Defining the role of fibroblasts in skin expansion_Raw data of MS-Proteomics on fibroblast secretome

Selected Cell

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All identified Proteins Applied filters Filtered proteins Normalized avg abundances only_avg_abundances t-test_CM-LQ_vs_FM t-test_CM-SQ_vs_NC t-test CM-SQ_vs_CM-LQ

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Q61112	45 kDa calcium-binding protein [OS=Mus musculus]	30.66	25	8	79	8	361	42	developmental processes;other biological processes	ER/Golgi;other cytoplasmic organelle	other molecular function	20318	ENSMUSG00000029076	Sdf4	mmu:20318; Q3TK84; Q3TQP8; Q61112; Q61113			1.65082956259427E-17	0.0205397826762147	0.14694465311088	0.208161359786647	0.85271451854395	0.626053345937554	0.356773085915651	0.910753558746772			28394.3132899595	1093680.37209003	1117932.5994766	1391695.83268244	1465408.62555224	1045035.66700795	1599962.4714398	1477984.67570961	1422181.48766774	924483.941405908	415665.118333641	143223.597039285	635468.193755418
P97873	Lysyl oxidase homolog 1 [OS=Mus musculus]	53.898	25	11	127	11	607	66.5		non-structural extracellular;extracellular matrix	other molecular function	16949		Loxl1	mmu:16949; P97873; Q91ZY4; Q99KX3		Elastic fibre formation; Crosslinking of collagen fibrils	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.581276069232166	0.873724635677485	0.0838531598742529	0.822877979404198				1825350.9451255	2336200.839271	1632953.32750338	1249320.00880031	1327610.13395424	1437915.45599875	1559644.32172759	1401433.75471603	1034451.00355052	402151.87647519	73214.90659719	410835.606804482
Q9DBG9	Tax1-binding protein 3 [OS=Mus musculus]	10.622	25	2	16	2	124	13.7	signal transduction;other biological processes	plasma membrane;other membranes;cytoskeleton;nucleus;other cell component	other molecular function	76281	ENSMUSG00000040158	Tax1bp3	mmu:76281; Q9DBG9	Wnt signaling pathway	RHO GTPases Activate Rhotekin and Rhophilins	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.956980150252533	0.570352522056082	0.958705855138011	0.453674861497639				103883.495508675	82702.9032252159	136749.47809862	33411.1350601942	29718.402266846	60824.658138079	234798.376666297	152293.630034569	180530.97539541	38910.7110295417		42623.1445554526
Cont_Q03247	Apolipoprotein E OS=Bos taurus OX=9913 GN=APOE PE=1 SV=1	23.267	25	7	59	7	316	36	cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes	non-structural extracellular;extracellular matrix;other cytoplasmic organelle	signal transduction activity or receptor binding;transporter activity;enzyme regulator activity;other molecular function	281004		APOE	bta:281004; Q03247; Q3T006; Q5E967			0.871967942241348	0.916949047389333	0.7521692664391	0.872113329447229	0.826546053795161	0.787830791029295	0.970533087011962	0.0409172667845306	372050.224655792	205874.265930264	209607.231394727	820378.791852046	982804.732532525	695563.044130785	408677.338833904	422549.997072422	450579.080747438	590391.390531002	437186.208463307	257413.368402725	450353.173193421	275333.260535164	561102.91749308
P56399	Ubiquitin carboxyl-terminal hydrolase 5 [OS=Mus musculus]	73.83	25	17	111	17	858	95.8	protein metabolism;other metabolic processes;other biological processes	other cell component	other molecular function	22225	ENSMUSG00000038429	Usp5	mmu:22225; P56399		Ub-specific processing proteases; Synthesis of active ubiquitin: roles of E1 and E2 enzymes	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.873755746039336	0.983440558239231	0.968364585136618	0.548974722231314				714880.610961879	747648.646133938	400925.819916535	204275.935255948	553713.854337332	460504.985241448	2027148.54586713	2415727.36280643	1228426.49161376	336708.997096119	91781.4536020023	650612.245313823
O70493	Sorting nexin-12 [OS=Mus musculus]	10.561	25	4	28	3	165	19.1	transport	other membranes	other molecular function	55988		Snx12	mmu:55988; O70493; Q9D0N3	Nephrotic syndrome		1.65082956259427E-17		1.50457038391225E-17	1.70336894001643E-17	0.944154202827561	5.07936507936508E-17	5.0092807424594E-17	0.41759740287423				42328.0669292615	83314.189963279	81705.0870887814				232960.982004344	184799.037391829	185483.603642518		10363.9546718789	23984.6655285301
Cont_Q1RMN8	Immunoglobulin light chain, lambda gene cluster OS=Bos taurus OX=9913 GN=IGL PE=2 SV=1	26.96	25	4	64	4	234	24.5						IGL@	Q1RMN8			0.728270455161889	0.837102496454904	0.691595421078038	0.643510937293172	0.854305439376382	0.525633405661817	0.737704292740107	0.380888676065133	441839.47131325	442047.249073637	136316.51191211	519808.256987152	467488.138293798	633553.713411221	705946.426859161	507580.263966	415618.750290634	785166.64305973	508408.515538668	348626.725513859	130930.823941882	220582.802137347	548861.844628794
P54728	UV excision repair protein RAD23 homolog B [OS=Mus musculus]	24.844	25	7	64	6	416	43.5	protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes	cytosol;nucleus;other cell component	nucleic acid binding activity;other molecular function	19359	ENSMUSG00000028426	Rad23b	mmu:19359; P54728; Q3TUA4		DNA Damage Recognition in GG-NER; Formation of Incision Complex in GG-NER; N-glycan trimming in the ER and Calnexin/Calreticulin cycle; Josephin domain DUBs	0.163261799344377	0.161306887342426	0.239869574315128	0.717436137133365	0.974036928885484	0.876427677263803	0.759759874570384	0.290855344078919		36035.6269067213	6636.01629075847	895160.748716999	822305.884939783	746337.371532698	353804.644267508	266194.248558175	544322.144071712	1505466.3531362	1193974.43213313	959672.229371913	271699.600415343	203995.338678634	316654.755877611
P50580	Proliferation-associated protein 2G4 [OS=Mus musculus]	25.786	25	8	50	8	394	43.7	RNA metabolism OR transcription;other metabolic processes;other biological processes	nucleus;other cell component	nucleic acid binding activity;other molecular function	18813	ENSMUSG00000025364	Pa2g4	mmu:18813; P50580		Neutrophil degranulation	0.779560056573251		0.964376683768043	0.633685073416418	0.85271451854395	0.947247164456515	0.972997624596183	0.875615554962516	44196.81208512	22624.5265168754	65103.4476757493	407149.253420268	351805.238977983	283102.195436615	131699.265080243	188863.083340513	190541.258514689	1366439.32131075	973705.915952878	841970.133977328	277698.771679639	151947.476824751	439777.08198291
Q91YR1	Twinfilin-1 [OS=Mus musculus]	35.22	25	8	58	8	350	40.1	cell organization and biogenesis;other biological processes	cytosol;cytoskeleton;other cell component	cytoskeletal activity;kinase activity;other molecular function	19230	ENSMUSG00000022451	Twf1	mmu:19230; O09132; Q52L77; Q80X09; Q91YR1		RHOBTB2 GTPase cycle			0.469112426270233		0.775009873850764	0.930664206870897	0.99226422416209	0.494759647278835		7074.42642796963	6475.73710910115	194322.084163594	185437.197727591	126936.269216819	52651.4693113549	36978.3724135317	146365.876323787	687471.707239806	527322.308477863	509722.663165187	59742.0337737429	50221.1638882172	53192.547719806
Cont_Q7Z794	Keratin, type II cytoskeletal 1b OS=Homo sapiens OX=9606 GN=KRT77 PE=1 SV=3	55.616	25	15	237	9	578	61.9	cell organization and biogenesis;other biological processes	plasma membrane;cytosol;cytoskeleton	bone, tooth or skin structural activity	374454	ENSG00000189182	KRT77	hsa:374454; Q7RTS8; Q7Z794		Formation of the cornified envelope	0.670774171093686	0.642552559315234	0.554010322700456	0.862605597436246	0.463979702440382	0.900334730044572	0.442703294495121	5.28134115263323E-6	482939.555773679	489805.591490622	650419.199729343	575956.560136537	559902.511082041	544727.937850458	451188.395364125	374442.371861692	438949.756777182	446519.61383744	332998.497796007	326967.436405448	2917805.91835809	914898.376796744	648203.766059372
Q922B2	Aspartate--tRNA ligase, cytoplasmic [OS=Mus musculus]	27.068	25	11	33	11	501	57.1	protein metabolism;RNA metabolism OR transcription;other metabolic processes	cytosol;other cell component	nucleic acid binding activity;other molecular function	226414	ENSMUSG00000026356	Dars1	mmu:226414; Q3U987; Q922B2	Alanine and aspartate metabolism	Transcriptional and post-translational regulation of MITF-M expression and activity	0.846445305003408	0.458134441049542	0.782150551198507	0.803884881697277	0.916283277860523	0.457040324476823	0.877702278315835	0.999950801685853	8228.50432715417		18570.218837201	140800.977365221	195347.934723591	76762.8730665121	61923.7774186535	37359.9503269534	228732.141601315	587682.762372878	525682.945630412	448090.15345378	194399.219185858	97580.3061495578	139135.043371213
P98063	Bone morphogenetic protein 1 [OS=Mus musculus]	76.157	25	21	169	20	991	111.6	protein metabolism;developmental processes;signal transduction;other biological processes	ER/Golgi;other cell component	signal transduction activity or receptor binding;other molecular function	12153	ENSMUSG00000022098	Bmp1	mmu:12153; P98063; Q6NZM2	Adipogenesis genes	Collagen biosynthesis and modifying enzymes; Crosslinking of collagen fibrils; HDL assembly; Anchoring fibril formation	0.752046261550603	0.994542145304377	0.780350581764638	0.241705167061995	0.258012123551448	0.783910800136359	0.385343509994564	0.991920467781922	22555.4003147569	55039.5279519472	116156.455738234	3871398.57924954	4301572.44672203	4632591.23336954	2064007.89192057	1531286.7932063	1778547.49661653	2589653.9540199	2406477.31706772	1563117.05020093	952763.82816532	1574190.4651764	1289187.97296207
Cont_P00698	Lysozyme C OS=Gallus gallus OX=9031 GN=LYZ PE=1 SV=1	14.519	24	3	6	3	147	16.2	other metabolic processes;stress response;other biological processes	non-structural extracellular;ER/Golgi;other cell component	other molecular function	396218	ENSGALG00010011983	LYZ	B8YJN9; B8YJP1; B8YJT7; B8YK79; gga:396218; P00698; Q90884		Neutrophil degranulation; Antimicrobial peptides; Lactose synthesis	0.714071857030863	0.488095179843139	0.482163721239122	0.871109156531165	0.80604799651687	0.835251378529265	0.614016282870324	0.468531677746422	99875.8320506668	62995.8909525794	99338.5926508091	2083102.00788935	121436.892538314	85635.5536079106	82995.1223508219	49598.5151705539	143909.099435799	147080.612620303	392092.113934253	98928.2118024074	133613.647466003	295862.951269409	162275.612700361
P0CW02	Lymphocyte antigen 6C1 [OS=Mus musculus]	3.058	24	2	3	2	131	14.2		plasma membrane;other membranes;other cell component		17067	ENSMUSG00000079018	Ly6c1	mmu:17067; P09568; P0CW02; Q58E40; Q8C2D8; Q91XG0					1.50457038391225E-17	1.70336894001643E-17	6.99442896935933E-17		5.0092807424594E-17	0.924682711624237											10998.3461089193	13775.701285987	5287.20324892146
O88544	COP9 signalosome complex subunit 4 [OS=Mus musculus]	25.645	24	8	47	8	406	46.3	protein metabolism;other metabolic processes	ER/Golgi;nucleus		26891	ENSMUSG00000035297	Cops4	mmu:26891; O88544		Neddylation; DNA Damage Recognition in GG-NER; Formation of TC-NER Pre-Incision Complex; Cargo recognition for clathrin-mediated endocytosis; RHOBTB1 GTPase cycle	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.938859506774495	0.848119069115724	0.98591293207326	0.622877183341601				236602.711152058	267461.680011708	213561.177932515	63967.7287428174	58750.3392130307	130664.031773059	680918.135822014	599089.869910306	457816.34945618	69959.5147376868	31804.3503137729	90348.951843143
Q62465	Synaptic vesicle membrane protein VAT-1 homolog [OS=Mus musculus]	35.931	24	7	52	7	406	43.1	other biological processes	other membranes;mitochondrion	other molecular function	26949	ENSMUSG00000034993	Vat1	mmu:26949; Q62465; Q8R3G0; Q8R3T8		Neutrophil degranulation	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.780750483176003	0.652165153891252	0.388111386240804	0.8084638664687				317207.456592303	422991.833357155	175733.566027084	57836.2141368742	53538.2749981122	101018.090238301	1028056.24220878	882799.889642843	780592.185711911	248020.911638001	187897.250739592	372361.382195658
P46664	Adenylosuccinate synthetase isozyme 2 [OS=Mus musculus]	36.241	24	8	40	8	456	50	other metabolic processes;other biological processes	cytosol;mitochondrion	other molecular function	11566	ENSMUSG00000015961	Adss2	mmu:11566; P46664; Q9CQL9	Purine metabolism	Purine ribonucleoside monophosphate biosynthesis	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.577989402009442	0.795351011232032	0.818770347566052	0.896996950298791				347326.370455884	401368.705633951	302290.700940265	186694.936709668	157200.558091071	210923.761989908	213692.806685804	243283.437713176	208893.46499584	25163.5958512939		35362.5719601795
Cont_Q05443	Lumican OS=Bos taurus OX=9913 GN=LUM PE=1 SV=1	22.975	24	7	64	7	342	38.7		non-structural extracellular;extracellular matrix	other molecular function	280847	ENSBTAG00000001745	LUM	bta:280847; Q05443; Q3T0T2		Keratan sulfate biosynthesis; Keratan sulfate degradation; Integrin cell surface interactions	0.424134839863131	0.735422810404275	0.455985225276046	0.407032230614587	0.934852211695135	0.220414227350379	0.537994146581402	0.379417433613785	571697.052131806	533388.288926757	217347.605662138	361000.258086964	394869.959952486	298893.199185548	470255.374122116	424715.908609543	465208.319262024	450355.812894958	588685.639885882	392572.151998672	210924.957116738	240784.805196184	575454.457833053
Q03265	ATP synthase subunit alpha, mitochondrial [OS=Mus musculus]	42.599	24	11	89	11	553	59.7	other metabolic processes;transport;other biological processes	plasma membrane;other membranes;mitochondrion;other cell component	signal transduction activity or receptor binding;transporter activity;other molecular function	11946	ENSMUSG00000025428	Atp5f1a	mmu:11946; Q03265; Q3TFN0; Q3THN8; Q3TPR0; Q3TPV3; Q3TZU3; Q3UIR7; Q543Y6	Oxidative phosphorylation; Electron transport chain	Mitochondrial protein degradation; Formation of ATP by chemiosmotic coupling; Cristae formation	0.47561863521241	0.412437655906212	1.50457038391225E-17	0.0919777278620784	0.606549315086283	0.974566146657098	0.0485737723533946	0.446373701238047		9055.96500118803	15464.3989435778	427973.735878753	664100.473443731	535386.604489899	355236.428175408	248936.397429607	189564.4709508	2148034.05023863	2035695.95276082	1488373.41168965	1411586.25913922	1149183.70245697	1357675.97952806
Q8CFG9	Complement C1r-B subcomponent [OS=Mus musculus]	74.361	24	12	125	1	706	79.9	protein metabolism;stress response;other biological processes	non-structural extracellular	other molecular function	667277	ENSMUSG00000098470	C1rb	mmu:667277; Q8CFG9			1.65082956259427E-17		1.50457038391225E-17	1.70336894001643E-17	0.957324015670425	5.07936507936508E-17	5.0092807424594E-17	0.30534923332927					34601.3294531986					51357.1770695822	68906.0705366989	59823.4441546508			65104.8269614353
Q62422	Osteoclast-stimulating factor 1 [OS=Mus musculus]	5.452	24	3	14	3	215	23.8		other cell component	other molecular function	20409	ENSMUSG00000024725	Ostf1	mmu:20409; Q3UF05; Q62422		Neutrophil degranulation	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17		0.916283277860523	0.983440558239231	5.0092807424594E-17	5.71658986175115E-17					52887.6067655068	52454.7733758452		30908.1241040931		95117.1994231789	98401.5083095326	126048.341738986
Cont_P56652	Inter-alpha-trypsin inhibitor heavy chain H3 OS=Bos taurus OX=9913 GN=ITIH3 PE=1 SV=2	81.862	24	18	248	18	891	99.5	other metabolic processes	non-structural extracellular	enzyme regulator activity	508355	ENSBTAG00000007846	ITIH3	A7MB92; bta:508355; P56652; Q0V8M9		Platelet degranulation	0.483779141493222	0.806123482822196	0.999577296233586	0.997751268638055	0.472773884020904	0.167300285011781	0.850760367544917	0.347110071538929	3610198.20085413	3274629.10628763	2185054.24358411	2537384.93999894	2738382.5247637	2073191.27933329	3945768.45043609	3580368.74998687	4341482.44088309	1.00570334694978E7	1.00821692412717E7	7186093.0176279	6100921.67287855	6132897.59444828	1.00056755277436E7
Q9CPY7	Cytosol aminopeptidase [OS=Mus musculus]	43.369	24	11	68	11	519	56.1	protein metabolism	ER/Golgi	other molecular function	66988	ENSMUSG00000039682	Lap3	mmu:66988; Q3TFS5; Q4FJV1; Q4FK15; Q99P44; Q9CPY7; Q9CWN8	Oxidative stress and redox pathway		0.399146196820048		0.480528264992746		0.829717100259376	0.864215513767001	0.985707795620743	0.684917106202847		6327.30251135897		455399.894921951	999375.734609643	1213817.02278234	543767.623288322	271880.795204531	465268.769998681	918602.905871554	1006383.64749623	841695.831622124	343376.623758697	251120.129926048	478548.96184005
Q9Z1D1	Eukaryotic translation initiation factor 3 subunit G [OS=Mus musculus]	22.471	24	6	44	6	320	35.6	cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes	cytosol;translational apparatus;nucleus;other cell component	nucleic acid binding activity;other molecular function	53356	ENSMUSG00000070319	Eif3g	mmu:53356; Q9R079; Q9Z1D1	Translation factors; mRNA processing	L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.957324015670425	0.904392641853656	0.95208150302084	0.923565102983619				323173.635282816	287550.143379904	110604.838421903	70696.0467158332	92303.8426518731	225386.180702119	609827.628144167	514703.535592577	401179.110223089	149027.849778415	144589.04250416	130901.011027427
P61087	Ubiquitin-conjugating enzyme E2 K [OS=Mus musculus]	19.001	24	4	43	4	200	22.4	cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes	nucleus;other cell component	other molecular function	53323	ENSMUSG00000029203	Ube2k	mmu:53323; O54806; P27924; P61087; Q16721; Q9CVV9		Antigen processing: Ubiquitination & Proteasome degradation; Synthesis of active ubiquitin: roles of E1 and E2 enzymes	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.916283277860523	0.918676345941662	0.837231569641376	0.938282411159324				414785.301280776	363909.607069903	194709.045705451	89975.258608923	57445.9934333516	174815.870273971	238651.856391741	496143.882717363	292433.577961202	97516.436185985	29525.3961628472	175831.035060396
P01942	Hemoglobin subunit alpha [OS=Mus musculus]	8.245	24	3	28	2	142	15.1	transport;developmental processes;other biological processes	cytosol	other molecular function			Hba	P01942		Scavenging of heme from plasma; Cytoprotection by HMOX1; Erythrocytes take up carbon dioxide and release oxygen; Erythrocytes take up oxygen and release carbon dioxide; Heme signaling	0.247814911744363	0.338635449371676	0.12314783295876	0.308661659682749	0.577326326766933	0.254381747765851	0.870511801558508	0.0577829304397721	191454.152734224	181051.877573676	208165.319242361	92658.2910344896	66013.9097866877	87635.3074131074	106819.174964116	116534.031985882	89588.1859596122	47865.0444128016	59805.5906674051	22096.1940008488	56084.306765531	144850.822097133	65344.4651707797
O35226	26S proteasome non-ATPase regulatory subunit 4 [OS=Mus musculus]	25.917	24	5	21	5	376	40.7		cytosol;nucleus;other cell component	other molecular function	19185	ENSMUSG00000005625	Psmd4	mmu:19185; O35226; Q91V59; Q9JJM0; Q9JJM1; Q9JJM2; Q9JJM3	ID signaling pathway; Proteasome degradation	Proteasome assembly	0.889562692156463	0.896787359697595	0.730324052254867	0.848853682081225	0.919000011234851	0.419227135335989	0.7936009903402	0.321093701658685	18334.3334108854	15329.3009358247	11730.6285076259	68352.2625038413	4235.55595423704	31150.8570286062	37402.4131699345	24323.5199633347		90068.6102057068	80668.3735135531	132602.737906579	16992.4483318743	27013.793900845	29276.0748579686
Q8JZQ9	Eukaryotic translation initiation factor 3 subunit B [OS=Mus musculus]	59.873	24	16	97	16	803	91.3	cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes	translational apparatus;other cell component	nucleic acid binding activity;other molecular function	27979	ENSMUSG00000056076	Eif3b	mmu:27979; Q8JZQ9; Q922K2	Translation factors; mRNA processing; IL-2 signaling pathway	L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition	0.313672901481097	0.647757396099182	0.79852304377905	0.930955411749965	0.976873891151678	0.983440558239231	0.958705855138011	0.950507099097121	2817771.54640953	2168931.1456962	3344824.99754576	2315794.59228753	1632672.27130637	1744271.90507133	2275064.35301455	2836283.30339529	2183383.13613268	2796750.77822989	2090402.41211428	2747809.4650168	5703731.86210323	8678765.25578011	3565861.84270347
O09164	Extracellular superoxide dismutase [Cu-Zn] [OS=Mus musculus]	33.482	24	4	63	4	251	27.4	other metabolic processes;stress response	non-structural extracellular;ER/Golgi	other molecular function	20657	ENSMUSG00000072941	Sod3	mmu:20657; O09164	One-carbon metabolism and related pathways; Oxidative stress response; Oxidative stress and redox pathway	Detoxification of Reactive Oxygen Species	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.185102114341304	0.860508330323499	0.0267601102468926	0.838865076180761				1218554.68836703	1056749.2188137	1428937.3113448	1319103.45852322	905541.408505281	887434.799047666	670435.626404648	411168.531998097	332400.64112778	172238.897599962	83163.6185475475	247737.10732068
P54071	Isocitrate dehydrogenase [NADP], mitochondrial [OS=Mus musculus]	32.566	24	10	47	9	452	50.9	other metabolic processes;other biological processes	cytosol;other cytoplasmic organelle	other molecular function	269951	ENSMUSG00000030541	Idh2	mmu:269951; P54071; Q8C2R9; Q9EQK1	TCA cycle; Oxidative stress and redox pathway	Mitochondrial protein degradation; Maturation of TCA enzymes and regulation of TCA cycle; Citric acid cycle (TCA cycle); Transcriptional activation of mitochondrial biogenesis	0.756307781015079	0.831177999662531	0.183728086065793	0.138185243719646	0.235385083363878	0.93967990867893	0.00608766876792646	0.672985746285079	24213.6379511047	45656.02972236	34942.6793841601	91949.9586212689	139806.360275936	98585.0127861689	45321.9231535779	49946.8618472953	91192.303483228	1399003.17557104	1388602.62422745	1043789.98129773	902655.893623655	757353.187346743	918368.458509137
P24472	Glutathione S-transferase A4 [OS=Mus musculus]	12.924	24	6	71	6	222	25.5	other metabolic processes;stress response	mitochondrion	other molecular function	14860	ENSMUSG00000032348	Gsta4	mmu:14860; P24472; Q9CQ81; Q9CTY7; Q9CY87; Q9D038	Metapathway biotransformation; Oxidative stress and redox pathway		0.0565568600489038	0.106456338139748	0.125240606972741	0.218357577911048	0.736189738251305	0.372554591303947	0.97925982662951	0.954396180425051	13404.6396702358			1330899.98570853	1492069.50376569	2165812.43435646	495077.209478359	405041.052026421	634993.373761934	1505562.65714851	1580275.47656253	1195874.16996752	492112.89193748	337647.636565074	873589.61271386
Q9WUU7	Cathepsin Z [OS=Mus musculus]	24.675	24	7	88	7	306	34	protein metabolism;developmental processes;other biological processes	non-structural extracellular;ER/Golgi;other cytoplasmic organelle;other cell component	other molecular function	64138	ENSMUSG00000016256	Ctsz	mmu:64138; Q9WUU7		Neutrophil degranulation; Metabolism of Angiotensinogen to Angiotensins; COPII-mediated vesicle transport; Cargo concentration in the ER; Lysosome Vesicle Biogenesis	0.719390389096947	0.29127820820895	0.809948223138506	0.963689578772028	0.946568086066385	0.835500381599154	0.896866816139962	0.780352569351336	8920.36670696029			557439.372968213	537497.14483075	916195.796244702	614169.667033189	425422.33445426	592949.964111346	1364707.36249504	943060.241971029	722653.93128105	375630.349946779	473597.412381281	640899.779663527
P24527	Leukotriene A-4 hydrolase [OS=Mus musculus]	43.95	24	12	56	12	611	69	protein metabolism;other metabolic processes;developmental processes;other biological processes	cytosol;nucleus	other molecular function	16993	ENSMUSG00000015889	Lta4h	mmu:16993; P24527; Q3UY71; Q8VDR8	Eicosanoid synthesis	Neutrophil degranulation; Synthesis of Leukotrienes (LT) and Eoxins (EX); Biosynthesis of D-series resolvins; Biosynthesis of E-series 18(S)-resolvins; Biosynthesis of aspirin-triggered D-series resolvins; Biosynthesis of E-series 18(R)-resolvins; Biosynthesis of protectins	0.765059840458438	0.874746860236967	0.49027994509233	0.743086654540196	0.964629994744883	0.835847993497856	0.92065730582581	0.0362061827154888	317064.751146117	321526.217792638	335572.240914384	1355275.41702564	747553.611904229	434807.613340348	462402.248269767	392610.689445021	1049487.81755911	870050.021344262	863600.714781144	634221.331276601	291534.898141417	1338395.70903956	535593.297653157
P51125	Calpastatin [OS=Mus musculus]	69.232	24	12	68	12	788	84.9	protein metabolism;other metabolic processes	other membranes	enzyme regulator activity	12380	ENSMUSG00000021585	Cast	mmu:12380; P51125; Q9EQV4; Q9EQV5; Q9QXQ3; Q9QXQ4; Q9R0N1		Degradation of the extracellular matrix	0.964987088717195	0.88049510338207	0.878011012613722	0.811642495923494	0.930240378222147	0.414106612795217	0.977853974998917	0.922473072882184	23239.5159446653	57629.4913619143		278079.161125981	312738.288971595	266069.844145655	29249.5483399929	19425.0495082317	118186.785036988	539224.428591468	560231.293429647	435174.529095517	123589.259981795		155069.58408147
Cont_Q3T052	Inter-alpha-trypsin inhibitor heavy chain H4 OS=Bos taurus OX=9913 GN=ITIH4 PE=1 SV=1	63.951	24	17	211	17	916	101.4	other metabolic processes;stress response	non-structural extracellular	enzyme regulator activity	513700		ITIH4	bta:513700; Q3T052			0.621706543772502	0.835972967161612	0.644088679644979	0.489081840029873	0.944154202827561	0.373292142753803	0.638748509735888	0.61860455621556	5819813.47342044	5492574.86981349	4055903.39519301	5754122.59685596	7324312.67809606	4577907.88712478	6019550.22472971	7241787.31545172	7435267.30027669	8186643.56265156	8330632.76486492	5347012.24577932	3910433.70750151	3129102.47305808	7828236.65139127
Q63810	Calcineurin subunit B type 1 [OS=Mus musculus]	11.455	24	3	18	3	170	19.3	transport;developmental processes;signal transduction;other biological processes	plasma membrane;other membranes;cytosol;other cell component	other molecular function	19058	ENSMUSG00000033953	Ppp3r1	mmu:19058; Q3V067; Q5F225; Q63810	Alzheimer's disease; Mapk signaling pathway	FCERI mediated Ca+2 mobilization; Ca2+ pathway; Activation of BAD and translocation to mitochondria ; Calcineurin activates NFAT; CLEC7A (Dectin-1) induces NFAT activation	1.65082956259427E-17		1.50457038391225E-17	1.70336894001643E-17	0.830676695521175	5.07936507936508E-17	5.0092807424594E-17	0.311875695346484				10984.4856667982	12460.5789473767	8769.25656039555				56055.8882649845	24814.1935664919	45911.3071020784	3782.16251575939		7953.30918246313
Q9D1J3	SAP domain-containing ribonucleoprotein [OS=Mus musculus]	15.601	23	4	18	4	210	23.5	other metabolic processes;transport;other biological processes	nucleus;other cell component	nucleic acid binding activity;other molecular function	66118	ENSMUSG00000078427	Sarnp	mmu:66118; Q3UJZ4; Q9CU18; Q9D1J3		Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.873755746039336	0.802315371714662	0.988377544628277	0.271567379709816				62159.7581388464	59793.1937610154	78349.6025752407	19247.8584584453		38047.9092522021	277464.81193496	290705.645223752	209712.840521915	38733.4381009489
Q80UG5	Septin-9 [OS=Mus musculus]	37.398	23	13	83	13	583	65.5	cell organization and biogenesis;other biological processes	cytoskeleton;other cell component	other molecular function	53860	ENSMUSG00000059248	Septin9	A2A6U2; A2A6U4; A2A6U6; mmu:53860; Q3URP2; Q80TM7; Q80UG5; Q9QYX9			0.988333036183619	0.887421928344782	0.530172281859222	0.960067650286237	0.749722062153876	0.877818946381645	0.933437821008547	0.853273978801687	17714.4408117179			427964.36292887	484344.543647168	179108.830804391	34457.7794665346	10323.0930817895	118450.806324343	1451160.37896266	1368083.05628556	1031668.68024223	306265.177604722	243812.765643986	372564.753796198
Q8BHN3	Neutral alpha-glucosidase AB [OS=Mus musculus]	64.856	23	17	179	17	944	106.8	protein metabolism;other metabolic processes	ER/Golgi;other cell component	other molecular function	14376	ENSMUSG00000071650	Ganab	mmu:14376; O08794; Q149A6; Q80U81; Q8BHN3; Q9CS53		Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	0.132235255618832	0.85271451854395	0.877818946381645	0.846117085258013	0.753667778711186	39103.4693126544		31118.9986111295	2601514.77777162	3086884.48924841	2255433.39472673	2046845.45395459	1898721.67880566	2787373.50419326	3068642.93276463	2869917.53495465	2127831.62046594	1427702.82164542	856038.819205018	2294782.34345632
Q9JIW9	Ras-related protein Ral-B [OS=Mus musculus]	17.96	23	3	12	3	206	23.3	stress response;transport;signal transduction;other biological processes	plasma membrane;other membranes;other cell component	other molecular function	64143	ENSMUSG00000004451	Ralb	mmu:64143; Q3TVS5; Q9JIW9	EGFR1 signaling pathway		1.65082956259427E-17		1.50457038391225E-17	1.70336894001643E-17	0.854305439376382	5.07936507936508E-17	5.0092807424594E-17	0.922371057250263						33491.7077057599				163669.056552603	87066.7079498729	176144.135727898	47865.7730491222		32548.7155137476
Q8C180	Fibroblast growth factor receptor substrate 2 [OS=Mus musculus]	33.564	23	9	49	9	508	56.8	cell cycle OR cell proliferation;developmental processes;signal transduction;other biological processes	plasma membrane;other membranes;cytosol;other cell component	signal transduction activity or receptor binding	327826	ENSMUSG00000020170	Frs2	mmu:327826; Q8C180	BDNF pathway	RND2 GTPase cycle; RAF/MAP kinase cascade; PIP3 activates AKT signaling; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; RET signaling; PI3K Cascade; PI-3K cascade:FGFR1; FRS-mediated FGFR1 signaling; Negative regulation of FGFR1 signaling; PI-3K cascade:FGFR2; FRS-mediated FGFR2 signaling; Negative regulation of FGFR2 signaling; FRS-mediated FGFR4 signaling; PI-3K cascade:FGFR4; Negative regulation of FGFR4 signaling; FRS-mediated FGFR3 signaling; PI-3K cascade:FGFR3; Negative regulation of FGFR3 signaling; Activated NTRK2 signals through FRS2 and FRS3; RND1 GTPase cycle; Frs2-mediated activation	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.957324015670425	0.941920360687835	0.959009572701759	0.992875942228012				92915.9403696821	154164.313160986	207340.392660486	13625.1955135124	50754.6790404038	55322.7354824269	537711.362519393	527455.911916829	297574.917162927	21442.9592186793	42877.7766612506	130641.408149432
Q62446	Peptidyl-prolyl cis-trans isomerase FKBP3 [OS=Mus musculus]	12.077	23	5	32	5	224	25.1		nucleus	other molecular function	30795	ENSMUSG00000020949	Fkbp3	mmu:30795; Q62446; Q9WTJ7			0.816765173976368		0.646232544613082		0.977025722891822	0.687563254285224	0.95208150302084	0.869311323615184	17941.3540684969		20850.7091170911	224654.949806012	265736.287249014	257127.363185323	91118.3400716317	44507.4679290976	105776.387254448	545495.222977087	375575.539411904	295127.402709293	68401.1838448348	69240.4964316517	71779.2137521193
P61957	Small ubiquitin-related modifier 2 [OS=Mus musculus]	14.668	23	2	40	1	95	10.9	protein metabolism;other metabolic processes;other biological processes	cytosol;nucleus;other cell component	other molecular function	170930	ENSMUSG00000020738	Sumo2	A2A9X2; mmu:170930; P55855; P61957; Q542L8		SUMOylation of DNA damage response and repair proteins; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Processing of DNA double-strand break ends; Formation of Incision Complex in GG-NER; SUMOylation of transcription cofactors; Vitamin D (calciferol) metabolism; SUMOylation of transcription factors; SUMOylation of intracellular receptors; SUMO is proteolytically processed	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.976873891151678	0.963639387975665	0.872243592918475	0.867637622249601				569216.246653163	488354.140787472	537684.625312054	480114.486149273	219017.597600213	473879.748966659	876737.005200859	749081.159186621	548486.192595657	240320.393328557	143423.301427049	293124.165039954
Q64191	N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase [OS=Mus musculus]	28.448	23	5	27	5	346	37	protein metabolism	non-structural extracellular;ER/Golgi;other cytoplasmic organelle	other molecular function	11593	ENSMUSG00000031521	Aga	mmu:11593; Q64191		Neutrophil degranulation	0.517392529334842	0.301181868500084	0.241517105970708	0.235618814013137	0.906018817980367	0.97527107273228	0.337576679020802	0.273615321023081	29845.6592362317		1718.51996294124	203362.515179677	67003.3435232404	192929.339286224	78566.9750728175	23977.5155374211	94597.1090397847	404521.061714102	199065.498110366	570800.116629316	327064.522939295	210518.03260255	41314.3668843746
Q8K4Z3	NAD(P)H-hydrate epimerase [OS=Mus musculus]	22.515	23	4	16	4	282	31	cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes	non-structural extracellular;cytosol;mitochondrion;nucleus;other cell component	other molecular function	246703	ENSMUSG00000028070	Naxe	mmu:246703; Q8K4Z3		Nicotinate metabolism	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.889445903483421	0.941920360687835	0.394949139624895	0.953305976192702				131429.52734851	135011.870540785	33272.3141852838	58915.0544612484	47853.8755851873	70514.9667024239	315961.639834853	325589.467804419	223226.205373016	133549.21796528	77444.1528545642	195008.627508543
Q8K4Q8	Collectin-12 [OS=Mus musculus]	29.112	23	12	72	12	742	81.3	cell organization and biogenesis;stress response;transport;signal transduction;other biological processes	other membranes;other cell component	other molecular function	140792	ENSMUSG00000036103	Colec12	mmu:140792; Q3TYT8; Q8C979; Q8K4Q8; Q8VIF6			0.176054282234449	0.0779943270068697	0.530172281859222	0.635198784401077	0.0907041801657065	0.900334730044572	0.603396113384508	0.166451722850835		26337.7409724648	11582.7307664804	3619155.85618343	1962094.55120787	1866452.61832682	890431.924181766	963606.152998873	1137490.9653188	537816.287234222	450519.994950561	631285.451354063	755537.807401353	143532.893722796	349172.53822931
P19096	Fatty acid synthase [OS=Mus musculus]	203.372	23	48	335	48	2504	272.3	other metabolic processes;stress response;other biological processes	plasma membrane;other membranes;cytosol;ER/Golgi;other cell component	other molecular function	14104	ENSMUSG00000025153	Fasn	B1ATU8; mmu:14104; P19096; Q6PB72; Q8C4Z0; Q9EQR0	Fatty acid biosynthesis; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-9 fatty acid synthesis; Elongation of (very) long chain fatty acids	Fatty acyl-CoA biosynthesis; Vitamin B5 (pantothenate) metabolism	0.66189768147619	0.847457711018997	0.951921622352553	0.605074788683686	0.87421335771164	0.994834213681465	0.746782404466558	0.990873516209569	48161.514825801		157425.136778521	3018838.26514359	3331564.42510829	1838171.31939824	1125050.80259593	1067574.24276956	1976727.22395058	3354008.01034064	3348654.9716265	2283763.91979924	908323.020723558	618361.207888453	1151575.74161029
Q9D6X6	Serine protease 23 [OS=Mus musculus]	29.72	23	6	59	6	382	43	protein metabolism	nucleus	other molecular function	76453	ENSMUSG00000039405	Prss23	mmu:76453; Q544M8; Q8VEG1; Q9D6X6		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.205516536258876	0.764791307960872	0.0435532390180777	0.896996950298791				974154.519002871	869088.371579952	857352.591035892	701757.434510282	693696.530336521	803834.47852482	383804.738296797	528487.606166628	400701.115296265	117950.978961181		134791.310627643
P70349	Adenosine 5'-monophosphoramidase HINT1 [OS=Mus musculus]	9.966	23	3	31	3	126	13.8	protein metabolism;other metabolic processes;signal transduction;other biological processes	plasma membrane;other membranes;cytosol;nucleus;other cell component	other molecular function	15254	ENSMUSG00000020267	Hint1	mmu:15254; P70349		Transcriptional and post-translational regulation of MITF-M expression and activity; Regulation of MITF-M-dependent genes involved in apoptosis; Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	0.385416319196753	0.5873993213501	0.258650898052408	0.681369750462592	0.938859506774495	0.797858239267722	0.962266405871615	0.659567728531141	90352.8374144931	128530.034819013	105744.676397804	1000621.4820998	1036539.42655946	946421.335909117	442498.457162874	383780.056672564	583114.662277273	2274471.76104267	1986325.74689238	1516598.94151118	473257.816814805	572487.622267088	715494.771395363
Q9CZ30	Obg-like ATPase 1 [OS=Mus musculus]	26.088	23	8	65	8	396	44.7	other metabolic processes	cytosol;cytoskeleton;nucleus	translation activity;other molecular function	67059	ENSMUSG00000027108	Ola1	B1AYJ8; B1AYK0; mmu:67059; Q9CWE2; Q9CX91; Q9CYC9; Q9CZ30; Q9CZ56		Platelet degranulation	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.957324015670425	0.97504218639442	0.866766165039268	0.869792271407368			4319.56370558109	538916.220312884	716540.355687793	779356.508776979	404976.241075076	251558.546891063	421331.607121691	1336590.37155973	1302361.48710026	1148063.57149187	506167.7157943	249715.423488668	722117.47785393
Q8VBV7	COP9 signalosome complex subunit 8 [OS=Mus musculus]	7.604	23	3	11	3	209	23.2	cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes	cytosol;nucleus;other cell component		108679	ENSMUSG00000034432	Cops8	mmu:108679; Q3TRS9; Q80XF4; Q8R4D2; Q8VBV7		Cargo recognition for clathrin-mediated endocytosis; Neddylation; DNA Damage Recognition in GG-NER; Formation of TC-NER Pre-Incision Complex	1.65082956259427E-17		1.50457038391225E-17	1.70336894001643E-17	0.938859506774495	5.07936507936508E-17	5.0092807424594E-17	0.896996950298791				44207.70985292	75719.4599664041	54150.8777076421				158332.16994087	231267.17737025	184309.582653216			11545.3638081293
Cont_P01045	Kininogen-2 OS=Bos taurus OX=9913 GN=KNG2 PE=1 SV=1	66.141	23	14	238	3	619	68.7	stress response;other biological processes	non-structural extracellular	enzyme regulator activity	280833		KNG2	bta:280833; P01045; P01047			0.844083503707515	0.897648209661015	0.880379766732388	0.56094761305	0.482368386142793	0.890115756735749	0.579706236112957	0.954396180425051	263337.684014512	315196.036486147	382141.872455649	637318.246298499	804477.434563105	913331.150461836	403323.074484479	411792.369154177	344397.281688611	974418.228278592	833063.390439139	385134.380779166	110194.651545581	50080.5066249887	383998.142169506
Q91VM5	RNA binding motif protein, X-linked-like-1 [OS=Mus musculus]	20.881	23	9	44	9	388	42.1	cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes	non-structural extracellular;nucleus;other cell component	nucleic acid binding activity;other molecular function	19656	ENSMUSG00000037070	Rbmxl1	mmu:19656; O35479; Q91VM5	mRNA processing		0.755347156149166	0.702088113519195	0.600277477019654	0.828041718447237	0.709229396391097	0.767326422376928	0.8257846014245	0.35292744698975	28739.6174242265	25094.1175973712	23585.3974712863	492777.056626389	472210.866631383	394620.74982825	92106.350007264	154361.547582717	224213.865427178	1754428.54689709	1384395.25089657	955943.385777657	291051.880192963	206390.637520907	271063.988683011
P10833	Ras-related protein R-Ras [OS=Mus musculus]	12.732	23	4	19	2	218	23.7	developmental processes;signal transduction;other biological processes	plasma membrane;other membranes;cytosol	other molecular function	20130	ENSMUSG00000038387	Rras	mmu:20130; P10833	Mechanisms associated with pluripotency; G protein signaling pathways; Mapk cascade; Novel Jun-Dmp1 pathway; Regulation of actin cytoskeleton	Sema4D mediated inhibition of cell attachment and migration		0.112603270007904	0.765323905326321	0.641234093853536	0.779252881438118	0.901056551888415	0.707244953745288	0.972345234491607	20603.7650274229			53060.1964777742	64370.876216758	71519.1321359076	30769.7241811911	39152.2289525888	45688.3938649593	232204.957244242	291313.179937111	159421.476735733	78410.3492795794	78661.7212146753	118865.861443805
Q922F4	Tubulin beta-6 chain [OS=Mus musculus]	42.068	23	8	103	2	447	50.1	cell organization and biogenesis;other biological processes	cytoskeleton;other cell component	cytoskeletal activity;other molecular function	67951	ENSMUSG00000001473	Tubb6	mmu:67951; Q922F4		Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Aggrephagy; MHC class II antigen presentation; COPI-independent Golgi-to-ER retrograde traffic; PKR-mediated signaling; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; COPI-mediated anterograde transport; Recruitment of NuMA to mitotic centrosomes; Intraflagellar transport; Carboxyterminal post-translational modifications of tubulin; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recycling pathway of L1; Hedgehog 'off' state; RHO GTPases activate IQGAPs; Sealing of the nuclear envelope (NE) by ESCRT-III	1.65082956259427E-17		1.50457038391225E-17	1.70336894001643E-17	0.962288617208903	5.07936507936508E-17	5.0092807424594E-17	0.999950801685853				108352.057859711	95331.9352271939	45912.9429219642				132146.420536887	144474.207435899	89943.5644108061	52601.8966400171	93493.4362080257	66340.7148844561
P62281	Small ribosomal subunit protein uS17 [OS=Mus musculus]	9.747	23	4	53	4	158	18.4	protein metabolism;other metabolic processes;other biological processes	cytosol;translational apparatus;nucleus;other cell component	nucleic acid binding activity;other molecular function	27207	ENSMUSG00000003429	Rps11	mmu:27207; P04643; P62281	Cytoplasmic ribosomal proteins; mRNA processing	L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Translation initiation complex formation; Ribosomal scanning and start codon recognition; SRP-dependent cotranslational protein targeting to membrane; Major pathway of rRNA processing in the nucleolus and cytosol; Formation of a pool of free 40S subunits; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Formation of the ternary complex, and subsequently, the 43S complex	0.410805606559185	0.666935701329128	0.226240326944612	0.43868363117689	0.899572969798426	0.86006378226746	0.8933418141599	0.922473072882184	37024.6704821781		35288.860514282	736425.658358351	803296.902982178	537455.801252758	458174.884955589	439376.070835649	654253.039644635	1753872.88136962	1666431.00223358	1231103.84673662	902408.776243112	481287.639108859	888573.385180324
Q9EPL2	Calsyntenin-1 [OS=Mus musculus]	65.056	23	18	154	18	979	108.8	cell adhesion;cell-cell signaling;transport;other biological processes	non-structural extracellular;plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component	cytoskeletal activity;other molecular function	65945	ENSMUSG00000039953	Clstn1	A2A800; B2KFP1; B2KFP2; mmu:65945; Q69ZV9; Q7TS67; Q8K103; Q9EPL2	Splicing factor NOVA regulated synaptic proteins		1.65082956259427E-17	0.0102793307190414	0.253180133129803	0.553772240900005	0.21198788118775	0.941920360687835	0.256114643704363	0.995358155527084	26418.3732999659	10457.2681575461	18743.3649419972	4640334.83607464	4736804.04335908	6607868.40421213	3211444.23907718	2166935.52752448	2896212.07525235	3677922.78222477	2809822.46228407	2108714.6255167	1030029.55943895	924955.240125053	1354978.94277027
Cont_P02070	Hemoglobin subunit beta OS=Bos taurus OX=9913 GN=HBB PE=1 SV=1	11.466	23	3	44	1	145	15.9	other metabolic processes;transport;other biological processes	cytosol;other cell component	other molecular function	280813	ENSBTAG00000038748	HBB	bta:280813; P02070		Cytoprotection by HMOX1; Neutrophil degranulation; Scavenging of heme from plasma; Erythrocytes take up carbon dioxide and release oxygen; Heme signaling; Erythrocytes take up oxygen and release carbon dioxide
Q76MZ3	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [OS=Mus musculus]	30.516	23	11	71	11	589	65.3	cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes	plasma membrane;other membranes;cytosol;nucleus;other cell component	enzyme regulator activity;other molecular function	51792	ENSMUSG00000007564	Ppp2r1a	mmu:51792; Q76MZ3	Mechanisms associated with pluripotency; Focal adhesion: PI3K-Akt-mTOR signaling pathway; Glycogen metabolism; IL-6 signaling pathway; Wnt signaling pathway and pluripotency	Separation of Sister Chromatids; PKR-mediated signaling; Resolution of Sister Chromatid Cohesion; Recruitment of NuMA to mitotic centrosomes; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Negative regulation of MAPK pathway; Cyclin A/B1/B2 associated events during G2/M transition; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Anchoring of the basal body to the plasma membrane; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; AURKA Activation by TPX2; DARPP-32 events; Platelet sensitization by LDL; Initiation of Nuclear Envelope (NE) Reformation; Spry regulation of FGF signaling; RAF activation; Cyclin D associated events in G1; Regulation of TP53 Degradation; Beta-catenin phosphorylation cascade; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Co-stimulation by CD28; Co-inhibition by CTLA4; Inhibition of replication initiation of damaged DNA by RB1/E2F1; ERKs are inactivated	0.0540577758999414	0.297092114730402	1.50457038391225E-17	0.387864398810368	0.914904152026145	0.384794804052606	0.691530066981133	0.804271411426757	43014.0866209833	34319.1667211984	26758.0623766378	893372.10980726	853436.848723082	582276.249278746	157874.952850974	160652.202988367	320216.257431453	2021153.81955689	1755339.23730818	1132604.56993785	353841.990549785	393320.89783789	794704.957531856
Q9DBR7	Protein phosphatase 1 regulatory subunit 12A [OS=Mus musculus]	78.124	23	19	122	18	1029	114.9	cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes	plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component	enzyme regulator activity;other molecular function	17931	ENSMUSG00000019907	Ppp1r12a	mmu:17931; Q05A74; Q8CBV2; Q99NB6; Q9DBR7	Regulation of actin cytoskeleton; Focal adhesion	Regulation of PLK1 Activity at G2/M Transition; RHO GTPases activate PKNs; RHO GTPases activate PAKs	0.642741872950003	0.793823975102705	0.371048917979225	0.927402296662438	0.827306741569751	0.983440558239231	0.97925982662951	0.725153998443568		14038.5497598446		376624.216822088	540897.592928014	90303.340615712	153504.951759291	72124.7711420622	163765.38917868	2184806.1865265	1916814.45492133	1283076.51977746	345764.855486184	140508.043001695	359098.772902973
Q8QZY1	Eukaryotic translation initiation factor 3 subunit L [OS=Mus musculus]	36.297	23	12	70	12	564	66.6	cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes	translational apparatus;nucleus;other cell component	other molecular function	223691	ENSMUSG00000033047	Eif3l	mmu:223691; Q3THF8; Q3TJ04; Q8QZY1; Q91YE4		L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.903011105681797	0.903961701309978	0.958705855138011	0.809503222445875				376757.453110516	557500.813242921	334457.049934335	267291.317808921	207775.152349537	373265.20952022	1136149.63773812	795827.565086988	788938.851032747	251230.186912633	167564.728880226	293461.185809978
Cont_A0A3Q1MJB2	Fibulin-1 OS=Bos taurus OX=9913 GN=FBLN1 PE=1 SV=1	72.631	23	12	183	9	706	77.4	cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes	non-structural extracellular;extracellular matrix	signal transduction activity or receptor binding;enzyme regulator activity;extracellular structural activity;other molecular function		ENSBTAG00000012088	FBLN1	A0A3Q1MJB2			0.951385982865186	0.278049011002068	0.787590521601686	0.802863674292211	0.928294560197876	0.00248796854708363	0.767145247888963	0.286233487508377	954396.726395766	765810.707842343	480584.404006346	1303691.2126037	1754311.77467969	1294323.14036193	3638220.43260457	3452683.23934677	3717238.36403873	3595499.28028515	3346977.34907708	2427119.38215447	1954372.79128714	2098144.98118374	3383005.26945409
P62196	26S proteasome regulatory subunit 8 [OS=Mus musculus]	24.542	23	8	48	7	406	45.6	protein metabolism;other metabolic processes;other biological processes	cytosol;nucleus;other cell component	signal transduction activity or receptor binding;other molecular function	19184	ENSMUSG00000020708	Psmc5	mmu:19184; O35051; P47210; P52915; P52916; P62196; Q3UL51; Q9CWN5	Proteasome degradation	Degradation of CDH1; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Interleukin-1 signaling; Activation of NF-kappaB in B cells; Neddylation; Asymmetric localization of PCP proteins; Degradation of AXIN; Hedgehog 'on' state; Ub-specific processing proteases; Regulation of RUNX3 expression and activity; Autodegradation of Cdh1 by Cdh1:APC/C; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; Assembly of the pre-replicative complex; CDK-mediated phosphorylation and removal of Cdc6; The role of GTSE1 in G2/M progression after G2 checkpoint; MAPK6/MAPK4 signaling; UCH proteinases; Regulation of PTEN stability and activity; ABC-family proteins mediated transport; Regulation of RAS by GAPs; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of ornithine decarboxylase (ODC); Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF(Skp2)-mediated degradation of p27/p21; Degradation of beta-catenin by the destruction complex; Autodegradation of the E3 ubiquitin ligase COP1; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of DVL; Hedgehog ligand biogenesis; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; GLI3 is processed to GLI3R by the proteasome; NIK-->noncanonical NF-kB signaling; Orc1 removal from chromatin; G2/M Checkpoints; Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; KEAP1-NFE2L2 pathway; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Proteasome assembly; Degradation of CRY and PER proteins	0.352170304218592	0.611696578028305	0.289331214816837	0.491148955876067	0.968175059132934	0.988818336174862	0.946018783860301	0.953305976192702	6898.14589556078		6270.01400923413	153396.702725889	164536.380863759	147500.24794822	17241.4415491727	20840.5950243591	63055.7244355571	350895.573359141	291768.626119094	167900.318034882	117868.660238525	56916.1488734056	85276.5651790465
P62880	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [OS=Mus musculus]	30.458	23	7	72	3	340	37.3	signal transduction;other biological processes	plasma membrane;other membranes;other cell component	other molecular function	14693	ENSMUSG00000029713	Gnb2	mmu:14693; P11016; P54312; P62880	Chemokine signaling pathway; G protein signaling pathways; Focal adhesion: PI3K-Akt-mTOR signaling pathway; Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells	Ca2+ pathway; Extra-nuclear estrogen signaling; G alpha (q) signalling events; G alpha (12/13) signalling events; G beta:gamma signalling through PLC beta; Presynaptic function of Kainate receptors; G alpha (i) signalling events; ADP signalling through P2Y purinoceptor 12; Adrenaline,noradrenaline inhibits insulin secretion; G alpha (s) signalling events; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Vasopressin regulates renal water homeostasis via Aquaporins; Thromboxane signalling through TP receptor; High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells; Thrombin signalling through proteinase activated receptors (PARs); G-protein activation; Glucagon-type ligand receptors; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; G alpha (z) signalling events; G beta:gamma signalling through CDC42; Activation of G protein gated Potassium channels; Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits; GPER1 signaling; ADP signalling through P2Y purinoceptor 1; G beta:gamma signalling through PI3Kgamma; Prostacyclin signalling through prostacyclin receptor; G beta:gamma signalling through BTK	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.647154303172883	0.696358249006924	0.553867798711709	0.849720620922415				373142.476592496	415935.809223032	563383.155542397	334203.349788062	275117.637458447	326764.592341721	1976695.06056651	1639286.94210331	1348659.74152942	643173.389556346	584228.658308512	941758.230184176
Cont_Q9TT36	Thyroxine-binding globulin OS=Bos taurus OX=9913 GN=SERPINA7 PE=2 SV=1	20.107	23	8	83	8	411	46		non-structural extracellular	enzyme regulator activity	282518		SERPINA7	bta:282518; Q9TT36			0.680512751151318	0.464669703296566	0.545178983856956	0.474382102623887	0.731850662833984	0.864215513767001	0.937453377971347	0.396893134821035	1616548.31101405	1108861.63401495	883747.651998056	908592.770798377	1320774.38950916	1450279.42886763	1009991.93391258	867099.044238206	1079185.56638034	1180162.07905869	1302727.77338899	647127.390367828	823922.859241308	824195.298536857	1632057.98876701
Cont_A0A3Q1M3L6	Uncharacterized protein OS=Bos taurus OX=9913 PE=1 SV=1	27.155	23	5	61	5	367	40.5										0.470090980642528	0.559299438563734	0.548308513139987	0.239347562647817	0.944154202827561	0.15729598575093	0.362379187194941	0.483015668880262	1813983.88881127	1439650.81951	526629.233401614	822885.572979104	1168488.96921548	1068581.10548652	1547950.34707483	1183465.54029919	983263.8898759	1435668.52536931	1191546.58038583	1314640.75960898	497492.85287102	450613.154069584	1152586.56554244
P70168	Importin subunit beta-1 [OS=Mus musculus]	76.123	22	17	129	17	876	97.1	cell cycle OR cell proliferation;cell organization and biogenesis;transport	other membranes;cytosol;ER/Golgi;nucleus;other cell component	other molecular function	16211	ENSMUSG00000001440	Kpnb1	mmu:16211; P70168; Q62117; Q6GTI5	Mechanisms associated with pluripotency	Neutrophil degranulation; Interferon alpha/beta signaling; Initiation of Nuclear Envelope (NE) Reformation; Assembly of the ORC complex at the origin of replication; Apoptosis induced DNA fragmentation; Regulation of cholesterol biosynthesis by SREBP (SREBF)	1.65082956259427E-17	0.00711088397230487	1.50457038391225E-17	0.114337355530219	0.922179983282929	0.941920360687835	0.964607496373235	0.809503222445875	5499.98008735053			784139.186389022	989481.472390897	600886.279758514	259618.893370928	348042.378810896	457351.48860576	2597434.46785177	1766140.82585067	1458085.26320977	546636.723682928	452500.56707148	665505.80313989
Q6P8I4	PEST proteolytic signal-containing nuclear protein [OS=Mus musculus]	11.579	22	3	15	3	178	19	protein metabolism;other metabolic processes	nucleus		76302	ENSMUSG00000071533	Pcnp	mmu:76302; Q6P8I4			1.65082956259427E-17		1.50457038391225E-17	1.70336894001643E-17	0.774040375289649	5.07936507936508E-17	5.0092807424594E-17	0.35261240745661				88230.7784178707	49640.7696038666	21521.4398568097				294170.317097785	219144.707522888	198443.569479038			18745.3345186852
P58044	Isopentenyl-diphosphate Delta-isomerase 1 [OS=Mus musculus]	8.428	22	4	10	4	227	26.3	other metabolic processes;other biological processes	other cytoplasmic organelle	other molecular function	319554	ENSMUSG00000058258	Idi1	mmu:319554; P58044; Q4FJU2	Cholesterol biosynthesis; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Exercise-induced circadian regulation	Cholesterol biosynthesis	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.122661702934606	0.916816605589483	0.19809270122422	0.988640647886026				172387.971369398	190394.745902056	86699.5626149972	46646.0080194075		61622.4000306695	44534.9918142174	41965.0716078071		21006.1255379141
Cont_Q3SZV7	Hemopexin OS=Bos taurus OX=9913 GN=HPX PE=2 SV=1	48.256	22	9	179	9	459	52.2	other metabolic processes;transport;other biological processes	non-structural extracellular	transporter activity;other molecular function	534509		HPX	bta:534509; Q3SZV7			0.591873375996003	0.964209443670126	0.492371702098489	0.667021684123027	0.792564971776066	0.114920709444701	0.785941568427411	0.0343409541468602	6428086.39400227	5730902.63035767	2774130.83679403	5380029.63743518	5923520.96758849	6373048.53488891	9435433.87169189	7776773.10871298	8564366.7210049	5121167.86856824	5637566.69629445	3804410.52496499	4574131.71646301	5732151.3807355	8113008.99948645
P46935	E3 ubiquitin-protein ligase NEDD4 [OS=Mus musculus]	62.596	22	16	78	16	887	102.6	cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes	plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component	signal transduction activity or receptor binding;other molecular function	17999	ENSMUSG00000032216	Nedd4	mmu:17999; O08758; P46935; Q3UZI2; Q8BGB3	Proteasome degradation	Antigen processing: Ubiquitination & Proteasome degradation; Regulation of PTEN stability and activity; Regulation of PTEN localization; ISG15 antiviral mechanism; Downregulation of ERBB4 signaling	0.641800617852975	0.303813049105831	0.421079413960784	0.413550887335427	0.602340491101035	0.930664206870897	0.977491813528386	0.493742872730699	3446660.20090537	3343944.59441507	3126868.97237926	3349040.14452299	3786490.80414191	4351304.652558	1874838.451564	2072078.03382529	3705888.57191791	3281141.63080512	3870536.12273843	2931064.84227065	1505567.1961079	2006296.34187356	4994036.44080075
P62852	Small ribosomal subunit protein eS25 [OS=Mus musculus]	8.722	22	3	45	3	125	13.7	protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes	cytosol;translational apparatus;nucleus;other cell component	other molecular function	75617	ENSMUSG00000009927	Rps25	mmu:75617; P25111; P62852	Cytoplasmic ribosomal proteins	SRP-dependent cotranslational protein targeting to membrane; L13a-mediated translational silencing of Ceruloplasmin expression; Major pathway of rRNA processing in the nucleolus and cytosol; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.831346099319977	0.783910800136359	0.908923163051514	0.960067393782086				372075.884891366	564566.323503661	294678.239009688	261192.082776052	282626.938538071	409047.161828662	1129804.86350458	1035554.28901839	813029.473234681	348828.517742643	370674.488094527	667683.789605553
Q9CVB6	Actin-related protein 2/3 complex subunit 2 [OS=Mus musculus]	18.872	22	7	56	7	300	34.3	cell organization and biogenesis;other biological processes	plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component	cytoskeletal activity	76709	ENSMUSG00000006304	Arpc2	mmu:76709; Q3U870; Q9CVB6	Comprehensive IL-17A signaling	Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; EPHB-mediated forward signaling; RHO GTPases Activate WASPs and WAVEs	0.751668542011388	0.939028329988127	0.999577296233586	0.887279041944908	0.998719389228602	0.876229971351488	0.815681633549897	0.976852696203657	48123.0385048734	49541.4222244436	43547.0728982973	734909.007309933	866739.708056784	554312.622407569	275300.963429159	246146.174283854	444761.519200407	1098138.19907894	1200307.62229726	963643.710506191	404895.753887865	352899.80706475	721237.71409981
Q3U0V1	Far upstream element-binding protein 2 [OS=Mus musculus]	60.307	22	11	52	10	748	76.7	RNA metabolism OR transcription;other metabolic processes;transport;other biological processes	cytosol;nucleus;other cell component	nucleic acid binding activity	16549	ENSMUSG00000007670	Khsrp	E9QKH3; mmu:16549; Q2VPQ6; Q3U0V1; Q6P2L2		KSRP (KHSRP) binds and destabilizes mRNA	0.921301291486941	1.8644578313253E-17	0.99300501743318	0.555399849801059	0.996781804665575	5.07936507936508E-17	5.0092807424594E-17	0.739241092013169	176409.731668119	2350.91836869678	113174.267295306	481137.107614274	350558.878816864	556088.656522804				1185808.85337	911117.982153751	754244.264358107	203114.490936372	19608.9370848044	171435.70904447
Q8JZK9	Hydroxymethylglutaryl-CoA synthase, cytoplasmic [OS=Mus musculus]	35.1	22	10	23	10	520	57.5	other metabolic processes	other cell component	other molecular function	208715	ENSMUSG00000093930	Hmgcs1	mmu:208715; Q3UXI4; Q8JZK9	Cholesterol biosynthesis; Endochondral ossification; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways	Cholesterol biosynthesis	0.945514723098446		0.296183705219684		0.528654273241886	0.97873503980026	0.883039867519245	0.880760468933162	12178.4149452567	35261.5988006007		101123.693274138	200218.346217201	86734.4161990809	22784.837486532	18551.6162785267	51792.5149205691	95075.042503125	26482.9958588885	103133.670852327	80314.0801268393		8977.66157954543
P14115	Large ribosomal subunit protein uL15 [OS=Mus musculus]	12.599	22	3	24	3	148	16.6	protein metabolism;other metabolic processes	cytosol;ER/Golgi;translational apparatus;other cell component	other molecular function	26451	ENSMUSG00000046364	Rpl27a	mmu:26451; P14115; Q9CQ16; Q9R1X6	Cytoplasmic ribosomal proteins	L13a-mediated translational silencing of Ceruloplasmin expression; SRP-dependent cotranslational protein targeting to membrane; Major pathway of rRNA processing in the nucleolus and cytosol; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Protein hydroxylation	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.813125878382186	0.925871264502428	0.695927216301667	0.819844267712751				260690.50066514	445849.455606733	317850.037591653	131472.622809344	170691.556989268	225635.601296196	882824.825960765	881048.640798219	693448.09930195	199609.6543506	196363.11651863	496357.334341963
Q62188	Dihydropyrimidinase-related protein 3 [OS=Mus musculus]	32.74	22	10	55	8	570	61.9	cell organization and biogenesis;stress response;developmental processes;other biological processes	non-structural extracellular;cytosol;cytoskeleton;ER/Golgi;other cell component	cytoskeletal activity;other molecular function	22240	ENSMUSG00000024501	Dpysl3	mmu:22240; Q62188		CRMPs in Sema3A signaling	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.946568086066385	0.916816605589483	0.531887615721023	0.940009206000478				198064.53656182	245870.890593217	110736.484081291	28145.6043838078	68617.2515483605	113592.931177909	506714.018974664	514502.268239408	259818.337491567			23858.4433857579
Cont_P08727	Keratin, type I cytoskeletal 19 OS=Homo sapiens OX=9606 GN=KRT19 PE=1 SV=4	38.954	22	11	283	1	400	44.1	cell organization and biogenesis;developmental processes;signal transduction;other biological processes	plasma membrane;other membranes;cytosol;cytoskeleton;other cell component	cytoskeletal activity;other molecular function	3880	ENSG00000171345	KRT19	B2R874; hsa:3880; P08727; Q5XG83; Q6NW33; Q7L5M9; Q96A53; Q96FV1; Q9BYF9; Q9P1Y4	Galanin receptor pathway	Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin; Developmental Lineage of Pancreatic Ductal Cells	0.910933522912184	0.261594330737821	0.597357815872892	0.843924307891518	0.445660587675606	0.354582899583246	0.0208387060045054	0.00190391586917159	104952.705561187	65469.1175573445	216925.42003783	122030.011875444	184717.390641416	255933.424777002	49217.3859834231	56377.5268107145	64489.4081748903	133295.478230346	152409.789256012	79494.9876777713	315140.001439473	334237.402240918	213219.651402791
Q9Z0N1	Eukaryotic translation initiation factor 2 subunit 3, X-linked [OS=Mus musculus]	29.925	22	9	52	9	472	51	protein metabolism;other metabolic processes	cytosol;other cell component	nucleic acid binding activity;other molecular function	26905	ENSMUSG00000035150	Eif2s3x	mmu:26905; Q9Z0N1	Translation factors	L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Recycling of eIF2:GDP; ABC-family proteins mediated transport; Cellular response to mitochondrial stress; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; PERK regulates gene expression	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.974827674952665	0.864215513767001	0.889188944286717	0.999950801685853				382134.603667223	417269.53444405	140227.016764144	157239.637906938	150570.586369217	338734.207245874	660247.298817687	591605.192272668	451169.319816099	239752.350077458	58423.5606295693	228901.466956134
Q9D1R9	Large ribosomal subunit protein eL34 [OS=Mus musculus]	5.307	22	3	15	3	117	13.3	protein metabolism;other metabolic processes	cytosol;ER/Golgi;translational apparatus;nucleus;other cell component	other molecular function	68436	ENSMUSG00000062006	Rpl34	mmu:619547; mmu:68436; Q497V4; Q9D1R9	Cytoplasmic ribosomal proteins	L13a-mediated translational silencing of Ceruloplasmin expression; SRP-dependent cotranslational protein targeting to membrane; Major pathway of rRNA processing in the nucleolus and cytosol; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	0.283730749038319	0.0776929895182709	1.50457038391225E-17	0.131791766005222	0.777389280685064	0.321277110136796	0.899694965805823	0.813866215697493			4132.8897547964	30053.7958888767	52721.8464005905	20796.9369080098	47591.5259407107	37729.9102406279	60887.2648814086	171999.417151909	122584.620639954	107034.79195499	45540.9793650301	53460.9410464777	120177.065387494
O88487	Cytoplasmic dynein 1 intermediate chain 2 [OS=Mus musculus]	39.343	22	9	51	9	612	68.4	other biological processes	cytoskeleton;other cell component		13427	ENSMUSG00000027012	Dync1i2	mmu:13427; O88487; Q3TGH7		COPI-mediated anterograde transport; Separation of Sister Chromatids; MHC class II antigen presentation; Anchoring of the basal body to the plasma membrane; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Resolution of Sister Chromatid Cohesion; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; RHO GTPases Activate Formins; AURKA Activation by TPX2; EML4 and NUDC in mitotic spindle formation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-independent Golgi-to-ER retrograde traffic; Aggrephagy	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.955415831169955	0.983440558239231	0.977853974998917	0.990873516209569				86251.8063737843	182823.139283392	151360.497750351		32962.0282672743	64034.7323464086	716607.381663451	519238.633515568	470085.300608536	24076.3419811217	44580.3466467261	42746.6761370549
Q99KQ4	Nicotinamide phosphoribosyltransferase [OS=Mus musculus]	30.525	22	9	49	9	491	55.4	other metabolic processes;stress response;signal transduction;other biological processes	non-structural extracellular;cytosol;mitochondrion;nucleus;other cell component	signal transduction activity or receptor binding;other molecular function	59027	ENSMUSG00000020572	Nampt	mmu:59027; Q8C3B5; Q99KQ4; Q9JKM0	Adipogenesis genes	Nicotinate metabolism	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.371664928477551	0.988373509764139	0.664971370235365	0.659567728531141				165169.773352199	173553.66209573	31506.7019533263	40345.1150945205	15471.8116982504	48293.9303575319	1119664.504459	883313.632871694	691075.483596806	241459.127299466	87047.2437142529	308940.920112802
Q9Z1N5	Spliceosome RNA helicase Ddx39b [OS=Mus musculus]	19.947	22	7	45	3	428	49	cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport	nucleus;other cell component	nucleic acid binding activity;other molecular function	53817	ENSMUSG00000019432	Ddx39b	mmu:53817; Q8HW97; Q9Z1N5	miRNAs and TFs in iPS Cell Generation; mRNA processing	mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; RHOBTB2 GTPase cycle	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.42706865755464	0.900334730044572	0.883039867519245	0.657199102356574				355974.710252062	446306.421922803	241904.177784886	205295.530012507	211074.056422468	331206.56336076	1478693.10956592	1275961.13711007	1083705.62590219	362462.892042131	162361.102786189	485829.060695893
Q9D8E6	Large ribosomal subunit protein uL4 [OS=Mus musculus]	31.608	22	9	80	9	419	47.1	protein metabolism;other metabolic processes	cytosol;ER/Golgi;translational apparatus;nucleus;other cell component	other molecular function	67891	ENSMUSG00000032399	Rpl4	mmu:67891; Q9CY08; Q9D8E6	Cytoplasmic ribosomal proteins	L13a-mediated translational silencing of Ceruloplasmin expression; SRP-dependent cotranslational protein targeting to membrane; Major pathway of rRNA processing in the nucleolus and cytosol; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.889445903483421	0.97873503980026	0.977491813528386	0.901489646134689				716175.218113865	908858.197556988	558220.362382764	406597.501277142	473007.187794949	594342.513768406	1832732.01550452	2052503.19109206	1439430.20903736	545437.151669189	429049.926017423	839159.533702747
P18242	Cathepsin D [OS=Mus musculus]	36.46	22	7	79	7	410	44.9	cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes	non-structural extracellular;other membranes;cytosol;other cytoplasmic organelle;other cell component	other molecular function	13033	ENSMUSG00000007891	Ctsd	mmu:13033; P18242		Neutrophil degranulation; MHC class II antigen presentation; Insulin receptor recycling; Collagen degradation; Metabolism of Angiotensinogen to Angiotensins	0.934300915833922	0.73072258897653	0.992435928992899	0.837987420206458	0.938859506774495	0.947247164456515	0.915694695059804	0.338369426911459	143460.916800614	217921.925818947	118462.042137559	1197861.18936406	1254225.04841219	822058.546948121	651379.562069283	647290.113690249	859757.258828467	1241930.1564623	1457196.60745491	919007.122286989	839064.454674018	484876.33370398	1369783.98776697
Q3U1J4	DNA damage-binding protein 1 [OS=Mus musculus]	60.964	22	23	131	23	1140	126.8	cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes	nucleus;other cell component	nucleic acid binding activity;other molecular function	13194	ENSMUSG00000024740	Ddb1	mmu:13194; Q3U1J4; Q3U4D0; Q3U8G3; Q3UJC4; Q99LV3; Q9QYK0; Q9WV39	Mechanisms associated with pluripotency	Neddylation; DNA Damage Recognition in GG-NER; Formation of TC-NER Pre-Incision Complex; Recognition of DNA damage by PCNA-containing replication complex; Formation of Incision Complex in GG-NER; Dual Incision in GG-NER; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER	0.941324060398065	0.996272934019876	0.886831819172333	0.923207315543201	0.944154202827561	0.997472728448278	0.937453377971347	0.938282411159324	95231.3938193339	55087.2754444704	67704.2931088638	1498655.68360977	1428494.95336967	1689617.63530364	649569.720266679	510355.762787782	1038942.97344328	2047503.88557596	2041749.29253775	1256757.30006009	453359.402574858	465164.544158102	923338.289811785
P62754	Small ribosomal subunit protein eS6 [OS=Mus musculus]	25.714	22	5	54	5	249	28.7	cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes	cytosol;translational apparatus;nucleus;other cell component	other molecular function	20104	ENSMUSG00000028495	Rps6	mmu:20104; P08227; P10660; P62754	Cytoplasmic ribosomal proteins; Focal adhesion: PI3K-Akt-mTOR signaling pathway; mRNA processing	L13a-mediated translational silencing of Ceruloplasmin expression; SRP-dependent cotranslational protein targeting to membrane; Major pathway of rRNA processing in the nucleolus and cytosol; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Protein hydroxylation; mTORC1-mediated signalling; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition	0.143307996562821	0.0650444265432465	0.320525504300916	0.102269914384148	0.800116740445568	0.696358249006924	0.933437821008547	0.923354913468945	155576.540757843	78694.6228210378	176975.847894677	635320.30082641	607020.812313922	351008.886686619	364179.326464056	441622.472484916	696542.399155585	1907630.88627986	1905808.87604059	1526808.38656829	694785.692664303	464073.241827439	845515.17812741
Q8BVI4	Dihydropteridine reductase [OS=Mus musculus]	15.67	22	3	13	3	241	25.6	other metabolic processes		other molecular function	110391	ENSMUSG00000015806	Qdpr	mmu:110391; Q3TT09; Q8BVI4; Q9D0K4		Phenylalanine metabolism			1.50457038391225E-17		6.99442896935933E-17			5.71658986175115E-17										81230.0957430719	64745.5546954187	66337.1132451597
Q93092	Transaldolase [OS=Mus musculus]	25.109	22	7	50	7	337	37.4	other metabolic processes	cytosol;nucleus;other cell component	other molecular function	21351	ENSMUSG00000025503	Taldo1	mmu:21351; P70358; P70703; Q52KM4; Q93092	Pentose phosphate pathway	Insulin effects increased synthesis of Xylulose-5-Phosphate; Pentose phosphate pathway	0.739221754220425	0.577662571906184	0.597048066168022	0.992430739604997	0.944154202827561	0.98558531112136	0.878843662685239	0.930153213658764	68096.2669558044	68855.4985826516	51926.1867916683	398082.81623006	367001.815665768	371791.662799669	203355.11277732	175102.305952347	416187.389766901	1340428.00335573	1160978.10630252	738792.100639569	211716.741029561	139594.515474253	542087.231325255
Q8BH97	Reticulocalbin-3 [OS=Mus musculus]	32.559	22	6	75	6	328	38	protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes	ER/Golgi	other molecular function	52377	ENSMUSG00000019539	Rcn3	mmu:52377; Q58E50; Q8BH97; Q8R137; Q99K35; Q9CTD4			1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.990459928977729	0.834630661117411	0.651150875519071	0.605657151543387				474605.398086054	303224.630085505	571988.791421671	296079.439776446	171695.325484416	229688.631624901	950263.880747745	914848.489577244	750119.248783823	394144.879628673	361221.101954515	663580.453734955
P56480	ATP synthase subunit beta, mitochondrial [OS=Mus musculus]	38.401	22	9	71	9	529	56.3	other metabolic processes;transport;developmental processes;other biological processes	plasma membrane;other membranes;mitochondrion;other cell component	signal transduction activity or receptor binding;transporter activity;other molecular function	11947	ENSMUSG00000025393	Atp5f1b	mmu:11947; P56480; Q0QEP4; Q3TFD7; Q3TIP9; Q3TK44; Q3TWD5; Q3TX28; Q3U6U4; Q3U774; Q3UB69; Q3UF69; Q8CI65; Q8VEJ5; Q9CTI7; Q9CWX7	Oxidative phosphorylation; Electron transport chain	Mitochondrial protein degradation; Mitochondrial protein import; Formation of ATP by chemiosmotic coupling; Cristae formation	0.475059564825458	0.519759833717771	1.50457038391225E-17	0.174727361068279	0.575074558202333	0.995498076353197	0.12549512724184	0.692549263093059	11158.3265258087	11283.2415372615	12491.8678804999	262687.317597173	398339.638805996	208003.562137919	131271.008228092	159705.988449372	159502.958522786	1116505.13977146	1503738.18145861	977353.175002199	858331.148487486	635625.677511896	830556.822965311
P41105	Large ribosomal subunit protein eL28 [OS=Mus musculus]	8.642	22	3	20	3	137	15.7	protein metabolism;other metabolic processes	cytosol;translational apparatus;other cell component	other molecular function	19943	ENSMUSG00000030432	Rpl28	mmu:19943; P41105	Cytoplasmic ribosomal proteins	L13a-mediated translational silencing of Ceruloplasmin expression; SRP-dependent cotranslational protein targeting to membrane; Major pathway of rRNA processing in the nucleolus and cytosol; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.577989402009442	0.373292142753803	0.755800677712522	0.508243918164012				93792.4543748323	146186.074295859	111666.724863925	152754.728607223	120981.487783644	158381.333077037	451336.854695387	395301.225836175	283933.671133745	253974.629017129	179898.974449137	256787.572624948
P62627	Dynein light chain roadblock-type 1 [OS=Mus musculus]	5.253	22	2	14	2	96	11	other biological processes	cytoskeleton;other cell component	other molecular function	67068	ENSMUSG00000047459	Dynlrb1	A2AVR8; mmu:67068; O88567; P62627; Q4FZJ8; Q9D812		Intraflagellar transport	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.854305439376382	0.686266636325501	0.362379187194941	0.00155992108682643				65052.480549247			25623.5508557496	24075.9452080001	41176.1826735585	250867.537491124	210333.055335032	240440.343564253	12285.7433488118
P63158	High mobility group protein B1 [OS=Mus musculus]	19.302	22	4	41	4	215	24.9	cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes	non-structural extracellular;plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component	signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function	15289	ENSMUSG00000066551	Hmgb1	mmu:15289; P07155; P27109; P27428; P63158	Comprehensive IL-17A signaling	Neutrophil degranulation; Advanced glycosylation endproduct receptor signaling; Regulation of TLR by endogenous ligand; Pyroptosis; Apoptosis induced DNA fragmentation; TAK1-dependent IKK and NF-kappa-B activation ; TRAF6 mediated NF-kB activation	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.259548977998244	0.848119069115724	0.967312324241493	0.278473181741113				850035.421731218	923302.181331714	694100.00843335	481119.433560821	473314.810210566	660152.864500341	3958384.29198737	3954672.29475616	2407050.43306332	573391.00176031	332831.972653012	952199.149724836
Q9D0J8	Parathymosin [OS=Mus musculus]	10.198	22	2	34	2	101	11.4	other biological processes			69202	ENSMUSG00000030122	Ptms	mmu:69202; Q9D0J8			1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.910377938946326	0.941920360687835	0.977491813528386	0.732919217838237	12935.8329725158			1000791.14656909	1054015.63584583	1249641.72700844	660628.2094459	476789.858216505	793416.263382012	2880714.97018202	2765846.15463909	1958786.19548408	671747.652803148	764800.004837436	937980.085320431
P56380	Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [OS=Mus musculus]	14.608	22	2	6	2	147	17	other biological processes		other molecular function	66401	ENSMUSG00000028443	Nudt2	mmu:66401; P56380; Q9D2U6; Q9D6V2	Purine metabolism	Detoxification of Reactive Oxygen Species	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17		0.923904446717656	0.252062076425306	5.0092807424594E-17	5.71658986175115E-17				38278.9707821296	30446.1440308216				47924.704502994			70745.6043077507
P62960	Y-box-binding protein 1 [OS=Mus musculus]	20.754	22	5	34	2	322	35.7	RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes	non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component	nucleic acid binding activity;other molecular function	22608	ENSMUSG00000028639	Ybx1	mmu:22608; P22568; P27817; P43482; P62960	SIDS susceptibility pathways; Mecp2 and associated Rett syndrome; mRNA processing; IL-2 signaling pathway	mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA; mRNA Splicing - Minor Pathway; Interferon gamma signaling; Noncanonical activation of NOTCH3				1.70336894001643E-17			5.0092807424594E-17	5.71658986175115E-17													32843.8770567939	19098.3551311167
Q69ZN7	Myoferlin [OS=Mus musculus]	112.647	22	36	227	36	2048	233.2	cell organization and biogenesis;other metabolic processes;stress response;other biological processes	plasma membrane;other membranes;nucleus	other molecular function	226101	ENSMUSG00000048612	Myof	mmu:226101; Q69ZN7; Q7TMG0; Q80V33; Q8BU64; Q8BU70; Q8BUC1; Q8BVY6; Q8C0D1; Q8R3B4			0.73657372909066	0.964709887217926	0.888974672311279	0.930955411749965	0.816275429153737	0.877818946381645	0.609903091678244	0.975029032316037	86000.3771233404	87234.2597428081	50456.7230101595	780930.944201502	985609.680593147	968573.73043394	296294.389327177	289800.794039455	380995.072506467	3324626.35891918	3238695.05806667	2634093.62813707	1025817.2029614	993761.586050851	1295229.11918404
Q9Z2X1	Heterogeneous nuclear ribonucleoprotein F [OS=Mus musculus]	21.173	22	6	31	4	415	45.7	RNA metabolism OR transcription;other metabolic processes;other biological processes	cytosol;nucleus;other cell component	nucleic acid binding activity	98758	ENSMUSG00000042079	Hnrnpf	mmu:98758; Q5FWK2; Q8BVU8; Q8K2U9; Q8R0E7; Q9Z2X1	Mecp2 and associated Rett syndrome; mRNA processing	mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA	0.591750274432579	0.951811374914273	0.285121389305776	0.743086654540196	0.976873891151678	0.117620591805243	0.850760367544917	0.500458908493238	558826.088073666	690725.234609944	379813.965616835	595191.975072797	576997.868085804	676798.335607384	869852.618027306	1126853.46712048	567903.850674315	846334.757117598	825005.963341683	710303.073153196	710075.768012121	940729.080288333	646234.155057626

Peptides	2
U peptides	1
Coverage >=	0.04

100

Accession	Description	Sum PEP Score	Coverage [%]	# Peptides	# PSMs	# Unique Peptides	# AAs	MW [kDa]	Biological Process	Cellular Component	Molecular Function	Entrez Gene ID	Ensembl Gene ID	Gene Symbol	Gene ID	WikiPathways	Reactome Pathways	Abundance Ratio: (LQ_16h) / FM	Abundance Ratio: (LQ_6h) / FM	Abundance Ratio: (SQ_16h) / FM	Abundance Ratio: (SQ_6h) / FM	Abundance Ratio: (SQ_16h) / (LQ_16h)	Abundance Ratio: (LQ_16h) / (LQ_6h)	Abundance Ratio: (SQ_6h) / (LQ_6h)	Abundance Ratio: (SQ_16h) / (SQ_6h)	Abundance Ratio Adj. P-Value: (LQ_16h) / FM	Abundance Ratio Adj. P-Value: (LQ_6h) / FM	Abundance Ratio Adj. P-Value: (SQ_16h) / FM	Abundance Ratio Adj. P-Value: (SQ_6h) / FM	Abundance Ratio Adj. P-Value: (SQ_16h) / (LQ_16h)	Abundance Ratio Adj. P-Value: (LQ_16h) / (LQ_6h)	Abundance Ratio Adj. P-Value: (SQ_6h) / (LQ_6h)	Abundance Ratio Adj. P-Value: (SQ_16h) / (SQ_6h)	Abundances (Normalized): F1: Sample, FM	Abundances (Normalized): F2: Sample, FM	Abundances (Normalized): F3: Sample, FM	Abundances (Normalized): F8: Sample, LQ_16h	Abundances (Normalized): F9: Sample, LQ_16h	Abundances (Normalized): F10: Sample, LQ_16h	Abundances (Normalized): F4: Sample, LQ_6h	Abundances (Normalized): F5: Sample, LQ_6h	Abundances (Normalized): F6: Sample, LQ_6h	Abundances (Normalized): F17: Sample, SQ_16h	Abundances (Normalized): F18: Sample, SQ_16h	Abundances (Normalized): F20: Sample, SQ_16h	Abundances (Normalized): F14: Sample, SQ_6h	Abundances (Normalized): F15: Sample, SQ_6h	Abundances (Normalized): F16: Sample, SQ_6h
P11276	Fibronectin [OS=Mus musculus]	867.353	58	95	2246	59	2477	272.4	cell adhesion;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes	non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi	signal transduction activity or receptor binding;enzyme regulator activity;other molecular function	14268	ENSMUSG00000026193	Fn1	G5E8B8; mmu:14268; P11276; Q61567; Q61568; Q61569; Q64233; Q80UI4	Focal adhesion: PI3K-Akt-mTOR signaling pathway; Inflammatory response pathway; Regulation of actin cytoskeleton; Comprehensive IL-17A signaling; Focal adhesion	ECM proteoglycans; Platelet degranulation ; Cell surface interactions at the vascular wall; Syndecan interactions; MAP2K and MAPK activation; Integrin cell surface interactions; Molecules associated with elastic fibres; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Fibronectin matrix formation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; Degradation of the extracellular matrix; Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells; MET activates PTK2 signaling; GPER1 signaling	16.191	18.678	20	12.982	1.439	0.984	0.516	2.74	0.0844744457809114	0.00584906503121538	1.50457038391225E-17	0.156115961659409	0.974036928885484	0.564710097967506	0.435823028559966	0.896613838854506	3.10111960161575E7	2.79853612635427E7	2.39278028537136E7	2.27076161669542E8	2.29530848002383E8	1.81481696567249E8	2.13523563015262E8	1.92386583493888E8	2.00792310651879E8	3.0604731494329E8	2.72875123758133E8	2.45952285820886E8	1.1928889459527E8	1.00071254189999E8	1.59531432686856E8
P11087	Collagen alpha-1(I) chain [OS=Mus musculus]	797.017	79	75	1933	35	1453	137.9	cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes	non-structural extracellular;extracellular matrix;other cell component	extracellular structural activity;other molecular function	12842	ENSMUSG00000001506	Col1a1	mmu:12842; P11087; Q53WT0; Q60635; Q61367; Q61427; Q63919; Q6PCL3; Q810J9	Osteoblast signaling; Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Comprehensive IL-17A signaling; Focal adhesion	Cell surface interactions at the vascular wall; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ECM proteoglycans; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; GPVI-mediated activation cascade; GP1b-IX-V activation signalling; Platelet Adhesion to exposed collagen; Platelet Aggregation (Plug Formation); MET activates PTK2 signaling	20	20	20	20	0.142	3.208	0.295	1.664	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	1.58880673198775E-4	0.381922652011049	0.0629214061377862	0.655833157547641	703080.609341466	1047026.5902454	567207.050774397	6.12803341835757E8	6.28616080368892E8	5.37143706349406E8	2.20652487774689E8	1.86114398805651E8	2.17194307013081E8	9.46570689754052E7	9.72166914362706E7	6.09758172025116E7	6.01286898886734E7	4.84358218594371E7	7.06441702532683E7
Q01149	Collagen alpha-2(I) chain [OS=Mus musculus]	773.662	80	66	1731	51	1372	129.5	cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes	non-structural extracellular;extracellular matrix;other cell component	extracellular structural activity;other molecular function	12843	ENSMUSG00000029661	Col1a2	mmu:12843; Q01149; Q8CGA5	Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Focal adhesion	Crosslinking of collagen fibrils; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; ECM proteoglycans; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; GPVI-mediated activation cascade; GP1b-IX-V activation signalling; Platelet Adhesion to exposed collagen; Platelet Aggregation (Plug Formation); MET activates PTK2 signaling	20	20	20	20	0.279	2.097	0.261	2.151	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.0150838661305169	0.862063111456553	0.0347692006632991	0.926292871155025	217896.573253055	102775.453905646	225868.955510701	3.82374533805921E8	3.80614155239716E8	2.79801552870279E8	1.73556920519588E8	1.55763113653521E8	1.89931753802048E8	1.03217412397752E8	1.04517075360638E8	6.33578194684048E7	4.96147162399626E7	2.65479311979207E7	5.19818116295111E7
P08121	Collagen alpha-1(III) chain [OS=Mus musculus]	695.631	63	61	1789	51	1464	138.9	cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes	extracellular matrix;other cell component	signal transduction activity or receptor binding;extracellular structural activity;other molecular function	12825	ENSMUSG00000026043	Col3a1	mmu:12825; P08121; Q61429; Q9CRN7	Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Focal adhesion	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ECM proteoglycans; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; MET activates PTK2 signaling	20	20	20	20	0.247	5.055	0.497	2.464	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.00738207855214502	0.0413994480640273	0.394949139624895	0.976852696203657	619884.023482232	468692.52789102	275667.802679115	2.79020579584843E8	2.94236692581693E8	2.78582579285209E8	6.51340156000414E7	5.70632610319163E7	6.62894421161806E7	7.54516142044654E7	7.68700494785543E7	4.61499837269909E7	3.06665885804687E7	2.39448217703501E7	3.64849658219652E7
Q9QXS1	Plectin [OS=Mus musculus]	659.702	46	182	1705	180	4691	533.9	cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes	plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component	cytoskeletal activity;other molecular function	18810	ENSMUSG00000022565	Plec	E9QN87; mmu:18810; Q6S384; Q6S389; Q6S394; Q9CS65; Q9QUT2; Q9QXQ8; Q9QXQ9; Q9QXR0; Q9QXR1; Q9QXR2; Q9QXR3; Q9QXR4; Q9QXR5; Q9QXR6; Q9QXR7; Q9QXR8; Q9QXR9; Q9QXS0; Q9QXS1; Q9QXS2; Q9QXS3	Alpha 6 beta 4 integrin signaling pathway; EGFR1 signaling pathway	Type I hemidesmosome assembly; Caspase-mediated cleavage of cytoskeletal proteins	5.459	2.593	9.846	4.989	2.383	2.864	1.839	3.715	0.481729871164266	0.714932595871944	0.336550483871782	0.572524806937582	0.850917681937748	0.532399788858771	0.702330308974487	0.520376293994664	307407.817065559	282192.990008148	340166.735457239	1.95783440606639E7	1.89230076526173E7	1.15266683074569E7	3962115.44279651	3474477.32513512	6361226.57462356	5.1842207663806E7	4.48709077668655E7	3.18339270889303E7	1.10137014373925E7	7604177.6415354	1.18325057871337E7
P08122	Collagen alpha-2(IV) chain [OS=Mus musculus]	526.992	64	69	1077	69	1707	167.2	RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes	non-structural extracellular;extracellular matrix	extracellular structural activity	12827	ENSMUSG00000031503	Col4a2	mmu:12827; P08122; Q3B7C2; Q3TPV9; Q61375; Q66JS5; Q6RCT6; Q6RCT7; Q6U9X1; Q8BPI9; Q8BPK3; Q91VI3	Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Focal adhesion	Laminin interactions; Signaling by PDGF; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions	7.029	2.876	10.91	3.309	1.603	3.934	1.208	3.852	0.352816378116182	0.64759425713406	0.293387877727491	0.79866917976589	0.979628232635575	0.169673447599406	0.959159975702413	0.483015668880262	1499335.01530309	1691518.00623855	989751.415380184	5.53234274481973E7	5.88619201086468E7	3.63990683013196E7	1.35123643610626E7	1.30555597235297E7	1.53773176128868E7	6.80333035906639E7	6.55922447276284E7	4.55601360762201E7	1.71661195678148E7	9511844.25395737	2.43703078917008E7
Q3U962	Collagen alpha-2(V) chain [OS=Mus musculus]	518.514	64	57	817	55	1497	144.9	cell organization and biogenesis;developmental processes;other biological processes	extracellular matrix;other cell component	extracellular structural activity;other molecular function	12832	ENSMUSG00000026042	Col5a2	mmu:12832; Q3TVR2; Q3U962; Q3UHK7; Q3UTT4; Q3V1J6; Q61431; Q7TMS0; Q80VS8	Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion	Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions	1.598	1.546	1.519	1.021	0.385	3.505	0.525	2.477	0.861384746267066	0.961254912149485	0.730324052254867	0.632833892117728	0.0769666553885184	0.273444295895674	0.453486790198347	0.973358018692255	1.96082795853326E7	1.89754303457921E7	3.46758133166589E7	4.80275081428664E7	4.79991185130461E7	4.1747532446715E7	1.59204573672189E7	1.42782577106181E7	1.7061559679881E7	2.09575588581227E7	1.96948053072084E7	2.25862916575107E7	1.85137908486988E7	4881772.8383399	8018525.34642114
Q05793	Basement membrane-specific heparan sulfate proteoglycan core protein [OS=Mus musculus]	507.28	33	84	998	84	3707	398	cell organization and biogenesis;transport;developmental processes;other biological processes	non-structural extracellular;extracellular matrix;ER/Golgi	other molecular function	15530		Hspg2	mmu:15530; Q05793			7.351	4.161	3.918	5.169	0.496	1.868	0.437	2.1	0.332090710292395	0.382764581022518	0.771134174410141	0.553652046981626	0.208890689478245	0.938381933295379	0.285967432697218	0.908661395894721	136795.508290338	206406.403199821	169825.859706297	3.70110206606215E7	4.34630743166815E7	4.28074794537461E7	2.41165287907714E7	1.91842080304052E7	2.07659482289725E7	2.10452863152835E7	2.06741361608803E7	1.52751209810576E7	8226367.86740312	5927226.99682882	1.0580617159021E7
Q61554	Fibrillin-1 [OS=Mus musculus]	499.202	38	86	1117	86	2873	312.1	cell adhesion;other metabolic processes;developmental processes;signal transduction;other biological processes	non-structural extracellular;extracellular matrix	signal transduction activity or receptor binding;extracellular structural activity;other molecular function	14118	ENSMUSG00000027204	Fbn1	A2AQ53; mmu:14118; Q60826; Q61554	Comprehensive IL-17A signaling	Integrin cell surface interactions; Degradation of the extracellular matrix; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; TGF-beta receptor signaling activates SMADs; Molecules associated with elastic fibres	18.996	8.247	8.911	3.018	0.396	2.1	0.276	3.153	0.0596853092747711	0.0840496117897429	0.378389090130589	0.84258396038376	0.087482121441914	0.862063111456553	0.0455630470425967	0.77820123247099	95282.9912894267	109686.773968107	40225.7464170883	5.82457893686458E7	6.62931141873392E7	3.19536333419291E7	2.33066180631659E7	1.9035713753758E7	2.29784126659734E7	2.39841959808407E7	2.29999435869113E7	1.54925740961197E7	5514536.56061601	2575605.08863811	7345083.32475891
Q8BTM8	Filamin-A [OS=Mus musculus]	493.069	49	91	915	83	2647	281	cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes	plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component	signal transduction activity or receptor binding;cytoskeletal activity;other molecular function	192176	ENSMUSG00000031328	Flna	B7FAV0; O54934; Q7TQI1; Q8BLK1; Q8BTM8; Q8BTN7; Q8VHX5; Q8VHX8; Q99KQ2	Mapk signaling pathway; Focal adhesion	Platelet degranulation ; Cell-extracellular matrix interactions; RHO GTPases activate PAKs; GP1b-IX-V activation signalling	16.184	3.535	15.745	4.108	1.303	2.08	0.901	2.899	0.0844935092512095	0.493514006575528	0.170420349138264	0.67528135146603	0.946239447314336	0.864215513767001	0.904360680536565	0.8468455705593	223080.302738683	192779.021360071	239583.24348992	1.21506602248127E7	1.23160583881327E7	9719435.76620134	4325195.00464495	4176073.86658823	6355593.34436329	1.73054238441738E7	1.42527501066511E7	1.24998953996761E7	4531038.34565544	2879720.55833739	5479053.39146785
P02463	Collagen alpha-1(IV) chain [OS=Mus musculus]	487.707	70	68	828	68	1669	160.6	cell organization and biogenesis;developmental processes;signal transduction;other biological processes	non-structural extracellular;extracellular matrix	extracellular structural activity;other molecular function	12826	ENSMUSG00000031502	Col4a1	mmu:12826; P02463; Q3UHJ4; Q3UJE7; Q3UQV2; Q53X35; Q6GQS7; Q6PHB5; Q99LQ8	Spinal cord injury; Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion	Laminin interactions; Signaling by PDGF; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions	4.371	1.004	11.171	2.458	3.498	3.947	1.69	4.683	0.604225174343649	0.68008321917751	0.284160251285083	0.936818656936794	0.483508479481234	0.167300285011781	0.777395712279767	0.224623005929948	359769.877634713	285958.835932462	141085.539092917	2.00868956379824E7	2.17854047157598E7	2.25190928918174E7	4657081.16483192	4119739.1632835	5084724.84322114	3.91843343162395E7	3.69562703398771E7	2.33283395840594E7	7286914.931104	6193195.94075903	1.32557370999003E7
Q60847	Collagen alpha-1(XII) chain [OS=Mus musculus]	480.266	40	95	991	95	3120	340	cell adhesion;developmental processes	other cell component		12816	ENSMUSG00000032332	Col12a1	mmu:12816; P70322; Q60847		Assembly of collagen fibrils and other multimeric structures; Collagen chain trimerization; Collagen degradation	15.041	20	9.674	12.612	0.427	0.631	0.21	1.243	0.0975092237649803	1.8644578313253E-17	0.344512840834051	0.162753188077458	0.119424004207039	0.101350980560035	0.0103905836841461	0.266844028199729	98450.5264125119	58090.3600627237	83999.6481680613	3.34408474370425E7	3.89438836318894E7	1.74727378978336E7	5.74848700994307E7	4.49447732262548E7	5.27793485517261E7	1.71723257401258E7	1.50709974901674E7	1.16453026750935E7	1.0899125462023E7	6848854.24799245	1.38653609093446E7
Q8VDD5	Myosin-9 [OS=Mus musculus]	418.364	45	73	827	60	1960	226.2	cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;stress response;transport;developmental processes;other biological processes	plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component	signal transduction activity or receptor binding;cytoskeletal activity;other molecular function	17886	ENSMUSG00000022443	Myh9	mmu:17886; Q3UHT9; Q3UHU4; Q6KAN6; Q811I2; Q8VDD5	Primary focal segmental glomerulosclerosis (FSGS)	RHO GTPases activate PAKs; Regulation of actin dynamics for phagocytic cup formation	11.694	10.853	19.492	13.21	2.21	1.427	1.339	2.347	0.156498497144098	0.0382609387499984	0.118876667035285	0.15125389278925	0.87421335771164	0.916542675526027	0.91728043005175	0.990873516209569	107483.529676039	153800.887463573	39674.4269878413	8783012.74886087	9974545.70796386	5444477.78467149	4748384.28257292	4410554.6604061	6370665.87897293	2.10207699044932E7	2.09758895852136E7	1.72823293907493E7	8538625.93793802	5517905.75659883	9476865.41359831
Cont_P02453	Collagen alpha-1(I) chain OS=Bos taurus OX=9913 GN=COL1A1 PE=1 SV=3	414.689	43	43	1208	4	1463	138.9	cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes	non-structural extracellular;extracellular matrix;other cell component	extracellular structural activity;other molecular function	282187	ENSBTAG00000013103	COL1A1	bta:282187; P02453; Q3MHM2	Inflammatory response pathway; Osteoblast signaling; Focal adhesion	Fibronectin matrix formation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Collagen degradation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; Collagen chain trimerization; GPVI-mediated activation cascade; Platelet Aggregation (Plug Formation); Platelet Adhesion to exposed collagen; GP1b-IX-V activation signalling	1.443	0.869	1.124	1.501	0.374	1.284	0.335	0.775	0.800889767710788	0.579410556046386	0.58548007712969	0.839216523231753	0.067749585016969	0.848119069115724	0.108042253370914	0.0107964100780951	246464.336302772	276104.509600215	163058.776827813	4343807.62117337	4270443.00602544	3115927.46864821	3219828.72869598	3183952.03023541	3383679.40073467	941743.224351002	1075861.66368366	756862.710693879	1364509.18546901	876331.391932507	1065336.29340721
Cont_P02769	Albumin OS=Bos taurus OX=9913 GN=ALB PE=1 SV=4	390.555	81	57	7095	54	607	69.2	stress response;other biological processes	non-structural extracellular;other cell component	nucleic acid binding activity;other molecular function	280717		ALB	A5PJX3; bta:280717; O02787; P02769; P04277; Q3SZR2			0.86	0.957	1.154	0.79	1.314	0.876	0.791	1.45	0.520832629933248	0.650544967914241	0.598172767155558	0.497906326712893	0.946568086066385	0.413798631523592	0.846117085258013	0.468531677746422	3.41035277502904E9	3.06531085647989E9	1.66716629813739E9	2.0547979326133E9	2.37062763488737E9	2.78500610382043E9	3.09362764542436E9	2.55631644026836E9	3.07992745656962E9	2.97814649224141E9	2.86277256421772E9	2.21144220575444E9	1.66052966718895E9	2.22855277531216E9	3.25384623573346E9
P01027	Complement C3 [OS=Mus musculus]	388.541	53	70	1148	62	1663	186.4	cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes	non-structural extracellular;other cell component	signal transduction activity or receptor binding;enzyme regulator activity	12266	ENSMUSG00000024164	C3	mmu:12266; P01027; Q61370; Q80XP1	Complement activation, classical pathway; Tyrobp causal network in microglia; Comprehensive IL-17A signaling	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade; Neutrophil degranulation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; G alpha (i) signalling events; Peptide ligand-binding receptors; Alternative complement activation; Activation of C3 and C5	3.547	2.537	6.803	3.529	1.878	2.911	2.425	2.35	0.712660037675161	0.729783028721347	0.506101547380209	0.762068821001752	0.939492000987438	0.512232143465318	0.413470300505934	0.991722673088443	4040096.73815256	3926631.83282415	1843021.41157313	4.04154698805798E7	4.4896658832648E7	4.8335201547635E7	1.80671896153384E7	1.47828809765086E7	1.7121367805152E7	9.88883606977539E7	8.1974398309486E7	5.99376709525504E7	3.21393016835685E7	2.84159228355073E7	4.96444404075474E7
Cont_Q7SIH1	Alpha-2-macroglobulin OS=Bos taurus OX=9913 GN=A2M PE=1 SV=2	370.864	53	56	1089	56	1510	167.5		non-structural extracellular	enzyme regulator activity;other molecular function	513856	ENSBTAG00000018137	A2M	A8E647; bta:513856; Q7SIH1	IL-6 signaling pathway		1.169	1.273	1.523	0.809	1.276	0.967	0.649	1.845	0.688450665125024	0.839052280267302	0.731111241255251	0.509007335932165	0.944154202827561	0.540124873725708	0.671798309985569	0.809503222445875	5.71770657169572E7	6.35766951637367E7	4.19549690627817E7	6.46032237401637E7	7.37926671048822E7	7.2164410166051E7	8.06000315293491E7	7.23429494984619E7	7.40068576999505E7	8.7810317845685E7	9.50258669209954E7	6.46884849507494E7	4.10565401116459E7	3.96461495018234E7	7.63451634810678E7
Cont_Q29443	Serotransferrin OS=Bos taurus OX=9913 GN=TF PE=2 SV=1	343.183	74	48	1709	46	704	77.7	stress response;transport;other biological processes	non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle	other molecular function	280705		TF	bta:280705; Q0IIK2; Q29443			1.017	1.563	1.16	0.912	1.118	0.635	0.55	1.293	0.615274986253429	0.964709887217926	0.600414647182016	0.571407162236119	0.902231721267411	0.105569810421019	0.506704636011438	0.313748671859839	1.71679936327392E8	1.91001417946965E8	8.41149187199369E7	1.24867801818358E8	1.55146358811954E8	1.88178132242021E8	2.69795837029218E8	2.21755859229163E8	2.04768415701638E8	1.81082969779594E8	1.61167381210782E8	1.45463022007429E8	9.18433757916485E7	1.38609619584445E8	1.76572700073531E8
Cont_P07589	Fibronectin OS=Bos taurus OX=9913 GN=FN1 PE=1 SV=4	337.517	26	47	923	11	2478	272	cell adhesion;cell organization and biogenesis;stress response;developmental processes;other biological processes	non-structural extracellular	signal transduction activity or receptor binding;other molecular function			FN1	P07589			3.52	3.363	2.311	1.395	0.714	1.039	0.476	1.31	0.714071857030863	0.525827426782658	0.94971810013306	0.802863674292211	0.553450172742796	0.634088329627404	0.35834247597224	0.281927255363179	142865.797461343	209169.389049115	146732.075795441	1055759.20189889	1052518.92691246	748231.640959004	927817.269350189	797644.80797335	782189.414628216	683356.768802769	735882.167003896	388557.285212602	606468.327162644	334439.098432858	506951.879121439
Q80X90	Filamin-B [OS=Mus musculus]	335.882	38	75	608	66	2602	277.7	cell organization and biogenesis;stress response;other biological processes	plasma membrane;other membranes;cytosol;cytoskeleton;other cell component	cytoskeletal activity;other molecular function	286940	ENSMUSG00000025278	Flnb	E9QNV9; mmu:286940; Q80X90; Q8VHX4; Q8VHX7; Q99KY3		ISG15 antiviral mechanism	7.928	5.332	12.124	4.491	1.209	1.979	0.842	2.845	0.296944306247309	0.238365792894698	0.254729742039053	0.629546282386664	0.936411452199724	0.897564267605108	0.872448101434609	0.866446545996913	201569.562939035	74814.3999578854	187488.727848728	5908241.65562211	7025090.54357015	5213153.27323614	2307098.04671866	1545558.91097354	3200680.70273347	8948631.41531232	7437294.37435051	6391778.7211006	1867290.64861647	1318356.62479586	2409815.97001446
Cont_P35527	Keratin, type I cytoskeletal 9 OS=Homo sapiens OX=9606 GN=KRT9 PE=1 SV=3	310.424	69	35	915	34	623	62	cell organization and biogenesis;other biological processes	cytosol;cytoskeleton	cytoskeletal activity	3857	ENSG00000171403	KRT9	hsa:3857; O00109; P35527; Q0IJ47; Q14665		Formation of the cornified envelope	1.535	1.081	1.647	2.287	1.044	1.471	2.208	0.777	0.836660982916281	0.73072258897653	0.769556732848094	0.964570089320365	0.873609880131656	0.936669139837906	0.516448827835279	0.0110179641295352	3.00988862408693E7	2.22166955848562E7	3.53566605858277E7	3.83413938796298E7	4.01115354911529E7	4.55013850626263E7	3.25056930591839E7	3.99576081794461E7	2.50556157717982E7	4.79768166310243E7	2.93517742058567E7	7.69722436015544E7	1.31711700890849E8	9.27838604678364E7	5.6604390657593E7
Cont_P04264	Keratin, type II cytoskeletal 1 OS=Homo sapiens OX=9606 GN=KRT1 PE=1 SV=6	306.58	65	45	1774	36	644	66	cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes	non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component	bone, tooth or skin structural activity;other molecular function	3848	ENSG00000167768	KRT1	B2RA01; hsa:3848; P04264; P85925; P86104; Q14720; Q6GSJ0; Q9H298	Corticotropin-releasing hormone signaling	Formation of the cornified envelope; Neutrophil degranulation; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	1.103	0.963	1.229	2.667	1.042	1.184	2.925	0.472	0.65780924735352	0.653826967689551	0.631165145316661	0.89629386854896	0.873609880131656	0.770634810212039	0.254077056479593	5.78940441291519E-5	1.31038801811221E8	1.49848314576813E8	1.81048519054156E8	1.64179912336924E8	1.70861004616453E8	1.60803236136221E8	1.32005397364365E8	1.61355773356369E8	1.09071204525108E8	1.84835731298625E8	1.38277867637903E8	2.0582953187505E8	6.47574942932283E8	3.95085049343759E8	3.00261678765842E8
P06909	Complement factor H [OS=Mus musculus]	292.01	49	41	540	41	1234	139	cell adhesion;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes	non-structural extracellular;plasma membrane;other membranes;mitochondrion;other cell component	other molecular function	12628	ENSMUSG00000026365	Cfh	mmu:12628; P06909; Q6NZK3		Regulation of Complement cascade	10	11.089	20	8.058	2.955	0.961	0.704	3.964	0.205200089226065	0.0359547312524068	1.50457038391225E-17	0.329485122608543	0.678323397545056	0.532399788858771	0.750662231008662	0.443116920082088	45833.2314948132	5719.34924483144	127074.400703141	9199603.23733176	9631512.57691777	1.22513356989878E7	1.13946236540082E7	8948376.12127358	1.13575209573925E7	3.40837407850627E7	2.84575354110008E7	2.55312981422866E7	7658800.41775084	6857257.31092971	1.08034871236965E7
P16546	Spectrin alpha chain, non-erythrocytic 1 [OS=Mus musculus]	291.854	35	74	473	74	2472	284.4	cell organization and biogenesis	plasma membrane;other membranes;cytosol;cytoskeleton;other cell component	cytoskeletal activity;other molecular function	20740	ENSMUSG00000057738	Sptan1	A3KGU6; A3KGU8; P16546; Q8K380; Q9CT05	FAS pathway and stress induction of HSP regulation	Neutrophil degranulation; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Interaction between L1 and Ankyrins; COPI-mediated anterograde transport; RHOU GTPase cycle; RHOV GTPase cycle; Caspase-mediated cleavage of cytoskeletal proteins	2.273	1.172	5.466	1.689	1.972	2.321	1.488	2.88	0.958962194559628	0.786160319109602	0.611910908670005	0.890289034593217	0.929383260195332	0.771887919257916	0.870511801558508	0.852906094467594	889916.065158961	705414.766907556	458549.490375553	4175162.43226982	4600176.71769719	3155429.78771999	1301153.76848032	907755.21332001	2072924.21437361	9282178.93349268	8610756.12905297	6522130.81446154	2340149.67970916	1477626.07784989	2972528.81421804
Cont_P13645	Keratin, type I cytoskeletal 10 OS=Homo sapiens OX=9606 GN=KRT10 PE=1 SV=6	286.713	62	30	1322	20	584	58.8	cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes	plasma membrane;cytosol;cytoskeleton;other cell component	bone, tooth or skin structural activity;other molecular function	3858	ENSG00000186395	KRT10	hsa:3858; P13645; Q14664; Q8N175		Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	0.992	0.771	1.072	2.427	0.958	1.365	2.951	0.443	0.600890052902075	0.490821286240141	0.561934876627864	0.941696908693733	0.829734761131295	0.880940844456856	0.246231694954624	2.55433624902191E-5	8.57039306780817E7	1.2308209015436E8	1.23973335952419E8	1.09050331614224E8	1.30109606828786E8	1.02692161896587E8	8.73473050095944E7	1.23031831133367E8	7.19147674496861E7	1.29238189237995E8	9.43248217623685E7	1.03859326412487E8	5.11249836753994E8	2.4676744393623E8	2.01230291385254E8
Cont_P35908	Keratin, type II cytoskeletal 2 epidermal OS=Homo sapiens OX=9606 GN=KRT2 PE=1 SV=2	284.975	78	42	1022	32	639	65.4	cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes	plasma membrane;cytosol;cytoskeleton;other cell component	bone, tooth or skin structural activity;cytoskeletal activity	3849	ENSG00000172867	KRT2	hsa:3849; P35908; Q4VAQ2		Formation of the cornified envelope	0.827	0.688	1.032	1.836	1.146	1.306	2.733	0.542	0.499413631103761	0.411258958244596	0.544106843431104	0.933570718645937	0.912218866069753	0.862063111456553	0.309041843038519	2.9837536993241E-4	2.56957016834685E7	6.51011422173888E7	5.25056794690703E7	3.16465014359267E7	4.04662454773149E7	3.03458785296059E7	2.58420950665494E7	4.44581259999837E7	1.77732081549674E7	3.88601529372083E7	2.41897353529024E7	4.54682916268081E7	9.79668081708945E7	6.73715830359901E7	6.38856203067551E7
Q62059	Versican core protein [OS=Mus musculus]	279.715	17	44	1073	44	3357	366.6	cell adhesion;developmental processes	non-structural extracellular;extracellular matrix;other cell component	other molecular function			Vcan	Q62058; Q62059; Q9CUU0		ECM proteoglycans; Glycosaminoglycan-protein linkage region biosynthesis; CS/DS degradation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; CS-GAG biosynthesis; DS-GAG biosynthesis	20	20	20	20	1.005	1.018	0.536	1.805	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.854305439376382	0.613304974369123	0.478009151463064	0.783304059803245	125473.726574878	146060.097046071	41031.8651630982	8.44868881898379E7	1.01917408783468E8	9.76252353450265E7	1.00104936351016E8	8.17450473009677E7	8.92610512588614E7	1.04839173391366E8	1.06605513712809E8	7.38631920533055E7	5.09261453344577E7	4.44571187520766E7	8.14544543672178E7
P10493	Nidogen-1 [OS=Mus musculus]	275.191	43	42	852	42	1245	136.5	cell adhesion;cell organization and biogenesis;developmental processes;other biological processes	non-structural extracellular;extracellular matrix;other cell component	other molecular function	18073	ENSMUSG00000005397	Nid1	mmu:18073; P10493; Q3TKX9; Q8BQI3; Q8C3U8; Q8C9P6		Laminin interactions; Degradation of the extracellular matrix	20	20	12.26	6.185	0.272	1.009	0.083	3.135	1.65082956259427E-17	1.8644578313253E-17	0.251140212279038	0.461941385639594	0.013229256333524	0.604382524464811	1.0740690550749E-5	0.781368126060588	439897.722361698	266111.080129006	261357.080833752	1.30583493944604E8	1.41493313555848E8	1.08068734992402E8	1.1764867041349E8	1.23903817347262E8	1.22059347123012E8	3.85653673006923E7	3.40794335543811E7	2.32700802472122E7	8950100.03941293	6809358.71273179	1.16807558295498E7
O88207	Collagen alpha-1(V) chain [OS=Mus musculus]	275.025	46	52	413	44	1838	183.6	cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes	extracellular matrix;other cell component	extracellular structural activity;other molecular function	12831	ENSMUSG00000026837	Col5a1	A3KGE3; mmu:12831; O88207; Q3UG94; Q6F6B0	Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion	ECM proteoglycans; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; MET activates PTK2 signaling	20	20	11.658	8.419	0.482	2.145	0.446	1.84	1.65082956259427E-17	1.8644578313253E-17	0.268653947705267	0.311207075116757	0.189625712887896	0.848119069115724	0.302671730722046	0.809503222445875	12502.6007438316	105962.872602761	122701.039249758	8585864.47184676	9052435.86465399	8047799.6262338	3715509.90739661	3183478.03245453	3834509.14396516	3548034.64380386	3694879.64301103	2052789.86607006	1322438.93167649	910135.702053452	1926767.56075777
P37889	Fibulin-2 [OS=Mus musculus]	269.894	43	37	791	37	1221	131.7	other biological processes	non-structural extracellular	other molecular function	14115	ENSMUSG00000064080	Fbln2	G5E8B3; mmu:14115; P37889; Q9WUI2		Molecules associated with elastic fibres	20	9.095	14.207	9.595	0.657	1.229	0.44	1.856	1.65082956259427E-17	0.0640195441309023	0.201227492083465	0.255240026777032	0.453005417011507	0.803447472095846	0.290132264062119	0.809503222445875	404936.27628206	303410.824570497	379728.902265123	7.35240092421165E7	8.16716617206073E7	8.54486063918813E7	7.34239875271171E7	6.18846762513378E7	6.13955038440774E7	5.64407337496573E7	5.35180097543675E7	3.80873889057723E7	2.96696416762988E7	2.21115750486307E7	3.84218730879294E7
Q8VHX6	Filamin-C [OS=Mus musculus]	249.498	31	65	425	56	2726	290.9	cell organization and biogenesis;other biological processes	plasma membrane;other membranes;cytosol;cytoskeleton;other cell component	cytoskeletal activity	68794	ENSMUSG00000068699	Flnc	B2RY80; B9EKT2; mmu:68794; Q6PAI6; Q8VHX6; Q9JJ38		Cell-extracellular matrix interactions	0.924	1.063	2.364	0.915	1.621	1.781	0.941	3.029	0.562594032195739	0.719627996749639	0.962331548063155	0.57290809187594	0.976873891151678	0.96786708205164	0.933437821008547	0.80954066750699	362673.376414211	453714.7830589	401875.758519269	2896613.16388353	1997446.07055639	1374740.24453431	898320.393102247	899851.262035181	1251187.76236098	4619845.64928082	4224920.76413233	4533386.9985568	889222.28002913	1245417.60281572	1275359.84004796
Q04857	Collagen alpha-1(VI) chain [OS=Mus musculus]	248.981	44	33	588	33	1025	108.4	cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes	non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component	other molecular function	12833	ENSMUSG00000001119	Col6a1	mmu:12833; Q04857		ECM proteoglycans; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Signaling by PDGF; NCAM1 interactions	8.793	4.087	2.364	2.258	0.328	1.748	0.341	1.364	0.2534363617947	0.392208211277376	0.962331548063155	0.971216996811237	0.0353343473113635	0.97504218639442	0.115965329440656	0.380888676065133	99442.7570537982	67304.0023261046	63848.8638629308	6.50338448192604E7	8.11264443817216E7	6.12675161034549E7	5.28406132873544E7	4.53711044962942E7	5.19951028566589E7	2.08305860584001E7	2.24322225654869E7	1.63957751491443E7	1.39653990737858E7	1.00181099527419E7	1.94360212112643E7
Cont_Q2UVX4	Complement C3 OS=Bos taurus OX=9913 GN=C3 PE=1 SV=2	247.154	39	55	851	47	1661	187.1	cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes	non-structural extracellular;other cell component	signal transduction activity or receptor binding;enzyme regulator activity	280677	ENSBTAG00000017280	C3	bta:280677; Q2KIZ4; Q2UVX4	Complement and coagulation cascades; Complement activation, classical pathway	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Neutrophil degranulation; Peptide ligand-binding receptors; G alpha (i) signalling events; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade; Alternative complement activation; Activation of C3 and C5	1.019	1.197	1.097	0.804	1.068	0.796	0.594	1.431	0.615680953989958	0.798729234704005	0.573945385766997	0.506364847510615	0.87421335771164	0.291700662163587	0.591028379533681	0.448532796991499	1.66248121121728E7	1.69271139045693E7	1.05083515570206E7	1.25526666866144E7	1.76991579704635E7	1.56235874907449E7	1.80944158276855E7	1.82336027421103E7	1.90370193770683E7	1.87583360164926E7	1.78001813666833E7	1.18248646641963E7	8899645.14317005	9025681.5960692	1.79617171787325E7
Q62261	Spectrin beta chain, non-erythrocytic 1 [OS=Mus musculus]	244.684	30	61	398	61	2363	274.1	cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes	plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component	cytoskeletal activity;other molecular function	20742	ENSMUSG00000020315	Sptbn1	A2AFU1; mmu:20742; Q3TEM7; Q5SQL8; Q5SQL9; Q62261; Q9QWJ7		COPI-mediated anterograde transport; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; RHOU GTPase cycle; Interaction between L1 and Ankyrins; RHOV GTPase cycle	1.181	1.156	1.412	1.471	1.95	2.087	1.904	2.22	0.69394578118832	0.776437620310661	0.693719649766064	0.831411077141515	0.937876734191067	0.86315143463057	0.664971370235365	0.953305976192702	373834.445440549	533726.562973047	569801.107945045	3103526.47805657	3181731.16602619	2477755.42998989	796281.087102098	609431.872132576	1356947.15467432	7745784.08821259	6610112.71623617	4897418.35730506	2432765.02616441	1743474.26371724	2723698.32906552
Q640N1	Adipocyte enhancer-binding protein 1 [OS=Mus musculus]	239.707	38	34	648	34	1128	128.3	protein metabolism;other biological processes	nucleus;other cell component	nucleic acid binding activity;other molecular function	11568	ENSMUSG00000020473	Aebp1	mmu:11568; O88442; Q3TVV5; Q3TWA7; Q3TX56; Q3TXB2; Q5NCI9; Q61281; Q640N1			8.459	10.223	5.53	4.478	0.703	1.165	0.36	2.258	0.269326617826563	0.0457359864845759	0.605387748357992	0.631359014803774	0.534291750451691	0.760992448481534	0.145805028390539	0.963436677882021	3560033.84712119	4696620.34449178	6275149.80645163	4.59930845855363E7	5.69735867783534E7	2.04646374454636E7	3.80233154774145E7	4.02615711999708E7	4.03854487434811E7	3.40966164303398E7	3.7490792004469E7	2.41166240785119E7	1.4983671743246E7	1.40971982755857E7	2.68643149803103E7
P57780	Alpha-actinin-4 [OS=Mus musculus]	239.42	58	45	483	30	912	104.9	cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes	cytoskeleton;nucleus;other cell component	cytoskeletal activity;other molecular function	60595	ENSMUSG00000054808	Actn4	mmu:60595; P57780	Primary focal segmental glomerulosclerosis (FSGS)	Platelet degranulation	20	20	20	11.478	1.18	2.264	1.041	2.59	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	0.19149089837131	0.921882153462399	0.795351011232032	0.968364585136618	0.938282411159324	5221.79731213346		36578.541519335	9107610.67207618	1.00453975465233E7	1.03378326393571E7	5095419.11923033	3409382.50707632	5238186.41277381	1.31020350186557E7	1.2711162036506E7	9162046.18669404	4501757.36231035	3002316.05426355	5816939.08777499
Q7TPR4	Alpha-actinin-1 [OS=Mus musculus]	235.529	54	42	511	27	892	103	cell adhesion;cell organization and biogenesis;other biological processes	plasma membrane;other membranes;cytoskeleton;other cell component	signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function	109711	ENSMUSG00000015143	Actn1	mmu:109711; Q7TPR4	Regulation of actin cytoskeleton; Integrin-mediated cell adhesion; Focal adhesion	Platelet degranulation ; RHOF GTPase cycle; RHOBTB2 GTPase cycle; RHOD GTPase cycle; Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	2.068	0.45	1.822	2.422	1.639	2.396	1.586	2.793	0.995554138371554	0.178726136005694	0.819280225722906	0.941696908693733	0.974207409660283	0.744084716394381	0.837231569641376	0.879972045955715	354073.059499792	209249.076355465	897084.460899514	5526121.35104279	6211867.70337129	6893436.45630869	2413615.48536692	1933168.81934458	3229981.90899851	1.03807818109957E7	1.11771340173328E7	8282960.99949337	3416305.89125481	2797115.44078374	4939050.64701654
P02468	Laminin subunit gamma-1 [OS=Mus musculus]	230.882	35	43	454	43	1607	177.2	cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes	non-structural extracellular;extracellular matrix;other cell component	extracellular structural activity;other molecular function			Lamc1	P02468			13.572	7.288	7.506	4.094	0.559	2.029	0.482	2.135	0.118212047511996	0.116315527815218	0.459134305737471	0.675951294045723	0.3041568870489	0.877818946381645	0.368062651583427	0.922276466908065	14325.5972836352	21883.5466161272		1.5357350900924E7	1.57310961044729E7	1.74335709018572E7	7496762.71625721	6775968.90045745	7708775.93718172	9245241.37337628	9035989.05815721	5573559.97495901	2765122.91380764	2368540.67041914	4605215.17131646
Q91ZX7	Prolow-density lipoprotein receptor-related protein 1 [OS=Mus musculus]	230.497	15	57	519	56	4545	504.4	other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes	plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component	signal transduction activity or receptor binding;other molecular function	16971		Lrp1	mmu:16971; Q61291; Q91ZX7; Q920Y4	Statin pathway; Wnt signaling pathway	Scavenging of heme from plasma; Retinoid metabolism and transport	20	13.648	18.208	13.235	0.805	1.902	0.692	2.078	1.65082956259427E-17	0.0181625429641231	0.133639440745791	0.150830220548111	0.687557067265551	0.925871264502428	0.74148782464906	0.901098484497789	10237.2255539891		51104.3489937616	6875342.47952318	6944806.90573824	8247481.69257335	4299652.1243919	2953538.60705284	3392031.85738558	6405748.2654286	5854087.4911046	4914685.84613499	2044471.2247951	1705219.62694462	2981142.11204421
Cont_P60712	Actin, cytoplasmic 1 OS=Bos taurus OX=9913 GN=ACTB PE=1 SV=1	225.45	70	19	852	2	375	41.7	cell organization and biogenesis;stress response;developmental processes;other biological processes	plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component	enzyme regulator activity;cytoskeletal activity;other molecular function	100033878; 100135470; 100173832; 101844587; 102139853; 11461; 118833809; 280979; 396526; 403580; 414396; 443052; 450133; 60; 81822	ENSBTAG00000026199; ENSCAFG00000016020; ENSCAFG00030015381; ENSCAFG00040015695; ENSCPOG00000013467; ENSG00000075624; ENSMAUG00000008763; ENSMUSG00000029580; ENSOARG00040012985; ENSOARG00180022443; ENSOARG00185023855; ENSOARG00215030140; ENSOARG00225009314; ENSPPYG00000017336; ENSPTRG00000018890; ENSRNOG00000034254; ENSSSCG00000007585; ENSSSCG00030003451; ENSSSCG00035038792; ENSSSCG00040049462; ENSSSCG00045027458; ENSSSCG00050065025; ENSSSCG00055012597; ENSSSCG00060019124; ENSSSCG00065037921; ENSSSCG00070011353; ENSSSCG00105030144; ENSSSCG00110026965; ENSSSCG00115013637; ENSSSCG00130033784	Actb; ACTB	A5D961; A5PKA1; bta:280979; cfa:403580; cpoc:100135470; csab:103246953; ecb:100033878; gga:396526; hsa:60; maua:101844587; mmu:11461; O18840; oas:443052; P02570; P60706; P60707; P60708; P60709; P60710; P60711; P60712; P60713; P70514; P99021; pon:100173832; ptr:450133; Q11209; Q11211; Q3SZD2; Q3TI89; Q3TVP6; Q4L0Y2; Q4R561; Q5R1X3; Q5R582; Q5R6G0; Q64316; Q6QAQ1; Q6ZWM3; Q711N9; Q71FK5; Q75MN2; Q76N69; Q8MIJ0; Q8SPX4; Q95164; Q96B34; Q96HG5; rno:81822; ssc:414396	FAS pathway and stress induction of HSP regulation; Actin cytoskeleton regulation; Myometrial relaxation and contraction pathways; Focal adhesion; Arrhythmogenic right ventricular cardiomyopathy; Pathogenic Escherichia coli infection; Common pathways underlying drug addiction; Myometrial relaxation and contraction pathways; Focal adhesion; Fas ligand pathway and stress induction of heat shock proteins; Pathogenic Escherichia coli infection; Arrhythmogenic right ventricular cardiomyopathy; Focal adhesion; Myometrial relaxation and contraction pathways; Regulation of actin cytoskeleton; Myometrial relaxation and contraction pathways; Ebola virus infection in host; Acute viral myocarditis; Thermogenesis; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Overlap between signal transduction pathways contributing to LMNA laminopathies; Pleural mesothelioma; Regulation of actin cytoskeleton; Network map of SARS-CoV-2 signaling; Regulation of actin cytoskeleton; Regulation of actin cytoskeleton; Focal adhesion	Formation of the canonical BAF (cBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); Regulation of actin dynamics for phagocytic cup formation; EPH-ephrin mediated repulsion of cells; Formation of annular gap junctions; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; RHO GTPases Activate Formins; RHOF GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; B-WICH complex positively regulates rRNA expression; Regulation of CDH1 Function; Formation of the dystrophin-glycoprotein complex (DGC); Formation of the canonical BAF (cBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); RHO GTPases Activate WASPs and WAVEs; UCH proteinases; DNA Damage Recognition in GG-NER; Formation of the non-canonical BAF (ncBAF) complex; RHO GTPases activate IQGAPs; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Cell-extracellular matrix interactions; MAP2K and MAPK activation; Interaction between L1 and Ankyrins; RHOF GTPase cycle; DNA Damage Recognition in GG-NER; MAP2K and MAPK activation; RHO GTPases Activate Formins; Clathrin-mediated endocytosis; UCH proteinases; RHOF GTPase cycle; DNA Damage Recognition in GG-NER; EPH-ephrin mediated repulsion of cells; VEGFA-VEGFR2 Pathway; Regulation of actin dynamics for phagocytic cup formation; Adherens junctions interactions; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); RHO GTPases Activate WASPs and WAVEs; B-WICH complex positively regulates rRNA expression; Regulation of CDH1 Function; EPHB-mediated forward signaling; Formation of the non-canonical BAF (ncBAF) complex; Formation of the canonical BAF (cBAF) complex; Formation of annular gap junctions; RHO GTPases activate IQGAPs; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; RHO GTPases Activate WASPs and WAVEs; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RHO GTPases activate IQGAPs; RHO GTPases Activate Formins; RHOF GTPase cycle; Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs); B-WICH complex positively regulates rRNA expression; Signaling by BRAF and RAF1 fusions; UCH proteinases; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; VEGFA-VEGFR2 Pathway; Formation of the dystrophin-glycoprotein complex (DGC); Factors involved in megakaryocyte development and platelet production; Regulation of MITF-M-dependent genes involved in pigmentation; Formation of the canonical BAF (cBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); EPH-ephrin mediated repulsion of cells; HATs acetylate histones; Interaction between L1 and Ankyrins; Prefoldin mediated transfer of substrate to CCT/TriC; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Adherens junctions interactions; Regulation of CDH1 Function; Formation of the non-canonical BAF (ncBAF) complex; DNA Damage Recognition in GG-NER; Formation of the polybromo-BAF (pBAF) complex; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Formation of annular gap junctions; Folding of actin by CCT/TriC; Cell-extracellular matrix interactions; MAP2K and MAPK activation; RHO GTPases Activate Formins; Recycling pathway of L1; RHO GTPases activate IQGAPs; Clathrin-mediated endocytosis; Formation of the dystrophin-glycoprotein complex (DGC); EPHB-mediated forward signaling; UCH proteinases; B-WICH complex positively regulates rRNA expression; Adherens junctions interactions; Formation of the non-canonical BAF (ncBAF) complex; Formation of annular gap junctions; Formation of the polybromo-BAF (pBAF) complex; VEGFA-VEGFR2 Pathway; Cell-extracellular matrix interactions; RHO GTPases Activate WASPs and WAVEs; Regulation of CDH1 Function; Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; UCH proteinases; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); Formation of the polybromo-BAF (pBAF) complex; B-WICH complex positively regulates rRNA expression; DNA Damage Recognition in GG-NER; Formation of the canonical BAF (cBAF) complex; RHO GTPases Activate Formins; Regulation of CDH1 Function; Interaction between L1 and Ankyrins; RHOF GTPase cycle; Formation of the non-canonical BAF (ncBAF) complex; Adherens junctions interactions; Formation of the dystrophin-glycoprotein complex (DGC); VEGFA-VEGFR2 Pathway; RHO GTPases Activate WASPs and WAVEs; Cell-extracellular matrix interactions; EPHB-mediated forward signaling; MAP2K and MAPK activation; Recycling pathway of L1; RHO GTPases activate IQGAPs; Formation of annular gap junctions; B-WICH complex positively regulates rRNA expression; UCH proteinases; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); MAP2K and MAPK activation; Formation of the polybromo-BAF (pBAF) complex; RHO GTPases Activate Formins; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases Activate WASPs and WAVEs; Formation of the dystrophin-glycoprotein complex (DGC); VEGFA-VEGFR2 Pathway; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; DNA Damage Recognition in GG-NER; RHOF GTPase cycle; Cell-extracellular matrix interactions; Adherens junctions interactions; Formation of the non-canonical BAF (ncBAF) complex; Formation of the canonical BAF (cBAF) complex; RHO GTPases activate IQGAPs; Regulation of CDH1 Function; Gap junction degradation; Formation of annular gap junctions; Regulation of actin dynamics for phagocytic cup formation; RHOF GTPase cycle; Clathrin-mediated endocytosis; RHO GTPases Activate Formins; Cell-extracellular matrix interactions; VEGFA-VEGFR2 Pathway; Adherens junctions interactions; RHO GTPases activate IQGAPs; UCH proteinases; EPHB-mediated forward signaling; MAP2K and MAPK activation; RHO GTPases Activate WASPs and WAVEs; Formation of the dystrophin-glycoprotein complex (DGC); Formation of annular gap junctions; Formation of the canonical BAF (cBAF) complex; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of the non-canonical BAF (ncBAF) complex; Regulation of CDH1 Function	20	20	20	20	1.785	1.645	1.193	2.594	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.946568086066385	0.994348552930242	0.963278515868644	0.938282411159324	1924782.99006244	2098949.09709163	1966246.27612296	6.9333476629433E7	7.92679608662888E7	4.66219167617927E7	4.31411746831055E7	4.48147974340301E7	5.69102455002969E7	1.21577893646273E8	1.207324829685E8	8.72162161647777E7	5.58171302270344E7	3.75040107769213E7	6.67519874410893E7
P63260	Actin, cytoplasmic 2 [OS=Mus musculus]	217.791	70	19	831	2	375	41.8	cell organization and biogenesis;stress response;developmental processes;other biological processes	non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component	cytoskeletal activity;other molecular function	11465	ENSMUSG00000062825	Actg1	mmu:11465; P02571; P14104; P63260; P99022	Myometrial relaxation and contraction pathways; Regulation of actin cytoskeleton; Focal adhesion	Platelet degranulation ; RHO GTPases activate IQGAPs; Adherens junctions interactions; Regulation of CDH1 Function; RHO GTPases Activate Formins; Regulation of actin dynamics for phagocytic cup formation; Interaction between L1 and Ankyrins; MAP2K and MAPK activation; Recycling pathway of L1; Clathrin-mediated endocytosis; Formation of the dystrophin-glycoprotein complex (DGC); EPHB-mediated forward signaling; RHOF GTPase cycle; Formation of annular gap junctions; VEGFA-VEGFR2 Pathway; Cell-extracellular matrix interactions; RHO GTPases Activate WASPs and WAVEs; RHOBTB2 GTPase cycle	20	20	20	20	1	1.401	0.685	1.853	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.85271451854395	0.901789796153066	0.731487178650893	0.819844267712751				345218.530665522	243712.893345201	175067.879334021	138179.400499307	114235.784978709	184680.44906409	283414.957020267	357431.419092683	129167.257177683	191405.076269325	47386.9835565671	139954.449837086
P33434	72 kDa type IV collagenase [OS=Mus musculus]	212.03	56	30	889	30	662	74.1	cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes	extracellular matrix;plasma membrane;other membranes;cytoskeleton;mitochondrion;nucleus;other cell component	other molecular function	17390	ENSMUSG00000031740	Mmp2	mmu:17390; P33434	Lung fibrosis; IL-3 signaling pathway; Matrix metalloproteinases	Collagen degradation; Extra-nuclear estrogen signaling; EPH-ephrin mediated repulsion of cells; Activation of Matrix Metalloproteinases	6.722	1.555	9.726	3.89	1.512	3.012	2.621	1.842	0.372996577396536	0.964209443670126	0.342075680986172	0.708142491896103	0.993994198406889	0.459747209584207	0.34519376377552	0.809503222445875	1.45817945044039E7	3.99854546791863E7	2.31586213408419E7	6.16168347215595E7	6.71128653428481E7	5.47627512450794E7	2.153095933586E7	2.04088973517033E7	2.1514079157928E7	9.59427020238632E7	8.49468673692442E7	8.11217362792938E7	5.65046943814106E7	3.5725700482165E7	6.85636819548367E7
P19096	Fatty acid synthase [OS=Mus musculus]	203.372	23	48	335	48	2504	272.3	other metabolic processes;stress response;other biological processes	plasma membrane;other membranes;cytosol;ER/Golgi;other cell component	other molecular function	14104	ENSMUSG00000025153	Fasn	B1ATU8; mmu:14104; P19096; Q6PB72; Q8C4Z0; Q9EQR0	Fatty acid biosynthesis; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-9 fatty acid synthesis; Elongation of (very) long chain fatty acids	Fatty acyl-CoA biosynthesis; Vitamin B5 (pantothenate) metabolism	3.919	2.111	2.319	4.668	1.067	1.669	0.698	2.417	0.66189768147619	0.847457711018997	0.951921622352553	0.605074788683686	0.87421335771164	0.994834213681465	0.746782404466558	0.990873516209569	48161.514825801		157425.136778521	3018838.26514359	3331564.42510829	1838171.31939824	1125050.80259593	1067574.24276956	1976727.22395058	3354008.01034064	3348654.9716265	2283763.91979924	908323.020723558	618361.207888453	1151575.74161029
Cont_Q3SZ57	Alpha-fetoprotein OS=Bos taurus OX=9913 GN=AFP PE=2 SV=1	202.89	62	30	1153	29	610	68.5	other metabolic processes;developmental processes;other biological processes	non-structural extracellular;other cell component	other molecular function	506011	ENSBTAG00000017131	AFP	bta:506011; Q3SZ57		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation	0.89	1.253	1.171	0.883	1.251	0.689	0.666	1.305	0.540832988168188	0.82964085881652	0.605387748357992	0.553772240900005	0.938859506774495	0.15729598575093	0.699570390946254	0.323545662226049	4.4629857016799E7	4.39639700572647E7	2.72178105183923E7	3.15168703669999E7	4.26075077823651E7	3.4328683389093E7	4.8541823037709E7	4.32960721364381E7	4.4115949306695E7	4.61564880446121E7	4.7548077639711E7	3.504265434565E7	2.7823391939759E7	3.01476017178829E7	5.24042356620578E7
P48678	Prelamin-A/C [OS=Mus musculus]	202.607	60	37	529	36	665	74.2	cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes	other membranes;cytoskeleton;nucleus;other cell component	other molecular function	16905	ENSMUSG00000028063	Lmna	B3RH23; B3RH24; mmu:16905; P11516; P48678; P97859; Q3TIH0; Q3TTS8; Q3U733; Q3U7I5; Q3UCA0; Q3UCJ8; Q3UCU3; Q91WF2; Q9DC21	Adipogenesis genes; FAS pathway and stress induction of HSP regulation		20	17.997	17.767	20	4.584	2.32	1.381	7.656	1.65082956259427E-17	0.00670345592293191	0.139423967594304	1.70336894001643E-17	0.236076921565588	0.77212820363828	0.901149690306505	0.00692305873191716	56886.7483713492	69336.1384695612	100943.444664856	1.29312831685903E7	1.22006597313063E7	8045013.512583	3337288.2268023	3262868.75019265	5804803.63611667	6.75536277126862E7	5.59333072922179E7	3.75993669940438E7	7422846.33935557	4234323.21548912	7210898.93259597
Q02788	Collagen alpha-2(VI) chain [OS=Mus musculus]	202.37	41	36	585	36	1034	110.3	cell adhesion;signal transduction;other biological processes	non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component	other molecular function	12834	ENSMUSG00000020241	Col6a2	mmu:12834; Q02788; Q05505; Q8C972; Q8K229	Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion	ECM proteoglycans; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation	10.956	20	5.246	3.501	0.458	1.362	0.325	1.848	0.175734701097799	1.8644578313253E-17	0.633123216104285	0.767312384697355	0.156641881403766	0.880899056945259	0.0961283818482991	0.809503222445875	66343.4096791777	224638.480326659	72730.0086108415	5.06665581594054E7	6.05623117299827E7	4.51585075606234E7	4.3575871784427E7	3.72580130101725E7	4.32608904810994E7	2.4375983761655E7	2.22548052919965E7	1.51565723805374E7	1.09937351728106E7	7758608.50160191	1.64425759910943E7
P97927	Laminin subunit alpha-4 [OS=Mus musculus]	199.33	30	41	409	41	1816	201.7	cell adhesion;developmental processes;other biological processes	non-structural extracellular;extracellular matrix;other cell component	signal transduction activity or receptor binding	16775	ENSMUSG00000019846	Lama4	mmu:16775; O88785; P70409; P97927; Q14BF2	Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion	Formation of the dystrophin-glycoprotein complex (DGC); Laminin interactions; MET activates PTK2 signaling	5.298	2.886	2.789	3.143	0.574	1.89	0.55	1.892	0.496649188935323	0.645007535999596	0.952104483873957	0.825047045401531	0.329011090732691	0.929291541980042	0.50594120050135	0.819844267712751	540030.170801593	370746.050286439	259459.878107817	8261193.64464048	1.06712284071143E7	1.21929154576081E7	5309597.35327991	4688186.1422195	5379156.74886131	6459712.32980478	5951943.81149588	4870147.4483696	2541823.46940274	2775962.47504545	3878847.28463652
P20152	Vimentin [OS=Mus musculus]	183.446	60	29	762	27	466	53.7	cell organization and biogenesis;stress response;developmental processes;other biological processes	plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component	cytoskeletal activity;nucleic acid binding activity;other molecular function	22352	ENSMUSG00000026728	Vim	mmu:22352; O08704; P20152; Q8CCH1	Spinal cord injury; Primary focal segmental glomerulosclerosis (FSGS); Alpha 6 beta 4 integrin signaling pathway	Aggrephagy; Striated Muscle Contraction; Caspase-mediated cleavage of cytoskeletal proteins; RHOBTB1 GTPase cycle	20	7.872	20	13.938	2.257	5.309	1.573	6.359	1.65082956259427E-17	0.0955146622024883	1.50457038391225E-17	0.137621774180062	0.873609880131656	0.0297998664849654	0.840672080806375	0.0332723373064956	573727.34417641	968981.536762911	1794707.43115169	4.14069582585024E7	3.33312643886138E7	2.54656192896882E7	6941733.99810384	6173483.46835617	8980531.63051753	8.80704815958352E7	8.07026224155391E7	5.51524218564722E7	1.5029979690535E7	6861556.37440952	1.68923991921504E7
Q64727	Vinculin [OS=Mus musculus]	182.753	50	45	419	45	1066	116.6	cell adhesion;cell organization and biogenesis;developmental processes;other biological processes	plasma membrane;other membranes;cytoskeleton;other cell component	cytoskeletal activity;other molecular function	22330	ENSMUSG00000021823	Vcl	mmu:22330; Q64727; Q8BP32; Q8BS46; Q922C5; Q922D9	Primary focal segmental glomerulosclerosis (FSGS); IL-3 signaling pathway; Regulation of actin cytoskeleton; Integrin-mediated cell adhesion; Focal adhesion	Neutrophil degranulation; High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells; Platelet degranulation ; MAP2K and MAPK activation; Smooth Muscle Contraction; Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells; Regulation of CDH1 Function	9.889	5.909	12.691	5.698	1.39	2.026	1.158	2.519	0.208404050858596	0.190838415616571	0.238791978742132	0.504745711776551	0.964629994744883	0.878264980963866	0.977491813528386	0.958518237573655	199164.849916128	87100.0128702587	92185.322880836	5675245.0989599	5838625.66584249	3008640.49360623	1870082.63283096	1414114.90526218	2577750.73562883	7844023.43396073	7226639.25078312	5204108.91618431	2343388.9049214	1587883.53032107	3146179.30802337
Q8K4G1	Latent-transforming growth factor beta-binding protein 4 [OS=Mus musculus]	180.216	27	29	318	29	1666	178.5	cell-cell signaling;cell organization and biogenesis;transport;signal transduction	non-structural extracellular;extracellular matrix	other molecular function	108075	ENSMUSG00000040488	Ltbp4	E9QPD9; mmu:108075; Q8K4G0; Q8K4G1		TGF-beta receptor signaling activates SMADs; Molecules associated with elastic fibres	7.729	4.292	20	12.27	2.67	1.52	1.837	2.119	0.308350896322176	0.362779483059131	1.50457038391225E-17	0.170566190602959	0.775297640004946	0.958956615096849	0.703189639676216	0.915193515309545	20541.0495723262	79596.1275426221		2657106.34177438	3398147.96764637	1365787.73467607	1578272.63307431	1205878.60177515	1625778.79640944	7998382.13678965	8274900.61088866	5600614.51816097	3209012.09868788	1154237.54308251	3609675.59166937
Q68FD5	Clathrin heavy chain 1 [OS=Mus musculus]	180.117	32	43	363	43	1675	191.4	cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes	plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component	nucleic acid binding activity;other molecular function	67300	ENSMUSG00000047126	Cltc	mmu:67300; Q68FD5	IL-7 signaling pathway; Kit receptor signaling pathway	MHC class II antigen presentation; Recycling pathway of L1; Cargo recognition for clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis; LDL clearance; Retrograde neurotrophin signalling; Formation of annular gap junctions; Lysosome Vesicle Biogenesis; WNT5A-dependent internalization of FZD4; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation; RHOU GTPase cycle; RHOV GTPase cycle	6.05	5.808	20	6.768	2.931	1.275	1.251	2.935	0.4248536990637	0.198232028950426	1.50457038391225E-17	0.413413145615294	0.688274955487563	0.840666598828607	0.946476383814868	0.835383236382767	19752.350121194		9410.067942265	2001079.20697008	2709198.63758679	1592899.41627153	1121542.74388673	1205380.43272811	1952895.490984	7620271.96644723	6531411.29627789	6339405.19264676	2211269.42731124	1288866.59437226	2734753.66820203
P02469	Laminin subunit beta-1 [OS=Mus musculus]	179.863	27	40	429	39	1786	197	cell adhesion;cell organization and biogenesis;developmental processes;other biological processes	non-structural extracellular;extracellular matrix;nucleus;other cell component	signal transduction activity or receptor binding;extracellular structural activity;other molecular function	16777	ENSMUSG00000002900	Lamb1	E9PXZ9; P02469	Focal adhesion: PI3K-Akt-mTOR signaling pathway; Inflammatory response pathway; Alpha 6 beta 4 integrin signaling pathway; Focal adhesion		9.979	4.434	6.526	2.693	0.537	1.97	0.475	2.435	0.205801242418232	0.341417478664423	0.526489846375643	0.891178501081124	0.269583968882479	0.900334730044572	0.356773085915651	0.98779298590131	1.07332672254E7	1.09845016908001E7	9663847.07936098	1.70142446901215E7	1.73820787777271E7	2.08268192848537E7	1.23074043806854E7	1.3842748821146E7	1.68288599063313E7	1.20697658178524E7	1.33872705970957E7	9031275.37365186	2.12878061302996E7	2.54341447554609E7	1.6513199650281E7
Q01853	Transitional endoplasmic reticulum ATPase [OS=Mus musculus]	179.055	52	32	411	32	806	89.3	cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;other biological processes	other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component	signal transduction activity or receptor binding;enzyme regulator activity;other molecular function	269523	ENSMUSG00000028452	Vcp	mmu:269523; Q01853; Q3TFH9; Q3TIM2; Q3TXN9; Q6PI18; Q8BSR6; Q8CEG4	IL-9 signaling pathway	RHOH GTPase cycle; Neutrophil degranulation; Protein methylation; Ovarian tumor domain proteases; Neddylation; ABC-family proteins mediated transport; Translesion Synthesis by POLH; Hedgehog ligand biogenesis; KEAP1-NFE2L2 pathway; HSF1 activation; N-glycan trimming in the ER and Calnexin/Calreticulin cycle; Josephin domain DUBs	1.775	2.885	1.782	1.945	1.345	2.036	0.893	3.238	0.915230778358139	0.645007535999596	0.808626104853287	0.953867932777128	0.953038161729767	0.877818946381645	0.901149690306505	0.737824045087029	462345.280919521	876653.458620268	526426.850526767	1.01571081063743E7	9889323.38925712	7942233.31155878	4702185.44070802	4580279.55870278	6732778.24078372	1.50535993864462E7	1.350776734351E7	9751498.62422888	4128956.06599177	3881002.94215154	5380991.32313934
Q03350	Thrombospondin-2 [OS=Mus musculus]	178.303	35	30	328	29	1172	129.8	cell adhesion;other biological processes	non-structural extracellular;extracellular matrix;other cell component	other molecular function	21826	ENSMUSG00000023885	Thbs2	mmu:21826; Q03350; Q8CG21	Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion	Signaling by PDGF; O-glycosylation of TSR domain-containing proteins	0.722	1.325	0.917	0.852	0.905	1.968	0.612	3.033	0.425958502904743	0.861805134687803	0.49027994509233	0.535702081245677	0.792896707923278	0.900334730044572	0.620448351319483	0.80954066750699	2258622.92192986	2382783.54746756	1148078.18193404	1.31796330485542E7	1.5104624453426E7	5024405.63191042	7531099.32555027	7013388.1367688	7773703.92822199	1.11743686938308E7	1.16923792648853E7	8892616.7561804	4798999.04450137	2163159.37338424	5673668.48605754
Q80YX1	Tenascin [OS=Mus musculus]	175.9	28	43	191	43	2110	231.7	cell adhesion;cell-cell signaling;cell organization and biogenesis;stress response;developmental processes;other biological processes	non-structural extracellular;extracellular matrix;other cell component	signal transduction activity or receptor binding;other molecular function	21923	ENSMUSG00000028364	Tnc	mmu:21923; Q64706; Q80YX1; Q80YX2	Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion	Integrin cell surface interactions; ECM proteoglycans; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation	13.594	2.194	1.128	0.769	0.051	7.209	0.207	1.299	0.117980756369098	0.827773046590747	0.560799429150649	0.474732236495646	1.08858887903907E-8	0.00280630917527262	0.00972980877962454	0.46732263590517	11007.0641239407	22426.4186578027	29153.7668969926	1.62969685459921E7	1.53776908456905E7	4644794.12302626	1608421.63729791	1232799.46655266	1507622.18059477	244493.865771831	206768.885305398	181767.385360463	119126.026959952	48104.5148614081	121500.029653831
Q61147	Ceruloplasmin [OS=Mus musculus]	175.43	36	33	380	33	1061	121.1	cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes	non-structural extracellular	other molecular function	12870	ENSMUSG00000003617	Cp	mmu:12870; Q61147; Q6P5C8		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Iron uptake and transport; Metal ion SLC transporters	20	11.915	12.922	6.069	0.422	1.96	0.402	1.911	1.65082956259427E-17	0.0286042496128814	0.232756100865398	0.470567140616547	0.114472406028442	0.902824569867946	0.217345018530886	0.830251457557488	174325.913751449	58856.3090021062	115033.849364799	9557281.19120236	1.04767827169696E7	8762702.67228452	5461844.00566682	4018732.98956624	4629071.77649001	4355240.25919752	3723693.63350954	2684226.57769155	1556963.66647869	1720243.51649846	1992732.45731179
Q3UQ28	Peroxidasin homolog [OS=Mus musculus]	173.636	35	39	366	39	1475	165	cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes	extracellular matrix;ER/Golgi;other cell component	extracellular structural activity;other molecular function	69675	ENSMUSG00000020674	Pxdn	A4FU83; E9QNQ9; mmu:69675; Q3UQ28		Crosslinking of collagen fibrils	13.369	5.796	7.187	4.304	0.633	2.558	0.614	2.684	0.121749369203589	0.199060935853007	0.481687712882875	0.64860195920101	0.414844709855988	0.680311384167738	0.622521206052951	0.910753558746772	41306.9360165718	84058.3874627107	31201.070658041	9910595.89492489	1.28240532958945E7	7690537.3381544	3188445.14026578	3418561.86158515	3797799.58981602	6834484.53714744	5848987.74573488	4912888.48741006	1858779.55214279	743355.386480967	2642059.33003837
Q61316	Heat shock 70 kDa protein 4 [OS=Mus musculus]	169.044	48	31	300	31	841	94.1	protein metabolism;other metabolic processes	other cell component	other molecular function			Hspa4	Q61316		Regulation of HSF1-mediated heat shock response	3.829	1.513	4.49	1.286	1.217	1.907	0.903	2.909	0.675982462193546	0.947627746595709	0.704651587991194	0.760498481134506	0.937908804051419	0.922660568001848	0.905946265571965	0.842404289073844	22434.4697799145	118934.685179003	13120.5332518918	3090247.7626811	3632683.19217962	4934376.07998548	1752659.26658268	1094548.72984359	2299362.24833368	6254897.5603188	4282912.67963475	3832568.37667092	1209098.21921722	1139246.15986255	2002609.64313824
Cont_P02533	Keratin, type I cytoskeletal 14 OS=Homo sapiens OX=9606 GN=KRT14 PE=1 SV=4	164.831	58	26	684	9	472	51.5	cell organization and biogenesis;other biological processes	plasma membrane;cytosol;cytoskeleton;nucleus;other cell component	cytoskeletal activity;other molecular function	3861	ENSG00000186847	KRT14	hsa:3861; P02533; Q14715; Q53XY3; Q9BUE3; Q9UBN2; Q9UBN3; Q9UCY4	Corticotropin-releasing hormone signaling	Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin; Developmental Lineage of Mammary Gland Myoepithelial Cells; Type I hemidesmosome assembly	1.494	1.366	1.328	2.74	0.843	1.136	1.961	0.518	0.821333803243143	0.880930298968675	0.666244110962191	0.887279041944908	0.735573385767802	0.728871118050286	0.645534074006669	1.76226512549596E-4	6033554.14310828	6671959.15781397	7782964.06135275	8837829.92566611	1.15627425945257E7	9278023.72116937	1.41062299354562E7	8950994.20838312	7841743.81261716	1.15454726530467E7	7260451.91646668	9574113.2223773	5.39893889957522E7	2.05703168301172E7	1.34402077310531E7
P11499	Heat shock protein HSP 90-beta [OS=Mus musculus]	164.719	50	29	532	19	724	83.2	cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes	non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component	enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function	15516	ENSMUSG00000023944	Hsp90ab1	mmu:15516; O89078; P11499; Q3UIQ7	Focal adhesion: PI3K-Akt-mTOR signaling pathway	Neutrophil degranulation; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of actin dynamics for phagocytic cup formation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Attenuation phase; Estrogen-dependent gene expression; Sema3A PAK dependent Axon repulsion; Aryl hydrocarbon receptor signalling; DDX58/IFIH1-mediated induction of interferon-alpha/beta; HSF1 activation; RHOBTB2 GTPase cycle; The NLRP3 inflammasome	20	20	20	20	1.344	3.198	1.054	3.873	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.952333191127893	0.385192173946943	0.975071223710592	0.476079393565723	221410.585638305	129165.68527882	147525.692220339	3.34627647115336E7	3.61961534999558E7	2.61391308788083E7	9541203.16877468	9273367.56835581	1.36082703259873E7	4.57710434253974E7	4.37708354854306E7	3.73056416942256E7	1.17622035416132E7	7437513.65495311	1.56244060515822E7
Q9JKF1	Ras GTPase-activating-like protein IQGAP1 [OS=Mus musculus]	163.926	28	36	250	36	1657	188.6	cell organization and biogenesis;developmental processes;signal transduction;other biological processes	plasma membrane;other membranes;cytoskeleton;nucleus;other cell component	enzyme regulator activity;other molecular function	29875	ENSMUSG00000030536	Iqgap1	G3UW45; mmu:29875; Q9JKF1	G13 signaling pathway; Regulation of actin cytoskeleton	RHO GTPases activate IQGAPs; Neutrophil degranulation; RAC1 GTPase cycle; RAC2 GTPase cycle; RHOA GTPase cycle; MAP2K and MAPK activation; RHOQ GTPase cycle; RHOC GTPase cycle; RHOU GTPase cycle; RHOV GTPase cycle; Nephrin family interactions	2.389	1.188	3.792	2.098	2.451	1.85	1.692	2.634	0.930229675308081	0.794460986683881	0.787568130909409	0.991639536226218	0.830676695521175	0.941920360687835	0.777195460870953	0.924682711624237	49243.316732893	68725.418758499		969026.209101501	1404075.03080168	833592.785314498	204266.486982725	334218.990287697	455010.844725875	4213732.69874793	3933999.53801573	3238797.72524118	860307.289081776	503563.00444482	1468565.36197421
P52480	Pyruvate kinase PKM [OS=Mus musculus]	163.393	62	27	442	27	531	57.8	cell organization and biogenesis;other metabolic processes;other biological processes	cytosol;ER/Golgi;nucleus;other cell component	nucleic acid binding activity;kinase activity;other molecular function	18746	ENSMUSG00000032294	Pkm	mmu:18746; P52480; Q3TBV8; Q3TBW5; Q3TC59; Q3U1X3; Q3U5P6; Q4VC20; Q64484; Q91YI8; Q9CWB1	Glycolysis and gluconeogenesis; Purine metabolism	Neutrophil degranulation; Pyruvate metabolism; Glycolysis; Regulation of pyruvate metabolism	20	20	20	20	1.91	1.562	1.218	2.517	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.938859506774495	0.972868731003358	0.958705855138011	0.959522188921769	312569.127047718	79336.1029165598	280190.614862653	2.13357824001936E7	1.96436562290884E7	9081648.29120601	1.01259485831113E7	9467201.29798786	1.55257573035923E7	3.31547939620584E7	3.43565739025104E7	2.75852274417617E7	1.43901632993649E7	7722776.69094361	1.86748082798887E7
P63017	Heat shock cognate 71 kDa protein [OS=Mus musculus]	161.557	53	28	572	23	646	70.8	cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;other biological processes	non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component	signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function	15481	ENSMUSG00000015656	Hspa8	mmu:15481; P08109; P12225; P63017; Q3U6R0; Q3U764; Q3U7D7; Q3U7E2; Q3U9B4; Q3U9G0; Q3UGM0; Q5FWJ6; Q62373; Q62374; Q62375; Q6NZD0	Mapk signaling pathway; Exercise-induced circadian regulation	Neutrophil degranulation; mRNA Splicing - Major Pathway; Regulation of HSF1-mediated heat shock response; PKR-mediated signaling; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis; Attenuation phase; Lysosome Vesicle Biogenesis; GABA synthesis, release, reuptake and degradation; AUF1 (hnRNP D0) binds and destabilizes mRNA; Protein methylation	20	20	20	20	1.586	1.511	0.674	3.559	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.987939278265184	0.953011140807089	0.709593139419252	0.587315224195015	247063.168316828	221267.865667273	228333.997143376	2.34302361722569E7	1.91610816116977E7	2.44529780700925E7	1.52458610795295E7	1.21057626921531E7	1.98188188374949E7	4.35786305197153E7	3.523488629513E7	2.44125225303247E7	1.30838270231471E7	9679200.3009757	1.32405397257932E7
Q9JHU4	Cytoplasmic dynein 1 heavy chain 1 [OS=Mus musculus]	161.009	14	55	258	55	4644	531.7	cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes	cytoskeleton;other cell component	cytoskeletal activity;other molecular function	13424	ENSMUSG00000018707	Dync1h1	E9QM71; mmu:13424; Q9JHU4		MHC class II antigen presentation; Neutrophil degranulation; Separation of Sister Chromatids; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; COPI-mediated anterograde transport; Recruitment of NuMA to mitotic centrosomes; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-independent Golgi-to-ER retrograde traffic; Aggrephagy; Anchoring of the basal body to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; AURKA Activation by TPX2	0.975	1.246	1.606	1.856	2.687	1.626	1.854	2.534	0.591873375996003	0.826895204418257	0.758743075163871	0.936818656936794	0.771389136401717	0.987352798667733	0.695927216301667	0.953305976192702	224060.75101347	288932.991027563	370866.333925136	1035717.43113769	1898525.78207622	892363.147243056	298543.620628635	395801.785314415	659710.172961205	5741364.17159479	5412980.23144293	4332188.15134028	1541170.38578568	1219184.02821873	1626625.47525789
Q99K41	EMILIN-1 [OS=Mus musculus]	157.011	31	21	244	21	1017	107.5	cell adhesion;cell organization and biogenesis;developmental processes;other biological processes	non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component	signal transduction activity or receptor binding;extracellular structural activity;other molecular function	100952	ENSMUSG00000029163	Emilin1	mmu:100952; Q99K41		Molecules associated with elastic fibres	20	20	20	20	0.468	2.622	0.322	3.831	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.169879542413978	0.64186124184599	0.0921665663508908	0.491906845171331				6287128.66260445	6034831.78772075	4173278.84836641	1744058.35010072	1513530.29654839	1757558.94039384	2698540.13579468	2559754.7470142	1836473.80243277	371444.218276851	286714.652107864	495091.120602366
Q61879	Myosin-10 [OS=Mus musculus]	146	19	31	236	20	1976	228.9	cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes	plasma membrane;other membranes;cytosol;cytoskeleton;other cell component	cytoskeletal activity;nucleic acid binding activity;other molecular function	77579	ENSMUSG00000020900	Myh10	mmu:77579; Q5SV63; Q61879	Regulation of actin cytoskeleton	RHO GTPases activate PAKs	1.209	0.791	1.357	2.489	1.52	1.681	1.232	2.649	0.705689538076567	0.506231596289679	0.676239752697828	0.933545599871938	0.996007724449986	0.990096171400123	0.953146340313072	0.921444667457376	132922.802732814	81410.1821075416	155803.703539863	578601.376274227	569525.366217458	228469.06472958	249877.75631	195698.454667987	352494.602688902	1222751.03080206	1020719.46631895	1025108.65415173	659882.564109888	489393.525760184	539451.948957579
Cont_P00761	Trypsin OS=Sus scrofa OX=9823 PE=1 SV=1	143.502	62	11	3859	10	231	24.4	protein metabolism;other biological processes	non-structural extracellular	other molecular function							0.498	0.443	0.689	0.579	0.942	1.146	1.203	1.114	0.254996071775817	0.172153475402034	0.357784551188889	0.34040294575649	0.822223648478518	0.740968241512781	0.960577895552113	0.148582186670595	5.17896971017178E9	5.13317471139103E9	7.27761160813741E9	2.70973552724487E9	1.73168232498425E9	2.0962236592694E9	3.08554430734093E9	3.85764460784296E9	3.06099934235171E9	1.42194297351806E9	1.8379662886425E9	3.81973460995747E9	5.23567407489624E9	5.3849654871275E9	2.81761370832162E9
P20029	Endoplasmic reticulum chaperone BiP [OS=Mus musculus]	142.966	48	25	434	23	655	72.4	protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes	non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component	enzyme regulator activity;translation activity;other molecular function	14828	ENSMUSG00000026864	Hspa5	mmu:14828; O35642; P20029; Q3UFF2; Q61630	Mapk signaling pathway	Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Regulation of HSF1-mediated heat shock response	20	20	20	20	2.034	1.181	1.138	2.043	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.916283277860523	0.769590657123576	0.985707795620743	0.888702680095366				7850142.93480902	7648809.53150357	9169945.31743656	7535475.80605118	5802650.52918468	8839942.11003441	1.89485602512479E7	1.6006905998567E7	1.24118184289709E7	8533209.24248049	7216046.0503345	9459779.49149077
Cont_P13647	Keratin, type II cytoskeletal 5 OS=Homo sapiens OX=9606 GN=KRT5 PE=1 SV=3	142.395	51	34	500	20	590	62.3	cell organization and biogenesis;other biological processes	cytosol;cytoskeleton;other cell component	bone, tooth or skin structural activity;cytoskeletal activity;other molecular function	3852	ENSG00000186081	KRT5	hsa:3852; P13647; Q6PI71; Q6UBJ0; Q8TA91		Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin; Developmental Lineage of Mammary Stem Cells; Developmental Lineage of Mammary Gland Myoepithelial Cells; Type I hemidesmosome assembly	1.412	1.296	1.45	3.637	1.063	1.124	2.854	0.442	0.786915923361782	0.847457711018997	0.707170943024881	0.746833150482801	0.873755746039336	0.714156118974909	0.2733017775894	2.49132633766938E-5	5120503.46953844	5171426.92187225	6553368.21772984	9669299.63907403	1.1127930529353E7	9127716.50969809	9513581.76230213	7584977.17814252	6506980.60696686	1.59683716443188E7	1.28154121523541E7	1.32126695164861E7	5.39600661696836E7	1.8678004759752E7	1.36191738010446E7
Cont_P08779	Keratin, type I cytoskeletal 16 OS=Homo sapiens OX=9606 GN=KRT16 PE=1 SV=4	140.751	54	25	569	12	473	51.2	cell organization and biogenesis;stress response;other biological processes	plasma membrane;cytosol;cytoskeleton	cytoskeletal activity	3868	ENSG00000186832	KRT16	A8K488; hsa:3868; P08779; P30654; Q16402; Q9UBG8	Vitamin D receptor pathway	Formation of the cornified envelope	1.858	1.769	1.616	2.725	0.945	0.933	1.398	0.544	0.941324060398065	0.961351301268194	0.761460393544015	0.887279041944908	0.82543231800733	0.493923182294169	0.895302208460818	3.1065941501805E-4	1047544.82178002	1389728.97312405	1389730.63830375	1501449.09449526	2307427.01338473	2939547.44501319	7196685.12946156	1715910.61220057	2812173.28112121	4331979.12309994	1639569.64130669	1737373.70058763	9547147.41410007	4434008.92515372	2223613.02167429
Cont_P02465	Collagen alpha-2(I) chain OS=Bos taurus OX=9913 GN=COL1A2 PE=1 SV=2	139.99	18	19	445	3	1364	129		non-structural extracellular;extracellular matrix	extracellular structural activity;other molecular function	282188	ENSBTAG00000013472	COL1A2	A6QP13; bta:282188; O62649; P02465	Inflammatory response pathway; Focal adhesion	Fibronectin matrix formation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Collagen degradation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; Collagen chain trimerization; GPVI-mediated activation cascade; Platelet Aggregation (Plug Formation); Platelet Adhesion to exposed collagen; GP1b-IX-V activation signalling	0.802	1.357	0.812	0.776	0.839	0.601	0.572	1.046	0.483779141493222	0.876027096029978	0.421836754550416	0.488872343346086	0.731850662833984	0.076245756040016	0.549852418071669	0.432748651973214	80849.8235508145	93725.5578519836	35755.9745173747	170240.553800628	153570.468872413	167384.810476394	78292.6458688874	70345.2867467554	108688.239366299	65032.7123193958	48396.6073357386	51482.0177898574	32903.9376967684	51011.1923790395	62191.0072542807
Cont_P12763	Alpha-2-HS-glycoprotein OS=Bos taurus OX=9913 GN=AHSG PE=1 SV=2	132.772	50	16	1191	16	359	38.4	stress response;other biological processes	non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component	enzyme regulator activity	280988		AHSG	A6QLF7; bta:280988; P12763		Neutrophil degranulation; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation	0.943	1.184	1.213	0.612	1.313	0.781	0.463	2.11	0.573667790345329	0.793013134473823	0.624272910267193	0.36488675645736	0.946568086066385	0.268930374946741	0.335956814949331	0.913214993335179	6.75081036645858E8	9.56771805796805E8	4.32862555462728E8	6.04790296716478E8	6.42824998486085E8	6.76887564991134E8	8.54466282868744E8	8.4303805016043E8	9.16216503216691E8	7.41908408260606E8	7.48114705273509E8	6.29285280642112E8	3.25834950231514E8	3.42283489676807E8	6.64083343401506E8
P07901	Heat shock protein HSP 90-alpha [OS=Mus musculus]	132.382	43	25	402	16	733	84.7	cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes	plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component	signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function	15519	ENSMUSG00000021270	Hsp90aa1	mmu:15519; P07901	EBV LMP1 signaling; Focal adhesion: PI3K-Akt-mTOR signaling pathway; IL-6 signaling pathway; IL-2 signaling pathway	Regulation of necroptotic cell death; Recruitment of NuMA to mitotic centrosomes; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of actin dynamics for phagocytic cup formation; Neutrophil degranulation; Downregulation of ERBB2 signaling; Anchoring of the basal body to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; AURKA Activation by TPX2; Extra-nuclear estrogen signaling; Attenuation phase; Estrogen-dependent gene expression; Sema3A PAK dependent Axon repulsion; VEGFR2 mediated vascular permeability; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation; DDX58/IFIH1-mediated induction of interferon-alpha/beta; eNOS activation; HSF1 activation; RHOBTB2 GTPase cycle; Drug-mediated inhibition of ERBB2 signaling	20	0.796	20	9.684	1.447	2.287	1.041	3.222	1.65082956259427E-17	0.508730894200713	1.50457038391225E-17	0.251664970734015	0.974827674952665	0.788764875934969	0.968364585136618	0.745600589176001	51071.3130902855	169244.190500369	193833.457176882	3826029.08230807	4600695.96516161	3479662.10980986	1533159.7098775	1700635.66665037	1768278.53880507	6471421.59388824	6122550.53993506	5450079.38924241	1704183.40484156	900341.190737514	2215799.13247972
Q02819	Nucleobindin-1 [OS=Mus musculus]	131.152	51	21	299	21	459	53.4	signal transduction	non-structural extracellular;other membranes;ER/Golgi	enzyme regulator activity;nucleic acid binding activity;other molecular function	18220	ENSMUSG00000030824	Nucb1	mmu:18220; Q02819; Q3TU42; Q9CWA1; Q9D8J4; Q9DBL3		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation	20	20	20	14.326	0.375	3.321	0.498	2.52	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	0.130903496983571	0.0679830640731695	0.340647566778883	0.397987186613988	0.958122559708965	41072.7931792495		20198.6046706008	1.70846710933602E7	1.97547416617741E7	2.08807433533847E7	5757191.6972993	4828078.95450858	5895038.38978249	7136546.74332753	7387752.88718417	5120327.81590923	2637872.59598673	1130733.36645935	3369667.63744922
Q91V92	ATP-citrate synthase [OS=Mus musculus]	129.973	32	28	237	28	1091	119.7	other metabolic processes	cytosol	other molecular function	104112	ENSMUSG00000020917	Acly	mmu:104112; Q91V92	Fatty acid biosynthesis	Neutrophil degranulation; Fatty acyl-CoA biosynthesis	9.31	4.235	7.838	5.627	0.759	1.697	0.624	2.139	0.230775890814232	0.371468864113786	0.437429424171984	0.509570119936397	0.626059420687734	0.98558531112136	0.643183834410259	0.922580167429744	8856.99380706579	32765.2400642807	40990.0091117865	2382723.31982566	2481678.51703659	2154876.39410613	1256305.5375454	885993.369046538	1688459.92743218	2057502.05407172	1815562.79058184	1460220.9588277	594587.914542531	534991.757912276	802971.776166877
A2ASQ1	Agrin [OS=Mus musculus]	128.989	18	26	227	26	1950	207.4	cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes	non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cell component	signal transduction activity or receptor binding;other molecular function	11603	ENSMUSG00000041936	Agrn	A2ASP9; A2ASQ0; A2ASQ1; B2RWU1	Primary focal segmental glomerulosclerosis (FSGS)	ECM proteoglycans; Retinoid metabolism and transport; Glycosaminoglycan-protein linkage region biosynthesis; HS-GAG biosynthesis; HS-GAG degradation; Formation of the dystrophin-glycoprotein complex (DGC)	20	20	20	20	0.661	1.77	0.657	1.948	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.460727828548759	0.972791368602389	0.686318824668434	0.846971399004193				2612028.52511147	3116500.52541199	3328171.1398056	1818519.74579979	1551006.46226864	1715477.48863677	2313945.16119856	2044906.61336417	1778324.63596447	957812.214242183	632566.873707257	1496109.18442141
Q61508	Extracellular matrix protein 1 [OS=Mus musculus]	127.379	45	18	358	18	559	62.8	stress response;developmental processes;signal transduction;other biological processes	non-structural extracellular	signal transduction activity or receptor binding;other molecular function	13601	ENSMUSG00000028108	Ecm1	mmu:13601; Q3U5Q5; Q61508		Platelet degranulation	20	20	20	14.914	0.149	1.214	0.053	3.546	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	0.121600547823456	2.27890527565265E-4	0.795351011232032	1.51989274634622E-7	0.592370654746194	110159.96586707	68619.5270607555	45654.6843175291	5.6443097497098E7	7.11751205740166E7	5.82782830048746E7	5.1935854689884E7	4.50204039942893E7	5.70225374161979E7	1.27540105597053E7	1.25514774649527E7	8690203.83604475	3690111.31703252	2192350.97546663	4663417.73981907
Cont_P04259	Keratin, type II cytoskeletal 6B OS=Homo sapiens OX=9606 GN=KRT6B PE=1 SV=5	126.901	47	30	442	4	564	60	cell organization and biogenesis;other biological processes	cytosol;cytoskeleton	bone, tooth or skin structural activity;cytoskeletal activity	3854	ENSG00000185479	KRT6B	hsa:3854; P04259; P48669		Formation of the cornified envelope	1.588	2.045	1.606	3.292	1.017	0.828	1.287	0.641	0.857251372850113	0.868132360832926	0.758743075163871	0.801271130817871	0.854305439376382	0.340133476321195	0.937453377971347	0.00123883404563536	267279.779286483	355493.362381868	274137.281616349	326989.588402741	585438.697100962	617622.938974811	2390973.53573307	430931.486741926	646270.614315847	1869779.42318807	346417.77494154	348508.009299423	1653754.7898307	1155463.67620058	538093.594898596
P17182	Alpha-enolase [OS=Mus musculus]	126.804	60	19	244	16	434	47.1	other metabolic processes;developmental processes;other biological processes	plasma membrane;other membranes;cytosol;other cell component	nucleic acid binding activity;other molecular function	13806; 433182	ENSMUSG00000059040; ENSMUSG00000063524	Eno1	mmu:13806; mmu:433182; P17182; Q99KT7; Q9DCY7	Glycolysis and gluconeogenesis		20	20	20	20	2.837	1.204	1.518	2.329	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.720832939248489	0.789540446904924	0.858218537342417	0.989544231571828	31098.019126098	70318.9502605952	40658.6319347469	1.28655809626545E7	1.34726279447959E7	7101469.5445256	9089751.86845938	7552189.93174957	1.17772011823713E7	3.50544676757808E7	2.99447661492486E7	2.18255690502528E7	1.30151947674988E7	1.11532480577619E7	1.75489228796712E7
P08113	Endoplasmin [OS=Mus musculus]	126.346	39	26	329	25	802	92.4	cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes	non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cell component	signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function	22027	ENSMUSG00000020048	Hsp90b1	mmu:22027; P08113; P11427	Focal adhesion: PI3K-Akt-mTOR signaling pathway; Hypoxia-dependent self-renewal of myoblasts	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Scavenging by Class A Receptors; Trafficking and processing of endosomal TLR; Interleukin-4 and Interleukin-13 signaling	14.282	15.982	20	11.019	2.346	1.275	1.501	2.064	0.107476768049312	0.0104456807471941	1.50457038391225E-17	0.205304099107124	0.854305439376382	0.840785133352029	0.866766165039268	0.896996950298791	75656.6139115948	52183.5314261123	29905.9702816436	5932785.14172209	5786569.94317903	3299962.37110113	3817668.17887426	3366255.7650389	4907428.60350699	1.47606948013545E7	1.21020755462977E7	1.0441016038914E7	6464144.86133097	3792376.91369813	7854793.82920015
P58252	Elongation factor 2 [OS=Mus musculus]	126.048	37	31	378	30	858	95.3	cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes	plasma membrane;other membranes;cytosol;translational apparatus;other cell component	cytoskeletal activity;translation activity;nucleic acid binding activity;other molecular function	13629	ENSMUSG00000034994	Eef2	mmu:13629; P58252; Q544E4	Translation factors	Neutrophil degranulation; Protein methylation; Peptide chain elongation; Synthesis of diphthamide-EEF2	7.873	5.944	7.322	3.019	1.183	1.75	0.816	2.548	0.299809054080284	0.188334321166369	0.471929633209224	0.84258396038376	0.922179983282929	0.97504218639442	0.866546043492515	0.950878070645738	275529.241689771	247076.7728808	166294.142173825	1.22498155967913E7	1.26488626480754E7	6800245.14611723	5717562.35282925	5172569.64432748	8352282.82529915	1.55667000517401E7	1.33925688878402E7	1.02378508629272E7	5184391.52691505	2972661.18095993	6421886.97759523
Cont_P02538	Keratin, type II cytoskeletal 6A OS=Homo sapiens OX=9606 GN=KRT6A PE=1 SV=3	123.757	47	30	454	3	564	60	cell organization and biogenesis;stress response;other biological processes	cytosol;cytoskeleton	bone, tooth or skin structural activity;cytoskeletal activity	3853	ENSG00000205420	KRT6A	A4QPC1; hsa:3853; P02538; P48667; Q08AR4; Q6NT67; Q96CL4	Ectoderm differentiation; Ectoderm differentiation; Pancreatic cancer subtypes	Formation of the cornified envelope	1.699	1.759	1.562	3.017	0.903	0.993	1.821	0.574	0.892533464536408	0.964633336683333	0.745886066139481	0.84258396038376	0.792564971776066	0.574739141583974	0.709593139419252	5.66461038960431E-4	2017098.82314832	2171650.09464557	2359880.73116726	2825309.68904382	4320098.03084773	4192074.59940388	8075888.41129776	2685265.07688442	3594101.84504227	5878699.8667026	3215829.01184206	2854010.96069105	1.30998597349634E7	8158147.16608847	4198498.19802621
P97298	Pigment epithelium-derived factor [OS=Mus musculus]	123.502	47	16	346	12	417	46.2	cell cycle OR cell proliferation;developmental processes;other biological processes	non-structural extracellular;extracellular matrix;other cell component	enzyme regulator activity	20317	ENSMUSG00000000753	Serpinf1	mmu:20317; O70629; O88691; P97298			20	5.45	7.9	3.48	0.255	3.903	0.445	2.758	1.65082956259427E-17	0.227296093012204	0.434748506750565	0.770205086382264	0.00901230529014985	0.174886032348437	0.300753028734261	0.891044455497809	554016.1710638	470705.490372182	363015.858993357	5.24905837082578E7	7.20656975211191E7	8.90978835263609E7	1.55195541438312E7	1.33807646088142E7	1.504676823338E7	1.63245792137601E7	1.5700230598517E7	1.5246806329463E7	4897006.93274029	3869051.7420588	8996988.40278734
Q70E20	Sushi, nidogen and EGF-like domain-containing protein 1 [OS=Mus musculus]	122.942	19	22	287	22	1403	151.5	cell adhesion	non-structural extracellular;extracellular matrix	other molecular function	208777		Sned1	A6H6I3; mmu:208777; Q70E20; Q810H2; Q8BMD9			20	20	20	20	2.169	2.063	1.623	2.787	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.889058672589993	0.869908412860824	0.817293288705596	0.880760468933162	62940.5062355012	25184.2741656831	25459.8187779288	7879183.70581794	8304827.25748066	2617617.70526214	3110990.0320528	3263544.92621848	3507274.08693078	1.72480350493842E7	1.48489121993504E7	1.05732378776404E7	5373074.41423662	2537287.1447922	7075122.99473268
P13020	Gelsolin [OS=Mus musculus]	122.934	35	22	377	9	780	85.9	cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes	non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component	cytoskeletal activity;other molecular function	227753	ENSMUSG00000026879	Gsn	mmu:227753; P13020; Q3UPB1; Q8R590	Regulation of actin cytoskeleton	Neutrophil degranulation; Caspase-mediated cleavage of cytoskeletal proteins	5.883	4.057	14.912	7.221	3.038	1.646	1.821	3.103	0.440427841758307	0.396306424610341	0.186266168629733	0.379422692457324	0.65414435708462	0.994546642862744	0.709593139419252	0.793590033024783	1154075.61374729	1486973.5078743	778278.604931373	1.0611315000974E7	9755419.92114226	9110194.21443976	6039243.17546894	5549542.61366164	7725308.54354706	3.63344365935893E7	2.77403609084757E7	2.33574049877416E7	1.03453705657478E7	8417203.0170929	1.43392014575414E7
Q61398	Procollagen C-endopeptidase enhancer 1 [OS=Mus musculus]	120.4	40	14	323	14	468	50.1	protein metabolism;other biological processes		enzyme regulator activity;other molecular function	18542	ENSMUSG00000029718	Pcolce	mmu:18542; O35113; Q61398	mRNA processing	Collagen biosynthesis and modifying enzymes; Crosslinking of collagen fibrils	20	20	16.934	8.868	0.439	1.204	0.32	1.719	1.65082956259427E-17	1.8644578313253E-17	0.151224536345852	0.288320039261486	0.133905327763598	0.789540446904924	0.0895861566882082	0.711902858921665	55825.2363051742	84655.3590880939	113029.200120433	3.10244208090572E7	2.97623271730106E7	2.79757713270171E7	2.72578314339105E7	2.28908828526637E7	2.54654481194513E7	1.54882233602667E7	1.24902767859117E7	9636426.2851997	7984547.74798259	5125325.32901055	9907837.52014591
P26039	Talin-1 [OS=Mus musculus]	118.226	15	30	153	30	2541	269.7	cell adhesion;cell organization and biogenesis;signal transduction	plasma membrane;other membranes;cytosol;cytoskeleton;other cell component	signal transduction activity or receptor binding;cytoskeletal activity;other molecular function	21894	ENSMUSG00000028465	Tln1	A2AIM8; mmu:21894; P26039; Q8VEF0	Primary focal segmental glomerulosclerosis (FSGS); Integrin-mediated cell adhesion; Focal adhesion	Platelet degranulation ; MAP2K and MAPK activation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; Smooth Muscle Contraction; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	2.278	1.64	4.713	1.234	2.379	2.301	1.474	3.671	0.958262397335385	0.994542145304377	0.680632778351053	0.738983404380581	0.850917681937748	0.783910800136359	0.87222702623065	0.535066779633529	137218.697336797	64798.4580467583	241653.653741064	580168.664793601	803244.58151111	320387.746187394	118081.406885094	124079.798936285	255551.526824265	2877993.84785898	2114900.66089323	1881659.61273992	234819.255172709	240671.449108311	385063.079961369
Q8BPB5	EGF-containing fibulin-like extracellular matrix protein 1 [OS=Mus musculus]	117.738	49	15	220	15	493	54.9	protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes	extracellular matrix	signal transduction activity or receptor binding;kinase activity;other molecular function	216616	ENSMUSG00000020467	Efemp1	mmu:216616; Q6Y3N6; Q8BPB5			20	20	20	7.265	0.542	1.608	0.36	2.306	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	0.376780684027729	0.278244203695445	0.983440558239231	0.145805028390539	0.982581944728745	15298.8221438323	19141.8575027524	55545.7753728227	7090020.68988726	8805500.10345141	5126350.07183034	4435222.67421531	4392813.74676133	4496081.41897935	4016966.57007158	3984703.05528875	2817881.79753384	1462163.85427198	682456.349264741	1966499.77195883
P09411	Phosphoglycerate kinase 1 [OS=Mus musculus]	116.462	57	18	287	18	417	44.5	protein metabolism;other metabolic processes;stress response;other biological processes	non-structural extracellular;other membranes;cytosol;mitochondrion;other cell component	kinase activity;other molecular function	18655	ENSMUSG00000062070	Pgk1	mmu:18655; P09411; Q3TPE6; Q3UKV8; Q5XJE7	Glycolysis and gluconeogenesis	Gluconeogenesis; Glycolysis	20	20	20	20	3.557	1.177	1.619	2.753	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.465126095372736	0.766862952867809	0.820281310709571	0.891044455497809	78089.4641074341	38741.0917691314	23421.0514741904	4316274.39280249	5023293.68471847	1442874.888393	2829873.33459098	2934698.045784	3868274.47312523	1.65254946701665E7	1.56270051770472E7	1.22346365889796E7	4530199.20599689	2315853.03926933	6654180.61411261
P27773	Protein disulfide-isomerase A3 [OS=Mus musculus]	115.891	55	23	291	23	505	56.6	cell adhesion;cell organization and biogenesis;stress response;signal transduction;other biological processes	non-structural extracellular;other membranes;ER/Golgi;other cell component	nucleic acid binding activity;other molecular function	14827	ENSMUSG00000027248	Pdia3	mmu:14827; P27773; Q3TEI9; Q3TIL2; Q3UZK8; Q8C2F4; Q99LF6		ER-Phagosome pathway; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Calnexin/calreticulin cycle	2.463	2.512	6.915	2.818	2.389	1.306	1.442	2.187	0.9135584231482	0.736536116100563	0.498293621965442	0.874168055361729	0.850917681937748	0.862063111456553	0.881496352314601	0.939046770372612	206281.038958907	253939.7116523	128510.108086966	6669793.66068216	7133803.24141356	5637352.69437344	5319375.96186612	3844376.07822282	6321729.00885173	1.83298906806341E7	1.50101054148645E7	1.26051366299531E7	6670485.36185494	6059857.55300524	8984695.03809976
P10107	Annexin A1 [OS=Mus musculus]	115.566	64	18	270	18	346	38.7	cell organization and biogenesis;stress response;transport;signal transduction;other biological processes	non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component	enzyme regulator activity;other molecular function	16952	ENSMUSG00000024659	Anxa1	mmu:16952; P10107	Spinal cord injury; Prostaglandin synthesis and regulation	G alpha (q) signalling events; G alpha (i) signalling events; Formyl peptide receptors bind formyl peptides and many other ligands	20	7.59	20	20	1.749	3.163	2.185	2.632	1.65082956259427E-17	0.105053536950499	1.50457038391225E-17	1.70336894001643E-17	0.954328834404239	0.401885831342676	0.529099828181544	0.924766494197286	13280.9290610842	9160.53166722029	4508.77124840677	5251880.61554565	6740833.31198439	6058745.6526555	1560362.01883491	1521121.84391776	1946127.08618424	1.11990207127477E7	1.0990927807692E7	1.0321301103113E7	4605609.45936174	3223846.7434476	4805492.80063037
Cont_Q2KJF1	Alpha-1B-glycoprotein OS=Bos taurus OX=9913 GN=A1BG PE=1 SV=1	115.502	48	14	224	14	503	53.5	signal transduction	non-structural extracellular;plasma membrane;other membranes		518955		A1BG	bta:518955; Q2KJF1		Platelet degranulation ; Neutrophil degranulation	1.057	0.967	1.256	0.607	1.203	1.109	0.599	2.051	0.635218461842139	0.655487072215252	0.641514600397631	0.360991986803736	0.932231143665149	0.696358249006924	0.601376052147163	0.891044455497809	1.12339445909494E7	1.09217008752481E7	5999938.28834399	7597724.26810103	8696294.29830821	1.02832125493257E7	1.08372253099689E7	9914324.88654618	8710997.51604168	1.11963323092602E7	9450705.94975847	1.03053408353504E7	5283853.74244175	5535891.07899516	9467766.08082133
Cont_Q3MHN5	Vitamin D-binding protein OS=Bos taurus OX=9913 GN=GC PE=2 SV=1	113.599	55	20	319	20	474	53.3	other metabolic processes;transport	non-structural extracellular;other cell component	transporter activity;cytoskeletal activity;other molecular function	530076		GC	bta:530076; Q3MHN5			0.903	1.209	1.108	0.763	1.298	0.671	0.583	1.405	0.549057967251154	0.804331105646976	0.579435037816218	0.479472599858427	0.946173787415917	0.139718417146003	0.570795727084329	0.421365656927814	1.55879441314789E7	1.53074066841615E7	7458694.29508707	1.04365108192777E7	1.20620475306269E7	8309099.82300618	1.67215053413279E7	1.54231806136738E7	1.57780518794517E7	1.6556516146824E7	1.52311500265876E7	1.20681229464E7	8133055.93664235	9478628.98672491	1.47438110125204E7
P17742	Peptidyl-prolyl cis-trans isomerase A [OS=Mus musculus]	113.527	60	9	369	9	164	18	cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes	non-structural extracellular;cytosol;nucleus;other cell component	signal transduction activity or receptor binding;other molecular function	268373	ENSMUSG00000071866	Ppia	mmu:268373; P17742; Q9CWJ5; Q9R137		Neutrophil degranulation; Basigin interactions	14.843	7.75	20	20	1.304	2.489	0.969	4.305	0.100219677394751	0.099382125133403	1.50457038391225E-17	1.70336894001643E-17	0.946239447314336	0.696358249006924	0.937453377971347	0.331144967260478	1.16891341386391E7	754837.409863468	4157779.88062054	2.9189343463191E7	2.94929696895869E7	4.96473559496876E7	1.04342545713823E7	8178713.43858634	1.18234267071803E7	4.91534751033825E7	4.2865019365108E7	4.61937263356195E7	9682919.1999608	7275434.18699702	1.51319991253865E7
Q69ZN7	Myoferlin [OS=Mus musculus]	112.647	22	36	227	36	2048	233.2	cell organization and biogenesis;other metabolic processes;stress response;other biological processes	plasma membrane;other membranes;nucleus	other molecular function	226101	ENSMUSG00000048612	Myof	mmu:226101; Q69ZN7; Q7TMG0; Q80V33; Q8BU64; Q8BU70; Q8BUC1; Q8BVY6; Q8C0D1; Q8R3B4			1.293	1.754	2.079	1.82	2.532	2.029	2.027	2.284	0.73657372909066	0.964709887217926	0.888974672311279	0.930955411749965	0.816275429153737	0.877818946381645	0.609903091678244	0.975029032316037	86000.3771233404	87234.2597428081	50456.7230101595	780930.944201502	985609.680593147	968573.73043394	296294.389327177	289800.794039455	380995.072506467	3324626.35891918	3238695.05806667	2634093.62813707	1025817.2029614	993761.586050851	1295229.11918404
P26041	Moesin [OS=Mus musculus]	112.068	47	28	353	19	577	67.7	cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes	plasma membrane;other membranes;cytosol;cytoskeleton;other cell component	signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function	17698	ENSMUSG00000031207	Msn	B1AX70; mmu:17698; P26041; Q3UL28; Q8BSN4	Regulation of actin cytoskeleton	Recycling pathway of L1	20	9.275	20	12.906	1.135	2.551	1.147	2.527	1.65082956259427E-17	0.0604972675946614	1.50457038391225E-17	0.157138696252226	0.910750689050232	0.682171843898269	0.97925982662951	0.954396180425051	3509434.20481405	4360753.56845675	2823311.97478394	1.57847182977139E7	1.58696599538661E7	1.95033967654703E7	8383545.44173348	7552431.53754312	1.1473115873696E7	2.43209045148915E7	1.7265255344344E7	1.55060800034236E7	7954804.76477835	1.24969658442338E7	1.31486313258361E7
P05064	Fructose-bisphosphate aldolase A [OS=Mus musculus]	112.015	66	18	261	18	364	39.3	cell organization and biogenesis;other metabolic processes;other biological processes	plasma membrane;other membranes;cytosol;cytoskeleton;other cell component	other molecular function	11674	ENSMUSG00000030695	Aldoa	mmu:11674; P05064	Glycolysis and gluconeogenesis	Platelet degranulation ; Neutrophil degranulation; Gluconeogenesis; Glycolysis	14.735	18.407	20	18.77	2.091	1.259	1.091	2.228	0.101571037453114	0.00616383846364181	1.50457038391225E-17	0.0771819601934254	0.907383519445145	0.828577692034317	0.988377544628277	0.953305976192702	36553.7681309936	18014.3910425567	11156.0078725057	5538849.24179232	5285372.3367409	3856062.26656154	4263443.39983126	3386915.16711964	5306808.16889341	1.24814165546298E7	1.09515793948855E7	8528808.13475854	4192052.54158905	4075248.71161469	5289067.55868911
B2RQC6	Multifunctional protein CAD [OS=Mus musculus]	111.853	18	32	111	32	2225	243.1	other metabolic processes;stress response;transport;developmental processes;other biological processes	cytosol;nucleus;other cell component	kinase activity;other molecular function	69719	ENSMUSG00000013629	Cad	B2RQC6; B7ZN27; mmu:69719	Mechanisms associated with pluripotency	Pyrimidine biosynthesis	3.69	2.77	4.876	2.316	0.581	1.776	0.743	1.7	0.69394578118832	0.6681512188534	0.666244110962191	0.963127218853016	0.340675523776301	0.968897093792999	0.798180783050573	0.621633895543644	55886.6384121637	12993.9975368397	34438.2113153553	1026045.60319635	1025412.85494839	821784.178770446	383358.762218724	322831.339780162	640190.890369534	516093.312619156	478923.162373783	363366.537093714	127462.003140709	110686.677299138	180829.981634378
Q8BND5	Sulfhydryl oxidase 1 [OS=Mus musculus]	111.186	35	22	242	22	748	82.7	cell organization and biogenesis;other biological processes	non-structural extracellular;other membranes;ER/Golgi	other molecular function	104009	ENSMUSG00000033684	Qsox1	mmu:104009; Q3TDY9; Q3TE19; Q3TR29; Q3UEL4; Q8BND5; Q8K041; Q9DBL6		Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Neutrophil degranulation	20	20	20	12.613	0.491	2.489	0.46	2.797	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	0.162753188077458	0.203109767081086	0.696358249006924	0.331332346840573	0.877612009404373	40119.4404166161		10016.9610840251	9134645.28263017	1.19624109837519E7	1.04856878607794E7	3750508.26959308	3765475.87858746	4032369.19900008	5503994.64256118	5774708.06447186	3841814.38132964	1498357.95430882	1169677.75963505	2786812.01379908

100

Accession	Description	Sum PEP Score	Coverage [%]	# Peptides	# PSMs	# Unique Peptides	# AAs	MW [kDa]	Biological Process	Cellular Component	Molecular Function	Entrez Gene ID	Ensembl Gene ID	Gene Symbol	Gene ID	WikiPathways	Reactome Pathways	Abundance Ratio Adj. P-Value: (LQ_16h) / FM	Abundance Ratio Adj. P-Value: (LQ_6h) / FM	Abundance Ratio Adj. P-Value: (SQ_16h) / FM	Abundance Ratio Adj. P-Value: (SQ_6h) / FM	Abundance Ratio Adj. P-Value: (SQ_16h) / (LQ_16h)	Abundance Ratio Adj. P-Value: (LQ_16h) / (LQ_6h)	Abundance Ratio Adj. P-Value: (SQ_6h) / (LQ_6h)	Abundance Ratio Adj. P-Value: (SQ_16h) / (SQ_6h)	Abundances (Normalized): F1: Sample, FM	Abundances (Normalized): F2: Sample, FM	Abundances (Normalized): F3: Sample, FM	FM_AVERAGE	Abundances (Normalized): F8: Sample, LQ_16h	Abundances (Normalized): F9: Sample, LQ_16h	Abundances (Normalized): F10: Sample, LQ_16h	LQ16h_AVERAGE	Abundances (Normalized): F4: Sample, LQ_6h	Abundances (Normalized): F5: Sample, LQ_6h	Abundances (Normalized): F6: Sample, LQ_6h	LQ6h_AVERAGE	Abundances (Normalized): F17: Sample, SQ_16h	Abundances (Normalized): F18: Sample, SQ_16h	Abundances (Normalized): F20: Sample, SQ_16h	SQ16h_AVERAGE	Abundances (Normalized): F15: Sample, SQ_6h	Abundances (Normalized): F16: Sample, SQ_6h	Abundances (Normalized): F14: Sample, SQ_6h	SQ6h_AVERAGE
P11276	Fibronectin [OS=Mus musculus]	867.353	58	95	2246	59	2477	272.4	cell adhesion;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes	non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi	signal transduction activity or receptor binding;enzyme regulator activity;other molecular function	14268	ENSMUSG00000026193	Fn1	G5E8B8; mmu:14268; P11276; Q61567; Q61568; Q61569; Q64233; Q80UI4	Focal adhesion: PI3K-Akt-mTOR signaling pathway; Inflammatory response pathway; Regulation of actin cytoskeleton; Comprehensive IL-17A signaling; Focal adhesion	ECM proteoglycans; Platelet degranulation ; Cell surface interactions at the vascular wall; Syndecan interactions; MAP2K and MAPK activation; Integrin cell surface interactions; Molecules associated with elastic fibres; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Fibronectin matrix formation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; Degradation of the extracellular matrix; Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells; MET activates PTK2 signaling; GPER1 signaling	0.0844744457809114	0.00584906503121538	1.50457038391225E-17	0.156115961659409	0.974036928885484	0.564710097967506	0.435823028559966	0.896613838854506	3.10111960161575E7	2.79853612635427E7	2.39278028537136E7	2.7641453377804603E7	2.27076161669542E8	2.29530848002383E8	1.81481696567249E8	2.12696235413058E8	2.13523563015262E8	1.92386583493888E8	2.00792310651879E8	2.022341523870097E8	3.0604731494329E8	2.72875123758133E8	2.45952285820886E8	2.7495824150743634E8	1.00071254189999E8	1.59531432686856E8	1.1928889459527E8	1.2629719382404166E8
P11087	Collagen alpha-1(I) chain [OS=Mus musculus]	797.017	79	75	1933	35	1453	137.9	cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes	non-structural extracellular;extracellular matrix;other cell component	extracellular structural activity;other molecular function	12842	ENSMUSG00000001506	Col1a1	mmu:12842; P11087; Q53WT0; Q60635; Q61367; Q61427; Q63919; Q6PCL3; Q810J9	Osteoblast signaling; Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Comprehensive IL-17A signaling; Focal adhesion	Cell surface interactions at the vascular wall; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ECM proteoglycans; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; GPVI-mediated activation cascade; GP1b-IX-V activation signalling; Platelet Adhesion to exposed collagen; Platelet Aggregation (Plug Formation); MET activates PTK2 signaling	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	1.58880673198775E-4	0.381922652011049	0.0629214061377862	0.655833157547641	703080.609341466	1047026.5902454	567207.050774397	772438.0834537543	6.12803341835757E8	6.28616080368892E8	5.37143706349406E8	5.92854376184685E8	2.20652487774689E8	1.86114398805651E8	2.17194307013081E8	2.0798706453114033E8	9.46570689754052E7	9.72166914362706E7	6.09758172025116E7	8.428319253806247E7	4.84358218594371E7	7.06441702532683E7	6.01286898886734E7	5.973622733379293E7
Q01149	Collagen alpha-2(I) chain [OS=Mus musculus]	773.662	80	66	1731	51	1372	129.5	cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes	non-structural extracellular;extracellular matrix;other cell component	extracellular structural activity;other molecular function	12843	ENSMUSG00000029661	Col1a2	mmu:12843; Q01149; Q8CGA5	Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Focal adhesion	Crosslinking of collagen fibrils; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; ECM proteoglycans; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; GPVI-mediated activation cascade; GP1b-IX-V activation signalling; Platelet Adhesion to exposed collagen; Platelet Aggregation (Plug Formation); MET activates PTK2 signaling	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.0150838661305169	0.862063111456553	0.0347692006632991	0.926292871155025	217896.573253055	102775.453905646	225868.955510701	182180.3275564673	3.82374533805921E8	3.80614155239716E8	2.79801552870279E8	3.475967473053053E8	1.73556920519588E8	1.55763113653521E8	1.89931753802048E8	1.7308392932505235E8	1.03217412397752E8	1.04517075360638E8	6.33578194684048E7	9.036410240893161E7	2.65479311979207E7	5.19818116295111E7	4.96147162399626E7	4.271481968913147E7
P08121	Collagen alpha-1(III) chain [OS=Mus musculus]	695.631	63	61	1789	51	1464	138.9	cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes	extracellular matrix;other cell component	signal transduction activity or receptor binding;extracellular structural activity;other molecular function	12825	ENSMUSG00000026043	Col3a1	mmu:12825; P08121; Q61429; Q9CRN7	Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Focal adhesion	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ECM proteoglycans; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; MET activates PTK2 signaling	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.00738207855214502	0.0413994480640273	0.394949139624895	0.976852696203657	619884.023482232	468692.52789102	275667.802679115	454748.1180174556	2.79020579584843E8	2.94236692581693E8	2.78582579285209E8	2.8394661715058166E8	6.51340156000414E7	5.70632610319163E7	6.62894421161806E7	6.282890624937943E7	7.54516142044654E7	7.68700494785543E7	4.61499837269909E7	6.6157215803336866E7	2.39448217703501E7	3.64849658219652E7	3.06665885804687E7	3.0365458724261332E7
Q9QXS1	Plectin [OS=Mus musculus]	659.702	46	182	1705	180	4691	533.9	cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes	plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component	cytoskeletal activity;other molecular function	18810	ENSMUSG00000022565	Plec	E9QN87; mmu:18810; Q6S384; Q6S389; Q6S394; Q9CS65; Q9QUT2; Q9QXQ8; Q9QXQ9; Q9QXR0; Q9QXR1; Q9QXR2; Q9QXR3; Q9QXR4; Q9QXR5; Q9QXR6; Q9QXR7; Q9QXR8; Q9QXR9; Q9QXS0; Q9QXS1; Q9QXS2; Q9QXS3	Alpha 6 beta 4 integrin signaling pathway; EGFR1 signaling pathway	Type I hemidesmosome assembly; Caspase-mediated cleavage of cytoskeletal proteins	0.481729871164266	0.714932595871944	0.336550483871782	0.572524806937582	0.850917681937748	0.532399788858771	0.702330308974487	0.520376293994664	307407.817065559	282192.990008148	340166.735457239	309922.514176982	1.95783440606639E7	1.89230076526173E7	1.15266683074569E7	1.6676006673579365E7	3962115.44279651	3474477.32513512	6361226.57462356	4599273.114185064	5.1842207663806E7	4.48709077668655E7	3.18339270889303E7	4.28490141732006E7	7604177.6415354	1.18325057871337E7	1.10137014373925E7	1.01501282886872E7
P08122	Collagen alpha-2(IV) chain [OS=Mus musculus]	526.992	64	69	1077	69	1707	167.2	RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes	non-structural extracellular;extracellular matrix	extracellular structural activity	12827	ENSMUSG00000031503	Col4a2	mmu:12827; P08122; Q3B7C2; Q3TPV9; Q61375; Q66JS5; Q6RCT6; Q6RCT7; Q6U9X1; Q8BPI9; Q8BPK3; Q91VI3	Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Focal adhesion	Laminin interactions; Signaling by PDGF; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions	0.352816378116182	0.64759425713406	0.293387877727491	0.79866917976589	0.979628232635575	0.169673447599406	0.959159975702413	0.483015668880262	1499335.01530309	1691518.00623855	989751.415380184	1393534.8123072747	5.53234274481973E7	5.88619201086468E7	3.63990683013196E7	5.0194805286054574E7	1.35123643610626E7	1.30555597235297E7	1.53773176128868E7	1.3981747232493034E7	6.80333035906639E7	6.55922447276284E7	4.55601360762201E7	5.972856146483746E7	9511844.25395737	2.43703078917008E7	1.71661195678148E7	1.701609057115766E7
Q3U962	Collagen alpha-2(V) chain [OS=Mus musculus]	518.514	64	57	817	55	1497	144.9	cell organization and biogenesis;developmental processes;other biological processes	extracellular matrix;other cell component	extracellular structural activity;other molecular function	12832	ENSMUSG00000026042	Col5a2	mmu:12832; Q3TVR2; Q3U962; Q3UHK7; Q3UTT4; Q3V1J6; Q61431; Q7TMS0; Q80VS8	Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion	Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions	0.861384746267066	0.961254912149485	0.730324052254867	0.632833892117728	0.0769666553885184	0.273444295895674	0.453486790198347	0.973358018692255	1.96082795853326E7	1.89754303457921E7	3.46758133166589E7	2.4419841082594533E7	4.80275081428664E7	4.79991185130461E7	4.1747532446715E7	4.592471970087584E7	1.59204573672189E7	1.42782577106181E7	1.7061559679881E7	1.5753424919239333E7	2.09575588581227E7	1.96948053072084E7	2.25862916575107E7	2.1079551940947264E7	4881772.8383399	8018525.34642114	1.85137908486988E7	1.0471363011153279E7
Q05793	Basement membrane-specific heparan sulfate proteoglycan core protein [OS=Mus musculus]	507.28	33	84	998	84	3707	398	cell organization and biogenesis;transport;developmental processes;other biological processes	non-structural extracellular;extracellular matrix;ER/Golgi	other molecular function	15530		Hspg2	mmu:15530; Q05793			0.332090710292395	0.382764581022518	0.771134174410141	0.553652046981626	0.208890689478245	0.938381933295379	0.285967432697218	0.908661395894721	136795.508290338	206406.403199821	169825.859706297	171009.25706548532	3.70110206606215E7	4.34630743166815E7	4.28074794537461E7	4.109385814368304E7	2.41165287907714E7	1.91842080304052E7	2.07659482289725E7	2.1355561683383033E7	2.10452863152835E7	2.06741361608803E7	1.52751209810576E7	1.8998181152407136E7	5927226.99682882	1.0580617159021E7	8226367.86740312	8244737.341084313
Q61554	Fibrillin-1 [OS=Mus musculus]	499.202	38	86	1117	86	2873	312.1	cell adhesion;other metabolic processes;developmental processes;signal transduction;other biological processes	non-structural extracellular;extracellular matrix	signal transduction activity or receptor binding;extracellular structural activity;other molecular function	14118	ENSMUSG00000027204	Fbn1	A2AQ53; mmu:14118; Q60826; Q61554	Comprehensive IL-17A signaling	Integrin cell surface interactions; Degradation of the extracellular matrix; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; TGF-beta receptor signaling activates SMADs; Molecules associated with elastic fibres	0.0596853092747711	0.0840496117897429	0.378389090130589	0.84258396038376	0.087482121441914	0.862063111456553	0.0455630470425967	0.77820123247099	95282.9912894267	109686.773968107	40225.7464170883	81731.837224874	5.82457893686458E7	6.62931141873392E7	3.19536333419291E7	5.216417896597137E7	2.33066180631659E7	1.9035713753758E7	2.29784126659734E7	2.17735814942991E7	2.39841959808407E7	2.29999435869113E7	1.54925740961197E7	2.082557122129057E7	2575605.08863811	7345083.32475891	5514536.56061601	5145074.9913376765
Q8BTM8	Filamin-A [OS=Mus musculus]	493.069	49	91	915	83	2647	281	cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes	plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component	signal transduction activity or receptor binding;cytoskeletal activity;other molecular function	192176	ENSMUSG00000031328	Flna	B7FAV0; O54934; Q7TQI1; Q8BLK1; Q8BTM8; Q8BTN7; Q8VHX5; Q8VHX8; Q99KQ2	Mapk signaling pathway; Focal adhesion	Platelet degranulation ; Cell-extracellular matrix interactions; RHO GTPases activate PAKs; GP1b-IX-V activation signalling	0.0844935092512095	0.493514006575528	0.170420349138264	0.67528135146603	0.946239447314336	0.864215513767001	0.904360680536565	0.8468455705593	223080.302738683	192779.021360071	239583.24348992	218480.8558628913	1.21506602248127E7	1.23160583881327E7	9719435.76620134	1.1395384793048913E7	4325195.00464495	4176073.86658823	6355593.34436329	4952287.405198824	1.73054238441738E7	1.42527501066511E7	1.24998953996761E7	1.4686023116833666E7	2879720.55833739	5479053.39146785	4531038.34565544	4296604.098486893
P02463	Collagen alpha-1(IV) chain [OS=Mus musculus]	487.707	70	68	828	68	1669	160.6	cell organization and biogenesis;developmental processes;signal transduction;other biological processes	non-structural extracellular;extracellular matrix	extracellular structural activity;other molecular function	12826	ENSMUSG00000031502	Col4a1	mmu:12826; P02463; Q3UHJ4; Q3UJE7; Q3UQV2; Q53X35; Q6GQS7; Q6PHB5; Q99LQ8	Spinal cord injury; Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion	Laminin interactions; Signaling by PDGF; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions	0.604225174343649	0.68008321917751	0.284160251285083	0.936818656936794	0.483508479481234	0.167300285011781	0.777395712279767	0.224623005929948	359769.877634713	285958.835932462	141085.539092917	262271.417553364	2.00868956379824E7	2.17854047157598E7	2.25190928918174E7	2.1463797748519864E7	4657081.16483192	4119739.1632835	5084724.84322114	4620515.057112186	3.91843343162395E7	3.69562703398771E7	2.33283395840594E7	3.3156314746725336E7	6193195.94075903	1.32557370999003E7	7286914.931104	8911949.32392111
Q60847	Collagen alpha-1(XII) chain [OS=Mus musculus]	480.266	40	95	991	95	3120	340	cell adhesion;developmental processes	other cell component		12816	ENSMUSG00000032332	Col12a1	mmu:12816; P70322; Q60847		Assembly of collagen fibrils and other multimeric structures; Collagen chain trimerization; Collagen degradation	0.0975092237649803	1.8644578313253E-17	0.344512840834051	0.162753188077458	0.119424004207039	0.101350980560035	0.0103905836841461	0.266844028199729	98450.5264125119	58090.3600627237	83999.6481680613	80180.17821443231	3.34408474370425E7	3.89438836318894E7	1.74727378978336E7	2.9952489655588504E7	5.74848700994307E7	4.49447732262548E7	5.27793485517261E7	5.1736330625803865E7	1.71723257401258E7	1.50709974901674E7	1.16453026750935E7	1.4629541968462234E7	6848854.24799245	1.38653609093446E7	1.0899125462023E7	1.0537780206453351E7
Q8VDD5	Myosin-9 [OS=Mus musculus]	418.364	45	73	827	60	1960	226.2	cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;stress response;transport;developmental processes;other biological processes	plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component	signal transduction activity or receptor binding;cytoskeletal activity;other molecular function	17886	ENSMUSG00000022443	Myh9	mmu:17886; Q3UHT9; Q3UHU4; Q6KAN6; Q811I2; Q8VDD5	Primary focal segmental glomerulosclerosis (FSGS)	RHO GTPases activate PAKs; Regulation of actin dynamics for phagocytic cup formation	0.156498497144098	0.0382609387499984	0.118876667035285	0.15125389278925	0.87421335771164	0.916542675526027	0.91728043005175	0.990873516209569	107483.529676039	153800.887463573	39674.4269878413	100319.6147091511	8783012.74886087	9974545.70796386	5444477.78467149	8067345.413832072	4748384.28257292	4410554.6604061	6370665.87897293	5176534.940650649	2.10207699044932E7	2.09758895852136E7	1.72823293907493E7	1.9759662960152034E7	5517905.75659883	9476865.41359831	8538625.93793802	7844465.70271172
Cont_P02453	Collagen alpha-1(I) chain OS=Bos taurus OX=9913 GN=COL1A1 PE=1 SV=3	414.689	43	43	1208	4	1463	138.9	cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes	non-structural extracellular;extracellular matrix;other cell component	extracellular structural activity;other molecular function	282187	ENSBTAG00000013103	COL1A1	bta:282187; P02453; Q3MHM2	Inflammatory response pathway; Osteoblast signaling; Focal adhesion	Fibronectin matrix formation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Collagen degradation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; Collagen chain trimerization; GPVI-mediated activation cascade; Platelet Aggregation (Plug Formation); Platelet Adhesion to exposed collagen; GP1b-IX-V activation signalling	0.800889767710788	0.579410556046386	0.58548007712969	0.839216523231753	0.067749585016969	0.848119069115724	0.108042253370914	0.0107964100780951	246464.336302772	276104.509600215	163058.776827813	228542.54091026666	4343807.62117337	4270443.00602544	3115927.46864821	3910059.36528234	3219828.72869598	3183952.03023541	3383679.40073467	3262486.7198886867	941743.224351002	1075861.66368366	756862.710693879	924822.5329095138	876331.391932507	1065336.29340721	1364509.18546901	1102058.9569362423
Cont_P02769	Albumin OS=Bos taurus OX=9913 GN=ALB PE=1 SV=4	390.555	81	57	7095	54	607	69.2	stress response;other biological processes	non-structural extracellular;other cell component	nucleic acid binding activity;other molecular function	280717		ALB	A5PJX3; bta:280717; O02787; P02769; P04277; Q3SZR2			0.520832629933248	0.650544967914241	0.598172767155558	0.497906326712893	0.946568086066385	0.413798631523592	0.846117085258013	0.468531677746422	3.41035277502904E9	3.06531085647989E9	1.66716629813739E9	2.7142766432154403E9	2.0547979326133E9	2.37062763488737E9	2.78500610382043E9	2.4034772237737E9	3.09362764542436E9	2.55631644026836E9	3.07992745656962E9	2.9099571807541137E9	2.97814649224141E9	2.86277256421772E9	2.21144220575444E9	2.6841204207378564E9	2.22855277531216E9	3.25384623573346E9	1.66052966718895E9	2.38097622607819E9
P01027	Complement C3 [OS=Mus musculus]	388.541	53	70	1148	62	1663	186.4	cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes	non-structural extracellular;other cell component	signal transduction activity or receptor binding;enzyme regulator activity	12266	ENSMUSG00000024164	C3	mmu:12266; P01027; Q61370; Q80XP1	Complement activation, classical pathway; Tyrobp causal network in microglia; Comprehensive IL-17A signaling	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade; Neutrophil degranulation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; G alpha (i) signalling events; Peptide ligand-binding receptors; Alternative complement activation; Activation of C3 and C5	0.712660037675161	0.729783028721347	0.506101547380209	0.762068821001752	0.939492000987438	0.512232143465318	0.413470300505934	0.991722673088443	4040096.73815256	3926631.83282415	1843021.41157313	3269916.660849947	4.04154698805798E7	4.4896658832648E7	4.8335201547635E7	4.4549110086954266E7	1.80671896153384E7	1.47828809765086E7	1.7121367805152E7	1.6657146132333001E7	9.88883606977539E7	8.1974398309486E7	5.99376709525504E7	8.026680998659676E7	2.84159228355073E7	4.96444404075474E7	3.21393016835685E7	3.6733221642207734E7
Cont_Q7SIH1	Alpha-2-macroglobulin OS=Bos taurus OX=9913 GN=A2M PE=1 SV=2	370.864	53	56	1089	56	1510	167.5		non-structural extracellular	enzyme regulator activity;other molecular function	513856	ENSBTAG00000018137	A2M	A8E647; bta:513856; Q7SIH1	IL-6 signaling pathway		0.688450665125024	0.839052280267302	0.731111241255251	0.509007335932165	0.944154202827561	0.540124873725708	0.671798309985569	0.809503222445875	5.71770657169572E7	6.35766951637367E7	4.19549690627817E7	5.423624331449187E7	6.46032237401637E7	7.37926671048822E7	7.2164410166051E7	7.018676700369896E7	8.06000315293491E7	7.23429494984619E7	7.40068576999505E7	7.564994624258716E7	8.7810317845685E7	9.50258669209954E7	6.46884849507494E7	8.250822323914327E7	3.96461495018234E7	7.63451634810678E7	4.10565401116459E7	5.23492843648457E7
Cont_Q29443	Serotransferrin OS=Bos taurus OX=9913 GN=TF PE=2 SV=1	343.183	74	48	1709	46	704	77.7	stress response;transport;other biological processes	non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle	other molecular function	280705		TF	bta:280705; Q0IIK2; Q29443			0.615274986253429	0.964709887217926	0.600414647182016	0.571407162236119	0.902231721267411	0.105569810421019	0.506704636011438	0.313748671859839	1.71679936327392E8	1.91001417946965E8	8.41149187199369E7	1.48932090998098E8	1.24867801818358E8	1.55146358811954E8	1.88178132242021E8	1.5606409762411097E8	2.69795837029218E8	2.21755859229163E8	2.04768415701638E8	2.32106703986673E8	1.81082969779594E8	1.61167381210782E8	1.45463022007429E8	1.6257112433260167E8	1.38609619584445E8	1.76572700073531E8	9.18433757916485E7	1.3567523181654152E8
Cont_P07589	Fibronectin OS=Bos taurus OX=9913 GN=FN1 PE=1 SV=4	337.517	26	47	923	11	2478	272	cell adhesion;cell organization and biogenesis;stress response;developmental processes;other biological processes	non-structural extracellular	signal transduction activity or receptor binding;other molecular function			FN1	P07589			0.714071857030863	0.525827426782658	0.94971810013306	0.802863674292211	0.553450172742796	0.634088329627404	0.35834247597224	0.281927255363179	142865.797461343	209169.389049115	146732.075795441	166255.75410196633	1055759.20189889	1052518.92691246	748231.640959004	952169.9232567847	927817.269350189	797644.80797335	782189.414628216	835883.8306505851	683356.768802769	735882.167003896	388557.285212602	602598.7403397557	334439.098432858	506951.879121439	606468.327162644	482619.7682389803
Q80X90	Filamin-B [OS=Mus musculus]	335.882	38	75	608	66	2602	277.7	cell organization and biogenesis;stress response;other biological processes	plasma membrane;other membranes;cytosol;cytoskeleton;other cell component	cytoskeletal activity;other molecular function	286940	ENSMUSG00000025278	Flnb	E9QNV9; mmu:286940; Q80X90; Q8VHX4; Q8VHX7; Q99KY3		ISG15 antiviral mechanism	0.296944306247309	0.238365792894698	0.254729742039053	0.629546282386664	0.936411452199724	0.897564267605108	0.872448101434609	0.866446545996913	201569.562939035	74814.3999578854	187488.727848728	154624.23024854946	5908241.65562211	7025090.54357015	5213153.27323614	6048828.490809467	2307098.04671866	1545558.91097354	3200680.70273347	2351112.5534752235	8948631.41531232	7437294.37435051	6391778.7211006	7592568.170254476	1318356.62479586	2409815.97001446	1867290.64861647	1865154.4144755967
Cont_P35527	Keratin, type I cytoskeletal 9 OS=Homo sapiens OX=9606 GN=KRT9 PE=1 SV=3	310.424	69	35	915	34	623	62	cell organization and biogenesis;other biological processes	cytosol;cytoskeleton	cytoskeletal activity	3857	ENSG00000171403	KRT9	hsa:3857; O00109; P35527; Q0IJ47; Q14665		Formation of the cornified envelope	0.836660982916281	0.73072258897653	0.769556732848094	0.964570089320365	0.873609880131656	0.936669139837906	0.516448827835279	0.0110179641295352	3.00988862408693E7	2.22166955848562E7	3.53566605858277E7	2.9224080803851068E7	3.83413938796298E7	4.01115354911529E7	4.55013850626263E7	4.1318104811136335E7	3.25056930591839E7	3.99576081794461E7	2.50556157717982E7	3.250630567014273E7	4.79768166310243E7	2.93517742058567E7	7.69722436015544E7	5.1433611479478456E7	9.27838604678364E7	5.6604390657593E7	1.31711700890849E8	9.369998400542612E7
Cont_P04264	Keratin, type II cytoskeletal 1 OS=Homo sapiens OX=9606 GN=KRT1 PE=1 SV=6	306.58	65	45	1774	36	644	66	cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes	non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component	bone, tooth or skin structural activity;other molecular function	3848	ENSG00000167768	KRT1	B2RA01; hsa:3848; P04264; P85925; P86104; Q14720; Q6GSJ0; Q9H298	Corticotropin-releasing hormone signaling	Formation of the cornified envelope; Neutrophil degranulation; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	0.65780924735352	0.653826967689551	0.631165145316661	0.89629386854896	0.873609880131656	0.770634810212039	0.254077056479593	5.78940441291519E-5	1.31038801811221E8	1.49848314576813E8	1.81048519054156E8	1.5397854514739665E8	1.64179912336924E8	1.70861004616453E8	1.60803236136221E8	1.6528138436319932E8	1.32005397364365E8	1.61355773356369E8	1.09071204525108E8	1.3414412508194733E8	1.84835731298625E8	1.38277867637903E8	2.0582953187505E8	1.7631437693719265E8	3.95085049343759E8	3.00261678765842E8	6.47574942932283E8	4.476405570139613E8
P06909	Complement factor H [OS=Mus musculus]	292.01	49	41	540	41	1234	139	cell adhesion;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes	non-structural extracellular;plasma membrane;other membranes;mitochondrion;other cell component	other molecular function	12628	ENSMUSG00000026365	Cfh	mmu:12628; P06909; Q6NZK3		Regulation of Complement cascade	0.205200089226065	0.0359547312524068	1.50457038391225E-17	0.329485122608543	0.678323397545056	0.532399788858771	0.750662231008662	0.443116920082088	45833.2314948132	5719.34924483144	127074.400703141	59542.32714759521	9199603.23733176	9631512.57691777	1.22513356989878E7	1.036081717107911E7	1.13946236540082E7	8948376.12127358	1.13575209573925E7	1.0566840244224759E7	3.40837407850627E7	2.84575354110008E7	2.55312981422866E7	2.9357524779450033E7	6857257.31092971	1.08034871236965E7	7658800.41775084	8439848.284125684
P16546	Spectrin alpha chain, non-erythrocytic 1 [OS=Mus musculus]	291.854	35	74	473	74	2472	284.4	cell organization and biogenesis	plasma membrane;other membranes;cytosol;cytoskeleton;other cell component	cytoskeletal activity;other molecular function	20740	ENSMUSG00000057738	Sptan1	A3KGU6; A3KGU8; P16546; Q8K380; Q9CT05	FAS pathway and stress induction of HSP regulation	Neutrophil degranulation; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Interaction between L1 and Ankyrins; COPI-mediated anterograde transport; RHOU GTPase cycle; RHOV GTPase cycle; Caspase-mediated cleavage of cytoskeletal proteins	0.958962194559628	0.786160319109602	0.611910908670005	0.890289034593217	0.929383260195332	0.771887919257916	0.870511801558508	0.852906094467594	889916.065158961	705414.766907556	458549.490375553	684626.7741473566	4175162.43226982	4600176.71769719	3155429.78771999	3976922.979229001	1301153.76848032	907755.21332001	2072924.21437361	1427277.73205798	9282178.93349268	8610756.12905297	6522130.81446154	8138355.29233573	1477626.07784989	2972528.81421804	2340149.67970916	2263434.85725903
Cont_P13645	Keratin, type I cytoskeletal 10 OS=Homo sapiens OX=9606 GN=KRT10 PE=1 SV=6	286.713	62	30	1322	20	584	58.8	cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes	plasma membrane;cytosol;cytoskeleton;other cell component	bone, tooth or skin structural activity;other molecular function	3858	ENSG00000186395	KRT10	hsa:3858; P13645; Q14664; Q8N175		Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	0.600890052902075	0.490821286240141	0.561934876627864	0.941696908693733	0.829734761131295	0.880940844456856	0.246231694954624	2.55433624902191E-5	8.57039306780817E7	1.2308209015436E8	1.23973335952419E8	1.1091978559495355E8	1.09050331614224E8	1.30109606828786E8	1.02692161896587E8	1.13950700113199E8	8.73473050095944E7	1.23031831133367E8	7.19147674496861E7	9.409796786421584E7	1.29238189237995E8	9.43248217623685E7	1.03859326412487E8	1.0914077913761683E8	2.4676744393623E8	2.01230291385254E8	5.11249836753994E8	3.19749190691826E8
Cont_P35908	Keratin, type II cytoskeletal 2 epidermal OS=Homo sapiens OX=9606 GN=KRT2 PE=1 SV=2	284.975	78	42	1022	32	639	65.4	cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes	plasma membrane;cytosol;cytoskeleton;other cell component	bone, tooth or skin structural activity;cytoskeletal activity	3849	ENSG00000172867	KRT2	hsa:3849; P35908; Q4VAQ2		Formation of the cornified envelope	0.499413631103761	0.411258958244596	0.544106843431104	0.933570718645937	0.912218866069753	0.862063111456553	0.309041843038519	2.9837536993241E-4	2.56957016834685E7	6.51011422173888E7	5.25056794690703E7	4.776750778997586E7	3.16465014359267E7	4.04662454773149E7	3.03458785296059E7	3.415287514761583E7	2.58420950665494E7	4.44581259999837E7	1.77732081549674E7	2.9357809740500167E7	3.88601529372083E7	2.41897353529024E7	4.54682916268081E7	3.617272663897294E7	6.73715830359901E7	6.38856203067551E7	9.79668081708945E7	7.640800383787991E7
Q62059	Versican core protein [OS=Mus musculus]	279.715	17	44	1073	44	3357	366.6	cell adhesion;developmental processes	non-structural extracellular;extracellular matrix;other cell component	other molecular function			Vcan	Q62058; Q62059; Q9CUU0		ECM proteoglycans; Glycosaminoglycan-protein linkage region biosynthesis; CS/DS degradation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; CS-GAG biosynthesis; DS-GAG biosynthesis	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.854305439376382	0.613304974369123	0.478009151463064	0.783304059803245	125473.726574878	146060.097046071	41031.8651630982	104188.56292801573	8.44868881898379E7	1.01917408783468E8	9.76252353450265E7	9.467651077277745E7	1.00104936351016E8	8.17450473009677E7	8.92610512588614E7	9.037034497028168E7	1.04839173391366E8	1.06605513712809E8	7.38631920533055E7	9.510262638582683E7	4.44571187520766E7	8.14544543672178E7	5.09261453344577E7	5.89459061512507E7
P10493	Nidogen-1 [OS=Mus musculus]	275.191	43	42	852	42	1245	136.5	cell adhesion;cell organization and biogenesis;developmental processes;other biological processes	non-structural extracellular;extracellular matrix;other cell component	other molecular function	18073	ENSMUSG00000005397	Nid1	mmu:18073; P10493; Q3TKX9; Q8BQI3; Q8C3U8; Q8C9P6		Laminin interactions; Degradation of the extracellular matrix	1.65082956259427E-17	1.8644578313253E-17	0.251140212279038	0.461941385639594	0.013229256333524	0.604382524464811	1.0740690550749E-5	0.781368126060588	439897.722361698	266111.080129006	261357.080833752	322455.2944414853	1.30583493944604E8	1.41493313555848E8	1.08068734992402E8	1.2671518083095133E8	1.1764867041349E8	1.23903817347262E8	1.22059347123012E8	1.2120394496125467E8	3.85653673006923E7	3.40794335543811E7	2.32700802472122E7	3.1971627034095198E7	6809358.71273179	1.16807558295498E7	8950100.03941293	9146738.193898173
O88207	Collagen alpha-1(V) chain [OS=Mus musculus]	275.025	46	52	413	44	1838	183.6	cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes	extracellular matrix;other cell component	extracellular structural activity;other molecular function	12831	ENSMUSG00000026837	Col5a1	A3KGE3; mmu:12831; O88207; Q3UG94; Q6F6B0	Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion	ECM proteoglycans; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; MET activates PTK2 signaling	1.65082956259427E-17	1.8644578313253E-17	0.268653947705267	0.311207075116757	0.189625712887896	0.848119069115724	0.302671730722046	0.809503222445875	12502.6007438316	105962.872602761	122701.039249758	80388.83753211687	8585864.47184676	9052435.86465399	8047799.6262338	8562033.320911517	3715509.90739661	3183478.03245453	3834509.14396516	3577832.3612721	3548034.64380386	3694879.64301103	2052789.86607006	3098568.0509616495	910135.702053452	1926767.56075777	1322438.93167649	1386447.3981625708
P37889	Fibulin-2 [OS=Mus musculus]	269.894	43	37	791	37	1221	131.7	other biological processes	non-structural extracellular	other molecular function	14115	ENSMUSG00000064080	Fbln2	G5E8B3; mmu:14115; P37889; Q9WUI2		Molecules associated with elastic fibres	1.65082956259427E-17	0.0640195441309023	0.201227492083465	0.255240026777032	0.453005417011507	0.803447472095846	0.290132264062119	0.809503222445875	404936.27628206	303410.824570497	379728.902265123	362692.0010392267	7.35240092421165E7	8.16716617206073E7	8.54486063918813E7	8.021475911820169E7	7.34239875271171E7	6.18846762513378E7	6.13955038440774E7	6.556805587417743E7	5.64407337496573E7	5.35180097543675E7	3.80873889057723E7	4.93487108032657E7	2.21115750486307E7	3.84218730879294E7	2.96696416762988E7	3.00676966042863E7
Q8VHX6	Filamin-C [OS=Mus musculus]	249.498	31	65	425	56	2726	290.9	cell organization and biogenesis;other biological processes	plasma membrane;other membranes;cytosol;cytoskeleton;other cell component	cytoskeletal activity	68794	ENSMUSG00000068699	Flnc	B2RY80; B9EKT2; mmu:68794; Q6PAI6; Q8VHX6; Q9JJ38		Cell-extracellular matrix interactions	0.562594032195739	0.719627996749639	0.962331548063155	0.57290809187594	0.976873891151678	0.96786708205164	0.933437821008547	0.80954066750699	362673.376414211	453714.7830589	401875.758519269	406087.97266412666	2896613.16388353	1997446.07055639	1374740.24453431	2089599.8263247435	898320.393102247	899851.262035181	1251187.76236098	1016453.1391661359	4619845.64928082	4224920.76413233	4533386.9985568	4459384.47065665	1245417.60281572	1275359.84004796	889222.28002913	1136666.5742976035
Q04857	Collagen alpha-1(VI) chain [OS=Mus musculus]	248.981	44	33	588	33	1025	108.4	cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes	non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component	other molecular function	12833	ENSMUSG00000001119	Col6a1	mmu:12833; Q04857		ECM proteoglycans; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Signaling by PDGF; NCAM1 interactions	0.2534363617947	0.392208211277376	0.962331548063155	0.971216996811237	0.0353343473113635	0.97504218639442	0.115965329440656	0.380888676065133	99442.7570537982	67304.0023261046	63848.8638629308	76865.2077476112	6.50338448192604E7	8.11264443817216E7	6.12675161034549E7	6.914260176814564E7	5.28406132873544E7	4.53711044962942E7	5.19951028566589E7	5.0068940213435836E7	2.08305860584001E7	2.24322225654869E7	1.63957751491443E7	1.9886194591010433E7	1.00181099527419E7	1.94360212112643E7	1.39653990737858E7	1.4473176745930666E7
Cont_Q2UVX4	Complement C3 OS=Bos taurus OX=9913 GN=C3 PE=1 SV=2	247.154	39	55	851	47	1661	187.1	cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes	non-structural extracellular;other cell component	signal transduction activity or receptor binding;enzyme regulator activity	280677	ENSBTAG00000017280	C3	bta:280677; Q2KIZ4; Q2UVX4	Complement and coagulation cascades; Complement activation, classical pathway	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Neutrophil degranulation; Peptide ligand-binding receptors; G alpha (i) signalling events; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade; Alternative complement activation; Activation of C3 and C5	0.615680953989958	0.798729234704005	0.573945385766997	0.506364847510615	0.87421335771164	0.291700662163587	0.591028379533681	0.448532796991499	1.66248121121728E7	1.69271139045693E7	1.05083515570206E7	1.4686759191254234E7	1.25526666866144E7	1.76991579704635E7	1.56235874907449E7	1.5291804049274266E7	1.80944158276855E7	1.82336027421103E7	1.90370193770683E7	1.84550126489547E7	1.87583360164926E7	1.78001813666833E7	1.18248646641963E7	1.6127794015790733E7	9025681.5960692	1.79617171787325E7	8899645.14317005	1.196234797265725E7
Q62261	Spectrin beta chain, non-erythrocytic 1 [OS=Mus musculus]	244.684	30	61	398	61	2363	274.1	cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes	plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component	cytoskeletal activity;other molecular function	20742	ENSMUSG00000020315	Sptbn1	A2AFU1; mmu:20742; Q3TEM7; Q5SQL8; Q5SQL9; Q62261; Q9QWJ7		COPI-mediated anterograde transport; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; RHOU GTPase cycle; Interaction between L1 and Ankyrins; RHOV GTPase cycle	0.69394578118832	0.776437620310661	0.693719649766064	0.831411077141515	0.937876734191067	0.86315143463057	0.664971370235365	0.953305976192702	373834.445440549	533726.562973047	569801.107945045	492454.03878621367	3103526.47805657	3181731.16602619	2477755.42998989	2921004.358024217	796281.087102098	609431.872132576	1356947.15467432	920886.7046363313	7745784.08821259	6610112.71623617	4897418.35730506	6417771.720584608	1743474.26371724	2723698.32906552	2432765.02616441	2299979.2063157237
Q640N1	Adipocyte enhancer-binding protein 1 [OS=Mus musculus]	239.707	38	34	648	34	1128	128.3	protein metabolism;other biological processes	nucleus;other cell component	nucleic acid binding activity;other molecular function	11568	ENSMUSG00000020473	Aebp1	mmu:11568; O88442; Q3TVV5; Q3TWA7; Q3TX56; Q3TXB2; Q5NCI9; Q61281; Q640N1			0.269326617826563	0.0457359864845759	0.605387748357992	0.631359014803774	0.534291750451691	0.760992448481534	0.145805028390539	0.963436677882021	3560033.84712119	4696620.34449178	6275149.80645163	4843934.666021533	4.59930845855363E7	5.69735867783534E7	2.04646374454636E7	4.1143769603117764E7	3.80233154774145E7	4.02615711999708E7	4.03854487434811E7	3.9556778473622136E7	3.40966164303398E7	3.7490792004469E7	2.41166240785119E7	3.1901344171106894E7	1.40971982755857E7	2.68643149803103E7	1.4983671743246E7	1.8648394999714002E7
P57780	Alpha-actinin-4 [OS=Mus musculus]	239.42	58	45	483	30	912	104.9	cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes	cytoskeleton;nucleus;other cell component	cytoskeletal activity;other molecular function	60595	ENSMUSG00000054808	Actn4	mmu:60595; P57780	Primary focal segmental glomerulosclerosis (FSGS)	Platelet degranulation	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	0.19149089837131	0.921882153462399	0.795351011232032	0.968364585136618	0.938282411159324	5221.79731213346		36578.541519335	20900.169415734228	9107610.67207618	1.00453975465233E7	1.03378326393571E7	9830280.285985528	5095419.11923033	3409382.50707632	5238186.41277381	4580996.01302682	1.31020350186557E7	1.2711162036506E7	9162046.18669404	1.1658414413951913E7	3002316.05426355	5816939.08777499	4501757.36231035	4440337.50144963
Q7TPR4	Alpha-actinin-1 [OS=Mus musculus]	235.529	54	42	511	27	892	103	cell adhesion;cell organization and biogenesis;other biological processes	plasma membrane;other membranes;cytoskeleton;other cell component	signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function	109711	ENSMUSG00000015143	Actn1	mmu:109711; Q7TPR4	Regulation of actin cytoskeleton; Integrin-mediated cell adhesion; Focal adhesion	Platelet degranulation ; RHOF GTPase cycle; RHOBTB2 GTPase cycle; RHOD GTPase cycle; Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	0.995554138371554	0.178726136005694	0.819280225722906	0.941696908693733	0.974207409660283	0.744084716394381	0.837231569641376	0.879972045955715	354073.059499792	209249.076355465	897084.460899514	486802.1989182571	5526121.35104279	6211867.70337129	6893436.45630869	6210475.170240924	2413615.48536692	1933168.81934458	3229981.90899851	2525588.7379033365	1.03807818109957E7	1.11771340173328E7	8282960.99949337	9946958.94260729	2797115.44078374	4939050.64701654	3416305.89125481	3717490.65968503
P02468	Laminin subunit gamma-1 [OS=Mus musculus]	230.882	35	43	454	43	1607	177.2	cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes	non-structural extracellular;extracellular matrix;other cell component	extracellular structural activity;other molecular function			Lamc1	P02468			0.118212047511996	0.116315527815218	0.459134305737471	0.675951294045723	0.3041568870489	0.877818946381645	0.368062651583427	0.922276466908065	14325.5972836352	21883.5466161272		18104.5719498812	1.5357350900924E7	1.57310961044729E7	1.74335709018572E7	1.61740059690847E7	7496762.71625721	6775968.90045745	7708775.93718172	7327169.184632126	9245241.37337628	9035989.05815721	5573559.97495901	7951596.802164167	2368540.67041914	4605215.17131646	2765122.91380764	3246292.9185144133
Q91ZX7	Prolow-density lipoprotein receptor-related protein 1 [OS=Mus musculus]	230.497	15	57	519	56	4545	504.4	other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes	plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component	signal transduction activity or receptor binding;other molecular function	16971		Lrp1	mmu:16971; Q61291; Q91ZX7; Q920Y4	Statin pathway; Wnt signaling pathway	Scavenging of heme from plasma; Retinoid metabolism and transport	1.65082956259427E-17	0.0181625429641231	0.133639440745791	0.150830220548111	0.687557067265551	0.925871264502428	0.74148782464906	0.901098484497789	10237.2255539891		51104.3489937616	30670.78727387535	6875342.47952318	6944806.90573824	8247481.69257335	7355877.025944923	4299652.1243919	2953538.60705284	3392031.85738558	3548407.5296101067	6405748.2654286	5854087.4911046	4914685.84613499	5724840.5342227295	1705219.62694462	2981142.11204421	2044471.2247951	2243610.9879279765
Cont_P60712	Actin, cytoplasmic 1 OS=Bos taurus OX=9913 GN=ACTB PE=1 SV=1	225.45	70	19	852	2	375	41.7	cell organization and biogenesis;stress response;developmental processes;other biological processes	plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component	enzyme regulator activity;cytoskeletal activity;other molecular function	100033878; 100135470; 100173832; 101844587; 102139853; 11461; 118833809; 280979; 396526; 403580; 414396; 443052; 450133; 60; 81822	ENSBTAG00000026199; ENSCAFG00000016020; ENSCAFG00030015381; ENSCAFG00040015695; ENSCPOG00000013467; ENSG00000075624; ENSMAUG00000008763; ENSMUSG00000029580; ENSOARG00040012985; ENSOARG00180022443; ENSOARG00185023855; ENSOARG00215030140; ENSOARG00225009314; ENSPPYG00000017336; ENSPTRG00000018890; ENSRNOG00000034254; ENSSSCG00000007585; ENSSSCG00030003451; ENSSSCG00035038792; ENSSSCG00040049462; ENSSSCG00045027458; ENSSSCG00050065025; ENSSSCG00055012597; ENSSSCG00060019124; ENSSSCG00065037921; ENSSSCG00070011353; ENSSSCG00105030144; ENSSSCG00110026965; ENSSSCG00115013637; ENSSSCG00130033784	Actb; ACTB	A5D961; A5PKA1; bta:280979; cfa:403580; cpoc:100135470; csab:103246953; ecb:100033878; gga:396526; hsa:60; maua:101844587; mmu:11461; O18840; oas:443052; P02570; P60706; P60707; P60708; P60709; P60710; P60711; P60712; P60713; P70514; P99021; pon:100173832; ptr:450133; Q11209; Q11211; Q3SZD2; Q3TI89; Q3TVP6; Q4L0Y2; Q4R561; Q5R1X3; Q5R582; Q5R6G0; Q64316; Q6QAQ1; Q6ZWM3; Q711N9; Q71FK5; Q75MN2; Q76N69; Q8MIJ0; Q8SPX4; Q95164; Q96B34; Q96HG5; rno:81822; ssc:414396	FAS pathway and stress induction of HSP regulation; Actin cytoskeleton regulation; Myometrial relaxation and contraction pathways; Focal adhesion; Arrhythmogenic right ventricular cardiomyopathy; Pathogenic Escherichia coli infection; Common pathways underlying drug addiction; Myometrial relaxation and contraction pathways; Focal adhesion; Fas ligand pathway and stress induction of heat shock proteins; Pathogenic Escherichia coli infection; Arrhythmogenic right ventricular cardiomyopathy; Focal adhesion; Myometrial relaxation and contraction pathways; Regulation of actin cytoskeleton; Myometrial relaxation and contraction pathways; Ebola virus infection in host; Acute viral myocarditis; Thermogenesis; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Overlap between signal transduction pathways contributing to LMNA laminopathies; Pleural mesothelioma; Regulation of actin cytoskeleton; Network map of SARS-CoV-2 signaling; Regulation of actin cytoskeleton; Regulation of actin cytoskeleton; Focal adhesion	Formation of the canonical BAF (cBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); Regulation of actin dynamics for phagocytic cup formation; EPH-ephrin mediated repulsion of cells; Formation of annular gap junctions; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; RHO GTPases Activate Formins; RHOF GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; B-WICH complex positively regulates rRNA expression; Regulation of CDH1 Function; Formation of the dystrophin-glycoprotein complex (DGC); Formation of the canonical BAF (cBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); RHO GTPases Activate WASPs and WAVEs; UCH proteinases; DNA Damage Recognition in GG-NER; Formation of the non-canonical BAF (ncBAF) complex; RHO GTPases activate IQGAPs; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Cell-extracellular matrix interactions; MAP2K and MAPK activation; Interaction between L1 and Ankyrins; RHOF GTPase cycle; DNA Damage Recognition in GG-NER; MAP2K and MAPK activation; RHO GTPases Activate Formins; Clathrin-mediated endocytosis; UCH proteinases; RHOF GTPase cycle; DNA Damage Recognition in GG-NER; EPH-ephrin mediated repulsion of cells; VEGFA-VEGFR2 Pathway; Regulation of actin dynamics for phagocytic cup formation; Adherens junctions interactions; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); RHO GTPases Activate WASPs and WAVEs; B-WICH complex positively regulates rRNA expression; Regulation of CDH1 Function; EPHB-mediated forward signaling; Formation of the non-canonical BAF (ncBAF) complex; Formation of the canonical BAF (cBAF) complex; Formation of annular gap junctions; RHO GTPases activate IQGAPs; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; RHO GTPases Activate WASPs and WAVEs; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RHO GTPases activate IQGAPs; RHO GTPases Activate Formins; RHOF GTPase cycle; Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs); B-WICH complex positively regulates rRNA expression; Signaling by BRAF and RAF1 fusions; UCH proteinases; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; VEGFA-VEGFR2 Pathway; Formation of the dystrophin-glycoprotein complex (DGC); Factors involved in megakaryocyte development and platelet production; Regulation of MITF-M-dependent genes involved in pigmentation; Formation of the canonical BAF (cBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); EPH-ephrin mediated repulsion of cells; HATs acetylate histones; Interaction between L1 and Ankyrins; Prefoldin mediated transfer of substrate to CCT/TriC; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Adherens junctions interactions; Regulation of CDH1 Function; Formation of the non-canonical BAF (ncBAF) complex; DNA Damage Recognition in GG-NER; Formation of the polybromo-BAF (pBAF) complex; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Formation of annular gap junctions; Folding of actin by CCT/TriC; Cell-extracellular matrix interactions; MAP2K and MAPK activation; RHO GTPases Activate Formins; Recycling pathway of L1; RHO GTPases activate IQGAPs; Clathrin-mediated endocytosis; Formation of the dystrophin-glycoprotein complex (DGC); EPHB-mediated forward signaling; UCH proteinases; B-WICH complex positively regulates rRNA expression; Adherens junctions interactions; Formation of the non-canonical BAF (ncBAF) complex; Formation of annular gap junctions; Formation of the polybromo-BAF (pBAF) complex; VEGFA-VEGFR2 Pathway; Cell-extracellular matrix interactions; RHO GTPases Activate WASPs and WAVEs; Regulation of CDH1 Function; Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; UCH proteinases; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); Formation of the polybromo-BAF (pBAF) complex; B-WICH complex positively regulates rRNA expression; DNA Damage Recognition in GG-NER; Formation of the canonical BAF (cBAF) complex; RHO GTPases Activate Formins; Regulation of CDH1 Function; Interaction between L1 and Ankyrins; RHOF GTPase cycle; Formation of the non-canonical BAF (ncBAF) complex; Adherens junctions interactions; Formation of the dystrophin-glycoprotein complex (DGC); VEGFA-VEGFR2 Pathway; RHO GTPases Activate WASPs and WAVEs; Cell-extracellular matrix interactions; EPHB-mediated forward signaling; MAP2K and MAPK activation; Recycling pathway of L1; RHO GTPases activate IQGAPs; Formation of annular gap junctions; B-WICH complex positively regulates rRNA expression; UCH proteinases; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); MAP2K and MAPK activation; Formation of the polybromo-BAF (pBAF) complex; RHO GTPases Activate Formins; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases Activate WASPs and WAVEs; Formation of the dystrophin-glycoprotein complex (DGC); VEGFA-VEGFR2 Pathway; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; DNA Damage Recognition in GG-NER; RHOF GTPase cycle; Cell-extracellular matrix interactions; Adherens junctions interactions; Formation of the non-canonical BAF (ncBAF) complex; Formation of the canonical BAF (cBAF) complex; RHO GTPases activate IQGAPs; Regulation of CDH1 Function; Gap junction degradation; Formation of annular gap junctions; Regulation of actin dynamics for phagocytic cup formation; RHOF GTPase cycle; Clathrin-mediated endocytosis; RHO GTPases Activate Formins; Cell-extracellular matrix interactions; VEGFA-VEGFR2 Pathway; Adherens junctions interactions; RHO GTPases activate IQGAPs; UCH proteinases; EPHB-mediated forward signaling; MAP2K and MAPK activation; RHO GTPases Activate WASPs and WAVEs; Formation of the dystrophin-glycoprotein complex (DGC); Formation of annular gap junctions; Formation of the canonical BAF (cBAF) complex; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of the non-canonical BAF (ncBAF) complex; Regulation of CDH1 Function	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.946568086066385	0.994348552930242	0.963278515868644	0.938282411159324	1924782.99006244	2098949.09709163	1966246.27612296	1996659.4544256767	6.9333476629433E7	7.92679608662888E7	4.66219167617927E7	6.5074451419171505E7	4.31411746831055E7	4.48147974340301E7	5.69102455002969E7	4.828873920581084E7	1.21577893646273E8	1.207324829685E8	8.72162161647777E7	1.0984219759318356E8	3.75040107769213E7	6.67519874410893E7	5.58171302270344E7	5.335770948168167E7
P63260	Actin, cytoplasmic 2 [OS=Mus musculus]	217.791	70	19	831	2	375	41.8	cell organization and biogenesis;stress response;developmental processes;other biological processes	non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component	cytoskeletal activity;other molecular function	11465	ENSMUSG00000062825	Actg1	mmu:11465; P02571; P14104; P63260; P99022	Myometrial relaxation and contraction pathways; Regulation of actin cytoskeleton; Focal adhesion	Platelet degranulation ; RHO GTPases activate IQGAPs; Adherens junctions interactions; Regulation of CDH1 Function; RHO GTPases Activate Formins; Regulation of actin dynamics for phagocytic cup formation; Interaction between L1 and Ankyrins; MAP2K and MAPK activation; Recycling pathway of L1; Clathrin-mediated endocytosis; Formation of the dystrophin-glycoprotein complex (DGC); EPHB-mediated forward signaling; RHOF GTPase cycle; Formation of annular gap junctions; VEGFA-VEGFR2 Pathway; Cell-extracellular matrix interactions; RHO GTPases Activate WASPs and WAVEs; RHOBTB2 GTPase cycle	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.85271451854395	0.901789796153066	0.731487178650893	0.819844267712751					345218.530665522	243712.893345201	175067.879334021	254666.434448248	138179.400499307	114235.784978709	184680.44906409	145698.54484736864	283414.957020267	357431.419092683	129167.257177683	256671.2110968777	47386.9835565671	139954.449837086	191405.076269325	126248.83655432604
P33434	72 kDa type IV collagenase [OS=Mus musculus]	212.03	56	30	889	30	662	74.1	cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes	extracellular matrix;plasma membrane;other membranes;cytoskeleton;mitochondrion;nucleus;other cell component	other molecular function	17390	ENSMUSG00000031740	Mmp2	mmu:17390; P33434	Lung fibrosis; IL-3 signaling pathway; Matrix metalloproteinases	Collagen degradation; Extra-nuclear estrogen signaling; EPH-ephrin mediated repulsion of cells; Activation of Matrix Metalloproteinases	0.372996577396536	0.964209443670126	0.342075680986172	0.708142491896103	0.993994198406889	0.459747209584207	0.34519376377552	0.809503222445875	1.45817945044039E7	3.99854546791863E7	2.31586213408419E7	2.5908623508144036E7	6.16168347215595E7	6.71128653428481E7	5.47627512450794E7	6.116415043649567E7	2.153095933586E7	2.04088973517033E7	2.1514079157928E7	2.11513119484971E7	9.59427020238632E7	8.49468673692442E7	8.11217362792938E7	8.73371018908004E7	3.5725700482165E7	6.85636819548367E7	5.65046943814106E7	5.359802560613743E7
P19096	Fatty acid synthase [OS=Mus musculus]	203.372	23	48	335	48	2504	272.3	other metabolic processes;stress response;other biological processes	plasma membrane;other membranes;cytosol;ER/Golgi;other cell component	other molecular function	14104	ENSMUSG00000025153	Fasn	B1ATU8; mmu:14104; P19096; Q6PB72; Q8C4Z0; Q9EQR0	Fatty acid biosynthesis; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-9 fatty acid synthesis; Elongation of (very) long chain fatty acids	Fatty acyl-CoA biosynthesis; Vitamin B5 (pantothenate) metabolism	0.66189768147619	0.847457711018997	0.951921622352553	0.605074788683686	0.87421335771164	0.994834213681465	0.746782404466558	0.990873516209569	48161.514825801		157425.136778521	102793.32580216101	3018838.26514359	3331564.42510829	1838171.31939824	2729524.669883373	1125050.80259593	1067574.24276956	1976727.22395058	1389784.0897720233	3354008.01034064	3348654.9716265	2283763.91979924	2995475.6339221266	618361.207888453	1151575.74161029	908323.020723558	892753.3234074336
Cont_Q3SZ57	Alpha-fetoprotein OS=Bos taurus OX=9913 GN=AFP PE=2 SV=1	202.89	62	30	1153	29	610	68.5	other metabolic processes;developmental processes;other biological processes	non-structural extracellular;other cell component	other molecular function	506011	ENSBTAG00000017131	AFP	bta:506011; Q3SZ57		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation	0.540832988168188	0.82964085881652	0.605387748357992	0.553772240900005	0.938859506774495	0.15729598575093	0.699570390946254	0.323545662226049	4.4629857016799E7	4.39639700572647E7	2.72178105183923E7	3.8603879197485335E7	3.15168703669999E7	4.26075077823651E7	3.4328683389093E7	3.6151020512819335E7	4.8541823037709E7	4.32960721364381E7	4.4115949306695E7	4.5317948160280704E7	4.61564880446121E7	4.7548077639711E7	3.504265434565E7	4.2915740009991035E7	3.01476017178829E7	5.24042356620578E7	2.7823391939759E7	3.679174310656657E7
P48678	Prelamin-A/C [OS=Mus musculus]	202.607	60	37	529	36	665	74.2	cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes	other membranes;cytoskeleton;nucleus;other cell component	other molecular function	16905	ENSMUSG00000028063	Lmna	B3RH23; B3RH24; mmu:16905; P11516; P48678; P97859; Q3TIH0; Q3TTS8; Q3U733; Q3U7I5; Q3UCA0; Q3UCJ8; Q3UCU3; Q91WF2; Q9DC21	Adipogenesis genes; FAS pathway and stress induction of HSP regulation		1.65082956259427E-17	0.00670345592293191	0.139423967594304	1.70336894001643E-17	0.236076921565588	0.77212820363828	0.901149690306505	0.00692305873191716	56886.7483713492	69336.1384695612	100943.444664856	75722.11050192213	1.29312831685903E7	1.22006597313063E7	8045013.512583	1.1058985470826533E7	3337288.2268023	3262868.75019265	5804803.63611667	4134986.871037207	6.75536277126862E7	5.59333072922179E7	3.75993669940438E7	5.369543399964929E7	4234323.21548912	7210898.93259597	7422846.33935557	6289356.16248022
Q02788	Collagen alpha-2(VI) chain [OS=Mus musculus]	202.37	41	36	585	36	1034	110.3	cell adhesion;signal transduction;other biological processes	non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component	other molecular function	12834	ENSMUSG00000020241	Col6a2	mmu:12834; Q02788; Q05505; Q8C972; Q8K229	Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion	ECM proteoglycans; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation	0.175734701097799	1.8644578313253E-17	0.633123216104285	0.767312384697355	0.156641881403766	0.880899056945259	0.0961283818482991	0.809503222445875	66343.4096791777	224638.480326659	72730.0086108415	121237.29953889274	5.06665581594054E7	6.05623117299827E7	4.51585075606234E7	5.21291258166705E7	4.3575871784427E7	3.72580130101725E7	4.32608904810994E7	4.136492509189963E7	2.4375983761655E7	2.22548052919965E7	1.51565723805374E7	2.0595787144729633E7	7758608.50160191	1.64425759910943E7	1.09937351728106E7	1.173163988850227E7
P97927	Laminin subunit alpha-4 [OS=Mus musculus]	199.33	30	41	409	41	1816	201.7	cell adhesion;developmental processes;other biological processes	non-structural extracellular;extracellular matrix;other cell component	signal transduction activity or receptor binding	16775	ENSMUSG00000019846	Lama4	mmu:16775; O88785; P70409; P97927; Q14BF2	Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion	Formation of the dystrophin-glycoprotein complex (DGC); Laminin interactions; MET activates PTK2 signaling	0.496649188935323	0.645007535999596	0.952104483873957	0.825047045401531	0.329011090732691	0.929291541980042	0.50594120050135	0.819844267712751	540030.170801593	370746.050286439	259459.878107817	390078.69973194966	8261193.64464048	1.06712284071143E7	1.21929154576081E7	1.037511250312096E7	5309597.35327991	4688186.1422195	5379156.74886131	5125646.74812024	6459712.32980478	5951943.81149588	4870147.4483696	5760601.1965567535	2775962.47504545	3878847.28463652	2541823.46940274	3065544.409694903
P20152	Vimentin [OS=Mus musculus]	183.446	60	29	762	27	466	53.7	cell organization and biogenesis;stress response;developmental processes;other biological processes	plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component	cytoskeletal activity;nucleic acid binding activity;other molecular function	22352	ENSMUSG00000026728	Vim	mmu:22352; O08704; P20152; Q8CCH1	Spinal cord injury; Primary focal segmental glomerulosclerosis (FSGS); Alpha 6 beta 4 integrin signaling pathway	Aggrephagy; Striated Muscle Contraction; Caspase-mediated cleavage of cytoskeletal proteins; RHOBTB1 GTPase cycle	1.65082956259427E-17	0.0955146622024883	1.50457038391225E-17	0.137621774180062	0.873609880131656	0.0297998664849654	0.840672080806375	0.0332723373064956	573727.34417641	968981.536762911	1794707.43115169	1112472.104030337	4.14069582585024E7	3.33312643886138E7	2.54656192896882E7	3.3401280645601466E7	6941733.99810384	6173483.46835617	8980531.63051753	7365249.698992513	8.80704815958352E7	8.07026224155391E7	5.51524218564722E7	7.464184195594883E7	6861556.37440952	1.68923991921504E7	1.5029979690535E7	1.292797841903164E7
Q64727	Vinculin [OS=Mus musculus]	182.753	50	45	419	45	1066	116.6	cell adhesion;cell organization and biogenesis;developmental processes;other biological processes	plasma membrane;other membranes;cytoskeleton;other cell component	cytoskeletal activity;other molecular function	22330	ENSMUSG00000021823	Vcl	mmu:22330; Q64727; Q8BP32; Q8BS46; Q922C5; Q922D9	Primary focal segmental glomerulosclerosis (FSGS); IL-3 signaling pathway; Regulation of actin cytoskeleton; Integrin-mediated cell adhesion; Focal adhesion	Neutrophil degranulation; High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells; Platelet degranulation ; MAP2K and MAPK activation; Smooth Muscle Contraction; Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells; Regulation of CDH1 Function	0.208404050858596	0.190838415616571	0.238791978742132	0.504745711776551	0.964629994744883	0.878264980963866	0.977491813528386	0.958518237573655	199164.849916128	87100.0128702587	92185.322880836	126150.06188907423	5675245.0989599	5838625.66584249	3008640.49360623	4840837.086136207	1870082.63283096	1414114.90526218	2577750.73562883	1953982.7579073233	7844023.43396073	7226639.25078312	5204108.91618431	6758257.200309387	1587883.53032107	3146179.30802337	2343388.9049214	2359150.5810886133
Q8K4G1	Latent-transforming growth factor beta-binding protein 4 [OS=Mus musculus]	180.216	27	29	318	29	1666	178.5	cell-cell signaling;cell organization and biogenesis;transport;signal transduction	non-structural extracellular;extracellular matrix	other molecular function	108075	ENSMUSG00000040488	Ltbp4	E9QPD9; mmu:108075; Q8K4G0; Q8K4G1		TGF-beta receptor signaling activates SMADs; Molecules associated with elastic fibres	0.308350896322176	0.362779483059131	1.50457038391225E-17	0.170566190602959	0.775297640004946	0.958956615096849	0.703189639676216	0.915193515309545	20541.0495723262	79596.1275426221		50068.58855747415	2657106.34177438	3398147.96764637	1365787.73467607	2473680.681365607	1578272.63307431	1205878.60177515	1625778.79640944	1469976.6770863	7998382.13678965	8274900.61088866	5600614.51816097	7291299.088613093	1154237.54308251	3609675.59166937	3209012.09868788	2657641.7444799202
Q68FD5	Clathrin heavy chain 1 [OS=Mus musculus]	180.117	32	43	363	43	1675	191.4	cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes	plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component	nucleic acid binding activity;other molecular function	67300	ENSMUSG00000047126	Cltc	mmu:67300; Q68FD5	IL-7 signaling pathway; Kit receptor signaling pathway	MHC class II antigen presentation; Recycling pathway of L1; Cargo recognition for clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis; LDL clearance; Retrograde neurotrophin signalling; Formation of annular gap junctions; Lysosome Vesicle Biogenesis; WNT5A-dependent internalization of FZD4; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation; RHOU GTPase cycle; RHOV GTPase cycle	0.4248536990637	0.198232028950426	1.50457038391225E-17	0.413413145615294	0.688274955487563	0.840666598828607	0.946476383814868	0.835383236382767	19752.350121194		9410.067942265	14581.209031729499	2001079.20697008	2709198.63758679	1592899.41627153	2101059.0869428	1121542.74388673	1205380.43272811	1952895.490984	1426606.2225329466	7620271.96644723	6531411.29627789	6339405.19264676	6830362.818457293	1288866.59437226	2734753.66820203	2211269.42731124	2078296.563295177
P02469	Laminin subunit beta-1 [OS=Mus musculus]	179.863	27	40	429	39	1786	197	cell adhesion;cell organization and biogenesis;developmental processes;other biological processes	non-structural extracellular;extracellular matrix;nucleus;other cell component	signal transduction activity or receptor binding;extracellular structural activity;other molecular function	16777	ENSMUSG00000002900	Lamb1	E9PXZ9; P02469	Focal adhesion: PI3K-Akt-mTOR signaling pathway; Inflammatory response pathway; Alpha 6 beta 4 integrin signaling pathway; Focal adhesion		0.205801242418232	0.341417478664423	0.526489846375643	0.891178501081124	0.269583968882479	0.900334730044572	0.356773085915651	0.98779298590131	1.07332672254E7	1.09845016908001E7	9663847.07936098	1.0460538665187027E7	1.70142446901215E7	1.73820787777271E7	2.08268192848537E7	1.8407714250900764E7	1.23074043806854E7	1.3842748821146E7	1.68288599063313E7	1.4326337702720901E7	1.20697658178524E7	1.33872705970957E7	9031275.37365186	1.149610392953332E7	2.54341447554609E7	1.6513199650281E7	2.12878061302996E7	2.1078383512013834E7
Q01853	Transitional endoplasmic reticulum ATPase [OS=Mus musculus]	179.055	52	32	411	32	806	89.3	cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;other biological processes	other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component	signal transduction activity or receptor binding;enzyme regulator activity;other molecular function	269523	ENSMUSG00000028452	Vcp	mmu:269523; Q01853; Q3TFH9; Q3TIM2; Q3TXN9; Q6PI18; Q8BSR6; Q8CEG4	IL-9 signaling pathway	RHOH GTPase cycle; Neutrophil degranulation; Protein methylation; Ovarian tumor domain proteases; Neddylation; ABC-family proteins mediated transport; Translesion Synthesis by POLH; Hedgehog ligand biogenesis; KEAP1-NFE2L2 pathway; HSF1 activation; N-glycan trimming in the ER and Calnexin/Calreticulin cycle; Josephin domain DUBs	0.915230778358139	0.645007535999596	0.808626104853287	0.953867932777128	0.953038161729767	0.877818946381645	0.901149690306505	0.737824045087029	462345.280919521	876653.458620268	526426.850526767	621808.5300221853	1.01571081063743E7	9889323.38925712	7942233.31155878	9329554.935730066	4702185.44070802	4580279.55870278	6732778.24078372	5338414.413398174	1.50535993864462E7	1.350776734351E7	9751498.62422888	1.2770955118061693E7	3881002.94215154	5380991.32313934	4128956.06599177	4463650.11042755
Q03350	Thrombospondin-2 [OS=Mus musculus]	178.303	35	30	328	29	1172	129.8	cell adhesion;other biological processes	non-structural extracellular;extracellular matrix;other cell component	other molecular function	21826	ENSMUSG00000023885	Thbs2	mmu:21826; Q03350; Q8CG21	Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion	Signaling by PDGF; O-glycosylation of TSR domain-containing proteins	0.425958502904743	0.861805134687803	0.49027994509233	0.535702081245677	0.792896707923278	0.900334730044572	0.620448351319483	0.80954066750699	2258622.92192986	2382783.54746756	1148078.18193404	1929828.2171104867	1.31796330485542E7	1.5104624453426E7	5024405.63191042	1.1102887711296873E7	7531099.32555027	7013388.1367688	7773703.92822199	7439397.130180354	1.11743686938308E7	1.16923792648853E7	8892616.7561804	1.05864549049655E7	2163159.37338424	5673668.48605754	4798999.04450137	4211942.301314384
Q80YX1	Tenascin [OS=Mus musculus]	175.9	28	43	191	43	2110	231.7	cell adhesion;cell-cell signaling;cell organization and biogenesis;stress response;developmental processes;other biological processes	non-structural extracellular;extracellular matrix;other cell component	signal transduction activity or receptor binding;other molecular function	21923	ENSMUSG00000028364	Tnc	mmu:21923; Q64706; Q80YX1; Q80YX2	Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion	Integrin cell surface interactions; ECM proteoglycans; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation	0.117980756369098	0.827773046590747	0.560799429150649	0.474732236495646	1.08858887903907E-8	0.00280630917527262	0.00972980877962454	0.46732263590517	11007.0641239407	22426.4186578027	29153.7668969926	20862.416559578665	1.62969685459921E7	1.53776908456905E7	4644794.12302626	1.2106484504902953E7	1608421.63729791	1232799.46655266	1507622.18059477	1449614.4281484466	244493.865771831	206768.885305398	181767.385360463	211010.04547923067	48104.5148614081	121500.029653831	119126.026959952	96243.5238250637
Q61147	Ceruloplasmin [OS=Mus musculus]	175.43	36	33	380	33	1061	121.1	cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes	non-structural extracellular	other molecular function	12870	ENSMUSG00000003617	Cp	mmu:12870; Q61147; Q6P5C8		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Iron uptake and transport; Metal ion SLC transporters	1.65082956259427E-17	0.0286042496128814	0.232756100865398	0.470567140616547	0.114472406028442	0.902824569867946	0.217345018530886	0.830251457557488	174325.913751449	58856.3090021062	115033.849364799	116072.0240394514	9557281.19120236	1.04767827169696E7	8762702.67228452	9598922.193485493	5461844.00566682	4018732.98956624	4629071.77649001	4703216.257241024	4355240.25919752	3723693.63350954	2684226.57769155	3587720.1567995367	1720243.51649846	1992732.45731179	1556963.66647869	1756646.5467629798
Q3UQ28	Peroxidasin homolog [OS=Mus musculus]	173.636	35	39	366	39	1475	165	cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes	extracellular matrix;ER/Golgi;other cell component	extracellular structural activity;other molecular function	69675	ENSMUSG00000020674	Pxdn	A4FU83; E9QNQ9; mmu:69675; Q3UQ28		Crosslinking of collagen fibrils	0.121749369203589	0.199060935853007	0.481687712882875	0.64860195920101	0.414844709855988	0.680311384167738	0.622521206052951	0.910753558746772	41306.9360165718	84058.3874627107	31201.070658041	52188.79804577449	9910595.89492489	1.28240532958945E7	7690537.3381544	1.0141728842991263E7	3188445.14026578	3418561.86158515	3797799.58981602	3468268.863888983	6834484.53714744	5848987.74573488	4912888.48741006	5865453.59009746	743355.386480967	2642059.33003837	1858779.55214279	1748064.7562207088
Q61316	Heat shock 70 kDa protein 4 [OS=Mus musculus]	169.044	48	31	300	31	841	94.1	protein metabolism;other metabolic processes	other cell component	other molecular function			Hspa4	Q61316		Regulation of HSF1-mediated heat shock response	0.675982462193546	0.947627746595709	0.704651587991194	0.760498481134506	0.937908804051419	0.922660568001848	0.905946265571965	0.842404289073844	22434.4697799145	118934.685179003	13120.5332518918	51496.56273693644	3090247.7626811	3632683.19217962	4934376.07998548	3885769.0116153997	1752659.26658268	1094548.72984359	2299362.24833368	1715523.4149199834	6254897.5603188	4282912.67963475	3832568.37667092	4790126.20554149	1139246.15986255	2002609.64313824	1209098.21921722	1450318.0074060035
Cont_P02533	Keratin, type I cytoskeletal 14 OS=Homo sapiens OX=9606 GN=KRT14 PE=1 SV=4	164.831	58	26	684	9	472	51.5	cell organization and biogenesis;other biological processes	plasma membrane;cytosol;cytoskeleton;nucleus;other cell component	cytoskeletal activity;other molecular function	3861	ENSG00000186847	KRT14	hsa:3861; P02533; Q14715; Q53XY3; Q9BUE3; Q9UBN2; Q9UBN3; Q9UCY4	Corticotropin-releasing hormone signaling	Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin; Developmental Lineage of Mammary Gland Myoepithelial Cells; Type I hemidesmosome assembly	0.821333803243143	0.880930298968675	0.666244110962191	0.887279041944908	0.735573385767802	0.728871118050286	0.645534074006669	1.76226512549596E-4	6033554.14310828	6671959.15781397	7782964.06135275	6829492.454091667	8837829.92566611	1.15627425945257E7	9278023.72116937	9892865.41378706	1.41062299354562E7	8950994.20838312	7841743.81261716	1.0299655985485494E7	1.15454726530467E7	7260451.91646668	9574113.2223773	9460012.597296894	2.05703168301172E7	1.34402077310531E7	5.39893889957522E7	2.9333304518974166E7
P11499	Heat shock protein HSP 90-beta [OS=Mus musculus]	164.719	50	29	532	19	724	83.2	cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes	non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component	enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function	15516	ENSMUSG00000023944	Hsp90ab1	mmu:15516; O89078; P11499; Q3UIQ7	Focal adhesion: PI3K-Akt-mTOR signaling pathway	Neutrophil degranulation; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of actin dynamics for phagocytic cup formation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Attenuation phase; Estrogen-dependent gene expression; Sema3A PAK dependent Axon repulsion; Aryl hydrocarbon receptor signalling; DDX58/IFIH1-mediated induction of interferon-alpha/beta; HSF1 activation; RHOBTB2 GTPase cycle; The NLRP3 inflammasome	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.952333191127893	0.385192173946943	0.975071223710592	0.476079393565723	221410.585638305	129165.68527882	147525.692220339	166033.98771248801	3.34627647115336E7	3.61961534999558E7	2.61391308788083E7	3.193268303009924E7	9541203.16877468	9273367.56835581	1.36082703259873E7	1.0807613687705928E7	4.57710434253974E7	4.37708354854306E7	3.73056416942256E7	4.22825068683512E7	7437513.65495311	1.56244060515822E7	1.17622035416132E7	1.1608041082716169E7
Q9JKF1	Ras GTPase-activating-like protein IQGAP1 [OS=Mus musculus]	163.926	28	36	250	36	1657	188.6	cell organization and biogenesis;developmental processes;signal transduction;other biological processes	plasma membrane;other membranes;cytoskeleton;nucleus;other cell component	enzyme regulator activity;other molecular function	29875	ENSMUSG00000030536	Iqgap1	G3UW45; mmu:29875; Q9JKF1	G13 signaling pathway; Regulation of actin cytoskeleton	RHO GTPases activate IQGAPs; Neutrophil degranulation; RAC1 GTPase cycle; RAC2 GTPase cycle; RHOA GTPase cycle; MAP2K and MAPK activation; RHOQ GTPase cycle; RHOC GTPase cycle; RHOU GTPase cycle; RHOV GTPase cycle; Nephrin family interactions	0.930229675308081	0.794460986683881	0.787568130909409	0.991639536226218	0.830676695521175	0.941920360687835	0.777195460870953	0.924682711624237	49243.316732893	68725.418758499		58984.367745696	969026.209101501	1404075.03080168	833592.785314498	1068898.0084058929	204266.486982725	334218.990287697	455010.844725875	331165.4406654323	4213732.69874793	3933999.53801573	3238797.72524118	3795509.9873349466	503563.00444482	1468565.36197421	860307.289081776	944145.2185002686
P52480	Pyruvate kinase PKM [OS=Mus musculus]	163.393	62	27	442	27	531	57.8	cell organization and biogenesis;other metabolic processes;other biological processes	cytosol;ER/Golgi;nucleus;other cell component	nucleic acid binding activity;kinase activity;other molecular function	18746	ENSMUSG00000032294	Pkm	mmu:18746; P52480; Q3TBV8; Q3TBW5; Q3TC59; Q3U1X3; Q3U5P6; Q4VC20; Q64484; Q91YI8; Q9CWB1	Glycolysis and gluconeogenesis; Purine metabolism	Neutrophil degranulation; Pyruvate metabolism; Glycolysis; Regulation of pyruvate metabolism	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.938859506774495	0.972868731003358	0.958705855138011	0.959522188921769	312569.127047718	79336.1029165598	280190.614862653	224031.9482756436	2.13357824001936E7	1.96436562290884E7	9081648.29120601	1.6687028973496003E7	1.01259485831113E7	9467201.29798786	1.55257573035923E7	1.1706302394897154E7	3.31547939620584E7	3.43565739025104E7	2.75852274417617E7	3.1698865102110166E7	7722776.69094361	1.86748082798887E7	1.43901632993649E7	1.3595916090065738E7
P63017	Heat shock cognate 71 kDa protein [OS=Mus musculus]	161.557	53	28	572	23	646	70.8	cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;other biological processes	non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component	signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function	15481	ENSMUSG00000015656	Hspa8	mmu:15481; P08109; P12225; P63017; Q3U6R0; Q3U764; Q3U7D7; Q3U7E2; Q3U9B4; Q3U9G0; Q3UGM0; Q5FWJ6; Q62373; Q62374; Q62375; Q6NZD0	Mapk signaling pathway; Exercise-induced circadian regulation	Neutrophil degranulation; mRNA Splicing - Major Pathway; Regulation of HSF1-mediated heat shock response; PKR-mediated signaling; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis; Attenuation phase; Lysosome Vesicle Biogenesis; GABA synthesis, release, reuptake and degradation; AUF1 (hnRNP D0) binds and destabilizes mRNA; Protein methylation	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.987939278265184	0.953011140807089	0.709593139419252	0.587315224195015	247063.168316828	221267.865667273	228333.997143376	232221.67704249235	2.34302361722569E7	1.91610816116977E7	2.44529780700925E7	2.2348098618015703E7	1.52458610795295E7	1.21057626921531E7	1.98188188374949E7	1.5723480869725833E7	4.35786305197153E7	3.523488629513E7	2.44125225303247E7	3.440867978172333E7	9679200.3009757	1.32405397257932E7	1.30838270231471E7	1.2001189016638666E7
Q9JHU4	Cytoplasmic dynein 1 heavy chain 1 [OS=Mus musculus]	161.009	14	55	258	55	4644	531.7	cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes	cytoskeleton;other cell component	cytoskeletal activity;other molecular function	13424	ENSMUSG00000018707	Dync1h1	E9QM71; mmu:13424; Q9JHU4		MHC class II antigen presentation; Neutrophil degranulation; Separation of Sister Chromatids; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; COPI-mediated anterograde transport; Recruitment of NuMA to mitotic centrosomes; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-independent Golgi-to-ER retrograde traffic; Aggrephagy; Anchoring of the basal body to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; AURKA Activation by TPX2	0.591873375996003	0.826895204418257	0.758743075163871	0.936818656936794	0.771389136401717	0.987352798667733	0.695927216301667	0.953305976192702	224060.75101347	288932.991027563	370866.333925136	294620.0253220563	1035717.43113769	1898525.78207622	892363.147243056	1275535.4534856554	298543.620628635	395801.785314415	659710.172961205	451351.8596347517	5741364.17159479	5412980.23144293	4332188.15134028	5162177.518126	1219184.02821873	1626625.47525789	1541170.38578568	1462326.6297541
Q99K41	EMILIN-1 [OS=Mus musculus]	157.011	31	21	244	21	1017	107.5	cell adhesion;cell organization and biogenesis;developmental processes;other biological processes	non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component	signal transduction activity or receptor binding;extracellular structural activity;other molecular function	100952	ENSMUSG00000029163	Emilin1	mmu:100952; Q99K41		Molecules associated with elastic fibres	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.169879542413978	0.64186124184599	0.0921665663508908	0.491906845171331					6287128.66260445	6034831.78772075	4173278.84836641	5498413.09956387	1744058.35010072	1513530.29654839	1757558.94039384	1671715.86234765	2698540.13579468	2559754.7470142	1836473.80243277	2364922.89508055	286714.652107864	495091.120602366	371444.218276851	384416.66366236034
Q61879	Myosin-10 [OS=Mus musculus]	146	19	31	236	20	1976	228.9	cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes	plasma membrane;other membranes;cytosol;cytoskeleton;other cell component	cytoskeletal activity;nucleic acid binding activity;other molecular function	77579	ENSMUSG00000020900	Myh10	mmu:77579; Q5SV63; Q61879	Regulation of actin cytoskeleton	RHO GTPases activate PAKs	0.705689538076567	0.506231596289679	0.676239752697828	0.933545599871938	0.996007724449986	0.990096171400123	0.953146340313072	0.921444667457376	132922.802732814	81410.1821075416	155803.703539863	123378.89612673952	578601.376274227	569525.366217458	228469.06472958	458865.269073755	249877.75631	195698.454667987	352494.602688902	266023.60455562966	1222751.03080206	1020719.46631895	1025108.65415173	1089526.38375758	489393.525760184	539451.948957579	659882.564109888	562909.3462758837
Cont_P00761	Trypsin OS=Sus scrofa OX=9823 PE=1 SV=1	143.502	62	11	3859	10	231	24.4	protein metabolism;other biological processes	non-structural extracellular	other molecular function							0.254996071775817	0.172153475402034	0.357784551188889	0.34040294575649	0.822223648478518	0.740968241512781	0.960577895552113	0.148582186670595	5.17896971017178E9	5.13317471139103E9	7.27761160813741E9	5.863252009900073E9	2.70973552724487E9	1.73168232498425E9	2.0962236592694E9	2.1792138371661735E9	3.08554430734093E9	3.85764460784296E9	3.06099934235171E9	3.334729419178533E9	1.42194297351806E9	1.8379662886425E9	3.81973460995747E9	2.35988129070601E9	5.3849654871275E9	2.81761370832162E9	5.23567407489624E9	4.479417756781787E9
P20029	Endoplasmic reticulum chaperone BiP [OS=Mus musculus]	142.966	48	25	434	23	655	72.4	protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes	non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component	enzyme regulator activity;translation activity;other molecular function	14828	ENSMUSG00000026864	Hspa5	mmu:14828; O35642; P20029; Q3UFF2; Q61630	Mapk signaling pathway	Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Regulation of HSF1-mediated heat shock response	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.916283277860523	0.769590657123576	0.985707795620743	0.888702680095366					7850142.93480902	7648809.53150357	9169945.31743656	8222965.927916382	7535475.80605118	5802650.52918468	8839942.11003441	7392689.481756757	1.89485602512479E7	1.6006905998567E7	1.24118184289709E7	1.57890948929286E7	7216046.0503345	9459779.49149077	8533209.24248049	8403011.594768586
Cont_P13647	Keratin, type II cytoskeletal 5 OS=Homo sapiens OX=9606 GN=KRT5 PE=1 SV=3	142.395	51	34	500	20	590	62.3	cell organization and biogenesis;other biological processes	cytosol;cytoskeleton;other cell component	bone, tooth or skin structural activity;cytoskeletal activity;other molecular function	3852	ENSG00000186081	KRT5	hsa:3852; P13647; Q6PI71; Q6UBJ0; Q8TA91		Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin; Developmental Lineage of Mammary Stem Cells; Developmental Lineage of Mammary Gland Myoepithelial Cells; Type I hemidesmosome assembly	0.786915923361782	0.847457711018997	0.707170943024881	0.746833150482801	0.873755746039336	0.714156118974909	0.2733017775894	2.49132633766938E-5	5120503.46953844	5171426.92187225	6553368.21772984	5615099.536380176	9669299.63907403	1.1127930529353E7	9127716.50969809	9974982.226041706	9513581.76230213	7584977.17814252	6506980.60696686	7868513.182470503	1.59683716443188E7	1.28154121523541E7	1.32126695164861E7	1.3998817771053001E7	1.8678004759752E7	1.36191738010446E7	5.39600661696836E7	2.8752414910160065E7
Cont_P08779	Keratin, type I cytoskeletal 16 OS=Homo sapiens OX=9606 GN=KRT16 PE=1 SV=4	140.751	54	25	569	12	473	51.2	cell organization and biogenesis;stress response;other biological processes	plasma membrane;cytosol;cytoskeleton	cytoskeletal activity	3868	ENSG00000186832	KRT16	A8K488; hsa:3868; P08779; P30654; Q16402; Q9UBG8	Vitamin D receptor pathway	Formation of the cornified envelope	0.941324060398065	0.961351301268194	0.761460393544015	0.887279041944908	0.82543231800733	0.493923182294169	0.895302208460818	3.1065941501805E-4	1047544.82178002	1389728.97312405	1389730.63830375	1275668.1444026066	1501449.09449526	2307427.01338473	2939547.44501319	2249474.51763106	7196685.12946156	1715910.61220057	2812173.28112121	3908256.3409277797	4331979.12309994	1639569.64130669	1737373.70058763	2569640.8216647534	4434008.92515372	2223613.02167429	9547147.41410007	5401589.786976026
Cont_P02465	Collagen alpha-2(I) chain OS=Bos taurus OX=9913 GN=COL1A2 PE=1 SV=2	139.99	18	19	445	3	1364	129		non-structural extracellular;extracellular matrix	extracellular structural activity;other molecular function	282188	ENSBTAG00000013472	COL1A2	A6QP13; bta:282188; O62649; P02465	Inflammatory response pathway; Focal adhesion	Fibronectin matrix formation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Collagen degradation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; Collagen chain trimerization; GPVI-mediated activation cascade; Platelet Aggregation (Plug Formation); Platelet Adhesion to exposed collagen; GP1b-IX-V activation signalling	0.483779141493222	0.876027096029978	0.421836754550416	0.488872343346086	0.731850662833984	0.076245756040016	0.549852418071669	0.432748651973214	80849.8235508145	93725.5578519836	35755.9745173747	70110.45197339094	170240.553800628	153570.468872413	167384.810476394	163731.944383145	78292.6458688874	70345.2867467554	108688.239366299	85775.39066064726	65032.7123193958	48396.6073357386	51482.0177898574	54970.44581499727	51011.1923790395	62191.0072542807	32903.9376967684	48702.045776696206
Cont_P12763	Alpha-2-HS-glycoprotein OS=Bos taurus OX=9913 GN=AHSG PE=1 SV=2	132.772	50	16	1191	16	359	38.4	stress response;other biological processes	non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component	enzyme regulator activity	280988		AHSG	A6QLF7; bta:280988; P12763		Neutrophil degranulation; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation	0.573667790345329	0.793013134473823	0.624272910267193	0.36488675645736	0.946568086066385	0.268930374946741	0.335956814949331	0.913214993335179	6.75081036645858E8	9.56771805796805E8	4.32862555462728E8	6.882384659684638E8	6.04790296716478E8	6.42824998486085E8	6.76887564991134E8	6.41500953397899E8	8.54466282868744E8	8.4303805016043E8	9.16216503216691E8	8.712402787486216E8	7.41908408260606E8	7.48114705273509E8	6.29285280642112E8	7.064361313920757E8	3.42283489676807E8	6.64083343401506E8	3.25834950231514E8	4.440672611032756E8
P07901	Heat shock protein HSP 90-alpha [OS=Mus musculus]	132.382	43	25	402	16	733	84.7	cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes	plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component	signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function	15519	ENSMUSG00000021270	Hsp90aa1	mmu:15519; P07901	EBV LMP1 signaling; Focal adhesion: PI3K-Akt-mTOR signaling pathway; IL-6 signaling pathway; IL-2 signaling pathway	Regulation of necroptotic cell death; Recruitment of NuMA to mitotic centrosomes; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of actin dynamics for phagocytic cup formation; Neutrophil degranulation; Downregulation of ERBB2 signaling; Anchoring of the basal body to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; AURKA Activation by TPX2; Extra-nuclear estrogen signaling; Attenuation phase; Estrogen-dependent gene expression; Sema3A PAK dependent Axon repulsion; VEGFR2 mediated vascular permeability; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation; DDX58/IFIH1-mediated induction of interferon-alpha/beta; eNOS activation; HSF1 activation; RHOBTB2 GTPase cycle; Drug-mediated inhibition of ERBB2 signaling	1.65082956259427E-17	0.508730894200713	1.50457038391225E-17	0.251664970734015	0.974827674952665	0.788764875934969	0.968364585136618	0.745600589176001	51071.3130902855	169244.190500369	193833.457176882	138049.65358917884	3826029.08230807	4600695.96516161	3479662.10980986	3968795.71909318	1533159.7098775	1700635.66665037	1768278.53880507	1667357.9717776468	6471421.59388824	6122550.53993506	5450079.38924241	6014683.841021903	900341.190737514	2215799.13247972	1704183.40484156	1606774.576019598
Q02819	Nucleobindin-1 [OS=Mus musculus]	131.152	51	21	299	21	459	53.4	signal transduction	non-structural extracellular;other membranes;ER/Golgi	enzyme regulator activity;nucleic acid binding activity;other molecular function	18220	ENSMUSG00000030824	Nucb1	mmu:18220; Q02819; Q3TU42; Q9CWA1; Q9D8J4; Q9DBL3		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	0.130903496983571	0.0679830640731695	0.340647566778883	0.397987186613988	0.958122559708965	41072.7931792495		20198.6046706008	30635.69892492515	1.70846710933602E7	1.97547416617741E7	2.08807433533847E7	1.9240052036173E7	5757191.6972993	4828078.95450858	5895038.38978249	5493436.34719679	7136546.74332753	7387752.88718417	5120327.81590923	6548209.148806977	1130733.36645935	3369667.63744922	2637872.59598673	2379424.5332984333
Q91V92	ATP-citrate synthase [OS=Mus musculus]	129.973	32	28	237	28	1091	119.7	other metabolic processes	cytosol	other molecular function	104112	ENSMUSG00000020917	Acly	mmu:104112; Q91V92	Fatty acid biosynthesis	Neutrophil degranulation; Fatty acyl-CoA biosynthesis	0.230775890814232	0.371468864113786	0.437429424171984	0.509570119936397	0.626059420687734	0.98558531112136	0.643183834410259	0.922580167429744	8856.99380706579	32765.2400642807	40990.0091117865	27537.414327710998	2382723.31982566	2481678.51703659	2154876.39410613	2339759.4103227933	1256305.5375454	885993.369046538	1688459.92743218	1276919.6113413726	2057502.05407172	1815562.79058184	1460220.9588277	1777761.9344937534	534991.757912276	802971.776166877	594587.914542531	644183.8162072281
A2ASQ1	Agrin [OS=Mus musculus]	128.989	18	26	227	26	1950	207.4	cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes	non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cell component	signal transduction activity or receptor binding;other molecular function	11603	ENSMUSG00000041936	Agrn	A2ASP9; A2ASQ0; A2ASQ1; B2RWU1	Primary focal segmental glomerulosclerosis (FSGS)	ECM proteoglycans; Retinoid metabolism and transport; Glycosaminoglycan-protein linkage region biosynthesis; HS-GAG biosynthesis; HS-GAG degradation; Formation of the dystrophin-glycoprotein complex (DGC)	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.460727828548759	0.972791368602389	0.686318824668434	0.846971399004193					2612028.52511147	3116500.52541199	3328171.1398056	3018900.06344302	1818519.74579979	1551006.46226864	1715477.48863677	1695001.2322350666	2313945.16119856	2044906.61336417	1778324.63596447	2045725.4701757336	632566.873707257	1496109.18442141	957812.214242183	1028829.4241236168
Q61508	Extracellular matrix protein 1 [OS=Mus musculus]	127.379	45	18	358	18	559	62.8	stress response;developmental processes;signal transduction;other biological processes	non-structural extracellular	signal transduction activity or receptor binding;other molecular function	13601	ENSMUSG00000028108	Ecm1	mmu:13601; Q3U5Q5; Q61508		Platelet degranulation	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	0.121600547823456	2.27890527565265E-4	0.795351011232032	1.51989274634622E-7	0.592370654746194	110159.96586707	68619.5270607555	45654.6843175291	74811.39241511819	5.6443097497098E7	7.11751205740166E7	5.82782830048746E7	6.196550035866306E7	5.1935854689884E7	4.50204039942893E7	5.70225374161979E7	5.132626536679041E7	1.27540105597053E7	1.25514774649527E7	8690203.83604475	1.1331897286900917E7	2192350.97546663	4663417.73981907	3690111.31703252	3515293.344106073
Cont_P04259	Keratin, type II cytoskeletal 6B OS=Homo sapiens OX=9606 GN=KRT6B PE=1 SV=5	126.901	47	30	442	4	564	60	cell organization and biogenesis;other biological processes	cytosol;cytoskeleton	bone, tooth or skin structural activity;cytoskeletal activity	3854	ENSG00000185479	KRT6B	hsa:3854; P04259; P48669		Formation of the cornified envelope	0.857251372850113	0.868132360832926	0.758743075163871	0.801271130817871	0.854305439376382	0.340133476321195	0.937453377971347	0.00123883404563536	267279.779286483	355493.362381868	274137.281616349	298970.1410949	326989.588402741	585438.697100962	617622.938974811	510017.07482617133	2390973.53573307	430931.486741926	646270.614315847	1156058.5455969477	1869779.42318807	346417.77494154	348508.009299423	854901.7358096777	1155463.67620058	538093.594898596	1653754.7898307	1115770.6869766254
P17182	Alpha-enolase [OS=Mus musculus]	126.804	60	19	244	16	434	47.1	other metabolic processes;developmental processes;other biological processes	plasma membrane;other membranes;cytosol;other cell component	nucleic acid binding activity;other molecular function	13806; 433182	ENSMUSG00000059040; ENSMUSG00000063524	Eno1	mmu:13806; mmu:433182; P17182; Q99KT7; Q9DCY7	Glycolysis and gluconeogenesis		1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.720832939248489	0.789540446904924	0.858218537342417	0.989544231571828	31098.019126098	70318.9502605952	40658.6319347469	47358.53377381337	1.28655809626545E7	1.34726279447959E7	7101469.5445256	1.1146559483992001E7	9089751.86845938	7552189.93174957	1.17772011823713E7	9473047.660860082	3.50544676757808E7	2.99447661492486E7	2.18255690502528E7	2.89416009584274E7	1.11532480577619E7	1.75489228796712E7	1.30151947674988E7	1.3905788568310633E7
P08113	Endoplasmin [OS=Mus musculus]	126.346	39	26	329	25	802	92.4	cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes	non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cell component	signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function	22027	ENSMUSG00000020048	Hsp90b1	mmu:22027; P08113; P11427	Focal adhesion: PI3K-Akt-mTOR signaling pathway; Hypoxia-dependent self-renewal of myoblasts	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Scavenging by Class A Receptors; Trafficking and processing of endosomal TLR; Interleukin-4 and Interleukin-13 signaling	0.107476768049312	0.0104456807471941	1.50457038391225E-17	0.205304099107124	0.854305439376382	0.840785133352029	0.866766165039268	0.896996950298791	75656.6139115948	52183.5314261123	29905.9702816436	52582.03853978356	5932785.14172209	5786569.94317903	3299962.37110113	5006439.15200075	3817668.17887426	3366255.7650389	4907428.60350699	4030450.84914005	1.47606948013545E7	1.21020755462977E7	1.0441016038914E7	1.2434595462188734E7	3792376.91369813	7854793.82920015	6464144.86133097	6037105.20140975
P58252	Elongation factor 2 [OS=Mus musculus]	126.048	37	31	378	30	858	95.3	cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes	plasma membrane;other membranes;cytosol;translational apparatus;other cell component	cytoskeletal activity;translation activity;nucleic acid binding activity;other molecular function	13629	ENSMUSG00000034994	Eef2	mmu:13629; P58252; Q544E4	Translation factors	Neutrophil degranulation; Protein methylation; Peptide chain elongation; Synthesis of diphthamide-EEF2	0.299809054080284	0.188334321166369	0.471929633209224	0.84258396038376	0.922179983282929	0.97504218639442	0.866546043492515	0.950878070645738	275529.241689771	247076.7728808	166294.142173825	229633.38558146535	1.22498155967913E7	1.26488626480754E7	6800245.14611723	1.0566307796994643E7	5717562.35282925	5172569.64432748	8352282.82529915	6414138.274151959	1.55667000517401E7	1.33925688878402E7	1.02378508629272E7	1.3065706600835832E7	2972661.18095993	6421886.97759523	5184391.52691505	4859646.5618234025
Cont_P02538	Keratin, type II cytoskeletal 6A OS=Homo sapiens OX=9606 GN=KRT6A PE=1 SV=3	123.757	47	30	454	3	564	60	cell organization and biogenesis;stress response;other biological processes	cytosol;cytoskeleton	bone, tooth or skin structural activity;cytoskeletal activity	3853	ENSG00000205420	KRT6A	A4QPC1; hsa:3853; P02538; P48667; Q08AR4; Q6NT67; Q96CL4	Ectoderm differentiation; Ectoderm differentiation; Pancreatic cancer subtypes	Formation of the cornified envelope	0.892533464536408	0.964633336683333	0.745886066139481	0.84258396038376	0.792564971776066	0.574739141583974	0.709593139419252	5.66461038960431E-4	2017098.82314832	2171650.09464557	2359880.73116726	2182876.549653717	2825309.68904382	4320098.03084773	4192074.59940388	3779160.7730984767	8075888.41129776	2685265.07688442	3594101.84504227	4785085.111074816	5878699.8667026	3215829.01184206	2854010.96069105	3982846.61307857	8158147.16608847	4198498.19802621	1.30998597349634E7	8485501.699692694
P97298	Pigment epithelium-derived factor [OS=Mus musculus]	123.502	47	16	346	12	417	46.2	cell cycle OR cell proliferation;developmental processes;other biological processes	non-structural extracellular;extracellular matrix;other cell component	enzyme regulator activity	20317	ENSMUSG00000000753	Serpinf1	mmu:20317; O70629; O88691; P97298			1.65082956259427E-17	0.227296093012204	0.434748506750565	0.770205086382264	0.00901230529014985	0.174886032348437	0.300753028734261	0.891044455497809	554016.1710638	470705.490372182	363015.858993357	462579.17347644636	5.24905837082578E7	7.20656975211191E7	8.90978835263609E7	7.121805491857927E7	1.55195541438312E7	1.33807646088142E7	1.504676823338E7	1.46490289953418E7	1.63245792137601E7	1.5700230598517E7	1.5246806329463E7	1.5757205380580032E7	3869051.7420588	8996988.40278734	4897006.93274029	5921015.69252881
Q70E20	Sushi, nidogen and EGF-like domain-containing protein 1 [OS=Mus musculus]	122.942	19	22	287	22	1403	151.5	cell adhesion	non-structural extracellular;extracellular matrix	other molecular function	208777		Sned1	A6H6I3; mmu:208777; Q70E20; Q810H2; Q8BMD9			1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.889058672589993	0.869908412860824	0.817293288705596	0.880760468933162	62940.5062355012	25184.2741656831	25459.8187779288	37861.533059704365	7879183.70581794	8304827.25748066	2617617.70526214	6267209.5561869135	3110990.0320528	3263544.92621848	3507274.08693078	3293936.3484006864	1.72480350493842E7	1.48489121993504E7	1.05732378776404E7	1.4223395042125002E7	2537287.1447922	7075122.99473268	5373074.41423662	4995161.517920501
P13020	Gelsolin [OS=Mus musculus]	122.934	35	22	377	9	780	85.9	cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes	non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component	cytoskeletal activity;other molecular function	227753	ENSMUSG00000026879	Gsn	mmu:227753; P13020; Q3UPB1; Q8R590	Regulation of actin cytoskeleton	Neutrophil degranulation; Caspase-mediated cleavage of cytoskeletal proteins	0.440427841758307	0.396306424610341	0.186266168629733	0.379422692457324	0.65414435708462	0.994546642862744	0.709593139419252	0.793590033024783	1154075.61374729	1486973.5078743	778278.604931373	1139775.9088509877	1.0611315000974E7	9755419.92114226	9110194.21443976	9825643.045518672	6039243.17546894	5549542.61366164	7725308.54354706	6438031.44422588	3.63344365935893E7	2.77403609084757E7	2.33574049877416E7	2.9144067496602204E7	8417203.0170929	1.43392014575414E7	1.03453705657478E7	1.1033925013460701E7
Q61398	Procollagen C-endopeptidase enhancer 1 [OS=Mus musculus]	120.4	40	14	323	14	468	50.1	protein metabolism;other biological processes		enzyme regulator activity;other molecular function	18542	ENSMUSG00000029718	Pcolce	mmu:18542; O35113; Q61398	mRNA processing	Collagen biosynthesis and modifying enzymes; Crosslinking of collagen fibrils	1.65082956259427E-17	1.8644578313253E-17	0.151224536345852	0.288320039261486	0.133905327763598	0.789540446904924	0.0895861566882082	0.711902858921665	55825.2363051742	84655.3590880939	113029.200120433	84503.2651712337	3.10244208090572E7	2.97623271730106E7	2.79757713270171E7	2.958750643636163E7	2.72578314339105E7	2.28908828526637E7	2.54654481194513E7	2.52047208020085E7	1.54882233602667E7	1.24902767859117E7	9636426.2851997	1.2538308810459368E7	5125325.32901055	9907837.52014591	7984547.74798259	7672570.19904635
P26039	Talin-1 [OS=Mus musculus]	118.226	15	30	153	30	2541	269.7	cell adhesion;cell organization and biogenesis;signal transduction	plasma membrane;other membranes;cytosol;cytoskeleton;other cell component	signal transduction activity or receptor binding;cytoskeletal activity;other molecular function	21894	ENSMUSG00000028465	Tln1	A2AIM8; mmu:21894; P26039; Q8VEF0	Primary focal segmental glomerulosclerosis (FSGS); Integrin-mediated cell adhesion; Focal adhesion	Platelet degranulation ; MAP2K and MAPK activation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; Smooth Muscle Contraction; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	0.958262397335385	0.994542145304377	0.680632778351053	0.738983404380581	0.850917681937748	0.783910800136359	0.87222702623065	0.535066779633529	137218.697336797	64798.4580467583	241653.653741064	147890.2697082064	580168.664793601	803244.58151111	320387.746187394	567933.664164035	118081.406885094	124079.798936285	255551.526824265	165904.24421521465	2877993.84785898	2114900.66089323	1881659.61273992	2291518.0404973766	240671.449108311	385063.079961369	234819.255172709	286851.2614141297
Q8BPB5	EGF-containing fibulin-like extracellular matrix protein 1 [OS=Mus musculus]	117.738	49	15	220	15	493	54.9	protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes	extracellular matrix	signal transduction activity or receptor binding;kinase activity;other molecular function	216616	ENSMUSG00000020467	Efemp1	mmu:216616; Q6Y3N6; Q8BPB5			1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	0.376780684027729	0.278244203695445	0.983440558239231	0.145805028390539	0.982581944728745	15298.8221438323	19141.8575027524	55545.7753728227	29995.485006469138	7090020.68988726	8805500.10345141	5126350.07183034	7007290.288389671	4435222.67421531	4392813.74676133	4496081.41897935	4441372.613318663	4016966.57007158	3984703.05528875	2817881.79753384	3606517.1409647237	682456.349264741	1966499.77195883	1462163.85427198	1370373.3251651835
P09411	Phosphoglycerate kinase 1 [OS=Mus musculus]	116.462	57	18	287	18	417	44.5	protein metabolism;other metabolic processes;stress response;other biological processes	non-structural extracellular;other membranes;cytosol;mitochondrion;other cell component	kinase activity;other molecular function	18655	ENSMUSG00000062070	Pgk1	mmu:18655; P09411; Q3TPE6; Q3UKV8; Q5XJE7	Glycolysis and gluconeogenesis	Gluconeogenesis; Glycolysis	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.465126095372736	0.766862952867809	0.820281310709571	0.891044455497809	78089.4641074341	38741.0917691314	23421.0514741904	46750.53578358531	4316274.39280249	5023293.68471847	1442874.888393	3594147.655304653	2829873.33459098	2934698.045784	3868274.47312523	3210948.6178334034	1.65254946701665E7	1.56270051770472E7	1.22346365889796E7	1.4795712145397767E7	2315853.03926933	6654180.61411261	4530199.20599689	4500077.619792943
P27773	Protein disulfide-isomerase A3 [OS=Mus musculus]	115.891	55	23	291	23	505	56.6	cell adhesion;cell organization and biogenesis;stress response;signal transduction;other biological processes	non-structural extracellular;other membranes;ER/Golgi;other cell component	nucleic acid binding activity;other molecular function	14827	ENSMUSG00000027248	Pdia3	mmu:14827; P27773; Q3TEI9; Q3TIL2; Q3UZK8; Q8C2F4; Q99LF6		ER-Phagosome pathway; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Calnexin/calreticulin cycle	0.9135584231482	0.736536116100563	0.498293621965442	0.874168055361729	0.850917681937748	0.862063111456553	0.881496352314601	0.939046770372612	206281.038958907	253939.7116523	128510.108086966	196243.61956605766	6669793.66068216	7133803.24141356	5637352.69437344	6480316.532156386	5319375.96186612	3844376.07822282	6321729.00885173	5161827.016313557	1.83298906806341E7	1.50101054148645E7	1.26051366299531E7	1.5315044241817234E7	6059857.55300524	8984695.03809976	6670485.36185494	7238345.98431998
P10107	Annexin A1 [OS=Mus musculus]	115.566	64	18	270	18	346	38.7	cell organization and biogenesis;stress response;transport;signal transduction;other biological processes	non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component	enzyme regulator activity;other molecular function	16952	ENSMUSG00000024659	Anxa1	mmu:16952; P10107	Spinal cord injury; Prostaglandin synthesis and regulation	G alpha (q) signalling events; G alpha (i) signalling events; Formyl peptide receptors bind formyl peptides and many other ligands	1.65082956259427E-17	0.105053536950499	1.50457038391225E-17	1.70336894001643E-17	0.954328834404239	0.401885831342676	0.529099828181544	0.924766494197286	13280.9290610842	9160.53166722029	4508.77124840677	8983.410658903753	5251880.61554565	6740833.31198439	6058745.6526555	6017153.19339518	1560362.01883491	1521121.84391776	1946127.08618424	1675870.316312303	1.11990207127477E7	1.0990927807692E7	1.0321301103113E7	1.08370832078509E7	3223846.7434476	4805492.80063037	4605609.45936174	4211649.667813237
Cont_Q2KJF1	Alpha-1B-glycoprotein OS=Bos taurus OX=9913 GN=A1BG PE=1 SV=1	115.502	48	14	224	14	503	53.5	signal transduction	non-structural extracellular;plasma membrane;other membranes		518955		A1BG	bta:518955; Q2KJF1		Platelet degranulation ; Neutrophil degranulation	0.635218461842139	0.655487072215252	0.641514600397631	0.360991986803736	0.932231143665149	0.696358249006924	0.601376052147163	0.891044455497809	1.12339445909494E7	1.09217008752481E7	5999938.28834399	9385194.584847162	7597724.26810103	8696294.29830821	1.02832125493257E7	8859077.038578315	1.08372253099689E7	9914324.88654618	8710997.51604168	9820849.23751892	1.11963323092602E7	9450705.94975847	1.03053408353504E7	1.0317459698123023E7	5535891.07899516	9467766.08082133	5283853.74244175	6762503.63408608
Cont_Q3MHN5	Vitamin D-binding protein OS=Bos taurus OX=9913 GN=GC PE=2 SV=1	113.599	55	20	319	20	474	53.3	other metabolic processes;transport	non-structural extracellular;other cell component	transporter activity;cytoskeletal activity;other molecular function	530076		GC	bta:530076; Q3MHN5			0.549057967251154	0.804331105646976	0.579435037816218	0.479472599858427	0.946173787415917	0.139718417146003	0.570795727084329	0.421365656927814	1.55879441314789E7	1.53074066841615E7	7458694.29508707	1.2784681703575822E7	1.04365108192777E7	1.20620475306269E7	8309099.82300618	1.026921939097026E7	1.67215053413279E7	1.54231806136738E7	1.57780518794517E7	1.5974245944817802E7	1.6556516146824E7	1.52311500265876E7	1.20681229464E7	1.4618596373270534E7	9478628.98672491	1.47438110125204E7	8133055.93664235	1.0785165311962552E7
P17742	Peptidyl-prolyl cis-trans isomerase A [OS=Mus musculus]	113.527	60	9	369	9	164	18	cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes	non-structural extracellular;cytosol;nucleus;other cell component	signal transduction activity or receptor binding;other molecular function	268373	ENSMUSG00000071866	Ppia	mmu:268373; P17742; Q9CWJ5; Q9R137		Neutrophil degranulation; Basigin interactions	0.100219677394751	0.099382125133403	1.50457038391225E-17	1.70336894001643E-17	0.946239447314336	0.696358249006924	0.937453377971347	0.331144967260478	1.16891341386391E7	754837.409863468	4157779.88062054	5533917.143041036	2.9189343463191E7	2.94929696895869E7	4.96473559496876E7	3.610988970082183E7	1.04342545713823E7	8178713.43858634	1.18234267071803E7	1.0145464905716315E7	4.91534751033825E7	4.2865019365108E7	4.61937263356195E7	4.607074026803666E7	7275434.18699702	1.51319991253865E7	9682919.1999608	1.0696784170781441E7
Q69ZN7	Myoferlin [OS=Mus musculus]	112.647	22	36	227	36	2048	233.2	cell organization and biogenesis;other metabolic processes;stress response;other biological processes	plasma membrane;other membranes;nucleus	other molecular function	226101	ENSMUSG00000048612	Myof	mmu:226101; Q69ZN7; Q7TMG0; Q80V33; Q8BU64; Q8BU70; Q8BUC1; Q8BVY6; Q8C0D1; Q8R3B4			0.73657372909066	0.964709887217926	0.888974672311279	0.930955411749965	0.816275429153737	0.877818946381645	0.609903091678244	0.975029032316037	86000.3771233404	87234.2597428081	50456.7230101595	74563.786625436	780930.944201502	985609.680593147	968573.73043394	911704.7850761963	296294.389327177	289800.794039455	380995.072506467	322363.41862436634	3324626.35891918	3238695.05806667	2634093.62813707	3065805.015040973	993761.586050851	1295229.11918404	1025817.2029614	1104935.9693987637
P26041	Moesin [OS=Mus musculus]	112.068	47	28	353	19	577	67.7	cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes	plasma membrane;other membranes;cytosol;cytoskeleton;other cell component	signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function	17698	ENSMUSG00000031207	Msn	B1AX70; mmu:17698; P26041; Q3UL28; Q8BSN4	Regulation of actin cytoskeleton	Recycling pathway of L1	1.65082956259427E-17	0.0604972675946614	1.50457038391225E-17	0.157138696252226	0.910750689050232	0.682171843898269	0.97925982662951	0.954396180425051	3509434.20481405	4360753.56845675	2823311.97478394	3564499.916018247	1.57847182977139E7	1.58696599538661E7	1.95033967654703E7	1.7052591672350097E7	8383545.44173348	7552431.53754312	1.1473115873696E7	9136364.2843242	2.43209045148915E7	1.7265255344344E7	1.55060800034236E7	1.9030746620886367E7	1.24969658442338E7	1.31486313258361E7	7954804.76477835	1.120013397828275E7
P05064	Fructose-bisphosphate aldolase A [OS=Mus musculus]	112.015	66	18	261	18	364	39.3	cell organization and biogenesis;other metabolic processes;other biological processes	plasma membrane;other membranes;cytosol;cytoskeleton;other cell component	other molecular function	11674	ENSMUSG00000030695	Aldoa	mmu:11674; P05064	Glycolysis and gluconeogenesis	Platelet degranulation ; Neutrophil degranulation; Gluconeogenesis; Glycolysis	0.101571037453114	0.00616383846364181	1.50457038391225E-17	0.0771819601934254	0.907383519445145	0.828577692034317	0.988377544628277	0.953305976192702	36553.7681309936	18014.3910425567	11156.0078725057	21908.055682018665	5538849.24179232	5285372.3367409	3856062.26656154	4893427.94836492	4263443.39983126	3386915.16711964	5306808.16889341	4319055.57861477	1.24814165546298E7	1.09515793948855E7	8528808.13475854	1.0653934694757948E7	4075248.71161469	5289067.55868911	4192052.54158905	4518789.603964283
B2RQC6	Multifunctional protein CAD [OS=Mus musculus]	111.853	18	32	111	32	2225	243.1	other metabolic processes;stress response;transport;developmental processes;other biological processes	cytosol;nucleus;other cell component	kinase activity;other molecular function	69719	ENSMUSG00000013629	Cad	B2RQC6; B7ZN27; mmu:69719	Mechanisms associated with pluripotency	Pyrimidine biosynthesis	0.69394578118832	0.6681512188534	0.666244110962191	0.963127218853016	0.340675523776301	0.968897093792999	0.798180783050573	0.621633895543644	55886.6384121637	12993.9975368397	34438.2113153553	34439.61575478624	1026045.60319635	1025412.85494839	821784.178770446	957747.5456383955	383358.762218724	322831.339780162	640190.890369534	448793.6641228067	516093.312619156	478923.162373783	363366.537093714	452794.3373622177	110686.677299138	180829.981634378	127462.003140709	139659.55402474166
Q8BND5	Sulfhydryl oxidase 1 [OS=Mus musculus]	111.186	35	22	242	22	748	82.7	cell organization and biogenesis;other biological processes	non-structural extracellular;other membranes;ER/Golgi	other molecular function	104009	ENSMUSG00000033684	Qsox1	mmu:104009; Q3TDY9; Q3TE19; Q3TR29; Q3UEL4; Q8BND5; Q8K041; Q9DBL6		Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Neutrophil degranulation	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	0.162753188077458	0.203109767081086	0.696358249006924	0.331332346840573	0.877612009404373	40119.4404166161		10016.9610840251	25068.200750320597	9134645.28263017	1.19624109837519E7	1.04856878607794E7	1.052758137572049E7	3750508.26959308	3765475.87858746	4032369.19900008	3849451.1157268733	5503994.64256118	5774708.06447186	3841814.38132964	5040172.36278756	1169677.75963505	2786812.01379908	1498357.95430882	1818282.5759143168

100

Accession	Description	Sum PEP Score	Coverage [%]	# Peptides	# PSMs	# Unique Peptides	# AAs	MW [kDa]	Biological Process	Cellular Component	Molecular Function	Entrez Gene ID	Ensembl Gene ID	Gene Symbol	Gene ID	WikiPathways	Reactome Pathways	Abundance Ratio Adj. P-Value: (LQ_16h) / (FM)	Abundance Ratio Adj. P-Value: (LQ_6h) / (FM)	Abundance Ratio Adj. P-Value: (SQ_16h) / (FM)	Abundance Ratio Adj. P-Value: (SQ_6h) / (FM)	Abundance Ratio Adj. P-Value: (LQ_16h) / (LQ_6h)	Abundance Ratio Adj. P-Value: (SQ_6h) / (LQ_6h)	Abundance Ratio Adj. P-Value: (SQ_16h) / (SQ_6h)	FM_AVERAGE	LQ6h_AVERAGE	LQ16h_AVERAGE	SQ6h_AVERAGE	SQ16h_AVERAGE
P11276	Fibronectin [OS=Mus musculus]	867.353	58	95	2246	59	2477	272.4	cell adhesion;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes	non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi	signal transduction activity or receptor binding;enzyme regulator activity;other molecular function	14268	ENSMUSG00000026193	Fn1	G5E8B8; mmu:14268; P11276; Q61567; Q61568; Q61569; Q64233; Q80UI4	Focal adhesion: PI3K-Akt-mTOR signaling pathway; Inflammatory response pathway; Regulation of actin cytoskeleton; Comprehensive IL-17A signaling; Focal adhesion	ECM proteoglycans; Platelet degranulation ; Cell surface interactions at the vascular wall; Syndecan interactions; MAP2K and MAPK activation; Integrin cell surface interactions; Molecules associated with elastic fibres; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Fibronectin matrix formation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; Degradation of the extracellular matrix; Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells; MET activates PTK2 signaling; GPER1 signaling	0.0844744457809114	0.00584906503121538	1.50457038391225E-17	0.156115961659409	0.564710097967506	0.435823028559966	0.896613838854506	2.7641453377804603E7	2.022341523870097E8	2.12696235413058E8	1.2629719382404166E8	2.74958241507436E8
P11087	Collagen alpha-1(I) chain [OS=Mus musculus]	797.017	79	75	1933	35	1453	137.9	cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes	non-structural extracellular;extracellular matrix;other cell component	extracellular structural activity;other molecular function	12842	ENSMUSG00000001506	Col1a1	mmu:12842; P11087; Q53WT0; Q60635; Q61367; Q61427; Q63919; Q6PCL3; Q810J9	Osteoblast signaling; Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Comprehensive IL-17A signaling; Focal adhesion	Cell surface interactions at the vascular wall; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ECM proteoglycans; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; GPVI-mediated activation cascade; GP1b-IX-V activation signalling; Platelet Adhesion to exposed collagen; Platelet Aggregation (Plug Formation); MET activates PTK2 signaling	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.381922652011049	0.0629214061377862	0.655833157547641	772438.0834537543	2.0798706453114033E8	5.92854376184685E8	5.973622733379293E7	8.428319253806247E7
Q01149	Collagen alpha-2(I) chain [OS=Mus musculus]	773.662	80	66	1731	51	1372	129.5	cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes	non-structural extracellular;extracellular matrix;other cell component	extracellular structural activity;other molecular function	12843	ENSMUSG00000029661	Col1a2	mmu:12843; Q01149; Q8CGA5	Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Focal adhesion	Crosslinking of collagen fibrils; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; ECM proteoglycans; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; GPVI-mediated activation cascade; GP1b-IX-V activation signalling; Platelet Adhesion to exposed collagen; Platelet Aggregation (Plug Formation); MET activates PTK2 signaling	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.862063111456553	0.0347692006632991	0.926292871155025	182180.3275564673	1.7308392932505235E8	3.475967473053053E8	4.271481968913147E7	9.036410240893161E7
P08121	Collagen alpha-1(III) chain [OS=Mus musculus]	695.631	63	61	1789	51	1464	138.9	cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes	extracellular matrix;other cell component	signal transduction activity or receptor binding;extracellular structural activity;other molecular function	12825	ENSMUSG00000026043	Col3a1	mmu:12825; P08121; Q61429; Q9CRN7	Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Focal adhesion	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ECM proteoglycans; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; MET activates PTK2 signaling	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.0413994480640273	0.394949139624895	0.976852696203657	454748.1180174556	6.282890624937943E7	2.8394661715058166E8	3.0365458724261332E7	6.6157215803336866E7
Q9QXS1	Plectin [OS=Mus musculus]	659.702	46	182	1705	180	4691	533.9	cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes	plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component	cytoskeletal activity;other molecular function	18810	ENSMUSG00000022565	Plec	E9QN87; mmu:18810; Q6S384; Q6S389; Q6S394; Q9CS65; Q9QUT2; Q9QXQ8; Q9QXQ9; Q9QXR0; Q9QXR1; Q9QXR2; Q9QXR3; Q9QXR4; Q9QXR5; Q9QXR6; Q9QXR7; Q9QXR8; Q9QXR9; Q9QXS0; Q9QXS1; Q9QXS2; Q9QXS3	Alpha 6 beta 4 integrin signaling pathway; EGFR1 signaling pathway	Type I hemidesmosome assembly; Caspase-mediated cleavage of cytoskeletal proteins	0.481729871164266	0.714932595871944	0.336550483871782	0.572524806937582	0.532399788858771	0.702330308974487	0.520376293994664	309922.514176982	4599273.114185064	1.6676006673579365E7	1.01501282886872E7	4.28490141732006E7
P08122	Collagen alpha-2(IV) chain [OS=Mus musculus]	526.992	64	69	1077	69	1707	167.2	RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes	non-structural extracellular;extracellular matrix	extracellular structural activity	12827	ENSMUSG00000031503	Col4a2	mmu:12827; P08122; Q3B7C2; Q3TPV9; Q61375; Q66JS5; Q6RCT6; Q6RCT7; Q6U9X1; Q8BPI9; Q8BPK3; Q91VI3	Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Focal adhesion	Laminin interactions; Signaling by PDGF; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions	0.352816378116182	0.64759425713406	0.293387877727491	0.79866917976589	0.169673447599406	0.959159975702413	0.483015668880262	1393534.8123072747	1.3981747232493034E7	5.0194805286054574E7	1.701609057115766E7	5.972856146483746E7
Q3U962	Collagen alpha-2(V) chain [OS=Mus musculus]	518.514	64	57	817	55	1497	144.9	cell organization and biogenesis;developmental processes;other biological processes	extracellular matrix;other cell component	extracellular structural activity;other molecular function	12832	ENSMUSG00000026042	Col5a2	mmu:12832; Q3TVR2; Q3U962; Q3UHK7; Q3UTT4; Q3V1J6; Q61431; Q7TMS0; Q80VS8	Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion	Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions	0.861384746267066	0.961254912149485	0.730324052254867	0.632833892117728	0.273444295895674	0.453486790198347	0.973358018692255	2.4419841082594533E7	1.5753424919239333E7	4.592471970087584E7	1.0471363011153279E7	2.1079551940947264E7
Q05793	Basement membrane-specific heparan sulfate proteoglycan core protein [OS=Mus musculus]	507.28	33	84	998	84	3707	398	cell organization and biogenesis;transport;developmental processes;other biological processes	non-structural extracellular;extracellular matrix;ER/Golgi	other molecular function	15530		Hspg2	mmu:15530; Q05793			0.332090710292395	0.382764581022518	0.771134174410141	0.553652046981626	0.938381933295379	0.285967432697218	0.908661395894721	171009.25706548532	2.1355561683383033E7	4.109385814368304E7	8244737.341084313	1.8998181152407136E7
Q61554	Fibrillin-1 [OS=Mus musculus]	499.202	38	86	1117	86	2873	312.1	cell adhesion;other metabolic processes;developmental processes;signal transduction;other biological processes	non-structural extracellular;extracellular matrix	signal transduction activity or receptor binding;extracellular structural activity;other molecular function	14118	ENSMUSG00000027204	Fbn1	A2AQ53; mmu:14118; Q60826; Q61554	Comprehensive IL-17A signaling	Integrin cell surface interactions; Degradation of the extracellular matrix; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; TGF-beta receptor signaling activates SMADs; Molecules associated with elastic fibres	0.0596853092747711	0.0840496117897429	0.378389090130589	0.84258396038376	0.862063111456553	0.0455630470425967	0.77820123247099	81731.837224874	2.17735814942991E7	5.216417896597137E7	5145074.9913376765	2.082557122129057E7
Q8BTM8	Filamin-A [OS=Mus musculus]	493.069	49	91	915	83	2647	281	cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes	plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component	signal transduction activity or receptor binding;cytoskeletal activity;other molecular function	192176	ENSMUSG00000031328	Flna	B7FAV0; O54934; Q7TQI1; Q8BLK1; Q8BTM8; Q8BTN7; Q8VHX5; Q8VHX8; Q99KQ2	Mapk signaling pathway; Focal adhesion	Platelet degranulation ; Cell-extracellular matrix interactions; RHO GTPases activate PAKs; GP1b-IX-V activation signalling	0.0844935092512095	0.493514006575528	0.170420349138264	0.67528135146603	0.864215513767001	0.904360680536565	0.8468455705593	218480.8558628913	4952287.405198824	1.1395384793048913E7	4296604.098486893	1.4686023116833666E7
P02463	Collagen alpha-1(IV) chain [OS=Mus musculus]	487.707	70	68	828	68	1669	160.6	cell organization and biogenesis;developmental processes;signal transduction;other biological processes	non-structural extracellular;extracellular matrix	extracellular structural activity;other molecular function	12826	ENSMUSG00000031502	Col4a1	mmu:12826; P02463; Q3UHJ4; Q3UJE7; Q3UQV2; Q53X35; Q6GQS7; Q6PHB5; Q99LQ8	Spinal cord injury; Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion	Laminin interactions; Signaling by PDGF; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions	0.604225174343649	0.68008321917751	0.284160251285083	0.936818656936794	0.167300285011781	0.777395712279767	0.224623005929948	262271.417553364	4620515.057112186	2.1463797748519864E7	8911949.32392111	3.3156314746725336E7
Q60847	Collagen alpha-1(XII) chain [OS=Mus musculus]	480.266	40	95	991	95	3120	340	cell adhesion;developmental processes	other cell component		12816	ENSMUSG00000032332	Col12a1	mmu:12816; P70322; Q60847		Assembly of collagen fibrils and other multimeric structures; Collagen chain trimerization; Collagen degradation	0.0975092237649803	1.8644578313253E-17	0.344512840834051	0.162753188077458	0.101350980560035	0.0103905836841461	0.266844028199729	80180.17821443231	5.1736330625803865E7	2.9952489655588504E7	1.0537780206453351E7	1.4629541968462234E7
Q8VDD5	Myosin-9 [OS=Mus musculus]	418.364	45	73	827	60	1960	226.2	cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;stress response;transport;developmental processes;other biological processes	plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component	signal transduction activity or receptor binding;cytoskeletal activity;other molecular function	17886	ENSMUSG00000022443	Myh9	mmu:17886; Q3UHT9; Q3UHU4; Q6KAN6; Q811I2; Q8VDD5	Primary focal segmental glomerulosclerosis (FSGS)	RHO GTPases activate PAKs; Regulation of actin dynamics for phagocytic cup formation	0.156498497144098	0.0382609387499984	0.118876667035285	0.15125389278925	0.916542675526027	0.91728043005175	0.990873516209569	100319.6147091511	5176534.940650649	8067345.413832072	7844465.70271172	1.9759662960152034E7
Cont_P02453	Collagen alpha-1(I) chain OS=Bos taurus OX=9913 GN=COL1A1 PE=1 SV=3	414.689	43	43	1208	4	1463	138.9	cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes	non-structural extracellular;extracellular matrix;other cell component	extracellular structural activity;other molecular function	282187	ENSBTAG00000013103	COL1A1	bta:282187; P02453; Q3MHM2	Inflammatory response pathway; Osteoblast signaling; Focal adhesion	Fibronectin matrix formation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Collagen degradation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; Collagen chain trimerization; GPVI-mediated activation cascade; Platelet Aggregation (Plug Formation); Platelet Adhesion to exposed collagen; GP1b-IX-V activation signalling	0.800889767710788	0.579410556046386	0.58548007712969	0.839216523231753	0.848119069115724	0.108042253370914	0.0107964100780951	228542.54091026666	3262486.7198886867	3910059.36528234	1102058.9569362423	924822.5329095138
Cont_P02769	Albumin OS=Bos taurus OX=9913 GN=ALB PE=1 SV=4	390.555	81	57	7095	54	607	69.2	stress response;other biological processes	non-structural extracellular;other cell component	nucleic acid binding activity;other molecular function	280717		ALB	A5PJX3; bta:280717; O02787; P02769; P04277; Q3SZR2			0.520832629933248	0.650544967914241	0.598172767155558	0.497906326712893	0.413798631523592	0.846117085258013	0.468531677746422	2.7142766432154403E9	2.9099571807541137E9	2.4034772237737E9	2.38097622607819E9	2.6841204207378564E9
P01027	Complement C3 [OS=Mus musculus]	388.541	53	70	1148	62	1663	186.4	cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes	non-structural extracellular;other cell component	signal transduction activity or receptor binding;enzyme regulator activity	12266	ENSMUSG00000024164	C3	mmu:12266; P01027; Q61370; Q80XP1	Complement activation, classical pathway; Tyrobp causal network in microglia; Comprehensive IL-17A signaling	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade; Neutrophil degranulation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; G alpha (i) signalling events; Peptide ligand-binding receptors; Alternative complement activation; Activation of C3 and C5	0.712660037675161	0.729783028721347	0.506101547380209	0.762068821001752	0.512232143465318	0.413470300505934	0.991722673088443	3269916.660849947	1.6657146132333001E7	4.4549110086954266E7	3.6733221642207734E7	8.026680998659676E7
Cont_Q7SIH1	Alpha-2-macroglobulin OS=Bos taurus OX=9913 GN=A2M PE=1 SV=2	370.864	53	56	1089	56	1510	167.5		non-structural extracellular	enzyme regulator activity;other molecular function	513856	ENSBTAG00000018137	A2M	A8E647; bta:513856; Q7SIH1	IL-6 signaling pathway		0.688450665125024	0.839052280267302	0.731111241255251	0.509007335932165	0.540124873725708	0.671798309985569	0.809503222445875	5.423624331449187E7	7.564994624258716E7	7.018676700369896E7	5.23492843648457E7	8.250822323914327E7
Cont_Q29443	Serotransferrin OS=Bos taurus OX=9913 GN=TF PE=2 SV=1	343.183	74	48	1709	46	704	77.7	stress response;transport;other biological processes	non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle	other molecular function	280705		TF	bta:280705; Q0IIK2; Q29443			0.615274986253429	0.964709887217926	0.600414647182016	0.571407162236119	0.105569810421019	0.506704636011438	0.313748671859839	1.48932090998098E8	2.32106703986673E8	1.5606409762411097E8	1.3567523181654152E8	1.6257112433260167E8
Cont_P07589	Fibronectin OS=Bos taurus OX=9913 GN=FN1 PE=1 SV=4	337.517	26	47	923	11	2478	272	cell adhesion;cell organization and biogenesis;stress response;developmental processes;other biological processes	non-structural extracellular	signal transduction activity or receptor binding;other molecular function			FN1	P07589			0.714071857030863	0.525827426782658	0.94971810013306	0.802863674292211	0.634088329627404	0.35834247597224	0.281927255363179	166255.75410196633	835883.8306505851	952169.9232567847	482619.7682389803	602598.7403397557
Q80X90	Filamin-B [OS=Mus musculus]	335.882	38	75	608	66	2602	277.7	cell organization and biogenesis;stress response;other biological processes	plasma membrane;other membranes;cytosol;cytoskeleton;other cell component	cytoskeletal activity;other molecular function	286940	ENSMUSG00000025278	Flnb	E9QNV9; mmu:286940; Q80X90; Q8VHX4; Q8VHX7; Q99KY3		ISG15 antiviral mechanism	0.296944306247309	0.238365792894698	0.254729742039053	0.629546282386664	0.897564267605108	0.872448101434609	0.866446545996913	154624.23024854946	2351112.5534752235	6048828.490809467	1865154.4144755967	7592568.170254476
Cont_P35527	Keratin, type I cytoskeletal 9 OS=Homo sapiens OX=9606 GN=KRT9 PE=1 SV=3	310.424	69	35	915	34	623	62	cell organization and biogenesis;other biological processes	cytosol;cytoskeleton	cytoskeletal activity	3857	ENSG00000171403	KRT9	hsa:3857; O00109; P35527; Q0IJ47; Q14665		Formation of the cornified envelope	0.836660982916281	0.73072258897653	0.769556732848094	0.964570089320365	0.936669139837906	0.516448827835279	0.0110179641295352	2.9224080803851068E7	3.250630567014273E7	4.1318104811136335E7	9.369998400542612E7	5.1433611479478456E7
Cont_P04264	Keratin, type II cytoskeletal 1 OS=Homo sapiens OX=9606 GN=KRT1 PE=1 SV=6	306.58	65	45	1774	36	644	66	cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes	non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component	bone, tooth or skin structural activity;other molecular function	3848	ENSG00000167768	KRT1	B2RA01; hsa:3848; P04264; P85925; P86104; Q14720; Q6GSJ0; Q9H298	Corticotropin-releasing hormone signaling	Formation of the cornified envelope; Neutrophil degranulation; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	0.65780924735352	0.653826967689551	0.631165145316661	0.89629386854896	0.770634810212039	0.254077056479593	5.78940441291519E-5	1.5397854514739665E8	1.3414412508194733E8	1.6528138436319932E8	4.476405570139613E8	1.7631437693719265E8
P06909	Complement factor H [OS=Mus musculus]	292.01	49	41	540	41	1234	139	cell adhesion;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes	non-structural extracellular;plasma membrane;other membranes;mitochondrion;other cell component	other molecular function	12628	ENSMUSG00000026365	Cfh	mmu:12628; P06909; Q6NZK3		Regulation of Complement cascade	0.205200089226065	0.0359547312524068	1.50457038391225E-17	0.329485122608543	0.532399788858771	0.750662231008662	0.443116920082088	59542.32714759521	1.0566840244224759E7	1.036081717107911E7	8439848.284125684	2.9357524779450033E7
P16546	Spectrin alpha chain, non-erythrocytic 1 [OS=Mus musculus]	291.854	35	74	473	74	2472	284.4	cell organization and biogenesis	plasma membrane;other membranes;cytosol;cytoskeleton;other cell component	cytoskeletal activity;other molecular function	20740	ENSMUSG00000057738	Sptan1	A3KGU6; A3KGU8; P16546; Q8K380; Q9CT05	FAS pathway and stress induction of HSP regulation	Neutrophil degranulation; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Interaction between L1 and Ankyrins; COPI-mediated anterograde transport; RHOU GTPase cycle; RHOV GTPase cycle; Caspase-mediated cleavage of cytoskeletal proteins	0.958962194559628	0.786160319109602	0.611910908670005	0.890289034593217	0.771887919257916	0.870511801558508	0.852906094467594	684626.7741473566	1427277.73205798	3976922.979229001	2263434.85725903	8138355.29233573
Cont_P13645	Keratin, type I cytoskeletal 10 OS=Homo sapiens OX=9606 GN=KRT10 PE=1 SV=6	286.713	62	30	1322	20	584	58.8	cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes	plasma membrane;cytosol;cytoskeleton;other cell component	bone, tooth or skin structural activity;other molecular function	3858	ENSG00000186395	KRT10	hsa:3858; P13645; Q14664; Q8N175		Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	0.600890052902075	0.490821286240141	0.561934876627864	0.941696908693733	0.880940844456856	0.246231694954624	2.55433624902191E-5	1.1091978559495355E8	9.409796786421584E7	1.13950700113199E8	3.19749190691826E8	1.0914077913761683E8
Cont_P35908	Keratin, type II cytoskeletal 2 epidermal OS=Homo sapiens OX=9606 GN=KRT2 PE=1 SV=2	284.975	78	42	1022	32	639	65.4	cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes	plasma membrane;cytosol;cytoskeleton;other cell component	bone, tooth or skin structural activity;cytoskeletal activity	3849	ENSG00000172867	KRT2	hsa:3849; P35908; Q4VAQ2		Formation of the cornified envelope	0.499413631103761	0.411258958244596	0.544106843431104	0.933570718645937	0.862063111456553	0.309041843038519	2.9837536993241E-4	4.776750778997586E7	2.9357809740500167E7	3.415287514761583E7	7.640800383787991E7	3.617272663897294E7
Q62059	Versican core protein [OS=Mus musculus]	279.715	17	44	1073	44	3357	366.6	cell adhesion;developmental processes	non-structural extracellular;extracellular matrix;other cell component	other molecular function			Vcan	Q62058; Q62059; Q9CUU0		ECM proteoglycans; Glycosaminoglycan-protein linkage region biosynthesis; CS/DS degradation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; CS-GAG biosynthesis; DS-GAG biosynthesis	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.613304974369123	0.478009151463064	0.783304059803245	104188.56292801573	9.037034497028168E7	9.467651077277745E7	5.89459061512507E7	9.510262638582683E7
P10493	Nidogen-1 [OS=Mus musculus]	275.191	43	42	852	42	1245	136.5	cell adhesion;cell organization and biogenesis;developmental processes;other biological processes	non-structural extracellular;extracellular matrix;other cell component	other molecular function	18073	ENSMUSG00000005397	Nid1	mmu:18073; P10493; Q3TKX9; Q8BQI3; Q8C3U8; Q8C9P6		Laminin interactions; Degradation of the extracellular matrix	1.65082956259427E-17	1.8644578313253E-17	0.251140212279038	0.461941385639594	0.604382524464811	1.0740690550749E-5	0.781368126060588	322455.2944414853	1.2120394496125467E8	1.2671518083095133E8	9146738.193898173	3.1971627034095198E7
O88207	Collagen alpha-1(V) chain [OS=Mus musculus]	275.025	46	52	413	44	1838	183.6	cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes	extracellular matrix;other cell component	extracellular structural activity;other molecular function	12831	ENSMUSG00000026837	Col5a1	A3KGE3; mmu:12831; O88207; Q3UG94; Q6F6B0	Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion	ECM proteoglycans; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; MET activates PTK2 signaling	1.65082956259427E-17	1.8644578313253E-17	0.268653947705267	0.311207075116757	0.848119069115724	0.302671730722046	0.809503222445875	80388.83753211687	3577832.3612721	8562033.320911517	1386447.3981625708	3098568.0509616495
P37889	Fibulin-2 [OS=Mus musculus]	269.894	43	37	791	37	1221	131.7	other biological processes	non-structural extracellular	other molecular function	14115	ENSMUSG00000064080	Fbln2	G5E8B3; mmu:14115; P37889; Q9WUI2		Molecules associated with elastic fibres	1.65082956259427E-17	0.0640195441309023	0.201227492083465	0.255240026777032	0.803447472095846	0.290132264062119	0.809503222445875	362692.0010392267	6.556805587417743E7	8.021475911820169E7	3.00676966042863E7	4.93487108032657E7
Q8VHX6	Filamin-C [OS=Mus musculus]	249.498	31	65	425	56	2726	290.9	cell organization and biogenesis;other biological processes	plasma membrane;other membranes;cytosol;cytoskeleton;other cell component	cytoskeletal activity	68794	ENSMUSG00000068699	Flnc	B2RY80; B9EKT2; mmu:68794; Q6PAI6; Q8VHX6; Q9JJ38		Cell-extracellular matrix interactions	0.562594032195739	0.719627996749639	0.962331548063155	0.57290809187594	0.96786708205164	0.933437821008547	0.80954066750699	406087.97266412666	1016453.1391661359	2089599.8263247435	1136666.5742976035	4459384.47065665
Q04857	Collagen alpha-1(VI) chain [OS=Mus musculus]	248.981	44	33	588	33	1025	108.4	cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes	non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component	other molecular function	12833	ENSMUSG00000001119	Col6a1	mmu:12833; Q04857		ECM proteoglycans; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Signaling by PDGF; NCAM1 interactions	0.2534363617947	0.392208211277376	0.962331548063155	0.971216996811237	0.97504218639442	0.115965329440656	0.380888676065133	76865.2077476112	5.0068940213435836E7	6.914260176814564E7	1.4473176745930666E7	1.9886194591010433E7
Cont_Q2UVX4	Complement C3 OS=Bos taurus OX=9913 GN=C3 PE=1 SV=2	247.154	39	55	851	47	1661	187.1	cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes	non-structural extracellular;other cell component	signal transduction activity or receptor binding;enzyme regulator activity	280677	ENSBTAG00000017280	C3	bta:280677; Q2KIZ4; Q2UVX4	Complement and coagulation cascades; Complement activation, classical pathway	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Neutrophil degranulation; Peptide ligand-binding receptors; G alpha (i) signalling events; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade; Alternative complement activation; Activation of C3 and C5	0.615680953989958	0.798729234704005	0.573945385766997	0.506364847510615	0.291700662163587	0.591028379533681	0.448532796991499	1.4686759191254234E7	1.84550126489547E7	1.5291804049274266E7	1.196234797265725E7	1.6127794015790733E7
Q62261	Spectrin beta chain, non-erythrocytic 1 [OS=Mus musculus]	244.684	30	61	398	61	2363	274.1	cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes	plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component	cytoskeletal activity;other molecular function	20742	ENSMUSG00000020315	Sptbn1	A2AFU1; mmu:20742; Q3TEM7; Q5SQL8; Q5SQL9; Q62261; Q9QWJ7		COPI-mediated anterograde transport; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; RHOU GTPase cycle; Interaction between L1 and Ankyrins; RHOV GTPase cycle	0.69394578118832	0.776437620310661	0.693719649766064	0.831411077141515	0.86315143463057	0.664971370235365	0.953305976192702	492454.03878621367	920886.7046363313	2921004.358024217	2299979.2063157237	6417771.720584608
Q640N1	Adipocyte enhancer-binding protein 1 [OS=Mus musculus]	239.707	38	34	648	34	1128	128.3	protein metabolism;other biological processes	nucleus;other cell component	nucleic acid binding activity;other molecular function	11568	ENSMUSG00000020473	Aebp1	mmu:11568; O88442; Q3TVV5; Q3TWA7; Q3TX56; Q3TXB2; Q5NCI9; Q61281; Q640N1			0.269326617826563	0.0457359864845759	0.605387748357992	0.631359014803774	0.760992448481534	0.145805028390539	0.963436677882021	4843934.666021533	3.9556778473622136E7	4.1143769603117764E7	1.8648394999714002E7	3.1901344171106894E7
P57780	Alpha-actinin-4 [OS=Mus musculus]	239.42	58	45	483	30	912	104.9	cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes	cytoskeleton;nucleus;other cell component	cytoskeletal activity;other molecular function	60595	ENSMUSG00000054808	Actn4	mmu:60595; P57780	Primary focal segmental glomerulosclerosis (FSGS)	Platelet degranulation	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	0.19149089837131	0.795351011232032	0.968364585136618	0.938282411159324	20900.169415734228	4580996.01302682	9830280.285985528	4440337.50144963	1.1658414413951913E7
Q7TPR4	Alpha-actinin-1 [OS=Mus musculus]	235.529	54	42	511	27	892	103	cell adhesion;cell organization and biogenesis;other biological processes	plasma membrane;other membranes;cytoskeleton;other cell component	signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function	109711	ENSMUSG00000015143	Actn1	mmu:109711; Q7TPR4	Regulation of actin cytoskeleton; Integrin-mediated cell adhesion; Focal adhesion	Platelet degranulation ; RHOF GTPase cycle; RHOBTB2 GTPase cycle; RHOD GTPase cycle; Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	0.995554138371554	0.178726136005694	0.819280225722906	0.941696908693733	0.744084716394381	0.837231569641376	0.879972045955715	486802.1989182571	2525588.7379033365	6210475.170240924	3717490.65968503	9946958.94260729
P02468	Laminin subunit gamma-1 [OS=Mus musculus]	230.882	35	43	454	43	1607	177.2	cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes	non-structural extracellular;extracellular matrix;other cell component	extracellular structural activity;other molecular function			Lamc1	P02468			0.118212047511996	0.116315527815218	0.459134305737471	0.675951294045723	0.877818946381645	0.368062651583427	0.922276466908065	18104.5719498812	7327169.184632126	1.61740059690847E7	3246292.9185144133	7951596.802164167
Q91ZX7	Prolow-density lipoprotein receptor-related protein 1 [OS=Mus musculus]	230.497	15	57	519	56	4545	504.4	other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes	plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component	signal transduction activity or receptor binding;other molecular function	16971		Lrp1	mmu:16971; Q61291; Q91ZX7; Q920Y4	Statin pathway; Wnt signaling pathway	Scavenging of heme from plasma; Retinoid metabolism and transport	1.65082956259427E-17	0.0181625429641231	0.133639440745791	0.150830220548111	0.925871264502428	0.74148782464906	0.901098484497789	30670.78727387535	3548407.5296101067	7355877.025944923	2243610.9879279765	5724840.5342227295
Cont_P60712	Actin, cytoplasmic 1 OS=Bos taurus OX=9913 GN=ACTB PE=1 SV=1	225.45	70	19	852	2	375	41.7	cell organization and biogenesis;stress response;developmental processes;other biological processes	plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component	enzyme regulator activity;cytoskeletal activity;other molecular function	100033878; 100135470; 100173832; 101844587; 102139853; 11461; 118833809; 280979; 396526; 403580; 414396; 443052; 450133; 60; 81822	ENSBTAG00000026199; ENSCAFG00000016020; ENSCAFG00030015381; ENSCAFG00040015695; ENSCPOG00000013467; ENSG00000075624; ENSMAUG00000008763; ENSMUSG00000029580; ENSOARG00040012985; ENSOARG00180022443; ENSOARG00185023855; ENSOARG00215030140; ENSOARG00225009314; ENSPPYG00000017336; ENSPTRG00000018890; ENSRNOG00000034254; ENSSSCG00000007585; ENSSSCG00030003451; ENSSSCG00035038792; ENSSSCG00040049462; ENSSSCG00045027458; ENSSSCG00050065025; ENSSSCG00055012597; ENSSSCG00060019124; ENSSSCG00065037921; ENSSSCG00070011353; ENSSSCG00105030144; ENSSSCG00110026965; ENSSSCG00115013637; ENSSSCG00130033784	Actb; ACTB	A5D961; A5PKA1; bta:280979; cfa:403580; cpoc:100135470; csab:103246953; ecb:100033878; gga:396526; hsa:60; maua:101844587; mmu:11461; O18840; oas:443052; P02570; P60706; P60707; P60708; P60709; P60710; P60711; P60712; P60713; P70514; P99021; pon:100173832; ptr:450133; Q11209; Q11211; Q3SZD2; Q3TI89; Q3TVP6; Q4L0Y2; Q4R561; Q5R1X3; Q5R582; Q5R6G0; Q64316; Q6QAQ1; Q6ZWM3; Q711N9; Q71FK5; Q75MN2; Q76N69; Q8MIJ0; Q8SPX4; Q95164; Q96B34; Q96HG5; rno:81822; ssc:414396	FAS pathway and stress induction of HSP regulation; Actin cytoskeleton regulation; Myometrial relaxation and contraction pathways; Focal adhesion; Arrhythmogenic right ventricular cardiomyopathy; Pathogenic Escherichia coli infection; Common pathways underlying drug addiction; Myometrial relaxation and contraction pathways; Focal adhesion; Fas ligand pathway and stress induction of heat shock proteins; Pathogenic Escherichia coli infection; Arrhythmogenic right ventricular cardiomyopathy; Focal adhesion; Myometrial relaxation and contraction pathways; Regulation of actin cytoskeleton; Myometrial relaxation and contraction pathways; Ebola virus infection in host; Acute viral myocarditis; Thermogenesis; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Overlap between signal transduction pathways contributing to LMNA laminopathies; Pleural mesothelioma; Regulation of actin cytoskeleton; Network map of SARS-CoV-2 signaling; Regulation of actin cytoskeleton; Regulation of actin cytoskeleton; Focal adhesion	Formation of the canonical BAF (cBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); Regulation of actin dynamics for phagocytic cup formation; EPH-ephrin mediated repulsion of cells; Formation of annular gap junctions; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; RHO GTPases Activate Formins; RHOF GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; B-WICH complex positively regulates rRNA expression; Regulation of CDH1 Function; Formation of the dystrophin-glycoprotein complex (DGC); Formation of the canonical BAF (cBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); RHO GTPases Activate WASPs and WAVEs; UCH proteinases; DNA Damage Recognition in GG-NER; Formation of the non-canonical BAF (ncBAF) complex; RHO GTPases activate IQGAPs; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Cell-extracellular matrix interactions; MAP2K and MAPK activation; Interaction between L1 and Ankyrins; RHOF GTPase cycle; DNA Damage Recognition in GG-NER; MAP2K and MAPK activation; RHO GTPases Activate Formins; Clathrin-mediated endocytosis; UCH proteinases; RHOF GTPase cycle; DNA Damage Recognition in GG-NER; EPH-ephrin mediated repulsion of cells; VEGFA-VEGFR2 Pathway; Regulation of actin dynamics for phagocytic cup formation; Adherens junctions interactions; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); RHO GTPases Activate WASPs and WAVEs; B-WICH complex positively regulates rRNA expression; Regulation of CDH1 Function; EPHB-mediated forward signaling; Formation of the non-canonical BAF (ncBAF) complex; Formation of the canonical BAF (cBAF) complex; Formation of annular gap junctions; RHO GTPases activate IQGAPs; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; RHO GTPases Activate WASPs and WAVEs; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RHO GTPases activate IQGAPs; RHO GTPases Activate Formins; RHOF GTPase cycle; Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs); B-WICH complex positively regulates rRNA expression; Signaling by BRAF and RAF1 fusions; UCH proteinases; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; VEGFA-VEGFR2 Pathway; Formation of the dystrophin-glycoprotein complex (DGC); Factors involved in megakaryocyte development and platelet production; Regulation of MITF-M-dependent genes involved in pigmentation; Formation of the canonical BAF (cBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); EPH-ephrin mediated repulsion of cells; HATs acetylate histones; Interaction between L1 and Ankyrins; Prefoldin mediated transfer of substrate to CCT/TriC; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Adherens junctions interactions; Regulation of CDH1 Function; Formation of the non-canonical BAF (ncBAF) complex; DNA Damage Recognition in GG-NER; Formation of the polybromo-BAF (pBAF) complex; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Formation of annular gap junctions; Folding of actin by CCT/TriC; Cell-extracellular matrix interactions; MAP2K and MAPK activation; RHO GTPases Activate Formins; Recycling pathway of L1; RHO GTPases activate IQGAPs; Clathrin-mediated endocytosis; Formation of the dystrophin-glycoprotein complex (DGC); EPHB-mediated forward signaling; UCH proteinases; B-WICH complex positively regulates rRNA expression; Adherens junctions interactions; Formation of the non-canonical BAF (ncBAF) complex; Formation of annular gap junctions; Formation of the polybromo-BAF (pBAF) complex; VEGFA-VEGFR2 Pathway; Cell-extracellular matrix interactions; RHO GTPases Activate WASPs and WAVEs; Regulation of CDH1 Function; Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; UCH proteinases; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); Formation of the polybromo-BAF (pBAF) complex; B-WICH complex positively regulates rRNA expression; DNA Damage Recognition in GG-NER; Formation of the canonical BAF (cBAF) complex; RHO GTPases Activate Formins; Regulation of CDH1 Function; Interaction between L1 and Ankyrins; RHOF GTPase cycle; Formation of the non-canonical BAF (ncBAF) complex; Adherens junctions interactions; Formation of the dystrophin-glycoprotein complex (DGC); VEGFA-VEGFR2 Pathway; RHO GTPases Activate WASPs and WAVEs; Cell-extracellular matrix interactions; EPHB-mediated forward signaling; MAP2K and MAPK activation; Recycling pathway of L1; RHO GTPases activate IQGAPs; Formation of annular gap junctions; B-WICH complex positively regulates rRNA expression; UCH proteinases; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); MAP2K and MAPK activation; Formation of the polybromo-BAF (pBAF) complex; RHO GTPases Activate Formins; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases Activate WASPs and WAVEs; Formation of the dystrophin-glycoprotein complex (DGC); VEGFA-VEGFR2 Pathway; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; DNA Damage Recognition in GG-NER; RHOF GTPase cycle; Cell-extracellular matrix interactions; Adherens junctions interactions; Formation of the non-canonical BAF (ncBAF) complex; Formation of the canonical BAF (cBAF) complex; RHO GTPases activate IQGAPs; Regulation of CDH1 Function; Gap junction degradation; Formation of annular gap junctions; Regulation of actin dynamics for phagocytic cup formation; RHOF GTPase cycle; Clathrin-mediated endocytosis; RHO GTPases Activate Formins; Cell-extracellular matrix interactions; VEGFA-VEGFR2 Pathway; Adherens junctions interactions; RHO GTPases activate IQGAPs; UCH proteinases; EPHB-mediated forward signaling; MAP2K and MAPK activation; RHO GTPases Activate WASPs and WAVEs; Formation of the dystrophin-glycoprotein complex (DGC); Formation of annular gap junctions; Formation of the canonical BAF (cBAF) complex; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of the non-canonical BAF (ncBAF) complex; Regulation of CDH1 Function	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.994348552930242	0.963278515868644	0.938282411159324	1996659.4544256767	4.828873920581084E7	6.5074451419171505E7	5.335770948168167E7	1.0984219759318356E8
P63260	Actin, cytoplasmic 2 [OS=Mus musculus]	217.791	70	19	831	2	375	41.8	cell organization and biogenesis;stress response;developmental processes;other biological processes	non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component	cytoskeletal activity;other molecular function	11465	ENSMUSG00000062825	Actg1	mmu:11465; P02571; P14104; P63260; P99022	Myometrial relaxation and contraction pathways; Regulation of actin cytoskeleton; Focal adhesion	Platelet degranulation ; RHO GTPases activate IQGAPs; Adherens junctions interactions; Regulation of CDH1 Function; RHO GTPases Activate Formins; Regulation of actin dynamics for phagocytic cup formation; Interaction between L1 and Ankyrins; MAP2K and MAPK activation; Recycling pathway of L1; Clathrin-mediated endocytosis; Formation of the dystrophin-glycoprotein complex (DGC); EPHB-mediated forward signaling; RHOF GTPase cycle; Formation of annular gap junctions; VEGFA-VEGFR2 Pathway; Cell-extracellular matrix interactions; RHO GTPases Activate WASPs and WAVEs; RHOBTB2 GTPase cycle	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.901789796153066	0.731487178650893	0.819844267712751		145698.54484736864	254666.434448248	126248.83655432604	256671.2110968777
P33434	72 kDa type IV collagenase [OS=Mus musculus]	212.03	56	30	889	30	662	74.1	cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes	extracellular matrix;plasma membrane;other membranes;cytoskeleton;mitochondrion;nucleus;other cell component	other molecular function	17390	ENSMUSG00000031740	Mmp2	mmu:17390; P33434	Lung fibrosis; IL-3 signaling pathway; Matrix metalloproteinases	Collagen degradation; Extra-nuclear estrogen signaling; EPH-ephrin mediated repulsion of cells; Activation of Matrix Metalloproteinases	0.372996577396536	0.964209443670126	0.342075680986172	0.708142491896103	0.459747209584207	0.34519376377552	0.809503222445875	2.5908623508144036E7	2.11513119484971E7	6.116415043649567E7	5.359802560613743E7	8.73371018908004E7
P19096	Fatty acid synthase [OS=Mus musculus]	203.372	23	48	335	48	2504	272.3	other metabolic processes;stress response;other biological processes	plasma membrane;other membranes;cytosol;ER/Golgi;other cell component	other molecular function	14104	ENSMUSG00000025153	Fasn	B1ATU8; mmu:14104; P19096; Q6PB72; Q8C4Z0; Q9EQR0	Fatty acid biosynthesis; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-9 fatty acid synthesis; Elongation of (very) long chain fatty acids	Fatty acyl-CoA biosynthesis; Vitamin B5 (pantothenate) metabolism	0.66189768147619	0.847457711018997	0.951921622352553	0.605074788683686	0.994834213681465	0.746782404466558	0.990873516209569	102793.32580216101	1389784.0897720233	2729524.669883373	892753.3234074336	2995475.6339221266
Cont_Q3SZ57	Alpha-fetoprotein OS=Bos taurus OX=9913 GN=AFP PE=2 SV=1	202.89	62	30	1153	29	610	68.5	other metabolic processes;developmental processes;other biological processes	non-structural extracellular;other cell component	other molecular function	506011	ENSBTAG00000017131	AFP	bta:506011; Q3SZ57		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation	0.540832988168188	0.82964085881652	0.605387748357992	0.553772240900005	0.15729598575093	0.699570390946254	0.323545662226049	3.8603879197485335E7	4.5317948160280704E7	3.6151020512819335E7	3.679174310656657E7	4.2915740009991035E7
P48678	Prelamin-A/C [OS=Mus musculus]	202.607	60	37	529	36	665	74.2	cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes	other membranes;cytoskeleton;nucleus;other cell component	other molecular function	16905	ENSMUSG00000028063	Lmna	B3RH23; B3RH24; mmu:16905; P11516; P48678; P97859; Q3TIH0; Q3TTS8; Q3U733; Q3U7I5; Q3UCA0; Q3UCJ8; Q3UCU3; Q91WF2; Q9DC21	Adipogenesis genes; FAS pathway and stress induction of HSP regulation		1.65082956259427E-17	0.00670345592293191	0.139423967594304	1.70336894001643E-17	0.77212820363828	0.901149690306505	0.00692305873191716	75722.11050192213	4134986.871037207	1.1058985470826533E7	6289356.16248022	5.369543399964929E7
Q02788	Collagen alpha-2(VI) chain [OS=Mus musculus]	202.37	41	36	585	36	1034	110.3	cell adhesion;signal transduction;other biological processes	non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component	other molecular function	12834	ENSMUSG00000020241	Col6a2	mmu:12834; Q02788; Q05505; Q8C972; Q8K229	Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion	ECM proteoglycans; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation	0.175734701097799	1.8644578313253E-17	0.633123216104285	0.767312384697355	0.880899056945259	0.0961283818482991	0.809503222445875	121237.29953889274	4.136492509189963E7	5.21291258166705E7	1.173163988850227E7	2.0595787144729633E7
P97927	Laminin subunit alpha-4 [OS=Mus musculus]	199.33	30	41	409	41	1816	201.7	cell adhesion;developmental processes;other biological processes	non-structural extracellular;extracellular matrix;other cell component	signal transduction activity or receptor binding	16775	ENSMUSG00000019846	Lama4	mmu:16775; O88785; P70409; P97927; Q14BF2	Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion	Formation of the dystrophin-glycoprotein complex (DGC); Laminin interactions; MET activates PTK2 signaling	0.496649188935323	0.645007535999596	0.952104483873957	0.825047045401531	0.929291541980042	0.50594120050135	0.819844267712751	390078.69973194966	5125646.74812024	1.037511250312096E7	3065544.409694903	5760601.1965567535
P20152	Vimentin [OS=Mus musculus]	183.446	60	29	762	27	466	53.7	cell organization and biogenesis;stress response;developmental processes;other biological processes	plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component	cytoskeletal activity;nucleic acid binding activity;other molecular function	22352	ENSMUSG00000026728	Vim	mmu:22352; O08704; P20152; Q8CCH1	Spinal cord injury; Primary focal segmental glomerulosclerosis (FSGS); Alpha 6 beta 4 integrin signaling pathway	Aggrephagy; Striated Muscle Contraction; Caspase-mediated cleavage of cytoskeletal proteins; RHOBTB1 GTPase cycle	1.65082956259427E-17	0.0955146622024883	1.50457038391225E-17	0.137621774180062	0.0297998664849654	0.840672080806375	0.0332723373064956	1112472.104030337	7365249.698992513	3.3401280645601466E7	1.292797841903164E7	7.464184195594883E7
Q64727	Vinculin [OS=Mus musculus]	182.753	50	45	419	45	1066	116.6	cell adhesion;cell organization and biogenesis;developmental processes;other biological processes	plasma membrane;other membranes;cytoskeleton;other cell component	cytoskeletal activity;other molecular function	22330	ENSMUSG00000021823	Vcl	mmu:22330; Q64727; Q8BP32; Q8BS46; Q922C5; Q922D9	Primary focal segmental glomerulosclerosis (FSGS); IL-3 signaling pathway; Regulation of actin cytoskeleton; Integrin-mediated cell adhesion; Focal adhesion	Neutrophil degranulation; High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells; Platelet degranulation ; MAP2K and MAPK activation; Smooth Muscle Contraction; Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells; Regulation of CDH1 Function	0.208404050858596	0.190838415616571	0.238791978742132	0.504745711776551	0.878264980963866	0.977491813528386	0.958518237573655	126150.06188907423	1953982.7579073233	4840837.086136207	2359150.5810886133	6758257.200309387
Q8K4G1	Latent-transforming growth factor beta-binding protein 4 [OS=Mus musculus]	180.216	27	29	318	29	1666	178.5	cell-cell signaling;cell organization and biogenesis;transport;signal transduction	non-structural extracellular;extracellular matrix	other molecular function	108075	ENSMUSG00000040488	Ltbp4	E9QPD9; mmu:108075; Q8K4G0; Q8K4G1		TGF-beta receptor signaling activates SMADs; Molecules associated with elastic fibres	0.308350896322176	0.362779483059131	1.50457038391225E-17	0.170566190602959	0.958956615096849	0.703189639676216	0.915193515309545	50068.58855747415	1469976.6770863	2473680.681365607	2657641.7444799202	7291299.088613093
Q68FD5	Clathrin heavy chain 1 [OS=Mus musculus]	180.117	32	43	363	43	1675	191.4	cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes	plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component	nucleic acid binding activity;other molecular function	67300	ENSMUSG00000047126	Cltc	mmu:67300; Q68FD5	IL-7 signaling pathway; Kit receptor signaling pathway	MHC class II antigen presentation; Recycling pathway of L1; Cargo recognition for clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis; LDL clearance; Retrograde neurotrophin signalling; Formation of annular gap junctions; Lysosome Vesicle Biogenesis; WNT5A-dependent internalization of FZD4; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation; RHOU GTPase cycle; RHOV GTPase cycle	0.4248536990637	0.198232028950426	1.50457038391225E-17	0.413413145615294	0.840666598828607	0.946476383814868	0.835383236382767	14581.209031729499	1426606.2225329466	2101059.0869428	2078296.563295177	6830362.818457293
P02469	Laminin subunit beta-1 [OS=Mus musculus]	179.863	27	40	429	39	1786	197	cell adhesion;cell organization and biogenesis;developmental processes;other biological processes	non-structural extracellular;extracellular matrix;nucleus;other cell component	signal transduction activity or receptor binding;extracellular structural activity;other molecular function	16777	ENSMUSG00000002900	Lamb1	E9PXZ9; P02469	Focal adhesion: PI3K-Akt-mTOR signaling pathway; Inflammatory response pathway; Alpha 6 beta 4 integrin signaling pathway; Focal adhesion		0.205801242418232	0.341417478664423	0.526489846375643	0.891178501081124	0.900334730044572	0.356773085915651	0.98779298590131	1.0460538665187027E7	1.4326337702720901E7	1.8407714250900764E7	2.1078383512013834E7	1.149610392953332E7
Q01853	Transitional endoplasmic reticulum ATPase [OS=Mus musculus]	179.055	52	32	411	32	806	89.3	cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;other biological processes	other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component	signal transduction activity or receptor binding;enzyme regulator activity;other molecular function	269523	ENSMUSG00000028452	Vcp	mmu:269523; Q01853; Q3TFH9; Q3TIM2; Q3TXN9; Q6PI18; Q8BSR6; Q8CEG4	IL-9 signaling pathway	RHOH GTPase cycle; Neutrophil degranulation; Protein methylation; Ovarian tumor domain proteases; Neddylation; ABC-family proteins mediated transport; Translesion Synthesis by POLH; Hedgehog ligand biogenesis; KEAP1-NFE2L2 pathway; HSF1 activation; N-glycan trimming in the ER and Calnexin/Calreticulin cycle; Josephin domain DUBs	0.915230778358139	0.645007535999596	0.808626104853287	0.953867932777128	0.877818946381645	0.901149690306505	0.737824045087029	621808.5300221853	5338414.413398174	9329554.935730066	4463650.11042755	1.2770955118061693E7
Q03350	Thrombospondin-2 [OS=Mus musculus]	178.303	35	30	328	29	1172	129.8	cell adhesion;other biological processes	non-structural extracellular;extracellular matrix;other cell component	other molecular function	21826	ENSMUSG00000023885	Thbs2	mmu:21826; Q03350; Q8CG21	Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion	Signaling by PDGF; O-glycosylation of TSR domain-containing proteins	0.425958502904743	0.861805134687803	0.49027994509233	0.535702081245677	0.900334730044572	0.620448351319483	0.80954066750699	1929828.2171104867	7439397.130180354	1.1102887711296873E7	4211942.301314384	1.05864549049655E7
Q80YX1	Tenascin [OS=Mus musculus]	175.9	28	43	191	43	2110	231.7	cell adhesion;cell-cell signaling;cell organization and biogenesis;stress response;developmental processes;other biological processes	non-structural extracellular;extracellular matrix;other cell component	signal transduction activity or receptor binding;other molecular function	21923	ENSMUSG00000028364	Tnc	mmu:21923; Q64706; Q80YX1; Q80YX2	Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion	Integrin cell surface interactions; ECM proteoglycans; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation	0.117980756369098	0.827773046590747	0.560799429150649	0.474732236495646	0.00280630917527262	0.00972980877962454	0.46732263590517	20862.416559578665	1449614.4281484466	1.2106484504902953E7	96243.5238250637	211010.04547923067
Q61147	Ceruloplasmin [OS=Mus musculus]	175.43	36	33	380	33	1061	121.1	cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes	non-structural extracellular	other molecular function	12870	ENSMUSG00000003617	Cp	mmu:12870; Q61147; Q6P5C8		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Iron uptake and transport; Metal ion SLC transporters	1.65082956259427E-17	0.0286042496128814	0.232756100865398	0.470567140616547	0.902824569867946	0.217345018530886	0.830251457557488	116072.0240394514	4703216.257241024	9598922.193485493	1756646.5467629798	3587720.1567995367
Q3UQ28	Peroxidasin homolog [OS=Mus musculus]	173.636	35	39	366	39	1475	165	cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes	extracellular matrix;ER/Golgi;other cell component	extracellular structural activity;other molecular function	69675	ENSMUSG00000020674	Pxdn	A4FU83; E9QNQ9; mmu:69675; Q3UQ28		Crosslinking of collagen fibrils	0.121749369203589	0.199060935853007	0.481687712882875	0.64860195920101	0.680311384167738	0.622521206052951	0.910753558746772	52188.79804577449	3468268.863888983	1.0141728842991263E7	1748064.7562207088	5865453.59009746
Q61316	Heat shock 70 kDa protein 4 [OS=Mus musculus]	169.044	48	31	300	31	841	94.1	protein metabolism;other metabolic processes	other cell component	other molecular function			Hspa4	Q61316		Regulation of HSF1-mediated heat shock response	0.675982462193546	0.947627746595709	0.704651587991194	0.760498481134506	0.922660568001848	0.905946265571965	0.842404289073844	51496.56273693644	1715523.4149199834	3885769.0116153997	1450318.0074060035	4790126.20554149
Cont_P02533	Keratin, type I cytoskeletal 14 OS=Homo sapiens OX=9606 GN=KRT14 PE=1 SV=4	164.831	58	26	684	9	472	51.5	cell organization and biogenesis;other biological processes	plasma membrane;cytosol;cytoskeleton;nucleus;other cell component	cytoskeletal activity;other molecular function	3861	ENSG00000186847	KRT14	hsa:3861; P02533; Q14715; Q53XY3; Q9BUE3; Q9UBN2; Q9UBN3; Q9UCY4	Corticotropin-releasing hormone signaling	Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin; Developmental Lineage of Mammary Gland Myoepithelial Cells; Type I hemidesmosome assembly	0.821333803243143	0.880930298968675	0.666244110962191	0.887279041944908	0.728871118050286	0.645534074006669	1.76226512549596E-4	6829492.454091667	1.0299655985485494E7	9892865.41378706	2.9333304518974166E7	9460012.597296894
P11499	Heat shock protein HSP 90-beta [OS=Mus musculus]	164.719	50	29	532	19	724	83.2	cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes	non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component	enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function	15516	ENSMUSG00000023944	Hsp90ab1	mmu:15516; O89078; P11499; Q3UIQ7	Focal adhesion: PI3K-Akt-mTOR signaling pathway	Neutrophil degranulation; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of actin dynamics for phagocytic cup formation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Attenuation phase; Estrogen-dependent gene expression; Sema3A PAK dependent Axon repulsion; Aryl hydrocarbon receptor signalling; DDX58/IFIH1-mediated induction of interferon-alpha/beta; HSF1 activation; RHOBTB2 GTPase cycle; The NLRP3 inflammasome	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.385192173946943	0.975071223710592	0.476079393565723	166033.98771248801	1.0807613687705928E7	3.193268303009924E7	1.1608041082716169E7	4.22825068683512E7
Q9JKF1	Ras GTPase-activating-like protein IQGAP1 [OS=Mus musculus]	163.926	28	36	250	36	1657	188.6	cell organization and biogenesis;developmental processes;signal transduction;other biological processes	plasma membrane;other membranes;cytoskeleton;nucleus;other cell component	enzyme regulator activity;other molecular function	29875	ENSMUSG00000030536	Iqgap1	G3UW45; mmu:29875; Q9JKF1	G13 signaling pathway; Regulation of actin cytoskeleton	RHO GTPases activate IQGAPs; Neutrophil degranulation; RAC1 GTPase cycle; RAC2 GTPase cycle; RHOA GTPase cycle; MAP2K and MAPK activation; RHOQ GTPase cycle; RHOC GTPase cycle; RHOU GTPase cycle; RHOV GTPase cycle; Nephrin family interactions	0.930229675308081	0.794460986683881	0.787568130909409	0.991639536226218	0.941920360687835	0.777195460870953	0.924682711624237	58984.367745696	331165.4406654323	1068898.0084058929	944145.2185002686	3795509.9873349466
P52480	Pyruvate kinase PKM [OS=Mus musculus]	163.393	62	27	442	27	531	57.8	cell organization and biogenesis;other metabolic processes;other biological processes	cytosol;ER/Golgi;nucleus;other cell component	nucleic acid binding activity;kinase activity;other molecular function	18746	ENSMUSG00000032294	Pkm	mmu:18746; P52480; Q3TBV8; Q3TBW5; Q3TC59; Q3U1X3; Q3U5P6; Q4VC20; Q64484; Q91YI8; Q9CWB1	Glycolysis and gluconeogenesis; Purine metabolism	Neutrophil degranulation; Pyruvate metabolism; Glycolysis; Regulation of pyruvate metabolism	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.972868731003358	0.958705855138011	0.959522188921769	224031.9482756436	1.1706302394897154E7	1.6687028973496003E7	1.3595916090065738E7	3.1698865102110166E7
P63017	Heat shock cognate 71 kDa protein [OS=Mus musculus]	161.557	53	28	572	23	646	70.8	cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;other biological processes	non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component	signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function	15481	ENSMUSG00000015656	Hspa8	mmu:15481; P08109; P12225; P63017; Q3U6R0; Q3U764; Q3U7D7; Q3U7E2; Q3U9B4; Q3U9G0; Q3UGM0; Q5FWJ6; Q62373; Q62374; Q62375; Q6NZD0	Mapk signaling pathway; Exercise-induced circadian regulation	Neutrophil degranulation; mRNA Splicing - Major Pathway; Regulation of HSF1-mediated heat shock response; PKR-mediated signaling; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis; Attenuation phase; Lysosome Vesicle Biogenesis; GABA synthesis, release, reuptake and degradation; AUF1 (hnRNP D0) binds and destabilizes mRNA; Protein methylation	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.953011140807089	0.709593139419252	0.587315224195015	232221.67704249235	1.5723480869725833E7	2.2348098618015703E7	1.2001189016638666E7	3.440867978172333E7
Q9JHU4	Cytoplasmic dynein 1 heavy chain 1 [OS=Mus musculus]	161.009	14	55	258	55	4644	531.7	cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes	cytoskeleton;other cell component	cytoskeletal activity;other molecular function	13424	ENSMUSG00000018707	Dync1h1	E9QM71; mmu:13424; Q9JHU4		MHC class II antigen presentation; Neutrophil degranulation; Separation of Sister Chromatids; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; COPI-mediated anterograde transport; Recruitment of NuMA to mitotic centrosomes; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-independent Golgi-to-ER retrograde traffic; Aggrephagy; Anchoring of the basal body to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; AURKA Activation by TPX2	0.591873375996003	0.826895204418257	0.758743075163871	0.936818656936794	0.987352798667733	0.695927216301667	0.953305976192702	294620.0253220563	451351.8596347517	1275535.4534856554	1462326.6297541	5162177.518126
Q99K41	EMILIN-1 [OS=Mus musculus]	157.011	31	21	244	21	1017	107.5	cell adhesion;cell organization and biogenesis;developmental processes;other biological processes	non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component	signal transduction activity or receptor binding;extracellular structural activity;other molecular function	100952	ENSMUSG00000029163	Emilin1	mmu:100952; Q99K41		Molecules associated with elastic fibres	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.64186124184599	0.0921665663508908	0.491906845171331		1671715.86234765	5498413.09956387	384416.66366236034	2364922.89508055
Q61879	Myosin-10 [OS=Mus musculus]	146	19	31	236	20	1976	228.9	cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes	plasma membrane;other membranes;cytosol;cytoskeleton;other cell component	cytoskeletal activity;nucleic acid binding activity;other molecular function	77579	ENSMUSG00000020900	Myh10	mmu:77579; Q5SV63; Q61879	Regulation of actin cytoskeleton	RHO GTPases activate PAKs	0.705689538076567	0.506231596289679	0.676239752697828	0.933545599871938	0.990096171400123	0.953146340313072	0.921444667457376	123378.89612673952	266023.60455562966	458865.269073755	562909.3462758837	1089526.38375758
Cont_P00761	Trypsin OS=Sus scrofa OX=9823 PE=1 SV=1	143.502	62	11	3859	10	231	24.4	protein metabolism;other biological processes	non-structural extracellular	other molecular function							0.254996071775817	0.172153475402034	0.357784551188889	0.34040294575649	0.740968241512781	0.960577895552113	0.148582186670595	5.863252009900073E9	3.334729419178533E9	2.1792138371661735E9	4.479417756781787E9	2.35988129070601E9
P20029	Endoplasmic reticulum chaperone BiP [OS=Mus musculus]	142.966	48	25	434	23	655	72.4	protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes	non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component	enzyme regulator activity;translation activity;other molecular function	14828	ENSMUSG00000026864	Hspa5	mmu:14828; O35642; P20029; Q3UFF2; Q61630	Mapk signaling pathway	Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Regulation of HSF1-mediated heat shock response	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.769590657123576	0.985707795620743	0.888702680095366		7392689.481756757	8222965.927916382	8403011.594768586	1.57890948929286E7
Cont_P13647	Keratin, type II cytoskeletal 5 OS=Homo sapiens OX=9606 GN=KRT5 PE=1 SV=3	142.395	51	34	500	20	590	62.3	cell organization and biogenesis;other biological processes	cytosol;cytoskeleton;other cell component	bone, tooth or skin structural activity;cytoskeletal activity;other molecular function	3852	ENSG00000186081	KRT5	hsa:3852; P13647; Q6PI71; Q6UBJ0; Q8TA91		Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin; Developmental Lineage of Mammary Stem Cells; Developmental Lineage of Mammary Gland Myoepithelial Cells; Type I hemidesmosome assembly	0.786915923361782	0.847457711018997	0.707170943024881	0.746833150482801	0.714156118974909	0.2733017775894	2.49132633766938E-5	5615099.536380176	7868513.182470503	9974982.226041706	2.8752414910160065E7	1.3998817771053001E7
Cont_P08779	Keratin, type I cytoskeletal 16 OS=Homo sapiens OX=9606 GN=KRT16 PE=1 SV=4	140.751	54	25	569	12	473	51.2	cell organization and biogenesis;stress response;other biological processes	plasma membrane;cytosol;cytoskeleton	cytoskeletal activity	3868	ENSG00000186832	KRT16	A8K488; hsa:3868; P08779; P30654; Q16402; Q9UBG8	Vitamin D receptor pathway	Formation of the cornified envelope	0.941324060398065	0.961351301268194	0.761460393544015	0.887279041944908	0.493923182294169	0.895302208460818	3.1065941501805E-4	1275668.1444026066	3908256.3409277797	2249474.51763106	5401589.786976026	2569640.8216647534
Cont_P02465	Collagen alpha-2(I) chain OS=Bos taurus OX=9913 GN=COL1A2 PE=1 SV=2	139.99	18	19	445	3	1364	129		non-structural extracellular;extracellular matrix	extracellular structural activity;other molecular function	282188	ENSBTAG00000013472	COL1A2	A6QP13; bta:282188; O62649; P02465	Inflammatory response pathway; Focal adhesion	Fibronectin matrix formation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Collagen degradation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; Collagen chain trimerization; GPVI-mediated activation cascade; Platelet Aggregation (Plug Formation); Platelet Adhesion to exposed collagen; GP1b-IX-V activation signalling	0.483779141493222	0.876027096029978	0.421836754550416	0.488872343346086	0.076245756040016	0.549852418071669	0.432748651973214	70110.45197339094	85775.39066064726	163731.944383145	48702.045776696206	54970.44581499727
Cont_P12763	Alpha-2-HS-glycoprotein OS=Bos taurus OX=9913 GN=AHSG PE=1 SV=2	132.772	50	16	1191	16	359	38.4	stress response;other biological processes	non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component	enzyme regulator activity	280988		AHSG	A6QLF7; bta:280988; P12763		Neutrophil degranulation; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation	0.573667790345329	0.793013134473823	0.624272910267193	0.36488675645736	0.268930374946741	0.335956814949331	0.913214993335179	6.882384659684638E8	8.712402787486216E8	6.41500953397899E8	4.440672611032756E8	7.064361313920757E8
P07901	Heat shock protein HSP 90-alpha [OS=Mus musculus]	132.382	43	25	402	16	733	84.7	cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes	plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component	signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function	15519	ENSMUSG00000021270	Hsp90aa1	mmu:15519; P07901	EBV LMP1 signaling; Focal adhesion: PI3K-Akt-mTOR signaling pathway; IL-6 signaling pathway; IL-2 signaling pathway	Regulation of necroptotic cell death; Recruitment of NuMA to mitotic centrosomes; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of actin dynamics for phagocytic cup formation; Neutrophil degranulation; Downregulation of ERBB2 signaling; Anchoring of the basal body to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; AURKA Activation by TPX2; Extra-nuclear estrogen signaling; Attenuation phase; Estrogen-dependent gene expression; Sema3A PAK dependent Axon repulsion; VEGFR2 mediated vascular permeability; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation; DDX58/IFIH1-mediated induction of interferon-alpha/beta; eNOS activation; HSF1 activation; RHOBTB2 GTPase cycle; Drug-mediated inhibition of ERBB2 signaling	1.65082956259427E-17	0.508730894200713	1.50457038391225E-17	0.251664970734015	0.788764875934969	0.968364585136618	0.745600589176001	138049.65358917884	1667357.9717776468	3968795.71909318	1606774.576019598	6014683.841021903
Q02819	Nucleobindin-1 [OS=Mus musculus]	131.152	51	21	299	21	459	53.4	signal transduction	non-structural extracellular;other membranes;ER/Golgi	enzyme regulator activity;nucleic acid binding activity;other molecular function	18220	ENSMUSG00000030824	Nucb1	mmu:18220; Q02819; Q3TU42; Q9CWA1; Q9D8J4; Q9DBL3		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	0.130903496983571	0.340647566778883	0.397987186613988	0.958122559708965	30635.69892492515	5493436.34719679	1.9240052036173E7	2379424.5332984333	6548209.148806977
Q91V92	ATP-citrate synthase [OS=Mus musculus]	129.973	32	28	237	28	1091	119.7	other metabolic processes	cytosol	other molecular function	104112	ENSMUSG00000020917	Acly	mmu:104112; Q91V92	Fatty acid biosynthesis	Neutrophil degranulation; Fatty acyl-CoA biosynthesis	0.230775890814232	0.371468864113786	0.437429424171984	0.509570119936397	0.98558531112136	0.643183834410259	0.922580167429744	27537.414327710998	1276919.6113413726	2339759.4103227933	644183.8162072281	1777761.9344937534
A2ASQ1	Agrin [OS=Mus musculus]	128.989	18	26	227	26	1950	207.4	cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes	non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cell component	signal transduction activity or receptor binding;other molecular function	11603	ENSMUSG00000041936	Agrn	A2ASP9; A2ASQ0; A2ASQ1; B2RWU1	Primary focal segmental glomerulosclerosis (FSGS)	ECM proteoglycans; Retinoid metabolism and transport; Glycosaminoglycan-protein linkage region biosynthesis; HS-GAG biosynthesis; HS-GAG degradation; Formation of the dystrophin-glycoprotein complex (DGC)	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.972791368602389	0.686318824668434	0.846971399004193		1695001.2322350666	3018900.06344302	1028829.4241236168	2045725.4701757336
Q61508	Extracellular matrix protein 1 [OS=Mus musculus]	127.379	45	18	358	18	559	62.8	stress response;developmental processes;signal transduction;other biological processes	non-structural extracellular	signal transduction activity or receptor binding;other molecular function	13601	ENSMUSG00000028108	Ecm1	mmu:13601; Q3U5Q5; Q61508		Platelet degranulation	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	0.121600547823456	0.795351011232032	1.51989274634622E-7	0.592370654746194	74811.39241511819	5.132626536679041E7	6.196550035866306E7	3515293.344106073	1.1331897286900917E7
Cont_P04259	Keratin, type II cytoskeletal 6B OS=Homo sapiens OX=9606 GN=KRT6B PE=1 SV=5	126.901	47	30	442	4	564	60	cell organization and biogenesis;other biological processes	cytosol;cytoskeleton	bone, tooth or skin structural activity;cytoskeletal activity	3854	ENSG00000185479	KRT6B	hsa:3854; P04259; P48669		Formation of the cornified envelope	0.857251372850113	0.868132360832926	0.758743075163871	0.801271130817871	0.340133476321195	0.937453377971347	0.00123883404563536	298970.1410949	1156058.5455969477	510017.07482617133	1115770.6869766254	854901.7358096777
P17182	Alpha-enolase [OS=Mus musculus]	126.804	60	19	244	16	434	47.1	other metabolic processes;developmental processes;other biological processes	plasma membrane;other membranes;cytosol;other cell component	nucleic acid binding activity;other molecular function	13806; 433182	ENSMUSG00000059040; ENSMUSG00000063524	Eno1	mmu:13806; mmu:433182; P17182; Q99KT7; Q9DCY7	Glycolysis and gluconeogenesis		1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.789540446904924	0.858218537342417	0.989544231571828	47358.53377381337	9473047.660860082	1.1146559483992001E7	1.3905788568310633E7	2.89416009584274E7
P08113	Endoplasmin [OS=Mus musculus]	126.346	39	26	329	25	802	92.4	cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes	non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cell component	signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function	22027	ENSMUSG00000020048	Hsp90b1	mmu:22027; P08113; P11427	Focal adhesion: PI3K-Akt-mTOR signaling pathway; Hypoxia-dependent self-renewal of myoblasts	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Scavenging by Class A Receptors; Trafficking and processing of endosomal TLR; Interleukin-4 and Interleukin-13 signaling	0.107476768049312	0.0104456807471941	1.50457038391225E-17	0.205304099107124	0.840785133352029	0.866766165039268	0.896996950298791	52582.03853978356	4030450.84914005	5006439.15200075	6037105.20140975	1.2434595462188734E7
P58252	Elongation factor 2 [OS=Mus musculus]	126.048	37	31	378	30	858	95.3	cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes	plasma membrane;other membranes;cytosol;translational apparatus;other cell component	cytoskeletal activity;translation activity;nucleic acid binding activity;other molecular function	13629	ENSMUSG00000034994	Eef2	mmu:13629; P58252; Q544E4	Translation factors	Neutrophil degranulation; Protein methylation; Peptide chain elongation; Synthesis of diphthamide-EEF2	0.299809054080284	0.188334321166369	0.471929633209224	0.84258396038376	0.97504218639442	0.866546043492515	0.950878070645738	229633.38558146535	6414138.274151959	1.0566307796994643E7	4859646.5618234025	1.3065706600835832E7
Cont_P02538	Keratin, type II cytoskeletal 6A OS=Homo sapiens OX=9606 GN=KRT6A PE=1 SV=3	123.757	47	30	454	3	564	60	cell organization and biogenesis;stress response;other biological processes	cytosol;cytoskeleton	bone, tooth or skin structural activity;cytoskeletal activity	3853	ENSG00000205420	KRT6A	A4QPC1; hsa:3853; P02538; P48667; Q08AR4; Q6NT67; Q96CL4	Ectoderm differentiation; Ectoderm differentiation; Pancreatic cancer subtypes	Formation of the cornified envelope	0.892533464536408	0.964633336683333	0.745886066139481	0.84258396038376	0.574739141583974	0.709593139419252	5.66461038960431E-4	2182876.549653717	4785085.111074816	3779160.7730984767	8485501.699692694	3982846.61307857
P97298	Pigment epithelium-derived factor [OS=Mus musculus]	123.502	47	16	346	12	417	46.2	cell cycle OR cell proliferation;developmental processes;other biological processes	non-structural extracellular;extracellular matrix;other cell component	enzyme regulator activity	20317	ENSMUSG00000000753	Serpinf1	mmu:20317; O70629; O88691; P97298			1.65082956259427E-17	0.227296093012204	0.434748506750565	0.770205086382264	0.174886032348437	0.300753028734261	0.891044455497809	462579.17347644636	1.46490289953418E7	7.121805491857927E7	5921015.69252881	1.5757205380580032E7
Q70E20	Sushi, nidogen and EGF-like domain-containing protein 1 [OS=Mus musculus]	122.942	19	22	287	22	1403	151.5	cell adhesion	non-structural extracellular;extracellular matrix	other molecular function	208777		Sned1	A6H6I3; mmu:208777; Q70E20; Q810H2; Q8BMD9			1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.869908412860824	0.817293288705596	0.880760468933162	37861.533059704365	3293936.3484006864	6267209.5561869135	4995161.517920501	1.4223395042125002E7
P13020	Gelsolin [OS=Mus musculus]	122.934	35	22	377	9	780	85.9	cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes	non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component	cytoskeletal activity;other molecular function	227753	ENSMUSG00000026879	Gsn	mmu:227753; P13020; Q3UPB1; Q8R590	Regulation of actin cytoskeleton	Neutrophil degranulation; Caspase-mediated cleavage of cytoskeletal proteins	0.440427841758307	0.396306424610341	0.186266168629733	0.379422692457324	0.994546642862744	0.709593139419252	0.793590033024783	1139775.9088509877	6438031.44422588	9825643.045518672	1.1033925013460701E7	2.9144067496602204E7
Q61398	Procollagen C-endopeptidase enhancer 1 [OS=Mus musculus]	120.4	40	14	323	14	468	50.1	protein metabolism;other biological processes		enzyme regulator activity;other molecular function	18542	ENSMUSG00000029718	Pcolce	mmu:18542; O35113; Q61398	mRNA processing	Collagen biosynthesis and modifying enzymes; Crosslinking of collagen fibrils	1.65082956259427E-17	1.8644578313253E-17	0.151224536345852	0.288320039261486	0.789540446904924	0.0895861566882082	0.711902858921665	84503.2651712337	2.52047208020085E7	2.958750643636163E7	7672570.19904635	1.2538308810459368E7
P26039	Talin-1 [OS=Mus musculus]	118.226	15	30	153	30	2541	269.7	cell adhesion;cell organization and biogenesis;signal transduction	plasma membrane;other membranes;cytosol;cytoskeleton;other cell component	signal transduction activity or receptor binding;cytoskeletal activity;other molecular function	21894	ENSMUSG00000028465	Tln1	A2AIM8; mmu:21894; P26039; Q8VEF0	Primary focal segmental glomerulosclerosis (FSGS); Integrin-mediated cell adhesion; Focal adhesion	Platelet degranulation ; MAP2K and MAPK activation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; Smooth Muscle Contraction; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	0.958262397335385	0.994542145304377	0.680632778351053	0.738983404380581	0.783910800136359	0.87222702623065	0.535066779633529	147890.2697082064	165904.24421521465	567933.664164035	286851.2614141297	2291518.0404973766
Q8BPB5	EGF-containing fibulin-like extracellular matrix protein 1 [OS=Mus musculus]	117.738	49	15	220	15	493	54.9	protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes	extracellular matrix	signal transduction activity or receptor binding;kinase activity;other molecular function	216616	ENSMUSG00000020467	Efemp1	mmu:216616; Q6Y3N6; Q8BPB5			1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	0.376780684027729	0.983440558239231	0.145805028390539	0.982581944728745	29995.485006469138	4441372.613318663	7007290.288389671	1370373.3251651835	3606517.1409647237
P09411	Phosphoglycerate kinase 1 [OS=Mus musculus]	116.462	57	18	287	18	417	44.5	protein metabolism;other metabolic processes;stress response;other biological processes	non-structural extracellular;other membranes;cytosol;mitochondrion;other cell component	kinase activity;other molecular function	18655	ENSMUSG00000062070	Pgk1	mmu:18655; P09411; Q3TPE6; Q3UKV8; Q5XJE7	Glycolysis and gluconeogenesis	Gluconeogenesis; Glycolysis	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	1.70336894001643E-17	0.766862952867809	0.820281310709571	0.891044455497809	46750.53578358531	3210948.6178334034	3594147.655304653	4500077.619792943	1.4795712145397767E7
P27773	Protein disulfide-isomerase A3 [OS=Mus musculus]	115.891	55	23	291	23	505	56.6	cell adhesion;cell organization and biogenesis;stress response;signal transduction;other biological processes	non-structural extracellular;other membranes;ER/Golgi;other cell component	nucleic acid binding activity;other molecular function	14827	ENSMUSG00000027248	Pdia3	mmu:14827; P27773; Q3TEI9; Q3TIL2; Q3UZK8; Q8C2F4; Q99LF6		ER-Phagosome pathway; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Calnexin/calreticulin cycle	0.9135584231482	0.736536116100563	0.498293621965442	0.874168055361729	0.862063111456553	0.881496352314601	0.939046770372612	196243.61956605766	5161827.016313557	6480316.532156386	7238345.98431998	1.5315044241817234E7
P10107	Annexin A1 [OS=Mus musculus]	115.566	64	18	270	18	346	38.7	cell organization and biogenesis;stress response;transport;signal transduction;other biological processes	non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component	enzyme regulator activity;other molecular function	16952	ENSMUSG00000024659	Anxa1	mmu:16952; P10107	Spinal cord injury; Prostaglandin synthesis and regulation	G alpha (q) signalling events; G alpha (i) signalling events; Formyl peptide receptors bind formyl peptides and many other ligands	1.65082956259427E-17	0.105053536950499	1.50457038391225E-17	1.70336894001643E-17	0.401885831342676	0.529099828181544	0.924766494197286	8983.410658903753	1675870.316312303	6017153.19339518	4211649.667813237	1.08370832078509E7
Cont_Q2KJF1	Alpha-1B-glycoprotein OS=Bos taurus OX=9913 GN=A1BG PE=1 SV=1	115.502	48	14	224	14	503	53.5	signal transduction	non-structural extracellular;plasma membrane;other membranes		518955		A1BG	bta:518955; Q2KJF1		Platelet degranulation ; Neutrophil degranulation	0.635218461842139	0.655487072215252	0.641514600397631	0.360991986803736	0.696358249006924	0.601376052147163	0.891044455497809	9385194.584847162	9820849.23751892	8859077.038578315	6762503.63408608	1.0317459698123023E7
Cont_Q3MHN5	Vitamin D-binding protein OS=Bos taurus OX=9913 GN=GC PE=2 SV=1	113.599	55	20	319	20	474	53.3	other metabolic processes;transport	non-structural extracellular;other cell component	transporter activity;cytoskeletal activity;other molecular function	530076		GC	bta:530076; Q3MHN5			0.549057967251154	0.804331105646976	0.579435037816218	0.479472599858427	0.139718417146003	0.570795727084329	0.421365656927814	1.2784681703575822E7	1.5974245944817802E7	1.026921939097026E7	1.0785165311962552E7	1.4618596373270534E7
P17742	Peptidyl-prolyl cis-trans isomerase A [OS=Mus musculus]	113.527	60	9	369	9	164	18	cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes	non-structural extracellular;cytosol;nucleus;other cell component	signal transduction activity or receptor binding;other molecular function	268373	ENSMUSG00000071866	Ppia	mmu:268373; P17742; Q9CWJ5; Q9R137		Neutrophil degranulation; Basigin interactions	0.100219677394751	0.099382125133403	1.50457038391225E-17	1.70336894001643E-17	0.696358249006924	0.937453377971347	0.331144967260478	5533917.143041036	1.0145464905716315E7	3.610988970082183E7	1.0696784170781441E7	4.607074026803666E7
Q69ZN7	Myoferlin [OS=Mus musculus]	112.647	22	36	227	36	2048	233.2	cell organization and biogenesis;other metabolic processes;stress response;other biological processes	plasma membrane;other membranes;nucleus	other molecular function	226101	ENSMUSG00000048612	Myof	mmu:226101; Q69ZN7; Q7TMG0; Q80V33; Q8BU64; Q8BU70; Q8BUC1; Q8BVY6; Q8C0D1; Q8R3B4			0.73657372909066	0.964709887217926	0.888974672311279	0.930955411749965	0.877818946381645	0.609903091678244	0.975029032316037	74563.786625436	322363.41862436634	911704.7850761963	1104935.9693987637	3065805.015040973
P26041	Moesin [OS=Mus musculus]	112.068	47	28	353	19	577	67.7	cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes	plasma membrane;other membranes;cytosol;cytoskeleton;other cell component	signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function	17698	ENSMUSG00000031207	Msn	B1AX70; mmu:17698; P26041; Q3UL28; Q8BSN4	Regulation of actin cytoskeleton	Recycling pathway of L1	1.65082956259427E-17	0.0604972675946614	1.50457038391225E-17	0.157138696252226	0.682171843898269	0.97925982662951	0.954396180425051	3564499.916018247	9136364.2843242	1.7052591672350097E7	1.120013397828275E7	1.9030746620886367E7
P05064	Fructose-bisphosphate aldolase A [OS=Mus musculus]	112.015	66	18	261	18	364	39.3	cell organization and biogenesis;other metabolic processes;other biological processes	plasma membrane;other membranes;cytosol;cytoskeleton;other cell component	other molecular function	11674	ENSMUSG00000030695	Aldoa	mmu:11674; P05064	Glycolysis and gluconeogenesis	Platelet degranulation ; Neutrophil degranulation; Gluconeogenesis; Glycolysis	0.101571037453114	0.00616383846364181	1.50457038391225E-17	0.0771819601934254	0.828577692034317	0.988377544628277	0.953305976192702	21908.055682018665	4319055.57861477	4893427.94836492	4518789.603964283	1.0653934694757948E7
B2RQC6	Multifunctional protein CAD [OS=Mus musculus]	111.853	18	32	111	32	2225	243.1	other metabolic processes;stress response;transport;developmental processes;other biological processes	cytosol;nucleus;other cell component	kinase activity;other molecular function	69719	ENSMUSG00000013629	Cad	B2RQC6; B7ZN27; mmu:69719	Mechanisms associated with pluripotency	Pyrimidine biosynthesis	0.69394578118832	0.6681512188534	0.666244110962191	0.963127218853016	0.968897093792999	0.798180783050573	0.621633895543644	34439.61575478624	448793.6641228067	957747.5456383955	139659.55402474166	452794.3373622177
Q8BND5	Sulfhydryl oxidase 1 [OS=Mus musculus]	111.186	35	22	242	22	748	82.7	cell organization and biogenesis;other biological processes	non-structural extracellular;other membranes;ER/Golgi	other molecular function	104009	ENSMUSG00000033684	Qsox1	mmu:104009; Q3TDY9; Q3TE19; Q3TR29; Q3UEL4; Q8BND5; Q8K041; Q9DBL6		Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Neutrophil degranulation	1.65082956259427E-17	1.8644578313253E-17	1.50457038391225E-17	0.162753188077458	0.696358249006924	0.331332346840573	0.877612009404373	25068.200750320597	3849451.1157268733	1.052758137572049E7	1818282.5759143168	5040172.36278756

100

Accession

Description

Sum PEP Score

Biological Process

Cellular Component

Molecular Function

Entrez Gene ID

Ensembl Gene ID

Gene Symbol

Gene ID

WikiPathways

Reactome Pathways

Abundance Ratio Adj. P-Value: (LQ_6h) / (FM_control)

Abundance Ratio Adj. P-Value: (LQ_16h) / (FM_control)

FM_AVERAGE

LQ6h_AVERAGE

LQ16h_AVERAGE

FC_ LQ6h vs NC

FC_ LQ16h vs FM

P11276

Fibronectin [OS=Mus musculus]

867.353

cell adhesion;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes

non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi

signal transduction activity or receptor binding;enzyme regulator activity;other molecular function

14268

ENSMUSG00000026193

Fn1

G5E8B8; mmu:14268; P11276; Q61567; Q61568; Q61569; Q64233; Q80UI4

Focal adhesion: PI3K-Akt-mTOR signaling pathway; Inflammatory response pathway; Regulation of actin cytoskeleton; Comprehensive IL-17A signaling; Focal adhesion

ECM proteoglycans; Platelet degranulation ; Cell surface interactions at the vascular wall; Syndecan interactions; MAP2K and MAPK activation; Integrin cell surface interactions; Molecules associated with elastic fibres; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Fibronectin matrix formation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; Degradation of the extracellular matrix; Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells; MET activates PTK2 signaling; GPER1 signaling

0.00584906503121538

0.0844744457809114

2.76414533778046E7

2.022341523870097E8

2.12696235413058E8

2.8711212743884964

2.9438891195215318

P11087

Collagen alpha-1(I) chain [OS=Mus musculus]

797.017

cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes

non-structural extracellular;extracellular matrix;other cell component

extracellular structural activity;other molecular function

12842

ENSMUSG00000001506

Col1a1

mmu:12842; P11087; Q53WT0; Q60635; Q61367; Q61427; Q63919; Q6PCL3; Q810J9

Osteoblast signaling; Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Comprehensive IL-17A signaling; Focal adhesion

Cell surface interactions at the vascular wall; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ECM proteoglycans; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; GPVI-mediated activation cascade; GP1b-IX-V activation signalling; Platelet Adhesion to exposed collagen; Platelet Aggregation (Plug Formation); MET activates PTK2 signaling

1.8644578313253E-17

1.65082956259427E-17

772438.0834537543

2.0798706453114033E8

5.92854376184685E8

8.07285879426701

9.58404276622316

Q01149

Collagen alpha-2(I) chain [OS=Mus musculus]

773.662

cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes

non-structural extracellular;extracellular matrix;other cell component

extracellular structural activity;other molecular function

12843

ENSMUSG00000029661

Col1a2

mmu:12843; Q01149; Q8CGA5

Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Focal adhesion

Crosslinking of collagen fibrils; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; ECM proteoglycans; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; GPVI-mediated activation cascade; GP1b-IX-V activation signalling; Platelet Adhesion to exposed collagen; Platelet Aggregation (Plug Formation); MET activates PTK2 signaling

1.8644578313253E-17

1.65082956259427E-17

182180.3275564673

1.7308392932505235E8

3.475967473053053E8

9.891888882254342

10.89783168612198

P08121

Collagen alpha-1(III) chain [OS=Mus musculus]

695.631

cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes

extracellular matrix;other cell component

signal transduction activity or receptor binding;extracellular structural activity;other molecular function

12825

ENSMUSG00000026043

Col3a1

mmu:12825; P08121; Q61429; Q9CRN7

Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Focal adhesion

Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ECM proteoglycans; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; MET activates PTK2 signaling

1.8644578313253E-17

1.65082956259427E-17

454748.1180174556

6.282890624937943E7

2.8394661715058166E8

7.110216987795516

9.286336341446717

Q9QXS1

Plectin [OS=Mus musculus]

659.702

cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes

plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component

cytoskeletal activity;other molecular function

18810

ENSMUSG00000022565

Plec

E9QN87; mmu:18810; Q6S384; Q6S389; Q6S394; Q9CS65; Q9QUT2; Q9QXQ8; Q9QXQ9; Q9QXR0; Q9QXR1; Q9QXR2; Q9QXR3; Q9QXR4; Q9QXR5; Q9QXR6; Q9QXR7; Q9QXR8; Q9QXR9; Q9QXS0; Q9QXS1; Q9QXS2; Q9QXS3

Alpha 6 beta 4 integrin signaling pathway; EGFR1 signaling pathway

Type I hemidesmosome assembly; Caspase-mediated cleavage of cytoskeletal proteins

0.714932595871944

0.481729871164266

309922.514176982

4599273.114185064

1.6676006673579365E7

3.891426402670929

5.749722481744953

P08122

Collagen alpha-2(IV) chain [OS=Mus musculus]

526.992

RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes

non-structural extracellular;extracellular matrix

extracellular structural activity

12827

ENSMUSG00000031503

Col4a2

mmu:12827; P08122; Q3B7C2; Q3TPV9; Q61375; Q66JS5; Q6RCT6; Q6RCT7; Q6U9X1; Q8BPI9; Q8BPK3; Q91VI3

Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Focal adhesion

Laminin interactions; Signaling by PDGF; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions

0.64759425713406

0.352816378116182

1393534.8123072747

1.3981747232493034E7

5.0194805286054574E7

3.3267237103227703

5.170717117454539

Q3U962

Collagen alpha-2(V) chain [OS=Mus musculus]

518.514

cell organization and biogenesis;developmental processes;other biological processes

extracellular matrix;other cell component

extracellular structural activity;other molecular function

12832

ENSMUSG00000026042

Col5a2

mmu:12832; Q3TVR2; Q3U962; Q3UHK7; Q3UTT4; Q3V1J6; Q61431; Q7TMS0; Q80VS8

Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion

Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions

0.961254912149485

0.861384746267066

2.4419841082594533E7

1.5753424919239333E7

4.592471970087584E7

-0.6323882956741324

0.9112171042444063

Q05793

Basement membrane-specific heparan sulfate proteoglycan core protein [OS=Mus musculus]

507.28

cell organization and biogenesis;transport;developmental processes;other biological processes

non-structural extracellular;extracellular matrix;ER/Golgi

other molecular function

15530

Hspg2

mmu:15530; Q05793

0.382764581022518

0.332090710292395

171009.25706548532

2.1355561683383033E7

4.109385814368304E7

6.964393610173966

7.908704552577742

Q61554

Fibrillin-1 [OS=Mus musculus]

499.202

cell adhesion;other metabolic processes;developmental processes;signal transduction;other biological processes

non-structural extracellular;extracellular matrix

signal transduction activity or receptor binding;extracellular structural activity;other molecular function

14118

ENSMUSG00000027204

Fbn1

A2AQ53; mmu:14118; Q60826; Q61554

Comprehensive IL-17A signaling

Integrin cell surface interactions; Degradation of the extracellular matrix; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; TGF-beta receptor signaling activates SMADs; Molecules associated with elastic fibres

0.0840496117897429

0.0596853092747711

81731.837224874

2.17735814942991E7

5.216417896597137E7

8.057464853046588

9.317945570971949

Q8BTM8

Filamin-A [OS=Mus musculus]

493.069

cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes

plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component

signal transduction activity or receptor binding;cytoskeletal activity;other molecular function

192176

ENSMUSG00000031328

Flna

B7FAV0; O54934; Q7TQI1; Q8BLK1; Q8BTM8; Q8BTN7; Q8VHX5; Q8VHX8; Q99KQ2

Mapk signaling pathway; Focal adhesion

Platelet degranulation ; Cell-extracellular matrix interactions; RHO GTPases activate PAKs; GP1b-IX-V activation signalling

0.493514006575528

0.0844935092512095

218480.8558628913

4952287.405198824

1.1395384793048913E7

4.502516267694667

5.704798960580473

P02463

Collagen alpha-1(IV) chain [OS=Mus musculus]

487.707

cell organization and biogenesis;developmental processes;signal transduction;other biological processes

non-structural extracellular;extracellular matrix

extracellular structural activity;other molecular function

12826

ENSMUSG00000031502

Col4a1

mmu:12826; P02463; Q3UHJ4; Q3UJE7; Q3UQV2; Q53X35; Q6GQS7; Q6PHB5; Q99LQ8

Spinal cord injury; Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion

0.68008321917751

0.604225174343649

262271.417553364

4620515.057112186

2.1463797748519864E7

4.138921184627833

6.3547009644888925

Q60847

Collagen alpha-1(XII) chain [OS=Mus musculus]

480.266

cell adhesion;developmental processes

other cell component

12816

ENSMUSG00000032332

Col12a1

mmu:12816; P70322; Q60847

Assembly of collagen fibrils and other multimeric structures; Collagen chain trimerization; Collagen degradation

1.8644578313253E-17

0.0975092237649803

80180.17821443231

5.1736330625803865E7

2.9952489655588504E7

9.33371639573238

8.545214585562245

Q8VDD5

Myosin-9 [OS=Mus musculus]

418.364

cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;stress response;transport;developmental processes;other biological processes

plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component

signal transduction activity or receptor binding;cytoskeletal activity;other molecular function

17886

ENSMUSG00000022443

Myh9

mmu:17886; Q3UHT9; Q3UHU4; Q6KAN6; Q811I2; Q8VDD5

Primary focal segmental glomerulosclerosis (FSGS)

RHO GTPases activate PAKs; Regulation of actin dynamics for phagocytic cup formation

0.0382609387499984

0.156498497144098

100319.6147091511

5176534.940650649

8067345.413832072

5.68931109493806

6.32941841059592

Cont_P02453

Collagen alpha-1(I) chain OS=Bos taurus OX=9913 GN=COL1A1 PE=1 SV=3

414.689

cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes

non-structural extracellular;extracellular matrix;other cell component

extracellular structural activity;other molecular function

282187

ENSBTAG00000013103

COL1A1

bta:282187; P02453; Q3MHM2

Inflammatory response pathway; Osteoblast signaling; Focal adhesion

Fibronectin matrix formation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Collagen degradation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; Collagen chain trimerization; GPVI-mediated activation cascade; Platelet Aggregation (Plug Formation); Platelet Adhesion to exposed collagen; GP1b-IX-V activation signalling

0.579410556046386

0.800889767710788

228542.54091026666

3262486.7198886867

3910059.36528234

3.8354373904758865

4.096655873055708

Cont_P02769

Albumin OS=Bos taurus OX=9913 GN=ALB PE=1 SV=4

390.555

stress response;other biological processes

non-structural extracellular;other cell component

nucleic acid binding activity;other molecular function

280717

ALB

A5PJX3; bta:280717; O02787; P02769; P04277; Q3SZR2

0.650544967914241

0.520832629933248

2.7142766432154403E9

2.9099571807541137E9

2.4034772237737E9

0.10043015448628909

-0.17544463789319698

P01027

Complement C3 [OS=Mus musculus]

388.541

cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes

non-structural extracellular;other cell component

signal transduction activity or receptor binding;enzyme regulator activity

12266

ENSMUSG00000024164

mmu:12266; P01027; Q61370; Q80XP1

Complement activation, classical pathway; Tyrobp causal network in microglia; Comprehensive IL-17A signaling

Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade; Neutrophil degranulation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; G alpha (i) signalling events; Peptide ligand-binding receptors; Alternative complement activation; Activation of C3 and C5

0.729783028721347

0.712660037675161

3269916.660849947

1.6657146132333001E7

4.4549110086954266E7

2.348815473163776

3.7680708408856756

Cont_Q7SIH1

Alpha-2-macroglobulin OS=Bos taurus OX=9913 GN=A2M PE=1 SV=2

370.864

non-structural extracellular

enzyme regulator activity;other molecular function

513856

ENSBTAG00000018137

A2M

A8E647; bta:513856; Q7SIH1

IL-6 signaling pathway

0.839052280267302

0.688450665125024

5.423624331449187E7

7.564994624258716E7

7.018676700369896E7

0.48008180391196364

0.37194179744919537

Cont_Q29443

Serotransferrin OS=Bos taurus OX=9913 GN=TF PE=2 SV=1

343.183

stress response;transport;other biological processes

non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle

other molecular function

280705

bta:280705; Q0IIK2; Q29443

0.964709887217926

0.615274986253429

1.48932090998098E8

2.32106703986673E8

1.5606409762411097E8

0.6401335422147162

0.06748403432742182

Cont_P07589

Fibronectin OS=Bos taurus OX=9913 GN=FN1 PE=1 SV=4

337.517

cell adhesion;cell organization and biogenesis;stress response;developmental processes;other biological processes

non-structural extracellular

signal transduction activity or receptor binding;other molecular function

FN1

P07589

0.525827426782658

0.714071857030863

166255.75410196633

835883.8306505851

952169.9232567847

2.329898180493011

2.5178147853003274

Q80X90

Filamin-B [OS=Mus musculus]

335.882

cell organization and biogenesis;stress response;other biological processes

plasma membrane;other membranes;cytosol;cytoskeleton;other cell component

cytoskeletal activity;other molecular function

286940

ENSMUSG00000025278

Flnb

E9QNV9; mmu:286940; Q80X90; Q8VHX4; Q8VHX7; Q99KY3

ISG15 antiviral mechanism

0.238365792894698

0.296944306247309

154624.23024854946

2351112.5534752235

6048828.490809467

3.926505287666639

5.289817436625841

Cont_P35527

Keratin, type I cytoskeletal 9 OS=Homo sapiens OX=9606 GN=KRT9 PE=1 SV=3

310.424

cell organization and biogenesis;other biological processes

cytosol;cytoskeleton

cytoskeletal activity

3857

ENSG00000171403

KRT9

hsa:3857; O00109; P35527; Q0IJ47; Q14665

Formation of the cornified envelope

0.73072258897653

0.836660982916281

2.9224080803851068E7

3.250630567014273E7

4.1318104811136335E7

0.1535619557424608

0.4996164340004211

Cont_P04264

Keratin, type II cytoskeletal 1 OS=Homo sapiens OX=9606 GN=KRT1 PE=1 SV=6

306.58

cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes

non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component

bone, tooth or skin structural activity;other molecular function

3848

ENSG00000167768

KRT1

B2RA01; hsa:3848; P04264; P85925; P86104; Q14720; Q6GSJ0; Q9H298

Corticotropin-releasing hormone signaling

Formation of the cornified envelope; Neutrophil degranulation; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin

0.653826967689551

0.65780924735352

1.5397854514739665E8

1.3414412508194733E8

1.6528138436319932E8

-0.1989454723145774

0.10219489843707631

P06909

Complement factor H [OS=Mus musculus]

292.01

cell adhesion;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes

non-structural extracellular;plasma membrane;other membranes;mitochondrion;other cell component

other molecular function

12628

ENSMUSG00000026365

Cfh

mmu:12628; P06909; Q6NZK3

Regulation of Complement cascade

0.0359547312524068

0.205200089226065

59542.32714759521

1.0566840244224759E7

1.036081717107911E7

7.471412714259086

7.443006470545328

P16546

Spectrin alpha chain, non-erythrocytic 1 [OS=Mus musculus]

291.854

cell organization and biogenesis

plasma membrane;other membranes;cytosol;cytoskeleton;other cell component

cytoskeletal activity;other molecular function

20740

ENSMUSG00000057738

Sptan1

A3KGU6; A3KGU8; P16546; Q8K380; Q9CT05

FAS pathway and stress induction of HSP regulation

Neutrophil degranulation; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Interaction between L1 and Ankyrins; COPI-mediated anterograde transport; RHOU GTPase cycle; RHOV GTPase cycle; Caspase-mediated cleavage of cytoskeletal proteins

0.786160319109602

0.958962194559628

684626.7741473566

1427277.73205798

3976922.979229001

1.0598764752393854

2.5382630028634425

Cont_P13645

Keratin, type I cytoskeletal 10 OS=Homo sapiens OX=9606 GN=KRT10 PE=1 SV=6

286.713

cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes

plasma membrane;cytosol;cytoskeleton;other cell component

bone, tooth or skin structural activity;other molecular function

3858

ENSG00000186395

KRT10

hsa:3858; P13645; Q14664; Q8N175

Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin

0.490821286240141

0.600890052902075

1.1091978559495355E8

9.409796786421584E7

1.13950700113199E8

-0.23728126077989872

0.0388930557490876

Cont_P35908

Keratin, type II cytoskeletal 2 epidermal OS=Homo sapiens OX=9606 GN=KRT2 PE=1 SV=2

284.975

cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes

plasma membrane;cytosol;cytoskeleton;other cell component

bone, tooth or skin structural activity;cytoskeletal activity

3849

ENSG00000172867

KRT2

hsa:3849; P35908; Q4VAQ2

Formation of the cornified envelope

0.411258958244596

0.499413631103761

4.776750778997586E7

2.9357809740500167E7

3.415287514761583E7

-0.702285269017387

-0.4840225715664078

Q62059

Versican core protein [OS=Mus musculus]

279.715

cell adhesion;developmental processes

non-structural extracellular;extracellular matrix;other cell component

other molecular function

Vcan

Q62058; Q62059; Q9CUU0

ECM proteoglycans; Glycosaminoglycan-protein linkage region biosynthesis; CS/DS degradation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; CS-GAG biosynthesis; DS-GAG biosynthesis

1.8644578313253E-17

1.65082956259427E-17

104188.56292801573

9.037034497028168E7

9.467651077277745E7

9.760508702070462

9.827665809842685

P10493

Nidogen-1 [OS=Mus musculus]

275.191

cell adhesion;cell organization and biogenesis;developmental processes;other biological processes

non-structural extracellular;extracellular matrix;other cell component

other molecular function

18073

ENSMUSG00000005397

Nid1

mmu:18073; P10493; Q3TKX9; Q8BQI3; Q8C3U8; Q8C9P6

Laminin interactions; Degradation of the extracellular matrix

1.8644578313253E-17

1.65082956259427E-17

322455.2944414853

1.2120394496125467E8

1.2671518083095133E8

8.554121783692475

8.618274500807305

O88207

Collagen alpha-1(V) chain [OS=Mus musculus]

275.025

cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes

extracellular matrix;other cell component

extracellular structural activity;other molecular function

12831

ENSMUSG00000026837

Col5a1

A3KGE3; mmu:12831; O88207; Q3UG94; Q6F6B0

Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion

ECM proteoglycans; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; MET activates PTK2 signaling

1.8644578313253E-17

1.65082956259427E-17

80388.83753211687

3577832.3612721

8562033.320911517

5.475946792986802

6.734814451334498

P37889

Fibulin-2 [OS=Mus musculus]

269.894

other biological processes

non-structural extracellular

other molecular function

14115

ENSMUSG00000064080

Fbln2

G5E8B3; mmu:14115; P37889; Q9WUI2

Molecules associated with elastic fibres

0.0640195441309023

1.65082956259427E-17

362692.0010392267

6.556805587417743E7

8.021475911820169E7

7.498104380777058

7.78897897175684

Q8VHX6

Filamin-C [OS=Mus musculus]

249.498

cell organization and biogenesis;other biological processes

plasma membrane;other membranes;cytosol;cytoskeleton;other cell component

cytoskeletal activity

68794

ENSMUSG00000068699

Flnc

B2RY80; B9EKT2; mmu:68794; Q6PAI6; Q8VHX6; Q9JJ38

Cell-extracellular matrix interactions

0.719627996749639

0.562594032195739

406087.97266412666

1016453.1391661359

2089599.8263247435

1.3236795012500113

2.3633624781914326

Q04857

Collagen alpha-1(VI) chain [OS=Mus musculus]

248.981

cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes

non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component

other molecular function

12833

ENSMUSG00000001119

Col6a1

mmu:12833; Q04857

ECM proteoglycans; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Signaling by PDGF; NCAM1 interactions

0.392208211277376

0.2534363617947

76865.2077476112

5.0068940213435836E7

6.914260176814564E7

9.34736947879783

9.813028451743143

Cont_Q2UVX4

Complement C3 OS=Bos taurus OX=9913 GN=C3 PE=1 SV=2

247.154

cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes

non-structural extracellular;other cell component

signal transduction activity or receptor binding;enzyme regulator activity

280677

ENSBTAG00000017280

bta:280677; Q2KIZ4; Q2UVX4

Complement and coagulation cascades; Complement activation, classical pathway

Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Neutrophil degranulation; Peptide ligand-binding receptors; G alpha (i) signalling events; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade; Alternative complement activation; Activation of C3 and C5

0.798729234704005

0.615680953989958

1.4686759191254234E7

1.84550126489547E7

1.5291804049274266E7

0.329496643269344

0.058242535434261965

Q62261

Spectrin beta chain, non-erythrocytic 1 [OS=Mus musculus]

244.684

cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes

plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component

cytoskeletal activity;other molecular function

20742

ENSMUSG00000020315

Sptbn1

A2AFU1; mmu:20742; Q3TEM7; Q5SQL8; Q5SQL9; Q62261; Q9QWJ7

COPI-mediated anterograde transport; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; RHOU GTPase cycle; Interaction between L1 and Ankyrins; RHOV GTPase cycle

0.776437620310661

0.69394578118832

492454.03878621367

920886.7046363313

2921004.358024217

0.9030345918205293

2.568403522778103

Q640N1

Adipocyte enhancer-binding protein 1 [OS=Mus musculus]

239.707

protein metabolism;other biological processes

nucleus;other cell component

nucleic acid binding activity;other molecular function

11568

ENSMUSG00000020473

Aebp1

mmu:11568; O88442; Q3TVV5; Q3TWA7; Q3TX56; Q3TXB2; Q5NCI9; Q61281; Q640N1

0.0457359864845759

0.269326617826563

4843934.666021533

3.9556778473622136E7

4.1143769603117764E7

3.029673625475387

3.0864226685149996

P57780

Alpha-actinin-4 [OS=Mus musculus]

239.42

cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes

cytoskeleton;nucleus;other cell component

cytoskeletal activity;other molecular function

60595

ENSMUSG00000054808

Actn4

mmu:60595; P57780

Primary focal segmental glomerulosclerosis (FSGS)

Platelet degranulation

1.8644578313253E-17

1.65082956259427E-17

20900.169415734228

4580996.01302682

9830280.285985528

7.7760028602441835

8.877574105018988

Q7TPR4

Alpha-actinin-1 [OS=Mus musculus]

235.529

cell adhesion;cell organization and biogenesis;other biological processes

plasma membrane;other membranes;cytoskeleton;other cell component

signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function

109711

ENSMUSG00000015143

Actn1

mmu:109711; Q7TPR4

Regulation of actin cytoskeleton; Integrin-mediated cell adhesion; Focal adhesion

Platelet degranulation ; RHOF GTPase cycle; RHOBTB2 GTPase cycle; RHOD GTPase cycle; Regulation of cytoskeletal remodeling and cell spreading by IPP complex components

0.178726136005694

0.995554138371554

486802.1989182571

2525588.7379033365

6210475.170240924

2.3752121425876065

3.673296064913109

P02468

Laminin subunit gamma-1 [OS=Mus musculus]

230.882

cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes

non-structural extracellular;extracellular matrix;other cell component

extracellular structural activity;other molecular function

Lamc1

P02468

0.116315527815218

0.118212047511996

18104.5719498812

7327169.184632126

1.61740059690847E7

8.660758050441677

9.803107266380897

Q91ZX7

Prolow-density lipoprotein receptor-related protein 1 [OS=Mus musculus]

230.497

other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes

plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component

signal transduction activity or receptor binding;other molecular function

16971

Lrp1

mmu:16971; Q61291; Q91ZX7; Q920Y4

Statin pathway; Wnt signaling pathway

Scavenging of heme from plasma; Retinoid metabolism and transport

0.0181625429641231

1.65082956259427E-17

30670.78727387535

3548407.5296101067

7355877.025944923

6.854162701489687

7.9058883521099

Cont_P60712

Actin, cytoplasmic 1 OS=Bos taurus OX=9913 GN=ACTB PE=1 SV=1

225.45

cell organization and biogenesis;stress response;developmental processes;other biological processes

plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component

enzyme regulator activity;cytoskeletal activity;other molecular function

100033878; 100135470; 100173832; 101844587; 102139853; 11461; 118833809; 280979; 396526; 403580; 414396; 443052; 450133; 60; 81822

ENSBTAG00000026199; ENSCAFG00000016020; ENSCAFG00030015381; ENSCAFG00040015695; ENSCPOG00000013467; ENSG00000075624; ENSMAUG00000008763; ENSMUSG00000029580; ENSOARG00040012985; ENSOARG00180022443; ENSOARG00185023855; ENSOARG00215030140; ENSOARG00225009314; ENSPPYG00000017336; ENSPTRG00000018890; ENSRNOG00000034254; ENSSSCG00000007585; ENSSSCG00030003451; ENSSSCG00035038792; ENSSSCG00040049462; ENSSSCG00045027458; ENSSSCG00050065025; ENSSSCG00055012597; ENSSSCG00060019124; ENSSSCG00065037921; ENSSSCG00070011353; ENSSSCG00105030144; ENSSSCG00110026965; ENSSSCG00115013637; ENSSSCG00130033784

Actb; ACTB

A5D961; A5PKA1; bta:280979; cfa:403580; cpoc:100135470; csab:103246953; ecb:100033878; gga:396526; hsa:60; maua:101844587; mmu:11461; O18840; oas:443052; P02570; P60706; P60707; P60708; P60709; P60710; P60711; P60712; P60713; P70514; P99021; pon:100173832; ptr:450133; Q11209; Q11211; Q3SZD2; Q3TI89; Q3TVP6; Q4L0Y2; Q4R561; Q5R1X3; Q5R582; Q5R6G0; Q64316; Q6QAQ1; Q6ZWM3; Q711N9; Q71FK5; Q75MN2; Q76N69; Q8MIJ0; Q8SPX4; Q95164; Q96B34; Q96HG5; rno:81822; ssc:414396

FAS pathway and stress induction of HSP regulation; Actin cytoskeleton regulation; Myometrial relaxation and contraction pathways; Focal adhesion; Arrhythmogenic right ventricular cardiomyopathy; Pathogenic Escherichia coli infection; Common pathways underlying drug addiction; Myometrial relaxation and contraction pathways; Focal adhesion; Fas ligand pathway and stress induction of heat shock proteins; Pathogenic Escherichia coli infection; Arrhythmogenic right ventricular cardiomyopathy; Focal adhesion; Myometrial relaxation and contraction pathways; Regulation of actin cytoskeleton; Myometrial relaxation and contraction pathways; Ebola virus infection in host; Acute viral myocarditis; Thermogenesis; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Overlap between signal transduction pathways contributing to LMNA laminopathies; Pleural mesothelioma; Regulation of actin cytoskeleton; Network map of SARS-CoV-2 signaling; Regulation of actin cytoskeleton; Regulation of actin cytoskeleton; Focal adhesion

Formation of the canonical BAF (cBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); Regulation of actin dynamics for phagocytic cup formation; EPH-ephrin mediated repulsion of cells; Formation of annular gap junctions; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; RHO GTPases Activate Formins; RHOF GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; B-WICH complex positively regulates rRNA expression; Regulation of CDH1 Function; Formation of the dystrophin-glycoprotein complex (DGC); Formation of the canonical BAF (cBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); RHO GTPases Activate WASPs and WAVEs; UCH proteinases; DNA Damage Recognition in GG-NER; Formation of the non-canonical BAF (ncBAF) complex; RHO GTPases activate IQGAPs; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Cell-extracellular matrix interactions; MAP2K and MAPK activation; Interaction between L1 and Ankyrins; RHOF GTPase cycle; DNA Damage Recognition in GG-NER; MAP2K and MAPK activation; RHO GTPases Activate Formins; Clathrin-mediated endocytosis; UCH proteinases; RHOF GTPase cycle; DNA Damage Recognition in GG-NER; EPH-ephrin mediated repulsion of cells; VEGFA-VEGFR2 Pathway; Regulation of actin dynamics for phagocytic cup formation; Adherens junctions interactions; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); RHO GTPases Activate WASPs and WAVEs; B-WICH complex positively regulates rRNA expression; Regulation of CDH1 Function; EPHB-mediated forward signaling; Formation of the non-canonical BAF (ncBAF) complex; Formation of the canonical BAF (cBAF) complex; Formation of annular gap junctions; RHO GTPases activate IQGAPs; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; RHO GTPases Activate WASPs and WAVEs; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RHO GTPases activate IQGAPs; RHO GTPases Activate Formins; RHOF GTPase cycle; Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs); B-WICH complex positively regulates rRNA expression; Signaling by BRAF and RAF1 fusions; UCH proteinases; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; VEGFA-VEGFR2 Pathway; Formation of the dystrophin-glycoprotein complex (DGC); Factors involved in megakaryocyte development and platelet production; Regulation of MITF-M-dependent genes involved in pigmentation; Formation of the canonical BAF (cBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); EPH-ephrin mediated repulsion of cells; HATs acetylate histones; Interaction between L1 and Ankyrins; Prefoldin mediated transfer of substrate to CCT/TriC; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Adherens junctions interactions; Regulation of CDH1 Function; Formation of the non-canonical BAF (ncBAF) complex; DNA Damage Recognition in GG-NER; Formation of the polybromo-BAF (pBAF) complex; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Formation of annular gap junctions; Folding of actin by CCT/TriC; Cell-extracellular matrix interactions; MAP2K and MAPK activation; RHO GTPases Activate Formins; Recycling pathway of L1; RHO GTPases activate IQGAPs; Clathrin-mediated endocytosis; Formation of the dystrophin-glycoprotein complex (DGC); EPHB-mediated forward signaling; UCH proteinases; B-WICH complex positively regulates rRNA expression; Adherens junctions interactions; Formation of the non-canonical BAF (ncBAF) complex; Formation of annular gap junctions; Formation of the polybromo-BAF (pBAF) complex; VEGFA-VEGFR2 Pathway; Cell-extracellular matrix interactions; RHO GTPases Activate WASPs and WAVEs; Regulation of CDH1 Function; Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; UCH proteinases; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); Formation of the polybromo-BAF (pBAF) complex; B-WICH complex positively regulates rRNA expression; DNA Damage Recognition in GG-NER; Formation of the canonical BAF (cBAF) complex; RHO GTPases Activate Formins; Regulation of CDH1 Function; Interaction between L1 and Ankyrins; RHOF GTPase cycle; Formation of the non-canonical BAF (ncBAF) complex; Adherens junctions interactions; Formation of the dystrophin-glycoprotein complex (DGC); VEGFA-VEGFR2 Pathway; RHO GTPases Activate WASPs and WAVEs; Cell-extracellular matrix interactions; EPHB-mediated forward signaling; MAP2K and MAPK activation; Recycling pathway of L1; RHO GTPases activate IQGAPs; Formation of annular gap junctions; B-WICH complex positively regulates rRNA expression; UCH proteinases; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); MAP2K and MAPK activation; Formation of the polybromo-BAF (pBAF) complex; RHO GTPases Activate Formins; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases Activate WASPs and WAVEs; Formation of the dystrophin-glycoprotein complex (DGC); VEGFA-VEGFR2 Pathway; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; DNA Damage Recognition in GG-NER; RHOF GTPase cycle; Cell-extracellular matrix interactions; Adherens junctions interactions; Formation of the non-canonical BAF (ncBAF) complex; Formation of the canonical BAF (cBAF) complex; RHO GTPases activate IQGAPs; Regulation of CDH1 Function; Gap junction degradation; Formation of annular gap junctions; Regulation of actin dynamics for phagocytic cup formation; RHOF GTPase cycle; Clathrin-mediated endocytosis; RHO GTPases Activate Formins; Cell-extracellular matrix interactions; VEGFA-VEGFR2 Pathway; Adherens junctions interactions; RHO GTPases activate IQGAPs; UCH proteinases; EPHB-mediated forward signaling; MAP2K and MAPK activation; RHO GTPases Activate WASPs and WAVEs; Formation of the dystrophin-glycoprotein complex (DGC); Formation of annular gap junctions; Formation of the canonical BAF (cBAF) complex; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of the non-canonical BAF (ncBAF) complex; Regulation of CDH1 Function

1.8644578313253E-17

1.65082956259427E-17

1996659.4544256767

4.828873920581084E7

6.5074451419171505E7

4.596026599796858

5.0264310485118315

P63260

Actin, cytoplasmic 2 [OS=Mus musculus]

217.791

cell organization and biogenesis;stress response;developmental processes;other biological processes

non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component

cytoskeletal activity;other molecular function

11465

ENSMUSG00000062825

Actg1

mmu:11465; P02571; P14104; P63260; P99022

Myometrial relaxation and contraction pathways; Regulation of actin cytoskeleton; Focal adhesion

Platelet degranulation ; RHO GTPases activate IQGAPs; Adherens junctions interactions; Regulation of CDH1 Function; RHO GTPases Activate Formins; Regulation of actin dynamics for phagocytic cup formation; Interaction between L1 and Ankyrins; MAP2K and MAPK activation; Recycling pathway of L1; Clathrin-mediated endocytosis; Formation of the dystrophin-glycoprotein complex (DGC); EPHB-mediated forward signaling; RHOF GTPase cycle; Formation of annular gap junctions; VEGFA-VEGFR2 Pathway; Cell-extracellular matrix interactions; RHO GTPases Activate WASPs and WAVEs; RHOBTB2 GTPase cycle

1.8644578313253E-17

1.65082956259427E-17

145698.54484736864

254666.434448248

P33434

72 kDa type IV collagenase [OS=Mus musculus]

212.03

cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes

extracellular matrix;plasma membrane;other membranes;cytoskeleton;mitochondrion;nucleus;other cell component

other molecular function

17390

ENSMUSG00000031740

Mmp2

mmu:17390; P33434

Lung fibrosis; IL-3 signaling pathway; Matrix metalloproteinases

Collagen degradation; Extra-nuclear estrogen signaling; EPH-ephrin mediated repulsion of cells; Activation of Matrix Metalloproteinases

0.964209443670126

0.372996577396536

2.5908623508144036E7

2.11513119484971E7

6.116415043649567E7

-0.292685217123521

1.239253938445554

P19096

Fatty acid synthase [OS=Mus musculus]

203.372

other metabolic processes;stress response;other biological processes

plasma membrane;other membranes;cytosol;ER/Golgi;other cell component

other molecular function

14104

ENSMUSG00000025153

Fasn

B1ATU8; mmu:14104; P19096; Q6PB72; Q8C4Z0; Q9EQR0

Fatty acid biosynthesis; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-9 fatty acid synthesis; Elongation of (very) long chain fatty acids

Fatty acyl-CoA biosynthesis; Vitamin B5 (pantothenate) metabolism

0.847457711018997

0.66189768147619

102793.32580216101

1389784.0897720233

2729524.669883373

3.757042269214309

4.730831235531711

Cont_Q3SZ57

Alpha-fetoprotein OS=Bos taurus OX=9913 GN=AFP PE=2 SV=1

202.89

other metabolic processes;developmental processes;other biological processes

non-structural extracellular;other cell component

other molecular function

506011

ENSBTAG00000017131

AFP

bta:506011; Q3SZ57

Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation

0.82964085881652

0.540832988168188

3.8603879197485335E7

4.5317948160280704E7

3.6151020512819335E7

0.23133671517440235

-0.09470945341303746

P48678

Prelamin-A/C [OS=Mus musculus]

202.607

cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes

other membranes;cytoskeleton;nucleus;other cell component

other molecular function

16905

ENSMUSG00000028063

Lmna

B3RH23; B3RH24; mmu:16905; P11516; P48678; P97859; Q3TIH0; Q3TTS8; Q3U733; Q3U7I5; Q3UCA0; Q3UCJ8; Q3UCU3; Q91WF2; Q9DC21

Adipogenesis genes; FAS pathway and stress induction of HSP regulation

0.00670345592293191

1.65082956259427E-17

75722.11050192213

4134986.871037207

1.1058985470826533E7

5.771024316562613

7.190288704425306

Q02788

Collagen alpha-2(VI) chain [OS=Mus musculus]

202.37

cell adhesion;signal transduction;other biological processes

non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component

other molecular function

12834

ENSMUSG00000020241

Col6a2

mmu:12834; Q02788; Q05505; Q8C972; Q8K229

Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion

1.8644578313253E-17

0.175734701097799

121237.29953889274

4.136492509189963E7

5.21291258166705E7

8.414430536592976

8.748112233779976

P97927

Laminin subunit alpha-4 [OS=Mus musculus]

199.33

cell adhesion;developmental processes;other biological processes

non-structural extracellular;extracellular matrix;other cell component

signal transduction activity or receptor binding

16775

ENSMUSG00000019846

Lama4

mmu:16775; O88785; P70409; P97927; Q14BF2

Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion

Formation of the dystrophin-glycoprotein complex (DGC); Laminin interactions; MET activates PTK2 signaling

0.645007535999596

0.496649188935323

390078.69973194966

5125646.74812024

1.037511250312096E7

3.715896926492177

4.733217948190459

P20152

Vimentin [OS=Mus musculus]

183.446

cell organization and biogenesis;stress response;developmental processes;other biological processes

plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component

cytoskeletal activity;nucleic acid binding activity;other molecular function

22352

ENSMUSG00000026728

Vim

mmu:22352; O08704; P20152; Q8CCH1

Spinal cord injury; Primary focal segmental glomerulosclerosis (FSGS); Alpha 6 beta 4 integrin signaling pathway

Aggrephagy; Striated Muscle Contraction; Caspase-mediated cleavage of cytoskeletal proteins; RHOBTB1 GTPase cycle

0.0955146622024883

1.65082956259427E-17

1112472.104030337

7365249.698992513

3.3401280645601466E7

2.7269652767818724

4.908062353318758

Q64727

Vinculin [OS=Mus musculus]

182.753

cell adhesion;cell organization and biogenesis;developmental processes;other biological processes

plasma membrane;other membranes;cytoskeleton;other cell component

cytoskeletal activity;other molecular function

22330

ENSMUSG00000021823

Vcl

mmu:22330; Q64727; Q8BP32; Q8BS46; Q922C5; Q922D9

Primary focal segmental glomerulosclerosis (FSGS); IL-3 signaling pathway; Regulation of actin cytoskeleton; Integrin-mediated cell adhesion; Focal adhesion

Neutrophil degranulation; High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells; Platelet degranulation ; MAP2K and MAPK activation; Smooth Muscle Contraction; Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells; Regulation of CDH1 Function

0.190838415616571

0.208404050858596

126150.06188907423

1953982.7579073233

4840837.086136207

3.9532049177000044

5.262043723246207

Q8K4G1

Latent-transforming growth factor beta-binding protein 4 [OS=Mus musculus]

180.216

cell-cell signaling;cell organization and biogenesis;transport;signal transduction

non-structural extracellular;extracellular matrix

other molecular function

108075

ENSMUSG00000040488

Ltbp4

E9QPD9; mmu:108075; Q8K4G0; Q8K4G1

TGF-beta receptor signaling activates SMADs; Molecules associated with elastic fibres

0.362779483059131

0.308350896322176

50068.58855747415

1469976.6770863

2473680.681365607

4.875743668797631

5.626609683578324

Q68FD5

Clathrin heavy chain 1 [OS=Mus musculus]

180.117

cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes

plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component

nucleic acid binding activity;other molecular function

67300

ENSMUSG00000047126

Cltc

mmu:67300; Q68FD5

IL-7 signaling pathway; Kit receptor signaling pathway

MHC class II antigen presentation; Recycling pathway of L1; Cargo recognition for clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis; LDL clearance; Retrograde neurotrophin signalling; Formation of annular gap junctions; Lysosome Vesicle Biogenesis; WNT5A-dependent internalization of FZD4; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation; RHOU GTPase cycle; RHOV GTPase cycle

0.198232028950426

0.4248536990637

14581.209031729499

1426606.2225329466

2101059.0869428

6.612333012441563

7.170862575755155

P02469

Laminin subunit beta-1 [OS=Mus musculus]

179.863

cell adhesion;cell organization and biogenesis;developmental processes;other biological processes

non-structural extracellular;extracellular matrix;nucleus;other cell component

signal transduction activity or receptor binding;extracellular structural activity;other molecular function

16777

ENSMUSG00000002900

Lamb1

E9PXZ9; P02469

Focal adhesion: PI3K-Akt-mTOR signaling pathway; Inflammatory response pathway; Alpha 6 beta 4 integrin signaling pathway; Focal adhesion

0.341417478664423

0.205801242418232

1.0460538665187027E7

1.4326337702720901E7

1.8407714250900764E7

0.45371270995740953

0.8153533483670897

Q01853

Transitional endoplasmic reticulum ATPase [OS=Mus musculus]

179.055

cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;other biological processes

other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component

signal transduction activity or receptor binding;enzyme regulator activity;other molecular function

269523

ENSMUSG00000028452

Vcp

mmu:269523; Q01853; Q3TFH9; Q3TIM2; Q3TXN9; Q6PI18; Q8BSR6; Q8CEG4

IL-9 signaling pathway

RHOH GTPase cycle; Neutrophil degranulation; Protein methylation; Ovarian tumor domain proteases; Neddylation; ABC-family proteins mediated transport; Translesion Synthesis by POLH; Hedgehog ligand biogenesis; KEAP1-NFE2L2 pathway; HSF1 activation; N-glycan trimming in the ER and Calnexin/Calreticulin cycle; Josephin domain DUBs

0.645007535999596

0.915230778358139

621808.5300221853

5338414.413398174

9329554.935730066

3.101868991218387

3.9072659463434927

Q03350

Thrombospondin-2 [OS=Mus musculus]

178.303

cell adhesion;other biological processes

non-structural extracellular;extracellular matrix;other cell component

other molecular function

21826

ENSMUSG00000023885

Thbs2

mmu:21826; Q03350; Q8CG21

Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion

Signaling by PDGF; O-glycosylation of TSR domain-containing proteins

0.861805134687803

0.425958502904743

1929828.2171104867

7439397.130180354

1.1102887711296873E7

1.9467132814492152

2.524390613497798

Q80YX1

Tenascin [OS=Mus musculus]

175.9

cell adhesion;cell-cell signaling;cell organization and biogenesis;stress response;developmental processes;other biological processes

non-structural extracellular;extracellular matrix;other cell component

signal transduction activity or receptor binding;other molecular function

21923

ENSMUSG00000028364

Tnc

mmu:21923; Q64706; Q80YX1; Q80YX2

Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion

Integrin cell surface interactions; ECM proteoglycans; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation

0.827773046590747

0.117980756369098

20862.416559578665

1449614.4281484466

1.2106484504902953E7

6.118619130163546

9.18065799957951

Q61147

Ceruloplasmin [OS=Mus musculus]

175.43

cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes

non-structural extracellular

other molecular function

12870

ENSMUSG00000003617

mmu:12870; Q61147; Q6P5C8

0.0286042496128814

1.65082956259427E-17

116072.0240394514

4703216.257241024

9598922.193485493

5.340555472510453

6.369780225828648

Q3UQ28

Peroxidasin homolog [OS=Mus musculus]

173.636

cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes

extracellular matrix;ER/Golgi;other cell component

extracellular structural activity;other molecular function

69675

ENSMUSG00000020674

Pxdn

A4FU83; E9QNQ9; mmu:69675; Q3UQ28

Crosslinking of collagen fibrils

0.199060935853007

0.121749369203589

52188.79804577449

3468268.863888983

1.0141728842991263E7

6.054331756125822

7.602347715901429

Q61316

Heat shock 70 kDa protein 4 [OS=Mus musculus]

169.044

protein metabolism;other metabolic processes

other cell component

other molecular function

Hspa4

Q61316

Regulation of HSF1-mediated heat shock response

0.947627746595709

0.675982462193546

51496.56273693644

1715523.4149199834

3885769.0116153997

5.058028867603881

6.2375801933412385

Cont_P02533

Keratin, type I cytoskeletal 14 OS=Homo sapiens OX=9606 GN=KRT14 PE=1 SV=4

164.831

cell organization and biogenesis;other biological processes

plasma membrane;cytosol;cytoskeleton;nucleus;other cell component

cytoskeletal activity;other molecular function

3861

ENSG00000186847

KRT14

hsa:3861; P02533; Q14715; Q53XY3; Q9BUE3; Q9UBN2; Q9UBN3; Q9UCY4

Corticotropin-releasing hormone signaling

Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin; Developmental Lineage of Mammary Gland Myoepithelial Cells; Type I hemidesmosome assembly

0.880930298968675

0.821333803243143

6829492.454091667

1.0299655985485494E7

9892865.41378706

0.5927458802001806

0.5346100841122959

P11499

Heat shock protein HSP 90-beta [OS=Mus musculus]

164.719

cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes

non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component

enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function

15516

ENSMUSG00000023944

Hsp90ab1

mmu:15516; O89078; P11499; Q3UIQ7

Focal adhesion: PI3K-Akt-mTOR signaling pathway

Neutrophil degranulation; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of actin dynamics for phagocytic cup formation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Attenuation phase; Estrogen-dependent gene expression; Sema3A PAK dependent Axon repulsion; Aryl hydrocarbon receptor signalling; DDX58/IFIH1-mediated induction of interferon-alpha/beta; HSF1 activation; RHOBTB2 GTPase cycle; The NLRP3 inflammasome

1.8644578313253E-17

1.65082956259427E-17

166033.98771248801

1.0807613687705928E7

3.193268303009924E7

6.024425605817814

7.587411368791836

Q9JKF1

Ras GTPase-activating-like protein IQGAP1 [OS=Mus musculus]

163.926

cell organization and biogenesis;developmental processes;signal transduction;other biological processes

plasma membrane;other membranes;cytoskeleton;nucleus;other cell component

enzyme regulator activity;other molecular function

29875

ENSMUSG00000030536

Iqgap1

G3UW45; mmu:29875; Q9JKF1

G13 signaling pathway; Regulation of actin cytoskeleton

RHO GTPases activate IQGAPs; Neutrophil degranulation; RAC1 GTPase cycle; RAC2 GTPase cycle; RHOA GTPase cycle; MAP2K and MAPK activation; RHOQ GTPase cycle; RHOC GTPase cycle; RHOU GTPase cycle; RHOV GTPase cycle; Nephrin family interactions

0.794460986683881

0.930229675308081

58984.367745696

331165.4406654323

1068898.0084058929

2.489147563897488

4.1796477342414615

P52480

Pyruvate kinase PKM [OS=Mus musculus]

163.393

cell organization and biogenesis;other metabolic processes;other biological processes

cytosol;ER/Golgi;nucleus;other cell component

nucleic acid binding activity;kinase activity;other molecular function

18746

ENSMUSG00000032294

Pkm

mmu:18746; P52480; Q3TBV8; Q3TBW5; Q3TC59; Q3U1X3; Q3U5P6; Q4VC20; Q64484; Q91YI8; Q9CWB1

Glycolysis and gluconeogenesis; Purine metabolism

Neutrophil degranulation; Pyruvate metabolism; Glycolysis; Regulation of pyruvate metabolism

1.8644578313253E-17

1.65082956259427E-17

224031.9482756436

1.1706302394897154E7

1.6687028973496003E7

5.707437157684907

6.218878820280579

P63017

Heat shock cognate 71 kDa protein [OS=Mus musculus]

161.557

cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;other biological processes

non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component

signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function

15481

ENSMUSG00000015656

Hspa8

mmu:15481; P08109; P12225; P63017; Q3U6R0; Q3U764; Q3U7D7; Q3U7E2; Q3U9B4; Q3U9G0; Q3UGM0; Q5FWJ6; Q62373; Q62374; Q62375; Q6NZD0

Mapk signaling pathway; Exercise-induced circadian regulation

Neutrophil degranulation; mRNA Splicing - Major Pathway; Regulation of HSF1-mediated heat shock response; PKR-mediated signaling; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis; Attenuation phase; Lysosome Vesicle Biogenesis; GABA synthesis, release, reuptake and degradation; AUF1 (hnRNP D0) binds and destabilizes mRNA; Protein methylation

1.8644578313253E-17

1.65082956259427E-17

232221.67704249235

1.5723480869725833E7

2.2348098618015703E7

6.081274178280651

6.588505632754927

Q9JHU4

Cytoplasmic dynein 1 heavy chain 1 [OS=Mus musculus]

161.009

cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes

cytoskeleton;other cell component

cytoskeletal activity;other molecular function

13424

ENSMUSG00000018707

Dync1h1

E9QM71; mmu:13424; Q9JHU4

MHC class II antigen presentation; Neutrophil degranulation; Separation of Sister Chromatids; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; COPI-mediated anterograde transport; Recruitment of NuMA to mitotic centrosomes; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-independent Golgi-to-ER retrograde traffic; Aggrephagy; Anchoring of the basal body to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; AURKA Activation by TPX2

0.826895204418257

0.591873375996003

294620.0253220563

451351.8596347517

1275535.4534856554

0.6153970578330761

2.1141756003853147

Q99K41

EMILIN-1 [OS=Mus musculus]

157.011

cell adhesion;cell organization and biogenesis;developmental processes;other biological processes

non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component

signal transduction activity or receptor binding;extracellular structural activity;other molecular function

100952

ENSMUSG00000029163

Emilin1

mmu:100952; Q99K41

Molecules associated with elastic fibres

1.8644578313253E-17

1.65082956259427E-17

1671715.86234765

5498413.09956387

Q61879

Myosin-10 [OS=Mus musculus]

146

cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes

plasma membrane;other membranes;cytosol;cytoskeleton;other cell component

cytoskeletal activity;nucleic acid binding activity;other molecular function

77579

ENSMUSG00000020900

Myh10

mmu:77579; Q5SV63; Q61879

Regulation of actin cytoskeleton

RHO GTPases activate PAKs

0.506231596289679

0.705689538076567

123378.89612673952

266023.60455562966

458865.269073755

1.108458619642415

1.8949749715174342

Cont_P00761

Trypsin OS=Sus scrofa OX=9823 PE=1 SV=1

143.502

protein metabolism;other biological processes

non-structural extracellular

other molecular function

0.172153475402034

0.254996071775817

5.863252009900073E9

3.334729419178533E9

2.1792138371661735E9

-0.8141313613991668

-1.4278932978551737

P20029

Endoplasmic reticulum chaperone BiP [OS=Mus musculus]

142.966

protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes

non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component

enzyme regulator activity;translation activity;other molecular function

14828

ENSMUSG00000026864

Hspa5

mmu:14828; O35642; P20029; Q3UFF2; Q61630

Mapk signaling pathway

Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Regulation of HSF1-mediated heat shock response

1.8644578313253E-17

1.65082956259427E-17

7392689.481756757

8222965.927916382

Cont_P13647

Keratin, type II cytoskeletal 5 OS=Homo sapiens OX=9606 GN=KRT5 PE=1 SV=3

142.395

cell organization and biogenesis;other biological processes

cytosol;cytoskeleton;other cell component

bone, tooth or skin structural activity;cytoskeletal activity;other molecular function

3852

ENSG00000186081

KRT5

hsa:3852; P13647; Q6PI71; Q6UBJ0; Q8TA91

Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin; Developmental Lineage of Mammary Stem Cells; Developmental Lineage of Mammary Gland Myoepithelial Cells; Type I hemidesmosome assembly

0.847457711018997

0.786915923361782

5615099.536380176

7868513.182470503

9974982.226041706

0.4867794560282899

0.8290026737979193

Cont_P08779

Keratin, type I cytoskeletal 16 OS=Homo sapiens OX=9606 GN=KRT16 PE=1 SV=4

140.751

cell organization and biogenesis;stress response;other biological processes

plasma membrane;cytosol;cytoskeleton

cytoskeletal activity

3868

ENSG00000186832

KRT16

A8K488; hsa:3868; P08779; P30654; Q16402; Q9UBG8

Vitamin D receptor pathway

Formation of the cornified envelope

0.961351301268194

0.941324060398065

1275668.1444026066

3908256.3409277797

2249474.51763106

1.615272024678325

0.8183349524474691

Cont_P02465

Collagen alpha-2(I) chain OS=Bos taurus OX=9913 GN=COL1A2 PE=1 SV=2

139.99

non-structural extracellular;extracellular matrix

extracellular structural activity;other molecular function

282188

ENSBTAG00000013472

COL1A2

A6QP13; bta:282188; O62649; P02465

Inflammatory response pathway; Focal adhesion

0.876027096029978

0.483779141493222

70110.45197339094

85775.39066064726

163731.944383145

0.29093425615940965

1.223634381101149

Cont_P12763

Alpha-2-HS-glycoprotein OS=Bos taurus OX=9913 GN=AHSG PE=1 SV=2

132.772

stress response;other biological processes

non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component

enzyme regulator activity

280988

AHSG

A6QLF7; bta:280988; P12763

Neutrophil degranulation; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation

0.793013134473823

0.573667790345329

6.882384659684638E8

8.712402787486216E8

6.41500953397899E8

0.3401621263323422

-0.10145711777808486

P07901

Heat shock protein HSP 90-alpha [OS=Mus musculus]

132.382

cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes

plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component

signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function

15519

ENSMUSG00000021270

Hsp90aa1

mmu:15519; P07901

EBV LMP1 signaling; Focal adhesion: PI3K-Akt-mTOR signaling pathway; IL-6 signaling pathway; IL-2 signaling pathway

Regulation of necroptotic cell death; Recruitment of NuMA to mitotic centrosomes; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of actin dynamics for phagocytic cup formation; Neutrophil degranulation; Downregulation of ERBB2 signaling; Anchoring of the basal body to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; AURKA Activation by TPX2; Extra-nuclear estrogen signaling; Attenuation phase; Estrogen-dependent gene expression; Sema3A PAK dependent Axon repulsion; VEGFR2 mediated vascular permeability; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation; DDX58/IFIH1-mediated induction of interferon-alpha/beta; eNOS activation; HSF1 activation; RHOBTB2 GTPase cycle; Drug-mediated inhibition of ERBB2 signaling

0.508730894200713

1.65082956259427E-17

138049.65358917884

1667357.9717776468

3968795.71909318

3.594304702710527

4.845442133334701

Q02819

Nucleobindin-1 [OS=Mus musculus]

131.152

signal transduction

non-structural extracellular;other membranes;ER/Golgi

enzyme regulator activity;nucleic acid binding activity;other molecular function

18220

ENSMUSG00000030824

Nucb1

mmu:18220; Q02819; Q3TU42; Q9CWA1; Q9D8J4; Q9DBL3

Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation

1.8644578313253E-17

1.65082956259427E-17

30635.69892492515

5493436.34719679

1.9240052036173E7

7.4863513149475525

9.294683220219179

Q91V92

ATP-citrate synthase [OS=Mus musculus]

129.973

other metabolic processes

cytosol

other molecular function

104112

ENSMUSG00000020917

Acly

mmu:104112; Q91V92

Fatty acid biosynthesis

Neutrophil degranulation; Fatty acyl-CoA biosynthesis

0.371468864113786

0.230775890814232

27537.414327710998

1276919.6113413726

2339759.4103227933

5.535130791068342

6.408823278146731

A2ASQ1

Agrin [OS=Mus musculus]

128.989

cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes

non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cell component

signal transduction activity or receptor binding;other molecular function

11603

ENSMUSG00000041936

Agrn

A2ASP9; A2ASQ0; A2ASQ1; B2RWU1

Primary focal segmental glomerulosclerosis (FSGS)

ECM proteoglycans; Retinoid metabolism and transport; Glycosaminoglycan-protein linkage region biosynthesis; HS-GAG biosynthesis; HS-GAG degradation; Formation of the dystrophin-glycoprotein complex (DGC)

1.8644578313253E-17

1.65082956259427E-17

1695001.2322350666

3018900.06344302

Q61508

Extracellular matrix protein 1 [OS=Mus musculus]

127.379

stress response;developmental processes;signal transduction;other biological processes

non-structural extracellular

signal transduction activity or receptor binding;other molecular function

13601

ENSMUSG00000028108

Ecm1

mmu:13601; Q3U5Q5; Q61508

Platelet degranulation

1.8644578313253E-17

1.65082956259427E-17

74811.39241511819

5.132626536679041E7

6.196550035866306E7

9.422223591696405

9.69399151201845

Cont_P04259

Keratin, type II cytoskeletal 6B OS=Homo sapiens OX=9606 GN=KRT6B PE=1 SV=5

126.901

cell organization and biogenesis;other biological processes

cytosol;cytoskeleton

bone, tooth or skin structural activity;cytoskeletal activity

3854

ENSG00000185479

KRT6B

hsa:3854; P04259; P48669

Formation of the cornified envelope

0.868132360832926

0.857251372850113

298970.1410949

1156058.5455969477

510017.07482617133

1.9511411501265994

0.7705441417687864

P17182

Alpha-enolase [OS=Mus musculus]

126.804

other metabolic processes;developmental processes;other biological processes

plasma membrane;other membranes;cytosol;other cell component

nucleic acid binding activity;other molecular function

13806; 433182

ENSMUSG00000059040; ENSMUSG00000063524

Eno1

mmu:13806; mmu:433182; P17182; Q99KT7; Q9DCY7

Glycolysis and gluconeogenesis

1.8644578313253E-17

1.65082956259427E-17

47358.53377381337

9473047.660860082

1.1146559483992001E7

7.644060417133689

7.878758343175162

P08113

Endoplasmin [OS=Mus musculus]

126.346

cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes

non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cell component

signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function

22027

ENSMUSG00000020048

Hsp90b1

mmu:22027; P08113; P11427

Focal adhesion: PI3K-Akt-mTOR signaling pathway; Hypoxia-dependent self-renewal of myoblasts

0.0104456807471941

0.107476768049312

52582.03853978356

4030450.84914005

5006439.15200075

6.2602273439427725

6.573070961339852

P58252

Elongation factor 2 [OS=Mus musculus]

126.048

cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes

plasma membrane;other membranes;cytosol;translational apparatus;other cell component

cytoskeletal activity;translation activity;nucleic acid binding activity;other molecular function

13629

ENSMUSG00000034994

Eef2

mmu:13629; P58252; Q544E4

Translation factors

Neutrophil degranulation; Protein methylation; Peptide chain elongation; Synthesis of diphthamide-EEF2

0.188334321166369

0.299809054080284

229633.38558146535

6414138.274151959

1.0566307796994643E7

4.8038511446429455

5.523995125592705

Cont_P02538

Keratin, type II cytoskeletal 6A OS=Homo sapiens OX=9606 GN=KRT6A PE=1 SV=3

123.757

cell organization and biogenesis;stress response;other biological processes

cytosol;cytoskeleton

bone, tooth or skin structural activity;cytoskeletal activity

3853

ENSG00000205420

KRT6A

A4QPC1; hsa:3853; P02538; P48667; Q08AR4; Q6NT67; Q96CL4

Ectoderm differentiation; Ectoderm differentiation; Pancreatic cancer subtypes

Formation of the cornified envelope

0.964633336683333

0.892533464536408

2182876.549653717

4785085.111074816

3779160.7730984767

1.1323140432879846

0.7918353525552961

P97298

Pigment epithelium-derived factor [OS=Mus musculus]

123.502

cell cycle OR cell proliferation;developmental processes;other biological processes

non-structural extracellular;extracellular matrix;other cell component

enzyme regulator activity

20317

ENSMUSG00000000753

Serpinf1

mmu:20317; O70629; O88691; P97298

0.227296093012204

1.65082956259427E-17

462579.17347644636

1.46490289953418E7

7.121805491857927E7

4.984960915629733

7.266398910121059

Q70E20

Sushi, nidogen and EGF-like domain-containing protein 1 [OS=Mus musculus]

122.942

cell adhesion

non-structural extracellular;extracellular matrix

other molecular function

208777

Sned1

A6H6I3; mmu:208777; Q70E20; Q810H2; Q8BMD9

1.8644578313253E-17

1.65082956259427E-17

37861.533059704365

3293936.3484006864

6267209.5561869135

6.442936037948125

7.370946594278482

P13020

Gelsolin [OS=Mus musculus]

122.934

cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes

non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component

cytoskeletal activity;other molecular function

227753

ENSMUSG00000026879

Gsn

mmu:227753; P13020; Q3UPB1; Q8R590

Regulation of actin cytoskeleton

Neutrophil degranulation; Caspase-mediated cleavage of cytoskeletal proteins

0.396306424610341

0.440427841758307

1139775.9088509877

6438031.44422588

9825643.045518672

2.497869418910709

3.1078016243224496

Q61398

Procollagen C-endopeptidase enhancer 1 [OS=Mus musculus]

120.4

protein metabolism;other biological processes

enzyme regulator activity;other molecular function

18542

ENSMUSG00000029718

Pcolce

mmu:18542; O35113; Q61398

mRNA processing

Collagen biosynthesis and modifying enzymes; Crosslinking of collagen fibrils

1.8644578313253E-17

1.65082956259427E-17

84503.2651712337

2.52047208020085E7

2.958750643636163E7

8.220471170449764

8.451765311848972

P26039

Talin-1 [OS=Mus musculus]

118.226

cell adhesion;cell organization and biogenesis;signal transduction

plasma membrane;other membranes;cytosol;cytoskeleton;other cell component

signal transduction activity or receptor binding;cytoskeletal activity;other molecular function

21894

ENSMUSG00000028465

Tln1

A2AIM8; mmu:21894; P26039; Q8VEF0

Primary focal segmental glomerulosclerosis (FSGS); Integrin-mediated cell adhesion; Focal adhesion

Platelet degranulation ; MAP2K and MAPK activation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; Smooth Muscle Contraction; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion

0.994542145304377

0.958262397335385

147890.2697082064

165904.24421521465

567933.664164035

0.1658236593620016

1.9411952948940325

Q8BPB5

EGF-containing fibulin-like extracellular matrix protein 1 [OS=Mus musculus]

117.738

protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes

extracellular matrix

signal transduction activity or receptor binding;kinase activity;other molecular function

216616

ENSMUSG00000020467

Efemp1

mmu:216616; Q6Y3N6; Q8BPB5

1.8644578313253E-17

1.65082956259427E-17

29995.485006469138

4441372.613318663

7007290.288389671

7.210116443386737

7.867967494142903

P09411

Phosphoglycerate kinase 1 [OS=Mus musculus]

116.462

protein metabolism;other metabolic processes;stress response;other biological processes

non-structural extracellular;other membranes;cytosol;mitochondrion;other cell component

kinase activity;other molecular function

18655

ENSMUSG00000062070

Pgk1

mmu:18655; P09411; Q3TPE6; Q3UKV8; Q5XJE7

Glycolysis and gluconeogenesis

Gluconeogenesis; Glycolysis

1.8644578313253E-17

1.65082956259427E-17

46750.53578358531

3210948.6178334034

3594147.655304653

6.10187286968957

6.264522969777913

P27773

Protein disulfide-isomerase A3 [OS=Mus musculus]

115.891

cell adhesion;cell organization and biogenesis;stress response;signal transduction;other biological processes

non-structural extracellular;other membranes;ER/Golgi;other cell component

nucleic acid binding activity;other molecular function

14827

ENSMUSG00000027248

Pdia3

mmu:14827; P27773; Q3TEI9; Q3TIL2; Q3UZK8; Q8C2F4; Q99LF6

ER-Phagosome pathway; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Calnexin/calreticulin cycle

0.736536116100563

0.9135584231482

196243.61956605766

5161827.016313557

6480316.532156386

4.717164140703168

5.045346629722291

P10107

Annexin A1 [OS=Mus musculus]

115.566

cell organization and biogenesis;stress response;transport;signal transduction;other biological processes

non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component

enzyme regulator activity;other molecular function

16952

ENSMUSG00000024659

Anxa1

mmu:16952; P10107

Spinal cord injury; Prostaglandin synthesis and regulation

G alpha (q) signalling events; G alpha (i) signalling events; Formyl peptide receptors bind formyl peptides and many other ligands

0.105053536950499

1.65082956259427E-17

8983.410658903753

1675870.316312303

6017153.19339518

7.543431512773922

9.387602086782305

Cont_Q2KJF1

Alpha-1B-glycoprotein OS=Bos taurus OX=9913 GN=A1BG PE=1 SV=1

115.502

signal transduction

non-structural extracellular;plasma membrane;other membranes

518955

A1BG

bta:518955; Q2KJF1

Platelet degranulation ; Neutrophil degranulation

0.655487072215252

0.635218461842139

9385194.584847162

9820849.23751892

8859077.038578315

0.0654611269786279

-0.08323025407879855

Cont_Q3MHN5

Vitamin D-binding protein OS=Bos taurus OX=9913 GN=GC PE=2 SV=1

113.599

other metabolic processes;transport

non-structural extracellular;other cell component

transporter activity;cytoskeletal activity;other molecular function

530076

bta:530076; Q3MHN5

0.804331105646976

0.549057967251154

1.2784681703575822E7

1.5974245944817802E7

1.026921939097026E7

0.3213315885051744

-0.3160897225178924

P17742

Peptidyl-prolyl cis-trans isomerase A [OS=Mus musculus]

113.527

cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes

non-structural extracellular;cytosol;nucleus;other cell component

signal transduction activity or receptor binding;other molecular function

268373

ENSMUSG00000071866

Ppia

mmu:268373; P17742; Q9CWJ5; Q9R137

Neutrophil degranulation; Basigin interactions

0.099382125133403

0.100219677394751

5533917.143041036

1.0145464905716315E7

3.610988970082183E7

0.8744620282868188

2.706021065150085

Q69ZN7

Myoferlin [OS=Mus musculus]

112.647

cell organization and biogenesis;other metabolic processes;stress response;other biological processes

plasma membrane;other membranes;nucleus

other molecular function

226101

ENSMUSG00000048612

Myof

mmu:226101; Q69ZN7; Q7TMG0; Q80V33; Q8BU64; Q8BU70; Q8BUC1; Q8BVY6; Q8C0D1; Q8R3B4

0.964709887217926

0.73657372909066

74563.786625436

322363.41862436634

911704.7850761963

2.1121410056571723

3.6120197152096933

P26041

Moesin [OS=Mus musculus]

112.068

cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes

plasma membrane;other membranes;cytosol;cytoskeleton;other cell component

signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function

17698

ENSMUSG00000031207

Msn

B1AX70; mmu:17698; P26041; Q3UL28; Q8BSN4

Regulation of actin cytoskeleton

Recycling pathway of L1

0.0604972675946614

1.65082956259427E-17

3564499.916018247

9136364.2843242

1.7052591672350097E7

1.3579204878919158

2.258219426272545

P05064

Fructose-bisphosphate aldolase A [OS=Mus musculus]

112.015

cell organization and biogenesis;other metabolic processes;other biological processes

plasma membrane;other membranes;cytosol;cytoskeleton;other cell component

other molecular function

11674

ENSMUSG00000030695

Aldoa

mmu:11674; P05064

Glycolysis and gluconeogenesis

Platelet degranulation ; Neutrophil degranulation; Gluconeogenesis; Glycolysis

0.00616383846364181

0.101571037453114

21908.055682018665

4319055.57861477

4893427.94836492

7.623110619104784

7.803240194807217

B2RQC6

Multifunctional protein CAD [OS=Mus musculus]

111.853

other metabolic processes;stress response;transport;developmental processes;other biological processes

cytosol;nucleus;other cell component

kinase activity;other molecular function

69719

ENSMUSG00000013629

Cad

B2RQC6; B7ZN27; mmu:69719

Mechanisms associated with pluripotency

Pyrimidine biosynthesis

0.6681512188534

0.69394578118832

34439.61575478624

448793.6641228067

957747.5456383955

3.7039113570511004

4.797504471859518

Q8BND5

Sulfhydryl oxidase 1 [OS=Mus musculus]

111.186

cell organization and biogenesis;other biological processes

non-structural extracellular;other membranes;ER/Golgi

other molecular function

104009

ENSMUSG00000033684

Qsox1

mmu:104009; Q3TDY9; Q3TE19; Q3TR29; Q3UEL4; Q8BND5; Q8K041; Q9DBL6

Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Neutrophil degranulation

1.8644578313253E-17

1.65082956259427E-17

25068.200750320597

3849451.1157268733

1.052758137572049E7

7.262650488092563

8.714099860277624

100

Accession

Description

Sum PEP Score

Biological Process

Cellular Component

Molecular Function

Entrez Gene ID

Ensembl Gene ID

Gene Symbol

Gene ID

WikiPathways

Reactome Pathways

Abundance Ratio Adj. P-Value: (SQ_6h) / (FM)

Abundance Ratio Adj. P-Value: (SQ_16h) / (FM)

FM_AVERAGE

SQ6h_AVERAGE

SQ16h_AVERAGE

FC_ SQ6h vs FM

FC_ SQ16h vsFM

P11276

Fibronectin [OS=Mus musculus]

867.353

cell adhesion;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes

non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi

signal transduction activity or receptor binding;enzyme regulator activity;other molecular function

14268

ENSMUSG00000026193

Fn1

G5E8B8; mmu:14268; P11276; Q61567; Q61568; Q61569; Q64233; Q80UI4

Focal adhesion: PI3K-Akt-mTOR signaling pathway; Inflammatory response pathway; Regulation of actin cytoskeleton; Comprehensive IL-17A signaling; Focal adhesion

0.156115961659409

1.50457038391225E-17

2.76414533778046E7

1.26297193824042E8

2.74958241507436E8

2.191917205258659

1.1223899456264597

P11087

Collagen alpha-1(I) chain [OS=Mus musculus]

797.017

cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes

non-structural extracellular;extracellular matrix;other cell component

extracellular structural activity;other molecular function

12842

ENSMUSG00000001506

Col1a1

mmu:12842; P11087; Q53WT0; Q60635; Q61367; Q61427; Q63919; Q6PCL3; Q810J9

1.70336894001643E-17

1.50457038391225E-17

772438.0834537543

5.973622733379293E7

8.428319253806247E7

6.273043021175366

0.4966388360857373

Q01149

Collagen alpha-2(I) chain [OS=Mus musculus]

773.662

cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes

non-structural extracellular;extracellular matrix;other cell component

extracellular structural activity;other molecular function

12843

ENSMUSG00000029661

Col1a2

mmu:12843; Q01149; Q8CGA5

Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Focal adhesion

1.70336894001643E-17

1.50457038391225E-17

182180.3275564673

4.271481968913147E7

9.036410240893161E7

7.873225701670618

1.0810130762443846

P08121

Collagen alpha-1(III) chain [OS=Mus musculus]

695.631

cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes

extracellular matrix;other cell component

signal transduction activity or receptor binding;extracellular structural activity;other molecular function

12825

ENSMUSG00000026043

Col3a1

mmu:12825; P08121; Q61429; Q9CRN7

Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Focal adhesion

1.70336894001643E-17

1.50457038391225E-17

454748.1180174556

3.0365458724261332E7

6.6157215803336866E7

6.061219686329843

1.1234673567878595

Q9QXS1

Plectin [OS=Mus musculus]

659.702

cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes

plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component

cytoskeletal activity;other molecular function

18810

ENSMUSG00000022565

Plec

E9QN87; mmu:18810; Q6S384; Q6S389; Q6S394; Q9CS65; Q9QUT2; Q9QXQ8; Q9QXQ9; Q9QXR0; Q9QXR1; Q9QXR2; Q9QXR3; Q9QXR4; Q9QXR5; Q9QXR6; Q9QXR7; Q9QXR8; Q9QXR9; Q9QXS0; Q9QXS1; Q9QXS2; Q9QXS3

Alpha 6 beta 4 integrin signaling pathway; EGFR1 signaling pathway

Type I hemidesmosome assembly; Caspase-mediated cleavage of cytoskeletal proteins

0.572524806937582

0.336550483871782

309922.514176982

1.01501282886872E7

4.28490141732006E7

5.033446589054165

2.077764050729492

P08122

Collagen alpha-2(IV) chain [OS=Mus musculus]

526.992

RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes

non-structural extracellular;extracellular matrix

extracellular structural activity

12827

ENSMUSG00000031503

Col4a2

mmu:12827; P08122; Q3B7C2; Q3TPV9; Q61375; Q66JS5; Q6RCT6; Q6RCT7; Q6U9X1; Q8BPI9; Q8BPK3; Q91VI3

Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Focal adhesion

0.79866917976589

0.293387877727491

1393534.8123072747

1.701609057115766E7

5.972856146483746E7

3.6100786690336

1.8115213581142129

Q3U962

Collagen alpha-2(V) chain [OS=Mus musculus]

518.514

cell organization and biogenesis;developmental processes;other biological processes

extracellular matrix;other cell component

extracellular structural activity;other molecular function

12832

ENSMUSG00000026042

Col5a2

mmu:12832; Q3TVR2; Q3U962; Q3UHK7; Q3UTT4; Q3V1J6; Q61431; Q7TMS0; Q80VS8

Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion

0.632833892117728

0.730324052254867

2.4419841082594533E7

1.0471363011153279E7

2.1079551940947264E7

-1.221604567961347

1.009394958172112

Q05793

Basement membrane-specific heparan sulfate proteoglycan core protein [OS=Mus musculus]

507.28

cell organization and biogenesis;transport;developmental processes;other biological processes

non-structural extracellular;extracellular matrix;ER/Golgi

other molecular function

15530

Hspg2

mmu:15530; Q05793

0.553652046981626

0.771134174410141

171009.25706548532

8244737.341084313

1.8998181152407136E7

5.59132720511202

1.204315865984536

Q61554

Fibrillin-1 [OS=Mus musculus]

499.202

cell adhesion;other metabolic processes;developmental processes;signal transduction;other biological processes

non-structural extracellular;extracellular matrix

signal transduction activity or receptor binding;extracellular structural activity;other molecular function

14118

ENSMUSG00000027204

Fbn1

A2AQ53; mmu:14118; Q60826; Q61554

Comprehensive IL-17A signaling

0.84258396038376

0.378389090130589

81731.837224874

5145074.9913376765

2.082557122129057E7

5.976150130074537

2.017092057397419

Q8BTM8

Filamin-A [OS=Mus musculus]

493.069

plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component

signal transduction activity or receptor binding;cytoskeletal activity;other molecular function

192176

ENSMUSG00000031328

Flna

B7FAV0; O54934; Q7TQI1; Q8BLK1; Q8BTM8; Q8BTN7; Q8VHX5; Q8VHX8; Q99KQ2

Mapk signaling pathway; Focal adhesion

Platelet degranulation ; Cell-extracellular matrix interactions; RHO GTPases activate PAKs; GP1b-IX-V activation signalling

0.67528135146603

0.170420349138264

218480.8558628913

4296604.098486893

1.4686023116833666E7

4.297618073286841

1.7731750217306688

P02463

Collagen alpha-1(IV) chain [OS=Mus musculus]

487.707

cell organization and biogenesis;developmental processes;signal transduction;other biological processes

non-structural extracellular;extracellular matrix

extracellular structural activity;other molecular function

12826

ENSMUSG00000031502

Col4a1

mmu:12826; P02463; Q3UHJ4; Q3UJE7; Q3UQV2; Q53X35; Q6GQS7; Q6PHB5; Q99LQ8

Spinal cord injury; Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion

0.936818656936794

0.284160251285083

262271.417553364

8911949.32392111

3.3156314746725336E7

5.086608533309518

1.895470729077585

Q60847

Collagen alpha-1(XII) chain [OS=Mus musculus]

480.266

cell adhesion;developmental processes

other cell component

12816

ENSMUSG00000032332

Col12a1

mmu:12816; P70322; Q60847

Assembly of collagen fibrils and other multimeric structures; Collagen chain trimerization; Collagen degradation

0.162753188077458

0.344512840834051

80180.17821443231

1.0537780206453351E7

1.4629541968462234E7

7.038109654408597

0.473313607436834

Q8VDD5

Myosin-9 [OS=Mus musculus]

418.364

cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;stress response;transport;developmental processes;other biological processes

plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component

signal transduction activity or receptor binding;cytoskeletal activity;other molecular function

17886

ENSMUSG00000022443

Myh9

mmu:17886; Q3UHT9; Q3UHU4; Q6KAN6; Q811I2; Q8VDD5

Primary focal segmental glomerulosclerosis (FSGS)

RHO GTPases activate PAKs; Regulation of actin dynamics for phagocytic cup formation

0.15125389278925

0.118876667035285

100319.6147091511

7844465.70271172

1.9759662960152034E7

6.2889995690938765

1.3328112474161202

Cont_P02453

Collagen alpha-1(I) chain OS=Bos taurus OX=9913 GN=COL1A1 PE=1 SV=3

414.689

cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes

non-structural extracellular;extracellular matrix;other cell component

extracellular structural activity;other molecular function

282187

ENSBTAG00000013103

COL1A1

bta:282187; P02453; Q3MHM2

Inflammatory response pathway; Osteoblast signaling; Focal adhesion

0.839216523231753

0.58548007712969

228542.54091026666

1102058.9569362423

924822.5329095138

2.2696667672876303

-0.25295295191229616

Cont_P02769

Albumin OS=Bos taurus OX=9913 GN=ALB PE=1 SV=4

390.555

stress response;other biological processes

non-structural extracellular;other cell component

nucleic acid binding activity;other molecular function

280717

ALB

A5PJX3; bta:280717; O02787; P02769; P04277; Q3SZR2

0.497906326712893

0.598172767155558

2.7142766432154403E9

2.38097622607819E9

2.6841204207378564E9

-0.18901455448326657

0.1728961828070863

P01027

Complement C3 [OS=Mus musculus]

388.541

cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes

non-structural extracellular;other cell component

signal transduction activity or receptor binding;enzyme regulator activity

12266

ENSMUSG00000024164

mmu:12266; P01027; Q61370; Q80XP1

Complement activation, classical pathway; Tyrobp causal network in microglia; Comprehensive IL-17A signaling

0.762068821001752

0.506101547380209

3269916.660849947

3.6733221642207734E7

8.026680998659676E7

3.489759659547301

1.127718130841963

Cont_Q7SIH1

Alpha-2-macroglobulin OS=Bos taurus OX=9913 GN=A2M PE=1 SV=2

370.864

non-structural extracellular

enzyme regulator activity;other molecular function

513856

ENSBTAG00000018137

A2M

A8E647; bta:513856; Q7SIH1

IL-6 signaling pathway

0.509007335932165

0.731111241255251

5.423624331449187E7

5.23492843648457E7

8.250822323914327E7

-0.05108743825416383

0.6563680986370192

Cont_Q29443

Serotransferrin OS=Bos taurus OX=9913 GN=TF PE=2 SV=1

343.183

stress response;transport;other biological processes

non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle

other molecular function

280705

bta:280705; Q0IIK2; Q29443

0.571407162236119

0.600414647182016

1.48932090998098E8

1.3567523181654152E8

1.6257112433260167E8

-0.13449727704256245

0.2609136568979289

Cont_P07589

Fibronectin OS=Bos taurus OX=9913 GN=FN1 PE=1 SV=4

337.517

cell adhesion;cell organization and biogenesis;stress response;developmental processes;other biological processes

non-structural extracellular

signal transduction activity or receptor binding;other molecular function

FN1

P07589

0.802863674292211

0.94971810013306

166255.75410196633

482619.7682389803

602598.7403397557

1.5374827368819515

0.32031064720373065

Q80X90

Filamin-B [OS=Mus musculus]

335.882

cell organization and biogenesis;stress response;other biological processes

plasma membrane;other membranes;cytosol;cytoskeleton;other cell component

cytoskeletal activity;other molecular function

286940

ENSMUSG00000025278

Flnb

E9QNV9; mmu:286940; Q80X90; Q8VHX4; Q8VHX7; Q99KY3

ISG15 antiviral mechanism

0.629546282386664

0.254729742039053

154624.23024854946

1865154.4144755967

7592568.170254476

3.5924567565672367

2.0252928818961267

Cont_P35527

Keratin, type I cytoskeletal 9 OS=Homo sapiens OX=9606 GN=KRT9 PE=1 SV=3

310.424

cell organization and biogenesis;other biological processes

cytosol;cytoskeleton

cytoskeletal activity

3857

ENSG00000171403

KRT9

hsa:3857; O00109; P35527; Q0IJ47; Q14665

Formation of the cornified envelope

0.964570089320365

0.769556732848094

2.9224080803851068E7

9.369998400542612E7

5.1433611479478456E7

1.680891153782928

-0.865337343617375

Cont_P04264

Keratin, type II cytoskeletal 1 OS=Homo sapiens OX=9606 GN=KRT1 PE=1 SV=6

306.58

cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes

non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component

bone, tooth or skin structural activity;other molecular function

3848

ENSG00000167768

KRT1

B2RA01; hsa:3848; P04264; P85925; P86104; Q14720; Q6GSJ0; Q9H298

Corticotropin-releasing hormone signaling

Formation of the cornified envelope; Neutrophil degranulation; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin

0.89629386854896

0.631165145316661

1.5397854514739665E8

4.476405570139613E8

1.7631437693719265E8

1.5396114082700514

-1.344190633959504

P06909

Complement factor H [OS=Mus musculus]

292.01

cell adhesion;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes

non-structural extracellular;plasma membrane;other membranes;mitochondrion;other cell component

other molecular function

12628

ENSMUSG00000026365

Cfh

mmu:12628; P06909; Q6NZK3

Regulation of Complement cascade

0.329485122608543

1.50457038391225E-17

59542.32714759521

8439848.284125684

2.9357524779450033E7

7.147157645999157

1.7984413651895645

P16546

Spectrin alpha chain, non-erythrocytic 1 [OS=Mus musculus]

291.854

cell organization and biogenesis

plasma membrane;other membranes;cytosol;cytoskeleton;other cell component

cytoskeletal activity;other molecular function

20740

ENSMUSG00000057738

Sptan1

A3KGU6; A3KGU8; P16546; Q8K380; Q9CT05

FAS pathway and stress induction of HSP regulation

0.890289034593217

0.611910908670005

684626.7741473566

2263434.85725903

8138355.29233573

1.7251241667450168

1.8462234791150272

Cont_P13645

Keratin, type I cytoskeletal 10 OS=Homo sapiens OX=9606 GN=KRT10 PE=1 SV=6

286.713

cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes

plasma membrane;cytosol;cytoskeleton;other cell component

bone, tooth or skin structural activity;other molecular function

3858

ENSG00000186395

KRT10

hsa:3858; P13645; Q14664; Q8N175

Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin

0.941696908693733

0.561934876627864

1.1091978559495355E8

3.19749190691826E8

1.0914077913761683E8

1.5274239747458165

-1.5507504595301775

Cont_P35908

Keratin, type II cytoskeletal 2 epidermal OS=Homo sapiens OX=9606 GN=KRT2 PE=1 SV=2

284.975

cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes

plasma membrane;cytosol;cytoskeleton;other cell component

bone, tooth or skin structural activity;cytoskeletal activity

3849

ENSG00000172867

KRT2

hsa:3849; P35908; Q4VAQ2

Formation of the cornified envelope

0.933570718645937

0.544106843431104

4.776750778997586E7

7.640800383787991E7

3.617272663897294E7

0.6776941623987653

-1.0788214203552526

Q62059

Versican core protein [OS=Mus musculus]

279.715

cell adhesion;developmental processes

non-structural extracellular;extracellular matrix;other cell component

other molecular function

Vcan

Q62058; Q62059; Q9CUU0

1.70336894001643E-17

1.50457038391225E-17

104188.56292801573

5.89459061512507E7

9.510262638582683E7

9.144050892318086

0.6900935634294152

P10493

Nidogen-1 [OS=Mus musculus]

275.191

cell adhesion;cell organization and biogenesis;developmental processes;other biological processes

non-structural extracellular;extracellular matrix;other cell component

other molecular function

18073

ENSMUSG00000005397

Nid1

mmu:18073; P10493; Q3TKX9; Q8BQI3; Q8C3U8; Q8C9P6

Laminin interactions; Degradation of the extracellular matrix

0.461941385639594

0.251140212279038

322455.2944414853

9146738.193898173

3.1971627034095198E7

4.826086294877998

1.8054629019791015

O88207

Collagen alpha-1(V) chain [OS=Mus musculus]

275.025

cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes

extracellular matrix;other cell component

extracellular structural activity;other molecular function

12831

ENSMUSG00000026837

Col5a1

A3KGE3; mmu:12831; O88207; Q3UG94; Q6F6B0

Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion

0.311207075116757

0.268653947705267

80388.83753211687

1386447.3981625708

3098568.0509616495

4.108253882786396

1.1602087716820024

P37889

Fibulin-2 [OS=Mus musculus]

269.894

other biological processes

non-structural extracellular

other molecular function

14115

ENSMUSG00000064080

Fbln2

G5E8B3; mmu:14115; P37889; Q9WUI2

Molecules associated with elastic fibres

0.255240026777032

0.201227492083465

362692.0010392267

3.00676966042863E7

4.93487108032657E7

6.373325613535649

0.7147980442653664

Q8VHX6

Filamin-C [OS=Mus musculus]

249.498

cell organization and biogenesis;other biological processes

plasma membrane;other membranes;cytosol;cytoskeleton;other cell component

cytoskeletal activity

68794

ENSMUSG00000068699

Flnc

B2RY80; B9EKT2; mmu:68794; Q6PAI6; Q8VHX6; Q9JJ38

Cell-extracellular matrix interactions

0.57290809187594

0.962331548063155

406087.97266412666

1136666.5742976035

4459384.47065665

1.4849449173931863

1.9720354672374187

Q04857

Collagen alpha-1(VI) chain [OS=Mus musculus]

248.981

non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component

other molecular function

12833

ENSMUSG00000001119

Col6a1

mmu:12833; Q04857

0.971216996811237

0.962331548063155

76865.2077476112

1.4473176745930666E7

1.9886194591010433E7

7.556835176514044

0.45838561282899787

Cont_Q2UVX4

Complement C3 OS=Bos taurus OX=9913 GN=C3 PE=1 SV=2

247.154

cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes

non-structural extracellular;other cell component

signal transduction activity or receptor binding;enzyme regulator activity

280677

ENSBTAG00000017280

bta:280677; Q2KIZ4; Q2UVX4

Complement and coagulation cascades; Complement activation, classical pathway

0.506364847510615

0.573945385766997

1.4686759191254234E7

1.196234797265725E7

1.6127794015790733E7

-0.2960154932546844

0.43104852809057914

Q62261

Spectrin beta chain, non-erythrocytic 1 [OS=Mus musculus]

244.684

cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes

plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component

cytoskeletal activity;other molecular function

20742

ENSMUSG00000020315

Sptbn1

A2AFU1; mmu:20742; Q3TEM7; Q5SQL8; Q5SQL9; Q62261; Q9QWJ7

COPI-mediated anterograde transport; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; RHOU GTPase cycle; Interaction between L1 and Ankyrins; RHOV GTPase cycle

0.831411077141515

0.693719649766064

492454.03878621367

2299979.2063157237

6417771.720584608

2.223559830255895

1.4804516559416234

Q640N1

Adipocyte enhancer-binding protein 1 [OS=Mus musculus]

239.707

protein metabolism;other biological processes

nucleus;other cell component

nucleic acid binding activity;other molecular function

11568

ENSMUSG00000020473

Aebp1

mmu:11568; O88442; Q3TVV5; Q3TWA7; Q3TX56; Q3TXB2; Q5NCI9; Q61281; Q640N1

0.631359014803774

0.605387748357992

4843934.666021533

1.8648394999714002E7

3.1901344171106894E7

1.944800156743329

0.7745657453366123

P57780

Alpha-actinin-4 [OS=Mus musculus]

239.42

cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes

cytoskeleton;nucleus;other cell component

cytoskeletal activity;other molecular function

60595

ENSMUSG00000054808

Actn4

mmu:60595; P57780

Primary focal segmental glomerulosclerosis (FSGS)

Platelet degranulation

0.19149089837131

1.50457038391225E-17

20900.169415734228

4440337.50144963

1.1658414413951913E7

7.73101089020448

1.3926303478854152

Q7TPR4

Alpha-actinin-1 [OS=Mus musculus]

235.529

cell adhesion;cell organization and biogenesis;other biological processes

plasma membrane;other membranes;cytoskeleton;other cell component

signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function

109711

ENSMUSG00000015143

Actn1

mmu:109711; Q7TPR4

Regulation of actin cytoskeleton; Integrin-mediated cell adhesion; Focal adhesion

Platelet degranulation ; RHOF GTPase cycle; RHOBTB2 GTPase cycle; RHOD GTPase cycle; Regulation of cytoskeletal remodeling and cell spreading by IPP complex components

0.941696908693733

0.819280225722906

486802.1989182571

3717490.65968503

9946958.94260729

2.9329215275350284

1.419926404270893

P02468

Laminin subunit gamma-1 [OS=Mus musculus]

230.882

cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes

non-structural extracellular;extracellular matrix;other cell component

extracellular structural activity;other molecular function

Lamc1

P02468

0.675951294045723

0.459134305737471

18104.5719498812

3246292.9185144133

7951596.802164167

7.486295305072058

1.292451422124767

Q91ZX7

Prolow-density lipoprotein receptor-related protein 1 [OS=Mus musculus]

230.497

other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes

plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component

signal transduction activity or receptor binding;other molecular function

16971

Lrp1

mmu:16971; Q61291; Q91ZX7; Q920Y4

Statin pathway; Wnt signaling pathway

Scavenging of heme from plasma; Retinoid metabolism and transport

0.150830220548111

0.133639440745791

30670.78727387535

2243610.9879279765

5724840.5342227295

6.192813544488277

1.351412953764416

Cont_P60712

Actin, cytoplasmic 1 OS=Bos taurus OX=9913 GN=ACTB PE=1 SV=1

225.45

cell organization and biogenesis;stress response;developmental processes;other biological processes

plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component

enzyme regulator activity;cytoskeletal activity;other molecular function

100033878; 100135470; 100173832; 101844587; 102139853; 11461; 118833809; 280979; 396526; 403580; 414396; 443052; 450133; 60; 81822

Actb; ACTB

1.70336894001643E-17

1.50457038391225E-17

1996659.4544256767

5.335770948168167E7

1.0984219759318356E8

4.74003654023996

1.0416637530965958

P63260

Actin, cytoplasmic 2 [OS=Mus musculus]

217.791

cell organization and biogenesis;stress response;developmental processes;other biological processes

non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component

cytoskeletal activity;other molecular function

11465

ENSMUSG00000062825

Actg1

mmu:11465; P02571; P14104; P63260; P99022

Myometrial relaxation and contraction pathways; Regulation of actin cytoskeleton; Focal adhesion

1.70336894001643E-17

1.50457038391225E-17

126248.83655432604

256671.2110968777

1.0236513958265139

P33434

72 kDa type IV collagenase [OS=Mus musculus]

212.03

cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes

extracellular matrix;plasma membrane;other membranes;cytoskeleton;mitochondrion;nucleus;other cell component

other molecular function

17390

ENSMUSG00000031740

Mmp2

mmu:17390; P33434

Lung fibrosis; IL-3 signaling pathway; Matrix metalloproteinases

Collagen degradation; Extra-nuclear estrogen signaling; EPH-ephrin mediated repulsion of cells; Activation of Matrix Metalloproteinases

0.708142491896103

0.342075680986172

2.5908623508144036E7

5.359802560613743E7

8.73371018908004E7

1.0487474879918894

0.7044148019141078

P19096

Fatty acid synthase [OS=Mus musculus]

203.372

other metabolic processes;stress response;other biological processes

plasma membrane;other membranes;cytosol;ER/Golgi;other cell component

other molecular function

14104

ENSMUSG00000025153

Fasn

B1ATU8; mmu:14104; P19096; Q6PB72; Q8C4Z0; Q9EQR0

Fatty acyl-CoA biosynthesis; Vitamin B5 (pantothenate) metabolism

0.605074788683686

0.951921622352553

102793.32580216101

892753.3234074336

2995475.6339221266

3.1185150036599216

1.7464515936644316

Cont_Q3SZ57

Alpha-fetoprotein OS=Bos taurus OX=9913 GN=AFP PE=2 SV=1

202.89

other metabolic processes;developmental processes;other biological processes

non-structural extracellular;other cell component

other molecular function

506011

ENSBTAG00000017131

AFP

bta:506011; Q3SZ57

Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation

0.553772240900005

0.605387748357992

3.8603879197485335E7

3.679174310656657E7

4.2915740009991035E7

-0.06936379778833635

0.22212484601395752

P48678

Prelamin-A/C [OS=Mus musculus]

202.607

cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes

other membranes;cytoskeleton;nucleus;other cell component

other molecular function

16905

ENSMUSG00000028063

Lmna

B3RH23; B3RH24; mmu:16905; P11516; P48678; P97859; Q3TIH0; Q3TTS8; Q3U733; Q3U7I5; Q3UCA0; Q3UCJ8; Q3UCU3; Q91WF2; Q9DC21

Adipogenesis genes; FAS pathway and stress induction of HSP regulation

1.70336894001643E-17

0.139423967594304

75722.11050192213

6289356.16248022

5.369543399964929E7

6.37605390470787

3.0938151716360243

Q02788

Collagen alpha-2(VI) chain [OS=Mus musculus]

202.37

cell adhesion;signal transduction;other biological processes

non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component

other molecular function

12834

ENSMUSG00000020241

Col6a2

mmu:12834; Q02788; Q05505; Q8C972; Q8K229

Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion

0.767312384697355

0.633123216104285

121237.29953889274

1.173163988850227E7

2.0595787144729633E7

6.59642725930643

0.8119445729458827

P97927

Laminin subunit alpha-4 [OS=Mus musculus]

199.33

cell adhesion;developmental processes;other biological processes

non-structural extracellular;extracellular matrix;other cell component

signal transduction activity or receptor binding

16775

ENSMUSG00000019846

Lama4

mmu:16775; O88785; P70409; P97927; Q14BF2

Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion

Formation of the dystrophin-glycoprotein complex (DGC); Laminin interactions; MET activates PTK2 signaling

0.825047045401531

0.952104483873957

390078.69973194966

3065544.409694903

5760601.1965567535

2.9743061775357336

0.9100760795197015

P20152

Vimentin [OS=Mus musculus]

183.446

cell organization and biogenesis;stress response;developmental processes;other biological processes

plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component

cytoskeletal activity;nucleic acid binding activity;other molecular function

22352

ENSMUSG00000026728

Vim

mmu:22352; O08704; P20152; Q8CCH1

Spinal cord injury; Primary focal segmental glomerulosclerosis (FSGS); Alpha 6 beta 4 integrin signaling pathway

Aggrephagy; Striated Muscle Contraction; Caspase-mediated cleavage of cytoskeletal proteins; RHOBTB1 GTPase cycle

0.137621774180062

1.50457038391225E-17

1112472.104030337

1.292797841903164E7

7.464184195594883E7

3.5386556297624625

2.529487893505153

Q64727

Vinculin [OS=Mus musculus]

182.753

cell adhesion;cell organization and biogenesis;developmental processes;other biological processes

plasma membrane;other membranes;cytoskeleton;other cell component

cytoskeletal activity;other molecular function

22330

ENSMUSG00000021823

Vcl

mmu:22330; Q64727; Q8BP32; Q8BS46; Q922C5; Q922D9

Primary focal segmental glomerulosclerosis (FSGS); IL-3 signaling pathway; Regulation of actin cytoskeleton; Integrin-mediated cell adhesion; Focal adhesion

0.504745711776551

0.238791978742132

126150.06188907423

2359150.5810886133

6758257.200309387

4.225054687393182

1.5183837498676935

Q8K4G1

Latent-transforming growth factor beta-binding protein 4 [OS=Mus musculus]

180.216

cell-cell signaling;cell organization and biogenesis;transport;signal transduction

non-structural extracellular;extracellular matrix

other molecular function

108075

ENSMUSG00000040488

Ltbp4

E9QPD9; mmu:108075; Q8K4G0; Q8K4G1

TGF-beta receptor signaling activates SMADs; Molecules associated with elastic fibres

0.170566190602959

1.50457038391225E-17

50068.58855747415

2657641.7444799202

7291299.088613093

5.730097043103805

1.4560292425135843

Q68FD5

Clathrin heavy chain 1 [OS=Mus musculus]

180.117

cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes

plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component

nucleic acid binding activity;other molecular function

67300

ENSMUSG00000047126

Cltc

mmu:67300; Q68FD5

IL-7 signaling pathway; Kit receptor signaling pathway

0.413413145615294

1.50457038391225E-17

14581.209031729499

2078296.563295177

6830362.818457293

7.155147375878066

1.716560679478457

P02469

Laminin subunit beta-1 [OS=Mus musculus]

179.863

cell adhesion;cell organization and biogenesis;developmental processes;other biological processes

non-structural extracellular;extracellular matrix;nucleus;other cell component

signal transduction activity or receptor binding;extracellular structural activity;other molecular function

16777

ENSMUSG00000002900

Lamb1

E9PXZ9; P02469

Focal adhesion: PI3K-Akt-mTOR signaling pathway; Inflammatory response pathway; Alpha 6 beta 4 integrin signaling pathway; Focal adhesion

0.891178501081124

0.526489846375643

1.0460538665187027E7

2.1078383512013834E7

1.149610392953332E7

1.0108070867970473

-0.874619222314641

Q01853

Transitional endoplasmic reticulum ATPase [OS=Mus musculus]

179.055

cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;other biological processes

other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component

signal transduction activity or receptor binding;enzyme regulator activity;other molecular function

269523

ENSMUSG00000028452

Vcp

mmu:269523; Q01853; Q3TFH9; Q3TIM2; Q3TXN9; Q6PI18; Q8BSR6; Q8CEG4

IL-9 signaling pathway

0.953867932777128

0.808626104853287

621808.5300221853

4463650.11042755

1.2770955118061693E7

2.843681630952846

1.5165705767836266

Q03350

Thrombospondin-2 [OS=Mus musculus]

178.303

cell adhesion;other biological processes

non-structural extracellular;extracellular matrix;other cell component

other molecular function

21826

ENSMUSG00000023885

Thbs2

mmu:21826; Q03350; Q8CG21

Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion

Signaling by PDGF; O-glycosylation of TSR domain-containing proteins

0.535702081245677

0.49027994509233

1929828.2171104867

4211942.301314384

1.05864549049655E7

1.1260132409788162

1.3296619753283232

Q80YX1

Tenascin [OS=Mus musculus]

175.9

cell adhesion;cell-cell signaling;cell organization and biogenesis;stress response;developmental processes;other biological processes

non-structural extracellular;extracellular matrix;other cell component

signal transduction activity or receptor binding;other molecular function

21923

ENSMUSG00000028364

Tnc

mmu:21923; Q64706; Q80YX1; Q80YX2

Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion

0.474732236495646

0.560799429150649

20862.416559578665

96243.5238250637

211010.04547923067

2.205783186329275

1.132550311530058

Q61147

Ceruloplasmin [OS=Mus musculus]

175.43

cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes

non-structural extracellular

other molecular function

12870

ENSMUSG00000003617

mmu:12870; Q61147; Q6P5C8

0.470567140616547

0.232756100865398

116072.0240394514

1756646.5467629798

3587720.1567995367

3.9197317398446314

1.0302434268158966

Q3UQ28

Peroxidasin homolog [OS=Mus musculus]

173.636

cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes

extracellular matrix;ER/Golgi;other cell component

extracellular structural activity;other molecular function

69675

ENSMUSG00000020674

Pxdn

A4FU83; E9QNQ9; mmu:69675; Q3UQ28

Crosslinking of collagen fibrils

0.64860195920101

0.481687712882875

52188.79804577449

1748064.7562207088

5865453.59009746

5.06587464375226

1.7464840499849725

Q61316

Heat shock 70 kDa protein 4 [OS=Mus musculus]

169.044

protein metabolism;other metabolic processes

other cell component

other molecular function

Hspa4

Q61316

Regulation of HSF1-mediated heat shock response

0.760498481134506

0.704651587991194

51496.56273693644

1450318.0074060035

4790126.20554149

4.815749321311804

1.7236943963098632

Cont_P02533

Keratin, type I cytoskeletal 14 OS=Homo sapiens OX=9606 GN=KRT14 PE=1 SV=4

164.831

cell organization and biogenesis;other biological processes

plasma membrane;cytosol;cytoskeleton;nucleus;other cell component

cytoskeletal activity;other molecular function

3861

ENSG00000186847

KRT14

hsa:3861; P02533; Q14715; Q53XY3; Q9BUE3; Q9UBN2; Q9UBN3; Q9UCY4

Corticotropin-releasing hormone signaling

0.887279041944908

0.666244110962191

6829492.454091667

2.9333304518974166E7

9460012.597296894

2.1026893347000493

-1.6326255960338534

P11499

Heat shock protein HSP 90-beta [OS=Mus musculus]

164.719

cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes

non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component

enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function

15516

ENSMUSG00000023944

Hsp90ab1

mmu:15516; O89078; P11499; Q3UIQ7

Focal adhesion: PI3K-Akt-mTOR signaling pathway

1.70336894001643E-17

1.50457038391225E-17

166033.98771248801

1.1608041082716169E7

4.22825068683512E7

6.127502123927423

1.8649363840924498

Q9JKF1

Ras GTPase-activating-like protein IQGAP1 [OS=Mus musculus]

163.926

cell organization and biogenesis;developmental processes;signal transduction;other biological processes

plasma membrane;other membranes;cytoskeleton;nucleus;other cell component

enzyme regulator activity;other molecular function

29875

ENSMUSG00000030536

Iqgap1

G3UW45; mmu:29875; Q9JKF1

G13 signaling pathway; Regulation of actin cytoskeleton

0.991639536226218

0.787568130909409

58984.367745696

944145.2185002686

3795509.9873349466

4.000604214958747

2.007213065802415

P52480

Pyruvate kinase PKM [OS=Mus musculus]

163.393

cell organization and biogenesis;other metabolic processes;other biological processes

cytosol;ER/Golgi;nucleus;other cell component

nucleic acid binding activity;kinase activity;other molecular function

18746

ENSMUSG00000032294

Pkm

mmu:18746; P52480; Q3TBV8; Q3TBW5; Q3TC59; Q3U1X3; Q3U5P6; Q4VC20; Q64484; Q91YI8; Q9CWB1

Glycolysis and gluconeogenesis; Purine metabolism

Neutrophil degranulation; Pyruvate metabolism; Glycolysis; Regulation of pyruvate metabolism

1.70336894001643E-17

1.50457038391225E-17

224031.9482756436

1.3595916090065738E7

3.1698865102110166E7

5.923325069145465

1.2212578260965212

P63017

Heat shock cognate 71 kDa protein [OS=Mus musculus]

161.557

non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component

signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function

15481

ENSMUSG00000015656

Hspa8

mmu:15481; P08109; P12225; P63017; Q3U6R0; Q3U764; Q3U7D7; Q3U7E2; Q3U9B4; Q3U9G0; Q3UGM0; Q5FWJ6; Q62373; Q62374; Q62375; Q6NZD0

Mapk signaling pathway; Exercise-induced circadian regulation

1.70336894001643E-17

1.50457038391225E-17

232221.67704249235

1.2001189016638666E7

3.440867978172333E7

5.6915308887768115

1.5195951909349734

Q9JHU4

Cytoplasmic dynein 1 heavy chain 1 [OS=Mus musculus]

161.009

cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes

cytoskeleton;other cell component

cytoskeletal activity;other molecular function

13424

ENSMUSG00000018707

Dync1h1

E9QM71; mmu:13424; Q9JHU4

0.936818656936794

0.758743075163871

294620.0253220563

1462326.6297541

5162177.518126

2.3113381932709602

1.819714161940933

Q99K41

EMILIN-1 [OS=Mus musculus]

157.011

cell adhesion;cell organization and biogenesis;developmental processes;other biological processes

non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component

signal transduction activity or receptor binding;extracellular structural activity;other molecular function

100952

ENSMUSG00000029163

Emilin1

mmu:100952; Q99K41

Molecules associated with elastic fibres

1.70336894001643E-17

1.50457038391225E-17

384416.66366236034

2364922.89508055

2.6210503669211938

Q61879

Myosin-10 [OS=Mus musculus]

146

cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes

plasma membrane;other membranes;cytosol;cytoskeleton;other cell component

cytoskeletal activity;nucleic acid binding activity;other molecular function

77579

ENSMUSG00000020900

Myh10

mmu:77579; Q5SV63; Q61879

Regulation of actin cytoskeleton

RHO GTPases activate PAKs

0.933545599871938

0.676239752697828

123378.89612673952

562909.3462758837

1089526.38375758

2.1898069585990854

0.9527266255660732

Cont_P00761

Trypsin OS=Sus scrofa OX=9823 PE=1 SV=1

143.502

protein metabolism;other biological processes

non-structural extracellular

other molecular function

0.34040294575649

0.357784551188889

5.863252009900073E9

4.479417756781787E9

2.35988129070601E9

-0.38838984667240734

-0.9245969308204053

P20029

Endoplasmic reticulum chaperone BiP [OS=Mus musculus]

142.966

protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes

non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component

enzyme regulator activity;translation activity;other molecular function

14828

ENSMUSG00000026864

Hspa5

mmu:14828; O35642; P20029; Q3UFF2; Q61630

Mapk signaling pathway

Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Regulation of HSF1-mediated heat shock response

1.70336894001643E-17

1.50457038391225E-17

8403011.594768586

1.57890948929286E7

0.9099500914019807

Cont_P13647

Keratin, type II cytoskeletal 5 OS=Homo sapiens OX=9606 GN=KRT5 PE=1 SV=3

142.395

cell organization and biogenesis;other biological processes

cytosol;cytoskeleton;other cell component

bone, tooth or skin structural activity;cytoskeletal activity;other molecular function

3852

ENSG00000186081

KRT5

hsa:3852; P13647; Q6PI71; Q6UBJ0; Q8TA91

0.746833150482801

0.707170943024881

5615099.536380176

2.8752414910160065E7

1.3998817771053001E7

2.356299630862457

-1.0383781390912068

Cont_P08779

Keratin, type I cytoskeletal 16 OS=Homo sapiens OX=9606 GN=KRT16 PE=1 SV=4

140.751

cell organization and biogenesis;stress response;other biological processes

plasma membrane;cytosol;cytoskeleton

cytoskeletal activity

3868

ENSG00000186832

KRT16

A8K488; hsa:3868; P08779; P30654; Q16402; Q9UBG8

Vitamin D receptor pathway

Formation of the cornified envelope

0.887279041944908

0.761460393544015

1275668.1444026066

5401589.786976026

2569640.8216647534

2.082131009886816

-1.0718173643929836

Cont_P02465

Collagen alpha-2(I) chain OS=Bos taurus OX=9913 GN=COL1A2 PE=1 SV=2

139.99

non-structural extracellular;extracellular matrix

extracellular structural activity;other molecular function

282188

ENSBTAG00000013472

COL1A2

A6QP13; bta:282188; O62649; P02465

Inflammatory response pathway; Focal adhesion

0.488872343346086

0.421836754550416

70110.45197339094

48702.045776696206

54970.44581499727

-0.5256471599506324

0.1746738044170317

Cont_P12763

Alpha-2-HS-glycoprotein OS=Bos taurus OX=9913 GN=AHSG PE=1 SV=2

132.772

stress response;other biological processes

non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component

enzyme regulator activity

280988

AHSG

A6QLF7; bta:280988; P12763

0.36488675645736

0.624272910267193

6.882384659684638E8

4.440672611032756E8

7.064361313920757E8

-0.632130314815548

0.6697809205631783

P07901

Heat shock protein HSP 90-alpha [OS=Mus musculus]

132.382

cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes

plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component

signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function

15519

ENSMUSG00000021270

Hsp90aa1

mmu:15519; P07901

EBV LMP1 signaling; Focal adhesion: PI3K-Akt-mTOR signaling pathway; IL-6 signaling pathway; IL-2 signaling pathway

0.251664970734015

1.50457038391225E-17

138049.65358917884

1606774.576019598

6014683.841021903

3.5409083660663305

1.9043213658945874

Q02819

Nucleobindin-1 [OS=Mus musculus]

131.152

signal transduction

non-structural extracellular;other membranes;ER/Golgi

enzyme regulator activity;nucleic acid binding activity;other molecular function

18220

ENSMUSG00000030824

Nucb1

mmu:18220; Q02819; Q3TU42; Q9CWA1; Q9D8J4; Q9DBL3

Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation

0.130903496983571

1.50457038391225E-17

30635.69892492515

2379424.5332984333

6548209.148806977

6.279255122519686

1.460487703830008

Q91V92

ATP-citrate synthase [OS=Mus musculus]

129.973

other metabolic processes

cytosol

other molecular function

104112

ENSMUSG00000020917

Acly

mmu:104112; Q91V92

Fatty acid biosynthesis

Neutrophil degranulation; Fatty acyl-CoA biosynthesis

0.509570119936397

0.437429424171984

27537.414327710998

644183.8162072281

1777761.9344937534

4.548007409788159

1.464517819878004

A2ASQ1

Agrin [OS=Mus musculus]

128.989

cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes

non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cell component

signal transduction activity or receptor binding;other molecular function

11603

ENSMUSG00000041936

Agrn

A2ASP9; A2ASQ0; A2ASQ1; B2RWU1

Primary focal segmental glomerulosclerosis (FSGS)

1.70336894001643E-17

1.50457038391225E-17

1028829.4241236168

2045725.4701757336

0.9916087441172836

Q61508

Extracellular matrix protein 1 [OS=Mus musculus]

127.379

stress response;developmental processes;signal transduction;other biological processes

non-structural extracellular

signal transduction activity or receptor binding;other molecular function

13601

ENSMUSG00000028108

Ecm1

mmu:13601; Q3U5Q5; Q61508

Platelet degranulation

0.121600547823456

1.50457038391225E-17

74811.39241511819

3515293.344106073

1.1331897286900917E7

5.554243291002194

1.6886724407889737

Cont_P04259

Keratin, type II cytoskeletal 6B OS=Homo sapiens OX=9606 GN=KRT6B PE=1 SV=5

126.901

cell organization and biogenesis;other biological processes

cytosol;cytoskeleton

bone, tooth or skin structural activity;cytoskeletal activity

3854

ENSG00000185479

KRT6B

hsa:3854; P04259; P48669

Formation of the cornified envelope

0.801271130817871

0.758743075163871

298970.1410949

1115770.6869766254

854901.7358096777

1.8999672440407571

-0.3842100469035007

P17182

Alpha-enolase [OS=Mus musculus]

126.804

other metabolic processes;developmental processes;other biological processes

plasma membrane;other membranes;cytosol;other cell component

nucleic acid binding activity;other molecular function

13806; 433182

ENSMUSG00000059040; ENSMUSG00000063524

Eno1

mmu:13806; mmu:433182; P17182; Q99KT7; Q9DCY7

Glycolysis and gluconeogenesis

1.70336894001643E-17

1.50457038391225E-17

47358.53377381337

1.3905788568310633E7

2.89416009584274E7

8.19784542826019

1.0574591701978524

P08113

Endoplasmin [OS=Mus musculus]

126.346

cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes

non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cell component

signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function

22027

ENSMUSG00000020048

Hsp90b1

mmu:22027; P08113; P11427

Focal adhesion: PI3K-Akt-mTOR signaling pathway; Hypoxia-dependent self-renewal of myoblasts

0.205304099107124

1.50457038391225E-17

52582.03853978356

6037105.20140975

1.2434595462188734E7

6.84314305674472

1.0424307261560617

P58252

Elongation factor 2 [OS=Mus musculus]

126.048

cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes

plasma membrane;other membranes;cytosol;translational apparatus;other cell component

cytoskeletal activity;translation activity;nucleic acid binding activity;other molecular function

13629

ENSMUSG00000034994

Eef2

mmu:13629; P58252; Q544E4

Translation factors

Neutrophil degranulation; Protein methylation; Peptide chain elongation; Synthesis of diphthamide-EEF2

0.84258396038376

0.471929633209224

229633.38558146535

4859646.5618234025

1.3065706600835832E7

4.40344708092177

1.426861851823294

Cont_P02538

Keratin, type II cytoskeletal 6A OS=Homo sapiens OX=9606 GN=KRT6A PE=1 SV=3

123.757

cell organization and biogenesis;stress response;other biological processes

cytosol;cytoskeleton

bone, tooth or skin structural activity;cytoskeletal activity

3853

ENSG00000205420

KRT6A

A4QPC1; hsa:3853; P02538; P48667; Q08AR4; Q6NT67; Q96CL4

Ectoderm differentiation; Ectoderm differentiation; Pancreatic cancer subtypes

Formation of the cornified envelope

0.84258396038376

0.745886066139481

2182876.549653717

8485501.699692694

3982846.61307857

1.9587694181864725

-1.0912000408128149

P97298

Pigment epithelium-derived factor [OS=Mus musculus]

123.502

cell cycle OR cell proliferation;developmental processes;other biological processes

non-structural extracellular;extracellular matrix;other cell component

enzyme regulator activity

20317

ENSMUSG00000000753

Serpinf1

mmu:20317; O70629; O88691; P97298

0.770205086382264

0.434748506750565

462579.17347644636

5921015.69252881

1.5757205380580032E7

3.6780724587081086

1.4120951058109443

Q70E20

Sushi, nidogen and EGF-like domain-containing protein 1 [OS=Mus musculus]

122.942

cell adhesion

non-structural extracellular;extracellular matrix

other molecular function

208777

Sned1

A6H6I3; mmu:208777; Q70E20; Q810H2; Q8BMD9

1.70336894001643E-17

1.50457038391225E-17

37861.533059704365

4995161.517920501

1.4223395042125002E7

7.0436546892015075

1.5096626357764027

P13020

Gelsolin [OS=Mus musculus]

122.934

cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes

non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component

cytoskeletal activity;other molecular function

227753

ENSMUSG00000026879

Gsn

mmu:227753; P13020; Q3UPB1; Q8R590

Regulation of actin cytoskeleton

Neutrophil degranulation; Caspase-mediated cleavage of cytoskeletal proteins

0.379422692457324

0.186266168629733

1139775.9088509877

1.1033925013460701E7

2.9144067496602204E7

3.2751239717088607

1.4012561603631017

Q61398

Procollagen C-endopeptidase enhancer 1 [OS=Mus musculus]

120.4

protein metabolism;other biological processes

enzyme regulator activity;other molecular function

18542

ENSMUSG00000029718

Pcolce

mmu:18542; O35113; Q61398

mRNA processing

Collagen biosynthesis and modifying enzymes; Crosslinking of collagen fibrils

0.288320039261486

0.151224536345852

84503.2651712337

7672570.19904635

1.2538308810459368E7

6.504559042639965

0.7085609223825361

P26039

Talin-1 [OS=Mus musculus]

118.226

cell adhesion;cell organization and biogenesis;signal transduction

plasma membrane;other membranes;cytosol;cytoskeleton;other cell component

signal transduction activity or receptor binding;cytoskeletal activity;other molecular function

21894

ENSMUSG00000028465

Tln1

A2AIM8; mmu:21894; P26039; Q8VEF0

Primary focal segmental glomerulosclerosis (FSGS); Integrin-mediated cell adhesion; Focal adhesion

0.738983404380581

0.680632778351053

147890.2697082064

286851.2614141297

2291518.0404973766

0.9557757272954962

2.997928876406007

Q8BPB5

EGF-containing fibulin-like extracellular matrix protein 1 [OS=Mus musculus]

117.738

protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes

extracellular matrix

signal transduction activity or receptor binding;kinase activity;other molecular function

216616

ENSMUSG00000020467

Efemp1

mmu:216616; Q6Y3N6; Q8BPB5

0.376780684027729

1.50457038391225E-17

29995.485006469138

1370373.3251651835

3606517.1409647237

5.51367980488993

1.396037306430432

P09411

Phosphoglycerate kinase 1 [OS=Mus musculus]

116.462

protein metabolism;other metabolic processes;stress response;other biological processes

non-structural extracellular;other membranes;cytosol;mitochondrion;other cell component

kinase activity;other molecular function

18655

ENSMUSG00000062070

Pgk1

mmu:18655; P09411; Q3TPE6; Q3UKV8; Q5XJE7

Glycolysis and gluconeogenesis

Gluconeogenesis; Glycolysis

1.70336894001643E-17

1.50457038391225E-17

46750.53578358531

4500077.619792943

1.4795712145397767E7

6.588823176749667

1.7171573466629246

P27773

Protein disulfide-isomerase A3 [OS=Mus musculus]

115.891

cell adhesion;cell organization and biogenesis;stress response;signal transduction;other biological processes

non-structural extracellular;other membranes;ER/Golgi;other cell component

nucleic acid binding activity;other molecular function

14827

ENSMUSG00000027248

Pdia3

mmu:14827; P27773; Q3TEI9; Q3TIL2; Q3UZK8; Q8C2F4; Q99LF6

ER-Phagosome pathway; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Calnexin/calreticulin cycle

0.874168055361729

0.498293621965442

196243.61956605766

7238345.98431998

1.5315044241817234E7

5.204942414672023

1.0812175609972197

P10107

Annexin A1 [OS=Mus musculus]

115.566

cell organization and biogenesis;stress response;transport;signal transduction;other biological processes

non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component

enzyme regulator activity;other molecular function

16952

ENSMUSG00000024659

Anxa1

mmu:16952; P10107

Spinal cord injury; Prostaglandin synthesis and regulation

G alpha (q) signalling events; G alpha (i) signalling events; Formyl peptide receptors bind formyl peptides and many other ligands

1.70336894001643E-17

1.50457038391225E-17

8983.410658903753

4211649.667813237

1.08370832078509E7

8.872906434854283

1.3635191681000571

Cont_Q2KJF1

Alpha-1B-glycoprotein OS=Bos taurus OX=9913 GN=A1BG PE=1 SV=1

115.502

signal transduction

non-structural extracellular;plasma membrane;other membranes

518955

A1BG

bta:518955; Q2KJF1

Platelet degranulation ; Neutrophil degranulation

0.360991986803736

0.641514600397631

9385194.584847162

6762503.63408608

1.0317459698123023E7

-0.4728291927834855

0.6094584335875003

Cont_Q3MHN5

Vitamin D-binding protein OS=Bos taurus OX=9913 GN=GC PE=2 SV=1

113.599

other metabolic processes;transport

non-structural extracellular;other cell component

transporter activity;cytoskeletal activity;other molecular function

530076

bta:530076; Q3MHN5

0.479472599858427

0.579435037816218

1.2784681703575822E7

1.0785165311962552E7

1.4618596373270534E7

-0.24536795278737014

0.43875650549577433

P17742

Peptidyl-prolyl cis-trans isomerase A [OS=Mus musculus]

113.527

cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes

non-structural extracellular;cytosol;nucleus;other cell component

signal transduction activity or receptor binding;other molecular function

268373

ENSMUSG00000071866

Ppia

mmu:268373; P17742; Q9CWJ5; Q9R137

Neutrophil degranulation; Basigin interactions

1.70336894001643E-17

1.50457038391225E-17

5533917.143041036

1.0696784170781441E7

4.607074026803666E7

0.9508041886121662

2.1066736424755597

Q69ZN7

Myoferlin [OS=Mus musculus]

112.647

cell organization and biogenesis;other metabolic processes;stress response;other biological processes

plasma membrane;other membranes;nucleus

other molecular function

226101

ENSMUSG00000048612

Myof

mmu:226101; Q69ZN7; Q7TMG0; Q80V33; Q8BU64; Q8BU70; Q8BUC1; Q8BVY6; Q8C0D1; Q8R3B4

0.930955411749965

0.888974672311279

74563.786625436

1104935.9693987637

3065805.015040973

3.8893438309545054

1.4723031761891572

P26041

Moesin [OS=Mus musculus]

112.068

cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes

plasma membrane;other membranes;cytosol;cytoskeleton;other cell component

signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function

17698

ENSMUSG00000031207

Msn

B1AX70; mmu:17698; P26041; Q3UL28; Q8BSN4

Regulation of actin cytoskeleton

Recycling pathway of L1

0.157138696252226

1.50457038391225E-17

3564499.916018247

1.120013397828275E7

1.9030746620886367E7

1.6517443981180746

0.764816172839194

P05064

Fructose-bisphosphate aldolase A [OS=Mus musculus]

112.015

cell organization and biogenesis;other metabolic processes;other biological processes

plasma membrane;other membranes;cytosol;cytoskeleton;other cell component

other molecular function

11674

ENSMUSG00000030695

Aldoa

mmu:11674; P05064

Glycolysis and gluconeogenesis

Platelet degranulation ; Neutrophil degranulation; Gluconeogenesis; Glycolysis

0.0771819601934254

1.50457038391225E-17

21908.055682018665

4518789.603964283

1.0653934694757948E7

7.688331123815105

1.2373780513518877

B2RQC6

Multifunctional protein CAD [OS=Mus musculus]

111.853

other metabolic processes;stress response;transport;developmental processes;other biological processes

cytosol;nucleus;other cell component

kinase activity;other molecular function

69719

ENSMUSG00000013629

Cad

B2RQC6; B7ZN27; mmu:69719

Mechanisms associated with pluripotency

Pyrimidine biosynthesis

0.963127218853016

0.666244110962191

34439.61575478624

139659.55402474166

452794.3373622177

2.019773319192686

1.6969416450846668

Q8BND5

Sulfhydryl oxidase 1 [OS=Mus musculus]

111.186

cell organization and biogenesis;other biological processes

non-structural extracellular;other membranes;ER/Golgi

other molecular function

104009

ENSMUSG00000033684

Qsox1

mmu:104009; Q3TDY9; Q3TE19; Q3TR29; Q3UEL4; Q8BND5; Q8K041; Q9DBL6

0.162753188077458

1.50457038391225E-17

25068.200750320597

1818282.5759143168

5040172.36278756

6.180574161657264

1.4708966480504568

100

Accession	Description	Sum PEP Score	Biological Process	Cellular Component	Molecular Function	Entrez Gene ID	Ensembl Gene ID	Gene Symbol	Gene ID	WikiPathways	Reactome Pathways	Abundance Ratio Adj. P-Value: (SQ_16h) / (LQ_16h)	Abundance Ratio Adj. P-Value: (SQ_6h) / (LQ_6h)	LQ6h_AVERAGE	LQ16h_AVERAGE	LQ24h_AVERAGE	SQ6h_AVERAGE	SQ16h_AVERAGE	FC_SQ_16_vs_LQ_16h	FC_SQ_6_vs_LQ_6h
P11276	Fibronectin [OS=Mus musculus]	867.353	cell adhesion;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes	non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi	signal transduction activity or receptor binding;enzyme regulator activity;other molecular function	14268	ENSMUSG00000026193	Fn1	G5E8B8; mmu:14268; P11276; Q61567; Q61568; Q61569; Q64233; Q80UI4	Focal adhesion: PI3K-Akt-mTOR signaling pathway; Inflammatory response pathway; Regulation of actin cytoskeleton; Comprehensive IL-17A signaling; Focal adhesion	ECM proteoglycans; Platelet degranulation ; Cell surface interactions at the vascular wall; Syndecan interactions; MAP2K and MAPK activation; Integrin cell surface interactions; Molecules associated with elastic fibres; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Fibronectin matrix formation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; Degradation of the extracellular matrix; Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells; MET activates PTK2 signaling; GPER1 signaling	0.974036928885484	0.435823028559966	2.022341523870097E8	2.12696235413058E8	2.684744239015217E8	1.2629719382404166E8	2.7495824150743634E8	0.37041803136358886	-0.6792040691298411
P11087	Collagen alpha-1(I) chain [OS=Mus musculus]	797.017	cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes	non-structural extracellular;extracellular matrix;other cell component	extracellular structural activity;other molecular function	12842	ENSMUSG00000001506	Col1a1	mmu:12842; P11087; Q53WT0; Q60635; Q61367; Q61427; Q63919; Q6PCL3; Q810J9	Osteoblast signaling; Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Comprehensive IL-17A signaling; Focal adhesion	Cell surface interactions at the vascular wall; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ECM proteoglycans; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; GPVI-mediated activation cascade; GP1b-IX-V activation signalling; Platelet Adhesion to exposed collagen; Platelet Aggregation (Plug Formation); MET activates PTK2 signaling	1.58880673198775E-4	0.0629214061377862	2.0798706453114033E8	5.92854376184685E8	5.928171930552336E8	5.973622733379293E7	8.428319253806247E7	-2.814360908962058	-1.799815773091645
Q01149	Collagen alpha-2(I) chain [OS=Mus musculus]	773.662	cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes	non-structural extracellular;extracellular matrix;other cell component	extracellular structural activity;other molecular function	12843	ENSMUSG00000029661	Col1a2	mmu:12843; Q01149; Q8CGA5	Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Focal adhesion	Crosslinking of collagen fibrils; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; ECM proteoglycans; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; GPVI-mediated activation cascade; GP1b-IX-V activation signalling; Platelet Adhesion to exposed collagen; Platelet Aggregation (Plug Formation); MET activates PTK2 signaling	0.0150838661305169	0.0347692006632991	1.7308392932505235E8	3.475967473053053E8	4.108532345040607E8	4.271481968913147E7	9.036410240893161E7	-1.9435929082069783	-2.018663180583724
P08121	Collagen alpha-1(III) chain [OS=Mus musculus]	695.631	cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes	extracellular matrix;other cell component	signal transduction activity or receptor binding;extracellular structural activity;other molecular function	12825	ENSMUSG00000026043	Col3a1	mmu:12825; P08121; Q61429; Q9CRN7	Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Focal adhesion	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ECM proteoglycans; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; MET activates PTK2 signaling	0.00738207855214502	0.394949139624895	6.282890624937943E7	2.8394661715058166E8	2.9634851273536664E8	3.0365458724261332E7	6.6157215803336866E7	-2.101649298329015	-1.0489973014656733
Q9QXS1	Plectin [OS=Mus musculus]	659.702	cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes	plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component	cytoskeletal activity;other molecular function	18810	ENSMUSG00000022565	Plec	E9QN87; mmu:18810; Q6S384; Q6S389; Q6S394; Q9CS65; Q9QUT2; Q9QXQ8; Q9QXQ9; Q9QXR0; Q9QXR1; Q9QXR2; Q9QXR3; Q9QXR4; Q9QXR5; Q9QXR6; Q9QXR7; Q9QXR8; Q9QXR9; Q9QXS0; Q9QXS1; Q9QXS2; Q9QXS3	Alpha 6 beta 4 integrin signaling pathway; EGFR1 signaling pathway	Type I hemidesmosome assembly; Caspase-mediated cleavage of cytoskeletal proteins	0.850917681937748	0.702330308974487	4599273.114185064	1.6676006673579365E7	4.0231485359460294E7	1.01501282886872E7	4.28490141732006E7	1.3614881580387048	1.1420201863832355
P08122	Collagen alpha-2(IV) chain [OS=Mus musculus]	526.992	RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes	non-structural extracellular;extracellular matrix	extracellular structural activity	12827	ENSMUSG00000031503	Col4a2	mmu:12827; P08122; Q3B7C2; Q3TPV9; Q61375; Q66JS5; Q6RCT6; Q6RCT7; Q6U9X1; Q8BPI9; Q8BPK3; Q91VI3	Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Focal adhesion	Laminin interactions; Signaling by PDGF; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions	0.979628232635575	0.959159975702413	1.3981747232493034E7	5.0194805286054574E7	9.68446240720073E7	1.701609057115766E7	5.972856146483746E7	0.25088290969327387	0.2833549587108298
Q3U962	Collagen alpha-2(V) chain [OS=Mus musculus]	518.514	cell organization and biogenesis;developmental processes;other biological processes	extracellular matrix;other cell component	extracellular structural activity;other molecular function	12832	ENSMUSG00000026042	Col5a2	mmu:12832; Q3TVR2; Q3U962; Q3UHK7; Q3UTT4; Q3V1J6; Q61431; Q7TMS0; Q80VS8	Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion	Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions	0.0769666553885184	0.453486790198347	1.5753424919239333E7	4.592471970087584E7	6.332560400994137E7	1.0471363011153279E7	2.1079551940947264E7	-1.1234267140336414	-0.5892162722872147
Q05793	Basement membrane-specific heparan sulfate proteoglycan core protein [OS=Mus musculus]	507.28	cell organization and biogenesis;transport;developmental processes;other biological processes	non-structural extracellular;extracellular matrix;ER/Golgi	other molecular function	15530		Hspg2	mmu:15530; Q05793			0.208890689478245	0.285967432697218	2.1355561683383033E7	4.109385814368304E7	4.603208822128189E7	8244737.341084313	1.8998181152407136E7	-1.1130614814811859	-1.373066405061947
Q61554	Fibrillin-1 [OS=Mus musculus]	499.202	cell adhesion;other metabolic processes;developmental processes;signal transduction;other biological processes	non-structural extracellular;extracellular matrix	signal transduction activity or receptor binding;extracellular structural activity;other molecular function	14118	ENSMUSG00000027204	Fbn1	A2AQ53; mmu:14118; Q60826; Q61554	Comprehensive IL-17A signaling	Integrin cell surface interactions; Degradation of the extracellular matrix; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; TGF-beta receptor signaling activates SMADs; Molecules associated with elastic fibres	0.087482121441914	0.0455630470425967	2.17735814942991E7	5.216417896597137E7	4.48746709774994E7	5145074.9913376765	2.082557122129057E7	-1.3247033834999922	-2.0813147229720497
Q8BTM8	Filamin-A [OS=Mus musculus]	493.069	cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes	plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component	signal transduction activity or receptor binding;cytoskeletal activity;other molecular function	192176	ENSMUSG00000031328	Flna	B7FAV0; O54934; Q7TQI1; Q8BLK1; Q8BTM8; Q8BTN7; Q8VHX5; Q8VHX8; Q99KQ2	Mapk signaling pathway; Focal adhesion	Platelet degranulation ; Cell-extracellular matrix interactions; RHO GTPases activate PAKs; GP1b-IX-V activation signalling	0.946239447314336	0.904360680536565	4952287.405198824	1.1395384793048913E7	3.45895898091015E7	4296604.098486893	1.4686023116833666E7	0.36599413443703693	-0.20489819440782575
P02463	Collagen alpha-1(IV) chain [OS=Mus musculus]	487.707	cell organization and biogenesis;developmental processes;signal transduction;other biological processes	non-structural extracellular;extracellular matrix	extracellular structural activity;other molecular function	12826	ENSMUSG00000031502	Col4a1	mmu:12826; P02463; Q3UHJ4; Q3UJE7; Q3UQV2; Q53X35; Q6GQS7; Q6PHB5; Q99LQ8	Spinal cord injury; Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion	Laminin interactions; Signaling by PDGF; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions	0.483508479481234	0.777395712279767	4620515.057112186	2.1463797748519864E7	4.45598479783772E7	8911949.32392111	3.3156314746725336E7	0.627378297898211	0.9476873486816851
Q60847	Collagen alpha-1(XII) chain [OS=Mus musculus]	480.266	cell adhesion;developmental processes	other cell component		12816	ENSMUSG00000032332	Col12a1	mmu:12816; P70322; Q60847		Assembly of collagen fibrils and other multimeric structures; Collagen chain trimerization; Collagen degradation	0.119424004207039	0.0103905836841461	5.1736330625803865E7	2.9952489655588504E7	5.41828161343536E7	1.0537780206453351E7	1.4629541968462234E7	-1.033791323716814	-2.2956067413237813
Q8VDD5	Myosin-9 [OS=Mus musculus]	418.364	cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;stress response;transport;developmental processes;other biological processes	plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component	signal transduction activity or receptor binding;cytoskeletal activity;other molecular function	17886	ENSMUSG00000022443	Myh9	mmu:17886; Q3UHT9; Q3UHU4; Q6KAN6; Q811I2; Q8VDD5	Primary focal segmental glomerulosclerosis (FSGS)	RHO GTPases activate PAKs; Regulation of actin dynamics for phagocytic cup formation	0.87421335771164	0.91728043005175	5176534.940650649	8067345.413832072	1.95000780331961E7	7844465.70271172	1.9759662960152034E7	1.2923924059140754	0.5996884741558165
Cont_P02453	Collagen alpha-1(I) chain OS=Bos taurus OX=9913 GN=COL1A1 PE=1 SV=3	414.689	cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes	non-structural extracellular;extracellular matrix;other cell component	extracellular structural activity;other molecular function	282187	ENSBTAG00000013103	COL1A1	bta:282187; P02453; Q3MHM2	Inflammatory response pathway; Osteoblast signaling; Focal adhesion	Fibronectin matrix formation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Collagen degradation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; Collagen chain trimerization; GPVI-mediated activation cascade; Platelet Aggregation (Plug Formation); Platelet Adhesion to exposed collagen; GP1b-IX-V activation signalling	0.067749585016969	0.108042253370914	3262486.7198886867	3910059.36528234	2611857.205675677	1102058.9569362423	924822.5329095138	-2.079942057680374	-1.5657706231882562
Cont_P02769	Albumin OS=Bos taurus OX=9913 GN=ALB PE=1 SV=4	390.555	stress response;other biological processes	non-structural extracellular;other cell component	nucleic acid binding activity;other molecular function	280717		ALB	A5PJX3; bta:280717; O02787; P02769; P04277; Q3SZR2			0.946568086066385	0.846117085258013	2.9099571807541137E9	2.4034772237737E9	1.9319093626168566E9	2.38097622607819E9	2.6841204207378564E9	0.15932626621701673	-0.28944470896955565
P01027	Complement C3 [OS=Mus musculus]	388.541	cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes	non-structural extracellular;other cell component	signal transduction activity or receptor binding;enzyme regulator activity	12266	ENSMUSG00000024164	C3	mmu:12266; P01027; Q61370; Q80XP1	Complement activation, classical pathway; Tyrobp causal network in microglia; Comprehensive IL-17A signaling	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade; Neutrophil degranulation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; G alpha (i) signalling events; Peptide ligand-binding receptors; Alternative complement activation; Activation of C3 and C5	0.939492000987438	0.413470300505934	1.6657146132333001E7	4.4549110086954266E7	9.444511683907779E7	3.6733221642207734E7	8.026680998659676E7	0.8494069495035886	1.1409441863835255
Cont_Q7SIH1	Alpha-2-macroglobulin OS=Bos taurus OX=9913 GN=A2M PE=1 SV=2	370.864		non-structural extracellular	enzyme regulator activity;other molecular function	513856	ENSBTAG00000018137	A2M	A8E647; bta:513856; Q7SIH1	IL-6 signaling pathway		0.944154202827561	0.671798309985569	7.564994624258716E7	7.018676700369896E7	1.6376415758098435E8	5.23492843648457E7	8.250822323914327E7	0.23333886293366002	-0.5311692421661273
Cont_Q29443	Serotransferrin OS=Bos taurus OX=9913 GN=TF PE=2 SV=1	343.183	stress response;transport;other biological processes	non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle	other molecular function	280705		TF	bta:280705; Q0IIK2; Q29443			0.902231721267411	0.506704636011438	2.32106703986673E8	1.5606409762411097E8	1.0552713551758902E8	1.3567523181654152E8	1.6257112433260167E8	0.058932345527944796	-0.7746308192572785
Cont_P07589	Fibronectin OS=Bos taurus OX=9913 GN=FN1 PE=1 SV=4	337.517	cell adhesion;cell organization and biogenesis;stress response;developmental processes;other biological processes	non-structural extracellular	signal transduction activity or receptor binding;other molecular function			FN1	P07589			0.553450172742796	0.35834247597224	835883.8306505851	952169.9232567847	590914.7645248	482619.7682389803	602598.7403397557	-0.6600214012146457	-0.7924154436110592
Q80X90	Filamin-B [OS=Mus musculus]	335.882	cell organization and biogenesis;stress response;other biological processes	plasma membrane;other membranes;cytosol;cytoskeleton;other cell component	cytoskeletal activity;other molecular function	286940	ENSMUSG00000025278	Flnb	E9QNV9; mmu:286940; Q80X90; Q8VHX4; Q8VHX7; Q99KY3		ISG15 antiviral mechanism	0.936411452199724	0.872448101434609	2351112.5534752235	6048828.490809467	1.7547066707595836E7	1865154.4144755967	7592568.170254476	0.3279322018375229	-0.3340485310994022
Cont_P35527	Keratin, type I cytoskeletal 9 OS=Homo sapiens OX=9606 GN=KRT9 PE=1 SV=3	310.424	cell organization and biogenesis;other biological processes	cytosol;cytoskeleton	cytoskeletal activity	3857	ENSG00000171403	KRT9	hsa:3857; O00109; P35527; Q0IJ47; Q14665		Formation of the cornified envelope	0.873609880131656	0.516448827835279	3.250630567014273E7	4.1318104811136335E7	3.4478974092312835E7	9.369998400542612E7	5.1433611479478456E7	0.31593737616513196	1.5273291980404673
Cont_P04264	Keratin, type II cytoskeletal 1 OS=Homo sapiens OX=9606 GN=KRT1 PE=1 SV=6	306.58	cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes	non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component	bone, tooth or skin structural activity;other molecular function	3848	ENSG00000167768	KRT1	B2RA01; hsa:3848; P04264; P85925; P86104; Q14720; Q6GSJ0; Q9H298	Corticotropin-releasing hormone signaling	Formation of the cornified envelope; Neutrophil degranulation; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	0.873609880131656	0.254077056479593	1.3414412508194733E8	1.6528138436319932E8	1.1322276749996448E8	4.476405570139613E8	1.7631437693719265E8	0.09322587587347089	1.738556880584629
P06909	Complement factor H [OS=Mus musculus]	292.01	cell adhesion;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes	non-structural extracellular;plasma membrane;other membranes;mitochondrion;other cell component	other molecular function	12628	ENSMUSG00000026365	Cfh	mmu:12628; P06909; Q6NZK3		Regulation of Complement cascade	0.678323397545056	0.750662231008662	1.0566840244224759E7	1.036081717107911E7	1.3701110968154365E7	8439848.284125684	2.9357524779450033E7	1.502592540643395	-0.3242550682599269
P16546	Spectrin alpha chain, non-erythrocytic 1 [OS=Mus musculus]	291.854	cell organization and biogenesis	plasma membrane;other membranes;cytosol;cytoskeleton;other cell component	cytoskeletal activity;other molecular function	20740	ENSMUSG00000057738	Sptan1	A3KGU6; A3KGU8; P16546; Q8K380; Q9CT05	FAS pathway and stress induction of HSP regulation	Neutrophil degranulation; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Interaction between L1 and Ankyrins; COPI-mediated anterograde transport; RHOU GTPase cycle; RHOV GTPase cycle; Caspase-mediated cleavage of cytoskeletal proteins	0.929383260195332	0.870511801558508	1427277.73205798	3976922.979229001	9978258.42723309	2263434.85725903	8138355.29233573	1.0330846429966014	0.6652476915056309
Cont_P13645	Keratin, type I cytoskeletal 10 OS=Homo sapiens OX=9606 GN=KRT10 PE=1 SV=6	286.713	cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes	plasma membrane;cytosol;cytoskeleton;other cell component	bone, tooth or skin structural activity;other molecular function	3858	ENSG00000186395	KRT10	hsa:3858; P13645; Q14664; Q8N175		Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	0.829734761131295	0.246231694954624	9.409796786421584E7	1.13950700113199E8	6.71694026550819E7	3.19749190691826E8	1.0914077913761683E8	-0.06221954053344878	1.7647052355257151
Cont_P35908	Keratin, type II cytoskeletal 2 epidermal OS=Homo sapiens OX=9606 GN=KRT2 PE=1 SV=2	284.975	cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes	plasma membrane;cytosol;cytoskeleton;other cell component	bone, tooth or skin structural activity;cytoskeletal activity	3849	ENSG00000172867	KRT2	hsa:3849; P35908; Q4VAQ2		Formation of the cornified envelope	0.912218866069753	0.309041843038519	2.9357809740500167E7	3.415287514761583E7	1.8123682357997265E7	7.640800383787991E7	3.617272663897294E7	0.0828953136099207	1.3799794314161524
Q62059	Versican core protein [OS=Mus musculus]	279.715	cell adhesion;developmental processes	non-structural extracellular;extracellular matrix;other cell component	other molecular function			Vcan	Q62058; Q62059; Q9CUU0		ECM proteoglycans; Glycosaminoglycan-protein linkage region biosynthesis; CS/DS degradation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; CS-GAG biosynthesis; DS-GAG biosynthesis	0.854305439376382	0.478009151463064	9.037034497028168E7	9.467651077277745E7	6.45815395615126E7	5.89459061512507E7	9.510262638582683E7	0.006478645904816274	-0.6164578097523755
P10493	Nidogen-1 [OS=Mus musculus]	275.191	cell adhesion;cell organization and biogenesis;developmental processes;other biological processes	non-structural extracellular;extracellular matrix;other cell component	other molecular function	18073	ENSMUSG00000005397	Nid1	mmu:18073; P10493; Q3TKX9; Q8BQI3; Q8C3U8; Q8C9P6		Laminin interactions; Degradation of the extracellular matrix	0.013229256333524	1.0740690550749E-5	1.2120394496125467E8	1.2671518083095133E8	1.3280012723821335E8	9146738.193898173	3.1971627034095198E7	-1.9867253039502062	-3.7280354888144775
O88207	Collagen alpha-1(V) chain [OS=Mus musculus]	275.025	cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes	extracellular matrix;other cell component	extracellular structural activity;other molecular function	12831	ENSMUSG00000026837	Col5a1	A3KGE3; mmu:12831; O88207; Q3UG94; Q6F6B0	Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion	ECM proteoglycans; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; MET activates PTK2 signaling	0.189625712887896	0.302671730722046	3577832.3612721	8562033.320911517	1.35263273373913E7	1386447.3981625708	3098568.0509616495	-1.4663517968660993	-1.367692910200405
P37889	Fibulin-2 [OS=Mus musculus]	269.894	other biological processes	non-structural extracellular	other molecular function	14115	ENSMUSG00000064080	Fbln2	G5E8B3; mmu:14115; P37889; Q9WUI2		Molecules associated with elastic fibres	0.453005417011507	0.290132264062119	6.556805587417743E7	8.021475911820169E7	7.423633042764436E7	3.00676966042863E7	4.93487108032657E7	-0.700855313955825	-1.1247787672414093
Q8VHX6	Filamin-C [OS=Mus musculus]	249.498	cell organization and biogenesis;other biological processes	plasma membrane;other membranes;cytosol;cytoskeleton;other cell component	cytoskeletal activity	68794	ENSMUSG00000068699	Flnc	B2RY80; B9EKT2; mmu:68794; Q6PAI6; Q8VHX6; Q9JJ38		Cell-extracellular matrix interactions	0.976873891151678	0.933437821008547	1016453.1391661359	2089599.8263247435	6137929.999733508	1136666.5742976035	4459384.47065665	1.093617906439173	0.1612654161431754
Q04857	Collagen alpha-1(VI) chain [OS=Mus musculus]	248.981	cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes	non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component	other molecular function	12833	ENSMUSG00000001119	Col6a1	mmu:12833; Q04857		ECM proteoglycans; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Signaling by PDGF; NCAM1 interactions	0.0353343473113635	0.115965329440656	5.0068940213435836E7	6.914260176814564E7	6.089353622953653E7	1.4473176745930666E7	1.9886194591010433E7	-1.7978076624001023	-1.7905343022837863
Cont_Q2UVX4	Complement C3 OS=Bos taurus OX=9913 GN=C3 PE=1 SV=2	247.154	cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes	non-structural extracellular;other cell component	signal transduction activity or receptor binding;enzyme regulator activity	280677	ENSBTAG00000017280	C3	bta:280677; Q2KIZ4; Q2UVX4	Complement and coagulation cascades; Complement activation, classical pathway	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Neutrophil degranulation; Peptide ligand-binding receptors; G alpha (i) signalling events; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade; Alternative complement activation; Activation of C3 and C5	0.87421335771164	0.591028379533681	1.84550126489547E7	1.5291804049274266E7	1.004110180479193E7	1.196234797265725E7	1.6127794015790733E7	0.07679049940163296	-0.6255121365240285
Q62261	Spectrin beta chain, non-erythrocytic 1 [OS=Mus musculus]	244.684	cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes	plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component	cytoskeletal activity;other molecular function	20742	ENSMUSG00000020315	Sptbn1	A2AFU1; mmu:20742; Q3TEM7; Q5SQL8; Q5SQL9; Q62261; Q9QWJ7		COPI-mediated anterograde transport; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; RHOU GTPase cycle; Interaction between L1 and Ankyrins; RHOV GTPase cycle	0.937876734191067	0.664971370235365	920886.7046363313	2921004.358024217	7076390.486598223	2299979.2063157237	6417771.720584608	1.1356079634194152	1.3205252384353656
Q640N1	Adipocyte enhancer-binding protein 1 [OS=Mus musculus]	239.707	protein metabolism;other biological processes	nucleus;other cell component	nucleic acid binding activity;other molecular function	11568	ENSMUSG00000020473	Aebp1	mmu:11568; O88442; Q3TVV5; Q3TWA7; Q3TX56; Q3TXB2; Q5NCI9; Q61281; Q640N1			0.534291750451691	0.145805028390539	3.9556778473622136E7	4.1143769603117764E7	4.694818678152809E7	1.8648394999714002E7	3.1901344171106894E7	-0.3670567664350577	-1.0848734687320578
P57780	Alpha-actinin-4 [OS=Mus musculus]	239.42	cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes	cytoskeleton;nucleus;other cell component	cytoskeletal activity;other molecular function	60595	ENSMUSG00000054808	Actn4	mmu:60595; P57780	Primary focal segmental glomerulosclerosis (FSGS)	Platelet degranulation	0.921882153462399	0.968364585136618	4580996.01302682	9830280.285985528	3.01659424163415E7	4440337.50144963	1.1658414413951913E7	0.24606713307090775	-0.044991970039703705
Q7TPR4	Alpha-actinin-1 [OS=Mus musculus]	235.529	cell adhesion;cell organization and biogenesis;other biological processes	plasma membrane;other membranes;cytoskeleton;other cell component	signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function	109711	ENSMUSG00000015143	Actn1	mmu:109711; Q7TPR4	Regulation of actin cytoskeleton; Integrin-mediated cell adhesion; Focal adhesion	Platelet degranulation ; RHOF GTPase cycle; RHOBTB2 GTPase cycle; RHOD GTPase cycle; Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	0.974207409660283	0.837231569641376	2525588.7379033365	6210475.170240924	1.99706831247943E7	3717490.65968503	9946958.94260729	0.679551866892813	0.5577093849474224
P02468	Laminin subunit gamma-1 [OS=Mus musculus]	230.882	cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes	non-structural extracellular;extracellular matrix;other cell component	extracellular structural activity;other molecular function			Lamc1	P02468			0.3041568870489	0.368062651583427	7327169.184632126	1.61740059690847E7	2.6285654209548533E7	3246292.9185144133	7951596.802164167	-1.0243605391840713	-1.1744627453696188
Q91ZX7	Prolow-density lipoprotein receptor-related protein 1 [OS=Mus musculus]	230.497	other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes	plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component	signal transduction activity or receptor binding;other molecular function	16971		Lrp1	mmu:16971; Q61291; Q91ZX7; Q920Y4	Statin pathway; Wnt signaling pathway	Scavenging of heme from plasma; Retinoid metabolism and transport	0.687557067265551	0.74148782464906	3548407.5296101067	7355877.025944923	9948732.886846773	2243610.9879279765	5724840.5342227295	-0.3616618538572069	-0.6613491570014096
Cont_P60712	Actin, cytoplasmic 1 OS=Bos taurus OX=9913 GN=ACTB PE=1 SV=1	225.45	cell organization and biogenesis;stress response;developmental processes;other biological processes	plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component	enzyme regulator activity;cytoskeletal activity;other molecular function	100033878; 100135470; 100173832; 101844587; 102139853; 11461; 118833809; 280979; 396526; 403580; 414396; 443052; 450133; 60; 81822	ENSBTAG00000026199; ENSCAFG00000016020; ENSCAFG00030015381; ENSCAFG00040015695; ENSCPOG00000013467; ENSG00000075624; ENSMAUG00000008763; ENSMUSG00000029580; ENSOARG00040012985; ENSOARG00180022443; ENSOARG00185023855; ENSOARG00215030140; ENSOARG00225009314; ENSPPYG00000017336; ENSPTRG00000018890; ENSRNOG00000034254; ENSSSCG00000007585; ENSSSCG00030003451; ENSSSCG00035038792; ENSSSCG00040049462; ENSSSCG00045027458; ENSSSCG00050065025; ENSSSCG00055012597; ENSSSCG00060019124; ENSSSCG00065037921; ENSSSCG00070011353; ENSSSCG00105030144; ENSSSCG00110026965; ENSSSCG00115013637; ENSSSCG00130033784	Actb; ACTB	A5D961; A5PKA1; bta:280979; cfa:403580; cpoc:100135470; csab:103246953; ecb:100033878; gga:396526; hsa:60; maua:101844587; mmu:11461; O18840; oas:443052; P02570; P60706; P60707; P60708; P60709; P60710; P60711; P60712; P60713; P70514; P99021; pon:100173832; ptr:450133; Q11209; Q11211; Q3SZD2; Q3TI89; Q3TVP6; Q4L0Y2; Q4R561; Q5R1X3; Q5R582; Q5R6G0; Q64316; Q6QAQ1; Q6ZWM3; Q711N9; Q71FK5; Q75MN2; Q76N69; Q8MIJ0; Q8SPX4; Q95164; Q96B34; Q96HG5; rno:81822; ssc:414396	FAS pathway and stress induction of HSP regulation; Actin cytoskeleton regulation; Myometrial relaxation and contraction pathways; Focal adhesion; Arrhythmogenic right ventricular cardiomyopathy; Pathogenic Escherichia coli infection; Common pathways underlying drug addiction; Myometrial relaxation and contraction pathways; Focal adhesion; Fas ligand pathway and stress induction of heat shock proteins; Pathogenic Escherichia coli infection; Arrhythmogenic right ventricular cardiomyopathy; Focal adhesion; Myometrial relaxation and contraction pathways; Regulation of actin cytoskeleton; Myometrial relaxation and contraction pathways; Ebola virus infection in host; Acute viral myocarditis; Thermogenesis; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Overlap between signal transduction pathways contributing to LMNA laminopathies; Pleural mesothelioma; Regulation of actin cytoskeleton; Network map of SARS-CoV-2 signaling; Regulation of actin cytoskeleton; Regulation of actin cytoskeleton; Focal adhesion	Formation of the canonical BAF (cBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); Regulation of actin dynamics for phagocytic cup formation; EPH-ephrin mediated repulsion of cells; Formation of annular gap junctions; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; RHO GTPases Activate Formins; RHOF GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; B-WICH complex positively regulates rRNA expression; Regulation of CDH1 Function; Formation of the dystrophin-glycoprotein complex (DGC); Formation of the canonical BAF (cBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); RHO GTPases Activate WASPs and WAVEs; UCH proteinases; DNA Damage Recognition in GG-NER; Formation of the non-canonical BAF (ncBAF) complex; RHO GTPases activate IQGAPs; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Cell-extracellular matrix interactions; MAP2K and MAPK activation; Interaction between L1 and Ankyrins; RHOF GTPase cycle; DNA Damage Recognition in GG-NER; MAP2K and MAPK activation; RHO GTPases Activate Formins; Clathrin-mediated endocytosis; UCH proteinases; RHOF GTPase cycle; DNA Damage Recognition in GG-NER; EPH-ephrin mediated repulsion of cells; VEGFA-VEGFR2 Pathway; Regulation of actin dynamics for phagocytic cup formation; Adherens junctions interactions; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); RHO GTPases Activate WASPs and WAVEs; B-WICH complex positively regulates rRNA expression; Regulation of CDH1 Function; EPHB-mediated forward signaling; Formation of the non-canonical BAF (ncBAF) complex; Formation of the canonical BAF (cBAF) complex; Formation of annular gap junctions; RHO GTPases activate IQGAPs; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; RHO GTPases Activate WASPs and WAVEs; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RHO GTPases activate IQGAPs; RHO GTPases Activate Formins; RHOF GTPase cycle; Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs); B-WICH complex positively regulates rRNA expression; Signaling by BRAF and RAF1 fusions; UCH proteinases; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; VEGFA-VEGFR2 Pathway; Formation of the dystrophin-glycoprotein complex (DGC); Factors involved in megakaryocyte development and platelet production; Regulation of MITF-M-dependent genes involved in pigmentation; Formation of the canonical BAF (cBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); EPH-ephrin mediated repulsion of cells; HATs acetylate histones; Interaction between L1 and Ankyrins; Prefoldin mediated transfer of substrate to CCT/TriC; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Adherens junctions interactions; Regulation of CDH1 Function; Formation of the non-canonical BAF (ncBAF) complex; DNA Damage Recognition in GG-NER; Formation of the polybromo-BAF (pBAF) complex; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Formation of annular gap junctions; Folding of actin by CCT/TriC; Cell-extracellular matrix interactions; MAP2K and MAPK activation; RHO GTPases Activate Formins; Recycling pathway of L1; RHO GTPases activate IQGAPs; Clathrin-mediated endocytosis; Formation of the dystrophin-glycoprotein complex (DGC); EPHB-mediated forward signaling; UCH proteinases; B-WICH complex positively regulates rRNA expression; Adherens junctions interactions; Formation of the non-canonical BAF (ncBAF) complex; Formation of annular gap junctions; Formation of the polybromo-BAF (pBAF) complex; VEGFA-VEGFR2 Pathway; Cell-extracellular matrix interactions; RHO GTPases Activate WASPs and WAVEs; Regulation of CDH1 Function; Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; UCH proteinases; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); Formation of the polybromo-BAF (pBAF) complex; B-WICH complex positively regulates rRNA expression; DNA Damage Recognition in GG-NER; Formation of the canonical BAF (cBAF) complex; RHO GTPases Activate Formins; Regulation of CDH1 Function; Interaction between L1 and Ankyrins; RHOF GTPase cycle; Formation of the non-canonical BAF (ncBAF) complex; Adherens junctions interactions; Formation of the dystrophin-glycoprotein complex (DGC); VEGFA-VEGFR2 Pathway; RHO GTPases Activate WASPs and WAVEs; Cell-extracellular matrix interactions; EPHB-mediated forward signaling; MAP2K and MAPK activation; Recycling pathway of L1; RHO GTPases activate IQGAPs; Formation of annular gap junctions; B-WICH complex positively regulates rRNA expression; UCH proteinases; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); MAP2K and MAPK activation; Formation of the polybromo-BAF (pBAF) complex; RHO GTPases Activate Formins; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases Activate WASPs and WAVEs; Formation of the dystrophin-glycoprotein complex (DGC); VEGFA-VEGFR2 Pathway; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; DNA Damage Recognition in GG-NER; RHOF GTPase cycle; Cell-extracellular matrix interactions; Adherens junctions interactions; Formation of the non-canonical BAF (ncBAF) complex; Formation of the canonical BAF (cBAF) complex; RHO GTPases activate IQGAPs; Regulation of CDH1 Function; Gap junction degradation; Formation of annular gap junctions; Regulation of actin dynamics for phagocytic cup formation; RHOF GTPase cycle; Clathrin-mediated endocytosis; RHO GTPases Activate Formins; Cell-extracellular matrix interactions; VEGFA-VEGFR2 Pathway; Adherens junctions interactions; RHO GTPases activate IQGAPs; UCH proteinases; EPHB-mediated forward signaling; MAP2K and MAPK activation; RHO GTPases Activate WASPs and WAVEs; Formation of the dystrophin-glycoprotein complex (DGC); Formation of annular gap junctions; Formation of the canonical BAF (cBAF) complex; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of the non-canonical BAF (ncBAF) complex; Regulation of CDH1 Function	0.946568086066385	0.963278515868644	4.828873920581084E7	6.5074451419171505E7	1.9003581889821532E8	5.335770948168167E7	1.0984219759318356E8	0.7552692448247239	0.14400994044310264
P63260	Actin, cytoplasmic 2 [OS=Mus musculus]	217.791	cell organization and biogenesis;stress response;developmental processes;other biological processes	non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component	cytoskeletal activity;other molecular function	11465	ENSMUSG00000062825	Actg1	mmu:11465; P02571; P14104; P63260; P99022	Myometrial relaxation and contraction pathways; Regulation of actin cytoskeleton; Focal adhesion	Platelet degranulation ; RHO GTPases activate IQGAPs; Adherens junctions interactions; Regulation of CDH1 Function; RHO GTPases Activate Formins; Regulation of actin dynamics for phagocytic cup formation; Interaction between L1 and Ankyrins; MAP2K and MAPK activation; Recycling pathway of L1; Clathrin-mediated endocytosis; Formation of the dystrophin-glycoprotein complex (DGC); EPHB-mediated forward signaling; RHOF GTPase cycle; Formation of annular gap junctions; VEGFA-VEGFR2 Pathway; Cell-extracellular matrix interactions; RHO GTPases Activate WASPs and WAVEs; RHOBTB2 GTPase cycle	0.85271451854395	0.731487178650893	145698.54484736864	254666.434448248	751276.7484437827	126248.83655432604	256671.2110968777	0.011312666587244136	-0.20671637589735362
P33434	72 kDa type IV collagenase [OS=Mus musculus]	212.03	cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes	extracellular matrix;plasma membrane;other membranes;cytoskeleton;mitochondrion;nucleus;other cell component	other molecular function	17390	ENSMUSG00000031740	Mmp2	mmu:17390; P33434	Lung fibrosis; IL-3 signaling pathway; Matrix metalloproteinases	Collagen degradation; Extra-nuclear estrogen signaling; EPH-ephrin mediated repulsion of cells; Activation of Matrix Metalloproteinases	0.993994198406889	0.34519376377552	2.11513119484971E7	6.116415043649567E7	9.997674520202683E7	5.359802560613743E7	8.73371018908004E7	0.5139083514604432	1.3414327051154107
P19096	Fatty acid synthase [OS=Mus musculus]	203.372	other metabolic processes;stress response;other biological processes	plasma membrane;other membranes;cytosol;ER/Golgi;other cell component	other molecular function	14104	ENSMUSG00000025153	Fasn	B1ATU8; mmu:14104; P19096; Q6PB72; Q8C4Z0; Q9EQR0	Fatty acid biosynthesis; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-9 fatty acid synthesis; Elongation of (very) long chain fatty acids	Fatty acyl-CoA biosynthesis; Vitamin B5 (pantothenate) metabolism	0.87421335771164	0.746782404466558	1389784.0897720233	2729524.669883373	1.0491585001659483E7	892753.3234074336	2995475.6339221266	0.1341353617926422	-0.6385272655543875
Cont_Q3SZ57	Alpha-fetoprotein OS=Bos taurus OX=9913 GN=AFP PE=2 SV=1	202.89	other metabolic processes;developmental processes;other biological processes	non-structural extracellular;other cell component	other molecular function	506011	ENSBTAG00000017131	AFP	bta:506011; Q3SZ57		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation	0.938859506774495	0.699570390946254	4.5317948160280704E7	3.6151020512819335E7	2.37647047257016E7	3.679174310656657E7	4.2915740009991035E7	0.2474705016386588	-0.30070051296273864
P48678	Prelamin-A/C [OS=Mus musculus]	202.607	cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes	other membranes;cytoskeleton;nucleus;other cell component	other molecular function	16905	ENSMUSG00000028063	Lmna	B3RH23; B3RH24; mmu:16905; P11516; P48678; P97859; Q3TIH0; Q3TTS8; Q3U733; Q3U7I5; Q3UCA0; Q3UCJ8; Q3UCU3; Q91WF2; Q9DC21	Adipogenesis genes; FAS pathway and stress induction of HSP regulation		0.236076921565588	0.901149690306505	4134986.871037207	1.1058985470826533E7	3.2189609583199937E7	6289356.16248022	5.369543399964929E7	2.2795803719185894	0.6050295881452582
Q02788	Collagen alpha-2(VI) chain [OS=Mus musculus]	202.37	cell adhesion;signal transduction;other biological processes	non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component	other molecular function	12834	ENSMUSG00000020241	Col6a2	mmu:12834; Q02788; Q05505; Q8C972; Q8K229	Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion	ECM proteoglycans; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation	0.156641881403766	0.0961283818482991	4.136492509189963E7	5.21291258166705E7	5.586648846604673E7	1.173163988850227E7	2.0595787144729633E7	-1.3397404015276635	-1.8180032772865453
P97927	Laminin subunit alpha-4 [OS=Mus musculus]	199.33	cell adhesion;developmental processes;other biological processes	non-structural extracellular;extracellular matrix;other cell component	signal transduction activity or receptor binding	16775	ENSMUSG00000019846	Lama4	mmu:16775; O88785; P70409; P97927; Q14BF2	Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion	Formation of the dystrophin-glycoprotein complex (DGC); Laminin interactions; MET activates PTK2 signaling	0.329011090732691	0.50594120050135	5125646.74812024	1.037511250312096E7	1.8735571837149E7	3065544.409694903	5760601.1965567535	-0.8488356911350236	-0.7415907489564434
P20152	Vimentin [OS=Mus musculus]	183.446	cell organization and biogenesis;stress response;developmental processes;other biological processes	plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component	cytoskeletal activity;nucleic acid binding activity;other molecular function	22352	ENSMUSG00000026728	Vim	mmu:22352; O08704; P20152; Q8CCH1	Spinal cord injury; Primary focal segmental glomerulosclerosis (FSGS); Alpha 6 beta 4 integrin signaling pathway	Aggrephagy; Striated Muscle Contraction; Caspase-mediated cleavage of cytoskeletal proteins; RHOBTB1 GTPase cycle	0.873609880131656	0.840672080806375	7365249.698992513	3.3401280645601466E7	8.643236711147267E7	1.292797841903164E7	7.464184195594883E7	1.1600811699488573	0.8116903529805907
Q64727	Vinculin [OS=Mus musculus]	182.753	cell adhesion;cell organization and biogenesis;developmental processes;other biological processes	plasma membrane;other membranes;cytoskeleton;other cell component	cytoskeletal activity;other molecular function	22330	ENSMUSG00000021823	Vcl	mmu:22330; Q64727; Q8BP32; Q8BS46; Q922C5; Q922D9	Primary focal segmental glomerulosclerosis (FSGS); IL-3 signaling pathway; Regulation of actin cytoskeleton; Integrin-mediated cell adhesion; Focal adhesion	Neutrophil degranulation; High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells; Platelet degranulation ; MAP2K and MAPK activation; Smooth Muscle Contraction; Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells; Regulation of CDH1 Function	0.964629994744883	0.977491813528386	1953982.7579073233	4840837.086136207	1.55412767194393E7	2359150.5810886133	6758257.200309387	0.48139471401466805	0.2718497696931775
Q8K4G1	Latent-transforming growth factor beta-binding protein 4 [OS=Mus musculus]	180.216	cell-cell signaling;cell organization and biogenesis;transport;signal transduction	non-structural extracellular;extracellular matrix	other molecular function	108075	ENSMUSG00000040488	Ltbp4	E9QPD9; mmu:108075; Q8K4G0; Q8K4G1		TGF-beta receptor signaling activates SMADs; Molecules associated with elastic fibres	0.775297640004946	0.703189639676216	1469976.6770863	2473680.681365607	4126124.1405319436	2657641.7444799202	7291299.088613093	1.5595166020390654	0.8543533743061732
Q68FD5	Clathrin heavy chain 1 [OS=Mus musculus]	180.117	cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes	plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component	nucleic acid binding activity;other molecular function	67300	ENSMUSG00000047126	Cltc	mmu:67300; Q68FD5	IL-7 signaling pathway; Kit receptor signaling pathway	MHC class II antigen presentation; Recycling pathway of L1; Cargo recognition for clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis; LDL clearance; Retrograde neurotrophin signalling; Formation of annular gap junctions; Lysosome Vesicle Biogenesis; WNT5A-dependent internalization of FZD4; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation; RHOU GTPase cycle; RHOV GTPase cycle	0.688274955487563	0.946476383814868	1426606.2225329466	2101059.0869428	7198111.7488871245	2078296.563295177	6830362.818457293	1.7008454796013681	0.5428143634365035
P02469	Laminin subunit beta-1 [OS=Mus musculus]	179.863	cell adhesion;cell organization and biogenesis;developmental processes;other biological processes	non-structural extracellular;extracellular matrix;nucleus;other cell component	signal transduction activity or receptor binding;extracellular structural activity;other molecular function	16777	ENSMUSG00000002900	Lamb1	E9PXZ9; P02469	Focal adhesion: PI3K-Akt-mTOR signaling pathway; Inflammatory response pathway; Alpha 6 beta 4 integrin signaling pathway; Focal adhesion		0.269583968882479	0.356773085915651	1.4326337702720901E7	1.8407714250900764E7	2.406357201653607E7	2.1078383512013834E7	1.149610392953332E7	-0.6791654838846833	0.5570943768396376
Q01853	Transitional endoplasmic reticulum ATPase [OS=Mus musculus]	179.055	cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;other biological processes	other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component	signal transduction activity or receptor binding;enzyme regulator activity;other molecular function	269523	ENSMUSG00000028452	Vcp	mmu:269523; Q01853; Q3TFH9; Q3TIM2; Q3TXN9; Q6PI18; Q8BSR6; Q8CEG4	IL-9 signaling pathway	RHOH GTPase cycle; Neutrophil degranulation; Protein methylation; Ovarian tumor domain proteases; Neddylation; ABC-family proteins mediated transport; Translesion Synthesis by POLH; Hedgehog ligand biogenesis; KEAP1-NFE2L2 pathway; HSF1 activation; N-glycan trimming in the ER and Calnexin/Calreticulin cycle; Josephin domain DUBs	0.953038161729767	0.901149690306505	5338414.413398174	9329554.935730066	2.5532499977727503E7	4463650.11042755	1.2770955118061693E7	0.45298626139298054	-0.2581873602655405
Q03350	Thrombospondin-2 [OS=Mus musculus]	178.303	cell adhesion;other biological processes	non-structural extracellular;extracellular matrix;other cell component	other molecular function	21826	ENSMUSG00000023885	Thbs2	mmu:21826; Q03350; Q8CG21	Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion	Signaling by PDGF; O-glycosylation of TSR domain-containing proteins	0.792896707923278	0.620448351319483	7439397.130180354	1.1102887711296873E7	1.7857870851453733E7	4211942.301314384	1.05864549049655E7	-0.06871539719065865	-0.820700040470399
Q80YX1	Tenascin [OS=Mus musculus]	175.9	cell adhesion;cell-cell signaling;cell organization and biogenesis;stress response;developmental processes;other biological processes	non-structural extracellular;extracellular matrix;other cell component	signal transduction activity or receptor binding;other molecular function	21923	ENSMUSG00000028364	Tnc	mmu:21923; Q64706; Q80YX1; Q80YX2	Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion	Integrin cell surface interactions; ECM proteoglycans; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation	1.08858887903907E-8	0.00972980877962454	1449614.4281484466	1.2106484504902953E7	3597849.650032737	96243.5238250637	211010.04547923067	-5.842324501720179	-3.9128359438342706
Q61147	Ceruloplasmin [OS=Mus musculus]	175.43	cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes	non-structural extracellular	other molecular function	12870	ENSMUSG00000003617	Cp	mmu:12870; Q61147; Q6P5C8		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Iron uptake and transport; Metal ion SLC transporters	0.114472406028442	0.217345018530886	4703216.257241024	9598922.193485493	1.8258425380319133E7	1756646.5467629798	3587720.1567995367	-1.4198050591681202	-1.4208237326658222
Q3UQ28	Peroxidasin homolog [OS=Mus musculus]	173.636	cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes	extracellular matrix;ER/Golgi;other cell component	extracellular structural activity;other molecular function	69675	ENSMUSG00000020674	Pxdn	A4FU83; E9QNQ9; mmu:69675; Q3UQ28		Crosslinking of collagen fibrils	0.414844709855988	0.622521206052951	3468268.863888983	1.0141728842991263E7	7424302.20024892	1748064.7562207088	5865453.59009746	-0.789989022164196	-0.988457112373562
Q61316	Heat shock 70 kDa protein 4 [OS=Mus musculus]	169.044	protein metabolism;other metabolic processes	other cell component	other molecular function			Hspa4	Q61316		Regulation of HSF1-mediated heat shock response	0.937908804051419	0.905946265571965	1715523.4149199834	3885769.0116153997	1.2475039717842167E7	1450318.0074060035	4790126.20554149	0.3018635242804291	-0.2422795462920771
Cont_P02533	Keratin, type I cytoskeletal 14 OS=Homo sapiens OX=9606 GN=KRT14 PE=1 SV=4	164.831	cell organization and biogenesis;other biological processes	plasma membrane;cytosol;cytoskeleton;nucleus;other cell component	cytoskeletal activity;other molecular function	3861	ENSG00000186847	KRT14	hsa:3861; P02533; Q14715; Q53XY3; Q9BUE3; Q9UBN2; Q9UBN3; Q9UCY4	Corticotropin-releasing hormone signaling	Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin; Developmental Lineage of Mammary Gland Myoepithelial Cells; Type I hemidesmosome assembly	0.735573385767802	0.645534074006669	1.0299655985485494E7	9892865.41378706	7326107.9926405	2.9333304518974166E7	9460012.597296894	-0.06454634544610054	1.5099434544998684
P11499	Heat shock protein HSP 90-beta [OS=Mus musculus]	164.719	cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes	non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component	enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function	15516	ENSMUSG00000023944	Hsp90ab1	mmu:15516; O89078; P11499; Q3UIQ7	Focal adhesion: PI3K-Akt-mTOR signaling pathway	Neutrophil degranulation; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of actin dynamics for phagocytic cup formation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Attenuation phase; Estrogen-dependent gene expression; Sema3A PAK dependent Axon repulsion; Aryl hydrocarbon receptor signalling; DDX58/IFIH1-mediated induction of interferon-alpha/beta; HSF1 activation; RHOBTB2 GTPase cycle; The NLRP3 inflammasome	0.952333191127893	0.975071223710592	1.0807613687705928E7	3.193268303009924E7	8.29576662608192E7	1.1608041082716169E7	4.22825068683512E7	0.4050271392280359	0.10307651810960865
Q9JKF1	Ras GTPase-activating-like protein IQGAP1 [OS=Mus musculus]	163.926	cell organization and biogenesis;developmental processes;signal transduction;other biological processes	plasma membrane;other membranes;cytoskeleton;nucleus;other cell component	enzyme regulator activity;other molecular function	29875	ENSMUSG00000030536	Iqgap1	G3UW45; mmu:29875; Q9JKF1	G13 signaling pathway; Regulation of actin cytoskeleton	RHO GTPases activate IQGAPs; Neutrophil degranulation; RAC1 GTPase cycle; RAC2 GTPase cycle; RHOA GTPase cycle; MAP2K and MAPK activation; RHOQ GTPase cycle; RHOC GTPase cycle; RHOU GTPase cycle; RHOV GTPase cycle; Nephrin family interactions	0.830676695521175	0.777195460870953	331165.4406654323	1068898.0084058929	3041433.200354057	944145.2185002686	3795509.9873349466	1.8281695465197003	1.5114566510612586
P52480	Pyruvate kinase PKM [OS=Mus musculus]	163.393	cell organization and biogenesis;other metabolic processes;other biological processes	cytosol;ER/Golgi;nucleus;other cell component	nucleic acid binding activity;kinase activity;other molecular function	18746	ENSMUSG00000032294	Pkm	mmu:18746; P52480; Q3TBV8; Q3TBW5; Q3TC59; Q3U1X3; Q3U5P6; Q4VC20; Q64484; Q91YI8; Q9CWB1	Glycolysis and gluconeogenesis; Purine metabolism	Neutrophil degranulation; Pyruvate metabolism; Glycolysis; Regulation of pyruvate metabolism	0.938859506774495	0.958705855138011	1.1706302394897154E7	1.6687028973496003E7	3.53200761892009E7	1.3595916090065738E7	3.1698865102110166E7	0.9257040749614063	0.215887911460558
P63017	Heat shock cognate 71 kDa protein [OS=Mus musculus]	161.557	cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;other biological processes	non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component	signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function	15481	ENSMUSG00000015656	Hspa8	mmu:15481; P08109; P12225; P63017; Q3U6R0; Q3U764; Q3U7D7; Q3U7E2; Q3U9B4; Q3U9G0; Q3UGM0; Q5FWJ6; Q62373; Q62374; Q62375; Q6NZD0	Mapk signaling pathway; Exercise-induced circadian regulation	Neutrophil degranulation; mRNA Splicing - Major Pathway; Regulation of HSF1-mediated heat shock response; PKR-mediated signaling; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis; Attenuation phase; Lysosome Vesicle Biogenesis; GABA synthesis, release, reuptake and degradation; AUF1 (hnRNP D0) binds and destabilizes mRNA; Protein methylation	0.987939278265184	0.709593139419252	1.5723480869725833E7	2.2348098618015703E7	7.359719450565854E7	1.2001189016638666E7	3.440867978172333E7	0.6226204469568586	-0.38974328950384013
Q9JHU4	Cytoplasmic dynein 1 heavy chain 1 [OS=Mus musculus]	161.009	cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes	cytoskeleton;other cell component	cytoskeletal activity;other molecular function	13424	ENSMUSG00000018707	Dync1h1	E9QM71; mmu:13424; Q9JHU4		MHC class II antigen presentation; Neutrophil degranulation; Separation of Sister Chromatids; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; COPI-mediated anterograde transport; Recruitment of NuMA to mitotic centrosomes; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-independent Golgi-to-ER retrograde traffic; Aggrephagy; Anchoring of the basal body to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; AURKA Activation by TPX2	0.771389136401717	0.695927216301667	451351.8596347517	1275535.4534856554	3370818.0273642703	1462326.6297541	5162177.518126	2.0168767548265785	1.695941135437884
Q99K41	EMILIN-1 [OS=Mus musculus]	157.011	cell adhesion;cell organization and biogenesis;developmental processes;other biological processes	non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component	signal transduction activity or receptor binding;extracellular structural activity;other molecular function	100952	ENSMUSG00000029163	Emilin1	mmu:100952; Q99K41		Molecules associated with elastic fibres	0.169879542413978	0.0921665663508908	1671715.86234765	5498413.09956387	5014687.354848887	384416.66366236034	2364922.89508055	-1.2172221542664499	-2.120586876331411
Q61879	Myosin-10 [OS=Mus musculus]	146	cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes	plasma membrane;other membranes;cytosol;cytoskeleton;other cell component	cytoskeletal activity;nucleic acid binding activity;other molecular function	77579	ENSMUSG00000020900	Myh10	mmu:77579; Q5SV63; Q61879	Regulation of actin cytoskeleton	RHO GTPases activate PAKs	0.996007724449986	0.953146340313072	266023.60455562966	458865.269073755	1364536.1643212799	562909.3462758837	1089526.38375758	1.2475586126477243	1.0813483389566705
Cont_P00761	Trypsin OS=Sus scrofa OX=9823 PE=1 SV=1	143.502	protein metabolism;other biological processes	non-structural extracellular	other molecular function							0.822223648478518	0.960577895552113	3.334729419178533E9	2.1792138371661735E9	1.3557622678922963E9	4.479417756781787E9	2.35988129070601E9	0.11490652036236093	0.42574151472675936
P20029	Endoplasmic reticulum chaperone BiP [OS=Mus musculus]	142.966	protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes	non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component	enzyme regulator activity;translation activity;other molecular function	14828	ENSMUSG00000026864	Hspa5	mmu:14828; O35642; P20029; Q3UFF2; Q61630	Mapk signaling pathway	Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Regulation of HSF1-mediated heat shock response	0.916283277860523	0.985707795620743	7392689.481756757	8222965.927916382	1.797212351620547E7	8403011.594768586	1.57890948929286E7	0.9411977151669085	0.1848071583319896
Cont_P13647	Keratin, type II cytoskeletal 5 OS=Homo sapiens OX=9606 GN=KRT5 PE=1 SV=3	142.395	cell organization and biogenesis;other biological processes	cytosol;cytoskeleton;other cell component	bone, tooth or skin structural activity;cytoskeletal activity;other molecular function	3852	ENSG00000186081	KRT5	hsa:3852; P13647; Q6PI71; Q6UBJ0; Q8TA91		Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin; Developmental Lineage of Mammary Stem Cells; Developmental Lineage of Mammary Gland Myoepithelial Cells; Type I hemidesmosome assembly	0.873755746039336	0.2733017775894	7868513.182470503	9974982.226041706	1.0805570452735417E7	2.8752414910160065E7	1.3998817771053001E7	0.4889188179733309	1.8695201748341668
Cont_P08779	Keratin, type I cytoskeletal 16 OS=Homo sapiens OX=9606 GN=KRT16 PE=1 SV=4	140.751	cell organization and biogenesis;stress response;other biological processes	plasma membrane;cytosol;cytoskeleton	cytoskeletal activity	3868	ENSG00000186832	KRT16	A8K488; hsa:3868; P08779; P30654; Q16402; Q9UBG8	Vitamin D receptor pathway	Formation of the cornified envelope	0.82543231800733	0.895302208460818	3908256.3409277797	2249474.51763106	2096552.2825116366	5401589.786976026	2569640.8216647534	0.19197869304636359	0.46685898520849145
Cont_P02465	Collagen alpha-2(I) chain OS=Bos taurus OX=9913 GN=COL1A2 PE=1 SV=2	139.99		non-structural extracellular;extracellular matrix	extracellular structural activity;other molecular function	282188	ENSBTAG00000013472	COL1A2	A6QP13; bta:282188; O62649; P02465	Inflammatory response pathway; Focal adhesion	Fibronectin matrix formation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Collagen degradation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; Collagen chain trimerization; GPVI-mediated activation cascade; Platelet Aggregation (Plug Formation); Platelet Adhesion to exposed collagen; GP1b-IX-V activation signalling	0.731850662833984	0.549852418071669	85775.39066064726	163731.944383145	196860.296999494	48702.045776696206	54970.44581499727	-1.57460773663475	-0.8165814161100421
Cont_P12763	Alpha-2-HS-glycoprotein OS=Bos taurus OX=9913 GN=AHSG PE=1 SV=2	132.772	stress response;other biological processes	non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component	enzyme regulator activity	280988		AHSG	A6QLF7; bta:280988; P12763		Neutrophil degranulation; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation	0.946568086066385	0.335956814949331	8.712402787486216E8	6.41500953397899E8	4.2252677685996836E8	4.440672611032756E8	7.064361313920757E8	0.13910772352571524	-0.9722924411478902
P07901	Heat shock protein HSP 90-alpha [OS=Mus musculus]	132.382	cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes	plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component	signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function	15519	ENSMUSG00000021270	Hsp90aa1	mmu:15519; P07901	EBV LMP1 signaling; Focal adhesion: PI3K-Akt-mTOR signaling pathway; IL-6 signaling pathway; IL-2 signaling pathway	Regulation of necroptotic cell death; Recruitment of NuMA to mitotic centrosomes; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of actin dynamics for phagocytic cup formation; Neutrophil degranulation; Downregulation of ERBB2 signaling; Anchoring of the basal body to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; AURKA Activation by TPX2; Extra-nuclear estrogen signaling; Attenuation phase; Estrogen-dependent gene expression; Sema3A PAK dependent Axon repulsion; VEGFR2 mediated vascular permeability; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation; DDX58/IFIH1-mediated induction of interferon-alpha/beta; eNOS activation; HSF1 activation; RHOBTB2 GTPase cycle; Drug-mediated inhibition of ERBB2 signaling	0.974827674952665	0.968364585136618	1667357.9717776468	3968795.71909318	1.1896107480962433E7	1606774.576019598	6014683.841021903	0.5997875986262169	-0.0533963366441969
Q02819	Nucleobindin-1 [OS=Mus musculus]	131.152	signal transduction	non-structural extracellular;other membranes;ER/Golgi	enzyme regulator activity;nucleic acid binding activity;other molecular function	18220	ENSMUSG00000030824	Nucb1	mmu:18220; Q02819; Q3TU42; Q9CWA1; Q9D8J4; Q9DBL3		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation	0.0679830640731695	0.397987186613988	5493436.34719679	1.9240052036173E7	2.4992726743775133E7	2379424.5332984333	6548209.148806977	-1.5549403938694841	-1.2070961924278651
Q91V92	ATP-citrate synthase [OS=Mus musculus]	129.973	other metabolic processes	cytosol	other molecular function	104112	ENSMUSG00000020917	Acly	mmu:104112; Q91V92	Fatty acid biosynthesis	Neutrophil degranulation; Fatty acyl-CoA biosynthesis	0.626059420687734	0.643183834410259	1276919.6113413726	2339759.4103227933	7993361.0560920695	644183.8162072281	1777761.9344937534	-0.39629804848056854	-0.9871233812801825
A2ASQ1	Agrin [OS=Mus musculus]	128.989	cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes	non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cell component	signal transduction activity or receptor binding;other molecular function	11603	ENSMUSG00000041936	Agrn	A2ASP9; A2ASQ0; A2ASQ1; B2RWU1	Primary focal segmental glomerulosclerosis (FSGS)	ECM proteoglycans; Retinoid metabolism and transport; Glycosaminoglycan-protein linkage region biosynthesis; HS-GAG biosynthesis; HS-GAG degradation; Formation of the dystrophin-glycoprotein complex (DGC)	0.460727828548759	0.686318824668434	1695001.2322350666	3018900.06344302	4324221.40670855	1028829.4241236168	2045725.4701757336	-0.561410446190177	-0.72028251328634
Q61508	Extracellular matrix protein 1 [OS=Mus musculus]	127.379	stress response;developmental processes;signal transduction;other biological processes	non-structural extracellular	signal transduction activity or receptor binding;other molecular function	13601	ENSMUSG00000028108	Ecm1	mmu:13601; Q3U5Q5; Q61508		Platelet degranulation	2.27890527565265E-4	1.51989274634622E-7	5.132626536679041E7	6.196550035866306E7	5.7086940781247534E7	3515293.344106073	1.1331897286900917E7	-2.4510757802272813	-3.8679803006942106
Cont_P04259	Keratin, type II cytoskeletal 6B OS=Homo sapiens OX=9606 GN=KRT6B PE=1 SV=5	126.901	cell organization and biogenesis;other biological processes	cytosol;cytoskeleton	bone, tooth or skin structural activity;cytoskeletal activity	3854	ENSG00000185479	KRT6B	hsa:3854; P04259; P48669		Formation of the cornified envelope	0.854305439376382	0.937453377971347	1156058.5455969477	510017.07482617133	452820.542152991	1115770.6869766254	854901.7358096777	0.7452130553684702	-0.05117390608584228
P17182	Alpha-enolase [OS=Mus musculus]	126.804	other metabolic processes;developmental processes;other biological processes	plasma membrane;other membranes;cytosol;other cell component	nucleic acid binding activity;other molecular function	13806; 433182	ENSMUSG00000059040; ENSMUSG00000063524	Eno1	mmu:13806; mmu:433182; P17182; Q99KT7; Q9DCY7	Glycolysis and gluconeogenesis		0.720832939248489	0.858218537342417	9473047.660860082	1.1146559483992001E7	2.0899983974591535E7	1.3905788568310633E7	2.89416009584274E7	1.3765462552828784	0.5537850111265004
P08113	Endoplasmin [OS=Mus musculus]	126.346	cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes	non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cell component	signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function	22027	ENSMUSG00000020048	Hsp90b1	mmu:22027; P08113; P11427	Focal adhesion: PI3K-Akt-mTOR signaling pathway; Hypoxia-dependent self-renewal of myoblasts	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Scavenging by Class A Receptors; Trafficking and processing of endosomal TLR; Interleukin-4 and Interleukin-13 signaling	0.854305439376382	0.866766165039268	4030450.84914005	5006439.15200075	1.2828763316623202E7	6037105.20140975	1.2434595462188734E7	1.3125028215609296	0.5829157128019473
P58252	Elongation factor 2 [OS=Mus musculus]	126.048	cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes	plasma membrane;other membranes;cytosol;translational apparatus;other cell component	cytoskeletal activity;translation activity;nucleic acid binding activity;other molecular function	13629	ENSMUSG00000034994	Eef2	mmu:13629; P58252; Q544E4	Translation factors	Neutrophil degranulation; Protein methylation; Peptide chain elongation; Synthesis of diphthamide-EEF2	0.922179983282929	0.866546043492515	6414138.274151959	1.0566307796994643E7	2.9620591728864197E7	4859646.5618234025	1.3065706600835832E7	0.3063138071523588	-0.4004040637211755
Cont_P02538	Keratin, type II cytoskeletal 6A OS=Homo sapiens OX=9606 GN=KRT6A PE=1 SV=3	123.757	cell organization and biogenesis;stress response;other biological processes	cytosol;cytoskeleton	bone, tooth or skin structural activity;cytoskeletal activity	3853	ENSG00000205420	KRT6A	A4QPC1; hsa:3853; P02538; P48667; Q08AR4; Q6NT67; Q96CL4	Ectoderm differentiation; Ectoderm differentiation; Pancreatic cancer subtypes	Formation of the cornified envelope	0.792564971776066	0.709593139419252	4785085.111074816	3779160.7730984767	3044210.664784646	8485501.699692694	3982846.61307857	0.07573402481836149	0.826455374898488
P97298	Pigment epithelium-derived factor [OS=Mus musculus]	123.502	cell cycle OR cell proliferation;developmental processes;other biological processes	non-structural extracellular;extracellular matrix;other cell component	enzyme regulator activity	20317	ENSMUSG00000000753	Serpinf1	mmu:20317; O70629; O88691; P97298			0.00901230529014985	0.300753028734261	1.46490289953418E7	7.121805491857927E7	6.883649650666605E7	5921015.69252881	1.5757205380580032E7	-2.1762313456020066	-1.3068884569216235
Q70E20	Sushi, nidogen and EGF-like domain-containing protein 1 [OS=Mus musculus]	122.942	cell adhesion	non-structural extracellular;extracellular matrix	other molecular function	208777		Sned1	A6H6I3; mmu:208777; Q70E20; Q810H2; Q8BMD9			0.889058672589993	0.817293288705596	3293936.3484006864	6267209.5561869135	8981713.661313256	4995161.517920501	1.4223395042125002E7	1.1823707306994269	0.6007186512533814
P13020	Gelsolin [OS=Mus musculus]	122.934	cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes	non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component	cytoskeletal activity;other molecular function	227753	ENSMUSG00000026879	Gsn	mmu:227753; P13020; Q3UPB1; Q8R590	Regulation of actin cytoskeleton	Neutrophil degranulation; Caspase-mediated cleavage of cytoskeletal proteins	0.65414435708462	0.709593139419252	6438031.44422588	9825643.045518672	2.1865108079878632E7	1.1033925013460701E7	2.9144067496602204E7	1.5685785077495134	0.7772545527981521
Q61398	Procollagen C-endopeptidase enhancer 1 [OS=Mus musculus]	120.4	protein metabolism;other biological processes		enzyme regulator activity;other molecular function	18542	ENSMUSG00000029718	Pcolce	mmu:18542; O35113; Q61398	mRNA processing	Collagen biosynthesis and modifying enzymes; Crosslinking of collagen fibrils	0.133905327763598	0.0895861566882082	2.52047208020085E7	2.958750643636163E7	3.717663177971887E7	7672570.19904635	1.2538308810459368E7	-1.2386453468264698	-1.7159121278098002
P26039	Talin-1 [OS=Mus musculus]	118.226	cell adhesion;cell organization and biogenesis;signal transduction	plasma membrane;other membranes;cytosol;cytoskeleton;other cell component	signal transduction activity or receptor binding;cytoskeletal activity;other molecular function	21894	ENSMUSG00000028465	Tln1	A2AIM8; mmu:21894; P26039; Q8VEF0	Primary focal segmental glomerulosclerosis (FSGS); Integrin-mediated cell adhesion; Focal adhesion	Platelet degranulation ; MAP2K and MAPK activation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; Smooth Muscle Contraction; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	0.850917681937748	0.87222702623065	165904.24421521465	567933.664164035	2047443.5453512298	286851.2614141297	2291518.0404973766	2.0125093088074704	0.7899520679334946
Q8BPB5	EGF-containing fibulin-like extracellular matrix protein 1 [OS=Mus musculus]	117.738	protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes	extracellular matrix	signal transduction activity or receptor binding;kinase activity;other molecular function	216616	ENSMUSG00000020467	Efemp1	mmu:216616; Q6Y3N6; Q8BPB5			0.278244203695445	0.145805028390539	4441372.613318663	7007290.288389671	9374363.446007233	1370373.3251651835	3606517.1409647237	-0.9582503828225413	-1.6964366384968077
P09411	Phosphoglycerate kinase 1 [OS=Mus musculus]	116.462	protein metabolism;other metabolic processes;stress response;other biological processes	non-structural extracellular;other membranes;cytosol;mitochondrion;other cell component	kinase activity;other molecular function	18655	ENSMUSG00000062070	Pgk1	mmu:18655; P09411; Q3TPE6; Q3UKV8; Q5XJE7	Glycolysis and gluconeogenesis	Gluconeogenesis; Glycolysis	0.465126095372736	0.820281310709571	3210948.6178334034	3594147.655304653	7046094.17133664	4500077.619792943	1.4795712145397767E7	2.041457553634679	0.48695030706009684
P27773	Protein disulfide-isomerase A3 [OS=Mus musculus]	115.891	cell adhesion;cell organization and biogenesis;stress response;signal transduction;other biological processes	non-structural extracellular;other membranes;ER/Golgi;other cell component	nucleic acid binding activity;other molecular function	14827	ENSMUSG00000027248	Pdia3	mmu:14827; P27773; Q3TEI9; Q3TIL2; Q3UZK8; Q8C2F4; Q99LF6		ER-Phagosome pathway; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Calnexin/calreticulin cycle	0.850917681937748	0.881496352314601	5161827.016313557	6480316.532156386	1.845644105269933E7	7238345.98431998	1.5315044241817234E7	1.2408133459469528	0.48777827396885565
P10107	Annexin A1 [OS=Mus musculus]	115.566	cell organization and biogenesis;stress response;transport;signal transduction;other biological processes	non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component	enzyme regulator activity;other molecular function	16952	ENSMUSG00000024659	Anxa1	mmu:16952; P10107	Spinal cord injury; Prostaglandin synthesis and regulation	G alpha (q) signalling events; G alpha (i) signalling events; Formyl peptide receptors bind formyl peptides and many other ligands	0.954328834404239	0.529099828181544	1675870.316312303	6017153.19339518	1.1246783571413433E7	4211649.667813237	1.08370832078509E7	0.8488235161720351	1.3294749220803617
Cont_Q2KJF1	Alpha-1B-glycoprotein OS=Bos taurus OX=9913 GN=A1BG PE=1 SV=1	115.502	signal transduction	non-structural extracellular;plasma membrane;other membranes		518955		A1BG	bta:518955; Q2KJF1		Platelet degranulation ; Neutrophil degranulation	0.932231143665149	0.601376052147163	9820849.23751892	8859077.038578315	5863583.3120338395	6762503.63408608	1.0317459698123023E7	0.21985949488281362	-0.5382903197621131
Cont_Q3MHN5	Vitamin D-binding protein OS=Bos taurus OX=9913 GN=GC PE=2 SV=1	113.599	other metabolic processes;transport	non-structural extracellular;other cell component	transporter activity;cytoskeletal activity;other molecular function	530076		GC	bta:530076; Q3MHN5			0.946173787415917	0.570795727084329	1.5974245944817802E7	1.026921939097026E7	8132938.425379939	1.0785165311962552E7	1.4618596373270534E7	0.5094782752262966	-0.5666995412925446
P17742	Peptidyl-prolyl cis-trans isomerase A [OS=Mus musculus]	113.527	cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes	non-structural extracellular;cytosol;nucleus;other cell component	signal transduction activity or receptor binding;other molecular function	268373	ENSMUSG00000071866	Ppia	mmu:268373; P17742; Q9CWJ5; Q9R137		Neutrophil degranulation; Basigin interactions	0.946239447314336	0.937453377971347	1.0145464905716315E7	3.610988970082183E7	6.97111893668837E7	1.0696784170781441E7	4.607074026803666E7	0.3514567659376412	0.07634216032534753
Q69ZN7	Myoferlin [OS=Mus musculus]	112.647	cell organization and biogenesis;other metabolic processes;stress response;other biological processes	plasma membrane;other membranes;nucleus	other molecular function	226101	ENSMUSG00000048612	Myof	mmu:226101; Q69ZN7; Q7TMG0; Q80V33; Q8BU64; Q8BU70; Q8BUC1; Q8BVY6; Q8C0D1; Q8R3B4			0.816275429153737	0.609903091678244	322363.41862436634	911704.7850761963	2642353.10757036	1104935.9693987637	3065805.015040973	1.7496272919339693	1.7772028252973333
P26041	Moesin [OS=Mus musculus]	112.068	cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes	plasma membrane;other membranes;cytosol;cytoskeleton;other cell component	signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function	17698	ENSMUSG00000031207	Msn	B1AX70; mmu:17698; P26041; Q3UL28; Q8BSN4	Regulation of actin cytoskeleton	Recycling pathway of L1	0.910750689050232	0.97925982662951	9136364.2843242	1.7052591672350097E7	3.507274229077233E7	1.120013397828275E7	1.9030746620886367E7	0.15834114468472432	0.29382391022615884
P05064	Fructose-bisphosphate aldolase A [OS=Mus musculus]	112.015	cell organization and biogenesis;other metabolic processes;other biological processes	plasma membrane;other membranes;cytosol;cytoskeleton;other cell component	other molecular function	11674	ENSMUSG00000030695	Aldoa	mmu:11674; P05064	Glycolysis and gluconeogenesis	Platelet degranulation ; Neutrophil degranulation; Gluconeogenesis; Glycolysis	0.907383519445145	0.988377544628277	4319055.57861477	4893427.94836492	1.3571821307477335E7	4518789.603964283	1.0653934694757948E7	1.1224689803597754	0.0652205047103212
B2RQC6	Multifunctional protein CAD [OS=Mus musculus]	111.853	other metabolic processes;stress response;transport;developmental processes;other biological processes	cytosol;nucleus;other cell component	kinase activity;other molecular function	69719	ENSMUSG00000013629	Cad	B2RQC6; B7ZN27; mmu:69719	Mechanisms associated with pluripotency	Pyrimidine biosynthesis	0.340675523776301	0.798180783050573	448793.6641228067	957747.5456383955	3728337.7638301034	139659.55402474166	452794.3373622177	-1.0807895075821645	-1.6841380378584145
Q8BND5	Sulfhydryl oxidase 1 [OS=Mus musculus]	111.186	cell organization and biogenesis;other biological processes	non-structural extracellular;other membranes;ER/Golgi	other molecular function	104009	ENSMUSG00000033684	Qsox1	mmu:104009; Q3TDY9; Q3TE19; Q3TR29; Q3UEL4; Q8BND5; Q8K041; Q9DBL6		Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Neutrophil degranulation	0.203109767081086	0.331332346840573	3849451.1157268733	1.052758137572049E7	1.39599253643295E7	1818282.5759143168	5040172.36278756	-1.0626290505699043	-1.082076326435299