 4.016523792908255 | |
| Cont_Q3ZBS7 | Vitronectin OS=Bos taurus OX=9913 GN=VTN PE=1 SV=1 | 21.062 | cell adhesion;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes | non-structural extracellular;ER/Golgi;other cell component | signal transduction activity or receptor binding;other molecular function | 507525 | ENSBIXG00000028629; ENSBTAG00000016151 | VTN | A0A4W2E672; bta:507525; Q3ZBS7 | Inflammatory response pathway; Focal adhesion; Primary focal segmental glomerulosclerosis (FSGS) | Integrin cell surface interactions; ECM proteoglycans; Molecules associated with elastic fibres; Syndecan interactions; Regulation of Complement cascade | 0.731718271806827 | 0.986064030792852 | 1236945.9603440685 | 911563.562196319 | 3044137.8875039904 | -0.44036731105590177 | 1.7396185465272125 |
| Q03366 | C-C motif chemokine 7 [OS=Mus musculus] | 20.968 | cell organization and biogenesis;stress response;signal transduction;other biological processes | non-structural extracellular | signal transduction activity or receptor binding;other molecular function | 20306 | ENSMUSG00000035373 | Ccl7 | mmu:20306; Q03366 | Chemokine signaling pathway | 1.70336894001643E-17 | 1.50457038391225E-17 | 194079.98511904324 | 196962.61760529634 | 0.021270495321848656 | |||
| Cont_P01966 | Hemoglobin subunit alpha OS=Bos taurus OX=9913 GN=HBA PE=1 SV=2 | 20.922 | other metabolic processes;transport;other biological processes | cytosol;other cell component | other molecular function | 512439 | HBA | A3KN13; bta:100140149; bta:512439; P01966; Q3SZE0; Q9TTR9; Q9TTS0; Q9TTS1 | Cytoprotection by HMOX1; Scavenging of heme from plasma; Erythrocytes take up carbon dioxide and release oxygen; Heme signaling; Erythrocytes take up oxygen and release carbon dioxide | 0.575778947493105 | 0.369925874311504 | 3534692.349258293 | 3095589.127131287 | 2100007.90529221 | -0.19137065449153523 | -0.5598192386573427 | ||
| P14148 | Large ribosomal subunit protein uL30 [OS=Mus musculus] | 20.889 | protein metabolism;RNA metabolism OR transcription;other metabolic processes | cytosol;translational apparatus;other cell component | nucleic acid binding activity;other molecular function | 19989 | ENSMUSG00000043716 | Rpl7 | mmu:19989; P14148; Q80UR0 | Cytoplasmic ribosomal proteins; mRNA processing | L13a-mediated translational silencing of Ceruloplasmin expression; SRP-dependent cotranslational protein targeting to membrane; Major pathway of rRNA processing in the nucleolus and cytosol; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.115957291448073 | 1.50457038391225E-17 | 10715.0414805972 | 941014.6927323606 | 2116160.85369155 | 6.4565079087843555 | 1.169160139737892 |
| Q91VM5 | RNA binding motif protein, X-linked-like-1 [OS=Mus musculus] | 20.881 | cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes | non-structural extracellular;nucleus;other cell component | nucleic acid binding activity;other molecular function | 19656 | ENSMUSG00000037070 | Rbmxl1 | mmu:19656; O35479; Q91VM5 | mRNA processing | 0.828041718447237 | 0.600277477019654 | 25806.377497628 | 256168.83546562702 | 1364922.3945237724 | 3.3112954272825603 | 2.4136520474466634 | |
| Q80Z71 | Tenascin-N [OS=Mus musculus] | 20.876 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | signal transduction activity or receptor binding;other molecular function | 329278 | ENSMUSG00000026725 | Tnn | B9EHR3; mmu:329278; Q70HX0; Q80Z71 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | ECM proteoglycans | 22113.6374893293 | 16208.1396058419 | 26128.638184149666 | -0.44821784900202505 | 0.6889134281414789 | ||
| Q91YQ5 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 [OS=Mus musculus] | 20.859 | protein metabolism;other metabolic processes | other membranes;cytosol;ER/Golgi | 103963 | ENSMUSG00000030062 | Rpn1 | mmu:103963; Q3U985; Q91YQ5 | Proteasome degradation | Regulation of CDH1 posttranslational processing and trafficking to plasma membrane | 1.70336894001643E-17 | 1.50457038391225E-17 | 80582.33241945656 | 380336.6438434613 | 2.2387414739284512 | |||
| P01899 | H-2 class I histocompatibility antigen, D-B alpha chain [OS=Mus musculus] | 20.817 | other biological processes | plasma membrane;other membranes;ER/Golgi | 14964 | ENSMUSG00000073411 | H2-D1 | mmu:14964; P01899 | 1.70336894001643E-17 | 1.50457038391225E-17 | 241470.1767102543 | 742694.4888186773 | 1.6209238558664691 | |||||
| O08997 | Copper transport protein ATOX1 [OS=Mus musculus] | 20.78 | stress response;transport;other biological processes | cytosol | other molecular function | 11927 | ENSMUSG00000018585 | Atox1 | mmu:11927; O08997; Q5NCU2 | Comprehensive IL-17A signaling | Ion influx/efflux at host-pathogen interface | 1.70336894001643E-17 | 1.50457038391225E-17 | 86974.58665261287 | 680187.5032383399 | 2.9672666777841634 | ||
| P62960 | Y-box-binding protein 1 [OS=Mus musculus] | 20.754 | RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component | nucleic acid binding activity;other molecular function | 22608 | ENSMUSG00000028639 | Ybx1 | mmu:22608; P22568; P27817; P43482; P62960 | SIDS susceptibility pathways; Mecp2 and associated Rett syndrome; mRNA processing; IL-2 signaling pathway | mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA; mRNA Splicing - Minor Pathway; Interferon gamma signaling; Noncanonical activation of NOTCH3 | 1.70336894001643E-17 | 25971.1160939553 | |||||
| Q9JHI0 | Matrix metalloproteinase-19 [OS=Mus musculus] | 20.752 | protein metabolism;other metabolic processes;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes | other molecular function | 58223 | ENSMUSG00000025355 | Mmp19 | mmu:58223; Q8C360; Q9JHI0 | Matrix metalloproteinases | Degradation of the extracellular matrix | 1.70336894001643E-17 | 1.50457038391225E-17 | 95705.83882901468 | 380199.5776659763 | 1.9900780808536116 | ||
| O35737 | Heterogeneous nuclear ribonucleoprotein H [OS=Mus musculus] | 20.746 | RNA metabolism OR transcription;other metabolic processes;other biological processes | nucleus | nucleic acid binding activity | 59013 | ENSMUSG00000007850 | Hnrnph1 | mmu:59013; O35737 | Mecp2 and associated Rett syndrome; mRNA processing | mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA | 0.970558090277344 | 0.131338221944212 | 13215.42310228376 | 35376.632707877994 | 356471.6763952716 | 1.4205741182195906 | 3.332918813210205 |
A
B
C
D
E
F
G
H
I
J
K
L
M
N
O
P
Q
R
S
T
U
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
| Accession | Description | Sum PEP Score | Biological Process | Cellular Component | Molecular Function | Entrez Gene ID | Ensembl Gene ID | Gene Symbol | Gene ID | WikiPathways | Reactome Pathways | Abundance Ratio Adj. P-Value: (SQ_16h) / (LQ_16h) | Abundance Ratio Adj. P-Value: (SQ_6h) / (LQ_6h) | LQ6h_AVERAGE | LQ16h_AVERAGE | LQ24h_AVERAGE | SQ6h_AVERAGE | SQ16h_AVERAGE | FC_SQ_16_vs_LQ_16h | FC_SQ_6_vs_LQ_6h |
| P11276 | Fibronectin [OS=Mus musculus] | 867.353 | cell adhesion;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi | signal transduction activity or receptor binding;enzyme regulator activity;other molecular function | 14268 | ENSMUSG00000026193 | Fn1 | G5E8B8; mmu:14268; P11276; Q61567; Q61568; Q61569; Q64233; Q80UI4 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Inflammatory response pathway; Regulation of actin cytoskeleton; Comprehensive IL-17A signaling; Focal adhesion | ECM proteoglycans; Platelet degranulation ; Cell surface interactions at the vascular wall; Syndecan interactions; MAP2K and MAPK activation; Integrin cell surface interactions; Molecules associated with elastic fibres; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Fibronectin matrix formation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; Degradation of the extracellular matrix; Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells; MET activates PTK2 signaling; GPER1 signaling | 0.974036928885484 | 0.435823028559966 | 2.022341523870097E8 | 2.12696235413058E8 | 2.684744239015217E8 | 1.2629719382404166E8 | 2.7495824150743634E8 | 0.37041803136358886 | -0.6792040691298411 |
| P11087 | Collagen alpha-1(I) chain [OS=Mus musculus] | 797.017 | cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12842 | ENSMUSG00000001506 | Col1a1 | mmu:12842; P11087; Q53WT0; Q60635; Q61367; Q61427; Q63919; Q6PCL3; Q810J9 | Osteoblast signaling; Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Comprehensive IL-17A signaling; Focal adhesion | Cell surface interactions at the vascular wall; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ECM proteoglycans; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; GPVI-mediated activation cascade; GP1b-IX-V activation signalling; Platelet Adhesion to exposed collagen; Platelet Aggregation (Plug Formation); MET activates PTK2 signaling | 1.58880673198775E-4 | 0.0629214061377862 | 2.0798706453114033E8 | 5.92854376184685E8 | 5.928171930552336E8 | 5.973622733379293E7 | 8.428319253806247E7 | -2.814360908962058 | -1.799815773091645 |
| Q01149 | Collagen alpha-2(I) chain [OS=Mus musculus] | 773.662 | cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12843 | ENSMUSG00000029661 | Col1a2 | mmu:12843; Q01149; Q8CGA5 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Focal adhesion | Crosslinking of collagen fibrils; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; ECM proteoglycans; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; GPVI-mediated activation cascade; GP1b-IX-V activation signalling; Platelet Adhesion to exposed collagen; Platelet Aggregation (Plug Formation); MET activates PTK2 signaling | 0.0150838661305169 | 0.0347692006632991 | 1.7308392932505235E8 | 3.475967473053053E8 | 4.108532345040607E8 | 4.271481968913147E7 | 9.036410240893161E7 | -1.9435929082069783 | -2.018663180583724 |
| P08121 | Collagen alpha-1(III) chain [OS=Mus musculus] | 695.631 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | extracellular matrix;other cell component | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 12825 | ENSMUSG00000026043 | Col3a1 | mmu:12825; P08121; Q61429; Q9CRN7 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Focal adhesion | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ECM proteoglycans; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; MET activates PTK2 signaling | 0.00738207855214502 | 0.394949139624895 | 6.282890624937943E7 | 2.8394661715058166E8 | 2.9634851273536664E8 | 3.0365458724261332E7 | 6.6157215803336866E7 | -2.101649298329015 | -1.0489973014656733 |
| Q9QXS1 | Plectin [OS=Mus musculus] | 659.702 | cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component | cytoskeletal activity;other molecular function | 18810 | ENSMUSG00000022565 | Plec | E9QN87; mmu:18810; Q6S384; Q6S389; Q6S394; Q9CS65; Q9QUT2; Q9QXQ8; Q9QXQ9; Q9QXR0; Q9QXR1; Q9QXR2; Q9QXR3; Q9QXR4; Q9QXR5; Q9QXR6; Q9QXR7; Q9QXR8; Q9QXR9; Q9QXS0; Q9QXS1; Q9QXS2; Q9QXS3 | Alpha 6 beta 4 integrin signaling pathway; EGFR1 signaling pathway | Type I hemidesmosome assembly; Caspase-mediated cleavage of cytoskeletal proteins | 0.850917681937748 | 0.702330308974487 | 4599273.114185064 | 1.6676006673579365E7 | 4.0231485359460294E7 | 1.01501282886872E7 | 4.28490141732006E7 | 1.3614881580387048 | 1.1420201863832355 |
| P08122 | Collagen alpha-2(IV) chain [OS=Mus musculus] | 526.992 | RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix | extracellular structural activity | 12827 | ENSMUSG00000031503 | Col4a2 | mmu:12827; P08122; Q3B7C2; Q3TPV9; Q61375; Q66JS5; Q6RCT6; Q6RCT7; Q6U9X1; Q8BPI9; Q8BPK3; Q91VI3 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Focal adhesion | Laminin interactions; Signaling by PDGF; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions | 0.979628232635575 | 0.959159975702413 | 1.3981747232493034E7 | 5.0194805286054574E7 | 9.68446240720073E7 | 1.701609057115766E7 | 5.972856146483746E7 | 0.25088290969327387 | 0.2833549587108298 |
| Q3U962 | Collagen alpha-2(V) chain [OS=Mus musculus] | 518.514 | cell organization and biogenesis;developmental processes;other biological processes | extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12832 | ENSMUSG00000026042 | Col5a2 | mmu:12832; Q3TVR2; Q3U962; Q3UHK7; Q3UTT4; Q3V1J6; Q61431; Q7TMS0; Q80VS8 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions | 0.0769666553885184 | 0.453486790198347 | 1.5753424919239333E7 | 4.592471970087584E7 | 6.332560400994137E7 | 1.0471363011153279E7 | 2.1079551940947264E7 | -1.1234267140336414 | -0.5892162722872147 |
| Q05793 | Basement membrane-specific heparan sulfate proteoglycan core protein [OS=Mus musculus] | 507.28 | cell organization and biogenesis;transport;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;ER/Golgi | other molecular function | 15530 | Hspg2 | mmu:15530; Q05793 | 0.208890689478245 | 0.285967432697218 | 2.1355561683383033E7 | 4.109385814368304E7 | 4.603208822128189E7 | 8244737.341084313 | 1.8998181152407136E7 | -1.1130614814811859 | -1.373066405061947 | |||
| Q61554 | Fibrillin-1 [OS=Mus musculus] | 499.202 | cell adhesion;other metabolic processes;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 14118 | ENSMUSG00000027204 | Fbn1 | A2AQ53; mmu:14118; Q60826; Q61554 | Comprehensive IL-17A signaling | Integrin cell surface interactions; Degradation of the extracellular matrix; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; TGF-beta receptor signaling activates SMADs; Molecules associated with elastic fibres | 0.087482121441914 | 0.0455630470425967 | 2.17735814942991E7 | 5.216417896597137E7 | 4.48746709774994E7 | 5145074.9913376765 | 2.082557122129057E7 | -1.3247033834999922 | -2.0813147229720497 |
| Q8BTM8 | Filamin-A [OS=Mus musculus] | 493.069 | cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;other molecular function | 192176 | ENSMUSG00000031328 | Flna | B7FAV0; O54934; Q7TQI1; Q8BLK1; Q8BTM8; Q8BTN7; Q8VHX5; Q8VHX8; Q99KQ2 | Mapk signaling pathway; Focal adhesion | Platelet degranulation ; Cell-extracellular matrix interactions; RHO GTPases activate PAKs; GP1b-IX-V activation signalling | 0.946239447314336 | 0.904360680536565 | 4952287.405198824 | 1.1395384793048913E7 | 3.45895898091015E7 | 4296604.098486893 | 1.4686023116833666E7 | 0.36599413443703693 | -0.20489819440782575 |
| P02463 | Collagen alpha-1(IV) chain [OS=Mus musculus] | 487.707 | cell organization and biogenesis;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix | extracellular structural activity;other molecular function | 12826 | ENSMUSG00000031502 | Col4a1 | mmu:12826; P02463; Q3UHJ4; Q3UJE7; Q3UQV2; Q53X35; Q6GQS7; Q6PHB5; Q99LQ8 | Spinal cord injury; Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Laminin interactions; Signaling by PDGF; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions | 0.483508479481234 | 0.777395712279767 | 4620515.057112186 | 2.1463797748519864E7 | 4.45598479783772E7 | 8911949.32392111 | 3.3156314746725336E7 | 0.627378297898211 | 0.9476873486816851 |
| Q60847 | Collagen alpha-1(XII) chain [OS=Mus musculus] | 480.266 | cell adhesion;developmental processes | other cell component | 12816 | ENSMUSG00000032332 | Col12a1 | mmu:12816; P70322; Q60847 | Assembly of collagen fibrils and other multimeric structures; Collagen chain trimerization; Collagen degradation | 0.119424004207039 | 0.0103905836841461 | 5.1736330625803865E7 | 2.9952489655588504E7 | 5.41828161343536E7 | 1.0537780206453351E7 | 1.4629541968462234E7 | -1.033791323716814 | -2.2956067413237813 | ||
| Q8VDD5 | Myosin-9 [OS=Mus musculus] | 418.364 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;stress response;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;other molecular function | 17886 | ENSMUSG00000022443 | Myh9 | mmu:17886; Q3UHT9; Q3UHU4; Q6KAN6; Q811I2; Q8VDD5 | Primary focal segmental glomerulosclerosis (FSGS) | RHO GTPases activate PAKs; Regulation of actin dynamics for phagocytic cup formation | 0.87421335771164 | 0.91728043005175 | 5176534.940650649 | 8067345.413832072 | 1.95000780331961E7 | 7844465.70271172 | 1.9759662960152034E7 | 1.2923924059140754 | 0.5996884741558165 |
| Cont_P02453 | Collagen alpha-1(I) chain OS=Bos taurus OX=9913 GN=COL1A1 PE=1 SV=3 | 414.689 | cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | 282187 | ENSBTAG00000013103 | COL1A1 | bta:282187; P02453; Q3MHM2 | Inflammatory response pathway; Osteoblast signaling; Focal adhesion | Fibronectin matrix formation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Collagen degradation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; Collagen chain trimerization; GPVI-mediated activation cascade; Platelet Aggregation (Plug Formation); Platelet Adhesion to exposed collagen; GP1b-IX-V activation signalling | 0.067749585016969 | 0.108042253370914 | 3262486.7198886867 | 3910059.36528234 | 2611857.205675677 | 1102058.9569362423 | 924822.5329095138 | -2.079942057680374 | -1.5657706231882562 |
| Cont_P02769 | Albumin OS=Bos taurus OX=9913 GN=ALB PE=1 SV=4 | 390.555 | stress response;other biological processes | non-structural extracellular;other cell component | nucleic acid binding activity;other molecular function | 280717 | ALB | A5PJX3; bta:280717; O02787; P02769; P04277; Q3SZR2 | 0.946568086066385 | 0.846117085258013 | 2.9099571807541137E9 | 2.4034772237737E9 | 1.9319093626168566E9 | 2.38097622607819E9 | 2.6841204207378564E9 | 0.15932626621701673 | -0.28944470896955565 | |||
| P01027 | Complement C3 [OS=Mus musculus] | 388.541 | cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular;other cell component | signal transduction activity or receptor binding;enzyme regulator activity | 12266 | ENSMUSG00000024164 | C3 | mmu:12266; P01027; Q61370; Q80XP1 | Complement activation, classical pathway; Tyrobp causal network in microglia; Comprehensive IL-17A signaling | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade; Neutrophil degranulation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; G alpha (i) signalling events; Peptide ligand-binding receptors; Alternative complement activation; Activation of C3 and C5 | 0.939492000987438 | 0.413470300505934 | 1.6657146132333001E7 | 4.4549110086954266E7 | 9.444511683907779E7 | 3.6733221642207734E7 | 8.026680998659676E7 | 0.8494069495035886 | 1.1409441863835255 |
| Cont_Q7SIH1 | Alpha-2-macroglobulin OS=Bos taurus OX=9913 GN=A2M PE=1 SV=2 | 370.864 | non-structural extracellular | enzyme regulator activity;other molecular function | 513856 | ENSBTAG00000018137 | A2M | A8E647; bta:513856; Q7SIH1 | IL-6 signaling pathway | 0.944154202827561 | 0.671798309985569 | 7.564994624258716E7 | 7.018676700369896E7 | 1.6376415758098435E8 | 5.23492843648457E7 | 8.250822323914327E7 | 0.23333886293366002 | -0.5311692421661273 | ||
| Cont_Q29443 | Serotransferrin OS=Bos taurus OX=9913 GN=TF PE=2 SV=1 | 343.183 | stress response;transport;other biological processes | non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle | other molecular function | 280705 | TF | bta:280705; Q0IIK2; Q29443 | 0.902231721267411 | 0.506704636011438 | 2.32106703986673E8 | 1.5606409762411097E8 | 1.0552713551758902E8 | 1.3567523181654152E8 | 1.6257112433260167E8 | 0.058932345527944796 | -0.7746308192572785 | |||
| Cont_P07589 | Fibronectin OS=Bos taurus OX=9913 GN=FN1 PE=1 SV=4 | 337.517 | cell adhesion;cell organization and biogenesis;stress response;developmental processes;other biological processes | non-structural extracellular | signal transduction activity or receptor binding;other molecular function | FN1 | P07589 | 0.553450172742796 | 0.35834247597224 | 835883.8306505851 | 952169.9232567847 | 590914.7645248 | 482619.7682389803 | 602598.7403397557 | -0.6600214012146457 | -0.7924154436110592 | ||||
| Q80X90 | Filamin-B [OS=Mus musculus] | 335.882 | cell organization and biogenesis;stress response;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 286940 | ENSMUSG00000025278 | Flnb | E9QNV9; mmu:286940; Q80X90; Q8VHX4; Q8VHX7; Q99KY3 | ISG15 antiviral mechanism | 0.936411452199724 | 0.872448101434609 | 2351112.5534752235 | 6048828.490809467 | 1.7547066707595836E7 | 1865154.4144755967 | 7592568.170254476 | 0.3279322018375229 | -0.3340485310994022 | |
| Cont_P35527 | Keratin, type I cytoskeletal 9 OS=Homo sapiens OX=9606 GN=KRT9 PE=1 SV=3 | 310.424 | cell organization and biogenesis;other biological processes | cytosol;cytoskeleton | cytoskeletal activity | 3857 | ENSG00000171403 | KRT9 | hsa:3857; O00109; P35527; Q0IJ47; Q14665 | Formation of the cornified envelope | 0.873609880131656 | 0.516448827835279 | 3.250630567014273E7 | 4.1318104811136335E7 | 3.4478974092312835E7 | 9.369998400542612E7 | 5.1433611479478456E7 | 0.31593737616513196 | 1.5273291980404673 | |
| Cont_P04264 | Keratin, type II cytoskeletal 1 OS=Homo sapiens OX=9606 GN=KRT1 PE=1 SV=6 | 306.58 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;other molecular function | 3848 | ENSG00000167768 | KRT1 | B2RA01; hsa:3848; P04264; P85925; P86104; Q14720; Q6GSJ0; Q9H298 | Corticotropin-releasing hormone signaling | Formation of the cornified envelope; Neutrophil degranulation; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.873609880131656 | 0.254077056479593 | 1.3414412508194733E8 | 1.6528138436319932E8 | 1.1322276749996448E8 | 4.476405570139613E8 | 1.7631437693719265E8 | 0.09322587587347089 | 1.738556880584629 |
| P06909 | Complement factor H [OS=Mus musculus] | 292.01 | cell adhesion;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes | non-structural extracellular;plasma membrane;other membranes;mitochondrion;other cell component | other molecular function | 12628 | ENSMUSG00000026365 | Cfh | mmu:12628; P06909; Q6NZK3 | Regulation of Complement cascade | 0.678323397545056 | 0.750662231008662 | 1.0566840244224759E7 | 1.036081717107911E7 | 1.3701110968154365E7 | 8439848.284125684 | 2.9357524779450033E7 | 1.502592540643395 | -0.3242550682599269 | |
| P16546 | Spectrin alpha chain, non-erythrocytic 1 [OS=Mus musculus] | 291.854 | cell organization and biogenesis | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 20740 | ENSMUSG00000057738 | Sptan1 | A3KGU6; A3KGU8; P16546; Q8K380; Q9CT05 | FAS pathway and stress induction of HSP regulation | Neutrophil degranulation; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Interaction between L1 and Ankyrins; COPI-mediated anterograde transport; RHOU GTPase cycle; RHOV GTPase cycle; Caspase-mediated cleavage of cytoskeletal proteins | 0.929383260195332 | 0.870511801558508 | 1427277.73205798 | 3976922.979229001 | 9978258.42723309 | 2263434.85725903 | 8138355.29233573 | 1.0330846429966014 | 0.6652476915056309 |
| Cont_P13645 | Keratin, type I cytoskeletal 10 OS=Homo sapiens OX=9606 GN=KRT10 PE=1 SV=6 | 286.713 | cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes | plasma membrane;cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;other molecular function | 3858 | ENSG00000186395 | KRT10 | hsa:3858; P13645; Q14664; Q8N175 | Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.829734761131295 | 0.246231694954624 | 9.409796786421584E7 | 1.13950700113199E8 | 6.71694026550819E7 | 3.19749190691826E8 | 1.0914077913761683E8 | -0.06221954053344878 | 1.7647052355257151 | |
| Cont_P35908 | Keratin, type II cytoskeletal 2 epidermal OS=Homo sapiens OX=9606 GN=KRT2 PE=1 SV=2 | 284.975 | cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes | plasma membrane;cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;cytoskeletal activity | 3849 | ENSG00000172867 | KRT2 | hsa:3849; P35908; Q4VAQ2 | Formation of the cornified envelope | 0.912218866069753 | 0.309041843038519 | 2.9357809740500167E7 | 3.415287514761583E7 | 1.8123682357997265E7 | 7.640800383787991E7 | 3.617272663897294E7 | 0.0828953136099207 | 1.3799794314161524 | |
| Q62059 | Versican core protein [OS=Mus musculus] | 279.715 | cell adhesion;developmental processes | non-structural extracellular;extracellular matrix;other cell component | other molecular function | Vcan | Q62058; Q62059; Q9CUU0 | ECM proteoglycans; Glycosaminoglycan-protein linkage region biosynthesis; CS/DS degradation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; CS-GAG biosynthesis; DS-GAG biosynthesis | 0.854305439376382 | 0.478009151463064 | 9.037034497028168E7 | 9.467651077277745E7 | 6.45815395615126E7 | 5.89459061512507E7 | 9.510262638582683E7 | 0.006478645904816274 | -0.6164578097523755 | |||
| P10493 | Nidogen-1 [OS=Mus musculus] | 275.191 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | other molecular function | 18073 | ENSMUSG00000005397 | Nid1 | mmu:18073; P10493; Q3TKX9; Q8BQI3; Q8C3U8; Q8C9P6 | Laminin interactions; Degradation of the extracellular matrix | 0.013229256333524 | 1.0740690550749E-5 | 1.2120394496125467E8 | 1.2671518083095133E8 | 1.3280012723821335E8 | 9146738.193898173 | 3.1971627034095198E7 | -1.9867253039502062 | -3.7280354888144775 | |
| O88207 | Collagen alpha-1(V) chain [OS=Mus musculus] | 275.025 | cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes | extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12831 | ENSMUSG00000026837 | Col5a1 | A3KGE3; mmu:12831; O88207; Q3UG94; Q6F6B0 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | ECM proteoglycans; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; MET activates PTK2 signaling | 0.189625712887896 | 0.302671730722046 | 3577832.3612721 | 8562033.320911517 | 1.35263273373913E7 | 1386447.3981625708 | 3098568.0509616495 | -1.4663517968660993 | -1.367692910200405 |
| P37889 | Fibulin-2 [OS=Mus musculus] | 269.894 | other biological processes | non-structural extracellular | other molecular function | 14115 | ENSMUSG00000064080 | Fbln2 | G5E8B3; mmu:14115; P37889; Q9WUI2 | Molecules associated with elastic fibres | 0.453005417011507 | 0.290132264062119 | 6.556805587417743E7 | 8.021475911820169E7 | 7.423633042764436E7 | 3.00676966042863E7 | 4.93487108032657E7 | -0.700855313955825 | -1.1247787672414093 | |
| Q8VHX6 | Filamin-C [OS=Mus musculus] | 249.498 | cell organization and biogenesis;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity | 68794 | ENSMUSG00000068699 | Flnc | B2RY80; B9EKT2; mmu:68794; Q6PAI6; Q8VHX6; Q9JJ38 | Cell-extracellular matrix interactions | 0.976873891151678 | 0.933437821008547 | 1016453.1391661359 | 2089599.8263247435 | 6137929.999733508 | 1136666.5742976035 | 4459384.47065665 | 1.093617906439173 | 0.1612654161431754 | |
| Q04857 | Collagen alpha-1(VI) chain [OS=Mus musculus] | 248.981 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component | other molecular function | 12833 | ENSMUSG00000001119 | Col6a1 | mmu:12833; Q04857 | ECM proteoglycans; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Signaling by PDGF; NCAM1 interactions | 0.0353343473113635 | 0.115965329440656 | 5.0068940213435836E7 | 6.914260176814564E7 | 6.089353622953653E7 | 1.4473176745930666E7 | 1.9886194591010433E7 | -1.7978076624001023 | -1.7905343022837863 | |
| Cont_Q2UVX4 | Complement C3 OS=Bos taurus OX=9913 GN=C3 PE=1 SV=2 | 247.154 | cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular;other cell component | signal transduction activity or receptor binding;enzyme regulator activity | 280677 | ENSBTAG00000017280 | C3 | bta:280677; Q2KIZ4; Q2UVX4 | Complement and coagulation cascades; Complement activation, classical pathway | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Neutrophil degranulation; Peptide ligand-binding receptors; G alpha (i) signalling events; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade; Alternative complement activation; Activation of C3 and C5 | 0.87421335771164 | 0.591028379533681 | 1.84550126489547E7 | 1.5291804049274266E7 | 1.004110180479193E7 | 1.196234797265725E7 | 1.6127794015790733E7 | 0.07679049940163296 | -0.6255121365240285 |
| Q62261 | Spectrin beta chain, non-erythrocytic 1 [OS=Mus musculus] | 244.684 | cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 20742 | ENSMUSG00000020315 | Sptbn1 | A2AFU1; mmu:20742; Q3TEM7; Q5SQL8; Q5SQL9; Q62261; Q9QWJ7 | COPI-mediated anterograde transport; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; RHOU GTPase cycle; Interaction between L1 and Ankyrins; RHOV GTPase cycle | 0.937876734191067 | 0.664971370235365 | 920886.7046363313 | 2921004.358024217 | 7076390.486598223 | 2299979.2063157237 | 6417771.720584608 | 1.1356079634194152 | 1.3205252384353656 | |
| Q640N1 | Adipocyte enhancer-binding protein 1 [OS=Mus musculus] | 239.707 | protein metabolism;other biological processes | nucleus;other cell component | nucleic acid binding activity;other molecular function | 11568 | ENSMUSG00000020473 | Aebp1 | mmu:11568; O88442; Q3TVV5; Q3TWA7; Q3TX56; Q3TXB2; Q5NCI9; Q61281; Q640N1 | 0.534291750451691 | 0.145805028390539 | 3.9556778473622136E7 | 4.1143769603117764E7 | 4.694818678152809E7 | 1.8648394999714002E7 | 3.1901344171106894E7 | -0.3670567664350577 | -1.0848734687320578 | ||
| P57780 | Alpha-actinin-4 [OS=Mus musculus] | 239.42 | cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes | cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 60595 | ENSMUSG00000054808 | Actn4 | mmu:60595; P57780 | Primary focal segmental glomerulosclerosis (FSGS) | Platelet degranulation | 0.921882153462399 | 0.968364585136618 | 4580996.01302682 | 9830280.285985528 | 3.01659424163415E7 | 4440337.50144963 | 1.1658414413951913E7 | 0.24606713307090775 | -0.044991970039703705 |
| Q7TPR4 | Alpha-actinin-1 [OS=Mus musculus] | 235.529 | cell adhesion;cell organization and biogenesis;other biological processes | plasma membrane;other membranes;cytoskeleton;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function | 109711 | ENSMUSG00000015143 | Actn1 | mmu:109711; Q7TPR4 | Regulation of actin cytoskeleton; Integrin-mediated cell adhesion; Focal adhesion | Platelet degranulation ; RHOF GTPase cycle; RHOBTB2 GTPase cycle; RHOD GTPase cycle; Regulation of cytoskeletal remodeling and cell spreading by IPP complex components | 0.974207409660283 | 0.837231569641376 | 2525588.7379033365 | 6210475.170240924 | 1.99706831247943E7 | 3717490.65968503 | 9946958.94260729 | 0.679551866892813 | 0.5577093849474224 |
| P02468 | Laminin subunit gamma-1 [OS=Mus musculus] | 230.882 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | Lamc1 | P02468 | 0.3041568870489 | 0.368062651583427 | 7327169.184632126 | 1.61740059690847E7 | 2.6285654209548533E7 | 3246292.9185144133 | 7951596.802164167 | -1.0243605391840713 | -1.1744627453696188 | ||||
| Q91ZX7 | Prolow-density lipoprotein receptor-related protein 1 [OS=Mus musculus] | 230.497 | other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;other molecular function | 16971 | Lrp1 | mmu:16971; Q61291; Q91ZX7; Q920Y4 | Statin pathway; Wnt signaling pathway | Scavenging of heme from plasma; Retinoid metabolism and transport | 0.687557067265551 | 0.74148782464906 | 3548407.5296101067 | 7355877.025944923 | 9948732.886846773 | 2243610.9879279765 | 5724840.5342227295 | -0.3616618538572069 | -0.6613491570014096 | |
| Cont_P60712 | Actin, cytoplasmic 1 OS=Bos taurus OX=9913 GN=ACTB PE=1 SV=1 | 225.45 | cell organization and biogenesis;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component | enzyme regulator activity;cytoskeletal activity;other molecular function | 100033878; 100135470; 100173832; 101844587; 102139853; 11461; 118833809; 280979; 396526; 403580; 414396; 443052; 450133; 60; 81822 | ENSBTAG00000026199; ENSCAFG00000016020; ENSCAFG00030015381; ENSCAFG00040015695; ENSCPOG00000013467; ENSG00000075624; ENSMAUG00000008763; ENSMUSG00000029580; ENSOARG00040012985; ENSOARG00180022443; ENSOARG00185023855; ENSOARG00215030140; ENSOARG00225009314; ENSPPYG00000017336; ENSPTRG00000018890; ENSRNOG00000034254; ENSSSCG00000007585; ENSSSCG00030003451; ENSSSCG00035038792; ENSSSCG00040049462; ENSSSCG00045027458; ENSSSCG00050065025; ENSSSCG00055012597; ENSSSCG00060019124; ENSSSCG00065037921; ENSSSCG00070011353; ENSSSCG00105030144; ENSSSCG00110026965; ENSSSCG00115013637; ENSSSCG00130033784 | Actb; ACTB | A5D961; A5PKA1; bta:280979; cfa:403580; cpoc:100135470; csab:103246953; ecb:100033878; gga:396526; hsa:60; maua:101844587; mmu:11461; O18840; oas:443052; P02570; P60706; P60707; P60708; P60709; P60710; P60711; P60712; P60713; P70514; P99021; pon:100173832; ptr:450133; Q11209; Q11211; Q3SZD2; Q3TI89; Q3TVP6; Q4L0Y2; Q4R561; Q5R1X3; Q5R582; Q5R6G0; Q64316; Q6QAQ1; Q6ZWM3; Q711N9; Q71FK5; Q75MN2; Q76N69; Q8MIJ0; Q8SPX4; Q95164; Q96B34; Q96HG5; rno:81822; ssc:414396 | FAS pathway and stress induction of HSP regulation; Actin cytoskeleton regulation; Myometrial relaxation and contraction pathways; Focal adhesion; Arrhythmogenic right ventricular cardiomyopathy; Pathogenic Escherichia coli infection; Common pathways underlying drug addiction; Myometrial relaxation and contraction pathways; Focal adhesion; Fas ligand pathway and stress induction of heat shock proteins; Pathogenic Escherichia coli infection; Arrhythmogenic right ventricular cardiomyopathy; Focal adhesion; Myometrial relaxation and contraction pathways; Regulation of actin cytoskeleton; Myometrial relaxation and contraction pathways; Ebola virus infection in host; Acute viral myocarditis; Thermogenesis; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Overlap between signal transduction pathways contributing to LMNA laminopathies; Pleural mesothelioma; Regulation of actin cytoskeleton; Network map of SARS-CoV-2 signaling; Regulation of actin cytoskeleton; Regulation of actin cytoskeleton; Focal adhesion | Formation of the canonical BAF (cBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); Regulation of actin dynamics for phagocytic cup formation; EPH-ephrin mediated repulsion of cells; Formation of annular gap junctions; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; RHO GTPases Activate Formins; RHOF GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; B-WICH complex positively regulates rRNA expression; Regulation of CDH1 Function; Formation of the dystrophin-glycoprotein complex (DGC); Formation of the canonical BAF (cBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); RHO GTPases Activate WASPs and WAVEs; UCH proteinases; DNA Damage Recognition in GG-NER; Formation of the non-canonical BAF (ncBAF) complex; RHO GTPases activate IQGAPs; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Cell-extracellular matrix interactions; MAP2K and MAPK activation; Interaction between L1 and Ankyrins; RHOF GTPase cycle; DNA Damage Recognition in GG-NER; MAP2K and MAPK activation; RHO GTPases Activate Formins; Clathrin-mediated endocytosis; UCH proteinases; RHOF GTPase cycle; DNA Damage Recognition in GG-NER; EPH-ephrin mediated repulsion of cells; VEGFA-VEGFR2 Pathway; Regulation of actin dynamics for phagocytic cup formation; Adherens junctions interactions; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); RHO GTPases Activate WASPs and WAVEs; B-WICH complex positively regulates rRNA expression; Regulation of CDH1 Function; EPHB-mediated forward signaling; Formation of the non-canonical BAF (ncBAF) complex; Formation of the canonical BAF (cBAF) complex; Formation of annular gap junctions; RHO GTPases activate IQGAPs; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; RHO GTPases Activate WASPs and WAVEs; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RHO GTPases activate IQGAPs; RHO GTPases Activate Formins; RHOF GTPase cycle; Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs); B-WICH complex positively regulates rRNA expression; Signaling by BRAF and RAF1 fusions; UCH proteinases; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; VEGFA-VEGFR2 Pathway; Formation of the dystrophin-glycoprotein complex (DGC); Factors involved in megakaryocyte development and platelet production; Regulation of MITF-M-dependent genes involved in pigmentation; Formation of the canonical BAF (cBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); EPH-ephrin mediated repulsion of cells; HATs acetylate histones; Interaction between L1 and Ankyrins; Prefoldin mediated transfer of substrate to CCT/TriC; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Adherens junctions interactions; Regulation of CDH1 Function; Formation of the non-canonical BAF (ncBAF) complex; DNA Damage Recognition in GG-NER; Formation of the polybromo-BAF (pBAF) complex; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Formation of annular gap junctions; Folding of actin by CCT/TriC; Cell-extracellular matrix interactions; MAP2K and MAPK activation; RHO GTPases Activate Formins; Recycling pathway of L1; RHO GTPases activate IQGAPs; Clathrin-mediated endocytosis; Formation of the dystrophin-glycoprotein complex (DGC); EPHB-mediated forward signaling; UCH proteinases; B-WICH complex positively regulates rRNA expression; Adherens junctions interactions; Formation of the non-canonical BAF (ncBAF) complex; Formation of annular gap junctions; Formation of the polybromo-BAF (pBAF) complex; VEGFA-VEGFR2 Pathway; Cell-extracellular matrix interactions; RHO GTPases Activate WASPs and WAVEs; Regulation of CDH1 Function; Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; UCH proteinases; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); Formation of the polybromo-BAF (pBAF) complex; B-WICH complex positively regulates rRNA expression; DNA Damage Recognition in GG-NER; Formation of the canonical BAF (cBAF) complex; RHO GTPases Activate Formins; Regulation of CDH1 Function; Interaction between L1 and Ankyrins; RHOF GTPase cycle; Formation of the non-canonical BAF (ncBAF) complex; Adherens junctions interactions; Formation of the dystrophin-glycoprotein complex (DGC); VEGFA-VEGFR2 Pathway; RHO GTPases Activate WASPs and WAVEs; Cell-extracellular matrix interactions; EPHB-mediated forward signaling; MAP2K and MAPK activation; Recycling pathway of L1; RHO GTPases activate IQGAPs; Formation of annular gap junctions; B-WICH complex positively regulates rRNA expression; UCH proteinases; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); MAP2K and MAPK activation; Formation of the polybromo-BAF (pBAF) complex; RHO GTPases Activate Formins; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases Activate WASPs and WAVEs; Formation of the dystrophin-glycoprotein complex (DGC); VEGFA-VEGFR2 Pathway; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; DNA Damage Recognition in GG-NER; RHOF GTPase cycle; Cell-extracellular matrix interactions; Adherens junctions interactions; Formation of the non-canonical BAF (ncBAF) complex; Formation of the canonical BAF (cBAF) complex; RHO GTPases activate IQGAPs; Regulation of CDH1 Function; Gap junction degradation; Formation of annular gap junctions; Regulation of actin dynamics for phagocytic cup formation; RHOF GTPase cycle; Clathrin-mediated endocytosis; RHO GTPases Activate Formins; Cell-extracellular matrix interactions; VEGFA-VEGFR2 Pathway; Adherens junctions interactions; RHO GTPases activate IQGAPs; UCH proteinases; EPHB-mediated forward signaling; MAP2K and MAPK activation; RHO GTPases Activate WASPs and WAVEs; Formation of the dystrophin-glycoprotein complex (DGC); Formation of annular gap junctions; Formation of the canonical BAF (cBAF) complex; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of the non-canonical BAF (ncBAF) complex; Regulation of CDH1 Function | 0.946568086066385 | 0.963278515868644 | 4.828873920581084E7 | 6.5074451419171505E7 | 1.9003581889821532E8 | 5.335770948168167E7 | 1.0984219759318356E8 | 0.7552692448247239 | 0.14400994044310264 |
| P63260 | Actin, cytoplasmic 2 [OS=Mus musculus] | 217.791 | cell organization and biogenesis;stress response;developmental processes;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 11465 | ENSMUSG00000062825 | Actg1 | mmu:11465; P02571; P14104; P63260; P99022 | Myometrial relaxation and contraction pathways; Regulation of actin cytoskeleton; Focal adhesion | Platelet degranulation ; RHO GTPases activate IQGAPs; Adherens junctions interactions; Regulation of CDH1 Function; RHO GTPases Activate Formins; Regulation of actin dynamics for phagocytic cup formation; Interaction between L1 and Ankyrins; MAP2K and MAPK activation; Recycling pathway of L1; Clathrin-mediated endocytosis; Formation of the dystrophin-glycoprotein complex (DGC); EPHB-mediated forward signaling; RHOF GTPase cycle; Formation of annular gap junctions; VEGFA-VEGFR2 Pathway; Cell-extracellular matrix interactions; RHO GTPases Activate WASPs and WAVEs; RHOBTB2 GTPase cycle | 0.85271451854395 | 0.731487178650893 | 145698.54484736864 | 254666.434448248 | 751276.7484437827 | 126248.83655432604 | 256671.2110968777 | 0.011312666587244136 | -0.20671637589735362 |
| P33434 | 72 kDa type IV collagenase [OS=Mus musculus] | 212.03 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes | extracellular matrix;plasma membrane;other membranes;cytoskeleton;mitochondrion;nucleus;other cell component | other molecular function | 17390 | ENSMUSG00000031740 | Mmp2 | mmu:17390; P33434 | Lung fibrosis; IL-3 signaling pathway; Matrix metalloproteinases | Collagen degradation; Extra-nuclear estrogen signaling; EPH-ephrin mediated repulsion of cells; Activation of Matrix Metalloproteinases | 0.993994198406889 | 0.34519376377552 | 2.11513119484971E7 | 6.116415043649567E7 | 9.997674520202683E7 | 5.359802560613743E7 | 8.73371018908004E7 | 0.5139083514604432 | 1.3414327051154107 |
| P19096 | Fatty acid synthase [OS=Mus musculus] | 203.372 | other metabolic processes;stress response;other biological processes | plasma membrane;other membranes;cytosol;ER/Golgi;other cell component | other molecular function | 14104 | ENSMUSG00000025153 | Fasn | B1ATU8; mmu:14104; P19096; Q6PB72; Q8C4Z0; Q9EQR0 | Fatty acid biosynthesis; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-9 fatty acid synthesis; Elongation of (very) long chain fatty acids | Fatty acyl-CoA biosynthesis; Vitamin B5 (pantothenate) metabolism | 0.87421335771164 | 0.746782404466558 | 1389784.0897720233 | 2729524.669883373 | 1.0491585001659483E7 | 892753.3234074336 | 2995475.6339221266 | 0.1341353617926422 | -0.6385272655543875 |
| Cont_Q3SZ57 | Alpha-fetoprotein OS=Bos taurus OX=9913 GN=AFP PE=2 SV=1 | 202.89 | other metabolic processes;developmental processes;other biological processes | non-structural extracellular;other cell component | other molecular function | 506011 | ENSBTAG00000017131 | AFP | bta:506011; Q3SZ57 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 0.938859506774495 | 0.699570390946254 | 4.5317948160280704E7 | 3.6151020512819335E7 | 2.37647047257016E7 | 3.679174310656657E7 | 4.2915740009991035E7 | 0.2474705016386588 | -0.30070051296273864 | |
| P48678 | Prelamin-A/C [OS=Mus musculus] | 202.607 | cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes | other membranes;cytoskeleton;nucleus;other cell component | other molecular function | 16905 | ENSMUSG00000028063 | Lmna | B3RH23; B3RH24; mmu:16905; P11516; P48678; P97859; Q3TIH0; Q3TTS8; Q3U733; Q3U7I5; Q3UCA0; Q3UCJ8; Q3UCU3; Q91WF2; Q9DC21 | Adipogenesis genes; FAS pathway and stress induction of HSP regulation | 0.236076921565588 | 0.901149690306505 | 4134986.871037207 | 1.1058985470826533E7 | 3.2189609583199937E7 | 6289356.16248022 | 5.369543399964929E7 | 2.2795803719185894 | 0.6050295881452582 | |
| Q02788 | Collagen alpha-2(VI) chain [OS=Mus musculus] | 202.37 | cell adhesion;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component | other molecular function | 12834 | ENSMUSG00000020241 | Col6a2 | mmu:12834; Q02788; Q05505; Q8C972; Q8K229 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | ECM proteoglycans; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation | 0.156641881403766 | 0.0961283818482991 | 4.136492509189963E7 | 5.21291258166705E7 | 5.586648846604673E7 | 1.173163988850227E7 | 2.0595787144729633E7 | -1.3397404015276635 | -1.8180032772865453 |
| P97927 | Laminin subunit alpha-4 [OS=Mus musculus] | 199.33 | cell adhesion;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | signal transduction activity or receptor binding | 16775 | ENSMUSG00000019846 | Lama4 | mmu:16775; O88785; P70409; P97927; Q14BF2 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Formation of the dystrophin-glycoprotein complex (DGC); Laminin interactions; MET activates PTK2 signaling | 0.329011090732691 | 0.50594120050135 | 5125646.74812024 | 1.037511250312096E7 | 1.8735571837149E7 | 3065544.409694903 | 5760601.1965567535 | -0.8488356911350236 | -0.7415907489564434 |
| P20152 | Vimentin [OS=Mus musculus] | 183.446 | cell organization and biogenesis;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component | cytoskeletal activity;nucleic acid binding activity;other molecular function | 22352 | ENSMUSG00000026728 | Vim | mmu:22352; O08704; P20152; Q8CCH1 | Spinal cord injury; Primary focal segmental glomerulosclerosis (FSGS); Alpha 6 beta 4 integrin signaling pathway | Aggrephagy; Striated Muscle Contraction; Caspase-mediated cleavage of cytoskeletal proteins; RHOBTB1 GTPase cycle | 0.873609880131656 | 0.840672080806375 | 7365249.698992513 | 3.3401280645601466E7 | 8.643236711147267E7 | 1.292797841903164E7 | 7.464184195594883E7 | 1.1600811699488573 | 0.8116903529805907 |
| Q64727 | Vinculin [OS=Mus musculus] | 182.753 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | plasma membrane;other membranes;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 22330 | ENSMUSG00000021823 | Vcl | mmu:22330; Q64727; Q8BP32; Q8BS46; Q922C5; Q922D9 | Primary focal segmental glomerulosclerosis (FSGS); IL-3 signaling pathway; Regulation of actin cytoskeleton; Integrin-mediated cell adhesion; Focal adhesion | Neutrophil degranulation; High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells; Platelet degranulation ; MAP2K and MAPK activation; Smooth Muscle Contraction; Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells; Regulation of CDH1 Function | 0.964629994744883 | 0.977491813528386 | 1953982.7579073233 | 4840837.086136207 | 1.55412767194393E7 | 2359150.5810886133 | 6758257.200309387 | 0.48139471401466805 | 0.2718497696931775 |
| Q8K4G1 | Latent-transforming growth factor beta-binding protein 4 [OS=Mus musculus] | 180.216 | cell-cell signaling;cell organization and biogenesis;transport;signal transduction | non-structural extracellular;extracellular matrix | other molecular function | 108075 | ENSMUSG00000040488 | Ltbp4 | E9QPD9; mmu:108075; Q8K4G0; Q8K4G1 | TGF-beta receptor signaling activates SMADs; Molecules associated with elastic fibres | 0.775297640004946 | 0.703189639676216 | 1469976.6770863 | 2473680.681365607 | 4126124.1405319436 | 2657641.7444799202 | 7291299.088613093 | 1.5595166020390654 | 0.8543533743061732 | |
| Q68FD5 | Clathrin heavy chain 1 [OS=Mus musculus] | 180.117 | cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes | plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component | nucleic acid binding activity;other molecular function | 67300 | ENSMUSG00000047126 | Cltc | mmu:67300; Q68FD5 | IL-7 signaling pathway; Kit receptor signaling pathway | MHC class II antigen presentation; Recycling pathway of L1; Cargo recognition for clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis; LDL clearance; Retrograde neurotrophin signalling; Formation of annular gap junctions; Lysosome Vesicle Biogenesis; WNT5A-dependent internalization of FZD4; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation; RHOU GTPase cycle; RHOV GTPase cycle | 0.688274955487563 | 0.946476383814868 | 1426606.2225329466 | 2101059.0869428 | 7198111.7488871245 | 2078296.563295177 | 6830362.818457293 | 1.7008454796013681 | 0.5428143634365035 |
| P02469 | Laminin subunit beta-1 [OS=Mus musculus] | 179.863 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;nucleus;other cell component | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 16777 | ENSMUSG00000002900 | Lamb1 | E9PXZ9; P02469 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Inflammatory response pathway; Alpha 6 beta 4 integrin signaling pathway; Focal adhesion | 0.269583968882479 | 0.356773085915651 | 1.4326337702720901E7 | 1.8407714250900764E7 | 2.406357201653607E7 | 2.1078383512013834E7 | 1.149610392953332E7 | -0.6791654838846833 | 0.5570943768396376 | |
| Q01853 | Transitional endoplasmic reticulum ATPase [OS=Mus musculus] | 179.055 | cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;other biological processes | other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;enzyme regulator activity;other molecular function | 269523 | ENSMUSG00000028452 | Vcp | mmu:269523; Q01853; Q3TFH9; Q3TIM2; Q3TXN9; Q6PI18; Q8BSR6; Q8CEG4 | IL-9 signaling pathway | RHOH GTPase cycle; Neutrophil degranulation; Protein methylation; Ovarian tumor domain proteases; Neddylation; ABC-family proteins mediated transport; Translesion Synthesis by POLH; Hedgehog ligand biogenesis; KEAP1-NFE2L2 pathway; HSF1 activation; N-glycan trimming in the ER and Calnexin/Calreticulin cycle; Josephin domain DUBs | 0.953038161729767 | 0.901149690306505 | 5338414.413398174 | 9329554.935730066 | 2.5532499977727503E7 | 4463650.11042755 | 1.2770955118061693E7 | 0.45298626139298054 | -0.2581873602655405 |
| Q03350 | Thrombospondin-2 [OS=Mus musculus] | 178.303 | cell adhesion;other biological processes | non-structural extracellular;extracellular matrix;other cell component | other molecular function | 21826 | ENSMUSG00000023885 | Thbs2 | mmu:21826; Q03350; Q8CG21 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Signaling by PDGF; O-glycosylation of TSR domain-containing proteins | 0.792896707923278 | 0.620448351319483 | 7439397.130180354 | 1.1102887711296873E7 | 1.7857870851453733E7 | 4211942.301314384 | 1.05864549049655E7 | -0.06871539719065865 | -0.820700040470399 |
| Q80YX1 | Tenascin [OS=Mus musculus] | 175.9 | cell adhesion;cell-cell signaling;cell organization and biogenesis;stress response;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | signal transduction activity or receptor binding;other molecular function | 21923 | ENSMUSG00000028364 | Tnc | mmu:21923; Q64706; Q80YX1; Q80YX2 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Integrin cell surface interactions; ECM proteoglycans; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 1.08858887903907E-8 | 0.00972980877962454 | 1449614.4281484466 | 1.2106484504902953E7 | 3597849.650032737 | 96243.5238250637 | 211010.04547923067 | -5.842324501720179 | -3.9128359438342706 |
| Q61147 | Ceruloplasmin [OS=Mus musculus] | 175.43 | cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular | other molecular function | 12870 | ENSMUSG00000003617 | Cp | mmu:12870; Q61147; Q6P5C8 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Iron uptake and transport; Metal ion SLC transporters | 0.114472406028442 | 0.217345018530886 | 4703216.257241024 | 9598922.193485493 | 1.8258425380319133E7 | 1756646.5467629798 | 3587720.1567995367 | -1.4198050591681202 | -1.4208237326658222 | |
| Q3UQ28 | Peroxidasin homolog [OS=Mus musculus] | 173.636 | cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes | extracellular matrix;ER/Golgi;other cell component | extracellular structural activity;other molecular function | 69675 | ENSMUSG00000020674 | Pxdn | A4FU83; E9QNQ9; mmu:69675; Q3UQ28 | Crosslinking of collagen fibrils | 0.414844709855988 | 0.622521206052951 | 3468268.863888983 | 1.0141728842991263E7 | 7424302.20024892 | 1748064.7562207088 | 5865453.59009746 | -0.789989022164196 | -0.988457112373562 | |
| Q61316 | Heat shock 70 kDa protein 4 [OS=Mus musculus] | 169.044 | protein metabolism;other metabolic processes | other cell component | other molecular function | Hspa4 | Q61316 | Regulation of HSF1-mediated heat shock response | 0.937908804051419 | 0.905946265571965 | 1715523.4149199834 | 3885769.0116153997 | 1.2475039717842167E7 | 1450318.0074060035 | 4790126.20554149 | 0.3018635242804291 | -0.2422795462920771 | |||
| Cont_P02533 | Keratin, type I cytoskeletal 14 OS=Homo sapiens OX=9606 GN=KRT14 PE=1 SV=4 | 164.831 | cell organization and biogenesis;other biological processes | plasma membrane;cytosol;cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 3861 | ENSG00000186847 | KRT14 | hsa:3861; P02533; Q14715; Q53XY3; Q9BUE3; Q9UBN2; Q9UBN3; Q9UCY4 | Corticotropin-releasing hormone signaling | Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin; Developmental Lineage of Mammary Gland Myoepithelial Cells; Type I hemidesmosome assembly | 0.735573385767802 | 0.645534074006669 | 1.0299655985485494E7 | 9892865.41378706 | 7326107.9926405 | 2.9333304518974166E7 | 9460012.597296894 | -0.06454634544610054 | 1.5099434544998684 |
| P11499 | Heat shock protein HSP 90-beta [OS=Mus musculus] | 164.719 | cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component | enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function | 15516 | ENSMUSG00000023944 | Hsp90ab1 | mmu:15516; O89078; P11499; Q3UIQ7 | Focal adhesion: PI3K-Akt-mTOR signaling pathway | Neutrophil degranulation; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of actin dynamics for phagocytic cup formation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Attenuation phase; Estrogen-dependent gene expression; Sema3A PAK dependent Axon repulsion; Aryl hydrocarbon receptor signalling; DDX58/IFIH1-mediated induction of interferon-alpha/beta; HSF1 activation; RHOBTB2 GTPase cycle; The NLRP3 inflammasome | 0.952333191127893 | 0.975071223710592 | 1.0807613687705928E7 | 3.193268303009924E7 | 8.29576662608192E7 | 1.1608041082716169E7 | 4.22825068683512E7 | 0.4050271392280359 | 0.10307651810960865 |
| Q9JKF1 | Ras GTPase-activating-like protein IQGAP1 [OS=Mus musculus] | 163.926 | cell organization and biogenesis;developmental processes;signal transduction;other biological processes | plasma membrane;other membranes;cytoskeleton;nucleus;other cell component | enzyme regulator activity;other molecular function | 29875 | ENSMUSG00000030536 | Iqgap1 | G3UW45; mmu:29875; Q9JKF1 | G13 signaling pathway; Regulation of actin cytoskeleton | RHO GTPases activate IQGAPs; Neutrophil degranulation; RAC1 GTPase cycle; RAC2 GTPase cycle; RHOA GTPase cycle; MAP2K and MAPK activation; RHOQ GTPase cycle; RHOC GTPase cycle; RHOU GTPase cycle; RHOV GTPase cycle; Nephrin family interactions | 0.830676695521175 | 0.777195460870953 | 331165.4406654323 | 1068898.0084058929 | 3041433.200354057 | 944145.2185002686 | 3795509.9873349466 | 1.8281695465197003 | 1.5114566510612586 |
| P52480 | Pyruvate kinase PKM [OS=Mus musculus] | 163.393 | cell organization and biogenesis;other metabolic processes;other biological processes | cytosol;ER/Golgi;nucleus;other cell component | nucleic acid binding activity;kinase activity;other molecular function | 18746 | ENSMUSG00000032294 | Pkm | mmu:18746; P52480; Q3TBV8; Q3TBW5; Q3TC59; Q3U1X3; Q3U5P6; Q4VC20; Q64484; Q91YI8; Q9CWB1 | Glycolysis and gluconeogenesis; Purine metabolism | Neutrophil degranulation; Pyruvate metabolism; Glycolysis; Regulation of pyruvate metabolism | 0.938859506774495 | 0.958705855138011 | 1.1706302394897154E7 | 1.6687028973496003E7 | 3.53200761892009E7 | 1.3595916090065738E7 | 3.1698865102110166E7 | 0.9257040749614063 | 0.215887911460558 |
| P63017 | Heat shock cognate 71 kDa protein [OS=Mus musculus] | 161.557 | cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component | signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function | 15481 | ENSMUSG00000015656 | Hspa8 | mmu:15481; P08109; P12225; P63017; Q3U6R0; Q3U764; Q3U7D7; Q3U7E2; Q3U9B4; Q3U9G0; Q3UGM0; Q5FWJ6; Q62373; Q62374; Q62375; Q6NZD0 | Mapk signaling pathway; Exercise-induced circadian regulation | Neutrophil degranulation; mRNA Splicing - Major Pathway; Regulation of HSF1-mediated heat shock response; PKR-mediated signaling; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis; Attenuation phase; Lysosome Vesicle Biogenesis; GABA synthesis, release, reuptake and degradation; AUF1 (hnRNP D0) binds and destabilizes mRNA; Protein methylation | 0.987939278265184 | 0.709593139419252 | 1.5723480869725833E7 | 2.2348098618015703E7 | 7.359719450565854E7 | 1.2001189016638666E7 | 3.440867978172333E7 | 0.6226204469568586 | -0.38974328950384013 |
| Q9JHU4 | Cytoplasmic dynein 1 heavy chain 1 [OS=Mus musculus] | 161.009 | cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes | cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 13424 | ENSMUSG00000018707 | Dync1h1 | E9QM71; mmu:13424; Q9JHU4 | MHC class II antigen presentation; Neutrophil degranulation; Separation of Sister Chromatids; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; COPI-mediated anterograde transport; Recruitment of NuMA to mitotic centrosomes; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-independent Golgi-to-ER retrograde traffic; Aggrephagy; Anchoring of the basal body to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; AURKA Activation by TPX2 | 0.771389136401717 | 0.695927216301667 | 451351.8596347517 | 1275535.4534856554 | 3370818.0273642703 | 1462326.6297541 | 5162177.518126 | 2.0168767548265785 | 1.695941135437884 | |
| Q99K41 | EMILIN-1 [OS=Mus musculus] | 157.011 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 100952 | ENSMUSG00000029163 | Emilin1 | mmu:100952; Q99K41 | Molecules associated with elastic fibres | 0.169879542413978 | 0.0921665663508908 | 1671715.86234765 | 5498413.09956387 | 5014687.354848887 | 384416.66366236034 | 2364922.89508055 | -1.2172221542664499 | -2.120586876331411 | |
| Q61879 | Myosin-10 [OS=Mus musculus] | 146 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;nucleic acid binding activity;other molecular function | 77579 | ENSMUSG00000020900 | Myh10 | mmu:77579; Q5SV63; Q61879 | Regulation of actin cytoskeleton | RHO GTPases activate PAKs | 0.996007724449986 | 0.953146340313072 | 266023.60455562966 | 458865.269073755 | 1364536.1643212799 | 562909.3462758837 | 1089526.38375758 | 1.2475586126477243 | 1.0813483389566705 |
| Cont_P00761 | Trypsin OS=Sus scrofa OX=9823 PE=1 SV=1 | 143.502 | protein metabolism;other biological processes | non-structural extracellular | other molecular function | 0.822223648478518 | 0.960577895552113 | 3.334729419178533E9 | 2.1792138371661735E9 | 1.3557622678922963E9 | 4.479417756781787E9 | 2.35988129070601E9 | 0.11490652036236093 | 0.42574151472675936 | ||||||
| P20029 | Endoplasmic reticulum chaperone BiP [OS=Mus musculus] | 142.966 | protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component | enzyme regulator activity;translation activity;other molecular function | 14828 | ENSMUSG00000026864 | Hspa5 | mmu:14828; O35642; P20029; Q3UFF2; Q61630 | Mapk signaling pathway | Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Regulation of HSF1-mediated heat shock response | 0.916283277860523 | 0.985707795620743 | 7392689.481756757 | 8222965.927916382 | 1.797212351620547E7 | 8403011.594768586 | 1.57890948929286E7 | 0.9411977151669085 | 0.1848071583319896 |
| Cont_P13647 | Keratin, type II cytoskeletal 5 OS=Homo sapiens OX=9606 GN=KRT5 PE=1 SV=3 | 142.395 | cell organization and biogenesis;other biological processes | cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;cytoskeletal activity;other molecular function | 3852 | ENSG00000186081 | KRT5 | hsa:3852; P13647; Q6PI71; Q6UBJ0; Q8TA91 | Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin; Developmental Lineage of Mammary Stem Cells; Developmental Lineage of Mammary Gland Myoepithelial Cells; Type I hemidesmosome assembly | 0.873755746039336 | 0.2733017775894 | 7868513.182470503 | 9974982.226041706 | 1.0805570452735417E7 | 2.8752414910160065E7 | 1.3998817771053001E7 | 0.4889188179733309 | 1.8695201748341668 | |
| Cont_P08779 | Keratin, type I cytoskeletal 16 OS=Homo sapiens OX=9606 GN=KRT16 PE=1 SV=4 | 140.751 | cell organization and biogenesis;stress response;other biological processes | plasma membrane;cytosol;cytoskeleton | cytoskeletal activity | 3868 | ENSG00000186832 | KRT16 | A8K488; hsa:3868; P08779; P30654; Q16402; Q9UBG8 | Vitamin D receptor pathway | Formation of the cornified envelope | 0.82543231800733 | 0.895302208460818 | 3908256.3409277797 | 2249474.51763106 | 2096552.2825116366 | 5401589.786976026 | 2569640.8216647534 | 0.19197869304636359 | 0.46685898520849145 |
| Cont_P02465 | Collagen alpha-2(I) chain OS=Bos taurus OX=9913 GN=COL1A2 PE=1 SV=2 | 139.99 | non-structural extracellular;extracellular matrix | extracellular structural activity;other molecular function | 282188 | ENSBTAG00000013472 | COL1A2 | A6QP13; bta:282188; O62649; P02465 | Inflammatory response pathway; Focal adhesion | Fibronectin matrix formation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Collagen degradation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; Collagen chain trimerization; GPVI-mediated activation cascade; Platelet Aggregation (Plug Formation); Platelet Adhesion to exposed collagen; GP1b-IX-V activation signalling | 0.731850662833984 | 0.549852418071669 | 85775.39066064726 | 163731.944383145 | 196860.296999494 | 48702.045776696206 | 54970.44581499727 | -1.57460773663475 | -0.8165814161100421 | |
| Cont_P12763 | Alpha-2-HS-glycoprotein OS=Bos taurus OX=9913 GN=AHSG PE=1 SV=2 | 132.772 | stress response;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component | enzyme regulator activity | 280988 | AHSG | A6QLF7; bta:280988; P12763 | Neutrophil degranulation; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 0.946568086066385 | 0.335956814949331 | 8.712402787486216E8 | 6.41500953397899E8 | 4.2252677685996836E8 | 4.440672611032756E8 | 7.064361313920757E8 | 0.13910772352571524 | -0.9722924411478902 | ||
| P07901 | Heat shock protein HSP 90-alpha [OS=Mus musculus] | 132.382 | cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component | signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function | 15519 | ENSMUSG00000021270 | Hsp90aa1 | mmu:15519; P07901 | EBV LMP1 signaling; Focal adhesion: PI3K-Akt-mTOR signaling pathway; IL-6 signaling pathway; IL-2 signaling pathway | Regulation of necroptotic cell death; Recruitment of NuMA to mitotic centrosomes; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of actin dynamics for phagocytic cup formation; Neutrophil degranulation; Downregulation of ERBB2 signaling; Anchoring of the basal body to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; AURKA Activation by TPX2; Extra-nuclear estrogen signaling; Attenuation phase; Estrogen-dependent gene expression; Sema3A PAK dependent Axon repulsion; VEGFR2 mediated vascular permeability; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation; DDX58/IFIH1-mediated induction of interferon-alpha/beta; eNOS activation; HSF1 activation; RHOBTB2 GTPase cycle; Drug-mediated inhibition of ERBB2 signaling | 0.974827674952665 | 0.968364585136618 | 1667357.9717776468 | 3968795.71909318 | 1.1896107480962433E7 | 1606774.576019598 | 6014683.841021903 | 0.5997875986262169 | -0.0533963366441969 |
| Q02819 | Nucleobindin-1 [OS=Mus musculus] | 131.152 | signal transduction | non-structural extracellular;other membranes;ER/Golgi | enzyme regulator activity;nucleic acid binding activity;other molecular function | 18220 | ENSMUSG00000030824 | Nucb1 | mmu:18220; Q02819; Q3TU42; Q9CWA1; Q9D8J4; Q9DBL3 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 0.0679830640731695 | 0.397987186613988 | 5493436.34719679 | 1.9240052036173E7 | 2.4992726743775133E7 | 2379424.5332984333 | 6548209.148806977 | -1.5549403938694841 | -1.2070961924278651 | |
| Q91V92 | ATP-citrate synthase [OS=Mus musculus] | 129.973 | other metabolic processes | cytosol | other molecular function | 104112 | ENSMUSG00000020917 | Acly | mmu:104112; Q91V92 | Fatty acid biosynthesis | Neutrophil degranulation; Fatty acyl-CoA biosynthesis | 0.626059420687734 | 0.643183834410259 | 1276919.6113413726 | 2339759.4103227933 | 7993361.0560920695 | 644183.8162072281 | 1777761.9344937534 | -0.39629804848056854 | -0.9871233812801825 |
| A2ASQ1 | Agrin [OS=Mus musculus] | 128.989 | cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cell component | signal transduction activity or receptor binding;other molecular function | 11603 | ENSMUSG00000041936 | Agrn | A2ASP9; A2ASQ0; A2ASQ1; B2RWU1 | Primary focal segmental glomerulosclerosis (FSGS) | ECM proteoglycans; Retinoid metabolism and transport; Glycosaminoglycan-protein linkage region biosynthesis; HS-GAG biosynthesis; HS-GAG degradation; Formation of the dystrophin-glycoprotein complex (DGC) | 0.460727828548759 | 0.686318824668434 | 1695001.2322350666 | 3018900.06344302 | 4324221.40670855 | 1028829.4241236168 | 2045725.4701757336 | -0.561410446190177 | -0.72028251328634 |
| Q61508 | Extracellular matrix protein 1 [OS=Mus musculus] | 127.379 | stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular | signal transduction activity or receptor binding;other molecular function | 13601 | ENSMUSG00000028108 | Ecm1 | mmu:13601; Q3U5Q5; Q61508 | Platelet degranulation | 2.27890527565265E-4 | 1.51989274634622E-7 | 5.132626536679041E7 | 6.196550035866306E7 | 5.7086940781247534E7 | 3515293.344106073 | 1.1331897286900917E7 | -2.4510757802272813 | -3.8679803006942106 | |
| Cont_P04259 | Keratin, type II cytoskeletal 6B OS=Homo sapiens OX=9606 GN=KRT6B PE=1 SV=5 | 126.901 | cell organization and biogenesis;other biological processes | cytosol;cytoskeleton | bone, tooth or skin structural activity;cytoskeletal activity | 3854 | ENSG00000185479 | KRT6B | hsa:3854; P04259; P48669 | Formation of the cornified envelope | 0.854305439376382 | 0.937453377971347 | 1156058.5455969477 | 510017.07482617133 | 452820.542152991 | 1115770.6869766254 | 854901.7358096777 | 0.7452130553684702 | -0.05117390608584228 | |
| P17182 | Alpha-enolase [OS=Mus musculus] | 126.804 | other metabolic processes;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;other cell component | nucleic acid binding activity;other molecular function | 13806; 433182 | ENSMUSG00000059040; ENSMUSG00000063524 | Eno1 | mmu:13806; mmu:433182; P17182; Q99KT7; Q9DCY7 | Glycolysis and gluconeogenesis | 0.720832939248489 | 0.858218537342417 | 9473047.660860082 | 1.1146559483992001E7 | 2.0899983974591535E7 | 1.3905788568310633E7 | 2.89416009584274E7 | 1.3765462552828784 | 0.5537850111265004 | |
| P08113 | Endoplasmin [OS=Mus musculus] | 126.346 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cell component | signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function | 22027 | ENSMUSG00000020048 | Hsp90b1 | mmu:22027; P08113; P11427 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Hypoxia-dependent self-renewal of myoblasts | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Scavenging by Class A Receptors; Trafficking and processing of endosomal TLR; Interleukin-4 and Interleukin-13 signaling | 0.854305439376382 | 0.866766165039268 | 4030450.84914005 | 5006439.15200075 | 1.2828763316623202E7 | 6037105.20140975 | 1.2434595462188734E7 | 1.3125028215609296 | 0.5829157128019473 |
| P58252 | Elongation factor 2 [OS=Mus musculus] | 126.048 | cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;translational apparatus;other cell component | cytoskeletal activity;translation activity;nucleic acid binding activity;other molecular function | 13629 | ENSMUSG00000034994 | Eef2 | mmu:13629; P58252; Q544E4 | Translation factors | Neutrophil degranulation; Protein methylation; Peptide chain elongation; Synthesis of diphthamide-EEF2 | 0.922179983282929 | 0.866546043492515 | 6414138.274151959 | 1.0566307796994643E7 | 2.9620591728864197E7 | 4859646.5618234025 | 1.3065706600835832E7 | 0.3063138071523588 | -0.4004040637211755 |
| Cont_P02538 | Keratin, type II cytoskeletal 6A OS=Homo sapiens OX=9606 GN=KRT6A PE=1 SV=3 | 123.757 | cell organization and biogenesis;stress response;other biological processes | cytosol;cytoskeleton | bone, tooth or skin structural activity;cytoskeletal activity | 3853 | ENSG00000205420 | KRT6A | A4QPC1; hsa:3853; P02538; P48667; Q08AR4; Q6NT67; Q96CL4 | Ectoderm differentiation; Ectoderm differentiation; Pancreatic cancer subtypes | Formation of the cornified envelope | 0.792564971776066 | 0.709593139419252 | 4785085.111074816 | 3779160.7730984767 | 3044210.664784646 | 8485501.699692694 | 3982846.61307857 | 0.07573402481836149 | 0.826455374898488 |
| P97298 | Pigment epithelium-derived factor [OS=Mus musculus] | 123.502 | cell cycle OR cell proliferation;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | enzyme regulator activity | 20317 | ENSMUSG00000000753 | Serpinf1 | mmu:20317; O70629; O88691; P97298 | 0.00901230529014985 | 0.300753028734261 | 1.46490289953418E7 | 7.121805491857927E7 | 6.883649650666605E7 | 5921015.69252881 | 1.5757205380580032E7 | -2.1762313456020066 | -1.3068884569216235 | ||
| Q70E20 | Sushi, nidogen and EGF-like domain-containing protein 1 [OS=Mus musculus] | 122.942 | cell adhesion | non-structural extracellular;extracellular matrix | other molecular function | 208777 | Sned1 | A6H6I3; mmu:208777; Q70E20; Q810H2; Q8BMD9 | 0.889058672589993 | 0.817293288705596 | 3293936.3484006864 | 6267209.5561869135 | 8981713.661313256 | 4995161.517920501 | 1.4223395042125002E7 | 1.1823707306994269 | 0.6007186512533814 | |||
| P13020 | Gelsolin [OS=Mus musculus] | 122.934 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 227753 | ENSMUSG00000026879 | Gsn | mmu:227753; P13020; Q3UPB1; Q8R590 | Regulation of actin cytoskeleton | Neutrophil degranulation; Caspase-mediated cleavage of cytoskeletal proteins | 0.65414435708462 | 0.709593139419252 | 6438031.44422588 | 9825643.045518672 | 2.1865108079878632E7 | 1.1033925013460701E7 | 2.9144067496602204E7 | 1.5685785077495134 | 0.7772545527981521 |
| Q61398 | Procollagen C-endopeptidase enhancer 1 [OS=Mus musculus] | 120.4 | protein metabolism;other biological processes | enzyme regulator activity;other molecular function | 18542 | ENSMUSG00000029718 | Pcolce | mmu:18542; O35113; Q61398 | mRNA processing | Collagen biosynthesis and modifying enzymes; Crosslinking of collagen fibrils | 0.133905327763598 | 0.0895861566882082 | 2.52047208020085E7 | 2.958750643636163E7 | 3.717663177971887E7 | 7672570.19904635 | 1.2538308810459368E7 | -1.2386453468264698 | -1.7159121278098002 | |
| P26039 | Talin-1 [OS=Mus musculus] | 118.226 | cell adhesion;cell organization and biogenesis;signal transduction | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;other molecular function | 21894 | ENSMUSG00000028465 | Tln1 | A2AIM8; mmu:21894; P26039; Q8VEF0 | Primary focal segmental glomerulosclerosis (FSGS); Integrin-mediated cell adhesion; Focal adhesion | Platelet degranulation ; MAP2K and MAPK activation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; Smooth Muscle Contraction; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 0.850917681937748 | 0.87222702623065 | 165904.24421521465 | 567933.664164035 | 2047443.5453512298 | 286851.2614141297 | 2291518.0404973766 | 2.0125093088074704 | 0.7899520679334946 |
| Q8BPB5 | EGF-containing fibulin-like extracellular matrix protein 1 [OS=Mus musculus] | 117.738 | protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes | extracellular matrix | signal transduction activity or receptor binding;kinase activity;other molecular function | 216616 | ENSMUSG00000020467 | Efemp1 | mmu:216616; Q6Y3N6; Q8BPB5 | 0.278244203695445 | 0.145805028390539 | 4441372.613318663 | 7007290.288389671 | 9374363.446007233 | 1370373.3251651835 | 3606517.1409647237 | -0.9582503828225413 | -1.6964366384968077 | ||
| P09411 | Phosphoglycerate kinase 1 [OS=Mus musculus] | 116.462 | protein metabolism;other metabolic processes;stress response;other biological processes | non-structural extracellular;other membranes;cytosol;mitochondrion;other cell component | kinase activity;other molecular function | 18655 | ENSMUSG00000062070 | Pgk1 | mmu:18655; P09411; Q3TPE6; Q3UKV8; Q5XJE7 | Glycolysis and gluconeogenesis | Gluconeogenesis; Glycolysis | 0.465126095372736 | 0.820281310709571 | 3210948.6178334034 | 3594147.655304653 | 7046094.17133664 | 4500077.619792943 | 1.4795712145397767E7 | 2.041457553634679 | 0.48695030706009684 |
| P27773 | Protein disulfide-isomerase A3 [OS=Mus musculus] | 115.891 | cell adhesion;cell organization and biogenesis;stress response;signal transduction;other biological processes | non-structural extracellular;other membranes;ER/Golgi;other cell component | nucleic acid binding activity;other molecular function | 14827 | ENSMUSG00000027248 | Pdia3 | mmu:14827; P27773; Q3TEI9; Q3TIL2; Q3UZK8; Q8C2F4; Q99LF6 | ER-Phagosome pathway; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Calnexin/calreticulin cycle | 0.850917681937748 | 0.881496352314601 | 5161827.016313557 | 6480316.532156386 | 1.845644105269933E7 | 7238345.98431998 | 1.5315044241817234E7 | 1.2408133459469528 | 0.48777827396885565 | |
| P10107 | Annexin A1 [OS=Mus musculus] | 115.566 | cell organization and biogenesis;stress response;transport;signal transduction;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component | enzyme regulator activity;other molecular function | 16952 | ENSMUSG00000024659 | Anxa1 | mmu:16952; P10107 | Spinal cord injury; Prostaglandin synthesis and regulation | G alpha (q) signalling events; G alpha (i) signalling events; Formyl peptide receptors bind formyl peptides and many other ligands | 0.954328834404239 | 0.529099828181544 | 1675870.316312303 | 6017153.19339518 | 1.1246783571413433E7 | 4211649.667813237 | 1.08370832078509E7 | 0.8488235161720351 | 1.3294749220803617 |
| Cont_Q2KJF1 | Alpha-1B-glycoprotein OS=Bos taurus OX=9913 GN=A1BG PE=1 SV=1 | 115.502 | signal transduction | non-structural extracellular;plasma membrane;other membranes | 518955 | A1BG | bta:518955; Q2KJF1 | Platelet degranulation ; Neutrophil degranulation | 0.932231143665149 | 0.601376052147163 | 9820849.23751892 | 8859077.038578315 | 5863583.3120338395 | 6762503.63408608 | 1.0317459698123023E7 | 0.21985949488281362 | -0.5382903197621131 | |||
| Cont_Q3MHN5 | Vitamin D-binding protein OS=Bos taurus OX=9913 GN=GC PE=2 SV=1 | 113.599 | other metabolic processes;transport | non-structural extracellular;other cell component | transporter activity;cytoskeletal activity;other molecular function | 530076 | GC | bta:530076; Q3MHN5 | 0.946173787415917 | 0.570795727084329 | 1.5974245944817802E7 | 1.026921939097026E7 | 8132938.425379939 | 1.0785165311962552E7 | 1.4618596373270534E7 | 0.5094782752262966 | -0.5666995412925446 | |||
| P17742 | Peptidyl-prolyl cis-trans isomerase A [OS=Mus musculus] | 113.527 | cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes | non-structural extracellular;cytosol;nucleus;other cell component | signal transduction activity or receptor binding;other molecular function | 268373 | ENSMUSG00000071866 | Ppia | mmu:268373; P17742; Q9CWJ5; Q9R137 | Neutrophil degranulation; Basigin interactions | 0.946239447314336 | 0.937453377971347 | 1.0145464905716315E7 | 3.610988970082183E7 | 6.97111893668837E7 | 1.0696784170781441E7 | 4.607074026803666E7 | 0.3514567659376412 | 0.07634216032534753 | |
| Q69ZN7 | Myoferlin [OS=Mus musculus] | 112.647 | cell organization and biogenesis;other metabolic processes;stress response;other biological processes | plasma membrane;other membranes;nucleus | other molecular function | 226101 | ENSMUSG00000048612 | Myof | mmu:226101; Q69ZN7; Q7TMG0; Q80V33; Q8BU64; Q8BU70; Q8BUC1; Q8BVY6; Q8C0D1; Q8R3B4 | 0.816275429153737 | 0.609903091678244 | 322363.41862436634 | 911704.7850761963 | 2642353.10757036 | 1104935.9693987637 | 3065805.015040973 | 1.7496272919339693 | 1.7772028252973333 | ||
| P26041 | Moesin [OS=Mus musculus] | 112.068 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function | 17698 | ENSMUSG00000031207 | Msn | B1AX70; mmu:17698; P26041; Q3UL28; Q8BSN4 | Regulation of actin cytoskeleton | Recycling pathway of L1 | 0.910750689050232 | 0.97925982662951 | 9136364.2843242 | 1.7052591672350097E7 | 3.507274229077233E7 | 1.120013397828275E7 | 1.9030746620886367E7 | 0.15834114468472432 | 0.29382391022615884 |
| P05064 | Fructose-bisphosphate aldolase A [OS=Mus musculus] | 112.015 | cell organization and biogenesis;other metabolic processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | other molecular function | 11674 | ENSMUSG00000030695 | Aldoa | mmu:11674; P05064 | Glycolysis and gluconeogenesis | Platelet degranulation ; Neutrophil degranulation; Gluconeogenesis; Glycolysis | 0.907383519445145 | 0.988377544628277 | 4319055.57861477 | 4893427.94836492 | 1.3571821307477335E7 | 4518789.603964283 | 1.0653934694757948E7 | 1.1224689803597754 | 0.0652205047103212 |
| B2RQC6 | Multifunctional protein CAD [OS=Mus musculus] | 111.853 | other metabolic processes;stress response;transport;developmental processes;other biological processes | cytosol;nucleus;other cell component | kinase activity;other molecular function | 69719 | ENSMUSG00000013629 | Cad | B2RQC6; B7ZN27; mmu:69719 | Mechanisms associated with pluripotency | Pyrimidine biosynthesis | 0.340675523776301 | 0.798180783050573 | 448793.6641228067 | 957747.5456383955 | 3728337.7638301034 | 139659.55402474166 | 452794.3373622177 | -1.0807895075821645 | -1.6841380378584145 |
| Q8BND5 | Sulfhydryl oxidase 1 [OS=Mus musculus] | 111.186 | cell organization and biogenesis;other biological processes | non-structural extracellular;other membranes;ER/Golgi | other molecular function | 104009 | ENSMUSG00000033684 | Qsox1 | mmu:104009; Q3TDY9; Q3TE19; Q3TR29; Q3UEL4; Q8BND5; Q8K041; Q9DBL6 | Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Neutrophil degranulation | 0.203109767081086 | 0.331332346840573 | 3849451.1157268733 | 1.052758137572049E7 | 1.39599253643295E7 | 1818282.5759143168 | 5040172.36278756 | -1.0626290505699043 | -1.082076326435299 |
