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| Q91ZX7 | Prolow-density lipoprotein receptor-related protein 1 [OS=Mus musculus] | 230.497 | 15 | 57 | 519 | 56 | 4545 | 504.4 | other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;other molecular function | 16971 | Lrp1 | mmu:16971; Q61291; Q91ZX7; Q920Y4 | Statin pathway; Wnt signaling pathway | Scavenging of heme from plasma; Retinoid metabolism and transport | 1.65082956259427E-17 | 0.0181625429641231 | 0.133639440745791 | 0.150830220548111 | 0.687557067265551 | 0.925871264502428 | 0.74148782464906 | 0.901098484497789 | 10237.2255539891 | 51104.3489937616 | 6875342.47952318 | 6944806.90573824 | 8247481.69257335 | 4299652.1243919 | 2953538.60705284 | 3392031.85738558 | 6405748.2654286 | 5854087.4911046 | 4914685.84613499 | 2044471.2247951 | 1705219.62694462 | 2981142.11204421 | ||
| Q61735 | Leukocyte surface antigen CD47 [OS=Mus musculus] | 15.208 | 15 | 4 | 11 | 4 | 303 | 33.1 | cell adhesion;stress response;developmental processes;other biological processes | non-structural extracellular;plasma membrane;other membranes;other cell component | other molecular function | 16423 | ENSMUSG00000055447 | Cd47 | mmu:16423; Q61735; Q921Z2 | Spinal cord injury | Neutrophil degranulation; Cell surface interactions at the vascular wall; Signal regulatory protein family interactions; Integrin cell surface interactions | 1.65082956259427E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.777389280685064 | 5.07936507936508E-17 | 5.0092807424594E-17 | 0.779071785728112 | 22294.8136117739 | 74464.0032664488 | 54394.6396516188 | 226303.487432309 | 220659.736153772 | 166285.386785101 | 55709.9434049051 | 35580.3767833261 | 118921.684369526 | |||||||
| D3YXK2 | Scaffold attachment factor B1 [OS=Mus musculus] | 49.566 | 15 | 8 | 31 | 8 | 937 | 105 | other metabolic processes;signal transduction;other biological processes | nucleus | nucleic acid binding activity;other molecular function | 224903 | ENSMUSG00000071054 | Safb | D3YXK2; mmu:224903 | SUMOylation of transcription cofactors | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 6.99442896935933E-17 | 5.07936507936508E-17 | 0.947768687612402 | 4.92607213887E-4 | 15393.7983475046 | 17239.7109999147 | 426655.78623829 | 370025.324731997 | 368892.151212 | 24759.1864972361 | 16568.3475218723 | ||||||||||
| P10404 | MLV-related proviral Env polyprotein [OS=Mus musculus] | 36.561 | 15 | 7 | 57 | 7 | 641 | 69.6 | plasma membrane;other membranes | other molecular function | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.2345984265382 | 0.722423519582044 | 0.666085392817333 | 0.925848639863437 | 565490.15323181 | 1094031.5100162 | 812812.264981893 | 553879.998281587 | 492643.551415468 | 443172.754726564 | 543517.389960944 | 554364.432327967 | 403550.864634056 | 73693.4988757822 | 140599.96745607 | 244870.889610433 | ||||||||||
| P11440 | Cyclin-dependent kinase 1 [OS=Mus musculus] | 10.473 | 14 | 4 | 13 | 2 | 297 | 34.1 | cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | cytoskeleton;mitochondrion;nucleus;other cell component | kinase activity;other molecular function | 12534 | ENSMUSG00000019942 | Cdk1 | mmu:12534; P11440; P70337; Q3TI12 | Hedgehog signaling pathway; Spinal cord injury; p53 signaling; G1 to S cell cycle control; Wnt signaling pathway | Nuclear Pore Complex (NPC) Disassembly; Cyclin A/B1/B2 associated events during G2/M transition; Ovarian tumor domain proteases; Condensation of Prophase Chromosomes; APC/C:Cdc20 mediated degradation of Cyclin B; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Phosphorylation of the APC/C; Anchoring of the basal body to the plasma membrane; PKR-mediated signaling; Resolution of Sister Chromatid Cohesion; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; AURKA Activation by TPX2; The role of GTSE1 in G2/M progression after G2 checkpoint; MAPK6/MAPK4 signaling; Initiation of Nuclear Envelope (NE) Reformation; Depolymerization of the Nuclear Lamina; Regulation of TP53 Degradation; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; MAPK3 (ERK1) activation; Phosphorylation of Emi1; Activation of NIMA Kinases NEK9, NEK6, NEK7; G2/M DNA replication checkpoint; Transcriptional regulation by RUNX2 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.831628912513977 | 0.749873305841414 | 0.977491813528386 | 0.989579506908047 | 103807.694021443 | 99378.5398481821 | 16012.3140540966 | 26023.6087943977 | 43519.5774043007 | 126675.635340405 | 102995.810269985 | 121884.073091066 | 29943.0914460917 | 22276.6949998305 | 19198.2857240785 | ||||
| Q66JS6 | Eukaryotic translation initiation factor 3 subunit J-B [OS=Mus musculus] | 11.41 | 14 | 4 | 40 | 4 | 263 | 29.5 | cell organization and biogenesis;protein metabolism;other metabolic processes | translational apparatus;other cell component | other molecular function | 100042807 | ENSMUSG00000043424 | Eif3j2 | mmu:100042807; Q66JS6; Q8BUW6 | L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.976873891151678 | 0.905995999887569 | 0.953448341575545 | 0.830251457557488 | 322005.688549835 | 259919.140503802 | 154459.443854785 | 108377.820258108 | 104925.033669946 | 154547.921648817 | 516171.4136426 | 504912.164447157 | 262772.599859334 | 121064.174676549 | 76225.8837741549 | 178202.325287152 | ||||
| P08030 | Adenine phosphoribosyltransferase [OS=Mus musculus] | 9.108 | 14 | 2 | 13 | 2 | 180 | 19.7 | other metabolic processes;other biological processes | cytosol;nucleus | other molecular function | 11821 | ENSMUSG00000006589 | Aprt | mmu:11821; P08030; Q564P4; Q61319; Q6PK77; Q9DCY3 | Purine metabolism | Neutrophil degranulation; Purine salvage | 1.65082956259427E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.920831575658121 | 5.07936507936508E-17 | 5.0092807424594E-17 | 0.80954066750699 | 60175.7361813812 | 70551.0423676772 | 47472.1579039534 | 131812.16628886 | 139717.3649093 | 134551.885141856 | 76046.0703819561 | 33683.3286530279 | 112436.951048548 | |||||||
| P70195 | Proteasome subunit beta type-7 [OS=Mus musculus] | 9.572 | 14 | 4 | 30 | 4 | 277 | 29.9 | protein metabolism;other metabolic processes | cytosol;nucleus;other cell component | other molecular function | 19177 | ENSMUSG00000026750 | Psmb7 | mmu:19177; O09084; P70195; Q542F7; Q9CZH4; Q9DCF7 | Proteasome degradation | Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Neddylation; FCERI mediated NF-kB activation; Downstream TCR signaling; Neutrophil degranulation; Activation of NF-kappaB in B cells; Asymmetric localization of PCP proteins; Degradation of AXIN; Hedgehog 'on' state; Ub-specific processing proteases; Regulation of RUNX3 expression and activity; Antigen processing: Ubiquitination & Proteasome degradation; Autodegradation of Cdh1 by Cdh1:APC/C; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Assembly of the pre-replicative complex; CDK-mediated phosphorylation and removal of Cdc6; MAPK6/MAPK4 signaling; UCH proteinases; Regulation of PTEN stability and activity; ABC-family proteins mediated transport; Regulation of RAS by GAPs; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Degradation of CDH1; Regulation of ornithine decarboxylase (ODC); Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF(Skp2)-mediated degradation of p27/p21; Degradation of beta-catenin by the destruction complex; Autodegradation of the E3 ubiquitin ligase COP1; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of DVL; Hedgehog ligand biogenesis; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; GLI3 is processed to GLI3R by the proteasome; NIK-->noncanonical NF-kB signaling; Orc1 removal from chromatin; G2/M Checkpoints; Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Proteasome assembly; Degradation of CRY and PER proteins; ER-Phagosome pathway; Antigen processing: Ub, ATP-independent proteasomal degradation | 0.867446002763348 | 0.458134441049542 | 0.647667629083265 | 0.832435218786368 | 0.944154202827561 | 0.445511199818334 | 0.866766165039268 | 0.750443869513654 | 7964.69105165371 | 159833.006933972 | 221964.588716987 | 85862.4338327778 | 173657.23037539 | 123699.368664507 | 371277.122504089 | 613500.624224884 | 531305.353137595 | 303983.936676822 | 232125.424412302 | 246498.261382693 | 104159.725662868 | ||
| O08663 | Methionine aminopeptidase 2 [OS=Mus musculus] | 18.752 | 14 | 6 | 27 | 6 | 478 | 52.9 | protein metabolism;other metabolic processes;other biological processes | plasma membrane;other membranes;cytosol;other cell component | other molecular function | 56307 | ENSMUSG00000036112 | Metap2 | mmu:56307; O08663 | Inactivation, recovery and regulation of the phototransduction cascade | 0.487876461503982 | 0.728005987373569 | 0.533837446822064 | 0.0186303617793598 | 0.938859506774495 | 0.926252140544192 | 0.00109494908164684 | 0.269724607564787 | 61958.054025809 | 47092.2920518779 | 59691.6872353124 | 155508.531237932 | 234367.162745688 | 58252.33282857 | 129226.827527334 | 262944.042359706 | 359138.558599007 | 189091.272015793 | 9221.83531565028 | 25133.4242505227 | ||||
| O35188 | Fractalkine [OS=Mus musculus] | 28.718 | 14 | 5 | 77 | 5 | 395 | 42.1 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular;plasma membrane;other membranes;other cell component | signal transduction activity or receptor binding | 20312 | ENSMUSG00000031778 | Cx3cl1 | mmu:20312; O35188; O35933; Q91V44 | Chemokine signaling pathway | G alpha (i) signalling events; Chemokine receptors bind chemokines | 0.266432638203527 | 0.507952738758732 | 0.639608079726835 | 0.753448703421541 | 0.406478682625964 | 0.634088329627404 | 0.844628353406227 | 0.99316924523492 | 22673.8945272009 | 30227.6723379273 | 19464.6898673634 | 2598765.30835276 | 2651586.83061435 | 4329260.81968736 | 1109110.4155612 | 984120.783081298 | 887182.156583255 | 2213713.7921126 | 2253795.55344493 | 1664714.71609425 | 1004980.36585156 | 621809.429148208 | 1340762.91716607 |
| Q8VDM4 | 26S proteasome non-ATPase regulatory subunit 2 [OS=Mus musculus] | 36.037 | 14 | 11 | 62 | 11 | 908 | 100.1 | other biological processes | other cell component | enzyme regulator activity | 21762 | ENSMUSG00000006998 | Psmd2 | mmu:21762; Q8VDM4 | Proteasome degradation | Neutrophil degranulation; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Neddylation; Asymmetric localization of PCP proteins; Degradation of AXIN; Hedgehog 'on' state; Ub-specific processing proteases; Regulation of RUNX3 expression and activity; Antigen processing: Ubiquitination & Proteasome degradation; Autodegradation of Cdh1 by Cdh1:APC/C; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; Assembly of the pre-replicative complex; CDK-mediated phosphorylation and removal of Cdc6; The role of GTSE1 in G2/M progression after G2 checkpoint; MAPK6/MAPK4 signaling; UCH proteinases; Regulation of PTEN stability and activity; ABC-family proteins mediated transport; Regulation of RAS by GAPs; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Degradation of CDH1; Regulation of ornithine decarboxylase (ODC); Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF(Skp2)-mediated degradation of p27/p21; Degradation of beta-catenin by the destruction complex; Autodegradation of the E3 ubiquitin ligase COP1; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of DVL; Hedgehog ligand biogenesis; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; GLI3 is processed to GLI3R by the proteasome; NIK-->noncanonical NF-kB signaling; Orc1 removal from chromatin; G2/M Checkpoints; Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Proteasome assembly; Degradation of CRY and PER proteins | 0.0217341835979596 | 3.43576891704979E-4 | 0.0457463742188904 | 0.00770473905982669 | 0.964629994744883 | 0.764791307960872 | 0.965092178827075 | 0.932278196428948 | 238571.324800066 | 214302.421087303 | 338610.98899305 | 162987.256418827 | 43001.847305247 | 76338.4511117734 | 123402.287183364 | 636500.560032057 | 571158.115126111 | 452970.76326951 | 97306.1872254325 | 33146.3956684098 | 145507.845823676 | ||
| Q61362 | Chitinase-3-like protein 1 [OS=Mus musculus] | 6.474 | 14 | 4 | 7 | 4 | 389 | 43.9 | other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular;ER/Golgi;other cell component | other molecular function | 12654 | ENSMUSG00000064246 | Chi3l1 | B0FEU7; D3Z2P2; mmu:12654; Q3U291; Q4FJW9; Q61362; Q8BKL8; Q99J84 | Neutrophil degranulation | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 0.160612027998472 | 0.285666077089195 | 5.0092807424594E-17 | 5.71658986175115E-17 | 38567.6567890826 | 88343.7976035462 | 198215.412179342 | 5607.55404999668 | 4282.12766780072 | ||||||||||||
| Q00519 | Xanthine dehydrogenase/oxidase [OS=Mus musculus] | 51.714 | 14 | 16 | 60 | 16 | 1335 | 146.5 | cell organization and biogenesis;other metabolic processes;transport;other biological processes | non-structural extracellular;cytosol;ER/Golgi;other cytoplasmic organelle | other molecular function | 22436 | ENSMUSG00000024066 | Xdh | E9QLM9; mmu:22436; Q00519 | Selenium micronutrient network; Folic acid network; Purine metabolism | Purine catabolism; Butyrophilin (BTN) family interactions; Azathioprine ADME | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.0138748109681077 | 0.884960226310414 | 0.258098996510592 | 0.781340503802277 | 99745.2932364919 | 74167.1869153959 | 67299.004313408 | 43493.9274627531 | 38599.0481697965 | 1683173.53057294 | 1420327.30646394 | 1300153.60132338 | 386617.535418133 | 200684.960137196 | 539290.495595296 | ||||
| Q60668 | Heterogeneous nuclear ribonucleoprotein D0 [OS=Mus musculus] | 17.818 | 14 | 4 | 48 | 3 | 355 | 38.3 | developmental processes;other biological processes | cytosol;nucleus;other cell component | nucleic acid binding activity;other molecular function | 11991 | ENSMUSG00000000568 | Hnrnpd | mmu:11991; Q60667; Q60668; Q80ZJ0; Q91X94 | mRNA processing | mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA; AUF1 (hnRNP D0) binds and destabilizes mRNA | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.606549315086283 | 0.917632081652764 | 0.886209862305834 | 0.0950761391992693 | 467150.530657345 | 511408.541810146 | 314373.191646108 | 253003.175082797 | 230119.169498786 | 394155.861674114 | 1549056.94541892 | 1336976.87469143 | 1181618.57027123 | 234226.128140761 | 136958.475694925 | 321210.858469823 | |||
| P28656 | Nucleosome assembly protein 1-like 1 [OS=Mus musculus] | 27.215 | 14 | 4 | 33 | 3 | 391 | 45.3 | cell organization and biogenesis;developmental processes;other biological processes | nucleus;other cell component | other molecular function | 53605 | ENSMUSG00000058799 | Nap1l1 | mmu:53605; P28656; Q3UL14 | 0.8353930748656 | 0.975410229624244 | 0.633611399614003 | 0.854305439376382 | 0.416761072145714 | 0.74388258656266 | 0.725153998443568 | 22518.5541178004 | 213980.159800206 | 260131.536373293 | 51581.181878757 | 22745.1031220577 | 43994.2910511152 | 34450.7796454099 | 223178.126547608 | 238223.456985414 | 306934.032621539 | 52836.8711312552 | 17244.5740119043 | 40484.2727964735 | |||||
| Q921M3 | Splicing factor 3B subunit 3 [OS=Mus musculus] | 54.899 | 14 | 16 | 104 | 16 | 1217 | 135.5 | RNA metabolism OR transcription;other metabolic processes;other biological processes | nucleus;other cell component | nucleic acid binding activity;other molecular function | 101943 | ENSMUSG00000033732 | Sf3b3 | mmu:101943; Q3UGI3; Q6ZQL0; Q8BUD9; Q8K2J8; Q921M3 | mRNA processing | mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.944154202827561 | 0.989650270450024 | 0.900765223402233 | 0.686547064791248 | 554137.757439399 | 525066.192186938 | 248242.574475954 | 153291.619539348 | 163093.752726662 | 390004.780993501 | 1316981.72703489 | 1063975.06373625 | 739246.803277531 | 182268.466053258 | 96856.5320638787 | 290082.147244392 | |||
| Q99LP6 | GrpE protein homolog 1, mitochondrial [OS=Mus musculus] | 8.748 | 14 | 3 | 13 | 3 | 217 | 24.3 | protein metabolism;other metabolic processes | mitochondrion;nucleus | other molecular function | 17713 | ENSMUSG00000029198 | Grpel1 | mmu:17713; Q3TSZ3; Q99LP6 | 1.65082956259427E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.830676695521175 | 5.07936507936508E-17 | 5.0092807424594E-17 | 0.368699735932311 | 11038.9480391043 | 27268.917977291 | 50696.6310872655 | 46294.5725810243 | 70526.0559872336 | 7811.50241896404 | ||||||||||||
| Q9JI48 | Placenta-specific gene 8 protein [OS=Mus musculus] | 17.136 | 14 | 2 | 24 | 2 | 112 | 12.3 | RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes | nucleus | other molecular function | 231507 | ENSMUSG00000029322 | Plac8 | mmu:231507; Q9JI48 | Neutrophil degranulation | ||||||||||||||||||||||||
| Q9JJI8 | Large ribosomal subunit protein eL38 [OS=Mus musculus] | 4.036 | 14 | 1 | 4 | 1 | 70 | 8.2 | cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes | cytosol;translational apparatus;other cell component | other molecular function | 67671 | ENSMUSG00000057322 | Rpl38 | mmu:67671; Q9JJI8 | Cytoplasmic ribosomal proteins; mRNA processing | L13a-mediated translational silencing of Ceruloplasmin expression; SRP-dependent cotranslational protein targeting to membrane; Major pathway of rRNA processing in the nucleolus and cytosol; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 1.65082956259427E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.403894201414054 | 5.07936507936508E-17 | 5.0092807424594E-17 | 0.823633113924625 | 19725.5430386913 | 74817.4638166992 | 69361.0033277799 | 76241.2283495303 | 26372.693289078 | |||||||||||
| O70591 | Prefoldin subunit 2 [OS=Mus musculus] | 7.398 | 14 | 2 | 9 | 2 | 154 | 16.5 | protein metabolism;other metabolic processes;other biological processes | cytosol;mitochondrion;nucleus;other cell component | other molecular function | 18637 | ENSMUSG00000006412 | Pfdn2 | mmu:18637; O70591; Q8R0H2 | 1.65082956259427E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.957324015670425 | 5.07936507936508E-17 | 5.0092807424594E-17 | 0.809503222445875 | 36359.6554283158 | 67005.3972553793 | 81464.3091693307 | 128532.207424722 | 100405.098848861 | 91897.3343916583 | 17543.6209787871 | |||||||||||
| Q61414 | Keratin, type I cytoskeletal 15 [OS=Mus musculus] | 30.512 | 14 | 9 | 270 | 2 | 452 | 49.1 | cytoskeleton | other molecular function | 16665 | Krt15 | mmu:16665; Q61414; Q6PEQ0 | Formation of the cornified envelope | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.916864373365557 | 0.50709848833181 | 0.105758377208028 | 2.88344748540139E-4 | 34030.6278544352 | 37754.3305354821 | 32433.1028026139 | 33761.1809754994 | 41039.7468594889 | 54778.7478913336 | 30329.442750687 | 324230.183777739 | 58140.6721221674 | |||||||||
| Q9D892 | Inosine triphosphate pyrophosphatase [OS=Mus musculus] | 7.551 | 14 | 2 | 4 | 2 | 198 | 21.9 | cell organization and biogenesis;other metabolic processes | cytosol;nucleus | other molecular function | 16434 | ENSMUSG00000074797 | Itpa | mmu:16434; Q8R0Q8; Q9D892 | Purine metabolism | Purine catabolism; Ribavirin ADME | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.85271451854395 | 0.787830791029295 | 0.941992570999798 | 0.950507099097121 | 21988.9040206466 | 18328.7067074407 | 73128.5314155551 | 36992.7136205413 | 45735.2903165139 | 23109.3140060857 | |||||||||
| P07141 | Macrophage colony-stimulating factor 1 [OS=Mus musculus] | 21.962 | 14 | 6 | 34 | 6 | 552 | 60.6 | cell cycle OR cell proliferation;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular;plasma membrane;other membranes;nucleus;other cell component | signal transduction activity or receptor binding;other molecular function | 12977 | ENSMUSG00000014599 | Csf1 | mmu:12977; P07141; Q3U395; Q8R3C8 | Cytokines and inflammatory response; Focal adhesion: PI3K-Akt-mTOR signaling pathway; IL26 signaling | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Transcriptional and post-translational regulation of MITF-M expression and activity; Other interleukin signaling | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.47444198648237 | 0.972868731003358 | 0.604942795415824 | 0.541202479085838 | 3919.3022284161 | 430614.490485726 | 862790.798449294 | 971966.839411481 | 176024.463934792 | 227845.404151967 | 162631.807971827 | 663762.600147891 | 701218.066669344 | 556989.005415662 | 200529.612111431 | 314377.226872723 | 204315.54392019 | ||
| Q8VEK3 | Heterogeneous nuclear ribonucleoprotein U [OS=Mus musculus] | 45.223 | 14 | 9 | 69 | 9 | 800 | 87.9 | cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes | cytosol;cytoskeleton;nucleus;other cell component | cytoskeletal activity;nucleic acid binding activity;other molecular function | 51810 | ENSMUSG00000039630 | Hnrnpu | G3XA10; mmu:51810; Q8VEK3; Q9R205 | Mechanisms associated with pluripotency; mRNA processing | mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.371817234249266 | 0.930391929253067 | 0.597118994486343 | 0.422736226105005 | 367466.827797769 | 455121.278717369 | 454633.97850924 | 31576.8007228856 | 22324.98576567 | 48407.4302696471 | 2058731.93870388 | 1876997.32226139 | 1645672.53353067 | 391453.064921064 | 222826.758853356 | 414621.806768926 | |||
| Q9CQU0 | Thioredoxin domain-containing protein 12 [OS=Mus musculus] | 7.166 | 14 | 2 | 14 | 2 | 170 | 19 | other biological processes | ER/Golgi | other molecular function | 66073 | ENSMUSG00000028567 | Txndc12 | mmu:66073; Q53YN1; Q9CQU0 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.947365742925239 | 0.803942126547791 | 0.815615004446116 | 0.960067393782086 | 46445.9372781815 | 45687.2210470442 | 115630.439721802 | 24104.4631233795 | 16101.8796920684 | 173717.304148464 | 178646.287016638 | 138643.018476924 | 39242.124862102 | ||||||||
| Q8CI94 | Glycogen phosphorylase, brain form [OS=Mus musculus] | 40.416 | 14 | 10 | 68 | 10 | 843 | 96.7 | other metabolic processes | other cell component | other molecular function | 110078 | ENSMUSG00000033059 | Pygb | mmu:110078; Q8CI94; Q8K283 | Glycogen metabolism | Neutrophil degranulation | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.976873891151678 | 0.972868731003358 | 0.993672648596764 | 0.819844267712751 | 302444.924616615 | 341214.009676539 | 233327.298665776 | 99596.9220324667 | 39704.3603003118 | 216239.577324026 | 750529.449164548 | 619769.970153928 | 580326.854172933 | 94442.9211543934 | 78984.1099732056 | 214792.167290488 | |||
| Q99JY8 | Phospholipid phosphatase 3 [OS=Mus musculus] | 11.427 | 14 | 4 | 20 | 4 | 312 | 35.2 | cell adhesion;other metabolic processes;transport;developmental processes;signal transduction;other biological processes | plasma membrane;other membranes;ER/Golgi;other cell component | signal transduction activity or receptor binding;other molecular function | 67916 | ENSMUSG00000028517 | Plpp3 | mmu:67916; Q3TVM4; Q3TXR7; Q8BTB7; Q99JY8 | Triacylglyceride synthesis; Sphingolipid metabolism overview; Sphingolipid metabolism (integrated pathway) | Sphingolipid catabolism | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.873609880131656 | 0.835251378529265 | 0.799483493038835 | 0.938282411159324 | 74387.42775583 | 95768.5959594354 | 100515.793772984 | 32818.4990194083 | 13875.0160606276 | 17990.2149805288 | 505024.157113874 | 464331.114178593 | 361715.327619697 | 208322.11921108 | 42534.7000555568 | 342696.979348808 | |||
| Q78PY7 | Staphylococcal nuclease domain-containing protein 1 [OS=Mus musculus] | 30.18 | 14 | 10 | 39 | 10 | 910 | 102 | RNA metabolism OR transcription;other metabolic processes;other biological processes | cytosol;nucleus;other cell component | nucleic acid binding activity;other molecular function | 56463 | ENSMUSG00000001424 | Snd1 | mmu:56463; Q3TT46; Q78PY7; Q922L5; Q9R0S1 | 0.976049623855779 | 0.796467665762937 | 0.462464108170116 | 0.907259863842687 | 0.672020864625319 | 0.384794804052606 | 0.961396519502261 | 0.999950801685853 | 16257.5069148024 | 195049.228004712 | 226600.202204068 | 20681.5501858268 | 77511.8441295746 | 125458.000833176 | 354656.573889071 | 884372.426241608 | 830766.421159026 | 602857.026066497 | 324067.968999159 | 83069.4035183691 | 336185.566356938 | ||||
| Q8K003 | Translation machinery-associated protein 7 [OS=Mus musculus] | 2.532 | 14 | 1 | 18 | 1 | 64 | 7.1 | 66167 | ENSMUSG00000091537 | Tma7 | mmu:66167; Q8K003 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.861004103240721 | 0.880940844456856 | 0.975873825035145 | 0.869792271407368 | 342651.593499554 | 311940.276336519 | 513604.724123459 | 173367.095708436 | 84075.6223617382 | 254648.240150038 | 525839.164588389 | 528174.498115483 | 258286.298220379 | 201453.066393861 | 131191.664278339 | 252168.629468461 | ||||||||
| O08585 | Clathrin light chain A [OS=Mus musculus] | 7.291 | 14 | 4 | 52 | 4 | 235 | 25.6 | transport;other biological processes | plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cell component | other molecular function | Clta | O08585 | MHC class II antigen presentation; Recycling pathway of L1; Cargo recognition for clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis; LDL clearance; Retrograde neurotrophin signalling; Formation of annular gap junctions; Lysosome Vesicle Biogenesis; WNT5A-dependent internalization of FZD4; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.946239447314336 | 0.990351741137916 | 0.93482524409719 | 0.788152312808629 | 740856.384280419 | 812334.694667415 | 555969.719610727 | 471120.351817991 | 316867.059771909 | 477072.581191441 | 1140295.98719963 | 1100031.53153547 | 662966.34286154 | 498464.778400624 | 224869.573852642 | 636316.904122107 | ||||||
| O35658 | Complement component 1 Q subcomponent-binding protein, mitochondrial [OS=Mus musculus] | 17.284 | 14 | 3 | 29 | 3 | 278 | 31 | cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes | non-structural extracellular;plasma membrane;other membranes;mitochondrion;nucleus;other cell component | signal transduction activity or receptor binding;enzyme regulator activity;translation activity;nucleic acid binding activity;other molecular function | C1qbp | O35658 | RHOA GTPase cycle; RHOC GTPase cycle; Intrinsic Pathway of Fibrin Clot Formation | 0.976049623855779 | 0.782206664326601 | 0.619345403494574 | 0.971489814526882 | 0.889097120198355 | 0.871988363152002 | 0.852443371895491 | 0.809503222445875 | 16688.4245986709 | 270316.588149926 | 318330.17757314 | 170476.12222939 | 70752.1062725203 | 72063.6371021457 | 78584.2750940511 | 437580.446462218 | 429926.502745417 | 408318.559716858 | 151621.543348639 | 49864.5950522499 | 242412.934501371 | |||||
| Q921F2 | TAR DNA-binding protein 43 [OS=Mus musculus] | 7.613 | 14 | 3 | 6 | 3 | 414 | 44.5 | cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes | mitochondrion;nucleus;other cell component | nucleic acid binding activity;other molecular function | 230908 | ENSMUSG00000041459 | Tardbp | mmu:230908; Q3U591; Q3V0E7; Q921F2 | mRNA processing | 1.50457038391225E-17 | 1.70336894001643E-17 | 6.99442896935933E-17 | 5.0092807424594E-17 | 0.903630382640696 | 173856.651708231 | 144962.528755273 | 142847.29645678 | 54073.4450131708 | 22271.9003144613 | 60689.8399495952 | |||||||||||||
| P28667 | MARCKS-related protein [OS=Mus musculus] | 10.604 | 14 | 2 | 22 | 2 | 200 | 20.2 | cell cycle OR cell proliferation;other biological processes | plasma membrane;other membranes;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 17357 | ENSMUSG00000047945 | Marcksl1 | mmu:17357; P28667; Q3TEZ4; Q91W07 | 1.65082956259427E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.979628232635575 | 5.07936507936508E-17 | 5.0092807424594E-17 | 0.953305976192702 | 60847.6228182191 | 37031.8265614775 | 90981.6289287175 | 147399.370163272 | 150659.158493768 | 109022.95301552 | 68497.7233077464 | 26758.7658062641 | ||||||||||
| Q9D1M0 | Protein SEC13 homolog [OS=Mus musculus] | 15.249 | 14 | 3 | 39 | 3 | 322 | 35.5 | cell organization and biogenesis;transport;other biological processes | other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component | other molecular function | 110379 | ENSMUSG00000030298 | Sec13 | mmu:110379; Q99M12; Q9D1M0; Q9D712 | MHC class II antigen presentation; Regulation of Glucokinase by Glucokinase Regulatory Protein; Amino acids regulate mTORC1; Regulation of HSF1-mediated heat shock response; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; Transcriptional regulation by small RNAs; Postmitotic nuclear pore complex (NPC) reformation; Separation of Sister Chromatids; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; COPII-mediated vesicle transport | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.957324015670425 | 0.877818946381645 | 0.758419323505603 | 0.508243918164012 | 197730.852750481 | 190573.741336353 | 192097.382591157 | 87833.3312129596 | 94209.6710927081 | 159873.585903059 | 409680.146693311 | 373267.470821825 | 268136.992078613 | 83114.2422227617 | 50575.823463244 | 93281.2914414936 | ||||
| Q99NB9 | Splicing factor 3B subunit 1 [OS=Mus musculus] | 36.432 | 14 | 12 | 24 | 12 | 1304 | 145.7 | cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes | nucleus;other cell component | nucleic acid binding activity;other molecular function | Sf3b1 | Q99NB9; Q9CSK5 | mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; B-WICH complex positively regulates rRNA expression | 0.575934278119586 | 0.48770991796071 | 0.305470800180684 | 0.976515248917187 | 0.904745716320523 | 0.197363944696333 | 3492.84196909084 | 23415.9307863747 | 61221.5972091154 | 44905.1619067822 | 4724.33387393796 | 6667.42696469231 | 401492.892182986 | 343763.024548638 | 193689.150930864 | 32889.2315275411 | 44728.3673049442 | 28503.5775384088 | ||||||||
| P70428 | Exostosin-2 [OS=Mus musculus] | 26.784 | 14 | 9 | 48 | 9 | 718 | 82 | protein metabolism;other metabolic processes;transport;developmental processes;other biological processes | non-structural extracellular;other membranes;ER/Golgi;other cell component | other molecular function | 14043 | ENSMUSG00000027198 | Ext2 | mmu:14043; P70395; P70428; Q3TPI7; Q923D6 | HS-GAG biosynthesis | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.312871703691533 | 0.767326422376928 | 0.438159803535847 | 0.965550454405477 | 682526.512483994 | 796792.869318289 | 627336.036498074 | 275792.332966542 | 135128.081054908 | 293838.392268786 | 424088.447368226 | 408035.035529463 | 232699.958152909 | 38967.0629577441 | 94720.0845734801 | |||||
| P00375 | Dihydrofolate reductase [OS=Mus musculus] | 4.612 | 14 | 2 | 8 | 2 | 187 | 21.6 | other metabolic processes;other biological processes | cytosol;mitochondrion;nucleus;other cell component | nucleic acid binding activity;other molecular function | 13361 | ENSMUSG00000021707 | Dhfr | mmu:13361; P00375; P70693; Q61485; Q61487; Q61579 | One-carbon metabolism and related pathways; One-carbon metabolism | Metabolism of folate and pterines | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.964629994744883 | 0.736623488960899 | 0.954263828585988 | 0.943678408143527 | 142802.223513602 | 127867.646755698 | 30988.1133487399 | 9018.50761305569 | 17904.0718310161 | 195051.17283287 | 252488.677512596 | 174245.749996984 | 9887.18147784972 | 153759.112890765 | |||||
| Q8R3Q6 | Protein MIX23 [OS=Mus musculus] | 5.41 | 14 | 2 | 9 | 2 | 144 | 16.7 | mitochondrion | 381045 | ENSMUSG00000075229 | Mix23 | mmu:381045; Q3UXM5; Q8R3Q6 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.957604068267166 | 0.905995999887569 | 0.661765596176351 | 0.292692675177549 | 26290.6535896272 | 29426.6465440792 | 37375.5421809021 | 15114.472386458 | 11924.3479130111 | 22541.3484050142 | 50522.2738808475 | 108107.713944243 | 45600.0694648851 | 6287.7861047589 | 17486.3508849132 | ||||||||
| P49442 | Inositol polyphosphate 1-phosphatase [OS=Mus musculus] | 12.714 | 14 | 4 | 18 | 4 | 396 | 43.3 | other metabolic processes | other molecular function | 16329 | ENSMUSG00000026102 | Inpp1 | mmu:16329; P49442; Q8R3L1 | Synthesis of IP2, IP, and Ins in the cytosol | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.998719389228602 | 0.488334133489065 | 0.877696436885309 | 0.953305976192702 | 50463.7558769926 | 69366.8508446433 | 75902.2606329452 | 9089.84674521265 | 104510.841868651 | 117777.586602841 | 129440.122875528 | 25898.9181948516 | 7933.04470367271 | 23574.6301211501 | |||||||
| P09535 | Insulin-like growth factor 2 [OS=Mus musculus] | 5.377 | 14 | 2 | 9 | 2 | 180 | 20 | cell cycle OR cell proliferation;other metabolic processes;developmental processes;signal transduction;other biological processes | non-structural extracellular | signal transduction activity or receptor binding;enzyme regulator activity | 16002 | ENSMUSG00000048583 | Igf2 | E9QLW5; mmu:16002; P09535 | Hedgehog signaling pathway; Apoptosis; Endochondral ossification | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Platelet degranulation ; Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R); IRS-related events triggered by IGF1R; SHC-related events triggered by IGF1R | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.1742696943566 | 0.266427566151349 | 0.388111386240804 | 0.0517368437289786 | 98395.7522736922 | 69054.9379670751 | 67016.4350638636 | 116817.806986939 | 126449.231037058 | 74205.7727354242 | 67705.0101700829 | 28265.7346921184 | 32511.6190775334 | 57632.5043000995 | |||||
| P0DOV1 | Interferon-activable protein 211 [OS=Mus musculus] | 17.046 | 14 | 5 | 31 | 2 | 425 | 46.9 | other biological processes | nucleus | 381308 | ENSMUSG00000026536 | Ifi211 | B7ZNS3; mmu:381308; P0DOV1; P15092; Q08619; Q3TM07; Q3U776; Q3U7F4; Q3U7K5; Q3UCH9; Q8C4X3; Q921V9 | Neutrophil degranulation | 1.50457038391225E-17 | 6.99442896935933E-17 | 5.71658986175115E-17 | 24315.1554714643 | 19142.7320619697 | ||||||||||||||||||||
| Q9DD18 | D-aminoacyl-tRNA deacylase 1 [OS=Mus musculus] | 6.699 | 14 | 2 | 3 | 2 | 209 | 23.4 | DNA metabolism;RNA metabolism OR transcription;other metabolic processes | nucleus;other cell component | nucleic acid binding activity;other molecular function | 66044 | ENSMUSG00000027430 | Dtd1 | A2ANA2; mmu:66044; Q3TY44; Q9CRE8; Q9CYL0; Q9D013; Q9D1G4; Q9DD18 | 1.50457038391225E-17 | 6.99442896935933E-17 | 5.71658986175115E-17 | 34506.8161207034 | |||||||||||||||||||||
| Q06335 | Amyloid beta precursor like protein 2 [OS=Mus musculus] | 25.334 | 14 | 9 | 71 | 8 | 707 | 80.4 | cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes | plasma membrane;other membranes;nucleus;other cell component | nucleic acid binding activity;other molecular function | 11804 | ENSMUSG00000031996 | Aplp2 | mmu:11804; Q06335; Q80US7 | Splicing factor NOVA regulated synaptic proteins | Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.816275429153737 | 0.866278047484845 | 0.974586536730103 | 0.684917106202847 | 438887.412331211 | 650249.237402316 | 547283.202013109 | 260681.782280931 | 175207.637128635 | 155579.655819713 | 669181.915267225 | 598185.438218512 | 495937.493478582 | 187747.735275665 | 65475.033701907 | 338151.332219261 | |||
| Cont_P00760 | Serine protease 1 OS=Bos taurus OX=9913 GN=PRSS1 PE=1 SV=3 | 5.277 | 14 | 2 | 126 | 1 | 246 | 25.8 | protein metabolism;other biological processes | non-structural extracellular;other cell component | other molecular function | 615026; 780933 | ENSBTAG00000060741; ENSBTAG00000067483 | PRSS1 | A6H6Y3; bta:615026; bta:780933; P00760 | 0.88124519152506 | 0.691968785462496 | 0.880379766732388 | 0.218579549144725 | 0.894035482546951 | 0.877818946381645 | 0.273184844111018 | 0.622880861621114 | 17426.8977336322 | 8651.52401014626 | 21137.0548338192 | 15628.1712934481 | 11172.1892975525 | 16470.2314898468 | 23258.3902847312 | 6725.87679578665 | |||||||||
| O35643 | AP-1 complex subunit beta-1 [OS=Mus musculus] | 31.593 | 14 | 13 | 74 | 3 | 943 | 103.9 | cell organization and biogenesis;transport;developmental processes | other membranes;cytosol;ER/Golgi;other cytoplasmic organelle | other molecular function | 11764 | ENSMUSG00000009090 | Ap1b1 | mmu:11764; O35643; Q3TXG4; Q922E2 | MHC class II antigen presentation; Golgi Associated Vesicle Biogenesis; Lysosome Vesicle Biogenesis | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.42706865755464 | 0.932655333085038 | 0.841561511546474 | 0.448481014492597 | 39290.7821781639 | 20916.0859916264 | 270045.825067166 | 156844.11559153 | 166005.277113062 | 34855.4481444787 | 28974.9960698101 | 32703.6197019034 | ||||||||
| P58871 | 182 kDa tankyrase-1-binding protein [OS=Mus musculus] | 53.606 | 14 | 17 | 57 | 17 | 1720 | 181.7 | DNA metabolism;other metabolic processes;stress response;other biological processes | cytosol;cytoskeleton;nucleus;other cell component | enzyme regulator activity;other molecular function | 228140 | ENSMUSG00000033955 | Tnks1bp1 | A2BH84; mmu:228140; P58871; Q6ZPI8 | Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain | 0.69953611130999 | 0.947627746595709 | 0.655383946448376 | 0.936542909613889 | 0.990459928977729 | 0.0182700421039277 | 0.886209862305834 | 0.453674861497639 | 313210.088324811 | 88898.4552364454 | 229323.353890783 | 371989.061329589 | 473472.28553572 | 402315.757004238 | 55070.4289776724 | 98671.2171526433 | 127949.354726459 | 874629.76170503 | 1001519.96530303 | 553556.536882255 | 577771.363234713 | 214428.771427911 | 558191.958320913 | |
| O89086 | RNA-binding protein 3 [OS=Mus musculus] | 11.721 | 14 | 2 | 34 | 2 | 153 | 16.6 | protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes | nucleus;other cell component | translation activity;nucleic acid binding activity | 19652 | ENSMUSG00000031167 | Rbm3 | mmu:19652; O89086 | mRNA processing | 1.65082956259427E-17 | 0.815163167608252 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.964629994744883 | 0.10583665524204 | 0.408262797375667 | 0.922371057250263 | 6578.50333309036 | 4787.78883008341 | 652450.961255203 | 479877.130486408 | 181360.962258306 | 51746.3478752743 | 86265.1197724962 | 65395.860876935 | 863205.577600611 | 785611.168687137 | 463814.413774143 | 242218.925742032 | 216896.758561701 | 378206.533058937 | ||
| P61327 | Protein mago nashi homolog [OS=Mus musculus] | 6.269 | 14 | 2 | 27 | 2 | 146 | 17.2 | RNA metabolism OR transcription;other metabolic processes;transport;other biological processes | cytosol;nucleus | nucleic acid binding activity | 17149 | ENSMUSG00000028609 | Magoh | A2A8E0; mmu:17149; O35169; P50606; P61327 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.922179983282929 | 0.941920360687835 | 0.92561336129553 | 0.622880861621114 | 5306537.05790985 | 5785217.67223623 | 5653302.21554429 | 2359227.71741652 | 2359185.28638024 | 3238543.10132928 | 5988704.55393281 | 6877657.94192549 | 4694556.74491765 | 3164565.25652211 | 3059731.61932354 | 5542291.34830919 | ||||
| P63089 | Pleiotrophin [OS=Mus musculus] | 7.076 | 14 | 1 | 9 | 1 | 168 | 18.9 | cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cell component | signal transduction activity or receptor binding;enzyme regulator activity;other molecular function | 19242 | ENSMUSG00000029838 | Ptn | mmu:19242; P20935; P63089 | MDK and PTN in ALK signaling; Signaling by ALK | 1.65082956259427E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.916283277860523 | 5.07936507936508E-17 | 5.0092807424594E-17 | 0.935117505923616 | 30607.23678618 | 45255.8802031232 | 61812.2874095725 | 51794.5056795959 | 35564.0091531662 | 98825.472711658 | 19882.8518528272 | 25008.5131862866 | |||||||||
| Q9JHU4 | Cytoplasmic dynein 1 heavy chain 1 [OS=Mus musculus] | 161.009 | 14 | 55 | 258 | 55 | 4644 | 531.7 | cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes | cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 13424 | ENSMUSG00000018707 | Dync1h1 | E9QM71; mmu:13424; Q9JHU4 | MHC class II antigen presentation; Neutrophil degranulation; Separation of Sister Chromatids; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; COPI-mediated anterograde transport; Recruitment of NuMA to mitotic centrosomes; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-independent Golgi-to-ER retrograde traffic; Aggrephagy; Anchoring of the basal body to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; AURKA Activation by TPX2 | 0.591873375996003 | 0.826895204418257 | 0.758743075163871 | 0.936818656936794 | 0.771389136401717 | 0.987352798667733 | 0.695927216301667 | 0.953305976192702 | 224060.75101347 | 288932.991027563 | 370866.333925136 | 1035717.43113769 | 1898525.78207622 | 892363.147243056 | 298543.620628635 | 395801.785314415 | 659710.172961205 | 5741364.17159479 | 5412980.23144293 | 4332188.15134028 | 1541170.38578568 | 1219184.02821873 | 1626625.47525789 | |
| Q9DCX2 | ATP synthase subunit d, mitochondrial [OS=Mus musculus] | 5.761 | 14 | 2 | 2 | 2 | 161 | 18.7 | other metabolic processes;transport | other membranes;mitochondrion | transporter activity | 71679 | ENSMUSG00000034566 | Atp5pd | B1ASE1; mmu:71679; Q542H1; Q7M0I0; Q91YK9; Q9DCX2 | Oxidative phosphorylation; Electron transport chain | Mitochondrial protein degradation; Formation of ATP by chemiosmotic coupling; Cristae formation | 1.65082956259427E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.409840751945386 | 5.07936507936508E-17 | 5.0092807424594E-17 | 0.946345704797138 | 19192.2208760517 | 13108.8785793139 | 130081.940751203 | 100021.130773487 | 87903.3732459527 | 52632.9085654534 | 32307.792277534 | |||||||||
| Q9WV55 | Vesicle-associated membrane protein-associated protein A [OS=Mus musculus] | 5.885 | 14 | 3 | 3 | 2 | 249 | 27.8 | cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component | cytoskeletal activity;other molecular function | 30960 | ENSMUSG00000024091 | Vapa | mmu:30960; Q3TJM1; Q9QY77; Q9WV55 | Exercise-induced circadian regulation | Neutrophil degranulation; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 1.65082956259427E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.634569013340978 | 5.07936507936508E-17 | 5.0092807424594E-17 | 0.901489646134689 | 12200.466947703 | 11486.3752383246 | 56688.763191401 | 36501.3441685188 | 20157.5188423311 | 12325.3102881615 | 18418.0810246496 | |||||||||
| Q91YQ5 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 [OS=Mus musculus] | 20.859 | 14 | 7 | 18 | 7 | 608 | 68.5 | protein metabolism;other metabolic processes | other membranes;cytosol;ER/Golgi | 103963 | ENSMUSG00000030062 | Rpn1 | mmu:103963; Q3U985; Q91YQ5 | Proteasome degradation | Regulation of CDH1 posttranslational processing and trafficking to plasma membrane | 1.65082956259427E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.658079671956821 | 5.07936507936508E-17 | 5.0092807424594E-17 | 0.941622073331623 | 52967.3975336539 | 352532.827232894 | 421807.726945174 | 366669.377352316 | 102407.901526065 | 88750.7458999714 | 50588.3498323333 | ||||||||||
| Q91WK2 | Eukaryotic translation initiation factor 3 subunit H [OS=Mus musculus] | 11.494 | 14 | 4 | 16 | 4 | 352 | 39.8 | cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes | translational apparatus;other cell component | other molecular function | 68135 | ENSMUSG00000022312 | Eif3h | mmu:68135; Q91WK2 | Translation factors | L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.976873891151678 | 0.459512976435992 | 0.766097857354292 | 0.976852696203657 | 132495.548712193 | 86560.5040361529 | 41667.7794889329 | 41718.0402650077 | 54464.8411089554 | 93817.2683152144 | 245232.567745635 | 204464.876530038 | 197997.45877567 | 49438.8307105859 | 28913.5808165915 | ||||
| Q9WUM3 | Coronin-1B [OS=Mus musculus] | 20.376 | 14 | 6 | 35 | 6 | 484 | 53.9 | cell organization and biogenesis;stress response;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 23789 | ENSMUSG00000024835 | Coro1b | mmu:23789; Q3UEB1; Q9CVA2; Q9WUM3 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.494998296622944 | 0.671487757610407 | 0.904360680536565 | 0.880760468933162 | 105532.365339245 | 124753.466752389 | 50334.0472385688 | 23571.1924966367 | 76675.250580423 | 97155.0774211608 | 677246.130593822 | 607327.685960935 | 477245.691921694 | 133797.820292752 | 52326.05588713 | 111202.070531327 | |||||
| P56135 | ATP synthase subunit f, mitochondrial [OS=Mus musculus] | 2.894 | 14 | 1 | 3 | 1 | 88 | 10.3 | other metabolic processes;transport | other membranes;nucleus | transporter activity | 57423 | ENSMUSG00000038690 | Atp5mf | mmu:57423; P56135; Q3THX9; Q9JMF4 | Oxidative phosphorylation; Electron transport chain | Formation of ATP by chemiosmotic coupling; Cristae formation | 1.50457038391225E-17 | 6.99442896935933E-17 | 5.71658986175115E-17 | 86989.8329532427 | 97472.388555257 | 80617.1722955862 | |||||||||||||||||
| Q8R016 | Bleomycin hydrolase [OS=Mus musculus] | 15.577 | 14 | 6 | 37 | 6 | 455 | 52.5 | protein metabolism;other biological processes | other cell component | other molecular function | 104184 | ENSMUSG00000020840 | Blmh | mmu:104184; Q3TJR8; Q8BLZ4; Q8BZH9; Q8C111; Q8CID9; Q8R016 | Comprehensive IL-17A signaling | Antigen processing: Ubiquitination & Proteasome degradation | 0.554010322700456 | 0.334437600560151 | 0.889322773294568 | 0.336509170512301 | 0.515661736608057 | 0.938673371173823 | 1926.26094563279 | 26085.2455293462 | 124155.814868436 | 153814.928487987 | 158548.738631719 | 18110.6055568754 | 13358.0055422317 | 25235.4049958981 | 427481.494772467 | 347315.357394715 | 380593.01466616 | 237957.699464002 | 121580.498536854 | 138649.943276401 | |||
| P62918 | Large ribosomal subunit protein uL2 [OS=Mus musculus] | 16.948 | 14 | 3 | 51 | 3 | 257 | 28 | protein metabolism;other metabolic processes | cytosol;translational apparatus;other cell component | nucleic acid binding activity;other molecular function | 26961 | ENSMUSG00000003970 | Rpl8 | mmu:26961; P25120; P62918; Q3V288 | Cytoplasmic ribosomal proteins; mRNA processing | L13a-mediated translational silencing of Ceruloplasmin expression; SRP-dependent cotranslational protein targeting to membrane; Major pathway of rRNA processing in the nucleolus and cytosol; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Protein hydroxylation | 0.996848625450089 | 0.843570014444047 | 0.850600578281519 | 0.819340754966959 | 0.849115330648105 | 0.541988404701918 | 0.902801979444386 | 0.686547064791248 | 222475.791110659 | 225424.366207059 | 190634.325954156 | 555460.522879262 | 522353.241418517 | 526058.49719638 | 565610.90608527 | 527899.52745823 | 709859.510946721 | 1165908.36565515 | 1087460.87143087 | 836239.339279191 | 623814.167786176 | 773624.465350564 | 903244.376801511 |
| Q08048 | Hepatocyte growth factor [OS=Mus musculus] | 40.527 | 14 | 9 | 60 | 9 | 728 | 82.9 | cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;developmental processes;signal transduction;other biological processes | non-structural extracellular | signal transduction activity or receptor binding;other molecular function | 15234 | ENSMUSG00000028864 | Hgf | mmu:15234; O55027; Q08048; Q53WS5; Q61662; Q64007; Q6LBE6 | Hepatocyte growth factor receptor signaling; Focal adhesion: PI3K-Akt-mTOR signaling pathway; Lung fibrosis; Hypoxia-dependent proliferation of myoblasts; Focal adhesion | MET activates PTK2 signaling; Platelet degranulation ; MET interacts with TNS proteins; RAF/MAP kinase cascade; PIP3 activates AKT signaling; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; MET Receptor Activation; Negative regulation of MET activity; MET activates RAS signaling; MET activates PI3K/AKT signaling; MET activates PTPN11; MET activates RAP1 and RAC1; MET receptor recycling; MET activates STAT3; Drug-mediated inhibition of MET activation | 0.188131780045305 | 0.0926108593473612 | 0.619345403494574 | 0.00687496077496375 | 0.853361143945713 | 0.165943167737706 | 0.809503222445875 | 18383.1610088344 | 1420312.36498057 | 1461913.27013873 | 917073.450255835 | 652642.719960309 | 544379.748589189 | 509528.867713055 | 143868.721326985 | 183449.27029887 | 106355.272863837 | 48742.5543928372 | |||||
| P29595 | Ubiquitin-like protein NEDD8 [OS=Mus musculus] | 3.892 | 14 | 1 | 11 | 1 | 81 | 9 | protein metabolism;other metabolic processes;other biological processes | cytosol;nucleus;other cell component | other molecular function | 18002 | ENSMUSG00000010376 | Nedd8 | mmu:18002; P29595 | Neddylation; TGF-beta receptor signaling activates SMADs; Cargo recognition for clathrin-mediated endocytosis; UCH proteinases; Iron uptake and transport | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 0.854305439376382 | 0.967845631875583 | 5.0092807424594E-17 | 5.71658986175115E-17 | 73472.2873436729 | 71192.5053661943 | 35942.5332302588 | 38046.269827602 | 23320.1734953622 | 54467.1237485558 | 170685.820829579 | 83445.9451298353 | 107867.894502892 | ||||||||
| P12850 | Growth-regulated alpha protein [OS=Mus musculus] | 5.105 | 14 | 1 | 9 | 1 | 96 | 10.2 | stress response;signal transduction;other biological processes | non-structural extracellular | signal transduction activity or receptor binding | 14825 | ENSMUSG00000029380 | Cxcl1 | mmu:14825; P12850 | Cytokines and inflammatory response; Chemokine signaling pathway; Spinal cord injury; Comprehensive IL-17A signaling | Neutrophil degranulation; G alpha (i) signalling events; Chemokine receptors bind chemokines | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 0.0516806986933162 | 0.372702055561289 | 5.0092807424594E-17 | 5.71658986175115E-17 | 127081.056221219 | 136513.492982114 | 118690.960959823 | 144580.847969804 | 168083.644138118 | 139508.218796195 | 27962.1809362785 | 72264.8711191931 | ||||||||
| Q3V1G4 | Olfactomedin-like protein 2B [OS=Mus musculus] | 44.355 | 14 | 8 | 65 | 8 | 746 | 83.5 | cell organization and biogenesis | non-structural extracellular;extracellular matrix | other molecular function | 320078 | ENSMUSG00000038463 | Olfml2b | mmu:320078; Q3T9I5; Q3V1G4; Q8C106; Q8R3B2 | 0.853466990454233 | 0.989158026391143 | 0.844378354675745 | 0.40936264125167 | 0.634569013340978 | 0.98558531112136 | 0.207131833826965 | 0.547723108056311 | 46832.664740596 | 2035117.32202037 | 2256456.54206124 | 1742901.95140084 | 1027602.68458177 | 897439.613943353 | 803120.762622037 | 1643471.30487656 | 1534411.79497865 | 933923.834704359 | 313527.641048155 | 228627.821226896 | 343695.614914493 | ||||
| P97464 | Exostosin-1 [OS=Mus musculus] | 25.656 | 14 | 9 | 28 | 9 | 746 | 86.3 | cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | other membranes;ER/Golgi;other cell component | other molecular function | 14042 | ENSMUSG00000061731 | Ext1 | mmu:14042; P97464; Q61546 | HS-GAG biosynthesis | 0.838937790409872 | 0.994542145304377 | 0.806371819826054 | 0.735120891924514 | 0.340399512012736 | 0.813710680257875 | 0.946018783860301 | 0.0962679688119245 | 24223.9556696224 | 262796.003641544 | 438917.018912159 | 627326.948618858 | 526422.395545923 | 82726.5979761042 | 93440.3373325565 | 306508.042873471 | 327386.321507147 | 486287.961222562 | 201615.000521216 | 87957.1825781445 | 368287.940629703 | 375213.472386912 | ||
| Q9WVB4 | Slit homolog 3 protein [OS=Mus musculus] | 68.959 | 14 | 16 | 95 | 16 | 1523 | 167.6 | cell organization and biogenesis;developmental processes;signal transduction;other biological processes | non-structural extracellular;plasma membrane;other membranes | signal transduction activity or receptor binding;other molecular function | 20564 | ENSMUSG00000056427 | Slit3 | B1ATW4; mmu:20564; Q9WVB4 | Spinal cord injury | Signaling by ROBO receptors | 0.20690035320339 | 0.178134691404138 | 0.758743075163871 | 0.887279041944908 | 0.403894201414054 | 0.941920360687835 | 0.968364585136618 | 0.445941831782188 | 35283.6162564558 | 985059.711989168 | 1275115.97108979 | 602345.407249721 | 527884.018150792 | 348587.621586001 | 533135.308907982 | 811881.558397095 | 704604.206827331 | 524636.419989735 | 287196.943634538 | 184834.23722991 | 444613.378122903 | ||
| Q9CQE8 | RNA transcription, translation and transport factor protein [OS=Mus musculus] | 6.873 | 14 | 3 | 10 | 3 | 244 | 28.1 | RNA metabolism OR transcription;other metabolic processes;other biological processes | cytosol;cytoskeleton;nucleus;other cell component | nucleic acid binding activity;other molecular function | 68045 | ENSMUSG00000021807 | RTRAF | mmu:68045; Q9CQE8 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.946568086066385 | 0.59453654985585 | 0.782411808078787 | 36239.0375525447 | 54015.7312332242 | 34833.7238906687 | 8748.2775033044 | 162148.813938426 | 149124.216335788 | 140692.582343043 | 33593.2396720867 | 13476.6645929751 | 19353.5236413161 | ||||||||
| Q9EP95 | Resistin-like alpha [OS=Mus musculus] | 3.774 | 14 | 1 | 2 | 1 | 111 | 11.9 | signal transduction;other biological processes | non-structural extracellular | signal transduction activity or receptor binding | 57262 | ENSMUSG00000061100 | Retnla | mmu:57262; Q9D8Y4; Q9EP95 | 1.50457038391225E-17 | 1.70336894001643E-17 | 6.99442896935933E-17 | 5.0092807424594E-17 | 0.508811363076011 | 45019.3416592044 | 53632.3127093339 | 40964.700911817 | 40478.2627306796 | 44956.6943760296 | |||||||||||||||
| O35841 | Apoptosis inhibitor 5 [OS=Mus musculus] | 17.293 | 13 | 6 | 25 | 6 | 504 | 56.8 | other biological processes | nucleus;other cell component | other molecular function | 11800 | ENSMUSG00000027193 | Api5 | mmu:11800; O35841; Q3U517; Q922L2 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.96340270250964 | 0.97527107273228 | 0.638748509735888 | 0.48844218741759 | 393196.220799642 | 675263.642796611 | 399633.166690916 | 334633.929995814 | 239676.372426044 | 319650.91387755 | 1044793.60028204 | 784768.684150858 | 882202.020594905 | 175460.068123473 | 112740.975677548 | 218518.535434525 | |||||
| O08859 | Tumor necrosis factor-inducible gene 6 protein [OS=Mus musculus] | 5.071 | 13 | 4 | 13 | 4 | 275 | 30.9 | cell adhesion;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes | non-structural extracellular | other molecular function | 21930 | ENSMUSG00000053475 | Tnfaip6 | mmu:21930; O08859 | Neutrophil degranulation | 0.768884976331745 | 0.604896117649746 | 0.702494768959932 | 0.783385905917872 | 0.838771684564386 | 0.247752364325082 | 0.959009572701759 | 0.00891632272606812 | 549913.330153393 | 664921.685965724 | 349816.173124402 | 940474.408408866 | 906009.424229515 | 706246.127245491 | 482661.159177842 | 492046.058953194 | 1157191.63593248 | 918971.177485964 | 989600.931130411 | 563640.56326903 | 673169.515461073 | 688909.696103786 | 1117881.25746275 | |
| Cont_G5E513 | Uncharacterized protein OS=Bos taurus OX=9913 PE=1 SV=2 | 14.523 | 13 | 4 | 24 | 4 | 439 | 48.1 | 0.988152251779719 | 0.907491776997927 | 0.781153691772611 | 0.839216523231753 | 0.946568086066385 | 0.14312565543746 | 0.335956814949331 | 0.989544231571828 | 17563.19498085 | 3757.06141750122 | 22129.9133678475 | 136920.579754173 | 184453.709402844 | 119218.256299661 | 235822.744756768 | 239899.966167781 | 190527.570421646 | 292912.909537899 | 243182.437616418 | 218230.987412637 | 80671.294499933 | 45201.8711958389 | 90466.2089034346 | |||||||||
| Q3THS6 | S-adenosylmethionine synthase isoform type-2 [OS=Mus musculus] | 11.873 | 13 | 3 | 20 | 3 | 395 | 43.7 | cell organization and biogenesis;other metabolic processes;other biological processes | other cell component | other molecular function | 232087 | ENSMUSG00000053907 | Mat2a | mmu:232087; Q3THS6; Q3TL60; Q76LX3 | Methylation; One-carbon metabolism and related pathways | Methylation | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.990459928977729 | 0.994834213681465 | 0.883874206034266 | 0.862285136793786 | 72905.391336543 | 101232.77113725 | 30493.2904491875 | 64322.7061273834 | 179446.087925276 | 149987.578768739 | 129803.138530944 | 38056.3253212917 | |||||||
| Q8K4Z5 | Splicing factor 3A subunit 1 [OS=Mus musculus] | 23.02 | 13 | 9 | 30 | 9 | 791 | 88.5 | cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes | nucleus | nucleic acid binding activity | 67465 | ENSMUSG00000002129 | Sf3a1 | mmu:67465; Q8C0M7; Q8C128; Q8C175; Q8K4Z5; Q921T3 | mRNA processing | mRNA Splicing - Major Pathway | 0.469735153113543 | 0.637206331155226 | 0.916283277860523 | 0.819784904009125 | 0.947768687612402 | 0.574815364367783 | 34921.6641180446 | 237238.800012932 | 194518.74918863 | 96217.4796233405 | 18646.9221763795 | 43438.2811375051 | 60619.7938012811 | 782324.58176055 | 421633.488113009 | 398132.278571425 | 25854.5238345436 | 11939.4398140554 | |||||
| Q9JMA1 | Ubiquitin carboxyl-terminal hydrolase 14 [OS=Mus musculus] | 19.986 | 13 | 6 | 38 | 6 | 493 | 56 | cell-cell signaling;protein metabolism;other metabolic processes;stress response;other biological processes | plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component | enzyme regulator activity;other molecular function | 59025 | ENSMUSG00000047879 | Usp14 | mmu:59025; Q543U5; Q923F2; Q9D0L0; Q9JMA1 | Ub-specific processing proteases; Regulation of NF-kappa B signaling | 0.108691078158962 | 0.108263998771695 | 0.152226763216414 | 0.250942353982195 | 0.938859506774495 | 0.900334730044572 | 0.985707795620743 | 0.915193515309545 | 5277.53004802672 | 330156.999889693 | 358004.806432472 | 183352.263547602 | 77252.8766016428 | 82077.0445999779 | 206074.390687363 | 434284.773876331 | 409240.75922847 | 273653.01408736 | 108799.129230956 | 22422.4914767181 | 145571.149670246 | |||
| Q9CQ48 | NudC domain-containing protein 2 [OS=Mus musculus] | 5.757 | 13 | 2 | 11 | 2 | 157 | 17.6 | cytosol;cytoskeleton;other cell component | 52653 | ENSMUSG00000020328 | Nudcd2 | mmu:52653; Q8CD03; Q9CQ48; Q9CY63; Q9D0V4 | 0.422266829533603 | 0.862605597436246 | 0.946568086066385 | 0.904392641853656 | 0.627633074049438 | 0.780745198104368 | 26948.8611140738 | 18649.9203175298 | 61987.9191063489 | 49851.7834442891 | 51558.650717381 | 36599.3616920877 | 307929.57510277 | 272916.52565326 | 245301.950056024 | 132083.845824952 | 61248.1560765265 | 56898.627830368 | |||||||||
| Q6NSR8 | Probable aminopeptidase NPEPL1 [OS=Mus musculus] | 18.405 | 13 | 5 | 32 | 5 | 524 | 55.9 | protein metabolism | other cell component | other molecular function | 228961 | ENSMUSG00000039263 | Npepl1 | A2ACM6; mmu:228961; Q66JY0; Q6NSR8 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.916864373365557 | 0.862995340297496 | 0.937453377971347 | 0.915193515309545 | 103512.281066319 | 146550.877912848 | 114539.334706296 | 25861.2213528749 | 322207.31739392 | 292398.333279516 | 317824.843067081 | 96045.2371067411 | 93318.839319396 | 124822.917264956 | |||||||
| Cont_Q2HJF0 | Serotransferrin-like OS=Bos taurus OX=9913 GN=LOC525947 PE=2 SV=1 | 16.9 | 13 | 8 | 51 | 5 | 622 | 69.1 | non-structural extracellular | other molecular function | LOC525947 | bta:525947; Q2HJF0 | 0.714071857030863 | 0.891570855936178 | 0.612685183226485 | 0.760498481134506 | 0.816275429153737 | 0.270575509370853 | 0.901149690306505 | 0.0442327547235724 | 269891.614782118 | 323194.655403009 | 160674.80491318 | 331095.590878816 | 340012.729187756 | 346747.431012538 | 478280.18859645 | 433985.324398465 | 495046.696532048 | 349322.63352409 | 354519.280674508 | 271395.909835392 | 227016.282690147 | 71573.943473779 | 565865.882367658 | |||||
| P09602 | Non-histone chromosomal protein HMG-17 [OS=Mus musculus] | 3.173 | 13 | 1 | 6 | 1 | 90 | 9.4 | other biological processes | nucleus;other cell component | nucleic acid binding activity | 15331 | ENSMUSG00000003038; ENSMUSG00000070713 | Hmgn2 | mmu:15331; P09602 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.946568086066385 | 0.869908412860824 | 0.201453900348569 | 0.510179677840388 | 9289.49729768589 | 19968.9411502603 | 11643.9356328852 | 3748.37662935584 | 40604.6739025885 | 21444.5070835828 | 14654.6123132029 | 20605.6295540082 | |||||||||
| P45377 | Aldose reductase-related protein 2 [OS=Mus musculus] | 10.179 | 13 | 6 | 29 | 5 | 316 | 36.1 | other metabolic processes | other cell component | other molecular function | 14187 | ENSMUSG00000029762 | Akr1b8 | mmu:14187; P45377; Q99JN4 | Estrogen biosynthesis | 1.65082956259427E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.614867638984303 | 5.07936507936508E-17 | 5.0092807424594E-17 | 0.953305976192702 | 33472.1000324933 | 27975.8518741154 | 21690.2526073915 | 228526.000343216 | 87823.0636125152 | 66785.455377344 | 49713.0425510229 | 39487.6292410233 | |||||||||
| P62267 | Small ribosomal subunit protein uS12 [OS=Mus musculus] | 5.964 | 13 | 2 | 14 | 2 | 143 | 15.8 | cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes | cytosol;ER/Golgi;translational apparatus;nucleus;other cell component | other molecular function | 66475 | ENSMUSG00000049517 | Rps23 | mmu:66475; P39028; P62267; Q542K7 | Cytoplasmic ribosomal proteins; mRNA processing | L13a-mediated translational silencing of Ceruloplasmin expression; SRP-dependent cotranslational protein targeting to membrane; Major pathway of rRNA processing in the nucleolus and cytosol; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; Protein hydroxylation | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.678323397545056 | 0.604710860103885 | 0.975029032316037 | 63296.3168964688 | 121288.407536748 | 84344.8564281305 | 94720.8393888893 | 70723.3958690644 | 81916.4343942219 | 379007.478679618 | 291267.298896875 | 321599.276899445 | 24266.0533554044 | 19089.0381617533 | |||||
| Q8BKG3 | Inactive tyrosine-protein kinase 7 [OS=Mus musculus] | 36.864 | 13 | 11 | 59 | 11 | 1062 | 117.5 | cell adhesion;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes | plasma membrane;other membranes;cytosol;other cell component | 71461 | ENSMUSG00000023972 | Ptk7 | mmu:71461; Q3V422; Q6W8S9; Q8BKG3; Q8CHK5; Q8K178 | 0.968226484606999 | 0.826769890733016 | 0.929027730652974 | 0.626523115896859 | 0.976873891151678 | 0.897374575947205 | 0.715124368113521 | 0.971151633247904 | 132609.190003098 | 213306.543118289 | 101392.222061 | 451855.978202703 | 605033.253003081 | 624909.633793356 | 452184.651254255 | 405552.144634704 | 507926.274932897 | 1311357.23833895 | 1074253.8441772 | 779256.779434463 | 348285.208082859 | 138581.66690071 | 377898.814116878 | |||
| Q921M7 | CYFIP-related Rac1 interactor B [OS=Mus musculus] | 11.132 | 13 | 3 | 10 | 3 | 324 | 36.8 | cell organization and biogenesis;other biological processes | other membranes;mitochondrion;other cell component | signal transduction activity or receptor binding;other molecular function | 223601 | ENSMUSG00000022378 | Cyrib | mmu:223601; Q921M7 | Platelet degranulation | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.974036928885484 | 0.341480991208153 | 0.883039867519245 | 0.622880861621114 | 37345.994583155 | 27993.7930631354 | 25894.4722931883 | 8435.5375668447 | 49285.1188325947 | 75170.3012295857 | 41326.2950817217 | 4893.14687678703 | 12109.273081587 | 18476.429719851 | ||||||
| P84099 | Large ribosomal subunit protein eL19 [OS=Mus musculus] | 3.775 | 13 | 2 | 21 | 2 | 196 | 23.5 | protein metabolism;other metabolic processes | cytosol;translational apparatus;nucleus;other cell component | nucleic acid binding activity;other molecular function | 19921 | ENSMUSG00000017404 | Rpl19 | mmu:19921; P14118; P22908; P84099 | Cytoplasmic ribosomal proteins; mRNA processing | Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; SRP-dependent cotranslational protein targeting to membrane; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 1.65082956259427E-17 | 0.0422566528998357 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.968175059132934 | 0.770634810212039 | 0.661765596176351 | 0.711902858921665 | 14838.5198375531 | 11272.7581684983 | 13733.0973273265 | 335413.676368476 | 347962.586918886 | 281488.060193708 | 138685.087507924 | 118529.34380185 | 185072.428619123 | 631413.073428127 | 517606.896032981 | 431105.572334904 | 303802.386853128 | 265309.005373969 | 266852.112092429 |
| Q62189 | U1 small nuclear ribonucleoprotein A [OS=Mus musculus] | 8.62 | 13 | 5 | 10 | 5 | 287 | 31.8 | RNA metabolism OR transcription;other metabolic processes | nucleus | nucleic acid binding activity;other molecular function | 53607 | ENSMUSG00000061479 | Snrpa | mmu:53607; Q52LA2; Q62189 | miRNAs and TFs in iPS Cell Generation; mRNA processing | mRNA Splicing - Major Pathway | 0.859641662417994 | 0.56631889132907 | 0.358707752055338 | 0.540124873725708 | 0.988377544628277 | 0.868312654196633 | 45509.4973523362 | 33879.3136279062 | 65108.0842635308 | 69581.5277933384 | 108703.922882423 | 39971.4392548994 | 72050.0768378988 | 544877.250815311 | 460584.592733898 | 325994.192658696 | 161551.034170843 | 110410.902520629 | |||||
| Q80SZ7 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [OS=Mus musculus] | 2.458 | 13 | 1 | 3 | 1 | 68 | 7.3 | signal transduction;other biological processes | plasma membrane;other membranes;other cell component | other molecular function | 14707 | ENSMUSG00000068523 | Gng5 | mmu:14707; P30670; Q5I0W4; Q61015; Q80SZ7 | Chemokine signaling pathway; G protein signaling pathways; Focal adhesion: PI3K-Akt-mTOR signaling pathway; Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells | G alpha (q) signalling events; G alpha (12/13) signalling events; Ca2+ pathway; G beta:gamma signalling through PLC beta; Presynaptic function of Kainate receptors; G alpha (i) signalling events; ADP signalling through P2Y purinoceptor 12; Adrenaline,noradrenaline inhibits insulin secretion; Extra-nuclear estrogen signaling; G alpha (s) signalling events; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Vasopressin regulates renal water homeostasis via Aquaporins; Thromboxane signalling through TP receptor; High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells; Thrombin signalling through proteinase activated receptors (PARs); G-protein activation; Glucagon-type ligand receptors; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; G alpha (z) signalling events; G beta:gamma signalling through CDC42; Activation of G protein gated Potassium channels; Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits; GPER1 signaling; ADP signalling through P2Y purinoceptor 1; G beta:gamma signalling through PI3Kgamma; Prostacyclin signalling through prostacyclin receptor; G beta:gamma signalling through BTK | 1.50457038391225E-17 | 1.70336894001643E-17 | 6.99442896935933E-17 | 5.0092807424594E-17 | 0.835383236382767 | 93492.8294877387 | 185177.642042253 | 66113.6459194315 | 50129.9740917465 | 27565.622350751 | |||||||||||||
| P24547 | Inosine-5'-monophosphate dehydrogenase 2 [OS=Mus musculus] | 25.617 | 13 | 6 | 58 | 6 | 514 | 55.8 | cell cycle OR cell proliferation;other metabolic processes;other biological processes | cytosol;nucleus;other cell component | nucleic acid binding activity;other molecular function | 23918 | ENSMUSG00000062867 | Impdh2 | mmu:23918; P24547; Q61734; Q91Z11 | Purine metabolism | Neutrophil degranulation; Azathioprine ADME; Purine ribonucleoside monophosphate biosynthesis | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.873755746039336 | 0.862995340297496 | 0.627557777049862 | 0.809503222445875 | 545033.994696958 | 582799.967002973 | 141539.876542747 | 296304.483702097 | 178089.551804616 | 437752.720263561 | 569402.686894333 | 597402.163759587 | 434583.758316533 | 77751.222939471 | 51407.8305729009 | 215024.491443524 | |||
| Q9D7I0 | Protein shisa-5 [OS=Mus musculus] | 10.119 | 13 | 2 | 13 | 2 | 235 | 25.5 | stress response;signal transduction | other membranes;ER/Golgi;nucleus | 66940 | ENSMUSG00000025647 | Shisa5 | mmu:66940; Q8BJ86; Q8BJ87; Q8BLE9; Q8K4W3; Q91Z37; Q9CQP5; Q9D7I0 | p53 signaling | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 1.65082956259427E-17 | 1.70336894001643E-17 | 6.99442896935933E-17 | 5.07936507936508E-17 | 5.0092807424594E-17 | 5.71658986175115E-17 | 73217.0965269246 | 73638.606136807 | 50342.6958740552 | 39796.1900262267 | 87266.2911311718 | |||||||||||||
| Q99KF1 | Transmembrane emp24 domain-containing protein 9 [OS=Mus musculus] | 5.144 | 13 | 2 | 13 | 2 | 235 | 27.1 | cell organization and biogenesis;transport;other biological processes | other membranes;ER/Golgi | other molecular function | 67511 | ENSMUSG00000058569 | Tmed9 | mmu:67511; Q99KF1; Q9CX02 | COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport | 0.133091263495378 | 0.156805181550149 | 0.223749122767877 | 0.170133062503756 | 0.713728875550882 | 0.29502780069942 | 0.777395712279767 | 0.186337420169505 | 2493442.6083058 | 2706089.5438242 | 1.40040153991257E7 | 778672.023841508 | 3631009.1603526 | 4872698.46222444 | 3889244.22974851 | 7921018.05022019 | 793301.062701119 | 2436436.23500687 | 3156729.38802362 | 1.06482460991872E7 | 2256588.36277689 | 3021166.5293649 | 3686427.7542927 | |
| P40336 | Vacuolar protein sorting-associated protein 26A [OS=Mus musculus] | 15.156 | 13 | 3 | 17 | 3 | 327 | 38.1 | transport | other membranes;cytosol;other cytoplasmic organelle;other cell component | 30930 | ENSMUSG00000020078 | Vps26a | mmu:30930; P40336; Q3TGY3; Q3THM5; Q3TW99; Q3UD54; Q8C1E9 | WNT ligand biogenesis and trafficking | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.968175059132934 | 0.97527107273228 | 0.903936753250945 | 0.846709543118794 | 161363.069406795 | 145856.970017824 | 141756.284928569 | 42838.526944965 | 330110.851135014 | 271346.85411075 | 205523.860433752 | 100782.513367538 | 59797.8671004894 | ||||||||
| Q8CI59 | Metalloreductase STEAP3 [OS=Mus musculus] | 19.556 | 13 | 6 | 48 | 6 | 488 | 54.7 | transport;other biological processes | plasma membrane;other membranes;other cytoplasmic organelle | other molecular function | 68428 | Steap3 | mmu:68428; Q3TKE4; Q80ZF3; Q8C5F0; Q8CI59; Q924Z1 | p53 signaling | RHOQ GTPase cycle; RHOF GTPase cycle; RHOD GTPase cycle; Transferrin endocytosis and recycling; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.653431363974602 | 0.824015152205967 | 0.654871320915497 | 0.915790191796374 | 0.964629994744883 | 0.56053198781818 | 0.535805337969424 | 0.870189287384328 | 378348.400918866 | 191352.049366962 | 264896.669326824 | 695452.087046779 | 908269.389362189 | 872428.997509702 | 177800.30025997 | 130968.001259329 | 334367.726809593 | 1062153.61065335 | 1275268.7419006 | 1172284.57355865 | 490006.230508796 | 276281.890470985 | 828799.372454213 | |
| Q8BL97 | Serine/arginine-rich splicing factor 7 [OS=Mus musculus] | 7.892 | 13 | 3 | 22 | 2 | 267 | 30.8 | RNA metabolism OR transcription;other metabolic processes;transport;other biological processes | nucleus;other cell component | nucleic acid binding activity;other molecular function | 225027 | ENSMUSG00000024097 | Srsf7 | mmu:225027; Q8BL97; Q8BMC6; Q8BUR2; Q8R2N4; Q8R3E9; Q91YS1 | mRNA processing | mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.957324015670425 | 0.482709527922337 | 0.937453377971347 | 0.528663280321161 | 327538.000622635 | 368610.675502343 | 110757.092500674 | 131072.436079812 | 123820.919298141 | 366363.236100956 | 243670.721461193 | 239371.990951263 | 304065.460854908 | 160858.633331608 | 126641.949289884 | 175742.439316973 | |||
| Q6ZWY3 | Small ribosomal subunit protein eS27-like [OS=Mus musculus] | 2.422 | 13 | 1 | 4 | 1 | 84 | 9.5 | cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes | cytosol;translational apparatus;nucleus;other cell component | other molecular function | 67941 | ENSMUSG00000036781 | Rps27l | mmu:67941; Q3UB68; Q6ZWY3 | L13a-mediated translational silencing of Ceruloplasmin expression; SRP-dependent cotranslational protein targeting to membrane; Major pathway of rRNA processing in the nucleolus and cytosol; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.728197413962845 | 0.666468303662031 | 0.985707795620743 | 0.983766680568824 | 42451.3617505843 | 64676.3877640619 | 45981.5444024723 | 41198.3585393566 | 58639.9338443988 | 135715.72832682 | 143386.575724083 | 119775.508239705 | 66073.4749000341 | 39930.5201709628 | 67033.507438635 | |||||
| P62245 | Small ribosomal subunit protein uS8 [OS=Mus musculus] | 6.842 | 13 | 2 | 27 | 2 | 130 | 14.8 | protein metabolism;other metabolic processes;other biological processes | cytosol;translational apparatus;nucleus;other cell component | other molecular function | 267019 | ENSMUSG00000008683 | Rps15a | mmu:267019; P39027; P39031; P62245; Q8C023; Q9BV24 | Cytoplasmic ribosomal proteins | L13a-mediated translational silencing of Ceruloplasmin expression; SRP-dependent cotranslational protein targeting to membrane; Major pathway of rRNA processing in the nucleolus and cytosol; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.912218866069753 | 0.775427927270918 | 0.985707795620743 | 0.904618748989697 | 188368.571818352 | 224681.459712455 | 133235.846945973 | 128832.047294153 | 110353.942254882 | 167156.799815399 | 371070.261663626 | 443371.191733939 | 195140.111842904 | 150773.342200008 | 137987.262290717 | 412781.110543974 | |||
| Q8BH64 | EH domain-containing protein 2 [OS=Mus musculus] | 21.634 | 13 | 6 | 37 | 5 | 543 | 61.1 | cell organization and biogenesis;transport;other biological processes | plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component | other molecular function | 259300 | ENSMUSG00000074364 | Ehd2 | mmu:259300; Q8BH64; Q8BL28 | Insulin signaling | Factors involved in megakaryocyte development and platelet production | 1.65082956259427E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.380685529533638 | 5.07936507936508E-17 | 5.0092807424594E-17 | 0.814792658152594 | 53545.5845894864 | 117591.751819339 | 117405.291550533 | 500044.830486766 | 399141.30522285 | 491994.724484328 | 95786.4658483673 | 83462.7166553484 | 155946.366038793 | |||||||
| P17427 | AP-2 complex subunit alpha-2 [OS=Mus musculus] | 27.21 | 13 | 10 | 32 | 8 | 938 | 104 | transport;other biological processes | plasma membrane;other membranes;other cell component | other molecular function | 11772 | ENSMUSG00000002957 | Ap2a2 | mmu:11772; P17427; Q8C2J5; Q921V0 | Neutrophil degranulation; MHC class II antigen presentation; Recycling pathway of L1; Cargo recognition for clathrin-mediated endocytosis; LDL clearance; Trafficking of GluR2-containing AMPA receptors; Retrograde neurotrophin signalling; WNT5A-dependent internalization of FZD4; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation | 0.589939109659553 | 1.8644578313253E-17 | 0.158016228104371 | 0.472627209918188 | 0.732185883724745 | 5.07936507936508E-17 | 5.0092807424594E-17 | 0.76895109357435 | 87467.0864556009 | 208896.836362556 | 104616.726185192 | 108853.836932272 | 359928.415746998 | 882784.118198223 | 629974.582722611 | 578098.742156656 | 91989.8506253716 | 144814.388230465 | 139277.214032969 | |||||
| P70677 | Caspase-3 [OS=Mus musculus] | 13.162 | 13 | 3 | 28 | 3 | 277 | 31.5 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | plasma membrane;other membranes;cytosol;nucleus;other cell component | signal transduction activity or receptor binding;enzyme regulator activity;other molecular function | 12367 | ENSMUSG00000031628 | Casp3 | mmu:12367; O08668; P70677; Q8CHV5; Q9QWI4 | Apoptosis; Oxidative damage response; Apoptosis modulation by HSP70; Mechanisms associated with pluripotency; Alzheimer's disease; Spinal cord injury; p53 signaling; Parkinson's disease; IL-6 signaling pathway; Alpha 6 beta 4 integrin signaling pathway; Mapk signaling pathway; Na/K-ATPase/Src signaling; Comprehensive IL-17A signaling; IL19 signaling; FAS pathway and stress induction of HSP regulation; Toll-like receptor signaling | Apoptosis induced DNA fragmentation; Other interleukin signaling; Apoptotic cleavage of cell adhesion proteins; Pyroptosis; Caspase-mediated cleavage of cytoskeletal proteins; Activation of caspases through apoptosome-mediated cleavage; NADE modulates death signalling; SMAC, XIAP-regulated apoptotic response; Signaling by Hippo; Caspase activation via Dependence Receptors in the absence of ligand | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.971110042775673 | 0.947247164456515 | 0.725276065733107 | 0.943678408143527 | 171086.216190317 | 167178.504741513 | 185823.532082386 | 91952.187412971 | 98247.4583036501 | 161196.08294577 | 348027.012465873 | 303271.842854103 | 220731.120171495 | 105807.860376362 | 54111.9900550671 | 90613.125358564 | |||
| Q8CG19 | Latent-transforming growth factor beta-binding protein 1 [OS=Mus musculus] | 88.83 | 13 | 17 | 146 | 17 | 1712 | 186.6 | developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix | other molecular function | 268977 | ENSMUSG00000001870 | Ltbp1 | B1B1D9; B1B1E1; mmu:268977; O88349; Q505C9; Q8BNW7; Q8C7F5; Q8CG18; Q8CG19; Q8CIR0 | TGF-beta signaling pathway | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; TGF-beta receptor signaling activates SMADs; Molecules associated with elastic fibres | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.355502928358106 | 0.735421139117684 | 0.103207467912172 | 0.873178270224715 | 1953651.10977572 | 1994348.44215637 | 1232369.49034108 | 1112610.69435161 | 1183577.36116434 | 1485560.90907884 | 928603.123533148 | 852776.10116003 | 605149.21930318 | 241140.780830089 | 212043.542860448 | 276189.499420253 | |||
| Q06890 | Clusterin [OS=Mus musculus] | 16.496 | 13 | 5 | 21 | 5 | 448 | 51.6 | cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | non-structural extracellular;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;other molecular function | 12759 | ENSMUSG00000022037 | Clu | mmu:12759; Q06890 | Platelet degranulation ; Regulation of Complement cascade; Antimicrobial peptides; Terminal pathway of complement | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.0814045088916398 | 0.224559801557977 | 0.397987186613988 | 0.298649740469155 | 356742.964501795 | 392567.968037933 | 235333.093788484 | 50462.7401832172 | 53627.422793571 | 43226.8491187449 | 73388.2518520033 | 46868.5154230266 | 35042.5051735906 | 3670.14597404914 | ||||||
| P56959 | RNA-binding protein FUS [OS=Mus musculus] | 21.471 | 13 | 5 | 50 | 5 | 518 | 52.6 | cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes | cytosol;nucleus;other cell component | nucleic acid binding activity;other molecular function | 233908 | ENSMUSG00000030795 | Fus | mmu:233908; P56959 | mRNA processing | mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA | 0.280809834933866 | 0.224351337002317 | 0.153733903739226 | 0.879626257803594 | 0.964629994744883 | 0.922309781929271 | 0.814901278373128 | 0.400695172511484 | 12965.8719567476 | 34799.4208444307 | 704779.424495631 | 777571.273187695 | 705079.160511234 | 254985.495780537 | 161483.484892472 | 539860.103738302 | 1712115.18636347 | 1264115.62856777 | 906096.510474104 | 285086.911071813 | 146043.270397183 | 343757.276026296 | |
| Q9QZE5 | Coatomer subunit gamma-1 [OS=Mus musculus] | 29.788 | 13 | 9 | 56 | 9 | 874 | 97.5 | transport;other biological processes | other membranes;cytosol;ER/Golgi | other molecular function | 54161 | ENSMUSG00000030058 | Copg1 | mmu:54161; Q3U9F4; Q8BP96; Q8R1A7; Q922C6; Q9QZE5 | COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.890934699236284 | 0.975639188476386 | 0.97925982662951 | 0.573628445705172 | 210808.086107991 | 187476.602439949 | 71759.2334322375 | 41629.6578244802 | 61151.4505795776 | 89776.4747811416 | 680566.337487774 | 393457.580722317 | 315175.385472683 | 97497.3441391264 | 58997.8300731979 | 110953.255808655 | ||||
| Q9CXW4 | Large ribosomal subunit protein uL5 [OS=Mus musculus] | 7.216 | 13 | 2 | 25 | 2 | 178 | 20.2 | cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes | cytosol;translational apparatus;nucleus;other cell component | enzyme regulator activity;nucleic acid binding activity;other molecular function | 67025 | ENSMUSG00000059291 | Rpl11 | mmu:67025; Q3TPE3; Q6ZWY0; Q9CXW4 | Cytoplasmic ribosomal proteins; mRNA processing | L13a-mediated translational silencing of Ceruloplasmin expression; SRP-dependent cotranslational protein targeting to membrane; Major pathway of rRNA processing in the nucleolus and cytosol; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.709229396391097 | 0.687337054688946 | 0.388111386240804 | 0.882883691988085 | 144649.937248069 | 235434.257112025 | 155859.304378217 | 46467.933136012 | 45001.6290793477 | 78029.3935139715 | 477015.423241799 | 458411.044639866 | 431550.658354956 | 159471.975917287 | 111457.47142152 | 242431.650277028 | |||
| Q99LS3 | Phosphoserine phosphatase [OS=Mus musculus] | 4.154 | 13 | 3 | 9 | 3 | 225 | 25.1 | other metabolic processes;developmental processes;other biological processes | cytosol | other molecular function | 100678 | ENSMUSG00000029446 | Psph | mmu:100678; Q3TI16; Q5XHW3; Q99LS3 | Serine metabolism | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.53512553175426 | 0.696358249006924 | 0.336702291109547 | 0.668956177622973 | 77990.8355247935 | 122435.573946893 | 112361.201065933 | 24980.6173700214 | 20216.9559364532 | 36653.7498739433 | 32763.863696287 | 100562.091773322 | 35728.4991429191 | 10434.8232777412 | 14233.4936558942 |
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| Accession | Description | Sum PEP Score | Coverage [%] | # Peptides | # PSMs | # Unique Peptides | # AAs | MW [kDa] | Biological Process | Cellular Component | Molecular Function | Entrez Gene ID | Ensembl Gene ID | Gene Symbol | Gene ID | WikiPathways | Reactome Pathways | Abundance Ratio: (LQ_16h) / FM | Abundance Ratio: (LQ_6h) / FM | Abundance Ratio: (SQ_16h) / FM | Abundance Ratio: (SQ_6h) / FM | Abundance Ratio: (SQ_16h) / (LQ_16h) | Abundance Ratio: (LQ_16h) / (LQ_6h) | Abundance Ratio: (SQ_6h) / (LQ_6h) | Abundance Ratio: (SQ_16h) / (SQ_6h) | Abundance Ratio Adj. P-Value: (LQ_16h) / FM | Abundance Ratio Adj. P-Value: (LQ_6h) / FM | Abundance Ratio Adj. P-Value: (SQ_16h) / FM | Abundance Ratio Adj. P-Value: (SQ_6h) / FM | Abundance Ratio Adj. P-Value: (SQ_16h) / (LQ_16h) | Abundance Ratio Adj. P-Value: (LQ_16h) / (LQ_6h) | Abundance Ratio Adj. P-Value: (SQ_6h) / (LQ_6h) | Abundance Ratio Adj. P-Value: (SQ_16h) / (SQ_6h) | Abundances (Normalized): F1: Sample, FM | Abundances (Normalized): F2: Sample, FM | Abundances (Normalized): F3: Sample, FM | Abundances (Normalized): F8: Sample, LQ_16h | Abundances (Normalized): F9: Sample, LQ_16h | Abundances (Normalized): F10: Sample, LQ_16h | Abundances (Normalized): F4: Sample, LQ_6h | Abundances (Normalized): F5: Sample, LQ_6h | Abundances (Normalized): F6: Sample, LQ_6h | Abundances (Normalized): F17: Sample, SQ_16h | Abundances (Normalized): F18: Sample, SQ_16h | Abundances (Normalized): F20: Sample, SQ_16h | Abundances (Normalized): F14: Sample, SQ_6h | Abundances (Normalized): F15: Sample, SQ_6h | Abundances (Normalized): F16: Sample, SQ_6h |
| P11276 | Fibronectin [OS=Mus musculus] | 867.353 | 58 | 95 | 2246 | 59 | 2477 | 272.4 | cell adhesion;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi | signal transduction activity or receptor binding;enzyme regulator activity;other molecular function | 14268 | ENSMUSG00000026193 | Fn1 | G5E8B8; mmu:14268; P11276; Q61567; Q61568; Q61569; Q64233; Q80UI4 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Inflammatory response pathway; Regulation of actin cytoskeleton; Comprehensive IL-17A signaling; Focal adhesion | ECM proteoglycans; Platelet degranulation ; Cell surface interactions at the vascular wall; Syndecan interactions; MAP2K and MAPK activation; Integrin cell surface interactions; Molecules associated with elastic fibres; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Fibronectin matrix formation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; Degradation of the extracellular matrix; Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells; MET activates PTK2 signaling; GPER1 signaling | 16.191 | 18.678 | 20 | 12.982 | 1.439 | 0.984 | 0.516 | 2.74 | 0.0844744457809114 | 0.00584906503121538 | 1.50457038391225E-17 | 0.156115961659409 | 0.974036928885484 | 0.564710097967506 | 0.435823028559966 | 0.896613838854506 | 3.10111960161575E7 | 2.79853612635427E7 | 2.39278028537136E7 | 2.27076161669542E8 | 2.29530848002383E8 | 1.81481696567249E8 | 2.13523563015262E8 | 1.92386583493888E8 | 2.00792310651879E8 | 3.0604731494329E8 | 2.72875123758133E8 | 2.45952285820886E8 | 1.1928889459527E8 | 1.00071254189999E8 | 1.59531432686856E8 |
| P11087 | Collagen alpha-1(I) chain [OS=Mus musculus] | 797.017 | 79 | 75 | 1933 | 35 | 1453 | 137.9 | cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12842 | ENSMUSG00000001506 | Col1a1 | mmu:12842; P11087; Q53WT0; Q60635; Q61367; Q61427; Q63919; Q6PCL3; Q810J9 | Osteoblast signaling; Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Comprehensive IL-17A signaling; Focal adhesion | Cell surface interactions at the vascular wall; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ECM proteoglycans; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; GPVI-mediated activation cascade; GP1b-IX-V activation signalling; Platelet Adhesion to exposed collagen; Platelet Aggregation (Plug Formation); MET activates PTK2 signaling | 20 | 20 | 20 | 20 | 0.142 | 3.208 | 0.295 | 1.664 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 1.58880673198775E-4 | 0.381922652011049 | 0.0629214061377862 | 0.655833157547641 | 703080.609341466 | 1047026.5902454 | 567207.050774397 | 6.12803341835757E8 | 6.28616080368892E8 | 5.37143706349406E8 | 2.20652487774689E8 | 1.86114398805651E8 | 2.17194307013081E8 | 9.46570689754052E7 | 9.72166914362706E7 | 6.09758172025116E7 | 6.01286898886734E7 | 4.84358218594371E7 | 7.06441702532683E7 |
| Q01149 | Collagen alpha-2(I) chain [OS=Mus musculus] | 773.662 | 80 | 66 | 1731 | 51 | 1372 | 129.5 | cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12843 | ENSMUSG00000029661 | Col1a2 | mmu:12843; Q01149; Q8CGA5 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Focal adhesion | Crosslinking of collagen fibrils; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; ECM proteoglycans; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; GPVI-mediated activation cascade; GP1b-IX-V activation signalling; Platelet Adhesion to exposed collagen; Platelet Aggregation (Plug Formation); MET activates PTK2 signaling | 20 | 20 | 20 | 20 | 0.279 | 2.097 | 0.261 | 2.151 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.0150838661305169 | 0.862063111456553 | 0.0347692006632991 | 0.926292871155025 | 217896.573253055 | 102775.453905646 | 225868.955510701 | 3.82374533805921E8 | 3.80614155239716E8 | 2.79801552870279E8 | 1.73556920519588E8 | 1.55763113653521E8 | 1.89931753802048E8 | 1.03217412397752E8 | 1.04517075360638E8 | 6.33578194684048E7 | 4.96147162399626E7 | 2.65479311979207E7 | 5.19818116295111E7 |
| P08121 | Collagen alpha-1(III) chain [OS=Mus musculus] | 695.631 | 63 | 61 | 1789 | 51 | 1464 | 138.9 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | extracellular matrix;other cell component | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 12825 | ENSMUSG00000026043 | Col3a1 | mmu:12825; P08121; Q61429; Q9CRN7 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Focal adhesion | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ECM proteoglycans; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; MET activates PTK2 signaling | 20 | 20 | 20 | 20 | 0.247 | 5.055 | 0.497 | 2.464 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.00738207855214502 | 0.0413994480640273 | 0.394949139624895 | 0.976852696203657 | 619884.023482232 | 468692.52789102 | 275667.802679115 | 2.79020579584843E8 | 2.94236692581693E8 | 2.78582579285209E8 | 6.51340156000414E7 | 5.70632610319163E7 | 6.62894421161806E7 | 7.54516142044654E7 | 7.68700494785543E7 | 4.61499837269909E7 | 3.06665885804687E7 | 2.39448217703501E7 | 3.64849658219652E7 |
| Q9QXS1 | Plectin [OS=Mus musculus] | 659.702 | 46 | 182 | 1705 | 180 | 4691 | 533.9 | cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component | cytoskeletal activity;other molecular function | 18810 | ENSMUSG00000022565 | Plec | E9QN87; mmu:18810; Q6S384; Q6S389; Q6S394; Q9CS65; Q9QUT2; Q9QXQ8; Q9QXQ9; Q9QXR0; Q9QXR1; Q9QXR2; Q9QXR3; Q9QXR4; Q9QXR5; Q9QXR6; Q9QXR7; Q9QXR8; Q9QXR9; Q9QXS0; Q9QXS1; Q9QXS2; Q9QXS3 | Alpha 6 beta 4 integrin signaling pathway; EGFR1 signaling pathway | Type I hemidesmosome assembly; Caspase-mediated cleavage of cytoskeletal proteins | 5.459 | 2.593 | 9.846 | 4.989 | 2.383 | 2.864 | 1.839 | 3.715 | 0.481729871164266 | 0.714932595871944 | 0.336550483871782 | 0.572524806937582 | 0.850917681937748 | 0.532399788858771 | 0.702330308974487 | 0.520376293994664 | 307407.817065559 | 282192.990008148 | 340166.735457239 | 1.95783440606639E7 | 1.89230076526173E7 | 1.15266683074569E7 | 3962115.44279651 | 3474477.32513512 | 6361226.57462356 | 5.1842207663806E7 | 4.48709077668655E7 | 3.18339270889303E7 | 1.10137014373925E7 | 7604177.6415354 | 1.18325057871337E7 |
| P08122 | Collagen alpha-2(IV) chain [OS=Mus musculus] | 526.992 | 64 | 69 | 1077 | 69 | 1707 | 167.2 | RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix | extracellular structural activity | 12827 | ENSMUSG00000031503 | Col4a2 | mmu:12827; P08122; Q3B7C2; Q3TPV9; Q61375; Q66JS5; Q6RCT6; Q6RCT7; Q6U9X1; Q8BPI9; Q8BPK3; Q91VI3 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Focal adhesion | Laminin interactions; Signaling by PDGF; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions | 7.029 | 2.876 | 10.91 | 3.309 | 1.603 | 3.934 | 1.208 | 3.852 | 0.352816378116182 | 0.64759425713406 | 0.293387877727491 | 0.79866917976589 | 0.979628232635575 | 0.169673447599406 | 0.959159975702413 | 0.483015668880262 | 1499335.01530309 | 1691518.00623855 | 989751.415380184 | 5.53234274481973E7 | 5.88619201086468E7 | 3.63990683013196E7 | 1.35123643610626E7 | 1.30555597235297E7 | 1.53773176128868E7 | 6.80333035906639E7 | 6.55922447276284E7 | 4.55601360762201E7 | 1.71661195678148E7 | 9511844.25395737 | 2.43703078917008E7 |
| Q3U962 | Collagen alpha-2(V) chain [OS=Mus musculus] | 518.514 | 64 | 57 | 817 | 55 | 1497 | 144.9 | cell organization and biogenesis;developmental processes;other biological processes | extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12832 | ENSMUSG00000026042 | Col5a2 | mmu:12832; Q3TVR2; Q3U962; Q3UHK7; Q3UTT4; Q3V1J6; Q61431; Q7TMS0; Q80VS8 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions | 1.598 | 1.546 | 1.519 | 1.021 | 0.385 | 3.505 | 0.525 | 2.477 | 0.861384746267066 | 0.961254912149485 | 0.730324052254867 | 0.632833892117728 | 0.0769666553885184 | 0.273444295895674 | 0.453486790198347 | 0.973358018692255 | 1.96082795853326E7 | 1.89754303457921E7 | 3.46758133166589E7 | 4.80275081428664E7 | 4.79991185130461E7 | 4.1747532446715E7 | 1.59204573672189E7 | 1.42782577106181E7 | 1.7061559679881E7 | 2.09575588581227E7 | 1.96948053072084E7 | 2.25862916575107E7 | 1.85137908486988E7 | 4881772.8383399 | 8018525.34642114 |
| Q05793 | Basement membrane-specific heparan sulfate proteoglycan core protein [OS=Mus musculus] | 507.28 | 33 | 84 | 998 | 84 | 3707 | 398 | cell organization and biogenesis;transport;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;ER/Golgi | other molecular function | 15530 | Hspg2 | mmu:15530; Q05793 | 7.351 | 4.161 | 3.918 | 5.169 | 0.496 | 1.868 | 0.437 | 2.1 | 0.332090710292395 | 0.382764581022518 | 0.771134174410141 | 0.553652046981626 | 0.208890689478245 | 0.938381933295379 | 0.285967432697218 | 0.908661395894721 | 136795.508290338 | 206406.403199821 | 169825.859706297 | 3.70110206606215E7 | 4.34630743166815E7 | 4.28074794537461E7 | 2.41165287907714E7 | 1.91842080304052E7 | 2.07659482289725E7 | 2.10452863152835E7 | 2.06741361608803E7 | 1.52751209810576E7 | 8226367.86740312 | 5927226.99682882 | 1.0580617159021E7 | |||
| Q61554 | Fibrillin-1 [OS=Mus musculus] | 499.202 | 38 | 86 | 1117 | 86 | 2873 | 312.1 | cell adhesion;other metabolic processes;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 14118 | ENSMUSG00000027204 | Fbn1 | A2AQ53; mmu:14118; Q60826; Q61554 | Comprehensive IL-17A signaling | Integrin cell surface interactions; Degradation of the extracellular matrix; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; TGF-beta receptor signaling activates SMADs; Molecules associated with elastic fibres | 18.996 | 8.247 | 8.911 | 3.018 | 0.396 | 2.1 | 0.276 | 3.153 | 0.0596853092747711 | 0.0840496117897429 | 0.378389090130589 | 0.84258396038376 | 0.087482121441914 | 0.862063111456553 | 0.0455630470425967 | 0.77820123247099 | 95282.9912894267 | 109686.773968107 | 40225.7464170883 | 5.82457893686458E7 | 6.62931141873392E7 | 3.19536333419291E7 | 2.33066180631659E7 | 1.9035713753758E7 | 2.29784126659734E7 | 2.39841959808407E7 | 2.29999435869113E7 | 1.54925740961197E7 | 5514536.56061601 | 2575605.08863811 | 7345083.32475891 |
| Q8BTM8 | Filamin-A [OS=Mus musculus] | 493.069 | 49 | 91 | 915 | 83 | 2647 | 281 | cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;other molecular function | 192176 | ENSMUSG00000031328 | Flna | B7FAV0; O54934; Q7TQI1; Q8BLK1; Q8BTM8; Q8BTN7; Q8VHX5; Q8VHX8; Q99KQ2 | Mapk signaling pathway; Focal adhesion | Platelet degranulation ; Cell-extracellular matrix interactions; RHO GTPases activate PAKs; GP1b-IX-V activation signalling | 16.184 | 3.535 | 15.745 | 4.108 | 1.303 | 2.08 | 0.901 | 2.899 | 0.0844935092512095 | 0.493514006575528 | 0.170420349138264 | 0.67528135146603 | 0.946239447314336 | 0.864215513767001 | 0.904360680536565 | 0.8468455705593 | 223080.302738683 | 192779.021360071 | 239583.24348992 | 1.21506602248127E7 | 1.23160583881327E7 | 9719435.76620134 | 4325195.00464495 | 4176073.86658823 | 6355593.34436329 | 1.73054238441738E7 | 1.42527501066511E7 | 1.24998953996761E7 | 4531038.34565544 | 2879720.55833739 | 5479053.39146785 |
| P02463 | Collagen alpha-1(IV) chain [OS=Mus musculus] | 487.707 | 70 | 68 | 828 | 68 | 1669 | 160.6 | cell organization and biogenesis;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix | extracellular structural activity;other molecular function | 12826 | ENSMUSG00000031502 | Col4a1 | mmu:12826; P02463; Q3UHJ4; Q3UJE7; Q3UQV2; Q53X35; Q6GQS7; Q6PHB5; Q99LQ8 | Spinal cord injury; Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Laminin interactions; Signaling by PDGF; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions | 4.371 | 1.004 | 11.171 | 2.458 | 3.498 | 3.947 | 1.69 | 4.683 | 0.604225174343649 | 0.68008321917751 | 0.284160251285083 | 0.936818656936794 | 0.483508479481234 | 0.167300285011781 | 0.777395712279767 | 0.224623005929948 | 359769.877634713 | 285958.835932462 | 141085.539092917 | 2.00868956379824E7 | 2.17854047157598E7 | 2.25190928918174E7 | 4657081.16483192 | 4119739.1632835 | 5084724.84322114 | 3.91843343162395E7 | 3.69562703398771E7 | 2.33283395840594E7 | 7286914.931104 | 6193195.94075903 | 1.32557370999003E7 |
| Q60847 | Collagen alpha-1(XII) chain [OS=Mus musculus] | 480.266 | 40 | 95 | 991 | 95 | 3120 | 340 | cell adhesion;developmental processes | other cell component | 12816 | ENSMUSG00000032332 | Col12a1 | mmu:12816; P70322; Q60847 | Assembly of collagen fibrils and other multimeric structures; Collagen chain trimerization; Collagen degradation | 15.041 | 20 | 9.674 | 12.612 | 0.427 | 0.631 | 0.21 | 1.243 | 0.0975092237649803 | 1.8644578313253E-17 | 0.344512840834051 | 0.162753188077458 | 0.119424004207039 | 0.101350980560035 | 0.0103905836841461 | 0.266844028199729 | 98450.5264125119 | 58090.3600627237 | 83999.6481680613 | 3.34408474370425E7 | 3.89438836318894E7 | 1.74727378978336E7 | 5.74848700994307E7 | 4.49447732262548E7 | 5.27793485517261E7 | 1.71723257401258E7 | 1.50709974901674E7 | 1.16453026750935E7 | 1.0899125462023E7 | 6848854.24799245 | 1.38653609093446E7 | ||
| Q8VDD5 | Myosin-9 [OS=Mus musculus] | 418.364 | 45 | 73 | 827 | 60 | 1960 | 226.2 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;stress response;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;other molecular function | 17886 | ENSMUSG00000022443 | Myh9 | mmu:17886; Q3UHT9; Q3UHU4; Q6KAN6; Q811I2; Q8VDD5 | Primary focal segmental glomerulosclerosis (FSGS) | RHO GTPases activate PAKs; Regulation of actin dynamics for phagocytic cup formation | 11.694 | 10.853 | 19.492 | 13.21 | 2.21 | 1.427 | 1.339 | 2.347 | 0.156498497144098 | 0.0382609387499984 | 0.118876667035285 | 0.15125389278925 | 0.87421335771164 | 0.916542675526027 | 0.91728043005175 | 0.990873516209569 | 107483.529676039 | 153800.887463573 | 39674.4269878413 | 8783012.74886087 | 9974545.70796386 | 5444477.78467149 | 4748384.28257292 | 4410554.6604061 | 6370665.87897293 | 2.10207699044932E7 | 2.09758895852136E7 | 1.72823293907493E7 | 8538625.93793802 | 5517905.75659883 | 9476865.41359831 |
| Cont_P02453 | Collagen alpha-1(I) chain OS=Bos taurus OX=9913 GN=COL1A1 PE=1 SV=3 | 414.689 | 43 | 43 | 1208 | 4 | 1463 | 138.9 | cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | 282187 | ENSBTAG00000013103 | COL1A1 | bta:282187; P02453; Q3MHM2 | Inflammatory response pathway; Osteoblast signaling; Focal adhesion | Fibronectin matrix formation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Collagen degradation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; Collagen chain trimerization; GPVI-mediated activation cascade; Platelet Aggregation (Plug Formation); Platelet Adhesion to exposed collagen; GP1b-IX-V activation signalling | 1.443 | 0.869 | 1.124 | 1.501 | 0.374 | 1.284 | 0.335 | 0.775 | 0.800889767710788 | 0.579410556046386 | 0.58548007712969 | 0.839216523231753 | 0.067749585016969 | 0.848119069115724 | 0.108042253370914 | 0.0107964100780951 | 246464.336302772 | 276104.509600215 | 163058.776827813 | 4343807.62117337 | 4270443.00602544 | 3115927.46864821 | 3219828.72869598 | 3183952.03023541 | 3383679.40073467 | 941743.224351002 | 1075861.66368366 | 756862.710693879 | 1364509.18546901 | 876331.391932507 | 1065336.29340721 |
| Cont_P02769 | Albumin OS=Bos taurus OX=9913 GN=ALB PE=1 SV=4 | 390.555 | 81 | 57 | 7095 | 54 | 607 | 69.2 | stress response;other biological processes | non-structural extracellular;other cell component | nucleic acid binding activity;other molecular function | 280717 | ALB | A5PJX3; bta:280717; O02787; P02769; P04277; Q3SZR2 | 0.86 | 0.957 | 1.154 | 0.79 | 1.314 | 0.876 | 0.791 | 1.45 | 0.520832629933248 | 0.650544967914241 | 0.598172767155558 | 0.497906326712893 | 0.946568086066385 | 0.413798631523592 | 0.846117085258013 | 0.468531677746422 | 3.41035277502904E9 | 3.06531085647989E9 | 1.66716629813739E9 | 2.0547979326133E9 | 2.37062763488737E9 | 2.78500610382043E9 | 3.09362764542436E9 | 2.55631644026836E9 | 3.07992745656962E9 | 2.97814649224141E9 | 2.86277256421772E9 | 2.21144220575444E9 | 1.66052966718895E9 | 2.22855277531216E9 | 3.25384623573346E9 | |||
| P01027 | Complement C3 [OS=Mus musculus] | 388.541 | 53 | 70 | 1148 | 62 | 1663 | 186.4 | cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular;other cell component | signal transduction activity or receptor binding;enzyme regulator activity | 12266 | ENSMUSG00000024164 | C3 | mmu:12266; P01027; Q61370; Q80XP1 | Complement activation, classical pathway; Tyrobp causal network in microglia; Comprehensive IL-17A signaling | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade; Neutrophil degranulation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; G alpha (i) signalling events; Peptide ligand-binding receptors; Alternative complement activation; Activation of C3 and C5 | 3.547 | 2.537 | 6.803 | 3.529 | 1.878 | 2.911 | 2.425 | 2.35 | 0.712660037675161 | 0.729783028721347 | 0.506101547380209 | 0.762068821001752 | 0.939492000987438 | 0.512232143465318 | 0.413470300505934 | 0.991722673088443 | 4040096.73815256 | 3926631.83282415 | 1843021.41157313 | 4.04154698805798E7 | 4.4896658832648E7 | 4.8335201547635E7 | 1.80671896153384E7 | 1.47828809765086E7 | 1.7121367805152E7 | 9.88883606977539E7 | 8.1974398309486E7 | 5.99376709525504E7 | 3.21393016835685E7 | 2.84159228355073E7 | 4.96444404075474E7 |
| Cont_Q7SIH1 | Alpha-2-macroglobulin OS=Bos taurus OX=9913 GN=A2M PE=1 SV=2 | 370.864 | 53 | 56 | 1089 | 56 | 1510 | 167.5 | non-structural extracellular | enzyme regulator activity;other molecular function | 513856 | ENSBTAG00000018137 | A2M | A8E647; bta:513856; Q7SIH1 | IL-6 signaling pathway | 1.169 | 1.273 | 1.523 | 0.809 | 1.276 | 0.967 | 0.649 | 1.845 | 0.688450665125024 | 0.839052280267302 | 0.731111241255251 | 0.509007335932165 | 0.944154202827561 | 0.540124873725708 | 0.671798309985569 | 0.809503222445875 | 5.71770657169572E7 | 6.35766951637367E7 | 4.19549690627817E7 | 6.46032237401637E7 | 7.37926671048822E7 | 7.2164410166051E7 | 8.06000315293491E7 | 7.23429494984619E7 | 7.40068576999505E7 | 8.7810317845685E7 | 9.50258669209954E7 | 6.46884849507494E7 | 4.10565401116459E7 | 3.96461495018234E7 | 7.63451634810678E7 | ||
| Cont_Q29443 | Serotransferrin OS=Bos taurus OX=9913 GN=TF PE=2 SV=1 | 343.183 | 74 | 48 | 1709 | 46 | 704 | 77.7 | stress response;transport;other biological processes | non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle | other molecular function | 280705 | TF | bta:280705; Q0IIK2; Q29443 | 1.017 | 1.563 | 1.16 | 0.912 | 1.118 | 0.635 | 0.55 | 1.293 | 0.615274986253429 | 0.964709887217926 | 0.600414647182016 | 0.571407162236119 | 0.902231721267411 | 0.105569810421019 | 0.506704636011438 | 0.313748671859839 | 1.71679936327392E8 | 1.91001417946965E8 | 8.41149187199369E7 | 1.24867801818358E8 | 1.55146358811954E8 | 1.88178132242021E8 | 2.69795837029218E8 | 2.21755859229163E8 | 2.04768415701638E8 | 1.81082969779594E8 | 1.61167381210782E8 | 1.45463022007429E8 | 9.18433757916485E7 | 1.38609619584445E8 | 1.76572700073531E8 | |||
| Cont_P07589 | Fibronectin OS=Bos taurus OX=9913 GN=FN1 PE=1 SV=4 | 337.517 | 26 | 47 | 923 | 11 | 2478 | 272 | cell adhesion;cell organization and biogenesis;stress response;developmental processes;other biological processes | non-structural extracellular | signal transduction activity or receptor binding;other molecular function | FN1 | P07589 | 3.52 | 3.363 | 2.311 | 1.395 | 0.714 | 1.039 | 0.476 | 1.31 | 0.714071857030863 | 0.525827426782658 | 0.94971810013306 | 0.802863674292211 | 0.553450172742796 | 0.634088329627404 | 0.35834247597224 | 0.281927255363179 | 142865.797461343 | 209169.389049115 | 146732.075795441 | 1055759.20189889 | 1052518.92691246 | 748231.640959004 | 927817.269350189 | 797644.80797335 | 782189.414628216 | 683356.768802769 | 735882.167003896 | 388557.285212602 | 606468.327162644 | 334439.098432858 | 506951.879121439 | ||||
| Q80X90 | Filamin-B [OS=Mus musculus] | 335.882 | 38 | 75 | 608 | 66 | 2602 | 277.7 | cell organization and biogenesis;stress response;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 286940 | ENSMUSG00000025278 | Flnb | E9QNV9; mmu:286940; Q80X90; Q8VHX4; Q8VHX7; Q99KY3 | ISG15 antiviral mechanism | 7.928 | 5.332 | 12.124 | 4.491 | 1.209 | 1.979 | 0.842 | 2.845 | 0.296944306247309 | 0.238365792894698 | 0.254729742039053 | 0.629546282386664 | 0.936411452199724 | 0.897564267605108 | 0.872448101434609 | 0.866446545996913 | 201569.562939035 | 74814.3999578854 | 187488.727848728 | 5908241.65562211 | 7025090.54357015 | 5213153.27323614 | 2307098.04671866 | 1545558.91097354 | 3200680.70273347 | 8948631.41531232 | 7437294.37435051 | 6391778.7211006 | 1867290.64861647 | 1318356.62479586 | 2409815.97001446 | |
| Cont_P35527 | Keratin, type I cytoskeletal 9 OS=Homo sapiens OX=9606 GN=KRT9 PE=1 SV=3 | 310.424 | 69 | 35 | 915 | 34 | 623 | 62 | cell organization and biogenesis;other biological processes | cytosol;cytoskeleton | cytoskeletal activity | 3857 | ENSG00000171403 | KRT9 | hsa:3857; O00109; P35527; Q0IJ47; Q14665 | Formation of the cornified envelope | 1.535 | 1.081 | 1.647 | 2.287 | 1.044 | 1.471 | 2.208 | 0.777 | 0.836660982916281 | 0.73072258897653 | 0.769556732848094 | 0.964570089320365 | 0.873609880131656 | 0.936669139837906 | 0.516448827835279 | 0.0110179641295352 | 3.00988862408693E7 | 2.22166955848562E7 | 3.53566605858277E7 | 3.83413938796298E7 | 4.01115354911529E7 | 4.55013850626263E7 | 3.25056930591839E7 | 3.99576081794461E7 | 2.50556157717982E7 | 4.79768166310243E7 | 2.93517742058567E7 | 7.69722436015544E7 | 1.31711700890849E8 | 9.27838604678364E7 | 5.6604390657593E7 | |
| Cont_P04264 | Keratin, type II cytoskeletal 1 OS=Homo sapiens OX=9606 GN=KRT1 PE=1 SV=6 | 306.58 | 65 | 45 | 1774 | 36 | 644 | 66 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;other molecular function | 3848 | ENSG00000167768 | KRT1 | B2RA01; hsa:3848; P04264; P85925; P86104; Q14720; Q6GSJ0; Q9H298 | Corticotropin-releasing hormone signaling | Formation of the cornified envelope; Neutrophil degranulation; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 1.103 | 0.963 | 1.229 | 2.667 | 1.042 | 1.184 | 2.925 | 0.472 | 0.65780924735352 | 0.653826967689551 | 0.631165145316661 | 0.89629386854896 | 0.873609880131656 | 0.770634810212039 | 0.254077056479593 | 5.78940441291519E-5 | 1.31038801811221E8 | 1.49848314576813E8 | 1.81048519054156E8 | 1.64179912336924E8 | 1.70861004616453E8 | 1.60803236136221E8 | 1.32005397364365E8 | 1.61355773356369E8 | 1.09071204525108E8 | 1.84835731298625E8 | 1.38277867637903E8 | 2.0582953187505E8 | 6.47574942932283E8 | 3.95085049343759E8 | 3.00261678765842E8 |
| P06909 | Complement factor H [OS=Mus musculus] | 292.01 | 49 | 41 | 540 | 41 | 1234 | 139 | cell adhesion;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes | non-structural extracellular;plasma membrane;other membranes;mitochondrion;other cell component | other molecular function | 12628 | ENSMUSG00000026365 | Cfh | mmu:12628; P06909; Q6NZK3 | Regulation of Complement cascade | 10 | 11.089 | 20 | 8.058 | 2.955 | 0.961 | 0.704 | 3.964 | 0.205200089226065 | 0.0359547312524068 | 1.50457038391225E-17 | 0.329485122608543 | 0.678323397545056 | 0.532399788858771 | 0.750662231008662 | 0.443116920082088 | 45833.2314948132 | 5719.34924483144 | 127074.400703141 | 9199603.23733176 | 9631512.57691777 | 1.22513356989878E7 | 1.13946236540082E7 | 8948376.12127358 | 1.13575209573925E7 | 3.40837407850627E7 | 2.84575354110008E7 | 2.55312981422866E7 | 7658800.41775084 | 6857257.31092971 | 1.08034871236965E7 | |
| P16546 | Spectrin alpha chain, non-erythrocytic 1 [OS=Mus musculus] | 291.854 | 35 | 74 | 473 | 74 | 2472 | 284.4 | cell organization and biogenesis | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 20740 | ENSMUSG00000057738 | Sptan1 | A3KGU6; A3KGU8; P16546; Q8K380; Q9CT05 | FAS pathway and stress induction of HSP regulation | Neutrophil degranulation; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Interaction between L1 and Ankyrins; COPI-mediated anterograde transport; RHOU GTPase cycle; RHOV GTPase cycle; Caspase-mediated cleavage of cytoskeletal proteins | 2.273 | 1.172 | 5.466 | 1.689 | 1.972 | 2.321 | 1.488 | 2.88 | 0.958962194559628 | 0.786160319109602 | 0.611910908670005 | 0.890289034593217 | 0.929383260195332 | 0.771887919257916 | 0.870511801558508 | 0.852906094467594 | 889916.065158961 | 705414.766907556 | 458549.490375553 | 4175162.43226982 | 4600176.71769719 | 3155429.78771999 | 1301153.76848032 | 907755.21332001 | 2072924.21437361 | 9282178.93349268 | 8610756.12905297 | 6522130.81446154 | 2340149.67970916 | 1477626.07784989 | 2972528.81421804 |
| Cont_P13645 | Keratin, type I cytoskeletal 10 OS=Homo sapiens OX=9606 GN=KRT10 PE=1 SV=6 | 286.713 | 62 | 30 | 1322 | 20 | 584 | 58.8 | cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes | plasma membrane;cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;other molecular function | 3858 | ENSG00000186395 | KRT10 | hsa:3858; P13645; Q14664; Q8N175 | Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.992 | 0.771 | 1.072 | 2.427 | 0.958 | 1.365 | 2.951 | 0.443 | 0.600890052902075 | 0.490821286240141 | 0.561934876627864 | 0.941696908693733 | 0.829734761131295 | 0.880940844456856 | 0.246231694954624 | 2.55433624902191E-5 | 8.57039306780817E7 | 1.2308209015436E8 | 1.23973335952419E8 | 1.09050331614224E8 | 1.30109606828786E8 | 1.02692161896587E8 | 8.73473050095944E7 | 1.23031831133367E8 | 7.19147674496861E7 | 1.29238189237995E8 | 9.43248217623685E7 | 1.03859326412487E8 | 5.11249836753994E8 | 2.4676744393623E8 | 2.01230291385254E8 | |
| Cont_P35908 | Keratin, type II cytoskeletal 2 epidermal OS=Homo sapiens OX=9606 GN=KRT2 PE=1 SV=2 | 284.975 | 78 | 42 | 1022 | 32 | 639 | 65.4 | cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes | plasma membrane;cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;cytoskeletal activity | 3849 | ENSG00000172867 | KRT2 | hsa:3849; P35908; Q4VAQ2 | Formation of the cornified envelope | 0.827 | 0.688 | 1.032 | 1.836 | 1.146 | 1.306 | 2.733 | 0.542 | 0.499413631103761 | 0.411258958244596 | 0.544106843431104 | 0.933570718645937 | 0.912218866069753 | 0.862063111456553 | 0.309041843038519 | 2.9837536993241E-4 | 2.56957016834685E7 | 6.51011422173888E7 | 5.25056794690703E7 | 3.16465014359267E7 | 4.04662454773149E7 | 3.03458785296059E7 | 2.58420950665494E7 | 4.44581259999837E7 | 1.77732081549674E7 | 3.88601529372083E7 | 2.41897353529024E7 | 4.54682916268081E7 | 9.79668081708945E7 | 6.73715830359901E7 | 6.38856203067551E7 | |
| Q62059 | Versican core protein [OS=Mus musculus] | 279.715 | 17 | 44 | 1073 | 44 | 3357 | 366.6 | cell adhesion;developmental processes | non-structural extracellular;extracellular matrix;other cell component | other molecular function | Vcan | Q62058; Q62059; Q9CUU0 | ECM proteoglycans; Glycosaminoglycan-protein linkage region biosynthesis; CS/DS degradation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; CS-GAG biosynthesis; DS-GAG biosynthesis | 20 | 20 | 20 | 20 | 1.005 | 1.018 | 0.536 | 1.805 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.854305439376382 | 0.613304974369123 | 0.478009151463064 | 0.783304059803245 | 125473.726574878 | 146060.097046071 | 41031.8651630982 | 8.44868881898379E7 | 1.01917408783468E8 | 9.76252353450265E7 | 1.00104936351016E8 | 8.17450473009677E7 | 8.92610512588614E7 | 1.04839173391366E8 | 1.06605513712809E8 | 7.38631920533055E7 | 5.09261453344577E7 | 4.44571187520766E7 | 8.14544543672178E7 | |||
| P10493 | Nidogen-1 [OS=Mus musculus] | 275.191 | 43 | 42 | 852 | 42 | 1245 | 136.5 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | other molecular function | 18073 | ENSMUSG00000005397 | Nid1 | mmu:18073; P10493; Q3TKX9; Q8BQI3; Q8C3U8; Q8C9P6 | Laminin interactions; Degradation of the extracellular matrix | 20 | 20 | 12.26 | 6.185 | 0.272 | 1.009 | 0.083 | 3.135 | 1.65082956259427E-17 | 1.8644578313253E-17 | 0.251140212279038 | 0.461941385639594 | 0.013229256333524 | 0.604382524464811 | 1.0740690550749E-5 | 0.781368126060588 | 439897.722361698 | 266111.080129006 | 261357.080833752 | 1.30583493944604E8 | 1.41493313555848E8 | 1.08068734992402E8 | 1.1764867041349E8 | 1.23903817347262E8 | 1.22059347123012E8 | 3.85653673006923E7 | 3.40794335543811E7 | 2.32700802472122E7 | 8950100.03941293 | 6809358.71273179 | 1.16807558295498E7 | |
| O88207 | Collagen alpha-1(V) chain [OS=Mus musculus] | 275.025 | 46 | 52 | 413 | 44 | 1838 | 183.6 | cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes | extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12831 | ENSMUSG00000026837 | Col5a1 | A3KGE3; mmu:12831; O88207; Q3UG94; Q6F6B0 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | ECM proteoglycans; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; MET activates PTK2 signaling | 20 | 20 | 11.658 | 8.419 | 0.482 | 2.145 | 0.446 | 1.84 | 1.65082956259427E-17 | 1.8644578313253E-17 | 0.268653947705267 | 0.311207075116757 | 0.189625712887896 | 0.848119069115724 | 0.302671730722046 | 0.809503222445875 | 12502.6007438316 | 105962.872602761 | 122701.039249758 | 8585864.47184676 | 9052435.86465399 | 8047799.6262338 | 3715509.90739661 | 3183478.03245453 | 3834509.14396516 | 3548034.64380386 | 3694879.64301103 | 2052789.86607006 | 1322438.93167649 | 910135.702053452 | 1926767.56075777 |
| P37889 | Fibulin-2 [OS=Mus musculus] | 269.894 | 43 | 37 | 791 | 37 | 1221 | 131.7 | other biological processes | non-structural extracellular | other molecular function | 14115 | ENSMUSG00000064080 | Fbln2 | G5E8B3; mmu:14115; P37889; Q9WUI2 | Molecules associated with elastic fibres | 20 | 9.095 | 14.207 | 9.595 | 0.657 | 1.229 | 0.44 | 1.856 | 1.65082956259427E-17 | 0.0640195441309023 | 0.201227492083465 | 0.255240026777032 | 0.453005417011507 | 0.803447472095846 | 0.290132264062119 | 0.809503222445875 | 404936.27628206 | 303410.824570497 | 379728.902265123 | 7.35240092421165E7 | 8.16716617206073E7 | 8.54486063918813E7 | 7.34239875271171E7 | 6.18846762513378E7 | 6.13955038440774E7 | 5.64407337496573E7 | 5.35180097543675E7 | 3.80873889057723E7 | 2.96696416762988E7 | 2.21115750486307E7 | 3.84218730879294E7 | |
| Q8VHX6 | Filamin-C [OS=Mus musculus] | 249.498 | 31 | 65 | 425 | 56 | 2726 | 290.9 | cell organization and biogenesis;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity | 68794 | ENSMUSG00000068699 | Flnc | B2RY80; B9EKT2; mmu:68794; Q6PAI6; Q8VHX6; Q9JJ38 | Cell-extracellular matrix interactions | 0.924 | 1.063 | 2.364 | 0.915 | 1.621 | 1.781 | 0.941 | 3.029 | 0.562594032195739 | 0.719627996749639 | 0.962331548063155 | 0.57290809187594 | 0.976873891151678 | 0.96786708205164 | 0.933437821008547 | 0.80954066750699 | 362673.376414211 | 453714.7830589 | 401875.758519269 | 2896613.16388353 | 1997446.07055639 | 1374740.24453431 | 898320.393102247 | 899851.262035181 | 1251187.76236098 | 4619845.64928082 | 4224920.76413233 | 4533386.9985568 | 889222.28002913 | 1245417.60281572 | 1275359.84004796 | |
| Q04857 | Collagen alpha-1(VI) chain [OS=Mus musculus] | 248.981 | 44 | 33 | 588 | 33 | 1025 | 108.4 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component | other molecular function | 12833 | ENSMUSG00000001119 | Col6a1 | mmu:12833; Q04857 | ECM proteoglycans; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Signaling by PDGF; NCAM1 interactions | 8.793 | 4.087 | 2.364 | 2.258 | 0.328 | 1.748 | 0.341 | 1.364 | 0.2534363617947 | 0.392208211277376 | 0.962331548063155 | 0.971216996811237 | 0.0353343473113635 | 0.97504218639442 | 0.115965329440656 | 0.380888676065133 | 99442.7570537982 | 67304.0023261046 | 63848.8638629308 | 6.50338448192604E7 | 8.11264443817216E7 | 6.12675161034549E7 | 5.28406132873544E7 | 4.53711044962942E7 | 5.19951028566589E7 | 2.08305860584001E7 | 2.24322225654869E7 | 1.63957751491443E7 | 1.39653990737858E7 | 1.00181099527419E7 | 1.94360212112643E7 | |
| Cont_Q2UVX4 | Complement C3 OS=Bos taurus OX=9913 GN=C3 PE=1 SV=2 | 247.154 | 39 | 55 | 851 | 47 | 1661 | 187.1 | cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular;other cell component | signal transduction activity or receptor binding;enzyme regulator activity | 280677 | ENSBTAG00000017280 | C3 | bta:280677; Q2KIZ4; Q2UVX4 | Complement and coagulation cascades; Complement activation, classical pathway | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Neutrophil degranulation; Peptide ligand-binding receptors; G alpha (i) signalling events; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade; Alternative complement activation; Activation of C3 and C5 | 1.019 | 1.197 | 1.097 | 0.804 | 1.068 | 0.796 | 0.594 | 1.431 | 0.615680953989958 | 0.798729234704005 | 0.573945385766997 | 0.506364847510615 | 0.87421335771164 | 0.291700662163587 | 0.591028379533681 | 0.448532796991499 | 1.66248121121728E7 | 1.69271139045693E7 | 1.05083515570206E7 | 1.25526666866144E7 | 1.76991579704635E7 | 1.56235874907449E7 | 1.80944158276855E7 | 1.82336027421103E7 | 1.90370193770683E7 | 1.87583360164926E7 | 1.78001813666833E7 | 1.18248646641963E7 | 8899645.14317005 | 9025681.5960692 | 1.79617171787325E7 |
| Q62261 | Spectrin beta chain, non-erythrocytic 1 [OS=Mus musculus] | 244.684 | 30 | 61 | 398 | 61 | 2363 | 274.1 | cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 20742 | ENSMUSG00000020315 | Sptbn1 | A2AFU1; mmu:20742; Q3TEM7; Q5SQL8; Q5SQL9; Q62261; Q9QWJ7 | COPI-mediated anterograde transport; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; RHOU GTPase cycle; Interaction between L1 and Ankyrins; RHOV GTPase cycle | 1.181 | 1.156 | 1.412 | 1.471 | 1.95 | 2.087 | 1.904 | 2.22 | 0.69394578118832 | 0.776437620310661 | 0.693719649766064 | 0.831411077141515 | 0.937876734191067 | 0.86315143463057 | 0.664971370235365 | 0.953305976192702 | 373834.445440549 | 533726.562973047 | 569801.107945045 | 3103526.47805657 | 3181731.16602619 | 2477755.42998989 | 796281.087102098 | 609431.872132576 | 1356947.15467432 | 7745784.08821259 | 6610112.71623617 | 4897418.35730506 | 2432765.02616441 | 1743474.26371724 | 2723698.32906552 | |
| Q640N1 | Adipocyte enhancer-binding protein 1 [OS=Mus musculus] | 239.707 | 38 | 34 | 648 | 34 | 1128 | 128.3 | protein metabolism;other biological processes | nucleus;other cell component | nucleic acid binding activity;other molecular function | 11568 | ENSMUSG00000020473 | Aebp1 | mmu:11568; O88442; Q3TVV5; Q3TWA7; Q3TX56; Q3TXB2; Q5NCI9; Q61281; Q640N1 | 8.459 | 10.223 | 5.53 | 4.478 | 0.703 | 1.165 | 0.36 | 2.258 | 0.269326617826563 | 0.0457359864845759 | 0.605387748357992 | 0.631359014803774 | 0.534291750451691 | 0.760992448481534 | 0.145805028390539 | 0.963436677882021 | 3560033.84712119 | 4696620.34449178 | 6275149.80645163 | 4.59930845855363E7 | 5.69735867783534E7 | 2.04646374454636E7 | 3.80233154774145E7 | 4.02615711999708E7 | 4.03854487434811E7 | 3.40966164303398E7 | 3.7490792004469E7 | 2.41166240785119E7 | 1.4983671743246E7 | 1.40971982755857E7 | 2.68643149803103E7 | ||
| P57780 | Alpha-actinin-4 [OS=Mus musculus] | 239.42 | 58 | 45 | 483 | 30 | 912 | 104.9 | cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes | cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 60595 | ENSMUSG00000054808 | Actn4 | mmu:60595; P57780 | Primary focal segmental glomerulosclerosis (FSGS) | Platelet degranulation | 20 | 20 | 20 | 11.478 | 1.18 | 2.264 | 1.041 | 2.59 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 0.19149089837131 | 0.921882153462399 | 0.795351011232032 | 0.968364585136618 | 0.938282411159324 | 5221.79731213346 | 36578.541519335 | 9107610.67207618 | 1.00453975465233E7 | 1.03378326393571E7 | 5095419.11923033 | 3409382.50707632 | 5238186.41277381 | 1.31020350186557E7 | 1.2711162036506E7 | 9162046.18669404 | 4501757.36231035 | 3002316.05426355 | 5816939.08777499 | |
| Q7TPR4 | Alpha-actinin-1 [OS=Mus musculus] | 235.529 | 54 | 42 | 511 | 27 | 892 | 103 | cell adhesion;cell organization and biogenesis;other biological processes | plasma membrane;other membranes;cytoskeleton;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function | 109711 | ENSMUSG00000015143 | Actn1 | mmu:109711; Q7TPR4 | Regulation of actin cytoskeleton; Integrin-mediated cell adhesion; Focal adhesion | Platelet degranulation ; RHOF GTPase cycle; RHOBTB2 GTPase cycle; RHOD GTPase cycle; Regulation of cytoskeletal remodeling and cell spreading by IPP complex components | 2.068 | 0.45 | 1.822 | 2.422 | 1.639 | 2.396 | 1.586 | 2.793 | 0.995554138371554 | 0.178726136005694 | 0.819280225722906 | 0.941696908693733 | 0.974207409660283 | 0.744084716394381 | 0.837231569641376 | 0.879972045955715 | 354073.059499792 | 209249.076355465 | 897084.460899514 | 5526121.35104279 | 6211867.70337129 | 6893436.45630869 | 2413615.48536692 | 1933168.81934458 | 3229981.90899851 | 1.03807818109957E7 | 1.11771340173328E7 | 8282960.99949337 | 3416305.89125481 | 2797115.44078374 | 4939050.64701654 |
| P02468 | Laminin subunit gamma-1 [OS=Mus musculus] | 230.882 | 35 | 43 | 454 | 43 | 1607 | 177.2 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | Lamc1 | P02468 | 13.572 | 7.288 | 7.506 | 4.094 | 0.559 | 2.029 | 0.482 | 2.135 | 0.118212047511996 | 0.116315527815218 | 0.459134305737471 | 0.675951294045723 | 0.3041568870489 | 0.877818946381645 | 0.368062651583427 | 0.922276466908065 | 14325.5972836352 | 21883.5466161272 | 1.5357350900924E7 | 1.57310961044729E7 | 1.74335709018572E7 | 7496762.71625721 | 6775968.90045745 | 7708775.93718172 | 9245241.37337628 | 9035989.05815721 | 5573559.97495901 | 2765122.91380764 | 2368540.67041914 | 4605215.17131646 | |||||
| Q91ZX7 | Prolow-density lipoprotein receptor-related protein 1 [OS=Mus musculus] | 230.497 | 15 | 57 | 519 | 56 | 4545 | 504.4 | other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;other molecular function | 16971 | Lrp1 | mmu:16971; Q61291; Q91ZX7; Q920Y4 | Statin pathway; Wnt signaling pathway | Scavenging of heme from plasma; Retinoid metabolism and transport | 20 | 13.648 | 18.208 | 13.235 | 0.805 | 1.902 | 0.692 | 2.078 | 1.65082956259427E-17 | 0.0181625429641231 | 0.133639440745791 | 0.150830220548111 | 0.687557067265551 | 0.925871264502428 | 0.74148782464906 | 0.901098484497789 | 10237.2255539891 | 51104.3489937616 | 6875342.47952318 | 6944806.90573824 | 8247481.69257335 | 4299652.1243919 | 2953538.60705284 | 3392031.85738558 | 6405748.2654286 | 5854087.4911046 | 4914685.84613499 | 2044471.2247951 | 1705219.62694462 | 2981142.11204421 | ||
| Cont_P60712 | Actin, cytoplasmic 1 OS=Bos taurus OX=9913 GN=ACTB PE=1 SV=1 | 225.45 | 70 | 19 | 852 | 2 | 375 | 41.7 | cell organization and biogenesis;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component | enzyme regulator activity;cytoskeletal activity;other molecular function | 100033878; 100135470; 100173832; 101844587; 102139853; 11461; 118833809; 280979; 396526; 403580; 414396; 443052; 450133; 60; 81822 | ENSBTAG00000026199; ENSCAFG00000016020; ENSCAFG00030015381; ENSCAFG00040015695; ENSCPOG00000013467; ENSG00000075624; ENSMAUG00000008763; ENSMUSG00000029580; ENSOARG00040012985; ENSOARG00180022443; ENSOARG00185023855; ENSOARG00215030140; ENSOARG00225009314; ENSPPYG00000017336; ENSPTRG00000018890; ENSRNOG00000034254; ENSSSCG00000007585; ENSSSCG00030003451; ENSSSCG00035038792; ENSSSCG00040049462; ENSSSCG00045027458; ENSSSCG00050065025; ENSSSCG00055012597; ENSSSCG00060019124; ENSSSCG00065037921; ENSSSCG00070011353; ENSSSCG00105030144; ENSSSCG00110026965; ENSSSCG00115013637; ENSSSCG00130033784 | Actb; ACTB | A5D961; A5PKA1; bta:280979; cfa:403580; cpoc:100135470; csab:103246953; ecb:100033878; gga:396526; hsa:60; maua:101844587; mmu:11461; O18840; oas:443052; P02570; P60706; P60707; P60708; P60709; P60710; P60711; P60712; P60713; P70514; P99021; pon:100173832; ptr:450133; Q11209; Q11211; Q3SZD2; Q3TI89; Q3TVP6; Q4L0Y2; Q4R561; Q5R1X3; Q5R582; Q5R6G0; Q64316; Q6QAQ1; Q6ZWM3; Q711N9; Q71FK5; Q75MN2; Q76N69; Q8MIJ0; Q8SPX4; Q95164; Q96B34; Q96HG5; rno:81822; ssc:414396 | FAS pathway and stress induction of HSP regulation; Actin cytoskeleton regulation; Myometrial relaxation and contraction pathways; Focal adhesion; Arrhythmogenic right ventricular cardiomyopathy; Pathogenic Escherichia coli infection; Common pathways underlying drug addiction; Myometrial relaxation and contraction pathways; Focal adhesion; Fas ligand pathway and stress induction of heat shock proteins; Pathogenic Escherichia coli infection; Arrhythmogenic right ventricular cardiomyopathy; Focal adhesion; Myometrial relaxation and contraction pathways; Regulation of actin cytoskeleton; Myometrial relaxation and contraction pathways; Ebola virus infection in host; Acute viral myocarditis; Thermogenesis; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Overlap between signal transduction pathways contributing to LMNA laminopathies; Pleural mesothelioma; Regulation of actin cytoskeleton; Network map of SARS-CoV-2 signaling; Regulation of actin cytoskeleton; Regulation of actin cytoskeleton; Focal adhesion | Formation of the canonical BAF (cBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); Regulation of actin dynamics for phagocytic cup formation; EPH-ephrin mediated repulsion of cells; Formation of annular gap junctions; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; RHO GTPases Activate Formins; RHOF GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; B-WICH complex positively regulates rRNA expression; Regulation of CDH1 Function; Formation of the dystrophin-glycoprotein complex (DGC); Formation of the canonical BAF (cBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); RHO GTPases Activate WASPs and WAVEs; UCH proteinases; DNA Damage Recognition in GG-NER; Formation of the non-canonical BAF (ncBAF) complex; RHO GTPases activate IQGAPs; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Cell-extracellular matrix interactions; MAP2K and MAPK activation; Interaction between L1 and Ankyrins; RHOF GTPase cycle; DNA Damage Recognition in GG-NER; MAP2K and MAPK activation; RHO GTPases Activate Formins; Clathrin-mediated endocytosis; UCH proteinases; RHOF GTPase cycle; DNA Damage Recognition in GG-NER; EPH-ephrin mediated repulsion of cells; VEGFA-VEGFR2 Pathway; Regulation of actin dynamics for phagocytic cup formation; Adherens junctions interactions; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); RHO GTPases Activate WASPs and WAVEs; B-WICH complex positively regulates rRNA expression; Regulation of CDH1 Function; EPHB-mediated forward signaling; Formation of the non-canonical BAF (ncBAF) complex; Formation of the canonical BAF (cBAF) complex; Formation of annular gap junctions; RHO GTPases activate IQGAPs; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; RHO GTPases Activate WASPs and WAVEs; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RHO GTPases activate IQGAPs; RHO GTPases Activate Formins; RHOF GTPase cycle; Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs); B-WICH complex positively regulates rRNA expression; Signaling by BRAF and RAF1 fusions; UCH proteinases; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; VEGFA-VEGFR2 Pathway; Formation of the dystrophin-glycoprotein complex (DGC); Factors involved in megakaryocyte development and platelet production; Regulation of MITF-M-dependent genes involved in pigmentation; Formation of the canonical BAF (cBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); EPH-ephrin mediated repulsion of cells; HATs acetylate histones; Interaction between L1 and Ankyrins; Prefoldin mediated transfer of substrate to CCT/TriC; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Adherens junctions interactions; Regulation of CDH1 Function; Formation of the non-canonical BAF (ncBAF) complex; DNA Damage Recognition in GG-NER; Formation of the polybromo-BAF (pBAF) complex; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Formation of annular gap junctions; Folding of actin by CCT/TriC; Cell-extracellular matrix interactions; MAP2K and MAPK activation; RHO GTPases Activate Formins; Recycling pathway of L1; RHO GTPases activate IQGAPs; Clathrin-mediated endocytosis; Formation of the dystrophin-glycoprotein complex (DGC); EPHB-mediated forward signaling; UCH proteinases; B-WICH complex positively regulates rRNA expression; Adherens junctions interactions; Formation of the non-canonical BAF (ncBAF) complex; Formation of annular gap junctions; Formation of the polybromo-BAF (pBAF) complex; VEGFA-VEGFR2 Pathway; Cell-extracellular matrix interactions; RHO GTPases Activate WASPs and WAVEs; Regulation of CDH1 Function; Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; UCH proteinases; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); Formation of the polybromo-BAF (pBAF) complex; B-WICH complex positively regulates rRNA expression; DNA Damage Recognition in GG-NER; Formation of the canonical BAF (cBAF) complex; RHO GTPases Activate Formins; Regulation of CDH1 Function; Interaction between L1 and Ankyrins; RHOF GTPase cycle; Formation of the non-canonical BAF (ncBAF) complex; Adherens junctions interactions; Formation of the dystrophin-glycoprotein complex (DGC); VEGFA-VEGFR2 Pathway; RHO GTPases Activate WASPs and WAVEs; Cell-extracellular matrix interactions; EPHB-mediated forward signaling; MAP2K and MAPK activation; Recycling pathway of L1; RHO GTPases activate IQGAPs; Formation of annular gap junctions; B-WICH complex positively regulates rRNA expression; UCH proteinases; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); MAP2K and MAPK activation; Formation of the polybromo-BAF (pBAF) complex; RHO GTPases Activate Formins; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases Activate WASPs and WAVEs; Formation of the dystrophin-glycoprotein complex (DGC); VEGFA-VEGFR2 Pathway; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; DNA Damage Recognition in GG-NER; RHOF GTPase cycle; Cell-extracellular matrix interactions; Adherens junctions interactions; Formation of the non-canonical BAF (ncBAF) complex; Formation of the canonical BAF (cBAF) complex; RHO GTPases activate IQGAPs; Regulation of CDH1 Function; Gap junction degradation; Formation of annular gap junctions; Regulation of actin dynamics for phagocytic cup formation; RHOF GTPase cycle; Clathrin-mediated endocytosis; RHO GTPases Activate Formins; Cell-extracellular matrix interactions; VEGFA-VEGFR2 Pathway; Adherens junctions interactions; RHO GTPases activate IQGAPs; UCH proteinases; EPHB-mediated forward signaling; MAP2K and MAPK activation; RHO GTPases Activate WASPs and WAVEs; Formation of the dystrophin-glycoprotein complex (DGC); Formation of annular gap junctions; Formation of the canonical BAF (cBAF) complex; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of the non-canonical BAF (ncBAF) complex; Regulation of CDH1 Function | 20 | 20 | 20 | 20 | 1.785 | 1.645 | 1.193 | 2.594 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.946568086066385 | 0.994348552930242 | 0.963278515868644 | 0.938282411159324 | 1924782.99006244 | 2098949.09709163 | 1966246.27612296 | 6.9333476629433E7 | 7.92679608662888E7 | 4.66219167617927E7 | 4.31411746831055E7 | 4.48147974340301E7 | 5.69102455002969E7 | 1.21577893646273E8 | 1.207324829685E8 | 8.72162161647777E7 | 5.58171302270344E7 | 3.75040107769213E7 | 6.67519874410893E7 |
| P63260 | Actin, cytoplasmic 2 [OS=Mus musculus] | 217.791 | 70 | 19 | 831 | 2 | 375 | 41.8 | cell organization and biogenesis;stress response;developmental processes;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 11465 | ENSMUSG00000062825 | Actg1 | mmu:11465; P02571; P14104; P63260; P99022 | Myometrial relaxation and contraction pathways; Regulation of actin cytoskeleton; Focal adhesion | Platelet degranulation ; RHO GTPases activate IQGAPs; Adherens junctions interactions; Regulation of CDH1 Function; RHO GTPases Activate Formins; Regulation of actin dynamics for phagocytic cup formation; Interaction between L1 and Ankyrins; MAP2K and MAPK activation; Recycling pathway of L1; Clathrin-mediated endocytosis; Formation of the dystrophin-glycoprotein complex (DGC); EPHB-mediated forward signaling; RHOF GTPase cycle; Formation of annular gap junctions; VEGFA-VEGFR2 Pathway; Cell-extracellular matrix interactions; RHO GTPases Activate WASPs and WAVEs; RHOBTB2 GTPase cycle | 20 | 20 | 20 | 20 | 1 | 1.401 | 0.685 | 1.853 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.85271451854395 | 0.901789796153066 | 0.731487178650893 | 0.819844267712751 | 345218.530665522 | 243712.893345201 | 175067.879334021 | 138179.400499307 | 114235.784978709 | 184680.44906409 | 283414.957020267 | 357431.419092683 | 129167.257177683 | 191405.076269325 | 47386.9835565671 | 139954.449837086 | |||
| P33434 | 72 kDa type IV collagenase [OS=Mus musculus] | 212.03 | 56 | 30 | 889 | 30 | 662 | 74.1 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes | extracellular matrix;plasma membrane;other membranes;cytoskeleton;mitochondrion;nucleus;other cell component | other molecular function | 17390 | ENSMUSG00000031740 | Mmp2 | mmu:17390; P33434 | Lung fibrosis; IL-3 signaling pathway; Matrix metalloproteinases | Collagen degradation; Extra-nuclear estrogen signaling; EPH-ephrin mediated repulsion of cells; Activation of Matrix Metalloproteinases | 6.722 | 1.555 | 9.726 | 3.89 | 1.512 | 3.012 | 2.621 | 1.842 | 0.372996577396536 | 0.964209443670126 | 0.342075680986172 | 0.708142491896103 | 0.993994198406889 | 0.459747209584207 | 0.34519376377552 | 0.809503222445875 | 1.45817945044039E7 | 3.99854546791863E7 | 2.31586213408419E7 | 6.16168347215595E7 | 6.71128653428481E7 | 5.47627512450794E7 | 2.153095933586E7 | 2.04088973517033E7 | 2.1514079157928E7 | 9.59427020238632E7 | 8.49468673692442E7 | 8.11217362792938E7 | 5.65046943814106E7 | 3.5725700482165E7 | 6.85636819548367E7 |
| P19096 | Fatty acid synthase [OS=Mus musculus] | 203.372 | 23 | 48 | 335 | 48 | 2504 | 272.3 | other metabolic processes;stress response;other biological processes | plasma membrane;other membranes;cytosol;ER/Golgi;other cell component | other molecular function | 14104 | ENSMUSG00000025153 | Fasn | B1ATU8; mmu:14104; P19096; Q6PB72; Q8C4Z0; Q9EQR0 | Fatty acid biosynthesis; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-9 fatty acid synthesis; Elongation of (very) long chain fatty acids | Fatty acyl-CoA biosynthesis; Vitamin B5 (pantothenate) metabolism | 3.919 | 2.111 | 2.319 | 4.668 | 1.067 | 1.669 | 0.698 | 2.417 | 0.66189768147619 | 0.847457711018997 | 0.951921622352553 | 0.605074788683686 | 0.87421335771164 | 0.994834213681465 | 0.746782404466558 | 0.990873516209569 | 48161.514825801 | 157425.136778521 | 3018838.26514359 | 3331564.42510829 | 1838171.31939824 | 1125050.80259593 | 1067574.24276956 | 1976727.22395058 | 3354008.01034064 | 3348654.9716265 | 2283763.91979924 | 908323.020723558 | 618361.207888453 | 1151575.74161029 | |
| Cont_Q3SZ57 | Alpha-fetoprotein OS=Bos taurus OX=9913 GN=AFP PE=2 SV=1 | 202.89 | 62 | 30 | 1153 | 29 | 610 | 68.5 | other metabolic processes;developmental processes;other biological processes | non-structural extracellular;other cell component | other molecular function | 506011 | ENSBTAG00000017131 | AFP | bta:506011; Q3SZ57 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 0.89 | 1.253 | 1.171 | 0.883 | 1.251 | 0.689 | 0.666 | 1.305 | 0.540832988168188 | 0.82964085881652 | 0.605387748357992 | 0.553772240900005 | 0.938859506774495 | 0.15729598575093 | 0.699570390946254 | 0.323545662226049 | 4.4629857016799E7 | 4.39639700572647E7 | 2.72178105183923E7 | 3.15168703669999E7 | 4.26075077823651E7 | 3.4328683389093E7 | 4.8541823037709E7 | 4.32960721364381E7 | 4.4115949306695E7 | 4.61564880446121E7 | 4.7548077639711E7 | 3.504265434565E7 | 2.7823391939759E7 | 3.01476017178829E7 | 5.24042356620578E7 | |
| P48678 | Prelamin-A/C [OS=Mus musculus] | 202.607 | 60 | 37 | 529 | 36 | 665 | 74.2 | cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes | other membranes;cytoskeleton;nucleus;other cell component | other molecular function | 16905 | ENSMUSG00000028063 | Lmna | B3RH23; B3RH24; mmu:16905; P11516; P48678; P97859; Q3TIH0; Q3TTS8; Q3U733; Q3U7I5; Q3UCA0; Q3UCJ8; Q3UCU3; Q91WF2; Q9DC21 | Adipogenesis genes; FAS pathway and stress induction of HSP regulation | 20 | 17.997 | 17.767 | 20 | 4.584 | 2.32 | 1.381 | 7.656 | 1.65082956259427E-17 | 0.00670345592293191 | 0.139423967594304 | 1.70336894001643E-17 | 0.236076921565588 | 0.77212820363828 | 0.901149690306505 | 0.00692305873191716 | 56886.7483713492 | 69336.1384695612 | 100943.444664856 | 1.29312831685903E7 | 1.22006597313063E7 | 8045013.512583 | 3337288.2268023 | 3262868.75019265 | 5804803.63611667 | 6.75536277126862E7 | 5.59333072922179E7 | 3.75993669940438E7 | 7422846.33935557 | 4234323.21548912 | 7210898.93259597 | |
| Q02788 | Collagen alpha-2(VI) chain [OS=Mus musculus] | 202.37 | 41 | 36 | 585 | 36 | 1034 | 110.3 | cell adhesion;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component | other molecular function | 12834 | ENSMUSG00000020241 | Col6a2 | mmu:12834; Q02788; Q05505; Q8C972; Q8K229 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | ECM proteoglycans; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation | 10.956 | 20 | 5.246 | 3.501 | 0.458 | 1.362 | 0.325 | 1.848 | 0.175734701097799 | 1.8644578313253E-17 | 0.633123216104285 | 0.767312384697355 | 0.156641881403766 | 0.880899056945259 | 0.0961283818482991 | 0.809503222445875 | 66343.4096791777 | 224638.480326659 | 72730.0086108415 | 5.06665581594054E7 | 6.05623117299827E7 | 4.51585075606234E7 | 4.3575871784427E7 | 3.72580130101725E7 | 4.32608904810994E7 | 2.4375983761655E7 | 2.22548052919965E7 | 1.51565723805374E7 | 1.09937351728106E7 | 7758608.50160191 | 1.64425759910943E7 |
| P97927 | Laminin subunit alpha-4 [OS=Mus musculus] | 199.33 | 30 | 41 | 409 | 41 | 1816 | 201.7 | cell adhesion;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | signal transduction activity or receptor binding | 16775 | ENSMUSG00000019846 | Lama4 | mmu:16775; O88785; P70409; P97927; Q14BF2 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Formation of the dystrophin-glycoprotein complex (DGC); Laminin interactions; MET activates PTK2 signaling | 5.298 | 2.886 | 2.789 | 3.143 | 0.574 | 1.89 | 0.55 | 1.892 | 0.496649188935323 | 0.645007535999596 | 0.952104483873957 | 0.825047045401531 | 0.329011090732691 | 0.929291541980042 | 0.50594120050135 | 0.819844267712751 | 540030.170801593 | 370746.050286439 | 259459.878107817 | 8261193.64464048 | 1.06712284071143E7 | 1.21929154576081E7 | 5309597.35327991 | 4688186.1422195 | 5379156.74886131 | 6459712.32980478 | 5951943.81149588 | 4870147.4483696 | 2541823.46940274 | 2775962.47504545 | 3878847.28463652 |
| P20152 | Vimentin [OS=Mus musculus] | 183.446 | 60 | 29 | 762 | 27 | 466 | 53.7 | cell organization and biogenesis;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component | cytoskeletal activity;nucleic acid binding activity;other molecular function | 22352 | ENSMUSG00000026728 | Vim | mmu:22352; O08704; P20152; Q8CCH1 | Spinal cord injury; Primary focal segmental glomerulosclerosis (FSGS); Alpha 6 beta 4 integrin signaling pathway | Aggrephagy; Striated Muscle Contraction; Caspase-mediated cleavage of cytoskeletal proteins; RHOBTB1 GTPase cycle | 20 | 7.872 | 20 | 13.938 | 2.257 | 5.309 | 1.573 | 6.359 | 1.65082956259427E-17 | 0.0955146622024883 | 1.50457038391225E-17 | 0.137621774180062 | 0.873609880131656 | 0.0297998664849654 | 0.840672080806375 | 0.0332723373064956 | 573727.34417641 | 968981.536762911 | 1794707.43115169 | 4.14069582585024E7 | 3.33312643886138E7 | 2.54656192896882E7 | 6941733.99810384 | 6173483.46835617 | 8980531.63051753 | 8.80704815958352E7 | 8.07026224155391E7 | 5.51524218564722E7 | 1.5029979690535E7 | 6861556.37440952 | 1.68923991921504E7 |
| Q64727 | Vinculin [OS=Mus musculus] | 182.753 | 50 | 45 | 419 | 45 | 1066 | 116.6 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | plasma membrane;other membranes;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 22330 | ENSMUSG00000021823 | Vcl | mmu:22330; Q64727; Q8BP32; Q8BS46; Q922C5; Q922D9 | Primary focal segmental glomerulosclerosis (FSGS); IL-3 signaling pathway; Regulation of actin cytoskeleton; Integrin-mediated cell adhesion; Focal adhesion | Neutrophil degranulation; High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells; Platelet degranulation ; MAP2K and MAPK activation; Smooth Muscle Contraction; Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells; Regulation of CDH1 Function | 9.889 | 5.909 | 12.691 | 5.698 | 1.39 | 2.026 | 1.158 | 2.519 | 0.208404050858596 | 0.190838415616571 | 0.238791978742132 | 0.504745711776551 | 0.964629994744883 | 0.878264980963866 | 0.977491813528386 | 0.958518237573655 | 199164.849916128 | 87100.0128702587 | 92185.322880836 | 5675245.0989599 | 5838625.66584249 | 3008640.49360623 | 1870082.63283096 | 1414114.90526218 | 2577750.73562883 | 7844023.43396073 | 7226639.25078312 | 5204108.91618431 | 2343388.9049214 | 1587883.53032107 | 3146179.30802337 |
| Q8K4G1 | Latent-transforming growth factor beta-binding protein 4 [OS=Mus musculus] | 180.216 | 27 | 29 | 318 | 29 | 1666 | 178.5 | cell-cell signaling;cell organization and biogenesis;transport;signal transduction | non-structural extracellular;extracellular matrix | other molecular function | 108075 | ENSMUSG00000040488 | Ltbp4 | E9QPD9; mmu:108075; Q8K4G0; Q8K4G1 | TGF-beta receptor signaling activates SMADs; Molecules associated with elastic fibres | 7.729 | 4.292 | 20 | 12.27 | 2.67 | 1.52 | 1.837 | 2.119 | 0.308350896322176 | 0.362779483059131 | 1.50457038391225E-17 | 0.170566190602959 | 0.775297640004946 | 0.958956615096849 | 0.703189639676216 | 0.915193515309545 | 20541.0495723262 | 79596.1275426221 | 2657106.34177438 | 3398147.96764637 | 1365787.73467607 | 1578272.63307431 | 1205878.60177515 | 1625778.79640944 | 7998382.13678965 | 8274900.61088866 | 5600614.51816097 | 3209012.09868788 | 1154237.54308251 | 3609675.59166937 | ||
| Q68FD5 | Clathrin heavy chain 1 [OS=Mus musculus] | 180.117 | 32 | 43 | 363 | 43 | 1675 | 191.4 | cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes | plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component | nucleic acid binding activity;other molecular function | 67300 | ENSMUSG00000047126 | Cltc | mmu:67300; Q68FD5 | IL-7 signaling pathway; Kit receptor signaling pathway | MHC class II antigen presentation; Recycling pathway of L1; Cargo recognition for clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis; LDL clearance; Retrograde neurotrophin signalling; Formation of annular gap junctions; Lysosome Vesicle Biogenesis; WNT5A-dependent internalization of FZD4; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation; RHOU GTPase cycle; RHOV GTPase cycle | 6.05 | 5.808 | 20 | 6.768 | 2.931 | 1.275 | 1.251 | 2.935 | 0.4248536990637 | 0.198232028950426 | 1.50457038391225E-17 | 0.413413145615294 | 0.688274955487563 | 0.840666598828607 | 0.946476383814868 | 0.835383236382767 | 19752.350121194 | 9410.067942265 | 2001079.20697008 | 2709198.63758679 | 1592899.41627153 | 1121542.74388673 | 1205380.43272811 | 1952895.490984 | 7620271.96644723 | 6531411.29627789 | 6339405.19264676 | 2211269.42731124 | 1288866.59437226 | 2734753.66820203 | |
| P02469 | Laminin subunit beta-1 [OS=Mus musculus] | 179.863 | 27 | 40 | 429 | 39 | 1786 | 197 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;nucleus;other cell component | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 16777 | ENSMUSG00000002900 | Lamb1 | E9PXZ9; P02469 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Inflammatory response pathway; Alpha 6 beta 4 integrin signaling pathway; Focal adhesion | 9.979 | 4.434 | 6.526 | 2.693 | 0.537 | 1.97 | 0.475 | 2.435 | 0.205801242418232 | 0.341417478664423 | 0.526489846375643 | 0.891178501081124 | 0.269583968882479 | 0.900334730044572 | 0.356773085915651 | 0.98779298590131 | 1.07332672254E7 | 1.09845016908001E7 | 9663847.07936098 | 1.70142446901215E7 | 1.73820787777271E7 | 2.08268192848537E7 | 1.23074043806854E7 | 1.3842748821146E7 | 1.68288599063313E7 | 1.20697658178524E7 | 1.33872705970957E7 | 9031275.37365186 | 2.12878061302996E7 | 2.54341447554609E7 | 1.6513199650281E7 | |
| Q01853 | Transitional endoplasmic reticulum ATPase [OS=Mus musculus] | 179.055 | 52 | 32 | 411 | 32 | 806 | 89.3 | cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;other biological processes | other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;enzyme regulator activity;other molecular function | 269523 | ENSMUSG00000028452 | Vcp | mmu:269523; Q01853; Q3TFH9; Q3TIM2; Q3TXN9; Q6PI18; Q8BSR6; Q8CEG4 | IL-9 signaling pathway | RHOH GTPase cycle; Neutrophil degranulation; Protein methylation; Ovarian tumor domain proteases; Neddylation; ABC-family proteins mediated transport; Translesion Synthesis by POLH; Hedgehog ligand biogenesis; KEAP1-NFE2L2 pathway; HSF1 activation; N-glycan trimming in the ER and Calnexin/Calreticulin cycle; Josephin domain DUBs | 1.775 | 2.885 | 1.782 | 1.945 | 1.345 | 2.036 | 0.893 | 3.238 | 0.915230778358139 | 0.645007535999596 | 0.808626104853287 | 0.953867932777128 | 0.953038161729767 | 0.877818946381645 | 0.901149690306505 | 0.737824045087029 | 462345.280919521 | 876653.458620268 | 526426.850526767 | 1.01571081063743E7 | 9889323.38925712 | 7942233.31155878 | 4702185.44070802 | 4580279.55870278 | 6732778.24078372 | 1.50535993864462E7 | 1.350776734351E7 | 9751498.62422888 | 4128956.06599177 | 3881002.94215154 | 5380991.32313934 |
| Q03350 | Thrombospondin-2 [OS=Mus musculus] | 178.303 | 35 | 30 | 328 | 29 | 1172 | 129.8 | cell adhesion;other biological processes | non-structural extracellular;extracellular matrix;other cell component | other molecular function | 21826 | ENSMUSG00000023885 | Thbs2 | mmu:21826; Q03350; Q8CG21 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Signaling by PDGF; O-glycosylation of TSR domain-containing proteins | 0.722 | 1.325 | 0.917 | 0.852 | 0.905 | 1.968 | 0.612 | 3.033 | 0.425958502904743 | 0.861805134687803 | 0.49027994509233 | 0.535702081245677 | 0.792896707923278 | 0.900334730044572 | 0.620448351319483 | 0.80954066750699 | 2258622.92192986 | 2382783.54746756 | 1148078.18193404 | 1.31796330485542E7 | 1.5104624453426E7 | 5024405.63191042 | 7531099.32555027 | 7013388.1367688 | 7773703.92822199 | 1.11743686938308E7 | 1.16923792648853E7 | 8892616.7561804 | 4798999.04450137 | 2163159.37338424 | 5673668.48605754 |
| Q80YX1 | Tenascin [OS=Mus musculus] | 175.9 | 28 | 43 | 191 | 43 | 2110 | 231.7 | cell adhesion;cell-cell signaling;cell organization and biogenesis;stress response;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | signal transduction activity or receptor binding;other molecular function | 21923 | ENSMUSG00000028364 | Tnc | mmu:21923; Q64706; Q80YX1; Q80YX2 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Integrin cell surface interactions; ECM proteoglycans; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 13.594 | 2.194 | 1.128 | 0.769 | 0.051 | 7.209 | 0.207 | 1.299 | 0.117980756369098 | 0.827773046590747 | 0.560799429150649 | 0.474732236495646 | 1.08858887903907E-8 | 0.00280630917527262 | 0.00972980877962454 | 0.46732263590517 | 11007.0641239407 | 22426.4186578027 | 29153.7668969926 | 1.62969685459921E7 | 1.53776908456905E7 | 4644794.12302626 | 1608421.63729791 | 1232799.46655266 | 1507622.18059477 | 244493.865771831 | 206768.885305398 | 181767.385360463 | 119126.026959952 | 48104.5148614081 | 121500.029653831 |
| Q61147 | Ceruloplasmin [OS=Mus musculus] | 175.43 | 36 | 33 | 380 | 33 | 1061 | 121.1 | cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular | other molecular function | 12870 | ENSMUSG00000003617 | Cp | mmu:12870; Q61147; Q6P5C8 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Iron uptake and transport; Metal ion SLC transporters | 20 | 11.915 | 12.922 | 6.069 | 0.422 | 1.96 | 0.402 | 1.911 | 1.65082956259427E-17 | 0.0286042496128814 | 0.232756100865398 | 0.470567140616547 | 0.114472406028442 | 0.902824569867946 | 0.217345018530886 | 0.830251457557488 | 174325.913751449 | 58856.3090021062 | 115033.849364799 | 9557281.19120236 | 1.04767827169696E7 | 8762702.67228452 | 5461844.00566682 | 4018732.98956624 | 4629071.77649001 | 4355240.25919752 | 3723693.63350954 | 2684226.57769155 | 1556963.66647869 | 1720243.51649846 | 1992732.45731179 | |
| Q3UQ28 | Peroxidasin homolog [OS=Mus musculus] | 173.636 | 35 | 39 | 366 | 39 | 1475 | 165 | cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes | extracellular matrix;ER/Golgi;other cell component | extracellular structural activity;other molecular function | 69675 | ENSMUSG00000020674 | Pxdn | A4FU83; E9QNQ9; mmu:69675; Q3UQ28 | Crosslinking of collagen fibrils | 13.369 | 5.796 | 7.187 | 4.304 | 0.633 | 2.558 | 0.614 | 2.684 | 0.121749369203589 | 0.199060935853007 | 0.481687712882875 | 0.64860195920101 | 0.414844709855988 | 0.680311384167738 | 0.622521206052951 | 0.910753558746772 | 41306.9360165718 | 84058.3874627107 | 31201.070658041 | 9910595.89492489 | 1.28240532958945E7 | 7690537.3381544 | 3188445.14026578 | 3418561.86158515 | 3797799.58981602 | 6834484.53714744 | 5848987.74573488 | 4912888.48741006 | 1858779.55214279 | 743355.386480967 | 2642059.33003837 | |
| Q61316 | Heat shock 70 kDa protein 4 [OS=Mus musculus] | 169.044 | 48 | 31 | 300 | 31 | 841 | 94.1 | protein metabolism;other metabolic processes | other cell component | other molecular function | Hspa4 | Q61316 | Regulation of HSF1-mediated heat shock response | 3.829 | 1.513 | 4.49 | 1.286 | 1.217 | 1.907 | 0.903 | 2.909 | 0.675982462193546 | 0.947627746595709 | 0.704651587991194 | 0.760498481134506 | 0.937908804051419 | 0.922660568001848 | 0.905946265571965 | 0.842404289073844 | 22434.4697799145 | 118934.685179003 | 13120.5332518918 | 3090247.7626811 | 3632683.19217962 | 4934376.07998548 | 1752659.26658268 | 1094548.72984359 | 2299362.24833368 | 6254897.5603188 | 4282912.67963475 | 3832568.37667092 | 1209098.21921722 | 1139246.15986255 | 2002609.64313824 | |||
| Cont_P02533 | Keratin, type I cytoskeletal 14 OS=Homo sapiens OX=9606 GN=KRT14 PE=1 SV=4 | 164.831 | 58 | 26 | 684 | 9 | 472 | 51.5 | cell organization and biogenesis;other biological processes | plasma membrane;cytosol;cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 3861 | ENSG00000186847 | KRT14 | hsa:3861; P02533; Q14715; Q53XY3; Q9BUE3; Q9UBN2; Q9UBN3; Q9UCY4 | Corticotropin-releasing hormone signaling | Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin; Developmental Lineage of Mammary Gland Myoepithelial Cells; Type I hemidesmosome assembly | 1.494 | 1.366 | 1.328 | 2.74 | 0.843 | 1.136 | 1.961 | 0.518 | 0.821333803243143 | 0.880930298968675 | 0.666244110962191 | 0.887279041944908 | 0.735573385767802 | 0.728871118050286 | 0.645534074006669 | 1.76226512549596E-4 | 6033554.14310828 | 6671959.15781397 | 7782964.06135275 | 8837829.92566611 | 1.15627425945257E7 | 9278023.72116937 | 1.41062299354562E7 | 8950994.20838312 | 7841743.81261716 | 1.15454726530467E7 | 7260451.91646668 | 9574113.2223773 | 5.39893889957522E7 | 2.05703168301172E7 | 1.34402077310531E7 |
| P11499 | Heat shock protein HSP 90-beta [OS=Mus musculus] | 164.719 | 50 | 29 | 532 | 19 | 724 | 83.2 | cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component | enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function | 15516 | ENSMUSG00000023944 | Hsp90ab1 | mmu:15516; O89078; P11499; Q3UIQ7 | Focal adhesion: PI3K-Akt-mTOR signaling pathway | Neutrophil degranulation; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of actin dynamics for phagocytic cup formation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Attenuation phase; Estrogen-dependent gene expression; Sema3A PAK dependent Axon repulsion; Aryl hydrocarbon receptor signalling; DDX58/IFIH1-mediated induction of interferon-alpha/beta; HSF1 activation; RHOBTB2 GTPase cycle; The NLRP3 inflammasome | 20 | 20 | 20 | 20 | 1.344 | 3.198 | 1.054 | 3.873 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.952333191127893 | 0.385192173946943 | 0.975071223710592 | 0.476079393565723 | 221410.585638305 | 129165.68527882 | 147525.692220339 | 3.34627647115336E7 | 3.61961534999558E7 | 2.61391308788083E7 | 9541203.16877468 | 9273367.56835581 | 1.36082703259873E7 | 4.57710434253974E7 | 4.37708354854306E7 | 3.73056416942256E7 | 1.17622035416132E7 | 7437513.65495311 | 1.56244060515822E7 |
| Q9JKF1 | Ras GTPase-activating-like protein IQGAP1 [OS=Mus musculus] | 163.926 | 28 | 36 | 250 | 36 | 1657 | 188.6 | cell organization and biogenesis;developmental processes;signal transduction;other biological processes | plasma membrane;other membranes;cytoskeleton;nucleus;other cell component | enzyme regulator activity;other molecular function | 29875 | ENSMUSG00000030536 | Iqgap1 | G3UW45; mmu:29875; Q9JKF1 | G13 signaling pathway; Regulation of actin cytoskeleton | RHO GTPases activate IQGAPs; Neutrophil degranulation; RAC1 GTPase cycle; RAC2 GTPase cycle; RHOA GTPase cycle; MAP2K and MAPK activation; RHOQ GTPase cycle; RHOC GTPase cycle; RHOU GTPase cycle; RHOV GTPase cycle; Nephrin family interactions | 2.389 | 1.188 | 3.792 | 2.098 | 2.451 | 1.85 | 1.692 | 2.634 | 0.930229675308081 | 0.794460986683881 | 0.787568130909409 | 0.991639536226218 | 0.830676695521175 | 0.941920360687835 | 0.777195460870953 | 0.924682711624237 | 49243.316732893 | 68725.418758499 | 969026.209101501 | 1404075.03080168 | 833592.785314498 | 204266.486982725 | 334218.990287697 | 455010.844725875 | 4213732.69874793 | 3933999.53801573 | 3238797.72524118 | 860307.289081776 | 503563.00444482 | 1468565.36197421 | |
| P52480 | Pyruvate kinase PKM [OS=Mus musculus] | 163.393 | 62 | 27 | 442 | 27 | 531 | 57.8 | cell organization and biogenesis;other metabolic processes;other biological processes | cytosol;ER/Golgi;nucleus;other cell component | nucleic acid binding activity;kinase activity;other molecular function | 18746 | ENSMUSG00000032294 | Pkm | mmu:18746; P52480; Q3TBV8; Q3TBW5; Q3TC59; Q3U1X3; Q3U5P6; Q4VC20; Q64484; Q91YI8; Q9CWB1 | Glycolysis and gluconeogenesis; Purine metabolism | Neutrophil degranulation; Pyruvate metabolism; Glycolysis; Regulation of pyruvate metabolism | 20 | 20 | 20 | 20 | 1.91 | 1.562 | 1.218 | 2.517 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.938859506774495 | 0.972868731003358 | 0.958705855138011 | 0.959522188921769 | 312569.127047718 | 79336.1029165598 | 280190.614862653 | 2.13357824001936E7 | 1.96436562290884E7 | 9081648.29120601 | 1.01259485831113E7 | 9467201.29798786 | 1.55257573035923E7 | 3.31547939620584E7 | 3.43565739025104E7 | 2.75852274417617E7 | 1.43901632993649E7 | 7722776.69094361 | 1.86748082798887E7 |
| P63017 | Heat shock cognate 71 kDa protein [OS=Mus musculus] | 161.557 | 53 | 28 | 572 | 23 | 646 | 70.8 | cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component | signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function | 15481 | ENSMUSG00000015656 | Hspa8 | mmu:15481; P08109; P12225; P63017; Q3U6R0; Q3U764; Q3U7D7; Q3U7E2; Q3U9B4; Q3U9G0; Q3UGM0; Q5FWJ6; Q62373; Q62374; Q62375; Q6NZD0 | Mapk signaling pathway; Exercise-induced circadian regulation | Neutrophil degranulation; mRNA Splicing - Major Pathway; Regulation of HSF1-mediated heat shock response; PKR-mediated signaling; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis; Attenuation phase; Lysosome Vesicle Biogenesis; GABA synthesis, release, reuptake and degradation; AUF1 (hnRNP D0) binds and destabilizes mRNA; Protein methylation | 20 | 20 | 20 | 20 | 1.586 | 1.511 | 0.674 | 3.559 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.987939278265184 | 0.953011140807089 | 0.709593139419252 | 0.587315224195015 | 247063.168316828 | 221267.865667273 | 228333.997143376 | 2.34302361722569E7 | 1.91610816116977E7 | 2.44529780700925E7 | 1.52458610795295E7 | 1.21057626921531E7 | 1.98188188374949E7 | 4.35786305197153E7 | 3.523488629513E7 | 2.44125225303247E7 | 1.30838270231471E7 | 9679200.3009757 | 1.32405397257932E7 |
| Q9JHU4 | Cytoplasmic dynein 1 heavy chain 1 [OS=Mus musculus] | 161.009 | 14 | 55 | 258 | 55 | 4644 | 531.7 | cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes | cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 13424 | ENSMUSG00000018707 | Dync1h1 | E9QM71; mmu:13424; Q9JHU4 | MHC class II antigen presentation; Neutrophil degranulation; Separation of Sister Chromatids; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; COPI-mediated anterograde transport; Recruitment of NuMA to mitotic centrosomes; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-independent Golgi-to-ER retrograde traffic; Aggrephagy; Anchoring of the basal body to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; AURKA Activation by TPX2 | 0.975 | 1.246 | 1.606 | 1.856 | 2.687 | 1.626 | 1.854 | 2.534 | 0.591873375996003 | 0.826895204418257 | 0.758743075163871 | 0.936818656936794 | 0.771389136401717 | 0.987352798667733 | 0.695927216301667 | 0.953305976192702 | 224060.75101347 | 288932.991027563 | 370866.333925136 | 1035717.43113769 | 1898525.78207622 | 892363.147243056 | 298543.620628635 | 395801.785314415 | 659710.172961205 | 5741364.17159479 | 5412980.23144293 | 4332188.15134028 | 1541170.38578568 | 1219184.02821873 | 1626625.47525789 | |
| Q99K41 | EMILIN-1 [OS=Mus musculus] | 157.011 | 31 | 21 | 244 | 21 | 1017 | 107.5 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 100952 | ENSMUSG00000029163 | Emilin1 | mmu:100952; Q99K41 | Molecules associated with elastic fibres | 20 | 20 | 20 | 20 | 0.468 | 2.622 | 0.322 | 3.831 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.169879542413978 | 0.64186124184599 | 0.0921665663508908 | 0.491906845171331 | 6287128.66260445 | 6034831.78772075 | 4173278.84836641 | 1744058.35010072 | 1513530.29654839 | 1757558.94039384 | 2698540.13579468 | 2559754.7470142 | 1836473.80243277 | 371444.218276851 | 286714.652107864 | 495091.120602366 | ||||
| Q61879 | Myosin-10 [OS=Mus musculus] | 146 | 19 | 31 | 236 | 20 | 1976 | 228.9 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;nucleic acid binding activity;other molecular function | 77579 | ENSMUSG00000020900 | Myh10 | mmu:77579; Q5SV63; Q61879 | Regulation of actin cytoskeleton | RHO GTPases activate PAKs | 1.209 | 0.791 | 1.357 | 2.489 | 1.52 | 1.681 | 1.232 | 2.649 | 0.705689538076567 | 0.506231596289679 | 0.676239752697828 | 0.933545599871938 | 0.996007724449986 | 0.990096171400123 | 0.953146340313072 | 0.921444667457376 | 132922.802732814 | 81410.1821075416 | 155803.703539863 | 578601.376274227 | 569525.366217458 | 228469.06472958 | 249877.75631 | 195698.454667987 | 352494.602688902 | 1222751.03080206 | 1020719.46631895 | 1025108.65415173 | 659882.564109888 | 489393.525760184 | 539451.948957579 |
| Cont_P00761 | Trypsin OS=Sus scrofa OX=9823 PE=1 SV=1 | 143.502 | 62 | 11 | 3859 | 10 | 231 | 24.4 | protein metabolism;other biological processes | non-structural extracellular | other molecular function | 0.498 | 0.443 | 0.689 | 0.579 | 0.942 | 1.146 | 1.203 | 1.114 | 0.254996071775817 | 0.172153475402034 | 0.357784551188889 | 0.34040294575649 | 0.822223648478518 | 0.740968241512781 | 0.960577895552113 | 0.148582186670595 | 5.17896971017178E9 | 5.13317471139103E9 | 7.27761160813741E9 | 2.70973552724487E9 | 1.73168232498425E9 | 2.0962236592694E9 | 3.08554430734093E9 | 3.85764460784296E9 | 3.06099934235171E9 | 1.42194297351806E9 | 1.8379662886425E9 | 3.81973460995747E9 | 5.23567407489624E9 | 5.3849654871275E9 | 2.81761370832162E9 | ||||||
| P20029 | Endoplasmic reticulum chaperone BiP [OS=Mus musculus] | 142.966 | 48 | 25 | 434 | 23 | 655 | 72.4 | protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component | enzyme regulator activity;translation activity;other molecular function | 14828 | ENSMUSG00000026864 | Hspa5 | mmu:14828; O35642; P20029; Q3UFF2; Q61630 | Mapk signaling pathway | Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Regulation of HSF1-mediated heat shock response | 20 | 20 | 20 | 20 | 2.034 | 1.181 | 1.138 | 2.043 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.916283277860523 | 0.769590657123576 | 0.985707795620743 | 0.888702680095366 | 7850142.93480902 | 7648809.53150357 | 9169945.31743656 | 7535475.80605118 | 5802650.52918468 | 8839942.11003441 | 1.89485602512479E7 | 1.6006905998567E7 | 1.24118184289709E7 | 8533209.24248049 | 7216046.0503345 | 9459779.49149077 | |||
| Cont_P13647 | Keratin, type II cytoskeletal 5 OS=Homo sapiens OX=9606 GN=KRT5 PE=1 SV=3 | 142.395 | 51 | 34 | 500 | 20 | 590 | 62.3 | cell organization and biogenesis;other biological processes | cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;cytoskeletal activity;other molecular function | 3852 | ENSG00000186081 | KRT5 | hsa:3852; P13647; Q6PI71; Q6UBJ0; Q8TA91 | Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin; Developmental Lineage of Mammary Stem Cells; Developmental Lineage of Mammary Gland Myoepithelial Cells; Type I hemidesmosome assembly | 1.412 | 1.296 | 1.45 | 3.637 | 1.063 | 1.124 | 2.854 | 0.442 | 0.786915923361782 | 0.847457711018997 | 0.707170943024881 | 0.746833150482801 | 0.873755746039336 | 0.714156118974909 | 0.2733017775894 | 2.49132633766938E-5 | 5120503.46953844 | 5171426.92187225 | 6553368.21772984 | 9669299.63907403 | 1.1127930529353E7 | 9127716.50969809 | 9513581.76230213 | 7584977.17814252 | 6506980.60696686 | 1.59683716443188E7 | 1.28154121523541E7 | 1.32126695164861E7 | 5.39600661696836E7 | 1.8678004759752E7 | 1.36191738010446E7 | |
| Cont_P08779 | Keratin, type I cytoskeletal 16 OS=Homo sapiens OX=9606 GN=KRT16 PE=1 SV=4 | 140.751 | 54 | 25 | 569 | 12 | 473 | 51.2 | cell organization and biogenesis;stress response;other biological processes | plasma membrane;cytosol;cytoskeleton | cytoskeletal activity | 3868 | ENSG00000186832 | KRT16 | A8K488; hsa:3868; P08779; P30654; Q16402; Q9UBG8 | Vitamin D receptor pathway | Formation of the cornified envelope | 1.858 | 1.769 | 1.616 | 2.725 | 0.945 | 0.933 | 1.398 | 0.544 | 0.941324060398065 | 0.961351301268194 | 0.761460393544015 | 0.887279041944908 | 0.82543231800733 | 0.493923182294169 | 0.895302208460818 | 3.1065941501805E-4 | 1047544.82178002 | 1389728.97312405 | 1389730.63830375 | 1501449.09449526 | 2307427.01338473 | 2939547.44501319 | 7196685.12946156 | 1715910.61220057 | 2812173.28112121 | 4331979.12309994 | 1639569.64130669 | 1737373.70058763 | 9547147.41410007 | 4434008.92515372 | 2223613.02167429 |
| Cont_P02465 | Collagen alpha-2(I) chain OS=Bos taurus OX=9913 GN=COL1A2 PE=1 SV=2 | 139.99 | 18 | 19 | 445 | 3 | 1364 | 129 | non-structural extracellular;extracellular matrix | extracellular structural activity;other molecular function | 282188 | ENSBTAG00000013472 | COL1A2 | A6QP13; bta:282188; O62649; P02465 | Inflammatory response pathway; Focal adhesion | Fibronectin matrix formation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Collagen degradation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; Collagen chain trimerization; GPVI-mediated activation cascade; Platelet Aggregation (Plug Formation); Platelet Adhesion to exposed collagen; GP1b-IX-V activation signalling | 0.802 | 1.357 | 0.812 | 0.776 | 0.839 | 0.601 | 0.572 | 1.046 | 0.483779141493222 | 0.876027096029978 | 0.421836754550416 | 0.488872343346086 | 0.731850662833984 | 0.076245756040016 | 0.549852418071669 | 0.432748651973214 | 80849.8235508145 | 93725.5578519836 | 35755.9745173747 | 170240.553800628 | 153570.468872413 | 167384.810476394 | 78292.6458688874 | 70345.2867467554 | 108688.239366299 | 65032.7123193958 | 48396.6073357386 | 51482.0177898574 | 32903.9376967684 | 51011.1923790395 | 62191.0072542807 | |
| Cont_P12763 | Alpha-2-HS-glycoprotein OS=Bos taurus OX=9913 GN=AHSG PE=1 SV=2 | 132.772 | 50 | 16 | 1191 | 16 | 359 | 38.4 | stress response;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component | enzyme regulator activity | 280988 | AHSG | A6QLF7; bta:280988; P12763 | Neutrophil degranulation; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 0.943 | 1.184 | 1.213 | 0.612 | 1.313 | 0.781 | 0.463 | 2.11 | 0.573667790345329 | 0.793013134473823 | 0.624272910267193 | 0.36488675645736 | 0.946568086066385 | 0.268930374946741 | 0.335956814949331 | 0.913214993335179 | 6.75081036645858E8 | 9.56771805796805E8 | 4.32862555462728E8 | 6.04790296716478E8 | 6.42824998486085E8 | 6.76887564991134E8 | 8.54466282868744E8 | 8.4303805016043E8 | 9.16216503216691E8 | 7.41908408260606E8 | 7.48114705273509E8 | 6.29285280642112E8 | 3.25834950231514E8 | 3.42283489676807E8 | 6.64083343401506E8 | ||
| P07901 | Heat shock protein HSP 90-alpha [OS=Mus musculus] | 132.382 | 43 | 25 | 402 | 16 | 733 | 84.7 | cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component | signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function | 15519 | ENSMUSG00000021270 | Hsp90aa1 | mmu:15519; P07901 | EBV LMP1 signaling; Focal adhesion: PI3K-Akt-mTOR signaling pathway; IL-6 signaling pathway; IL-2 signaling pathway | Regulation of necroptotic cell death; Recruitment of NuMA to mitotic centrosomes; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of actin dynamics for phagocytic cup formation; Neutrophil degranulation; Downregulation of ERBB2 signaling; Anchoring of the basal body to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; AURKA Activation by TPX2; Extra-nuclear estrogen signaling; Attenuation phase; Estrogen-dependent gene expression; Sema3A PAK dependent Axon repulsion; VEGFR2 mediated vascular permeability; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation; DDX58/IFIH1-mediated induction of interferon-alpha/beta; eNOS activation; HSF1 activation; RHOBTB2 GTPase cycle; Drug-mediated inhibition of ERBB2 signaling | 20 | 0.796 | 20 | 9.684 | 1.447 | 2.287 | 1.041 | 3.222 | 1.65082956259427E-17 | 0.508730894200713 | 1.50457038391225E-17 | 0.251664970734015 | 0.974827674952665 | 0.788764875934969 | 0.968364585136618 | 0.745600589176001 | 51071.3130902855 | 169244.190500369 | 193833.457176882 | 3826029.08230807 | 4600695.96516161 | 3479662.10980986 | 1533159.7098775 | 1700635.66665037 | 1768278.53880507 | 6471421.59388824 | 6122550.53993506 | 5450079.38924241 | 1704183.40484156 | 900341.190737514 | 2215799.13247972 |
| Q02819 | Nucleobindin-1 [OS=Mus musculus] | 131.152 | 51 | 21 | 299 | 21 | 459 | 53.4 | signal transduction | non-structural extracellular;other membranes;ER/Golgi | enzyme regulator activity;nucleic acid binding activity;other molecular function | 18220 | ENSMUSG00000030824 | Nucb1 | mmu:18220; Q02819; Q3TU42; Q9CWA1; Q9D8J4; Q9DBL3 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 20 | 20 | 20 | 14.326 | 0.375 | 3.321 | 0.498 | 2.52 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 0.130903496983571 | 0.0679830640731695 | 0.340647566778883 | 0.397987186613988 | 0.958122559708965 | 41072.7931792495 | 20198.6046706008 | 1.70846710933602E7 | 1.97547416617741E7 | 2.08807433533847E7 | 5757191.6972993 | 4828078.95450858 | 5895038.38978249 | 7136546.74332753 | 7387752.88718417 | 5120327.81590923 | 2637872.59598673 | 1130733.36645935 | 3369667.63744922 | ||
| Q91V92 | ATP-citrate synthase [OS=Mus musculus] | 129.973 | 32 | 28 | 237 | 28 | 1091 | 119.7 | other metabolic processes | cytosol | other molecular function | 104112 | ENSMUSG00000020917 | Acly | mmu:104112; Q91V92 | Fatty acid biosynthesis | Neutrophil degranulation; Fatty acyl-CoA biosynthesis | 9.31 | 4.235 | 7.838 | 5.627 | 0.759 | 1.697 | 0.624 | 2.139 | 0.230775890814232 | 0.371468864113786 | 0.437429424171984 | 0.509570119936397 | 0.626059420687734 | 0.98558531112136 | 0.643183834410259 | 0.922580167429744 | 8856.99380706579 | 32765.2400642807 | 40990.0091117865 | 2382723.31982566 | 2481678.51703659 | 2154876.39410613 | 1256305.5375454 | 885993.369046538 | 1688459.92743218 | 2057502.05407172 | 1815562.79058184 | 1460220.9588277 | 594587.914542531 | 534991.757912276 | 802971.776166877 |
| A2ASQ1 | Agrin [OS=Mus musculus] | 128.989 | 18 | 26 | 227 | 26 | 1950 | 207.4 | cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cell component | signal transduction activity or receptor binding;other molecular function | 11603 | ENSMUSG00000041936 | Agrn | A2ASP9; A2ASQ0; A2ASQ1; B2RWU1 | Primary focal segmental glomerulosclerosis (FSGS) | ECM proteoglycans; Retinoid metabolism and transport; Glycosaminoglycan-protein linkage region biosynthesis; HS-GAG biosynthesis; HS-GAG degradation; Formation of the dystrophin-glycoprotein complex (DGC) | 20 | 20 | 20 | 20 | 0.661 | 1.77 | 0.657 | 1.948 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.460727828548759 | 0.972791368602389 | 0.686318824668434 | 0.846971399004193 | 2612028.52511147 | 3116500.52541199 | 3328171.1398056 | 1818519.74579979 | 1551006.46226864 | 1715477.48863677 | 2313945.16119856 | 2044906.61336417 | 1778324.63596447 | 957812.214242183 | 632566.873707257 | 1496109.18442141 | |||
| Q61508 | Extracellular matrix protein 1 [OS=Mus musculus] | 127.379 | 45 | 18 | 358 | 18 | 559 | 62.8 | stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular | signal transduction activity or receptor binding;other molecular function | 13601 | ENSMUSG00000028108 | Ecm1 | mmu:13601; Q3U5Q5; Q61508 | Platelet degranulation | 20 | 20 | 20 | 14.914 | 0.149 | 1.214 | 0.053 | 3.546 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 0.121600547823456 | 2.27890527565265E-4 | 0.795351011232032 | 1.51989274634622E-7 | 0.592370654746194 | 110159.96586707 | 68619.5270607555 | 45654.6843175291 | 5.6443097497098E7 | 7.11751205740166E7 | 5.82782830048746E7 | 5.1935854689884E7 | 4.50204039942893E7 | 5.70225374161979E7 | 1.27540105597053E7 | 1.25514774649527E7 | 8690203.83604475 | 3690111.31703252 | 2192350.97546663 | 4663417.73981907 | |
| Cont_P04259 | Keratin, type II cytoskeletal 6B OS=Homo sapiens OX=9606 GN=KRT6B PE=1 SV=5 | 126.901 | 47 | 30 | 442 | 4 | 564 | 60 | cell organization and biogenesis;other biological processes | cytosol;cytoskeleton | bone, tooth or skin structural activity;cytoskeletal activity | 3854 | ENSG00000185479 | KRT6B | hsa:3854; P04259; P48669 | Formation of the cornified envelope | 1.588 | 2.045 | 1.606 | 3.292 | 1.017 | 0.828 | 1.287 | 0.641 | 0.857251372850113 | 0.868132360832926 | 0.758743075163871 | 0.801271130817871 | 0.854305439376382 | 0.340133476321195 | 0.937453377971347 | 0.00123883404563536 | 267279.779286483 | 355493.362381868 | 274137.281616349 | 326989.588402741 | 585438.697100962 | 617622.938974811 | 2390973.53573307 | 430931.486741926 | 646270.614315847 | 1869779.42318807 | 346417.77494154 | 348508.009299423 | 1653754.7898307 | 1155463.67620058 | 538093.594898596 | |
| P17182 | Alpha-enolase [OS=Mus musculus] | 126.804 | 60 | 19 | 244 | 16 | 434 | 47.1 | other metabolic processes;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;other cell component | nucleic acid binding activity;other molecular function | 13806; 433182 | ENSMUSG00000059040; ENSMUSG00000063524 | Eno1 | mmu:13806; mmu:433182; P17182; Q99KT7; Q9DCY7 | Glycolysis and gluconeogenesis | 20 | 20 | 20 | 20 | 2.837 | 1.204 | 1.518 | 2.329 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.720832939248489 | 0.789540446904924 | 0.858218537342417 | 0.989544231571828 | 31098.019126098 | 70318.9502605952 | 40658.6319347469 | 1.28655809626545E7 | 1.34726279447959E7 | 7101469.5445256 | 9089751.86845938 | 7552189.93174957 | 1.17772011823713E7 | 3.50544676757808E7 | 2.99447661492486E7 | 2.18255690502528E7 | 1.30151947674988E7 | 1.11532480577619E7 | 1.75489228796712E7 | |
| P08113 | Endoplasmin [OS=Mus musculus] | 126.346 | 39 | 26 | 329 | 25 | 802 | 92.4 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cell component | signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function | 22027 | ENSMUSG00000020048 | Hsp90b1 | mmu:22027; P08113; P11427 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Hypoxia-dependent self-renewal of myoblasts | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Scavenging by Class A Receptors; Trafficking and processing of endosomal TLR; Interleukin-4 and Interleukin-13 signaling | 14.282 | 15.982 | 20 | 11.019 | 2.346 | 1.275 | 1.501 | 2.064 | 0.107476768049312 | 0.0104456807471941 | 1.50457038391225E-17 | 0.205304099107124 | 0.854305439376382 | 0.840785133352029 | 0.866766165039268 | 0.896996950298791 | 75656.6139115948 | 52183.5314261123 | 29905.9702816436 | 5932785.14172209 | 5786569.94317903 | 3299962.37110113 | 3817668.17887426 | 3366255.7650389 | 4907428.60350699 | 1.47606948013545E7 | 1.21020755462977E7 | 1.0441016038914E7 | 6464144.86133097 | 3792376.91369813 | 7854793.82920015 |
| P58252 | Elongation factor 2 [OS=Mus musculus] | 126.048 | 37 | 31 | 378 | 30 | 858 | 95.3 | cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;translational apparatus;other cell component | cytoskeletal activity;translation activity;nucleic acid binding activity;other molecular function | 13629 | ENSMUSG00000034994 | Eef2 | mmu:13629; P58252; Q544E4 | Translation factors | Neutrophil degranulation; Protein methylation; Peptide chain elongation; Synthesis of diphthamide-EEF2 | 7.873 | 5.944 | 7.322 | 3.019 | 1.183 | 1.75 | 0.816 | 2.548 | 0.299809054080284 | 0.188334321166369 | 0.471929633209224 | 0.84258396038376 | 0.922179983282929 | 0.97504218639442 | 0.866546043492515 | 0.950878070645738 | 275529.241689771 | 247076.7728808 | 166294.142173825 | 1.22498155967913E7 | 1.26488626480754E7 | 6800245.14611723 | 5717562.35282925 | 5172569.64432748 | 8352282.82529915 | 1.55667000517401E7 | 1.33925688878402E7 | 1.02378508629272E7 | 5184391.52691505 | 2972661.18095993 | 6421886.97759523 |
| Cont_P02538 | Keratin, type II cytoskeletal 6A OS=Homo sapiens OX=9606 GN=KRT6A PE=1 SV=3 | 123.757 | 47 | 30 | 454 | 3 | 564 | 60 | cell organization and biogenesis;stress response;other biological processes | cytosol;cytoskeleton | bone, tooth or skin structural activity;cytoskeletal activity | 3853 | ENSG00000205420 | KRT6A | A4QPC1; hsa:3853; P02538; P48667; Q08AR4; Q6NT67; Q96CL4 | Ectoderm differentiation; Ectoderm differentiation; Pancreatic cancer subtypes | Formation of the cornified envelope | 1.699 | 1.759 | 1.562 | 3.017 | 0.903 | 0.993 | 1.821 | 0.574 | 0.892533464536408 | 0.964633336683333 | 0.745886066139481 | 0.84258396038376 | 0.792564971776066 | 0.574739141583974 | 0.709593139419252 | 5.66461038960431E-4 | 2017098.82314832 | 2171650.09464557 | 2359880.73116726 | 2825309.68904382 | 4320098.03084773 | 4192074.59940388 | 8075888.41129776 | 2685265.07688442 | 3594101.84504227 | 5878699.8667026 | 3215829.01184206 | 2854010.96069105 | 1.30998597349634E7 | 8158147.16608847 | 4198498.19802621 |
| P97298 | Pigment epithelium-derived factor [OS=Mus musculus] | 123.502 | 47 | 16 | 346 | 12 | 417 | 46.2 | cell cycle OR cell proliferation;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | enzyme regulator activity | 20317 | ENSMUSG00000000753 | Serpinf1 | mmu:20317; O70629; O88691; P97298 | 20 | 5.45 | 7.9 | 3.48 | 0.255 | 3.903 | 0.445 | 2.758 | 1.65082956259427E-17 | 0.227296093012204 | 0.434748506750565 | 0.770205086382264 | 0.00901230529014985 | 0.174886032348437 | 0.300753028734261 | 0.891044455497809 | 554016.1710638 | 470705.490372182 | 363015.858993357 | 5.24905837082578E7 | 7.20656975211191E7 | 8.90978835263609E7 | 1.55195541438312E7 | 1.33807646088142E7 | 1.504676823338E7 | 1.63245792137601E7 | 1.5700230598517E7 | 1.5246806329463E7 | 4897006.93274029 | 3869051.7420588 | 8996988.40278734 | ||
| Q70E20 | Sushi, nidogen and EGF-like domain-containing protein 1 [OS=Mus musculus] | 122.942 | 19 | 22 | 287 | 22 | 1403 | 151.5 | cell adhesion | non-structural extracellular;extracellular matrix | other molecular function | 208777 | Sned1 | A6H6I3; mmu:208777; Q70E20; Q810H2; Q8BMD9 | 20 | 20 | 20 | 20 | 2.169 | 2.063 | 1.623 | 2.787 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.889058672589993 | 0.869908412860824 | 0.817293288705596 | 0.880760468933162 | 62940.5062355012 | 25184.2741656831 | 25459.8187779288 | 7879183.70581794 | 8304827.25748066 | 2617617.70526214 | 3110990.0320528 | 3263544.92621848 | 3507274.08693078 | 1.72480350493842E7 | 1.48489121993504E7 | 1.05732378776404E7 | 5373074.41423662 | 2537287.1447922 | 7075122.99473268 | |||
| P13020 | Gelsolin [OS=Mus musculus] | 122.934 | 35 | 22 | 377 | 9 | 780 | 85.9 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 227753 | ENSMUSG00000026879 | Gsn | mmu:227753; P13020; Q3UPB1; Q8R590 | Regulation of actin cytoskeleton | Neutrophil degranulation; Caspase-mediated cleavage of cytoskeletal proteins | 5.883 | 4.057 | 14.912 | 7.221 | 3.038 | 1.646 | 1.821 | 3.103 | 0.440427841758307 | 0.396306424610341 | 0.186266168629733 | 0.379422692457324 | 0.65414435708462 | 0.994546642862744 | 0.709593139419252 | 0.793590033024783 | 1154075.61374729 | 1486973.5078743 | 778278.604931373 | 1.0611315000974E7 | 9755419.92114226 | 9110194.21443976 | 6039243.17546894 | 5549542.61366164 | 7725308.54354706 | 3.63344365935893E7 | 2.77403609084757E7 | 2.33574049877416E7 | 1.03453705657478E7 | 8417203.0170929 | 1.43392014575414E7 |
| Q61398 | Procollagen C-endopeptidase enhancer 1 [OS=Mus musculus] | 120.4 | 40 | 14 | 323 | 14 | 468 | 50.1 | protein metabolism;other biological processes | enzyme regulator activity;other molecular function | 18542 | ENSMUSG00000029718 | Pcolce | mmu:18542; O35113; Q61398 | mRNA processing | Collagen biosynthesis and modifying enzymes; Crosslinking of collagen fibrils | 20 | 20 | 16.934 | 8.868 | 0.439 | 1.204 | 0.32 | 1.719 | 1.65082956259427E-17 | 1.8644578313253E-17 | 0.151224536345852 | 0.288320039261486 | 0.133905327763598 | 0.789540446904924 | 0.0895861566882082 | 0.711902858921665 | 55825.2363051742 | 84655.3590880939 | 113029.200120433 | 3.10244208090572E7 | 2.97623271730106E7 | 2.79757713270171E7 | 2.72578314339105E7 | 2.28908828526637E7 | 2.54654481194513E7 | 1.54882233602667E7 | 1.24902767859117E7 | 9636426.2851997 | 7984547.74798259 | 5125325.32901055 | 9907837.52014591 | |
| P26039 | Talin-1 [OS=Mus musculus] | 118.226 | 15 | 30 | 153 | 30 | 2541 | 269.7 | cell adhesion;cell organization and biogenesis;signal transduction | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;other molecular function | 21894 | ENSMUSG00000028465 | Tln1 | A2AIM8; mmu:21894; P26039; Q8VEF0 | Primary focal segmental glomerulosclerosis (FSGS); Integrin-mediated cell adhesion; Focal adhesion | Platelet degranulation ; MAP2K and MAPK activation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; Smooth Muscle Contraction; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 2.278 | 1.64 | 4.713 | 1.234 | 2.379 | 2.301 | 1.474 | 3.671 | 0.958262397335385 | 0.994542145304377 | 0.680632778351053 | 0.738983404380581 | 0.850917681937748 | 0.783910800136359 | 0.87222702623065 | 0.535066779633529 | 137218.697336797 | 64798.4580467583 | 241653.653741064 | 580168.664793601 | 803244.58151111 | 320387.746187394 | 118081.406885094 | 124079.798936285 | 255551.526824265 | 2877993.84785898 | 2114900.66089323 | 1881659.61273992 | 234819.255172709 | 240671.449108311 | 385063.079961369 |
| Q8BPB5 | EGF-containing fibulin-like extracellular matrix protein 1 [OS=Mus musculus] | 117.738 | 49 | 15 | 220 | 15 | 493 | 54.9 | protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes | extracellular matrix | signal transduction activity or receptor binding;kinase activity;other molecular function | 216616 | ENSMUSG00000020467 | Efemp1 | mmu:216616; Q6Y3N6; Q8BPB5 | 20 | 20 | 20 | 7.265 | 0.542 | 1.608 | 0.36 | 2.306 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 0.376780684027729 | 0.278244203695445 | 0.983440558239231 | 0.145805028390539 | 0.982581944728745 | 15298.8221438323 | 19141.8575027524 | 55545.7753728227 | 7090020.68988726 | 8805500.10345141 | 5126350.07183034 | 4435222.67421531 | 4392813.74676133 | 4496081.41897935 | 4016966.57007158 | 3984703.05528875 | 2817881.79753384 | 1462163.85427198 | 682456.349264741 | 1966499.77195883 | ||
| P09411 | Phosphoglycerate kinase 1 [OS=Mus musculus] | 116.462 | 57 | 18 | 287 | 18 | 417 | 44.5 | protein metabolism;other metabolic processes;stress response;other biological processes | non-structural extracellular;other membranes;cytosol;mitochondrion;other cell component | kinase activity;other molecular function | 18655 | ENSMUSG00000062070 | Pgk1 | mmu:18655; P09411; Q3TPE6; Q3UKV8; Q5XJE7 | Glycolysis and gluconeogenesis | Gluconeogenesis; Glycolysis | 20 | 20 | 20 | 20 | 3.557 | 1.177 | 1.619 | 2.753 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.465126095372736 | 0.766862952867809 | 0.820281310709571 | 0.891044455497809 | 78089.4641074341 | 38741.0917691314 | 23421.0514741904 | 4316274.39280249 | 5023293.68471847 | 1442874.888393 | 2829873.33459098 | 2934698.045784 | 3868274.47312523 | 1.65254946701665E7 | 1.56270051770472E7 | 1.22346365889796E7 | 4530199.20599689 | 2315853.03926933 | 6654180.61411261 |
| P27773 | Protein disulfide-isomerase A3 [OS=Mus musculus] | 115.891 | 55 | 23 | 291 | 23 | 505 | 56.6 | cell adhesion;cell organization and biogenesis;stress response;signal transduction;other biological processes | non-structural extracellular;other membranes;ER/Golgi;other cell component | nucleic acid binding activity;other molecular function | 14827 | ENSMUSG00000027248 | Pdia3 | mmu:14827; P27773; Q3TEI9; Q3TIL2; Q3UZK8; Q8C2F4; Q99LF6 | ER-Phagosome pathway; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Calnexin/calreticulin cycle | 2.463 | 2.512 | 6.915 | 2.818 | 2.389 | 1.306 | 1.442 | 2.187 | 0.9135584231482 | 0.736536116100563 | 0.498293621965442 | 0.874168055361729 | 0.850917681937748 | 0.862063111456553 | 0.881496352314601 | 0.939046770372612 | 206281.038958907 | 253939.7116523 | 128510.108086966 | 6669793.66068216 | 7133803.24141356 | 5637352.69437344 | 5319375.96186612 | 3844376.07822282 | 6321729.00885173 | 1.83298906806341E7 | 1.50101054148645E7 | 1.26051366299531E7 | 6670485.36185494 | 6059857.55300524 | 8984695.03809976 | |
| P10107 | Annexin A1 [OS=Mus musculus] | 115.566 | 64 | 18 | 270 | 18 | 346 | 38.7 | cell organization and biogenesis;stress response;transport;signal transduction;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component | enzyme regulator activity;other molecular function | 16952 | ENSMUSG00000024659 | Anxa1 | mmu:16952; P10107 | Spinal cord injury; Prostaglandin synthesis and regulation | G alpha (q) signalling events; G alpha (i) signalling events; Formyl peptide receptors bind formyl peptides and many other ligands | 20 | 7.59 | 20 | 20 | 1.749 | 3.163 | 2.185 | 2.632 | 1.65082956259427E-17 | 0.105053536950499 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.954328834404239 | 0.401885831342676 | 0.529099828181544 | 0.924766494197286 | 13280.9290610842 | 9160.53166722029 | 4508.77124840677 | 5251880.61554565 | 6740833.31198439 | 6058745.6526555 | 1560362.01883491 | 1521121.84391776 | 1946127.08618424 | 1.11990207127477E7 | 1.0990927807692E7 | 1.0321301103113E7 | 4605609.45936174 | 3223846.7434476 | 4805492.80063037 |
| Cont_Q2KJF1 | Alpha-1B-glycoprotein OS=Bos taurus OX=9913 GN=A1BG PE=1 SV=1 | 115.502 | 48 | 14 | 224 | 14 | 503 | 53.5 | signal transduction | non-structural extracellular;plasma membrane;other membranes | 518955 | A1BG | bta:518955; Q2KJF1 | Platelet degranulation ; Neutrophil degranulation | 1.057 | 0.967 | 1.256 | 0.607 | 1.203 | 1.109 | 0.599 | 2.051 | 0.635218461842139 | 0.655487072215252 | 0.641514600397631 | 0.360991986803736 | 0.932231143665149 | 0.696358249006924 | 0.601376052147163 | 0.891044455497809 | 1.12339445909494E7 | 1.09217008752481E7 | 5999938.28834399 | 7597724.26810103 | 8696294.29830821 | 1.02832125493257E7 | 1.08372253099689E7 | 9914324.88654618 | 8710997.51604168 | 1.11963323092602E7 | 9450705.94975847 | 1.03053408353504E7 | 5283853.74244175 | 5535891.07899516 | 9467766.08082133 | |||
| Cont_Q3MHN5 | Vitamin D-binding protein OS=Bos taurus OX=9913 GN=GC PE=2 SV=1 | 113.599 | 55 | 20 | 319 | 20 | 474 | 53.3 | other metabolic processes;transport | non-structural extracellular;other cell component | transporter activity;cytoskeletal activity;other molecular function | 530076 | GC | bta:530076; Q3MHN5 | 0.903 | 1.209 | 1.108 | 0.763 | 1.298 | 0.671 | 0.583 | 1.405 | 0.549057967251154 | 0.804331105646976 | 0.579435037816218 | 0.479472599858427 | 0.946173787415917 | 0.139718417146003 | 0.570795727084329 | 0.421365656927814 | 1.55879441314789E7 | 1.53074066841615E7 | 7458694.29508707 | 1.04365108192777E7 | 1.20620475306269E7 | 8309099.82300618 | 1.67215053413279E7 | 1.54231806136738E7 | 1.57780518794517E7 | 1.6556516146824E7 | 1.52311500265876E7 | 1.20681229464E7 | 8133055.93664235 | 9478628.98672491 | 1.47438110125204E7 | |||
| P17742 | Peptidyl-prolyl cis-trans isomerase A [OS=Mus musculus] | 113.527 | 60 | 9 | 369 | 9 | 164 | 18 | cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes | non-structural extracellular;cytosol;nucleus;other cell component | signal transduction activity or receptor binding;other molecular function | 268373 | ENSMUSG00000071866 | Ppia | mmu:268373; P17742; Q9CWJ5; Q9R137 | Neutrophil degranulation; Basigin interactions | 14.843 | 7.75 | 20 | 20 | 1.304 | 2.489 | 0.969 | 4.305 | 0.100219677394751 | 0.099382125133403 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.946239447314336 | 0.696358249006924 | 0.937453377971347 | 0.331144967260478 | 1.16891341386391E7 | 754837.409863468 | 4157779.88062054 | 2.9189343463191E7 | 2.94929696895869E7 | 4.96473559496876E7 | 1.04342545713823E7 | 8178713.43858634 | 1.18234267071803E7 | 4.91534751033825E7 | 4.2865019365108E7 | 4.61937263356195E7 | 9682919.1999608 | 7275434.18699702 | 1.51319991253865E7 | |
| Q69ZN7 | Myoferlin [OS=Mus musculus] | 112.647 | 22 | 36 | 227 | 36 | 2048 | 233.2 | cell organization and biogenesis;other metabolic processes;stress response;other biological processes | plasma membrane;other membranes;nucleus | other molecular function | 226101 | ENSMUSG00000048612 | Myof | mmu:226101; Q69ZN7; Q7TMG0; Q80V33; Q8BU64; Q8BU70; Q8BUC1; Q8BVY6; Q8C0D1; Q8R3B4 | 1.293 | 1.754 | 2.079 | 1.82 | 2.532 | 2.029 | 2.027 | 2.284 | 0.73657372909066 | 0.964709887217926 | 0.888974672311279 | 0.930955411749965 | 0.816275429153737 | 0.877818946381645 | 0.609903091678244 | 0.975029032316037 | 86000.3771233404 | 87234.2597428081 | 50456.7230101595 | 780930.944201502 | 985609.680593147 | 968573.73043394 | 296294.389327177 | 289800.794039455 | 380995.072506467 | 3324626.35891918 | 3238695.05806667 | 2634093.62813707 | 1025817.2029614 | 993761.586050851 | 1295229.11918404 | ||
| P26041 | Moesin [OS=Mus musculus] | 112.068 | 47 | 28 | 353 | 19 | 577 | 67.7 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function | 17698 | ENSMUSG00000031207 | Msn | B1AX70; mmu:17698; P26041; Q3UL28; Q8BSN4 | Regulation of actin cytoskeleton | Recycling pathway of L1 | 20 | 9.275 | 20 | 12.906 | 1.135 | 2.551 | 1.147 | 2.527 | 1.65082956259427E-17 | 0.0604972675946614 | 1.50457038391225E-17 | 0.157138696252226 | 0.910750689050232 | 0.682171843898269 | 0.97925982662951 | 0.954396180425051 | 3509434.20481405 | 4360753.56845675 | 2823311.97478394 | 1.57847182977139E7 | 1.58696599538661E7 | 1.95033967654703E7 | 8383545.44173348 | 7552431.53754312 | 1.1473115873696E7 | 2.43209045148915E7 | 1.7265255344344E7 | 1.55060800034236E7 | 7954804.76477835 | 1.24969658442338E7 | 1.31486313258361E7 |
| P05064 | Fructose-bisphosphate aldolase A [OS=Mus musculus] | 112.015 | 66 | 18 | 261 | 18 | 364 | 39.3 | cell organization and biogenesis;other metabolic processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | other molecular function | 11674 | ENSMUSG00000030695 | Aldoa | mmu:11674; P05064 | Glycolysis and gluconeogenesis | Platelet degranulation ; Neutrophil degranulation; Gluconeogenesis; Glycolysis | 14.735 | 18.407 | 20 | 18.77 | 2.091 | 1.259 | 1.091 | 2.228 | 0.101571037453114 | 0.00616383846364181 | 1.50457038391225E-17 | 0.0771819601934254 | 0.907383519445145 | 0.828577692034317 | 0.988377544628277 | 0.953305976192702 | 36553.7681309936 | 18014.3910425567 | 11156.0078725057 | 5538849.24179232 | 5285372.3367409 | 3856062.26656154 | 4263443.39983126 | 3386915.16711964 | 5306808.16889341 | 1.24814165546298E7 | 1.09515793948855E7 | 8528808.13475854 | 4192052.54158905 | 4075248.71161469 | 5289067.55868911 |
| B2RQC6 | Multifunctional protein CAD [OS=Mus musculus] | 111.853 | 18 | 32 | 111 | 32 | 2225 | 243.1 | other metabolic processes;stress response;transport;developmental processes;other biological processes | cytosol;nucleus;other cell component | kinase activity;other molecular function | 69719 | ENSMUSG00000013629 | Cad | B2RQC6; B7ZN27; mmu:69719 | Mechanisms associated with pluripotency | Pyrimidine biosynthesis | 3.69 | 2.77 | 4.876 | 2.316 | 0.581 | 1.776 | 0.743 | 1.7 | 0.69394578118832 | 0.6681512188534 | 0.666244110962191 | 0.963127218853016 | 0.340675523776301 | 0.968897093792999 | 0.798180783050573 | 0.621633895543644 | 55886.6384121637 | 12993.9975368397 | 34438.2113153553 | 1026045.60319635 | 1025412.85494839 | 821784.178770446 | 383358.762218724 | 322831.339780162 | 640190.890369534 | 516093.312619156 | 478923.162373783 | 363366.537093714 | 127462.003140709 | 110686.677299138 | 180829.981634378 |
| Q8BND5 | Sulfhydryl oxidase 1 [OS=Mus musculus] | 111.186 | 35 | 22 | 242 | 22 | 748 | 82.7 | cell organization and biogenesis;other biological processes | non-structural extracellular;other membranes;ER/Golgi | other molecular function | 104009 | ENSMUSG00000033684 | Qsox1 | mmu:104009; Q3TDY9; Q3TE19; Q3TR29; Q3UEL4; Q8BND5; Q8K041; Q9DBL6 | Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Neutrophil degranulation | 20 | 20 | 20 | 12.613 | 0.491 | 2.489 | 0.46 | 2.797 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 0.162753188077458 | 0.203109767081086 | 0.696358249006924 | 0.331332346840573 | 0.877612009404373 | 40119.4404166161 | 10016.9610840251 | 9134645.28263017 | 1.19624109837519E7 | 1.04856878607794E7 | 3750508.26959308 | 3765475.87858746 | 4032369.19900008 | 5503994.64256118 | 5774708.06447186 | 3841814.38132964 | 1498357.95430882 | 1169677.75963505 | 2786812.01379908 |
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| Accession | Description | Sum PEP Score | Coverage [%] | # Peptides | # PSMs | # Unique Peptides | # AAs | MW [kDa] | Biological Process | Cellular Component | Molecular Function | Entrez Gene ID | Ensembl Gene ID | Gene Symbol | Gene ID | WikiPathways | Reactome Pathways | Abundance Ratio Adj. P-Value: (LQ_16h) / FM | Abundance Ratio Adj. P-Value: (LQ_6h) / FM | Abundance Ratio Adj. P-Value: (SQ_16h) / FM | Abundance Ratio Adj. P-Value: (SQ_6h) / FM | Abundance Ratio Adj. P-Value: (SQ_16h) / (LQ_16h) | Abundance Ratio Adj. P-Value: (LQ_16h) / (LQ_6h) | Abundance Ratio Adj. P-Value: (SQ_6h) / (LQ_6h) | Abundance Ratio Adj. P-Value: (SQ_16h) / (SQ_6h) | Abundances (Normalized): F1: Sample, FM | Abundances (Normalized): F2: Sample, FM | Abundances (Normalized): F3: Sample, FM | FM_AVERAGE | Abundances (Normalized): F8: Sample, LQ_16h | Abundances (Normalized): F9: Sample, LQ_16h | Abundances (Normalized): F10: Sample, LQ_16h | LQ16h_AVERAGE | Abundances (Normalized): F4: Sample, LQ_6h | Abundances (Normalized): F5: Sample, LQ_6h | Abundances (Normalized): F6: Sample, LQ_6h | LQ6h_AVERAGE | Abundances (Normalized): F17: Sample, SQ_16h | Abundances (Normalized): F18: Sample, SQ_16h | Abundances (Normalized): F20: Sample, SQ_16h | SQ16h_AVERAGE | Abundances (Normalized): F15: Sample, SQ_6h | Abundances (Normalized): F16: Sample, SQ_6h | Abundances (Normalized): F14: Sample, SQ_6h | SQ6h_AVERAGE |
| P11276 | Fibronectin [OS=Mus musculus] | 867.353 | 58 | 95 | 2246 | 59 | 2477 | 272.4 | cell adhesion;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi | signal transduction activity or receptor binding;enzyme regulator activity;other molecular function | 14268 | ENSMUSG00000026193 | Fn1 | G5E8B8; mmu:14268; P11276; Q61567; Q61568; Q61569; Q64233; Q80UI4 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Inflammatory response pathway; Regulation of actin cytoskeleton; Comprehensive IL-17A signaling; Focal adhesion | ECM proteoglycans; Platelet degranulation ; Cell surface interactions at the vascular wall; Syndecan interactions; MAP2K and MAPK activation; Integrin cell surface interactions; Molecules associated with elastic fibres; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Fibronectin matrix formation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; Degradation of the extracellular matrix; Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells; MET activates PTK2 signaling; GPER1 signaling | 0.0844744457809114 | 0.00584906503121538 | 1.50457038391225E-17 | 0.156115961659409 | 0.974036928885484 | 0.564710097967506 | 0.435823028559966 | 0.896613838854506 | 3.10111960161575E7 | 2.79853612635427E7 | 2.39278028537136E7 | 2.7641453377804603E7 | 2.27076161669542E8 | 2.29530848002383E8 | 1.81481696567249E8 | 2.12696235413058E8 | 2.13523563015262E8 | 1.92386583493888E8 | 2.00792310651879E8 | 2.022341523870097E8 | 3.0604731494329E8 | 2.72875123758133E8 | 2.45952285820886E8 | 2.7495824150743634E8 | 1.00071254189999E8 | 1.59531432686856E8 | 1.1928889459527E8 | 1.2629719382404166E8 |
| P11087 | Collagen alpha-1(I) chain [OS=Mus musculus] | 797.017 | 79 | 75 | 1933 | 35 | 1453 | 137.9 | cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12842 | ENSMUSG00000001506 | Col1a1 | mmu:12842; P11087; Q53WT0; Q60635; Q61367; Q61427; Q63919; Q6PCL3; Q810J9 | Osteoblast signaling; Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Comprehensive IL-17A signaling; Focal adhesion | Cell surface interactions at the vascular wall; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ECM proteoglycans; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; GPVI-mediated activation cascade; GP1b-IX-V activation signalling; Platelet Adhesion to exposed collagen; Platelet Aggregation (Plug Formation); MET activates PTK2 signaling | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 1.58880673198775E-4 | 0.381922652011049 | 0.0629214061377862 | 0.655833157547641 | 703080.609341466 | 1047026.5902454 | 567207.050774397 | 772438.0834537543 | 6.12803341835757E8 | 6.28616080368892E8 | 5.37143706349406E8 | 5.92854376184685E8 | 2.20652487774689E8 | 1.86114398805651E8 | 2.17194307013081E8 | 2.0798706453114033E8 | 9.46570689754052E7 | 9.72166914362706E7 | 6.09758172025116E7 | 8.428319253806247E7 | 4.84358218594371E7 | 7.06441702532683E7 | 6.01286898886734E7 | 5.973622733379293E7 |
| Q01149 | Collagen alpha-2(I) chain [OS=Mus musculus] | 773.662 | 80 | 66 | 1731 | 51 | 1372 | 129.5 | cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12843 | ENSMUSG00000029661 | Col1a2 | mmu:12843; Q01149; Q8CGA5 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Focal adhesion | Crosslinking of collagen fibrils; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; ECM proteoglycans; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; GPVI-mediated activation cascade; GP1b-IX-V activation signalling; Platelet Adhesion to exposed collagen; Platelet Aggregation (Plug Formation); MET activates PTK2 signaling | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.0150838661305169 | 0.862063111456553 | 0.0347692006632991 | 0.926292871155025 | 217896.573253055 | 102775.453905646 | 225868.955510701 | 182180.3275564673 | 3.82374533805921E8 | 3.80614155239716E8 | 2.79801552870279E8 | 3.475967473053053E8 | 1.73556920519588E8 | 1.55763113653521E8 | 1.89931753802048E8 | 1.7308392932505235E8 | 1.03217412397752E8 | 1.04517075360638E8 | 6.33578194684048E7 | 9.036410240893161E7 | 2.65479311979207E7 | 5.19818116295111E7 | 4.96147162399626E7 | 4.271481968913147E7 |
| P08121 | Collagen alpha-1(III) chain [OS=Mus musculus] | 695.631 | 63 | 61 | 1789 | 51 | 1464 | 138.9 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | extracellular matrix;other cell component | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 12825 | ENSMUSG00000026043 | Col3a1 | mmu:12825; P08121; Q61429; Q9CRN7 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Focal adhesion | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ECM proteoglycans; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; MET activates PTK2 signaling | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.00738207855214502 | 0.0413994480640273 | 0.394949139624895 | 0.976852696203657 | 619884.023482232 | 468692.52789102 | 275667.802679115 | 454748.1180174556 | 2.79020579584843E8 | 2.94236692581693E8 | 2.78582579285209E8 | 2.8394661715058166E8 | 6.51340156000414E7 | 5.70632610319163E7 | 6.62894421161806E7 | 6.282890624937943E7 | 7.54516142044654E7 | 7.68700494785543E7 | 4.61499837269909E7 | 6.6157215803336866E7 | 2.39448217703501E7 | 3.64849658219652E7 | 3.06665885804687E7 | 3.0365458724261332E7 |
| Q9QXS1 | Plectin [OS=Mus musculus] | 659.702 | 46 | 182 | 1705 | 180 | 4691 | 533.9 | cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component | cytoskeletal activity;other molecular function | 18810 | ENSMUSG00000022565 | Plec | E9QN87; mmu:18810; Q6S384; Q6S389; Q6S394; Q9CS65; Q9QUT2; Q9QXQ8; Q9QXQ9; Q9QXR0; Q9QXR1; Q9QXR2; Q9QXR3; Q9QXR4; Q9QXR5; Q9QXR6; Q9QXR7; Q9QXR8; Q9QXR9; Q9QXS0; Q9QXS1; Q9QXS2; Q9QXS3 | Alpha 6 beta 4 integrin signaling pathway; EGFR1 signaling pathway | Type I hemidesmosome assembly; Caspase-mediated cleavage of cytoskeletal proteins | 0.481729871164266 | 0.714932595871944 | 0.336550483871782 | 0.572524806937582 | 0.850917681937748 | 0.532399788858771 | 0.702330308974487 | 0.520376293994664 | 307407.817065559 | 282192.990008148 | 340166.735457239 | 309922.514176982 | 1.95783440606639E7 | 1.89230076526173E7 | 1.15266683074569E7 | 1.6676006673579365E7 | 3962115.44279651 | 3474477.32513512 | 6361226.57462356 | 4599273.114185064 | 5.1842207663806E7 | 4.48709077668655E7 | 3.18339270889303E7 | 4.28490141732006E7 | 7604177.6415354 | 1.18325057871337E7 | 1.10137014373925E7 | 1.01501282886872E7 |
| P08122 | Collagen alpha-2(IV) chain [OS=Mus musculus] | 526.992 | 64 | 69 | 1077 | 69 | 1707 | 167.2 | RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix | extracellular structural activity | 12827 | ENSMUSG00000031503 | Col4a2 | mmu:12827; P08122; Q3B7C2; Q3TPV9; Q61375; Q66JS5; Q6RCT6; Q6RCT7; Q6U9X1; Q8BPI9; Q8BPK3; Q91VI3 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Focal adhesion | Laminin interactions; Signaling by PDGF; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions | 0.352816378116182 | 0.64759425713406 | 0.293387877727491 | 0.79866917976589 | 0.979628232635575 | 0.169673447599406 | 0.959159975702413 | 0.483015668880262 | 1499335.01530309 | 1691518.00623855 | 989751.415380184 | 1393534.8123072747 | 5.53234274481973E7 | 5.88619201086468E7 | 3.63990683013196E7 | 5.0194805286054574E7 | 1.35123643610626E7 | 1.30555597235297E7 | 1.53773176128868E7 | 1.3981747232493034E7 | 6.80333035906639E7 | 6.55922447276284E7 | 4.55601360762201E7 | 5.972856146483746E7 | 9511844.25395737 | 2.43703078917008E7 | 1.71661195678148E7 | 1.701609057115766E7 |
| Q3U962 | Collagen alpha-2(V) chain [OS=Mus musculus] | 518.514 | 64 | 57 | 817 | 55 | 1497 | 144.9 | cell organization and biogenesis;developmental processes;other biological processes | extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12832 | ENSMUSG00000026042 | Col5a2 | mmu:12832; Q3TVR2; Q3U962; Q3UHK7; Q3UTT4; Q3V1J6; Q61431; Q7TMS0; Q80VS8 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions | 0.861384746267066 | 0.961254912149485 | 0.730324052254867 | 0.632833892117728 | 0.0769666553885184 | 0.273444295895674 | 0.453486790198347 | 0.973358018692255 | 1.96082795853326E7 | 1.89754303457921E7 | 3.46758133166589E7 | 2.4419841082594533E7 | 4.80275081428664E7 | 4.79991185130461E7 | 4.1747532446715E7 | 4.592471970087584E7 | 1.59204573672189E7 | 1.42782577106181E7 | 1.7061559679881E7 | 1.5753424919239333E7 | 2.09575588581227E7 | 1.96948053072084E7 | 2.25862916575107E7 | 2.1079551940947264E7 | 4881772.8383399 | 8018525.34642114 | 1.85137908486988E7 | 1.0471363011153279E7 |
| Q05793 | Basement membrane-specific heparan sulfate proteoglycan core protein [OS=Mus musculus] | 507.28 | 33 | 84 | 998 | 84 | 3707 | 398 | cell organization and biogenesis;transport;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;ER/Golgi | other molecular function | 15530 | Hspg2 | mmu:15530; Q05793 | 0.332090710292395 | 0.382764581022518 | 0.771134174410141 | 0.553652046981626 | 0.208890689478245 | 0.938381933295379 | 0.285967432697218 | 0.908661395894721 | 136795.508290338 | 206406.403199821 | 169825.859706297 | 171009.25706548532 | 3.70110206606215E7 | 4.34630743166815E7 | 4.28074794537461E7 | 4.109385814368304E7 | 2.41165287907714E7 | 1.91842080304052E7 | 2.07659482289725E7 | 2.1355561683383033E7 | 2.10452863152835E7 | 2.06741361608803E7 | 1.52751209810576E7 | 1.8998181152407136E7 | 5927226.99682882 | 1.0580617159021E7 | 8226367.86740312 | 8244737.341084313 | |||
| Q61554 | Fibrillin-1 [OS=Mus musculus] | 499.202 | 38 | 86 | 1117 | 86 | 2873 | 312.1 | cell adhesion;other metabolic processes;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 14118 | ENSMUSG00000027204 | Fbn1 | A2AQ53; mmu:14118; Q60826; Q61554 | Comprehensive IL-17A signaling | Integrin cell surface interactions; Degradation of the extracellular matrix; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; TGF-beta receptor signaling activates SMADs; Molecules associated with elastic fibres | 0.0596853092747711 | 0.0840496117897429 | 0.378389090130589 | 0.84258396038376 | 0.087482121441914 | 0.862063111456553 | 0.0455630470425967 | 0.77820123247099 | 95282.9912894267 | 109686.773968107 | 40225.7464170883 | 81731.837224874 | 5.82457893686458E7 | 6.62931141873392E7 | 3.19536333419291E7 | 5.216417896597137E7 | 2.33066180631659E7 | 1.9035713753758E7 | 2.29784126659734E7 | 2.17735814942991E7 | 2.39841959808407E7 | 2.29999435869113E7 | 1.54925740961197E7 | 2.082557122129057E7 | 2575605.08863811 | 7345083.32475891 | 5514536.56061601 | 5145074.9913376765 |
| Q8BTM8 | Filamin-A [OS=Mus musculus] | 493.069 | 49 | 91 | 915 | 83 | 2647 | 281 | cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;other molecular function | 192176 | ENSMUSG00000031328 | Flna | B7FAV0; O54934; Q7TQI1; Q8BLK1; Q8BTM8; Q8BTN7; Q8VHX5; Q8VHX8; Q99KQ2 | Mapk signaling pathway; Focal adhesion | Platelet degranulation ; Cell-extracellular matrix interactions; RHO GTPases activate PAKs; GP1b-IX-V activation signalling | 0.0844935092512095 | 0.493514006575528 | 0.170420349138264 | 0.67528135146603 | 0.946239447314336 | 0.864215513767001 | 0.904360680536565 | 0.8468455705593 | 223080.302738683 | 192779.021360071 | 239583.24348992 | 218480.8558628913 | 1.21506602248127E7 | 1.23160583881327E7 | 9719435.76620134 | 1.1395384793048913E7 | 4325195.00464495 | 4176073.86658823 | 6355593.34436329 | 4952287.405198824 | 1.73054238441738E7 | 1.42527501066511E7 | 1.24998953996761E7 | 1.4686023116833666E7 | 2879720.55833739 | 5479053.39146785 | 4531038.34565544 | 4296604.098486893 |
| P02463 | Collagen alpha-1(IV) chain [OS=Mus musculus] | 487.707 | 70 | 68 | 828 | 68 | 1669 | 160.6 | cell organization and biogenesis;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix | extracellular structural activity;other molecular function | 12826 | ENSMUSG00000031502 | Col4a1 | mmu:12826; P02463; Q3UHJ4; Q3UJE7; Q3UQV2; Q53X35; Q6GQS7; Q6PHB5; Q99LQ8 | Spinal cord injury; Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Laminin interactions; Signaling by PDGF; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions | 0.604225174343649 | 0.68008321917751 | 0.284160251285083 | 0.936818656936794 | 0.483508479481234 | 0.167300285011781 | 0.777395712279767 | 0.224623005929948 | 359769.877634713 | 285958.835932462 | 141085.539092917 | 262271.417553364 | 2.00868956379824E7 | 2.17854047157598E7 | 2.25190928918174E7 | 2.1463797748519864E7 | 4657081.16483192 | 4119739.1632835 | 5084724.84322114 | 4620515.057112186 | 3.91843343162395E7 | 3.69562703398771E7 | 2.33283395840594E7 | 3.3156314746725336E7 | 6193195.94075903 | 1.32557370999003E7 | 7286914.931104 | 8911949.32392111 |
| Q60847 | Collagen alpha-1(XII) chain [OS=Mus musculus] | 480.266 | 40 | 95 | 991 | 95 | 3120 | 340 | cell adhesion;developmental processes | other cell component | 12816 | ENSMUSG00000032332 | Col12a1 | mmu:12816; P70322; Q60847 | Assembly of collagen fibrils and other multimeric structures; Collagen chain trimerization; Collagen degradation | 0.0975092237649803 | 1.8644578313253E-17 | 0.344512840834051 | 0.162753188077458 | 0.119424004207039 | 0.101350980560035 | 0.0103905836841461 | 0.266844028199729 | 98450.5264125119 | 58090.3600627237 | 83999.6481680613 | 80180.17821443231 | 3.34408474370425E7 | 3.89438836318894E7 | 1.74727378978336E7 | 2.9952489655588504E7 | 5.74848700994307E7 | 4.49447732262548E7 | 5.27793485517261E7 | 5.1736330625803865E7 | 1.71723257401258E7 | 1.50709974901674E7 | 1.16453026750935E7 | 1.4629541968462234E7 | 6848854.24799245 | 1.38653609093446E7 | 1.0899125462023E7 | 1.0537780206453351E7 | ||
| Q8VDD5 | Myosin-9 [OS=Mus musculus] | 418.364 | 45 | 73 | 827 | 60 | 1960 | 226.2 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;stress response;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;other molecular function | 17886 | ENSMUSG00000022443 | Myh9 | mmu:17886; Q3UHT9; Q3UHU4; Q6KAN6; Q811I2; Q8VDD5 | Primary focal segmental glomerulosclerosis (FSGS) | RHO GTPases activate PAKs; Regulation of actin dynamics for phagocytic cup formation | 0.156498497144098 | 0.0382609387499984 | 0.118876667035285 | 0.15125389278925 | 0.87421335771164 | 0.916542675526027 | 0.91728043005175 | 0.990873516209569 | 107483.529676039 | 153800.887463573 | 39674.4269878413 | 100319.6147091511 | 8783012.74886087 | 9974545.70796386 | 5444477.78467149 | 8067345.413832072 | 4748384.28257292 | 4410554.6604061 | 6370665.87897293 | 5176534.940650649 | 2.10207699044932E7 | 2.09758895852136E7 | 1.72823293907493E7 | 1.9759662960152034E7 | 5517905.75659883 | 9476865.41359831 | 8538625.93793802 | 7844465.70271172 |
| Cont_P02453 | Collagen alpha-1(I) chain OS=Bos taurus OX=9913 GN=COL1A1 PE=1 SV=3 | 414.689 | 43 | 43 | 1208 | 4 | 1463 | 138.9 | cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | 282187 | ENSBTAG00000013103 | COL1A1 | bta:282187; P02453; Q3MHM2 | Inflammatory response pathway; Osteoblast signaling; Focal adhesion | Fibronectin matrix formation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Collagen degradation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; Collagen chain trimerization; GPVI-mediated activation cascade; Platelet Aggregation (Plug Formation); Platelet Adhesion to exposed collagen; GP1b-IX-V activation signalling | 0.800889767710788 | 0.579410556046386 | 0.58548007712969 | 0.839216523231753 | 0.067749585016969 | 0.848119069115724 | 0.108042253370914 | 0.0107964100780951 | 246464.336302772 | 276104.509600215 | 163058.776827813 | 228542.54091026666 | 4343807.62117337 | 4270443.00602544 | 3115927.46864821 | 3910059.36528234 | 3219828.72869598 | 3183952.03023541 | 3383679.40073467 | 3262486.7198886867 | 941743.224351002 | 1075861.66368366 | 756862.710693879 | 924822.5329095138 | 876331.391932507 | 1065336.29340721 | 1364509.18546901 | 1102058.9569362423 |
| Cont_P02769 | Albumin OS=Bos taurus OX=9913 GN=ALB PE=1 SV=4 | 390.555 | 81 | 57 | 7095 | 54 | 607 | 69.2 | stress response;other biological processes | non-structural extracellular;other cell component | nucleic acid binding activity;other molecular function | 280717 | ALB | A5PJX3; bta:280717; O02787; P02769; P04277; Q3SZR2 | 0.520832629933248 | 0.650544967914241 | 0.598172767155558 | 0.497906326712893 | 0.946568086066385 | 0.413798631523592 | 0.846117085258013 | 0.468531677746422 | 3.41035277502904E9 | 3.06531085647989E9 | 1.66716629813739E9 | 2.7142766432154403E9 | 2.0547979326133E9 | 2.37062763488737E9 | 2.78500610382043E9 | 2.4034772237737E9 | 3.09362764542436E9 | 2.55631644026836E9 | 3.07992745656962E9 | 2.9099571807541137E9 | 2.97814649224141E9 | 2.86277256421772E9 | 2.21144220575444E9 | 2.6841204207378564E9 | 2.22855277531216E9 | 3.25384623573346E9 | 1.66052966718895E9 | 2.38097622607819E9 | |||
| P01027 | Complement C3 [OS=Mus musculus] | 388.541 | 53 | 70 | 1148 | 62 | 1663 | 186.4 | cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular;other cell component | signal transduction activity or receptor binding;enzyme regulator activity | 12266 | ENSMUSG00000024164 | C3 | mmu:12266; P01027; Q61370; Q80XP1 | Complement activation, classical pathway; Tyrobp causal network in microglia; Comprehensive IL-17A signaling | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade; Neutrophil degranulation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; G alpha (i) signalling events; Peptide ligand-binding receptors; Alternative complement activation; Activation of C3 and C5 | 0.712660037675161 | 0.729783028721347 | 0.506101547380209 | 0.762068821001752 | 0.939492000987438 | 0.512232143465318 | 0.413470300505934 | 0.991722673088443 | 4040096.73815256 | 3926631.83282415 | 1843021.41157313 | 3269916.660849947 | 4.04154698805798E7 | 4.4896658832648E7 | 4.8335201547635E7 | 4.4549110086954266E7 | 1.80671896153384E7 | 1.47828809765086E7 | 1.7121367805152E7 | 1.6657146132333001E7 | 9.88883606977539E7 | 8.1974398309486E7 | 5.99376709525504E7 | 8.026680998659676E7 | 2.84159228355073E7 | 4.96444404075474E7 | 3.21393016835685E7 | 3.6733221642207734E7 |
| Cont_Q7SIH1 | Alpha-2-macroglobulin OS=Bos taurus OX=9913 GN=A2M PE=1 SV=2 | 370.864 | 53 | 56 | 1089 | 56 | 1510 | 167.5 | non-structural extracellular | enzyme regulator activity;other molecular function | 513856 | ENSBTAG00000018137 | A2M | A8E647; bta:513856; Q7SIH1 | IL-6 signaling pathway | 0.688450665125024 | 0.839052280267302 | 0.731111241255251 | 0.509007335932165 | 0.944154202827561 | 0.540124873725708 | 0.671798309985569 | 0.809503222445875 | 5.71770657169572E7 | 6.35766951637367E7 | 4.19549690627817E7 | 5.423624331449187E7 | 6.46032237401637E7 | 7.37926671048822E7 | 7.2164410166051E7 | 7.018676700369896E7 | 8.06000315293491E7 | 7.23429494984619E7 | 7.40068576999505E7 | 7.564994624258716E7 | 8.7810317845685E7 | 9.50258669209954E7 | 6.46884849507494E7 | 8.250822323914327E7 | 3.96461495018234E7 | 7.63451634810678E7 | 4.10565401116459E7 | 5.23492843648457E7 | ||
| Cont_Q29443 | Serotransferrin OS=Bos taurus OX=9913 GN=TF PE=2 SV=1 | 343.183 | 74 | 48 | 1709 | 46 | 704 | 77.7 | stress response;transport;other biological processes | non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle | other molecular function | 280705 | TF | bta:280705; Q0IIK2; Q29443 | 0.615274986253429 | 0.964709887217926 | 0.600414647182016 | 0.571407162236119 | 0.902231721267411 | 0.105569810421019 | 0.506704636011438 | 0.313748671859839 | 1.71679936327392E8 | 1.91001417946965E8 | 8.41149187199369E7 | 1.48932090998098E8 | 1.24867801818358E8 | 1.55146358811954E8 | 1.88178132242021E8 | 1.5606409762411097E8 | 2.69795837029218E8 | 2.21755859229163E8 | 2.04768415701638E8 | 2.32106703986673E8 | 1.81082969779594E8 | 1.61167381210782E8 | 1.45463022007429E8 | 1.6257112433260167E8 | 1.38609619584445E8 | 1.76572700073531E8 | 9.18433757916485E7 | 1.3567523181654152E8 | |||
| Cont_P07589 | Fibronectin OS=Bos taurus OX=9913 GN=FN1 PE=1 SV=4 | 337.517 | 26 | 47 | 923 | 11 | 2478 | 272 | cell adhesion;cell organization and biogenesis;stress response;developmental processes;other biological processes | non-structural extracellular | signal transduction activity or receptor binding;other molecular function | FN1 | P07589 | 0.714071857030863 | 0.525827426782658 | 0.94971810013306 | 0.802863674292211 | 0.553450172742796 | 0.634088329627404 | 0.35834247597224 | 0.281927255363179 | 142865.797461343 | 209169.389049115 | 146732.075795441 | 166255.75410196633 | 1055759.20189889 | 1052518.92691246 | 748231.640959004 | 952169.9232567847 | 927817.269350189 | 797644.80797335 | 782189.414628216 | 835883.8306505851 | 683356.768802769 | 735882.167003896 | 388557.285212602 | 602598.7403397557 | 334439.098432858 | 506951.879121439 | 606468.327162644 | 482619.7682389803 | ||||
| Q80X90 | Filamin-B [OS=Mus musculus] | 335.882 | 38 | 75 | 608 | 66 | 2602 | 277.7 | cell organization and biogenesis;stress response;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 286940 | ENSMUSG00000025278 | Flnb | E9QNV9; mmu:286940; Q80X90; Q8VHX4; Q8VHX7; Q99KY3 | ISG15 antiviral mechanism | 0.296944306247309 | 0.238365792894698 | 0.254729742039053 | 0.629546282386664 | 0.936411452199724 | 0.897564267605108 | 0.872448101434609 | 0.866446545996913 | 201569.562939035 | 74814.3999578854 | 187488.727848728 | 154624.23024854946 | 5908241.65562211 | 7025090.54357015 | 5213153.27323614 | 6048828.490809467 | 2307098.04671866 | 1545558.91097354 | 3200680.70273347 | 2351112.5534752235 | 8948631.41531232 | 7437294.37435051 | 6391778.7211006 | 7592568.170254476 | 1318356.62479586 | 2409815.97001446 | 1867290.64861647 | 1865154.4144755967 | |
| Cont_P35527 | Keratin, type I cytoskeletal 9 OS=Homo sapiens OX=9606 GN=KRT9 PE=1 SV=3 | 310.424 | 69 | 35 | 915 | 34 | 623 | 62 | cell organization and biogenesis;other biological processes | cytosol;cytoskeleton | cytoskeletal activity | 3857 | ENSG00000171403 | KRT9 | hsa:3857; O00109; P35527; Q0IJ47; Q14665 | Formation of the cornified envelope | 0.836660982916281 | 0.73072258897653 | 0.769556732848094 | 0.964570089320365 | 0.873609880131656 | 0.936669139837906 | 0.516448827835279 | 0.0110179641295352 | 3.00988862408693E7 | 2.22166955848562E7 | 3.53566605858277E7 | 2.9224080803851068E7 | 3.83413938796298E7 | 4.01115354911529E7 | 4.55013850626263E7 | 4.1318104811136335E7 | 3.25056930591839E7 | 3.99576081794461E7 | 2.50556157717982E7 | 3.250630567014273E7 | 4.79768166310243E7 | 2.93517742058567E7 | 7.69722436015544E7 | 5.1433611479478456E7 | 9.27838604678364E7 | 5.6604390657593E7 | 1.31711700890849E8 | 9.369998400542612E7 | |
| Cont_P04264 | Keratin, type II cytoskeletal 1 OS=Homo sapiens OX=9606 GN=KRT1 PE=1 SV=6 | 306.58 | 65 | 45 | 1774 | 36 | 644 | 66 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;other molecular function | 3848 | ENSG00000167768 | KRT1 | B2RA01; hsa:3848; P04264; P85925; P86104; Q14720; Q6GSJ0; Q9H298 | Corticotropin-releasing hormone signaling | Formation of the cornified envelope; Neutrophil degranulation; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.65780924735352 | 0.653826967689551 | 0.631165145316661 | 0.89629386854896 | 0.873609880131656 | 0.770634810212039 | 0.254077056479593 | 5.78940441291519E-5 | 1.31038801811221E8 | 1.49848314576813E8 | 1.81048519054156E8 | 1.5397854514739665E8 | 1.64179912336924E8 | 1.70861004616453E8 | 1.60803236136221E8 | 1.6528138436319932E8 | 1.32005397364365E8 | 1.61355773356369E8 | 1.09071204525108E8 | 1.3414412508194733E8 | 1.84835731298625E8 | 1.38277867637903E8 | 2.0582953187505E8 | 1.7631437693719265E8 | 3.95085049343759E8 | 3.00261678765842E8 | 6.47574942932283E8 | 4.476405570139613E8 |
| P06909 | Complement factor H [OS=Mus musculus] | 292.01 | 49 | 41 | 540 | 41 | 1234 | 139 | cell adhesion;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes | non-structural extracellular;plasma membrane;other membranes;mitochondrion;other cell component | other molecular function | 12628 | ENSMUSG00000026365 | Cfh | mmu:12628; P06909; Q6NZK3 | Regulation of Complement cascade | 0.205200089226065 | 0.0359547312524068 | 1.50457038391225E-17 | 0.329485122608543 | 0.678323397545056 | 0.532399788858771 | 0.750662231008662 | 0.443116920082088 | 45833.2314948132 | 5719.34924483144 | 127074.400703141 | 59542.32714759521 | 9199603.23733176 | 9631512.57691777 | 1.22513356989878E7 | 1.036081717107911E7 | 1.13946236540082E7 | 8948376.12127358 | 1.13575209573925E7 | 1.0566840244224759E7 | 3.40837407850627E7 | 2.84575354110008E7 | 2.55312981422866E7 | 2.9357524779450033E7 | 6857257.31092971 | 1.08034871236965E7 | 7658800.41775084 | 8439848.284125684 | |
| P16546 | Spectrin alpha chain, non-erythrocytic 1 [OS=Mus musculus] | 291.854 | 35 | 74 | 473 | 74 | 2472 | 284.4 | cell organization and biogenesis | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 20740 | ENSMUSG00000057738 | Sptan1 | A3KGU6; A3KGU8; P16546; Q8K380; Q9CT05 | FAS pathway and stress induction of HSP regulation | Neutrophil degranulation; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Interaction between L1 and Ankyrins; COPI-mediated anterograde transport; RHOU GTPase cycle; RHOV GTPase cycle; Caspase-mediated cleavage of cytoskeletal proteins | 0.958962194559628 | 0.786160319109602 | 0.611910908670005 | 0.890289034593217 | 0.929383260195332 | 0.771887919257916 | 0.870511801558508 | 0.852906094467594 | 889916.065158961 | 705414.766907556 | 458549.490375553 | 684626.7741473566 | 4175162.43226982 | 4600176.71769719 | 3155429.78771999 | 3976922.979229001 | 1301153.76848032 | 907755.21332001 | 2072924.21437361 | 1427277.73205798 | 9282178.93349268 | 8610756.12905297 | 6522130.81446154 | 8138355.29233573 | 1477626.07784989 | 2972528.81421804 | 2340149.67970916 | 2263434.85725903 |
| Cont_P13645 | Keratin, type I cytoskeletal 10 OS=Homo sapiens OX=9606 GN=KRT10 PE=1 SV=6 | 286.713 | 62 | 30 | 1322 | 20 | 584 | 58.8 | cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes | plasma membrane;cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;other molecular function | 3858 | ENSG00000186395 | KRT10 | hsa:3858; P13645; Q14664; Q8N175 | Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.600890052902075 | 0.490821286240141 | 0.561934876627864 | 0.941696908693733 | 0.829734761131295 | 0.880940844456856 | 0.246231694954624 | 2.55433624902191E-5 | 8.57039306780817E7 | 1.2308209015436E8 | 1.23973335952419E8 | 1.1091978559495355E8 | 1.09050331614224E8 | 1.30109606828786E8 | 1.02692161896587E8 | 1.13950700113199E8 | 8.73473050095944E7 | 1.23031831133367E8 | 7.19147674496861E7 | 9.409796786421584E7 | 1.29238189237995E8 | 9.43248217623685E7 | 1.03859326412487E8 | 1.0914077913761683E8 | 2.4676744393623E8 | 2.01230291385254E8 | 5.11249836753994E8 | 3.19749190691826E8 | |
| Cont_P35908 | Keratin, type II cytoskeletal 2 epidermal OS=Homo sapiens OX=9606 GN=KRT2 PE=1 SV=2 | 284.975 | 78 | 42 | 1022 | 32 | 639 | 65.4 | cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes | plasma membrane;cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;cytoskeletal activity | 3849 | ENSG00000172867 | KRT2 | hsa:3849; P35908; Q4VAQ2 | Formation of the cornified envelope | 0.499413631103761 | 0.411258958244596 | 0.544106843431104 | 0.933570718645937 | 0.912218866069753 | 0.862063111456553 | 0.309041843038519 | 2.9837536993241E-4 | 2.56957016834685E7 | 6.51011422173888E7 | 5.25056794690703E7 | 4.776750778997586E7 | 3.16465014359267E7 | 4.04662454773149E7 | 3.03458785296059E7 | 3.415287514761583E7 | 2.58420950665494E7 | 4.44581259999837E7 | 1.77732081549674E7 | 2.9357809740500167E7 | 3.88601529372083E7 | 2.41897353529024E7 | 4.54682916268081E7 | 3.617272663897294E7 | 6.73715830359901E7 | 6.38856203067551E7 | 9.79668081708945E7 | 7.640800383787991E7 | |
| Q62059 | Versican core protein [OS=Mus musculus] | 279.715 | 17 | 44 | 1073 | 44 | 3357 | 366.6 | cell adhesion;developmental processes | non-structural extracellular;extracellular matrix;other cell component | other molecular function | Vcan | Q62058; Q62059; Q9CUU0 | ECM proteoglycans; Glycosaminoglycan-protein linkage region biosynthesis; CS/DS degradation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; CS-GAG biosynthesis; DS-GAG biosynthesis | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.854305439376382 | 0.613304974369123 | 0.478009151463064 | 0.783304059803245 | 125473.726574878 | 146060.097046071 | 41031.8651630982 | 104188.56292801573 | 8.44868881898379E7 | 1.01917408783468E8 | 9.76252353450265E7 | 9.467651077277745E7 | 1.00104936351016E8 | 8.17450473009677E7 | 8.92610512588614E7 | 9.037034497028168E7 | 1.04839173391366E8 | 1.06605513712809E8 | 7.38631920533055E7 | 9.510262638582683E7 | 4.44571187520766E7 | 8.14544543672178E7 | 5.09261453344577E7 | 5.89459061512507E7 | |||
| P10493 | Nidogen-1 [OS=Mus musculus] | 275.191 | 43 | 42 | 852 | 42 | 1245 | 136.5 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | other molecular function | 18073 | ENSMUSG00000005397 | Nid1 | mmu:18073; P10493; Q3TKX9; Q8BQI3; Q8C3U8; Q8C9P6 | Laminin interactions; Degradation of the extracellular matrix | 1.65082956259427E-17 | 1.8644578313253E-17 | 0.251140212279038 | 0.461941385639594 | 0.013229256333524 | 0.604382524464811 | 1.0740690550749E-5 | 0.781368126060588 | 439897.722361698 | 266111.080129006 | 261357.080833752 | 322455.2944414853 | 1.30583493944604E8 | 1.41493313555848E8 | 1.08068734992402E8 | 1.2671518083095133E8 | 1.1764867041349E8 | 1.23903817347262E8 | 1.22059347123012E8 | 1.2120394496125467E8 | 3.85653673006923E7 | 3.40794335543811E7 | 2.32700802472122E7 | 3.1971627034095198E7 | 6809358.71273179 | 1.16807558295498E7 | 8950100.03941293 | 9146738.193898173 | |
| O88207 | Collagen alpha-1(V) chain [OS=Mus musculus] | 275.025 | 46 | 52 | 413 | 44 | 1838 | 183.6 | cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes | extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12831 | ENSMUSG00000026837 | Col5a1 | A3KGE3; mmu:12831; O88207; Q3UG94; Q6F6B0 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | ECM proteoglycans; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; MET activates PTK2 signaling | 1.65082956259427E-17 | 1.8644578313253E-17 | 0.268653947705267 | 0.311207075116757 | 0.189625712887896 | 0.848119069115724 | 0.302671730722046 | 0.809503222445875 | 12502.6007438316 | 105962.872602761 | 122701.039249758 | 80388.83753211687 | 8585864.47184676 | 9052435.86465399 | 8047799.6262338 | 8562033.320911517 | 3715509.90739661 | 3183478.03245453 | 3834509.14396516 | 3577832.3612721 | 3548034.64380386 | 3694879.64301103 | 2052789.86607006 | 3098568.0509616495 | 910135.702053452 | 1926767.56075777 | 1322438.93167649 | 1386447.3981625708 |
| P37889 | Fibulin-2 [OS=Mus musculus] | 269.894 | 43 | 37 | 791 | 37 | 1221 | 131.7 | other biological processes | non-structural extracellular | other molecular function | 14115 | ENSMUSG00000064080 | Fbln2 | G5E8B3; mmu:14115; P37889; Q9WUI2 | Molecules associated with elastic fibres | 1.65082956259427E-17 | 0.0640195441309023 | 0.201227492083465 | 0.255240026777032 | 0.453005417011507 | 0.803447472095846 | 0.290132264062119 | 0.809503222445875 | 404936.27628206 | 303410.824570497 | 379728.902265123 | 362692.0010392267 | 7.35240092421165E7 | 8.16716617206073E7 | 8.54486063918813E7 | 8.021475911820169E7 | 7.34239875271171E7 | 6.18846762513378E7 | 6.13955038440774E7 | 6.556805587417743E7 | 5.64407337496573E7 | 5.35180097543675E7 | 3.80873889057723E7 | 4.93487108032657E7 | 2.21115750486307E7 | 3.84218730879294E7 | 2.96696416762988E7 | 3.00676966042863E7 | |
| Q8VHX6 | Filamin-C [OS=Mus musculus] | 249.498 | 31 | 65 | 425 | 56 | 2726 | 290.9 | cell organization and biogenesis;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity | 68794 | ENSMUSG00000068699 | Flnc | B2RY80; B9EKT2; mmu:68794; Q6PAI6; Q8VHX6; Q9JJ38 | Cell-extracellular matrix interactions | 0.562594032195739 | 0.719627996749639 | 0.962331548063155 | 0.57290809187594 | 0.976873891151678 | 0.96786708205164 | 0.933437821008547 | 0.80954066750699 | 362673.376414211 | 453714.7830589 | 401875.758519269 | 406087.97266412666 | 2896613.16388353 | 1997446.07055639 | 1374740.24453431 | 2089599.8263247435 | 898320.393102247 | 899851.262035181 | 1251187.76236098 | 1016453.1391661359 | 4619845.64928082 | 4224920.76413233 | 4533386.9985568 | 4459384.47065665 | 1245417.60281572 | 1275359.84004796 | 889222.28002913 | 1136666.5742976035 | |
| Q04857 | Collagen alpha-1(VI) chain [OS=Mus musculus] | 248.981 | 44 | 33 | 588 | 33 | 1025 | 108.4 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component | other molecular function | 12833 | ENSMUSG00000001119 | Col6a1 | mmu:12833; Q04857 | ECM proteoglycans; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Signaling by PDGF; NCAM1 interactions | 0.2534363617947 | 0.392208211277376 | 0.962331548063155 | 0.971216996811237 | 0.0353343473113635 | 0.97504218639442 | 0.115965329440656 | 0.380888676065133 | 99442.7570537982 | 67304.0023261046 | 63848.8638629308 | 76865.2077476112 | 6.50338448192604E7 | 8.11264443817216E7 | 6.12675161034549E7 | 6.914260176814564E7 | 5.28406132873544E7 | 4.53711044962942E7 | 5.19951028566589E7 | 5.0068940213435836E7 | 2.08305860584001E7 | 2.24322225654869E7 | 1.63957751491443E7 | 1.9886194591010433E7 | 1.00181099527419E7 | 1.94360212112643E7 | 1.39653990737858E7 | 1.4473176745930666E7 | |
| Cont_Q2UVX4 | Complement C3 OS=Bos taurus OX=9913 GN=C3 PE=1 SV=2 | 247.154 | 39 | 55 | 851 | 47 | 1661 | 187.1 | cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular;other cell component | signal transduction activity or receptor binding;enzyme regulator activity | 280677 | ENSBTAG00000017280 | C3 | bta:280677; Q2KIZ4; Q2UVX4 | Complement and coagulation cascades; Complement activation, classical pathway | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Neutrophil degranulation; Peptide ligand-binding receptors; G alpha (i) signalling events; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade; Alternative complement activation; Activation of C3 and C5 | 0.615680953989958 | 0.798729234704005 | 0.573945385766997 | 0.506364847510615 | 0.87421335771164 | 0.291700662163587 | 0.591028379533681 | 0.448532796991499 | 1.66248121121728E7 | 1.69271139045693E7 | 1.05083515570206E7 | 1.4686759191254234E7 | 1.25526666866144E7 | 1.76991579704635E7 | 1.56235874907449E7 | 1.5291804049274266E7 | 1.80944158276855E7 | 1.82336027421103E7 | 1.90370193770683E7 | 1.84550126489547E7 | 1.87583360164926E7 | 1.78001813666833E7 | 1.18248646641963E7 | 1.6127794015790733E7 | 9025681.5960692 | 1.79617171787325E7 | 8899645.14317005 | 1.196234797265725E7 |
| Q62261 | Spectrin beta chain, non-erythrocytic 1 [OS=Mus musculus] | 244.684 | 30 | 61 | 398 | 61 | 2363 | 274.1 | cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 20742 | ENSMUSG00000020315 | Sptbn1 | A2AFU1; mmu:20742; Q3TEM7; Q5SQL8; Q5SQL9; Q62261; Q9QWJ7 | COPI-mediated anterograde transport; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; RHOU GTPase cycle; Interaction between L1 and Ankyrins; RHOV GTPase cycle | 0.69394578118832 | 0.776437620310661 | 0.693719649766064 | 0.831411077141515 | 0.937876734191067 | 0.86315143463057 | 0.664971370235365 | 0.953305976192702 | 373834.445440549 | 533726.562973047 | 569801.107945045 | 492454.03878621367 | 3103526.47805657 | 3181731.16602619 | 2477755.42998989 | 2921004.358024217 | 796281.087102098 | 609431.872132576 | 1356947.15467432 | 920886.7046363313 | 7745784.08821259 | 6610112.71623617 | 4897418.35730506 | 6417771.720584608 | 1743474.26371724 | 2723698.32906552 | 2432765.02616441 | 2299979.2063157237 | |
| Q640N1 | Adipocyte enhancer-binding protein 1 [OS=Mus musculus] | 239.707 | 38 | 34 | 648 | 34 | 1128 | 128.3 | protein metabolism;other biological processes | nucleus;other cell component | nucleic acid binding activity;other molecular function | 11568 | ENSMUSG00000020473 | Aebp1 | mmu:11568; O88442; Q3TVV5; Q3TWA7; Q3TX56; Q3TXB2; Q5NCI9; Q61281; Q640N1 | 0.269326617826563 | 0.0457359864845759 | 0.605387748357992 | 0.631359014803774 | 0.534291750451691 | 0.760992448481534 | 0.145805028390539 | 0.963436677882021 | 3560033.84712119 | 4696620.34449178 | 6275149.80645163 | 4843934.666021533 | 4.59930845855363E7 | 5.69735867783534E7 | 2.04646374454636E7 | 4.1143769603117764E7 | 3.80233154774145E7 | 4.02615711999708E7 | 4.03854487434811E7 | 3.9556778473622136E7 | 3.40966164303398E7 | 3.7490792004469E7 | 2.41166240785119E7 | 3.1901344171106894E7 | 1.40971982755857E7 | 2.68643149803103E7 | 1.4983671743246E7 | 1.8648394999714002E7 | ||
| P57780 | Alpha-actinin-4 [OS=Mus musculus] | 239.42 | 58 | 45 | 483 | 30 | 912 | 104.9 | cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes | cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 60595 | ENSMUSG00000054808 | Actn4 | mmu:60595; P57780 | Primary focal segmental glomerulosclerosis (FSGS) | Platelet degranulation | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 0.19149089837131 | 0.921882153462399 | 0.795351011232032 | 0.968364585136618 | 0.938282411159324 | 5221.79731213346 | 36578.541519335 | 20900.169415734228 | 9107610.67207618 | 1.00453975465233E7 | 1.03378326393571E7 | 9830280.285985528 | 5095419.11923033 | 3409382.50707632 | 5238186.41277381 | 4580996.01302682 | 1.31020350186557E7 | 1.2711162036506E7 | 9162046.18669404 | 1.1658414413951913E7 | 3002316.05426355 | 5816939.08777499 | 4501757.36231035 | 4440337.50144963 | |
| Q7TPR4 | Alpha-actinin-1 [OS=Mus musculus] | 235.529 | 54 | 42 | 511 | 27 | 892 | 103 | cell adhesion;cell organization and biogenesis;other biological processes | plasma membrane;other membranes;cytoskeleton;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function | 109711 | ENSMUSG00000015143 | Actn1 | mmu:109711; Q7TPR4 | Regulation of actin cytoskeleton; Integrin-mediated cell adhesion; Focal adhesion | Platelet degranulation ; RHOF GTPase cycle; RHOBTB2 GTPase cycle; RHOD GTPase cycle; Regulation of cytoskeletal remodeling and cell spreading by IPP complex components | 0.995554138371554 | 0.178726136005694 | 0.819280225722906 | 0.941696908693733 | 0.974207409660283 | 0.744084716394381 | 0.837231569641376 | 0.879972045955715 | 354073.059499792 | 209249.076355465 | 897084.460899514 | 486802.1989182571 | 5526121.35104279 | 6211867.70337129 | 6893436.45630869 | 6210475.170240924 | 2413615.48536692 | 1933168.81934458 | 3229981.90899851 | 2525588.7379033365 | 1.03807818109957E7 | 1.11771340173328E7 | 8282960.99949337 | 9946958.94260729 | 2797115.44078374 | 4939050.64701654 | 3416305.89125481 | 3717490.65968503 |
| P02468 | Laminin subunit gamma-1 [OS=Mus musculus] | 230.882 | 35 | 43 | 454 | 43 | 1607 | 177.2 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | Lamc1 | P02468 | 0.118212047511996 | 0.116315527815218 | 0.459134305737471 | 0.675951294045723 | 0.3041568870489 | 0.877818946381645 | 0.368062651583427 | 0.922276466908065 | 14325.5972836352 | 21883.5466161272 | 18104.5719498812 | 1.5357350900924E7 | 1.57310961044729E7 | 1.74335709018572E7 | 1.61740059690847E7 | 7496762.71625721 | 6775968.90045745 | 7708775.93718172 | 7327169.184632126 | 9245241.37337628 | 9035989.05815721 | 5573559.97495901 | 7951596.802164167 | 2368540.67041914 | 4605215.17131646 | 2765122.91380764 | 3246292.9185144133 | |||||
| Q91ZX7 | Prolow-density lipoprotein receptor-related protein 1 [OS=Mus musculus] | 230.497 | 15 | 57 | 519 | 56 | 4545 | 504.4 | other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;other molecular function | 16971 | Lrp1 | mmu:16971; Q61291; Q91ZX7; Q920Y4 | Statin pathway; Wnt signaling pathway | Scavenging of heme from plasma; Retinoid metabolism and transport | 1.65082956259427E-17 | 0.0181625429641231 | 0.133639440745791 | 0.150830220548111 | 0.687557067265551 | 0.925871264502428 | 0.74148782464906 | 0.901098484497789 | 10237.2255539891 | 51104.3489937616 | 30670.78727387535 | 6875342.47952318 | 6944806.90573824 | 8247481.69257335 | 7355877.025944923 | 4299652.1243919 | 2953538.60705284 | 3392031.85738558 | 3548407.5296101067 | 6405748.2654286 | 5854087.4911046 | 4914685.84613499 | 5724840.5342227295 | 1705219.62694462 | 2981142.11204421 | 2044471.2247951 | 2243610.9879279765 | ||
| Cont_P60712 | Actin, cytoplasmic 1 OS=Bos taurus OX=9913 GN=ACTB PE=1 SV=1 | 225.45 | 70 | 19 | 852 | 2 | 375 | 41.7 | cell organization and biogenesis;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component | enzyme regulator activity;cytoskeletal activity;other molecular function | 100033878; 100135470; 100173832; 101844587; 102139853; 11461; 118833809; 280979; 396526; 403580; 414396; 443052; 450133; 60; 81822 | ENSBTAG00000026199; ENSCAFG00000016020; ENSCAFG00030015381; ENSCAFG00040015695; ENSCPOG00000013467; ENSG00000075624; ENSMAUG00000008763; ENSMUSG00000029580; ENSOARG00040012985; ENSOARG00180022443; ENSOARG00185023855; ENSOARG00215030140; ENSOARG00225009314; ENSPPYG00000017336; ENSPTRG00000018890; ENSRNOG00000034254; ENSSSCG00000007585; ENSSSCG00030003451; ENSSSCG00035038792; ENSSSCG00040049462; ENSSSCG00045027458; ENSSSCG00050065025; ENSSSCG00055012597; ENSSSCG00060019124; ENSSSCG00065037921; ENSSSCG00070011353; ENSSSCG00105030144; ENSSSCG00110026965; ENSSSCG00115013637; ENSSSCG00130033784 | Actb; ACTB | A5D961; A5PKA1; bta:280979; cfa:403580; cpoc:100135470; csab:103246953; ecb:100033878; gga:396526; hsa:60; maua:101844587; mmu:11461; O18840; oas:443052; P02570; P60706; P60707; P60708; P60709; P60710; P60711; P60712; P60713; P70514; P99021; pon:100173832; ptr:450133; Q11209; Q11211; Q3SZD2; Q3TI89; Q3TVP6; Q4L0Y2; Q4R561; Q5R1X3; Q5R582; Q5R6G0; Q64316; Q6QAQ1; Q6ZWM3; Q711N9; Q71FK5; Q75MN2; Q76N69; Q8MIJ0; Q8SPX4; Q95164; Q96B34; Q96HG5; rno:81822; ssc:414396 | FAS pathway and stress induction of HSP regulation; Actin cytoskeleton regulation; Myometrial relaxation and contraction pathways; Focal adhesion; Arrhythmogenic right ventricular cardiomyopathy; Pathogenic Escherichia coli infection; Common pathways underlying drug addiction; Myometrial relaxation and contraction pathways; Focal adhesion; Fas ligand pathway and stress induction of heat shock proteins; Pathogenic Escherichia coli infection; Arrhythmogenic right ventricular cardiomyopathy; Focal adhesion; Myometrial relaxation and contraction pathways; Regulation of actin cytoskeleton; Myometrial relaxation and contraction pathways; Ebola virus infection in host; Acute viral myocarditis; Thermogenesis; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Overlap between signal transduction pathways contributing to LMNA laminopathies; Pleural mesothelioma; Regulation of actin cytoskeleton; Network map of SARS-CoV-2 signaling; Regulation of actin cytoskeleton; Regulation of actin cytoskeleton; Focal adhesion | Formation of the canonical BAF (cBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); Regulation of actin dynamics for phagocytic cup formation; EPH-ephrin mediated repulsion of cells; Formation of annular gap junctions; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; RHO GTPases Activate Formins; RHOF GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; B-WICH complex positively regulates rRNA expression; Regulation of CDH1 Function; Formation of the dystrophin-glycoprotein complex (DGC); Formation of the canonical BAF (cBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); RHO GTPases Activate WASPs and WAVEs; UCH proteinases; DNA Damage Recognition in GG-NER; Formation of the non-canonical BAF (ncBAF) complex; RHO GTPases activate IQGAPs; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Cell-extracellular matrix interactions; MAP2K and MAPK activation; Interaction between L1 and Ankyrins; RHOF GTPase cycle; DNA Damage Recognition in GG-NER; MAP2K and MAPK activation; RHO GTPases Activate Formins; Clathrin-mediated endocytosis; UCH proteinases; RHOF GTPase cycle; DNA Damage Recognition in GG-NER; EPH-ephrin mediated repulsion of cells; VEGFA-VEGFR2 Pathway; Regulation of actin dynamics for phagocytic cup formation; Adherens junctions interactions; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); RHO GTPases Activate WASPs and WAVEs; B-WICH complex positively regulates rRNA expression; Regulation of CDH1 Function; EPHB-mediated forward signaling; Formation of the non-canonical BAF (ncBAF) complex; Formation of the canonical BAF (cBAF) complex; Formation of annular gap junctions; RHO GTPases activate IQGAPs; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; RHO GTPases Activate WASPs and WAVEs; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RHO GTPases activate IQGAPs; RHO GTPases Activate Formins; RHOF GTPase cycle; Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs); B-WICH complex positively regulates rRNA expression; Signaling by BRAF and RAF1 fusions; UCH proteinases; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; VEGFA-VEGFR2 Pathway; Formation of the dystrophin-glycoprotein complex (DGC); Factors involved in megakaryocyte development and platelet production; Regulation of MITF-M-dependent genes involved in pigmentation; Formation of the canonical BAF (cBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); EPH-ephrin mediated repulsion of cells; HATs acetylate histones; Interaction between L1 and Ankyrins; Prefoldin mediated transfer of substrate to CCT/TriC; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Adherens junctions interactions; Regulation of CDH1 Function; Formation of the non-canonical BAF (ncBAF) complex; DNA Damage Recognition in GG-NER; Formation of the polybromo-BAF (pBAF) complex; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Formation of annular gap junctions; Folding of actin by CCT/TriC; Cell-extracellular matrix interactions; MAP2K and MAPK activation; RHO GTPases Activate Formins; Recycling pathway of L1; RHO GTPases activate IQGAPs; Clathrin-mediated endocytosis; Formation of the dystrophin-glycoprotein complex (DGC); EPHB-mediated forward signaling; UCH proteinases; B-WICH complex positively regulates rRNA expression; Adherens junctions interactions; Formation of the non-canonical BAF (ncBAF) complex; Formation of annular gap junctions; Formation of the polybromo-BAF (pBAF) complex; VEGFA-VEGFR2 Pathway; Cell-extracellular matrix interactions; RHO GTPases Activate WASPs and WAVEs; Regulation of CDH1 Function; Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; UCH proteinases; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); Formation of the polybromo-BAF (pBAF) complex; B-WICH complex positively regulates rRNA expression; DNA Damage Recognition in GG-NER; Formation of the canonical BAF (cBAF) complex; RHO GTPases Activate Formins; Regulation of CDH1 Function; Interaction between L1 and Ankyrins; RHOF GTPase cycle; Formation of the non-canonical BAF (ncBAF) complex; Adherens junctions interactions; Formation of the dystrophin-glycoprotein complex (DGC); VEGFA-VEGFR2 Pathway; RHO GTPases Activate WASPs and WAVEs; Cell-extracellular matrix interactions; EPHB-mediated forward signaling; MAP2K and MAPK activation; Recycling pathway of L1; RHO GTPases activate IQGAPs; Formation of annular gap junctions; B-WICH complex positively regulates rRNA expression; UCH proteinases; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); MAP2K and MAPK activation; Formation of the polybromo-BAF (pBAF) complex; RHO GTPases Activate Formins; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases Activate WASPs and WAVEs; Formation of the dystrophin-glycoprotein complex (DGC); VEGFA-VEGFR2 Pathway; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; DNA Damage Recognition in GG-NER; RHOF GTPase cycle; Cell-extracellular matrix interactions; Adherens junctions interactions; Formation of the non-canonical BAF (ncBAF) complex; Formation of the canonical BAF (cBAF) complex; RHO GTPases activate IQGAPs; Regulation of CDH1 Function; Gap junction degradation; Formation of annular gap junctions; Regulation of actin dynamics for phagocytic cup formation; RHOF GTPase cycle; Clathrin-mediated endocytosis; RHO GTPases Activate Formins; Cell-extracellular matrix interactions; VEGFA-VEGFR2 Pathway; Adherens junctions interactions; RHO GTPases activate IQGAPs; UCH proteinases; EPHB-mediated forward signaling; MAP2K and MAPK activation; RHO GTPases Activate WASPs and WAVEs; Formation of the dystrophin-glycoprotein complex (DGC); Formation of annular gap junctions; Formation of the canonical BAF (cBAF) complex; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of the non-canonical BAF (ncBAF) complex; Regulation of CDH1 Function | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.946568086066385 | 0.994348552930242 | 0.963278515868644 | 0.938282411159324 | 1924782.99006244 | 2098949.09709163 | 1966246.27612296 | 1996659.4544256767 | 6.9333476629433E7 | 7.92679608662888E7 | 4.66219167617927E7 | 6.5074451419171505E7 | 4.31411746831055E7 | 4.48147974340301E7 | 5.69102455002969E7 | 4.828873920581084E7 | 1.21577893646273E8 | 1.207324829685E8 | 8.72162161647777E7 | 1.0984219759318356E8 | 3.75040107769213E7 | 6.67519874410893E7 | 5.58171302270344E7 | 5.335770948168167E7 |
| P63260 | Actin, cytoplasmic 2 [OS=Mus musculus] | 217.791 | 70 | 19 | 831 | 2 | 375 | 41.8 | cell organization and biogenesis;stress response;developmental processes;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 11465 | ENSMUSG00000062825 | Actg1 | mmu:11465; P02571; P14104; P63260; P99022 | Myometrial relaxation and contraction pathways; Regulation of actin cytoskeleton; Focal adhesion | Platelet degranulation ; RHO GTPases activate IQGAPs; Adherens junctions interactions; Regulation of CDH1 Function; RHO GTPases Activate Formins; Regulation of actin dynamics for phagocytic cup formation; Interaction between L1 and Ankyrins; MAP2K and MAPK activation; Recycling pathway of L1; Clathrin-mediated endocytosis; Formation of the dystrophin-glycoprotein complex (DGC); EPHB-mediated forward signaling; RHOF GTPase cycle; Formation of annular gap junctions; VEGFA-VEGFR2 Pathway; Cell-extracellular matrix interactions; RHO GTPases Activate WASPs and WAVEs; RHOBTB2 GTPase cycle | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.85271451854395 | 0.901789796153066 | 0.731487178650893 | 0.819844267712751 | 345218.530665522 | 243712.893345201 | 175067.879334021 | 254666.434448248 | 138179.400499307 | 114235.784978709 | 184680.44906409 | 145698.54484736864 | 283414.957020267 | 357431.419092683 | 129167.257177683 | 256671.2110968777 | 47386.9835565671 | 139954.449837086 | 191405.076269325 | 126248.83655432604 | ||||
| P33434 | 72 kDa type IV collagenase [OS=Mus musculus] | 212.03 | 56 | 30 | 889 | 30 | 662 | 74.1 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes | extracellular matrix;plasma membrane;other membranes;cytoskeleton;mitochondrion;nucleus;other cell component | other molecular function | 17390 | ENSMUSG00000031740 | Mmp2 | mmu:17390; P33434 | Lung fibrosis; IL-3 signaling pathway; Matrix metalloproteinases | Collagen degradation; Extra-nuclear estrogen signaling; EPH-ephrin mediated repulsion of cells; Activation of Matrix Metalloproteinases | 0.372996577396536 | 0.964209443670126 | 0.342075680986172 | 0.708142491896103 | 0.993994198406889 | 0.459747209584207 | 0.34519376377552 | 0.809503222445875 | 1.45817945044039E7 | 3.99854546791863E7 | 2.31586213408419E7 | 2.5908623508144036E7 | 6.16168347215595E7 | 6.71128653428481E7 | 5.47627512450794E7 | 6.116415043649567E7 | 2.153095933586E7 | 2.04088973517033E7 | 2.1514079157928E7 | 2.11513119484971E7 | 9.59427020238632E7 | 8.49468673692442E7 | 8.11217362792938E7 | 8.73371018908004E7 | 3.5725700482165E7 | 6.85636819548367E7 | 5.65046943814106E7 | 5.359802560613743E7 |
| P19096 | Fatty acid synthase [OS=Mus musculus] | 203.372 | 23 | 48 | 335 | 48 | 2504 | 272.3 | other metabolic processes;stress response;other biological processes | plasma membrane;other membranes;cytosol;ER/Golgi;other cell component | other molecular function | 14104 | ENSMUSG00000025153 | Fasn | B1ATU8; mmu:14104; P19096; Q6PB72; Q8C4Z0; Q9EQR0 | Fatty acid biosynthesis; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-9 fatty acid synthesis; Elongation of (very) long chain fatty acids | Fatty acyl-CoA biosynthesis; Vitamin B5 (pantothenate) metabolism | 0.66189768147619 | 0.847457711018997 | 0.951921622352553 | 0.605074788683686 | 0.87421335771164 | 0.994834213681465 | 0.746782404466558 | 0.990873516209569 | 48161.514825801 | 157425.136778521 | 102793.32580216101 | 3018838.26514359 | 3331564.42510829 | 1838171.31939824 | 2729524.669883373 | 1125050.80259593 | 1067574.24276956 | 1976727.22395058 | 1389784.0897720233 | 3354008.01034064 | 3348654.9716265 | 2283763.91979924 | 2995475.6339221266 | 618361.207888453 | 1151575.74161029 | 908323.020723558 | 892753.3234074336 | |
| Cont_Q3SZ57 | Alpha-fetoprotein OS=Bos taurus OX=9913 GN=AFP PE=2 SV=1 | 202.89 | 62 | 30 | 1153 | 29 | 610 | 68.5 | other metabolic processes;developmental processes;other biological processes | non-structural extracellular;other cell component | other molecular function | 506011 | ENSBTAG00000017131 | AFP | bta:506011; Q3SZ57 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 0.540832988168188 | 0.82964085881652 | 0.605387748357992 | 0.553772240900005 | 0.938859506774495 | 0.15729598575093 | 0.699570390946254 | 0.323545662226049 | 4.4629857016799E7 | 4.39639700572647E7 | 2.72178105183923E7 | 3.8603879197485335E7 | 3.15168703669999E7 | 4.26075077823651E7 | 3.4328683389093E7 | 3.6151020512819335E7 | 4.8541823037709E7 | 4.32960721364381E7 | 4.4115949306695E7 | 4.5317948160280704E7 | 4.61564880446121E7 | 4.7548077639711E7 | 3.504265434565E7 | 4.2915740009991035E7 | 3.01476017178829E7 | 5.24042356620578E7 | 2.7823391939759E7 | 3.679174310656657E7 | |
| P48678 | Prelamin-A/C [OS=Mus musculus] | 202.607 | 60 | 37 | 529 | 36 | 665 | 74.2 | cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes | other membranes;cytoskeleton;nucleus;other cell component | other molecular function | 16905 | ENSMUSG00000028063 | Lmna | B3RH23; B3RH24; mmu:16905; P11516; P48678; P97859; Q3TIH0; Q3TTS8; Q3U733; Q3U7I5; Q3UCA0; Q3UCJ8; Q3UCU3; Q91WF2; Q9DC21 | Adipogenesis genes; FAS pathway and stress induction of HSP regulation | 1.65082956259427E-17 | 0.00670345592293191 | 0.139423967594304 | 1.70336894001643E-17 | 0.236076921565588 | 0.77212820363828 | 0.901149690306505 | 0.00692305873191716 | 56886.7483713492 | 69336.1384695612 | 100943.444664856 | 75722.11050192213 | 1.29312831685903E7 | 1.22006597313063E7 | 8045013.512583 | 1.1058985470826533E7 | 3337288.2268023 | 3262868.75019265 | 5804803.63611667 | 4134986.871037207 | 6.75536277126862E7 | 5.59333072922179E7 | 3.75993669940438E7 | 5.369543399964929E7 | 4234323.21548912 | 7210898.93259597 | 7422846.33935557 | 6289356.16248022 | |
| Q02788 | Collagen alpha-2(VI) chain [OS=Mus musculus] | 202.37 | 41 | 36 | 585 | 36 | 1034 | 110.3 | cell adhesion;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component | other molecular function | 12834 | ENSMUSG00000020241 | Col6a2 | mmu:12834; Q02788; Q05505; Q8C972; Q8K229 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | ECM proteoglycans; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation | 0.175734701097799 | 1.8644578313253E-17 | 0.633123216104285 | 0.767312384697355 | 0.156641881403766 | 0.880899056945259 | 0.0961283818482991 | 0.809503222445875 | 66343.4096791777 | 224638.480326659 | 72730.0086108415 | 121237.29953889274 | 5.06665581594054E7 | 6.05623117299827E7 | 4.51585075606234E7 | 5.21291258166705E7 | 4.3575871784427E7 | 3.72580130101725E7 | 4.32608904810994E7 | 4.136492509189963E7 | 2.4375983761655E7 | 2.22548052919965E7 | 1.51565723805374E7 | 2.0595787144729633E7 | 7758608.50160191 | 1.64425759910943E7 | 1.09937351728106E7 | 1.173163988850227E7 |
| P97927 | Laminin subunit alpha-4 [OS=Mus musculus] | 199.33 | 30 | 41 | 409 | 41 | 1816 | 201.7 | cell adhesion;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | signal transduction activity or receptor binding | 16775 | ENSMUSG00000019846 | Lama4 | mmu:16775; O88785; P70409; P97927; Q14BF2 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Formation of the dystrophin-glycoprotein complex (DGC); Laminin interactions; MET activates PTK2 signaling | 0.496649188935323 | 0.645007535999596 | 0.952104483873957 | 0.825047045401531 | 0.329011090732691 | 0.929291541980042 | 0.50594120050135 | 0.819844267712751 | 540030.170801593 | 370746.050286439 | 259459.878107817 | 390078.69973194966 | 8261193.64464048 | 1.06712284071143E7 | 1.21929154576081E7 | 1.037511250312096E7 | 5309597.35327991 | 4688186.1422195 | 5379156.74886131 | 5125646.74812024 | 6459712.32980478 | 5951943.81149588 | 4870147.4483696 | 5760601.1965567535 | 2775962.47504545 | 3878847.28463652 | 2541823.46940274 | 3065544.409694903 |
| P20152 | Vimentin [OS=Mus musculus] | 183.446 | 60 | 29 | 762 | 27 | 466 | 53.7 | cell organization and biogenesis;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component | cytoskeletal activity;nucleic acid binding activity;other molecular function | 22352 | ENSMUSG00000026728 | Vim | mmu:22352; O08704; P20152; Q8CCH1 | Spinal cord injury; Primary focal segmental glomerulosclerosis (FSGS); Alpha 6 beta 4 integrin signaling pathway | Aggrephagy; Striated Muscle Contraction; Caspase-mediated cleavage of cytoskeletal proteins; RHOBTB1 GTPase cycle | 1.65082956259427E-17 | 0.0955146622024883 | 1.50457038391225E-17 | 0.137621774180062 | 0.873609880131656 | 0.0297998664849654 | 0.840672080806375 | 0.0332723373064956 | 573727.34417641 | 968981.536762911 | 1794707.43115169 | 1112472.104030337 | 4.14069582585024E7 | 3.33312643886138E7 | 2.54656192896882E7 | 3.3401280645601466E7 | 6941733.99810384 | 6173483.46835617 | 8980531.63051753 | 7365249.698992513 | 8.80704815958352E7 | 8.07026224155391E7 | 5.51524218564722E7 | 7.464184195594883E7 | 6861556.37440952 | 1.68923991921504E7 | 1.5029979690535E7 | 1.292797841903164E7 |
| Q64727 | Vinculin [OS=Mus musculus] | 182.753 | 50 | 45 | 419 | 45 | 1066 | 116.6 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | plasma membrane;other membranes;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 22330 | ENSMUSG00000021823 | Vcl | mmu:22330; Q64727; Q8BP32; Q8BS46; Q922C5; Q922D9 | Primary focal segmental glomerulosclerosis (FSGS); IL-3 signaling pathway; Regulation of actin cytoskeleton; Integrin-mediated cell adhesion; Focal adhesion | Neutrophil degranulation; High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells; Platelet degranulation ; MAP2K and MAPK activation; Smooth Muscle Contraction; Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells; Regulation of CDH1 Function | 0.208404050858596 | 0.190838415616571 | 0.238791978742132 | 0.504745711776551 | 0.964629994744883 | 0.878264980963866 | 0.977491813528386 | 0.958518237573655 | 199164.849916128 | 87100.0128702587 | 92185.322880836 | 126150.06188907423 | 5675245.0989599 | 5838625.66584249 | 3008640.49360623 | 4840837.086136207 | 1870082.63283096 | 1414114.90526218 | 2577750.73562883 | 1953982.7579073233 | 7844023.43396073 | 7226639.25078312 | 5204108.91618431 | 6758257.200309387 | 1587883.53032107 | 3146179.30802337 | 2343388.9049214 | 2359150.5810886133 |
| Q8K4G1 | Latent-transforming growth factor beta-binding protein 4 [OS=Mus musculus] | 180.216 | 27 | 29 | 318 | 29 | 1666 | 178.5 | cell-cell signaling;cell organization and biogenesis;transport;signal transduction | non-structural extracellular;extracellular matrix | other molecular function | 108075 | ENSMUSG00000040488 | Ltbp4 | E9QPD9; mmu:108075; Q8K4G0; Q8K4G1 | TGF-beta receptor signaling activates SMADs; Molecules associated with elastic fibres | 0.308350896322176 | 0.362779483059131 | 1.50457038391225E-17 | 0.170566190602959 | 0.775297640004946 | 0.958956615096849 | 0.703189639676216 | 0.915193515309545 | 20541.0495723262 | 79596.1275426221 | 50068.58855747415 | 2657106.34177438 | 3398147.96764637 | 1365787.73467607 | 2473680.681365607 | 1578272.63307431 | 1205878.60177515 | 1625778.79640944 | 1469976.6770863 | 7998382.13678965 | 8274900.61088866 | 5600614.51816097 | 7291299.088613093 | 1154237.54308251 | 3609675.59166937 | 3209012.09868788 | 2657641.7444799202 | ||
| Q68FD5 | Clathrin heavy chain 1 [OS=Mus musculus] | 180.117 | 32 | 43 | 363 | 43 | 1675 | 191.4 | cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes | plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component | nucleic acid binding activity;other molecular function | 67300 | ENSMUSG00000047126 | Cltc | mmu:67300; Q68FD5 | IL-7 signaling pathway; Kit receptor signaling pathway | MHC class II antigen presentation; Recycling pathway of L1; Cargo recognition for clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis; LDL clearance; Retrograde neurotrophin signalling; Formation of annular gap junctions; Lysosome Vesicle Biogenesis; WNT5A-dependent internalization of FZD4; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation; RHOU GTPase cycle; RHOV GTPase cycle | 0.4248536990637 | 0.198232028950426 | 1.50457038391225E-17 | 0.413413145615294 | 0.688274955487563 | 0.840666598828607 | 0.946476383814868 | 0.835383236382767 | 19752.350121194 | 9410.067942265 | 14581.209031729499 | 2001079.20697008 | 2709198.63758679 | 1592899.41627153 | 2101059.0869428 | 1121542.74388673 | 1205380.43272811 | 1952895.490984 | 1426606.2225329466 | 7620271.96644723 | 6531411.29627789 | 6339405.19264676 | 6830362.818457293 | 1288866.59437226 | 2734753.66820203 | 2211269.42731124 | 2078296.563295177 | |
| P02469 | Laminin subunit beta-1 [OS=Mus musculus] | 179.863 | 27 | 40 | 429 | 39 | 1786 | 197 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;nucleus;other cell component | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 16777 | ENSMUSG00000002900 | Lamb1 | E9PXZ9; P02469 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Inflammatory response pathway; Alpha 6 beta 4 integrin signaling pathway; Focal adhesion | 0.205801242418232 | 0.341417478664423 | 0.526489846375643 | 0.891178501081124 | 0.269583968882479 | 0.900334730044572 | 0.356773085915651 | 0.98779298590131 | 1.07332672254E7 | 1.09845016908001E7 | 9663847.07936098 | 1.0460538665187027E7 | 1.70142446901215E7 | 1.73820787777271E7 | 2.08268192848537E7 | 1.8407714250900764E7 | 1.23074043806854E7 | 1.3842748821146E7 | 1.68288599063313E7 | 1.4326337702720901E7 | 1.20697658178524E7 | 1.33872705970957E7 | 9031275.37365186 | 1.149610392953332E7 | 2.54341447554609E7 | 1.6513199650281E7 | 2.12878061302996E7 | 2.1078383512013834E7 | |
| Q01853 | Transitional endoplasmic reticulum ATPase [OS=Mus musculus] | 179.055 | 52 | 32 | 411 | 32 | 806 | 89.3 | cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;other biological processes | other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;enzyme regulator activity;other molecular function | 269523 | ENSMUSG00000028452 | Vcp | mmu:269523; Q01853; Q3TFH9; Q3TIM2; Q3TXN9; Q6PI18; Q8BSR6; Q8CEG4 | IL-9 signaling pathway | RHOH GTPase cycle; Neutrophil degranulation; Protein methylation; Ovarian tumor domain proteases; Neddylation; ABC-family proteins mediated transport; Translesion Synthesis by POLH; Hedgehog ligand biogenesis; KEAP1-NFE2L2 pathway; HSF1 activation; N-glycan trimming in the ER and Calnexin/Calreticulin cycle; Josephin domain DUBs | 0.915230778358139 | 0.645007535999596 | 0.808626104853287 | 0.953867932777128 | 0.953038161729767 | 0.877818946381645 | 0.901149690306505 | 0.737824045087029 | 462345.280919521 | 876653.458620268 | 526426.850526767 | 621808.5300221853 | 1.01571081063743E7 | 9889323.38925712 | 7942233.31155878 | 9329554.935730066 | 4702185.44070802 | 4580279.55870278 | 6732778.24078372 | 5338414.413398174 | 1.50535993864462E7 | 1.350776734351E7 | 9751498.62422888 | 1.2770955118061693E7 | 3881002.94215154 | 5380991.32313934 | 4128956.06599177 | 4463650.11042755 |
| Q03350 | Thrombospondin-2 [OS=Mus musculus] | 178.303 | 35 | 30 | 328 | 29 | 1172 | 129.8 | cell adhesion;other biological processes | non-structural extracellular;extracellular matrix;other cell component | other molecular function | 21826 | ENSMUSG00000023885 | Thbs2 | mmu:21826; Q03350; Q8CG21 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Signaling by PDGF; O-glycosylation of TSR domain-containing proteins | 0.425958502904743 | 0.861805134687803 | 0.49027994509233 | 0.535702081245677 | 0.792896707923278 | 0.900334730044572 | 0.620448351319483 | 0.80954066750699 | 2258622.92192986 | 2382783.54746756 | 1148078.18193404 | 1929828.2171104867 | 1.31796330485542E7 | 1.5104624453426E7 | 5024405.63191042 | 1.1102887711296873E7 | 7531099.32555027 | 7013388.1367688 | 7773703.92822199 | 7439397.130180354 | 1.11743686938308E7 | 1.16923792648853E7 | 8892616.7561804 | 1.05864549049655E7 | 2163159.37338424 | 5673668.48605754 | 4798999.04450137 | 4211942.301314384 |
| Q80YX1 | Tenascin [OS=Mus musculus] | 175.9 | 28 | 43 | 191 | 43 | 2110 | 231.7 | cell adhesion;cell-cell signaling;cell organization and biogenesis;stress response;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | signal transduction activity or receptor binding;other molecular function | 21923 | ENSMUSG00000028364 | Tnc | mmu:21923; Q64706; Q80YX1; Q80YX2 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Integrin cell surface interactions; ECM proteoglycans; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 0.117980756369098 | 0.827773046590747 | 0.560799429150649 | 0.474732236495646 | 1.08858887903907E-8 | 0.00280630917527262 | 0.00972980877962454 | 0.46732263590517 | 11007.0641239407 | 22426.4186578027 | 29153.7668969926 | 20862.416559578665 | 1.62969685459921E7 | 1.53776908456905E7 | 4644794.12302626 | 1.2106484504902953E7 | 1608421.63729791 | 1232799.46655266 | 1507622.18059477 | 1449614.4281484466 | 244493.865771831 | 206768.885305398 | 181767.385360463 | 211010.04547923067 | 48104.5148614081 | 121500.029653831 | 119126.026959952 | 96243.5238250637 |
| Q61147 | Ceruloplasmin [OS=Mus musculus] | 175.43 | 36 | 33 | 380 | 33 | 1061 | 121.1 | cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular | other molecular function | 12870 | ENSMUSG00000003617 | Cp | mmu:12870; Q61147; Q6P5C8 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Iron uptake and transport; Metal ion SLC transporters | 1.65082956259427E-17 | 0.0286042496128814 | 0.232756100865398 | 0.470567140616547 | 0.114472406028442 | 0.902824569867946 | 0.217345018530886 | 0.830251457557488 | 174325.913751449 | 58856.3090021062 | 115033.849364799 | 116072.0240394514 | 9557281.19120236 | 1.04767827169696E7 | 8762702.67228452 | 9598922.193485493 | 5461844.00566682 | 4018732.98956624 | 4629071.77649001 | 4703216.257241024 | 4355240.25919752 | 3723693.63350954 | 2684226.57769155 | 3587720.1567995367 | 1720243.51649846 | 1992732.45731179 | 1556963.66647869 | 1756646.5467629798 | |
| Q3UQ28 | Peroxidasin homolog [OS=Mus musculus] | 173.636 | 35 | 39 | 366 | 39 | 1475 | 165 | cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes | extracellular matrix;ER/Golgi;other cell component | extracellular structural activity;other molecular function | 69675 | ENSMUSG00000020674 | Pxdn | A4FU83; E9QNQ9; mmu:69675; Q3UQ28 | Crosslinking of collagen fibrils | 0.121749369203589 | 0.199060935853007 | 0.481687712882875 | 0.64860195920101 | 0.414844709855988 | 0.680311384167738 | 0.622521206052951 | 0.910753558746772 | 41306.9360165718 | 84058.3874627107 | 31201.070658041 | 52188.79804577449 | 9910595.89492489 | 1.28240532958945E7 | 7690537.3381544 | 1.0141728842991263E7 | 3188445.14026578 | 3418561.86158515 | 3797799.58981602 | 3468268.863888983 | 6834484.53714744 | 5848987.74573488 | 4912888.48741006 | 5865453.59009746 | 743355.386480967 | 2642059.33003837 | 1858779.55214279 | 1748064.7562207088 | |
| Q61316 | Heat shock 70 kDa protein 4 [OS=Mus musculus] | 169.044 | 48 | 31 | 300 | 31 | 841 | 94.1 | protein metabolism;other metabolic processes | other cell component | other molecular function | Hspa4 | Q61316 | Regulation of HSF1-mediated heat shock response | 0.675982462193546 | 0.947627746595709 | 0.704651587991194 | 0.760498481134506 | 0.937908804051419 | 0.922660568001848 | 0.905946265571965 | 0.842404289073844 | 22434.4697799145 | 118934.685179003 | 13120.5332518918 | 51496.56273693644 | 3090247.7626811 | 3632683.19217962 | 4934376.07998548 | 3885769.0116153997 | 1752659.26658268 | 1094548.72984359 | 2299362.24833368 | 1715523.4149199834 | 6254897.5603188 | 4282912.67963475 | 3832568.37667092 | 4790126.20554149 | 1139246.15986255 | 2002609.64313824 | 1209098.21921722 | 1450318.0074060035 | |||
| Cont_P02533 | Keratin, type I cytoskeletal 14 OS=Homo sapiens OX=9606 GN=KRT14 PE=1 SV=4 | 164.831 | 58 | 26 | 684 | 9 | 472 | 51.5 | cell organization and biogenesis;other biological processes | plasma membrane;cytosol;cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 3861 | ENSG00000186847 | KRT14 | hsa:3861; P02533; Q14715; Q53XY3; Q9BUE3; Q9UBN2; Q9UBN3; Q9UCY4 | Corticotropin-releasing hormone signaling | Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin; Developmental Lineage of Mammary Gland Myoepithelial Cells; Type I hemidesmosome assembly | 0.821333803243143 | 0.880930298968675 | 0.666244110962191 | 0.887279041944908 | 0.735573385767802 | 0.728871118050286 | 0.645534074006669 | 1.76226512549596E-4 | 6033554.14310828 | 6671959.15781397 | 7782964.06135275 | 6829492.454091667 | 8837829.92566611 | 1.15627425945257E7 | 9278023.72116937 | 9892865.41378706 | 1.41062299354562E7 | 8950994.20838312 | 7841743.81261716 | 1.0299655985485494E7 | 1.15454726530467E7 | 7260451.91646668 | 9574113.2223773 | 9460012.597296894 | 2.05703168301172E7 | 1.34402077310531E7 | 5.39893889957522E7 | 2.9333304518974166E7 |
| P11499 | Heat shock protein HSP 90-beta [OS=Mus musculus] | 164.719 | 50 | 29 | 532 | 19 | 724 | 83.2 | cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component | enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function | 15516 | ENSMUSG00000023944 | Hsp90ab1 | mmu:15516; O89078; P11499; Q3UIQ7 | Focal adhesion: PI3K-Akt-mTOR signaling pathway | Neutrophil degranulation; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of actin dynamics for phagocytic cup formation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Attenuation phase; Estrogen-dependent gene expression; Sema3A PAK dependent Axon repulsion; Aryl hydrocarbon receptor signalling; DDX58/IFIH1-mediated induction of interferon-alpha/beta; HSF1 activation; RHOBTB2 GTPase cycle; The NLRP3 inflammasome | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.952333191127893 | 0.385192173946943 | 0.975071223710592 | 0.476079393565723 | 221410.585638305 | 129165.68527882 | 147525.692220339 | 166033.98771248801 | 3.34627647115336E7 | 3.61961534999558E7 | 2.61391308788083E7 | 3.193268303009924E7 | 9541203.16877468 | 9273367.56835581 | 1.36082703259873E7 | 1.0807613687705928E7 | 4.57710434253974E7 | 4.37708354854306E7 | 3.73056416942256E7 | 4.22825068683512E7 | 7437513.65495311 | 1.56244060515822E7 | 1.17622035416132E7 | 1.1608041082716169E7 |
| Q9JKF1 | Ras GTPase-activating-like protein IQGAP1 [OS=Mus musculus] | 163.926 | 28 | 36 | 250 | 36 | 1657 | 188.6 | cell organization and biogenesis;developmental processes;signal transduction;other biological processes | plasma membrane;other membranes;cytoskeleton;nucleus;other cell component | enzyme regulator activity;other molecular function | 29875 | ENSMUSG00000030536 | Iqgap1 | G3UW45; mmu:29875; Q9JKF1 | G13 signaling pathway; Regulation of actin cytoskeleton | RHO GTPases activate IQGAPs; Neutrophil degranulation; RAC1 GTPase cycle; RAC2 GTPase cycle; RHOA GTPase cycle; MAP2K and MAPK activation; RHOQ GTPase cycle; RHOC GTPase cycle; RHOU GTPase cycle; RHOV GTPase cycle; Nephrin family interactions | 0.930229675308081 | 0.794460986683881 | 0.787568130909409 | 0.991639536226218 | 0.830676695521175 | 0.941920360687835 | 0.777195460870953 | 0.924682711624237 | 49243.316732893 | 68725.418758499 | 58984.367745696 | 969026.209101501 | 1404075.03080168 | 833592.785314498 | 1068898.0084058929 | 204266.486982725 | 334218.990287697 | 455010.844725875 | 331165.4406654323 | 4213732.69874793 | 3933999.53801573 | 3238797.72524118 | 3795509.9873349466 | 503563.00444482 | 1468565.36197421 | 860307.289081776 | 944145.2185002686 | |
| P52480 | Pyruvate kinase PKM [OS=Mus musculus] | 163.393 | 62 | 27 | 442 | 27 | 531 | 57.8 | cell organization and biogenesis;other metabolic processes;other biological processes | cytosol;ER/Golgi;nucleus;other cell component | nucleic acid binding activity;kinase activity;other molecular function | 18746 | ENSMUSG00000032294 | Pkm | mmu:18746; P52480; Q3TBV8; Q3TBW5; Q3TC59; Q3U1X3; Q3U5P6; Q4VC20; Q64484; Q91YI8; Q9CWB1 | Glycolysis and gluconeogenesis; Purine metabolism | Neutrophil degranulation; Pyruvate metabolism; Glycolysis; Regulation of pyruvate metabolism | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.938859506774495 | 0.972868731003358 | 0.958705855138011 | 0.959522188921769 | 312569.127047718 | 79336.1029165598 | 280190.614862653 | 224031.9482756436 | 2.13357824001936E7 | 1.96436562290884E7 | 9081648.29120601 | 1.6687028973496003E7 | 1.01259485831113E7 | 9467201.29798786 | 1.55257573035923E7 | 1.1706302394897154E7 | 3.31547939620584E7 | 3.43565739025104E7 | 2.75852274417617E7 | 3.1698865102110166E7 | 7722776.69094361 | 1.86748082798887E7 | 1.43901632993649E7 | 1.3595916090065738E7 |
| P63017 | Heat shock cognate 71 kDa protein [OS=Mus musculus] | 161.557 | 53 | 28 | 572 | 23 | 646 | 70.8 | cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component | signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function | 15481 | ENSMUSG00000015656 | Hspa8 | mmu:15481; P08109; P12225; P63017; Q3U6R0; Q3U764; Q3U7D7; Q3U7E2; Q3U9B4; Q3U9G0; Q3UGM0; Q5FWJ6; Q62373; Q62374; Q62375; Q6NZD0 | Mapk signaling pathway; Exercise-induced circadian regulation | Neutrophil degranulation; mRNA Splicing - Major Pathway; Regulation of HSF1-mediated heat shock response; PKR-mediated signaling; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis; Attenuation phase; Lysosome Vesicle Biogenesis; GABA synthesis, release, reuptake and degradation; AUF1 (hnRNP D0) binds and destabilizes mRNA; Protein methylation | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.987939278265184 | 0.953011140807089 | 0.709593139419252 | 0.587315224195015 | 247063.168316828 | 221267.865667273 | 228333.997143376 | 232221.67704249235 | 2.34302361722569E7 | 1.91610816116977E7 | 2.44529780700925E7 | 2.2348098618015703E7 | 1.52458610795295E7 | 1.21057626921531E7 | 1.98188188374949E7 | 1.5723480869725833E7 | 4.35786305197153E7 | 3.523488629513E7 | 2.44125225303247E7 | 3.440867978172333E7 | 9679200.3009757 | 1.32405397257932E7 | 1.30838270231471E7 | 1.2001189016638666E7 |
| Q9JHU4 | Cytoplasmic dynein 1 heavy chain 1 [OS=Mus musculus] | 161.009 | 14 | 55 | 258 | 55 | 4644 | 531.7 | cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes | cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 13424 | ENSMUSG00000018707 | Dync1h1 | E9QM71; mmu:13424; Q9JHU4 | MHC class II antigen presentation; Neutrophil degranulation; Separation of Sister Chromatids; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; COPI-mediated anterograde transport; Recruitment of NuMA to mitotic centrosomes; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-independent Golgi-to-ER retrograde traffic; Aggrephagy; Anchoring of the basal body to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; AURKA Activation by TPX2 | 0.591873375996003 | 0.826895204418257 | 0.758743075163871 | 0.936818656936794 | 0.771389136401717 | 0.987352798667733 | 0.695927216301667 | 0.953305976192702 | 224060.75101347 | 288932.991027563 | 370866.333925136 | 294620.0253220563 | 1035717.43113769 | 1898525.78207622 | 892363.147243056 | 1275535.4534856554 | 298543.620628635 | 395801.785314415 | 659710.172961205 | 451351.8596347517 | 5741364.17159479 | 5412980.23144293 | 4332188.15134028 | 5162177.518126 | 1219184.02821873 | 1626625.47525789 | 1541170.38578568 | 1462326.6297541 | |
| Q99K41 | EMILIN-1 [OS=Mus musculus] | 157.011 | 31 | 21 | 244 | 21 | 1017 | 107.5 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 100952 | ENSMUSG00000029163 | Emilin1 | mmu:100952; Q99K41 | Molecules associated with elastic fibres | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.169879542413978 | 0.64186124184599 | 0.0921665663508908 | 0.491906845171331 | 6287128.66260445 | 6034831.78772075 | 4173278.84836641 | 5498413.09956387 | 1744058.35010072 | 1513530.29654839 | 1757558.94039384 | 1671715.86234765 | 2698540.13579468 | 2559754.7470142 | 1836473.80243277 | 2364922.89508055 | 286714.652107864 | 495091.120602366 | 371444.218276851 | 384416.66366236034 | |||||
| Q61879 | Myosin-10 [OS=Mus musculus] | 146 | 19 | 31 | 236 | 20 | 1976 | 228.9 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;nucleic acid binding activity;other molecular function | 77579 | ENSMUSG00000020900 | Myh10 | mmu:77579; Q5SV63; Q61879 | Regulation of actin cytoskeleton | RHO GTPases activate PAKs | 0.705689538076567 | 0.506231596289679 | 0.676239752697828 | 0.933545599871938 | 0.996007724449986 | 0.990096171400123 | 0.953146340313072 | 0.921444667457376 | 132922.802732814 | 81410.1821075416 | 155803.703539863 | 123378.89612673952 | 578601.376274227 | 569525.366217458 | 228469.06472958 | 458865.269073755 | 249877.75631 | 195698.454667987 | 352494.602688902 | 266023.60455562966 | 1222751.03080206 | 1020719.46631895 | 1025108.65415173 | 1089526.38375758 | 489393.525760184 | 539451.948957579 | 659882.564109888 | 562909.3462758837 |
| Cont_P00761 | Trypsin OS=Sus scrofa OX=9823 PE=1 SV=1 | 143.502 | 62 | 11 | 3859 | 10 | 231 | 24.4 | protein metabolism;other biological processes | non-structural extracellular | other molecular function | 0.254996071775817 | 0.172153475402034 | 0.357784551188889 | 0.34040294575649 | 0.822223648478518 | 0.740968241512781 | 0.960577895552113 | 0.148582186670595 | 5.17896971017178E9 | 5.13317471139103E9 | 7.27761160813741E9 | 5.863252009900073E9 | 2.70973552724487E9 | 1.73168232498425E9 | 2.0962236592694E9 | 2.1792138371661735E9 | 3.08554430734093E9 | 3.85764460784296E9 | 3.06099934235171E9 | 3.334729419178533E9 | 1.42194297351806E9 | 1.8379662886425E9 | 3.81973460995747E9 | 2.35988129070601E9 | 5.3849654871275E9 | 2.81761370832162E9 | 5.23567407489624E9 | 4.479417756781787E9 | ||||||
| P20029 | Endoplasmic reticulum chaperone BiP [OS=Mus musculus] | 142.966 | 48 | 25 | 434 | 23 | 655 | 72.4 | protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component | enzyme regulator activity;translation activity;other molecular function | 14828 | ENSMUSG00000026864 | Hspa5 | mmu:14828; O35642; P20029; Q3UFF2; Q61630 | Mapk signaling pathway | Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Regulation of HSF1-mediated heat shock response | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.916283277860523 | 0.769590657123576 | 0.985707795620743 | 0.888702680095366 | 7850142.93480902 | 7648809.53150357 | 9169945.31743656 | 8222965.927916382 | 7535475.80605118 | 5802650.52918468 | 8839942.11003441 | 7392689.481756757 | 1.89485602512479E7 | 1.6006905998567E7 | 1.24118184289709E7 | 1.57890948929286E7 | 7216046.0503345 | 9459779.49149077 | 8533209.24248049 | 8403011.594768586 | ||||
| Cont_P13647 | Keratin, type II cytoskeletal 5 OS=Homo sapiens OX=9606 GN=KRT5 PE=1 SV=3 | 142.395 | 51 | 34 | 500 | 20 | 590 | 62.3 | cell organization and biogenesis;other biological processes | cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;cytoskeletal activity;other molecular function | 3852 | ENSG00000186081 | KRT5 | hsa:3852; P13647; Q6PI71; Q6UBJ0; Q8TA91 | Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin; Developmental Lineage of Mammary Stem Cells; Developmental Lineage of Mammary Gland Myoepithelial Cells; Type I hemidesmosome assembly | 0.786915923361782 | 0.847457711018997 | 0.707170943024881 | 0.746833150482801 | 0.873755746039336 | 0.714156118974909 | 0.2733017775894 | 2.49132633766938E-5 | 5120503.46953844 | 5171426.92187225 | 6553368.21772984 | 5615099.536380176 | 9669299.63907403 | 1.1127930529353E7 | 9127716.50969809 | 9974982.226041706 | 9513581.76230213 | 7584977.17814252 | 6506980.60696686 | 7868513.182470503 | 1.59683716443188E7 | 1.28154121523541E7 | 1.32126695164861E7 | 1.3998817771053001E7 | 1.8678004759752E7 | 1.36191738010446E7 | 5.39600661696836E7 | 2.8752414910160065E7 | |
| Cont_P08779 | Keratin, type I cytoskeletal 16 OS=Homo sapiens OX=9606 GN=KRT16 PE=1 SV=4 | 140.751 | 54 | 25 | 569 | 12 | 473 | 51.2 | cell organization and biogenesis;stress response;other biological processes | plasma membrane;cytosol;cytoskeleton | cytoskeletal activity | 3868 | ENSG00000186832 | KRT16 | A8K488; hsa:3868; P08779; P30654; Q16402; Q9UBG8 | Vitamin D receptor pathway | Formation of the cornified envelope | 0.941324060398065 | 0.961351301268194 | 0.761460393544015 | 0.887279041944908 | 0.82543231800733 | 0.493923182294169 | 0.895302208460818 | 3.1065941501805E-4 | 1047544.82178002 | 1389728.97312405 | 1389730.63830375 | 1275668.1444026066 | 1501449.09449526 | 2307427.01338473 | 2939547.44501319 | 2249474.51763106 | 7196685.12946156 | 1715910.61220057 | 2812173.28112121 | 3908256.3409277797 | 4331979.12309994 | 1639569.64130669 | 1737373.70058763 | 2569640.8216647534 | 4434008.92515372 | 2223613.02167429 | 9547147.41410007 | 5401589.786976026 |
| Cont_P02465 | Collagen alpha-2(I) chain OS=Bos taurus OX=9913 GN=COL1A2 PE=1 SV=2 | 139.99 | 18 | 19 | 445 | 3 | 1364 | 129 | non-structural extracellular;extracellular matrix | extracellular structural activity;other molecular function | 282188 | ENSBTAG00000013472 | COL1A2 | A6QP13; bta:282188; O62649; P02465 | Inflammatory response pathway; Focal adhesion | Fibronectin matrix formation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Collagen degradation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; Collagen chain trimerization; GPVI-mediated activation cascade; Platelet Aggregation (Plug Formation); Platelet Adhesion to exposed collagen; GP1b-IX-V activation signalling | 0.483779141493222 | 0.876027096029978 | 0.421836754550416 | 0.488872343346086 | 0.731850662833984 | 0.076245756040016 | 0.549852418071669 | 0.432748651973214 | 80849.8235508145 | 93725.5578519836 | 35755.9745173747 | 70110.45197339094 | 170240.553800628 | 153570.468872413 | 167384.810476394 | 163731.944383145 | 78292.6458688874 | 70345.2867467554 | 108688.239366299 | 85775.39066064726 | 65032.7123193958 | 48396.6073357386 | 51482.0177898574 | 54970.44581499727 | 51011.1923790395 | 62191.0072542807 | 32903.9376967684 | 48702.045776696206 | |
| Cont_P12763 | Alpha-2-HS-glycoprotein OS=Bos taurus OX=9913 GN=AHSG PE=1 SV=2 | 132.772 | 50 | 16 | 1191 | 16 | 359 | 38.4 | stress response;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component | enzyme regulator activity | 280988 | AHSG | A6QLF7; bta:280988; P12763 | Neutrophil degranulation; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 0.573667790345329 | 0.793013134473823 | 0.624272910267193 | 0.36488675645736 | 0.946568086066385 | 0.268930374946741 | 0.335956814949331 | 0.913214993335179 | 6.75081036645858E8 | 9.56771805796805E8 | 4.32862555462728E8 | 6.882384659684638E8 | 6.04790296716478E8 | 6.42824998486085E8 | 6.76887564991134E8 | 6.41500953397899E8 | 8.54466282868744E8 | 8.4303805016043E8 | 9.16216503216691E8 | 8.712402787486216E8 | 7.41908408260606E8 | 7.48114705273509E8 | 6.29285280642112E8 | 7.064361313920757E8 | 3.42283489676807E8 | 6.64083343401506E8 | 3.25834950231514E8 | 4.440672611032756E8 | ||
| P07901 | Heat shock protein HSP 90-alpha [OS=Mus musculus] | 132.382 | 43 | 25 | 402 | 16 | 733 | 84.7 | cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component | signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function | 15519 | ENSMUSG00000021270 | Hsp90aa1 | mmu:15519; P07901 | EBV LMP1 signaling; Focal adhesion: PI3K-Akt-mTOR signaling pathway; IL-6 signaling pathway; IL-2 signaling pathway | Regulation of necroptotic cell death; Recruitment of NuMA to mitotic centrosomes; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of actin dynamics for phagocytic cup formation; Neutrophil degranulation; Downregulation of ERBB2 signaling; Anchoring of the basal body to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; AURKA Activation by TPX2; Extra-nuclear estrogen signaling; Attenuation phase; Estrogen-dependent gene expression; Sema3A PAK dependent Axon repulsion; VEGFR2 mediated vascular permeability; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation; DDX58/IFIH1-mediated induction of interferon-alpha/beta; eNOS activation; HSF1 activation; RHOBTB2 GTPase cycle; Drug-mediated inhibition of ERBB2 signaling | 1.65082956259427E-17 | 0.508730894200713 | 1.50457038391225E-17 | 0.251664970734015 | 0.974827674952665 | 0.788764875934969 | 0.968364585136618 | 0.745600589176001 | 51071.3130902855 | 169244.190500369 | 193833.457176882 | 138049.65358917884 | 3826029.08230807 | 4600695.96516161 | 3479662.10980986 | 3968795.71909318 | 1533159.7098775 | 1700635.66665037 | 1768278.53880507 | 1667357.9717776468 | 6471421.59388824 | 6122550.53993506 | 5450079.38924241 | 6014683.841021903 | 900341.190737514 | 2215799.13247972 | 1704183.40484156 | 1606774.576019598 |
| Q02819 | Nucleobindin-1 [OS=Mus musculus] | 131.152 | 51 | 21 | 299 | 21 | 459 | 53.4 | signal transduction | non-structural extracellular;other membranes;ER/Golgi | enzyme regulator activity;nucleic acid binding activity;other molecular function | 18220 | ENSMUSG00000030824 | Nucb1 | mmu:18220; Q02819; Q3TU42; Q9CWA1; Q9D8J4; Q9DBL3 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 0.130903496983571 | 0.0679830640731695 | 0.340647566778883 | 0.397987186613988 | 0.958122559708965 | 41072.7931792495 | 20198.6046706008 | 30635.69892492515 | 1.70846710933602E7 | 1.97547416617741E7 | 2.08807433533847E7 | 1.9240052036173E7 | 5757191.6972993 | 4828078.95450858 | 5895038.38978249 | 5493436.34719679 | 7136546.74332753 | 7387752.88718417 | 5120327.81590923 | 6548209.148806977 | 1130733.36645935 | 3369667.63744922 | 2637872.59598673 | 2379424.5332984333 | ||
| Q91V92 | ATP-citrate synthase [OS=Mus musculus] | 129.973 | 32 | 28 | 237 | 28 | 1091 | 119.7 | other metabolic processes | cytosol | other molecular function | 104112 | ENSMUSG00000020917 | Acly | mmu:104112; Q91V92 | Fatty acid biosynthesis | Neutrophil degranulation; Fatty acyl-CoA biosynthesis | 0.230775890814232 | 0.371468864113786 | 0.437429424171984 | 0.509570119936397 | 0.626059420687734 | 0.98558531112136 | 0.643183834410259 | 0.922580167429744 | 8856.99380706579 | 32765.2400642807 | 40990.0091117865 | 27537.414327710998 | 2382723.31982566 | 2481678.51703659 | 2154876.39410613 | 2339759.4103227933 | 1256305.5375454 | 885993.369046538 | 1688459.92743218 | 1276919.6113413726 | 2057502.05407172 | 1815562.79058184 | 1460220.9588277 | 1777761.9344937534 | 534991.757912276 | 802971.776166877 | 594587.914542531 | 644183.8162072281 |
| A2ASQ1 | Agrin [OS=Mus musculus] | 128.989 | 18 | 26 | 227 | 26 | 1950 | 207.4 | cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cell component | signal transduction activity or receptor binding;other molecular function | 11603 | ENSMUSG00000041936 | Agrn | A2ASP9; A2ASQ0; A2ASQ1; B2RWU1 | Primary focal segmental glomerulosclerosis (FSGS) | ECM proteoglycans; Retinoid metabolism and transport; Glycosaminoglycan-protein linkage region biosynthesis; HS-GAG biosynthesis; HS-GAG degradation; Formation of the dystrophin-glycoprotein complex (DGC) | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.460727828548759 | 0.972791368602389 | 0.686318824668434 | 0.846971399004193 | 2612028.52511147 | 3116500.52541199 | 3328171.1398056 | 3018900.06344302 | 1818519.74579979 | 1551006.46226864 | 1715477.48863677 | 1695001.2322350666 | 2313945.16119856 | 2044906.61336417 | 1778324.63596447 | 2045725.4701757336 | 632566.873707257 | 1496109.18442141 | 957812.214242183 | 1028829.4241236168 | ||||
| Q61508 | Extracellular matrix protein 1 [OS=Mus musculus] | 127.379 | 45 | 18 | 358 | 18 | 559 | 62.8 | stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular | signal transduction activity or receptor binding;other molecular function | 13601 | ENSMUSG00000028108 | Ecm1 | mmu:13601; Q3U5Q5; Q61508 | Platelet degranulation | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 0.121600547823456 | 2.27890527565265E-4 | 0.795351011232032 | 1.51989274634622E-7 | 0.592370654746194 | 110159.96586707 | 68619.5270607555 | 45654.6843175291 | 74811.39241511819 | 5.6443097497098E7 | 7.11751205740166E7 | 5.82782830048746E7 | 6.196550035866306E7 | 5.1935854689884E7 | 4.50204039942893E7 | 5.70225374161979E7 | 5.132626536679041E7 | 1.27540105597053E7 | 1.25514774649527E7 | 8690203.83604475 | 1.1331897286900917E7 | 2192350.97546663 | 4663417.73981907 | 3690111.31703252 | 3515293.344106073 | |
| Cont_P04259 | Keratin, type II cytoskeletal 6B OS=Homo sapiens OX=9606 GN=KRT6B PE=1 SV=5 | 126.901 | 47 | 30 | 442 | 4 | 564 | 60 | cell organization and biogenesis;other biological processes | cytosol;cytoskeleton | bone, tooth or skin structural activity;cytoskeletal activity | 3854 | ENSG00000185479 | KRT6B | hsa:3854; P04259; P48669 | Formation of the cornified envelope | 0.857251372850113 | 0.868132360832926 | 0.758743075163871 | 0.801271130817871 | 0.854305439376382 | 0.340133476321195 | 0.937453377971347 | 0.00123883404563536 | 267279.779286483 | 355493.362381868 | 274137.281616349 | 298970.1410949 | 326989.588402741 | 585438.697100962 | 617622.938974811 | 510017.07482617133 | 2390973.53573307 | 430931.486741926 | 646270.614315847 | 1156058.5455969477 | 1869779.42318807 | 346417.77494154 | 348508.009299423 | 854901.7358096777 | 1155463.67620058 | 538093.594898596 | 1653754.7898307 | 1115770.6869766254 | |
| P17182 | Alpha-enolase [OS=Mus musculus] | 126.804 | 60 | 19 | 244 | 16 | 434 | 47.1 | other metabolic processes;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;other cell component | nucleic acid binding activity;other molecular function | 13806; 433182 | ENSMUSG00000059040; ENSMUSG00000063524 | Eno1 | mmu:13806; mmu:433182; P17182; Q99KT7; Q9DCY7 | Glycolysis and gluconeogenesis | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.720832939248489 | 0.789540446904924 | 0.858218537342417 | 0.989544231571828 | 31098.019126098 | 70318.9502605952 | 40658.6319347469 | 47358.53377381337 | 1.28655809626545E7 | 1.34726279447959E7 | 7101469.5445256 | 1.1146559483992001E7 | 9089751.86845938 | 7552189.93174957 | 1.17772011823713E7 | 9473047.660860082 | 3.50544676757808E7 | 2.99447661492486E7 | 2.18255690502528E7 | 2.89416009584274E7 | 1.11532480577619E7 | 1.75489228796712E7 | 1.30151947674988E7 | 1.3905788568310633E7 | |
| P08113 | Endoplasmin [OS=Mus musculus] | 126.346 | 39 | 26 | 329 | 25 | 802 | 92.4 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cell component | signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function | 22027 | ENSMUSG00000020048 | Hsp90b1 | mmu:22027; P08113; P11427 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Hypoxia-dependent self-renewal of myoblasts | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Scavenging by Class A Receptors; Trafficking and processing of endosomal TLR; Interleukin-4 and Interleukin-13 signaling | 0.107476768049312 | 0.0104456807471941 | 1.50457038391225E-17 | 0.205304099107124 | 0.854305439376382 | 0.840785133352029 | 0.866766165039268 | 0.896996950298791 | 75656.6139115948 | 52183.5314261123 | 29905.9702816436 | 52582.03853978356 | 5932785.14172209 | 5786569.94317903 | 3299962.37110113 | 5006439.15200075 | 3817668.17887426 | 3366255.7650389 | 4907428.60350699 | 4030450.84914005 | 1.47606948013545E7 | 1.21020755462977E7 | 1.0441016038914E7 | 1.2434595462188734E7 | 3792376.91369813 | 7854793.82920015 | 6464144.86133097 | 6037105.20140975 |
| P58252 | Elongation factor 2 [OS=Mus musculus] | 126.048 | 37 | 31 | 378 | 30 | 858 | 95.3 | cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;translational apparatus;other cell component | cytoskeletal activity;translation activity;nucleic acid binding activity;other molecular function | 13629 | ENSMUSG00000034994 | Eef2 | mmu:13629; P58252; Q544E4 | Translation factors | Neutrophil degranulation; Protein methylation; Peptide chain elongation; Synthesis of diphthamide-EEF2 | 0.299809054080284 | 0.188334321166369 | 0.471929633209224 | 0.84258396038376 | 0.922179983282929 | 0.97504218639442 | 0.866546043492515 | 0.950878070645738 | 275529.241689771 | 247076.7728808 | 166294.142173825 | 229633.38558146535 | 1.22498155967913E7 | 1.26488626480754E7 | 6800245.14611723 | 1.0566307796994643E7 | 5717562.35282925 | 5172569.64432748 | 8352282.82529915 | 6414138.274151959 | 1.55667000517401E7 | 1.33925688878402E7 | 1.02378508629272E7 | 1.3065706600835832E7 | 2972661.18095993 | 6421886.97759523 | 5184391.52691505 | 4859646.5618234025 |
| Cont_P02538 | Keratin, type II cytoskeletal 6A OS=Homo sapiens OX=9606 GN=KRT6A PE=1 SV=3 | 123.757 | 47 | 30 | 454 | 3 | 564 | 60 | cell organization and biogenesis;stress response;other biological processes | cytosol;cytoskeleton | bone, tooth or skin structural activity;cytoskeletal activity | 3853 | ENSG00000205420 | KRT6A | A4QPC1; hsa:3853; P02538; P48667; Q08AR4; Q6NT67; Q96CL4 | Ectoderm differentiation; Ectoderm differentiation; Pancreatic cancer subtypes | Formation of the cornified envelope | 0.892533464536408 | 0.964633336683333 | 0.745886066139481 | 0.84258396038376 | 0.792564971776066 | 0.574739141583974 | 0.709593139419252 | 5.66461038960431E-4 | 2017098.82314832 | 2171650.09464557 | 2359880.73116726 | 2182876.549653717 | 2825309.68904382 | 4320098.03084773 | 4192074.59940388 | 3779160.7730984767 | 8075888.41129776 | 2685265.07688442 | 3594101.84504227 | 4785085.111074816 | 5878699.8667026 | 3215829.01184206 | 2854010.96069105 | 3982846.61307857 | 8158147.16608847 | 4198498.19802621 | 1.30998597349634E7 | 8485501.699692694 |
| P97298 | Pigment epithelium-derived factor [OS=Mus musculus] | 123.502 | 47 | 16 | 346 | 12 | 417 | 46.2 | cell cycle OR cell proliferation;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | enzyme regulator activity | 20317 | ENSMUSG00000000753 | Serpinf1 | mmu:20317; O70629; O88691; P97298 | 1.65082956259427E-17 | 0.227296093012204 | 0.434748506750565 | 0.770205086382264 | 0.00901230529014985 | 0.174886032348437 | 0.300753028734261 | 0.891044455497809 | 554016.1710638 | 470705.490372182 | 363015.858993357 | 462579.17347644636 | 5.24905837082578E7 | 7.20656975211191E7 | 8.90978835263609E7 | 7.121805491857927E7 | 1.55195541438312E7 | 1.33807646088142E7 | 1.504676823338E7 | 1.46490289953418E7 | 1.63245792137601E7 | 1.5700230598517E7 | 1.5246806329463E7 | 1.5757205380580032E7 | 3869051.7420588 | 8996988.40278734 | 4897006.93274029 | 5921015.69252881 | ||
| Q70E20 | Sushi, nidogen and EGF-like domain-containing protein 1 [OS=Mus musculus] | 122.942 | 19 | 22 | 287 | 22 | 1403 | 151.5 | cell adhesion | non-structural extracellular;extracellular matrix | other molecular function | 208777 | Sned1 | A6H6I3; mmu:208777; Q70E20; Q810H2; Q8BMD9 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.889058672589993 | 0.869908412860824 | 0.817293288705596 | 0.880760468933162 | 62940.5062355012 | 25184.2741656831 | 25459.8187779288 | 37861.533059704365 | 7879183.70581794 | 8304827.25748066 | 2617617.70526214 | 6267209.5561869135 | 3110990.0320528 | 3263544.92621848 | 3507274.08693078 | 3293936.3484006864 | 1.72480350493842E7 | 1.48489121993504E7 | 1.05732378776404E7 | 1.4223395042125002E7 | 2537287.1447922 | 7075122.99473268 | 5373074.41423662 | 4995161.517920501 | |||
| P13020 | Gelsolin [OS=Mus musculus] | 122.934 | 35 | 22 | 377 | 9 | 780 | 85.9 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 227753 | ENSMUSG00000026879 | Gsn | mmu:227753; P13020; Q3UPB1; Q8R590 | Regulation of actin cytoskeleton | Neutrophil degranulation; Caspase-mediated cleavage of cytoskeletal proteins | 0.440427841758307 | 0.396306424610341 | 0.186266168629733 | 0.379422692457324 | 0.65414435708462 | 0.994546642862744 | 0.709593139419252 | 0.793590033024783 | 1154075.61374729 | 1486973.5078743 | 778278.604931373 | 1139775.9088509877 | 1.0611315000974E7 | 9755419.92114226 | 9110194.21443976 | 9825643.045518672 | 6039243.17546894 | 5549542.61366164 | 7725308.54354706 | 6438031.44422588 | 3.63344365935893E7 | 2.77403609084757E7 | 2.33574049877416E7 | 2.9144067496602204E7 | 8417203.0170929 | 1.43392014575414E7 | 1.03453705657478E7 | 1.1033925013460701E7 |
| Q61398 | Procollagen C-endopeptidase enhancer 1 [OS=Mus musculus] | 120.4 | 40 | 14 | 323 | 14 | 468 | 50.1 | protein metabolism;other biological processes | enzyme regulator activity;other molecular function | 18542 | ENSMUSG00000029718 | Pcolce | mmu:18542; O35113; Q61398 | mRNA processing | Collagen biosynthesis and modifying enzymes; Crosslinking of collagen fibrils | 1.65082956259427E-17 | 1.8644578313253E-17 | 0.151224536345852 | 0.288320039261486 | 0.133905327763598 | 0.789540446904924 | 0.0895861566882082 | 0.711902858921665 | 55825.2363051742 | 84655.3590880939 | 113029.200120433 | 84503.2651712337 | 3.10244208090572E7 | 2.97623271730106E7 | 2.79757713270171E7 | 2.958750643636163E7 | 2.72578314339105E7 | 2.28908828526637E7 | 2.54654481194513E7 | 2.52047208020085E7 | 1.54882233602667E7 | 1.24902767859117E7 | 9636426.2851997 | 1.2538308810459368E7 | 5125325.32901055 | 9907837.52014591 | 7984547.74798259 | 7672570.19904635 | |
| P26039 | Talin-1 [OS=Mus musculus] | 118.226 | 15 | 30 | 153 | 30 | 2541 | 269.7 | cell adhesion;cell organization and biogenesis;signal transduction | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;other molecular function | 21894 | ENSMUSG00000028465 | Tln1 | A2AIM8; mmu:21894; P26039; Q8VEF0 | Primary focal segmental glomerulosclerosis (FSGS); Integrin-mediated cell adhesion; Focal adhesion | Platelet degranulation ; MAP2K and MAPK activation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; Smooth Muscle Contraction; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 0.958262397335385 | 0.994542145304377 | 0.680632778351053 | 0.738983404380581 | 0.850917681937748 | 0.783910800136359 | 0.87222702623065 | 0.535066779633529 | 137218.697336797 | 64798.4580467583 | 241653.653741064 | 147890.2697082064 | 580168.664793601 | 803244.58151111 | 320387.746187394 | 567933.664164035 | 118081.406885094 | 124079.798936285 | 255551.526824265 | 165904.24421521465 | 2877993.84785898 | 2114900.66089323 | 1881659.61273992 | 2291518.0404973766 | 240671.449108311 | 385063.079961369 | 234819.255172709 | 286851.2614141297 |
| Q8BPB5 | EGF-containing fibulin-like extracellular matrix protein 1 [OS=Mus musculus] | 117.738 | 49 | 15 | 220 | 15 | 493 | 54.9 | protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes | extracellular matrix | signal transduction activity or receptor binding;kinase activity;other molecular function | 216616 | ENSMUSG00000020467 | Efemp1 | mmu:216616; Q6Y3N6; Q8BPB5 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 0.376780684027729 | 0.278244203695445 | 0.983440558239231 | 0.145805028390539 | 0.982581944728745 | 15298.8221438323 | 19141.8575027524 | 55545.7753728227 | 29995.485006469138 | 7090020.68988726 | 8805500.10345141 | 5126350.07183034 | 7007290.288389671 | 4435222.67421531 | 4392813.74676133 | 4496081.41897935 | 4441372.613318663 | 4016966.57007158 | 3984703.05528875 | 2817881.79753384 | 3606517.1409647237 | 682456.349264741 | 1966499.77195883 | 1462163.85427198 | 1370373.3251651835 | ||
| P09411 | Phosphoglycerate kinase 1 [OS=Mus musculus] | 116.462 | 57 | 18 | 287 | 18 | 417 | 44.5 | protein metabolism;other metabolic processes;stress response;other biological processes | non-structural extracellular;other membranes;cytosol;mitochondrion;other cell component | kinase activity;other molecular function | 18655 | ENSMUSG00000062070 | Pgk1 | mmu:18655; P09411; Q3TPE6; Q3UKV8; Q5XJE7 | Glycolysis and gluconeogenesis | Gluconeogenesis; Glycolysis | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.465126095372736 | 0.766862952867809 | 0.820281310709571 | 0.891044455497809 | 78089.4641074341 | 38741.0917691314 | 23421.0514741904 | 46750.53578358531 | 4316274.39280249 | 5023293.68471847 | 1442874.888393 | 3594147.655304653 | 2829873.33459098 | 2934698.045784 | 3868274.47312523 | 3210948.6178334034 | 1.65254946701665E7 | 1.56270051770472E7 | 1.22346365889796E7 | 1.4795712145397767E7 | 2315853.03926933 | 6654180.61411261 | 4530199.20599689 | 4500077.619792943 |
| P27773 | Protein disulfide-isomerase A3 [OS=Mus musculus] | 115.891 | 55 | 23 | 291 | 23 | 505 | 56.6 | cell adhesion;cell organization and biogenesis;stress response;signal transduction;other biological processes | non-structural extracellular;other membranes;ER/Golgi;other cell component | nucleic acid binding activity;other molecular function | 14827 | ENSMUSG00000027248 | Pdia3 | mmu:14827; P27773; Q3TEI9; Q3TIL2; Q3UZK8; Q8C2F4; Q99LF6 | ER-Phagosome pathway; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Calnexin/calreticulin cycle | 0.9135584231482 | 0.736536116100563 | 0.498293621965442 | 0.874168055361729 | 0.850917681937748 | 0.862063111456553 | 0.881496352314601 | 0.939046770372612 | 206281.038958907 | 253939.7116523 | 128510.108086966 | 196243.61956605766 | 6669793.66068216 | 7133803.24141356 | 5637352.69437344 | 6480316.532156386 | 5319375.96186612 | 3844376.07822282 | 6321729.00885173 | 5161827.016313557 | 1.83298906806341E7 | 1.50101054148645E7 | 1.26051366299531E7 | 1.5315044241817234E7 | 6059857.55300524 | 8984695.03809976 | 6670485.36185494 | 7238345.98431998 | |
| P10107 | Annexin A1 [OS=Mus musculus] | 115.566 | 64 | 18 | 270 | 18 | 346 | 38.7 | cell organization and biogenesis;stress response;transport;signal transduction;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component | enzyme regulator activity;other molecular function | 16952 | ENSMUSG00000024659 | Anxa1 | mmu:16952; P10107 | Spinal cord injury; Prostaglandin synthesis and regulation | G alpha (q) signalling events; G alpha (i) signalling events; Formyl peptide receptors bind formyl peptides and many other ligands | 1.65082956259427E-17 | 0.105053536950499 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.954328834404239 | 0.401885831342676 | 0.529099828181544 | 0.924766494197286 | 13280.9290610842 | 9160.53166722029 | 4508.77124840677 | 8983.410658903753 | 5251880.61554565 | 6740833.31198439 | 6058745.6526555 | 6017153.19339518 | 1560362.01883491 | 1521121.84391776 | 1946127.08618424 | 1675870.316312303 | 1.11990207127477E7 | 1.0990927807692E7 | 1.0321301103113E7 | 1.08370832078509E7 | 3223846.7434476 | 4805492.80063037 | 4605609.45936174 | 4211649.667813237 |
| Cont_Q2KJF1 | Alpha-1B-glycoprotein OS=Bos taurus OX=9913 GN=A1BG PE=1 SV=1 | 115.502 | 48 | 14 | 224 | 14 | 503 | 53.5 | signal transduction | non-structural extracellular;plasma membrane;other membranes | 518955 | A1BG | bta:518955; Q2KJF1 | Platelet degranulation ; Neutrophil degranulation | 0.635218461842139 | 0.655487072215252 | 0.641514600397631 | 0.360991986803736 | 0.932231143665149 | 0.696358249006924 | 0.601376052147163 | 0.891044455497809 | 1.12339445909494E7 | 1.09217008752481E7 | 5999938.28834399 | 9385194.584847162 | 7597724.26810103 | 8696294.29830821 | 1.02832125493257E7 | 8859077.038578315 | 1.08372253099689E7 | 9914324.88654618 | 8710997.51604168 | 9820849.23751892 | 1.11963323092602E7 | 9450705.94975847 | 1.03053408353504E7 | 1.0317459698123023E7 | 5535891.07899516 | 9467766.08082133 | 5283853.74244175 | 6762503.63408608 | |||
| Cont_Q3MHN5 | Vitamin D-binding protein OS=Bos taurus OX=9913 GN=GC PE=2 SV=1 | 113.599 | 55 | 20 | 319 | 20 | 474 | 53.3 | other metabolic processes;transport | non-structural extracellular;other cell component | transporter activity;cytoskeletal activity;other molecular function | 530076 | GC | bta:530076; Q3MHN5 | 0.549057967251154 | 0.804331105646976 | 0.579435037816218 | 0.479472599858427 | 0.946173787415917 | 0.139718417146003 | 0.570795727084329 | 0.421365656927814 | 1.55879441314789E7 | 1.53074066841615E7 | 7458694.29508707 | 1.2784681703575822E7 | 1.04365108192777E7 | 1.20620475306269E7 | 8309099.82300618 | 1.026921939097026E7 | 1.67215053413279E7 | 1.54231806136738E7 | 1.57780518794517E7 | 1.5974245944817802E7 | 1.6556516146824E7 | 1.52311500265876E7 | 1.20681229464E7 | 1.4618596373270534E7 | 9478628.98672491 | 1.47438110125204E7 | 8133055.93664235 | 1.0785165311962552E7 | |||
| P17742 | Peptidyl-prolyl cis-trans isomerase A [OS=Mus musculus] | 113.527 | 60 | 9 | 369 | 9 | 164 | 18 | cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes | non-structural extracellular;cytosol;nucleus;other cell component | signal transduction activity or receptor binding;other molecular function | 268373 | ENSMUSG00000071866 | Ppia | mmu:268373; P17742; Q9CWJ5; Q9R137 | Neutrophil degranulation; Basigin interactions | 0.100219677394751 | 0.099382125133403 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.946239447314336 | 0.696358249006924 | 0.937453377971347 | 0.331144967260478 | 1.16891341386391E7 | 754837.409863468 | 4157779.88062054 | 5533917.143041036 | 2.9189343463191E7 | 2.94929696895869E7 | 4.96473559496876E7 | 3.610988970082183E7 | 1.04342545713823E7 | 8178713.43858634 | 1.18234267071803E7 | 1.0145464905716315E7 | 4.91534751033825E7 | 4.2865019365108E7 | 4.61937263356195E7 | 4.607074026803666E7 | 7275434.18699702 | 1.51319991253865E7 | 9682919.1999608 | 1.0696784170781441E7 | |
| Q69ZN7 | Myoferlin [OS=Mus musculus] | 112.647 | 22 | 36 | 227 | 36 | 2048 | 233.2 | cell organization and biogenesis;other metabolic processes;stress response;other biological processes | plasma membrane;other membranes;nucleus | other molecular function | 226101 | ENSMUSG00000048612 | Myof | mmu:226101; Q69ZN7; Q7TMG0; Q80V33; Q8BU64; Q8BU70; Q8BUC1; Q8BVY6; Q8C0D1; Q8R3B4 | 0.73657372909066 | 0.964709887217926 | 0.888974672311279 | 0.930955411749965 | 0.816275429153737 | 0.877818946381645 | 0.609903091678244 | 0.975029032316037 | 86000.3771233404 | 87234.2597428081 | 50456.7230101595 | 74563.786625436 | 780930.944201502 | 985609.680593147 | 968573.73043394 | 911704.7850761963 | 296294.389327177 | 289800.794039455 | 380995.072506467 | 322363.41862436634 | 3324626.35891918 | 3238695.05806667 | 2634093.62813707 | 3065805.015040973 | 993761.586050851 | 1295229.11918404 | 1025817.2029614 | 1104935.9693987637 | ||
| P26041 | Moesin [OS=Mus musculus] | 112.068 | 47 | 28 | 353 | 19 | 577 | 67.7 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function | 17698 | ENSMUSG00000031207 | Msn | B1AX70; mmu:17698; P26041; Q3UL28; Q8BSN4 | Regulation of actin cytoskeleton | Recycling pathway of L1 | 1.65082956259427E-17 | 0.0604972675946614 | 1.50457038391225E-17 | 0.157138696252226 | 0.910750689050232 | 0.682171843898269 | 0.97925982662951 | 0.954396180425051 | 3509434.20481405 | 4360753.56845675 | 2823311.97478394 | 3564499.916018247 | 1.57847182977139E7 | 1.58696599538661E7 | 1.95033967654703E7 | 1.7052591672350097E7 | 8383545.44173348 | 7552431.53754312 | 1.1473115873696E7 | 9136364.2843242 | 2.43209045148915E7 | 1.7265255344344E7 | 1.55060800034236E7 | 1.9030746620886367E7 | 1.24969658442338E7 | 1.31486313258361E7 | 7954804.76477835 | 1.120013397828275E7 |
| P05064 | Fructose-bisphosphate aldolase A [OS=Mus musculus] | 112.015 | 66 | 18 | 261 | 18 | 364 | 39.3 | cell organization and biogenesis;other metabolic processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | other molecular function | 11674 | ENSMUSG00000030695 | Aldoa | mmu:11674; P05064 | Glycolysis and gluconeogenesis | Platelet degranulation ; Neutrophil degranulation; Gluconeogenesis; Glycolysis | 0.101571037453114 | 0.00616383846364181 | 1.50457038391225E-17 | 0.0771819601934254 | 0.907383519445145 | 0.828577692034317 | 0.988377544628277 | 0.953305976192702 | 36553.7681309936 | 18014.3910425567 | 11156.0078725057 | 21908.055682018665 | 5538849.24179232 | 5285372.3367409 | 3856062.26656154 | 4893427.94836492 | 4263443.39983126 | 3386915.16711964 | 5306808.16889341 | 4319055.57861477 | 1.24814165546298E7 | 1.09515793948855E7 | 8528808.13475854 | 1.0653934694757948E7 | 4075248.71161469 | 5289067.55868911 | 4192052.54158905 | 4518789.603964283 |
| B2RQC6 | Multifunctional protein CAD [OS=Mus musculus] | 111.853 | 18 | 32 | 111 | 32 | 2225 | 243.1 | other metabolic processes;stress response;transport;developmental processes;other biological processes | cytosol;nucleus;other cell component | kinase activity;other molecular function | 69719 | ENSMUSG00000013629 | Cad | B2RQC6; B7ZN27; mmu:69719 | Mechanisms associated with pluripotency | Pyrimidine biosynthesis | 0.69394578118832 | 0.6681512188534 | 0.666244110962191 | 0.963127218853016 | 0.340675523776301 | 0.968897093792999 | 0.798180783050573 | 0.621633895543644 | 55886.6384121637 | 12993.9975368397 | 34438.2113153553 | 34439.61575478624 | 1026045.60319635 | 1025412.85494839 | 821784.178770446 | 957747.5456383955 | 383358.762218724 | 322831.339780162 | 640190.890369534 | 448793.6641228067 | 516093.312619156 | 478923.162373783 | 363366.537093714 | 452794.3373622177 | 110686.677299138 | 180829.981634378 | 127462.003140709 | 139659.55402474166 |
| Q8BND5 | Sulfhydryl oxidase 1 [OS=Mus musculus] | 111.186 | 35 | 22 | 242 | 22 | 748 | 82.7 | cell organization and biogenesis;other biological processes | non-structural extracellular;other membranes;ER/Golgi | other molecular function | 104009 | ENSMUSG00000033684 | Qsox1 | mmu:104009; Q3TDY9; Q3TE19; Q3TR29; Q3UEL4; Q8BND5; Q8K041; Q9DBL6 | Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Neutrophil degranulation | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 0.162753188077458 | 0.203109767081086 | 0.696358249006924 | 0.331332346840573 | 0.877612009404373 | 40119.4404166161 | 10016.9610840251 | 25068.200750320597 | 9134645.28263017 | 1.19624109837519E7 | 1.04856878607794E7 | 1.052758137572049E7 | 3750508.26959308 | 3765475.87858746 | 4032369.19900008 | 3849451.1157268733 | 5503994.64256118 | 5774708.06447186 | 3841814.38132964 | 5040172.36278756 | 1169677.75963505 | 2786812.01379908 | 1498357.95430882 | 1818282.5759143168 |
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| Accession | Description | Sum PEP Score | Coverage [%] | # Peptides | # PSMs | # Unique Peptides | # AAs | MW [kDa] | Biological Process | Cellular Component | Molecular Function | Entrez Gene ID | Ensembl Gene ID | Gene Symbol | Gene ID | WikiPathways | Reactome Pathways | Abundance Ratio Adj. P-Value: (LQ_16h) / (FM) | Abundance Ratio Adj. P-Value: (LQ_6h) / (FM) | Abundance Ratio Adj. P-Value: (SQ_16h) / (FM) | Abundance Ratio Adj. P-Value: (SQ_6h) / (FM) | Abundance Ratio Adj. P-Value: (LQ_16h) / (LQ_6h) | Abundance Ratio Adj. P-Value: (SQ_6h) / (LQ_6h) | Abundance Ratio Adj. P-Value: (SQ_16h) / (SQ_6h) | FM_AVERAGE | LQ6h_AVERAGE | LQ16h_AVERAGE | SQ6h_AVERAGE | SQ16h_AVERAGE | |
| P11276 | Fibronectin [OS=Mus musculus] | 867.353 | 58 | 95 | 2246 | 59 | 2477 | 272.4 | cell adhesion;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi | signal transduction activity or receptor binding;enzyme regulator activity;other molecular function | 14268 | ENSMUSG00000026193 | Fn1 | G5E8B8; mmu:14268; P11276; Q61567; Q61568; Q61569; Q64233; Q80UI4 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Inflammatory response pathway; Regulation of actin cytoskeleton; Comprehensive IL-17A signaling; Focal adhesion | ECM proteoglycans; Platelet degranulation ; Cell surface interactions at the vascular wall; Syndecan interactions; MAP2K and MAPK activation; Integrin cell surface interactions; Molecules associated with elastic fibres; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Fibronectin matrix formation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; Degradation of the extracellular matrix; Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells; MET activates PTK2 signaling; GPER1 signaling | 0.0844744457809114 | 0.00584906503121538 | 1.50457038391225E-17 | 0.156115961659409 | 0.564710097967506 | 0.435823028559966 | 0.896613838854506 | 2.7641453377804603E7 | 2.022341523870097E8 | 2.12696235413058E8 | 1.2629719382404166E8 | 2.74958241507436E8 | |
| P11087 | Collagen alpha-1(I) chain [OS=Mus musculus] | 797.017 | 79 | 75 | 1933 | 35 | 1453 | 137.9 | cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12842 | ENSMUSG00000001506 | Col1a1 | mmu:12842; P11087; Q53WT0; Q60635; Q61367; Q61427; Q63919; Q6PCL3; Q810J9 | Osteoblast signaling; Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Comprehensive IL-17A signaling; Focal adhesion | Cell surface interactions at the vascular wall; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ECM proteoglycans; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; GPVI-mediated activation cascade; GP1b-IX-V activation signalling; Platelet Adhesion to exposed collagen; Platelet Aggregation (Plug Formation); MET activates PTK2 signaling | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.381922652011049 | 0.0629214061377862 | 0.655833157547641 | 772438.0834537543 | 2.0798706453114033E8 | 5.92854376184685E8 | 5.973622733379293E7 | 8.428319253806247E7 | |
| Q01149 | Collagen alpha-2(I) chain [OS=Mus musculus] | 773.662 | 80 | 66 | 1731 | 51 | 1372 | 129.5 | cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12843 | ENSMUSG00000029661 | Col1a2 | mmu:12843; Q01149; Q8CGA5 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Focal adhesion | Crosslinking of collagen fibrils; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; ECM proteoglycans; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; GPVI-mediated activation cascade; GP1b-IX-V activation signalling; Platelet Adhesion to exposed collagen; Platelet Aggregation (Plug Formation); MET activates PTK2 signaling | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.862063111456553 | 0.0347692006632991 | 0.926292871155025 | 182180.3275564673 | 1.7308392932505235E8 | 3.475967473053053E8 | 4.271481968913147E7 | 9.036410240893161E7 | |
| P08121 | Collagen alpha-1(III) chain [OS=Mus musculus] | 695.631 | 63 | 61 | 1789 | 51 | 1464 | 138.9 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | extracellular matrix;other cell component | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 12825 | ENSMUSG00000026043 | Col3a1 | mmu:12825; P08121; Q61429; Q9CRN7 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Focal adhesion | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ECM proteoglycans; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; MET activates PTK2 signaling | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.0413994480640273 | 0.394949139624895 | 0.976852696203657 | 454748.1180174556 | 6.282890624937943E7 | 2.8394661715058166E8 | 3.0365458724261332E7 | 6.6157215803336866E7 | |
| Q9QXS1 | Plectin [OS=Mus musculus] | 659.702 | 46 | 182 | 1705 | 180 | 4691 | 533.9 | cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component | cytoskeletal activity;other molecular function | 18810 | ENSMUSG00000022565 | Plec | E9QN87; mmu:18810; Q6S384; Q6S389; Q6S394; Q9CS65; Q9QUT2; Q9QXQ8; Q9QXQ9; Q9QXR0; Q9QXR1; Q9QXR2; Q9QXR3; Q9QXR4; Q9QXR5; Q9QXR6; Q9QXR7; Q9QXR8; Q9QXR9; Q9QXS0; Q9QXS1; Q9QXS2; Q9QXS3 | Alpha 6 beta 4 integrin signaling pathway; EGFR1 signaling pathway | Type I hemidesmosome assembly; Caspase-mediated cleavage of cytoskeletal proteins | 0.481729871164266 | 0.714932595871944 | 0.336550483871782 | 0.572524806937582 | 0.532399788858771 | 0.702330308974487 | 0.520376293994664 | 309922.514176982 | 4599273.114185064 | 1.6676006673579365E7 | 1.01501282886872E7 | 4.28490141732006E7 | |
| P08122 | Collagen alpha-2(IV) chain [OS=Mus musculus] | 526.992 | 64 | 69 | 1077 | 69 | 1707 | 167.2 | RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix | extracellular structural activity | 12827 | ENSMUSG00000031503 | Col4a2 | mmu:12827; P08122; Q3B7C2; Q3TPV9; Q61375; Q66JS5; Q6RCT6; Q6RCT7; Q6U9X1; Q8BPI9; Q8BPK3; Q91VI3 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Focal adhesion | Laminin interactions; Signaling by PDGF; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions | 0.352816378116182 | 0.64759425713406 | 0.293387877727491 | 0.79866917976589 | 0.169673447599406 | 0.959159975702413 | 0.483015668880262 | 1393534.8123072747 | 1.3981747232493034E7 | 5.0194805286054574E7 | 1.701609057115766E7 | 5.972856146483746E7 | |
| Q3U962 | Collagen alpha-2(V) chain [OS=Mus musculus] | 518.514 | 64 | 57 | 817 | 55 | 1497 | 144.9 | cell organization and biogenesis;developmental processes;other biological processes | extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12832 | ENSMUSG00000026042 | Col5a2 | mmu:12832; Q3TVR2; Q3U962; Q3UHK7; Q3UTT4; Q3V1J6; Q61431; Q7TMS0; Q80VS8 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions | 0.861384746267066 | 0.961254912149485 | 0.730324052254867 | 0.632833892117728 | 0.273444295895674 | 0.453486790198347 | 0.973358018692255 | 2.4419841082594533E7 | 1.5753424919239333E7 | 4.592471970087584E7 | 1.0471363011153279E7 | 2.1079551940947264E7 | |
| Q05793 | Basement membrane-specific heparan sulfate proteoglycan core protein [OS=Mus musculus] | 507.28 | 33 | 84 | 998 | 84 | 3707 | 398 | cell organization and biogenesis;transport;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;ER/Golgi | other molecular function | 15530 | Hspg2 | mmu:15530; Q05793 | 0.332090710292395 | 0.382764581022518 | 0.771134174410141 | 0.553652046981626 | 0.938381933295379 | 0.285967432697218 | 0.908661395894721 | 171009.25706548532 | 2.1355561683383033E7 | 4.109385814368304E7 | 8244737.341084313 | 1.8998181152407136E7 | ||||
| Q61554 | Fibrillin-1 [OS=Mus musculus] | 499.202 | 38 | 86 | 1117 | 86 | 2873 | 312.1 | cell adhesion;other metabolic processes;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 14118 | ENSMUSG00000027204 | Fbn1 | A2AQ53; mmu:14118; Q60826; Q61554 | Comprehensive IL-17A signaling | Integrin cell surface interactions; Degradation of the extracellular matrix; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; TGF-beta receptor signaling activates SMADs; Molecules associated with elastic fibres | 0.0596853092747711 | 0.0840496117897429 | 0.378389090130589 | 0.84258396038376 | 0.862063111456553 | 0.0455630470425967 | 0.77820123247099 | 81731.837224874 | 2.17735814942991E7 | 5.216417896597137E7 | 5145074.9913376765 | 2.082557122129057E7 | |
| Q8BTM8 | Filamin-A [OS=Mus musculus] | 493.069 | 49 | 91 | 915 | 83 | 2647 | 281 | cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;other molecular function | 192176 | ENSMUSG00000031328 | Flna | B7FAV0; O54934; Q7TQI1; Q8BLK1; Q8BTM8; Q8BTN7; Q8VHX5; Q8VHX8; Q99KQ2 | Mapk signaling pathway; Focal adhesion | Platelet degranulation ; Cell-extracellular matrix interactions; RHO GTPases activate PAKs; GP1b-IX-V activation signalling | 0.0844935092512095 | 0.493514006575528 | 0.170420349138264 | 0.67528135146603 | 0.864215513767001 | 0.904360680536565 | 0.8468455705593 | 218480.8558628913 | 4952287.405198824 | 1.1395384793048913E7 | 4296604.098486893 | 1.4686023116833666E7 | |
| P02463 | Collagen alpha-1(IV) chain [OS=Mus musculus] | 487.707 | 70 | 68 | 828 | 68 | 1669 | 160.6 | cell organization and biogenesis;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix | extracellular structural activity;other molecular function | 12826 | ENSMUSG00000031502 | Col4a1 | mmu:12826; P02463; Q3UHJ4; Q3UJE7; Q3UQV2; Q53X35; Q6GQS7; Q6PHB5; Q99LQ8 | Spinal cord injury; Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Laminin interactions; Signaling by PDGF; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions | 0.604225174343649 | 0.68008321917751 | 0.284160251285083 | 0.936818656936794 | 0.167300285011781 | 0.777395712279767 | 0.224623005929948 | 262271.417553364 | 4620515.057112186 | 2.1463797748519864E7 | 8911949.32392111 | 3.3156314746725336E7 | |
| Q60847 | Collagen alpha-1(XII) chain [OS=Mus musculus] | 480.266 | 40 | 95 | 991 | 95 | 3120 | 340 | cell adhesion;developmental processes | other cell component | 12816 | ENSMUSG00000032332 | Col12a1 | mmu:12816; P70322; Q60847 | Assembly of collagen fibrils and other multimeric structures; Collagen chain trimerization; Collagen degradation | 0.0975092237649803 | 1.8644578313253E-17 | 0.344512840834051 | 0.162753188077458 | 0.101350980560035 | 0.0103905836841461 | 0.266844028199729 | 80180.17821443231 | 5.1736330625803865E7 | 2.9952489655588504E7 | 1.0537780206453351E7 | 1.4629541968462234E7 | |||
| Q8VDD5 | Myosin-9 [OS=Mus musculus] | 418.364 | 45 | 73 | 827 | 60 | 1960 | 226.2 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;stress response;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;other molecular function | 17886 | ENSMUSG00000022443 | Myh9 | mmu:17886; Q3UHT9; Q3UHU4; Q6KAN6; Q811I2; Q8VDD5 | Primary focal segmental glomerulosclerosis (FSGS) | RHO GTPases activate PAKs; Regulation of actin dynamics for phagocytic cup formation | 0.156498497144098 | 0.0382609387499984 | 0.118876667035285 | 0.15125389278925 | 0.916542675526027 | 0.91728043005175 | 0.990873516209569 | 100319.6147091511 | 5176534.940650649 | 8067345.413832072 | 7844465.70271172 | 1.9759662960152034E7 | |
| Cont_P02453 | Collagen alpha-1(I) chain OS=Bos taurus OX=9913 GN=COL1A1 PE=1 SV=3 | 414.689 | 43 | 43 | 1208 | 4 | 1463 | 138.9 | cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | 282187 | ENSBTAG00000013103 | COL1A1 | bta:282187; P02453; Q3MHM2 | Inflammatory response pathway; Osteoblast signaling; Focal adhesion | Fibronectin matrix formation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Collagen degradation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; Collagen chain trimerization; GPVI-mediated activation cascade; Platelet Aggregation (Plug Formation); Platelet Adhesion to exposed collagen; GP1b-IX-V activation signalling | 0.800889767710788 | 0.579410556046386 | 0.58548007712969 | 0.839216523231753 | 0.848119069115724 | 0.108042253370914 | 0.0107964100780951 | 228542.54091026666 | 3262486.7198886867 | 3910059.36528234 | 1102058.9569362423 | 924822.5329095138 | |
| Cont_P02769 | Albumin OS=Bos taurus OX=9913 GN=ALB PE=1 SV=4 | 390.555 | 81 | 57 | 7095 | 54 | 607 | 69.2 | stress response;other biological processes | non-structural extracellular;other cell component | nucleic acid binding activity;other molecular function | 280717 | ALB | A5PJX3; bta:280717; O02787; P02769; P04277; Q3SZR2 | 0.520832629933248 | 0.650544967914241 | 0.598172767155558 | 0.497906326712893 | 0.413798631523592 | 0.846117085258013 | 0.468531677746422 | 2.7142766432154403E9 | 2.9099571807541137E9 | 2.4034772237737E9 | 2.38097622607819E9 | 2.6841204207378564E9 | ||||
| P01027 | Complement C3 [OS=Mus musculus] | 388.541 | 53 | 70 | 1148 | 62 | 1663 | 186.4 | cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular;other cell component | signal transduction activity or receptor binding;enzyme regulator activity | 12266 | ENSMUSG00000024164 | C3 | mmu:12266; P01027; Q61370; Q80XP1 | Complement activation, classical pathway; Tyrobp causal network in microglia; Comprehensive IL-17A signaling | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade; Neutrophil degranulation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; G alpha (i) signalling events; Peptide ligand-binding receptors; Alternative complement activation; Activation of C3 and C5 | 0.712660037675161 | 0.729783028721347 | 0.506101547380209 | 0.762068821001752 | 0.512232143465318 | 0.413470300505934 | 0.991722673088443 | 3269916.660849947 | 1.6657146132333001E7 | 4.4549110086954266E7 | 3.6733221642207734E7 | 8.026680998659676E7 | |
| Cont_Q7SIH1 | Alpha-2-macroglobulin OS=Bos taurus OX=9913 GN=A2M PE=1 SV=2 | 370.864 | 53 | 56 | 1089 | 56 | 1510 | 167.5 | non-structural extracellular | enzyme regulator activity;other molecular function | 513856 | ENSBTAG00000018137 | A2M | A8E647; bta:513856; Q7SIH1 | IL-6 signaling pathway | 0.688450665125024 | 0.839052280267302 | 0.731111241255251 | 0.509007335932165 | 0.540124873725708 | 0.671798309985569 | 0.809503222445875 | 5.423624331449187E7 | 7.564994624258716E7 | 7.018676700369896E7 | 5.23492843648457E7 | 8.250822323914327E7 | |||
| Cont_Q29443 | Serotransferrin OS=Bos taurus OX=9913 GN=TF PE=2 SV=1 | 343.183 | 74 | 48 | 1709 | 46 | 704 | 77.7 | stress response;transport;other biological processes | non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle | other molecular function | 280705 | TF | bta:280705; Q0IIK2; Q29443 | 0.615274986253429 | 0.964709887217926 | 0.600414647182016 | 0.571407162236119 | 0.105569810421019 | 0.506704636011438 | 0.313748671859839 | 1.48932090998098E8 | 2.32106703986673E8 | 1.5606409762411097E8 | 1.3567523181654152E8 | 1.6257112433260167E8 | ||||
| Cont_P07589 | Fibronectin OS=Bos taurus OX=9913 GN=FN1 PE=1 SV=4 | 337.517 | 26 | 47 | 923 | 11 | 2478 | 272 | cell adhesion;cell organization and biogenesis;stress response;developmental processes;other biological processes | non-structural extracellular | signal transduction activity or receptor binding;other molecular function | FN1 | P07589 | 0.714071857030863 | 0.525827426782658 | 0.94971810013306 | 0.802863674292211 | 0.634088329627404 | 0.35834247597224 | 0.281927255363179 | 166255.75410196633 | 835883.8306505851 | 952169.9232567847 | 482619.7682389803 | 602598.7403397557 | |||||
| Q80X90 | Filamin-B [OS=Mus musculus] | 335.882 | 38 | 75 | 608 | 66 | 2602 | 277.7 | cell organization and biogenesis;stress response;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 286940 | ENSMUSG00000025278 | Flnb | E9QNV9; mmu:286940; Q80X90; Q8VHX4; Q8VHX7; Q99KY3 | ISG15 antiviral mechanism | 0.296944306247309 | 0.238365792894698 | 0.254729742039053 | 0.629546282386664 | 0.897564267605108 | 0.872448101434609 | 0.866446545996913 | 154624.23024854946 | 2351112.5534752235 | 6048828.490809467 | 1865154.4144755967 | 7592568.170254476 | ||
| Cont_P35527 | Keratin, type I cytoskeletal 9 OS=Homo sapiens OX=9606 GN=KRT9 PE=1 SV=3 | 310.424 | 69 | 35 | 915 | 34 | 623 | 62 | cell organization and biogenesis;other biological processes | cytosol;cytoskeleton | cytoskeletal activity | 3857 | ENSG00000171403 | KRT9 | hsa:3857; O00109; P35527; Q0IJ47; Q14665 | Formation of the cornified envelope | 0.836660982916281 | 0.73072258897653 | 0.769556732848094 | 0.964570089320365 | 0.936669139837906 | 0.516448827835279 | 0.0110179641295352 | 2.9224080803851068E7 | 3.250630567014273E7 | 4.1318104811136335E7 | 9.369998400542612E7 | 5.1433611479478456E7 | ||
| Cont_P04264 | Keratin, type II cytoskeletal 1 OS=Homo sapiens OX=9606 GN=KRT1 PE=1 SV=6 | 306.58 | 65 | 45 | 1774 | 36 | 644 | 66 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;other molecular function | 3848 | ENSG00000167768 | KRT1 | B2RA01; hsa:3848; P04264; P85925; P86104; Q14720; Q6GSJ0; Q9H298 | Corticotropin-releasing hormone signaling | Formation of the cornified envelope; Neutrophil degranulation; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.65780924735352 | 0.653826967689551 | 0.631165145316661 | 0.89629386854896 | 0.770634810212039 | 0.254077056479593 | 5.78940441291519E-5 | 1.5397854514739665E8 | 1.3414412508194733E8 | 1.6528138436319932E8 | 4.476405570139613E8 | 1.7631437693719265E8 | |
| P06909 | Complement factor H [OS=Mus musculus] | 292.01 | 49 | 41 | 540 | 41 | 1234 | 139 | cell adhesion;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes | non-structural extracellular;plasma membrane;other membranes;mitochondrion;other cell component | other molecular function | 12628 | ENSMUSG00000026365 | Cfh | mmu:12628; P06909; Q6NZK3 | Regulation of Complement cascade | 0.205200089226065 | 0.0359547312524068 | 1.50457038391225E-17 | 0.329485122608543 | 0.532399788858771 | 0.750662231008662 | 0.443116920082088 | 59542.32714759521 | 1.0566840244224759E7 | 1.036081717107911E7 | 8439848.284125684 | 2.9357524779450033E7 | ||
| P16546 | Spectrin alpha chain, non-erythrocytic 1 [OS=Mus musculus] | 291.854 | 35 | 74 | 473 | 74 | 2472 | 284.4 | cell organization and biogenesis | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 20740 | ENSMUSG00000057738 | Sptan1 | A3KGU6; A3KGU8; P16546; Q8K380; Q9CT05 | FAS pathway and stress induction of HSP regulation | Neutrophil degranulation; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Interaction between L1 and Ankyrins; COPI-mediated anterograde transport; RHOU GTPase cycle; RHOV GTPase cycle; Caspase-mediated cleavage of cytoskeletal proteins | 0.958962194559628 | 0.786160319109602 | 0.611910908670005 | 0.890289034593217 | 0.771887919257916 | 0.870511801558508 | 0.852906094467594 | 684626.7741473566 | 1427277.73205798 | 3976922.979229001 | 2263434.85725903 | 8138355.29233573 | |
| Cont_P13645 | Keratin, type I cytoskeletal 10 OS=Homo sapiens OX=9606 GN=KRT10 PE=1 SV=6 | 286.713 | 62 | 30 | 1322 | 20 | 584 | 58.8 | cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes | plasma membrane;cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;other molecular function | 3858 | ENSG00000186395 | KRT10 | hsa:3858; P13645; Q14664; Q8N175 | Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.600890052902075 | 0.490821286240141 | 0.561934876627864 | 0.941696908693733 | 0.880940844456856 | 0.246231694954624 | 2.55433624902191E-5 | 1.1091978559495355E8 | 9.409796786421584E7 | 1.13950700113199E8 | 3.19749190691826E8 | 1.0914077913761683E8 | ||
| Cont_P35908 | Keratin, type II cytoskeletal 2 epidermal OS=Homo sapiens OX=9606 GN=KRT2 PE=1 SV=2 | 284.975 | 78 | 42 | 1022 | 32 | 639 | 65.4 | cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes | plasma membrane;cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;cytoskeletal activity | 3849 | ENSG00000172867 | KRT2 | hsa:3849; P35908; Q4VAQ2 | Formation of the cornified envelope | 0.499413631103761 | 0.411258958244596 | 0.544106843431104 | 0.933570718645937 | 0.862063111456553 | 0.309041843038519 | 2.9837536993241E-4 | 4.776750778997586E7 | 2.9357809740500167E7 | 3.415287514761583E7 | 7.640800383787991E7 | 3.617272663897294E7 | ||
| Q62059 | Versican core protein [OS=Mus musculus] | 279.715 | 17 | 44 | 1073 | 44 | 3357 | 366.6 | cell adhesion;developmental processes | non-structural extracellular;extracellular matrix;other cell component | other molecular function | Vcan | Q62058; Q62059; Q9CUU0 | ECM proteoglycans; Glycosaminoglycan-protein linkage region biosynthesis; CS/DS degradation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; CS-GAG biosynthesis; DS-GAG biosynthesis | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.613304974369123 | 0.478009151463064 | 0.783304059803245 | 104188.56292801573 | 9.037034497028168E7 | 9.467651077277745E7 | 5.89459061512507E7 | 9.510262638582683E7 | ||||
| P10493 | Nidogen-1 [OS=Mus musculus] | 275.191 | 43 | 42 | 852 | 42 | 1245 | 136.5 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | other molecular function | 18073 | ENSMUSG00000005397 | Nid1 | mmu:18073; P10493; Q3TKX9; Q8BQI3; Q8C3U8; Q8C9P6 | Laminin interactions; Degradation of the extracellular matrix | 1.65082956259427E-17 | 1.8644578313253E-17 | 0.251140212279038 | 0.461941385639594 | 0.604382524464811 | 1.0740690550749E-5 | 0.781368126060588 | 322455.2944414853 | 1.2120394496125467E8 | 1.2671518083095133E8 | 9146738.193898173 | 3.1971627034095198E7 | ||
| O88207 | Collagen alpha-1(V) chain [OS=Mus musculus] | 275.025 | 46 | 52 | 413 | 44 | 1838 | 183.6 | cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes | extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12831 | ENSMUSG00000026837 | Col5a1 | A3KGE3; mmu:12831; O88207; Q3UG94; Q6F6B0 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | ECM proteoglycans; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; MET activates PTK2 signaling | 1.65082956259427E-17 | 1.8644578313253E-17 | 0.268653947705267 | 0.311207075116757 | 0.848119069115724 | 0.302671730722046 | 0.809503222445875 | 80388.83753211687 | 3577832.3612721 | 8562033.320911517 | 1386447.3981625708 | 3098568.0509616495 | |
| P37889 | Fibulin-2 [OS=Mus musculus] | 269.894 | 43 | 37 | 791 | 37 | 1221 | 131.7 | other biological processes | non-structural extracellular | other molecular function | 14115 | ENSMUSG00000064080 | Fbln2 | G5E8B3; mmu:14115; P37889; Q9WUI2 | Molecules associated with elastic fibres | 1.65082956259427E-17 | 0.0640195441309023 | 0.201227492083465 | 0.255240026777032 | 0.803447472095846 | 0.290132264062119 | 0.809503222445875 | 362692.0010392267 | 6.556805587417743E7 | 8.021475911820169E7 | 3.00676966042863E7 | 4.93487108032657E7 | ||
| Q8VHX6 | Filamin-C [OS=Mus musculus] | 249.498 | 31 | 65 | 425 | 56 | 2726 | 290.9 | cell organization and biogenesis;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity | 68794 | ENSMUSG00000068699 | Flnc | B2RY80; B9EKT2; mmu:68794; Q6PAI6; Q8VHX6; Q9JJ38 | Cell-extracellular matrix interactions | 0.562594032195739 | 0.719627996749639 | 0.962331548063155 | 0.57290809187594 | 0.96786708205164 | 0.933437821008547 | 0.80954066750699 | 406087.97266412666 | 1016453.1391661359 | 2089599.8263247435 | 1136666.5742976035 | 4459384.47065665 | ||
| Q04857 | Collagen alpha-1(VI) chain [OS=Mus musculus] | 248.981 | 44 | 33 | 588 | 33 | 1025 | 108.4 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component | other molecular function | 12833 | ENSMUSG00000001119 | Col6a1 | mmu:12833; Q04857 | ECM proteoglycans; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Signaling by PDGF; NCAM1 interactions | 0.2534363617947 | 0.392208211277376 | 0.962331548063155 | 0.971216996811237 | 0.97504218639442 | 0.115965329440656 | 0.380888676065133 | 76865.2077476112 | 5.0068940213435836E7 | 6.914260176814564E7 | 1.4473176745930666E7 | 1.9886194591010433E7 | ||
| Cont_Q2UVX4 | Complement C3 OS=Bos taurus OX=9913 GN=C3 PE=1 SV=2 | 247.154 | 39 | 55 | 851 | 47 | 1661 | 187.1 | cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular;other cell component | signal transduction activity or receptor binding;enzyme regulator activity | 280677 | ENSBTAG00000017280 | C3 | bta:280677; Q2KIZ4; Q2UVX4 | Complement and coagulation cascades; Complement activation, classical pathway | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Neutrophil degranulation; Peptide ligand-binding receptors; G alpha (i) signalling events; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade; Alternative complement activation; Activation of C3 and C5 | 0.615680953989958 | 0.798729234704005 | 0.573945385766997 | 0.506364847510615 | 0.291700662163587 | 0.591028379533681 | 0.448532796991499 | 1.4686759191254234E7 | 1.84550126489547E7 | 1.5291804049274266E7 | 1.196234797265725E7 | 1.6127794015790733E7 | |
| Q62261 | Spectrin beta chain, non-erythrocytic 1 [OS=Mus musculus] | 244.684 | 30 | 61 | 398 | 61 | 2363 | 274.1 | cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 20742 | ENSMUSG00000020315 | Sptbn1 | A2AFU1; mmu:20742; Q3TEM7; Q5SQL8; Q5SQL9; Q62261; Q9QWJ7 | COPI-mediated anterograde transport; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; RHOU GTPase cycle; Interaction between L1 and Ankyrins; RHOV GTPase cycle | 0.69394578118832 | 0.776437620310661 | 0.693719649766064 | 0.831411077141515 | 0.86315143463057 | 0.664971370235365 | 0.953305976192702 | 492454.03878621367 | 920886.7046363313 | 2921004.358024217 | 2299979.2063157237 | 6417771.720584608 | ||
| Q640N1 | Adipocyte enhancer-binding protein 1 [OS=Mus musculus] | 239.707 | 38 | 34 | 648 | 34 | 1128 | 128.3 | protein metabolism;other biological processes | nucleus;other cell component | nucleic acid binding activity;other molecular function | 11568 | ENSMUSG00000020473 | Aebp1 | mmu:11568; O88442; Q3TVV5; Q3TWA7; Q3TX56; Q3TXB2; Q5NCI9; Q61281; Q640N1 | 0.269326617826563 | 0.0457359864845759 | 0.605387748357992 | 0.631359014803774 | 0.760992448481534 | 0.145805028390539 | 0.963436677882021 | 4843934.666021533 | 3.9556778473622136E7 | 4.1143769603117764E7 | 1.8648394999714002E7 | 3.1901344171106894E7 | |||
| P57780 | Alpha-actinin-4 [OS=Mus musculus] | 239.42 | 58 | 45 | 483 | 30 | 912 | 104.9 | cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes | cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 60595 | ENSMUSG00000054808 | Actn4 | mmu:60595; P57780 | Primary focal segmental glomerulosclerosis (FSGS) | Platelet degranulation | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 0.19149089837131 | 0.795351011232032 | 0.968364585136618 | 0.938282411159324 | 20900.169415734228 | 4580996.01302682 | 9830280.285985528 | 4440337.50144963 | 1.1658414413951913E7 | |
| Q7TPR4 | Alpha-actinin-1 [OS=Mus musculus] | 235.529 | 54 | 42 | 511 | 27 | 892 | 103 | cell adhesion;cell organization and biogenesis;other biological processes | plasma membrane;other membranes;cytoskeleton;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function | 109711 | ENSMUSG00000015143 | Actn1 | mmu:109711; Q7TPR4 | Regulation of actin cytoskeleton; Integrin-mediated cell adhesion; Focal adhesion | Platelet degranulation ; RHOF GTPase cycle; RHOBTB2 GTPase cycle; RHOD GTPase cycle; Regulation of cytoskeletal remodeling and cell spreading by IPP complex components | 0.995554138371554 | 0.178726136005694 | 0.819280225722906 | 0.941696908693733 | 0.744084716394381 | 0.837231569641376 | 0.879972045955715 | 486802.1989182571 | 2525588.7379033365 | 6210475.170240924 | 3717490.65968503 | 9946958.94260729 | |
| P02468 | Laminin subunit gamma-1 [OS=Mus musculus] | 230.882 | 35 | 43 | 454 | 43 | 1607 | 177.2 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | Lamc1 | P02468 | 0.118212047511996 | 0.116315527815218 | 0.459134305737471 | 0.675951294045723 | 0.877818946381645 | 0.368062651583427 | 0.922276466908065 | 18104.5719498812 | 7327169.184632126 | 1.61740059690847E7 | 3246292.9185144133 | 7951596.802164167 | |||||
| Q91ZX7 | Prolow-density lipoprotein receptor-related protein 1 [OS=Mus musculus] | 230.497 | 15 | 57 | 519 | 56 | 4545 | 504.4 | other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;other molecular function | 16971 | Lrp1 | mmu:16971; Q61291; Q91ZX7; Q920Y4 | Statin pathway; Wnt signaling pathway | Scavenging of heme from plasma; Retinoid metabolism and transport | 1.65082956259427E-17 | 0.0181625429641231 | 0.133639440745791 | 0.150830220548111 | 0.925871264502428 | 0.74148782464906 | 0.901098484497789 | 30670.78727387535 | 3548407.5296101067 | 7355877.025944923 | 2243610.9879279765 | 5724840.5342227295 | ||
| Cont_P60712 | Actin, cytoplasmic 1 OS=Bos taurus OX=9913 GN=ACTB PE=1 SV=1 | 225.45 | 70 | 19 | 852 | 2 | 375 | 41.7 | cell organization and biogenesis;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component | enzyme regulator activity;cytoskeletal activity;other molecular function | 100033878; 100135470; 100173832; 101844587; 102139853; 11461; 118833809; 280979; 396526; 403580; 414396; 443052; 450133; 60; 81822 | ENSBTAG00000026199; ENSCAFG00000016020; ENSCAFG00030015381; ENSCAFG00040015695; ENSCPOG00000013467; ENSG00000075624; ENSMAUG00000008763; ENSMUSG00000029580; ENSOARG00040012985; ENSOARG00180022443; ENSOARG00185023855; ENSOARG00215030140; ENSOARG00225009314; ENSPPYG00000017336; ENSPTRG00000018890; ENSRNOG00000034254; ENSSSCG00000007585; ENSSSCG00030003451; ENSSSCG00035038792; ENSSSCG00040049462; ENSSSCG00045027458; ENSSSCG00050065025; ENSSSCG00055012597; ENSSSCG00060019124; ENSSSCG00065037921; ENSSSCG00070011353; ENSSSCG00105030144; ENSSSCG00110026965; ENSSSCG00115013637; ENSSSCG00130033784 | Actb; ACTB | A5D961; A5PKA1; bta:280979; cfa:403580; cpoc:100135470; csab:103246953; ecb:100033878; gga:396526; hsa:60; maua:101844587; mmu:11461; O18840; oas:443052; P02570; P60706; P60707; P60708; P60709; P60710; P60711; P60712; P60713; P70514; P99021; pon:100173832; ptr:450133; Q11209; Q11211; Q3SZD2; Q3TI89; Q3TVP6; Q4L0Y2; Q4R561; Q5R1X3; Q5R582; Q5R6G0; Q64316; Q6QAQ1; Q6ZWM3; Q711N9; Q71FK5; Q75MN2; Q76N69; Q8MIJ0; Q8SPX4; Q95164; Q96B34; Q96HG5; rno:81822; ssc:414396 | FAS pathway and stress induction of HSP regulation; Actin cytoskeleton regulation; Myometrial relaxation and contraction pathways; Focal adhesion; Arrhythmogenic right ventricular cardiomyopathy; Pathogenic Escherichia coli infection; Common pathways underlying drug addiction; Myometrial relaxation and contraction pathways; Focal adhesion; Fas ligand pathway and stress induction of heat shock proteins; Pathogenic Escherichia coli infection; Arrhythmogenic right ventricular cardiomyopathy; Focal adhesion; Myometrial relaxation and contraction pathways; Regulation of actin cytoskeleton; Myometrial relaxation and contraction pathways; Ebola virus infection in host; Acute viral myocarditis; Thermogenesis; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Overlap between signal transduction pathways contributing to LMNA laminopathies; Pleural mesothelioma; Regulation of actin cytoskeleton; Network map of SARS-CoV-2 signaling; Regulation of actin cytoskeleton; Regulation of actin cytoskeleton; Focal adhesion | Formation of the canonical BAF (cBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); Regulation of actin dynamics for phagocytic cup formation; EPH-ephrin mediated repulsion of cells; Formation of annular gap junctions; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; RHO GTPases Activate Formins; RHOF GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; B-WICH complex positively regulates rRNA expression; Regulation of CDH1 Function; Formation of the dystrophin-glycoprotein complex (DGC); Formation of the canonical BAF (cBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); RHO GTPases Activate WASPs and WAVEs; UCH proteinases; DNA Damage Recognition in GG-NER; Formation of the non-canonical BAF (ncBAF) complex; RHO GTPases activate IQGAPs; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Cell-extracellular matrix interactions; MAP2K and MAPK activation; Interaction between L1 and Ankyrins; RHOF GTPase cycle; DNA Damage Recognition in GG-NER; MAP2K and MAPK activation; RHO GTPases Activate Formins; Clathrin-mediated endocytosis; UCH proteinases; RHOF GTPase cycle; DNA Damage Recognition in GG-NER; EPH-ephrin mediated repulsion of cells; VEGFA-VEGFR2 Pathway; Regulation of actin dynamics for phagocytic cup formation; Adherens junctions interactions; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); RHO GTPases Activate WASPs and WAVEs; B-WICH complex positively regulates rRNA expression; Regulation of CDH1 Function; EPHB-mediated forward signaling; Formation of the non-canonical BAF (ncBAF) complex; Formation of the canonical BAF (cBAF) complex; Formation of annular gap junctions; RHO GTPases activate IQGAPs; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; RHO GTPases Activate WASPs and WAVEs; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RHO GTPases activate IQGAPs; RHO GTPases Activate Formins; RHOF GTPase cycle; Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs); B-WICH complex positively regulates rRNA expression; Signaling by BRAF and RAF1 fusions; UCH proteinases; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; VEGFA-VEGFR2 Pathway; Formation of the dystrophin-glycoprotein complex (DGC); Factors involved in megakaryocyte development and platelet production; Regulation of MITF-M-dependent genes involved in pigmentation; Formation of the canonical BAF (cBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); EPH-ephrin mediated repulsion of cells; HATs acetylate histones; Interaction between L1 and Ankyrins; Prefoldin mediated transfer of substrate to CCT/TriC; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Adherens junctions interactions; Regulation of CDH1 Function; Formation of the non-canonical BAF (ncBAF) complex; DNA Damage Recognition in GG-NER; Formation of the polybromo-BAF (pBAF) complex; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Formation of annular gap junctions; Folding of actin by CCT/TriC; Cell-extracellular matrix interactions; MAP2K and MAPK activation; RHO GTPases Activate Formins; Recycling pathway of L1; RHO GTPases activate IQGAPs; Clathrin-mediated endocytosis; Formation of the dystrophin-glycoprotein complex (DGC); EPHB-mediated forward signaling; UCH proteinases; B-WICH complex positively regulates rRNA expression; Adherens junctions interactions; Formation of the non-canonical BAF (ncBAF) complex; Formation of annular gap junctions; Formation of the polybromo-BAF (pBAF) complex; VEGFA-VEGFR2 Pathway; Cell-extracellular matrix interactions; RHO GTPases Activate WASPs and WAVEs; Regulation of CDH1 Function; Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; UCH proteinases; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); Formation of the polybromo-BAF (pBAF) complex; B-WICH complex positively regulates rRNA expression; DNA Damage Recognition in GG-NER; Formation of the canonical BAF (cBAF) complex; RHO GTPases Activate Formins; Regulation of CDH1 Function; Interaction between L1 and Ankyrins; RHOF GTPase cycle; Formation of the non-canonical BAF (ncBAF) complex; Adherens junctions interactions; Formation of the dystrophin-glycoprotein complex (DGC); VEGFA-VEGFR2 Pathway; RHO GTPases Activate WASPs and WAVEs; Cell-extracellular matrix interactions; EPHB-mediated forward signaling; MAP2K and MAPK activation; Recycling pathway of L1; RHO GTPases activate IQGAPs; Formation of annular gap junctions; B-WICH complex positively regulates rRNA expression; UCH proteinases; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); MAP2K and MAPK activation; Formation of the polybromo-BAF (pBAF) complex; RHO GTPases Activate Formins; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases Activate WASPs and WAVEs; Formation of the dystrophin-glycoprotein complex (DGC); VEGFA-VEGFR2 Pathway; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; DNA Damage Recognition in GG-NER; RHOF GTPase cycle; Cell-extracellular matrix interactions; Adherens junctions interactions; Formation of the non-canonical BAF (ncBAF) complex; Formation of the canonical BAF (cBAF) complex; RHO GTPases activate IQGAPs; Regulation of CDH1 Function; Gap junction degradation; Formation of annular gap junctions; Regulation of actin dynamics for phagocytic cup formation; RHOF GTPase cycle; Clathrin-mediated endocytosis; RHO GTPases Activate Formins; Cell-extracellular matrix interactions; VEGFA-VEGFR2 Pathway; Adherens junctions interactions; RHO GTPases activate IQGAPs; UCH proteinases; EPHB-mediated forward signaling; MAP2K and MAPK activation; RHO GTPases Activate WASPs and WAVEs; Formation of the dystrophin-glycoprotein complex (DGC); Formation of annular gap junctions; Formation of the canonical BAF (cBAF) complex; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of the non-canonical BAF (ncBAF) complex; Regulation of CDH1 Function | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.994348552930242 | 0.963278515868644 | 0.938282411159324 | 1996659.4544256767 | 4.828873920581084E7 | 6.5074451419171505E7 | 5.335770948168167E7 | 1.0984219759318356E8 | |
| P63260 | Actin, cytoplasmic 2 [OS=Mus musculus] | 217.791 | 70 | 19 | 831 | 2 | 375 | 41.8 | cell organization and biogenesis;stress response;developmental processes;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 11465 | ENSMUSG00000062825 | Actg1 | mmu:11465; P02571; P14104; P63260; P99022 | Myometrial relaxation and contraction pathways; Regulation of actin cytoskeleton; Focal adhesion | Platelet degranulation ; RHO GTPases activate IQGAPs; Adherens junctions interactions; Regulation of CDH1 Function; RHO GTPases Activate Formins; Regulation of actin dynamics for phagocytic cup formation; Interaction between L1 and Ankyrins; MAP2K and MAPK activation; Recycling pathway of L1; Clathrin-mediated endocytosis; Formation of the dystrophin-glycoprotein complex (DGC); EPHB-mediated forward signaling; RHOF GTPase cycle; Formation of annular gap junctions; VEGFA-VEGFR2 Pathway; Cell-extracellular matrix interactions; RHO GTPases Activate WASPs and WAVEs; RHOBTB2 GTPase cycle | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.901789796153066 | 0.731487178650893 | 0.819844267712751 | 145698.54484736864 | 254666.434448248 | 126248.83655432604 | 256671.2110968777 | ||
| P33434 | 72 kDa type IV collagenase [OS=Mus musculus] | 212.03 | 56 | 30 | 889 | 30 | 662 | 74.1 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes | extracellular matrix;plasma membrane;other membranes;cytoskeleton;mitochondrion;nucleus;other cell component | other molecular function | 17390 | ENSMUSG00000031740 | Mmp2 | mmu:17390; P33434 | Lung fibrosis; IL-3 signaling pathway; Matrix metalloproteinases | Collagen degradation; Extra-nuclear estrogen signaling; EPH-ephrin mediated repulsion of cells; Activation of Matrix Metalloproteinases | 0.372996577396536 | 0.964209443670126 | 0.342075680986172 | 0.708142491896103 | 0.459747209584207 | 0.34519376377552 | 0.809503222445875 | 2.5908623508144036E7 | 2.11513119484971E7 | 6.116415043649567E7 | 5.359802560613743E7 | 8.73371018908004E7 | |
| P19096 | Fatty acid synthase [OS=Mus musculus] | 203.372 | 23 | 48 | 335 | 48 | 2504 | 272.3 | other metabolic processes;stress response;other biological processes | plasma membrane;other membranes;cytosol;ER/Golgi;other cell component | other molecular function | 14104 | ENSMUSG00000025153 | Fasn | B1ATU8; mmu:14104; P19096; Q6PB72; Q8C4Z0; Q9EQR0 | Fatty acid biosynthesis; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-9 fatty acid synthesis; Elongation of (very) long chain fatty acids | Fatty acyl-CoA biosynthesis; Vitamin B5 (pantothenate) metabolism | 0.66189768147619 | 0.847457711018997 | 0.951921622352553 | 0.605074788683686 | 0.994834213681465 | 0.746782404466558 | 0.990873516209569 | 102793.32580216101 | 1389784.0897720233 | 2729524.669883373 | 892753.3234074336 | 2995475.6339221266 | |
| Cont_Q3SZ57 | Alpha-fetoprotein OS=Bos taurus OX=9913 GN=AFP PE=2 SV=1 | 202.89 | 62 | 30 | 1153 | 29 | 610 | 68.5 | other metabolic processes;developmental processes;other biological processes | non-structural extracellular;other cell component | other molecular function | 506011 | ENSBTAG00000017131 | AFP | bta:506011; Q3SZ57 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 0.540832988168188 | 0.82964085881652 | 0.605387748357992 | 0.553772240900005 | 0.15729598575093 | 0.699570390946254 | 0.323545662226049 | 3.8603879197485335E7 | 4.5317948160280704E7 | 3.6151020512819335E7 | 3.679174310656657E7 | 4.2915740009991035E7 | ||
| P48678 | Prelamin-A/C [OS=Mus musculus] | 202.607 | 60 | 37 | 529 | 36 | 665 | 74.2 | cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes | other membranes;cytoskeleton;nucleus;other cell component | other molecular function | 16905 | ENSMUSG00000028063 | Lmna | B3RH23; B3RH24; mmu:16905; P11516; P48678; P97859; Q3TIH0; Q3TTS8; Q3U733; Q3U7I5; Q3UCA0; Q3UCJ8; Q3UCU3; Q91WF2; Q9DC21 | Adipogenesis genes; FAS pathway and stress induction of HSP regulation | 1.65082956259427E-17 | 0.00670345592293191 | 0.139423967594304 | 1.70336894001643E-17 | 0.77212820363828 | 0.901149690306505 | 0.00692305873191716 | 75722.11050192213 | 4134986.871037207 | 1.1058985470826533E7 | 6289356.16248022 | 5.369543399964929E7 | ||
| Q02788 | Collagen alpha-2(VI) chain [OS=Mus musculus] | 202.37 | 41 | 36 | 585 | 36 | 1034 | 110.3 | cell adhesion;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component | other molecular function | 12834 | ENSMUSG00000020241 | Col6a2 | mmu:12834; Q02788; Q05505; Q8C972; Q8K229 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | ECM proteoglycans; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation | 0.175734701097799 | 1.8644578313253E-17 | 0.633123216104285 | 0.767312384697355 | 0.880899056945259 | 0.0961283818482991 | 0.809503222445875 | 121237.29953889274 | 4.136492509189963E7 | 5.21291258166705E7 | 1.173163988850227E7 | 2.0595787144729633E7 | |
| P97927 | Laminin subunit alpha-4 [OS=Mus musculus] | 199.33 | 30 | 41 | 409 | 41 | 1816 | 201.7 | cell adhesion;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | signal transduction activity or receptor binding | 16775 | ENSMUSG00000019846 | Lama4 | mmu:16775; O88785; P70409; P97927; Q14BF2 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Formation of the dystrophin-glycoprotein complex (DGC); Laminin interactions; MET activates PTK2 signaling | 0.496649188935323 | 0.645007535999596 | 0.952104483873957 | 0.825047045401531 | 0.929291541980042 | 0.50594120050135 | 0.819844267712751 | 390078.69973194966 | 5125646.74812024 | 1.037511250312096E7 | 3065544.409694903 | 5760601.1965567535 | |
| P20152 | Vimentin [OS=Mus musculus] | 183.446 | 60 | 29 | 762 | 27 | 466 | 53.7 | cell organization and biogenesis;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component | cytoskeletal activity;nucleic acid binding activity;other molecular function | 22352 | ENSMUSG00000026728 | Vim | mmu:22352; O08704; P20152; Q8CCH1 | Spinal cord injury; Primary focal segmental glomerulosclerosis (FSGS); Alpha 6 beta 4 integrin signaling pathway | Aggrephagy; Striated Muscle Contraction; Caspase-mediated cleavage of cytoskeletal proteins; RHOBTB1 GTPase cycle | 1.65082956259427E-17 | 0.0955146622024883 | 1.50457038391225E-17 | 0.137621774180062 | 0.0297998664849654 | 0.840672080806375 | 0.0332723373064956 | 1112472.104030337 | 7365249.698992513 | 3.3401280645601466E7 | 1.292797841903164E7 | 7.464184195594883E7 | |
| Q64727 | Vinculin [OS=Mus musculus] | 182.753 | 50 | 45 | 419 | 45 | 1066 | 116.6 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | plasma membrane;other membranes;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 22330 | ENSMUSG00000021823 | Vcl | mmu:22330; Q64727; Q8BP32; Q8BS46; Q922C5; Q922D9 | Primary focal segmental glomerulosclerosis (FSGS); IL-3 signaling pathway; Regulation of actin cytoskeleton; Integrin-mediated cell adhesion; Focal adhesion | Neutrophil degranulation; High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells; Platelet degranulation ; MAP2K and MAPK activation; Smooth Muscle Contraction; Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells; Regulation of CDH1 Function | 0.208404050858596 | 0.190838415616571 | 0.238791978742132 | 0.504745711776551 | 0.878264980963866 | 0.977491813528386 | 0.958518237573655 | 126150.06188907423 | 1953982.7579073233 | 4840837.086136207 | 2359150.5810886133 | 6758257.200309387 | |
| Q8K4G1 | Latent-transforming growth factor beta-binding protein 4 [OS=Mus musculus] | 180.216 | 27 | 29 | 318 | 29 | 1666 | 178.5 | cell-cell signaling;cell organization and biogenesis;transport;signal transduction | non-structural extracellular;extracellular matrix | other molecular function | 108075 | ENSMUSG00000040488 | Ltbp4 | E9QPD9; mmu:108075; Q8K4G0; Q8K4G1 | TGF-beta receptor signaling activates SMADs; Molecules associated with elastic fibres | 0.308350896322176 | 0.362779483059131 | 1.50457038391225E-17 | 0.170566190602959 | 0.958956615096849 | 0.703189639676216 | 0.915193515309545 | 50068.58855747415 | 1469976.6770863 | 2473680.681365607 | 2657641.7444799202 | 7291299.088613093 | ||
| Q68FD5 | Clathrin heavy chain 1 [OS=Mus musculus] | 180.117 | 32 | 43 | 363 | 43 | 1675 | 191.4 | cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes | plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component | nucleic acid binding activity;other molecular function | 67300 | ENSMUSG00000047126 | Cltc | mmu:67300; Q68FD5 | IL-7 signaling pathway; Kit receptor signaling pathway | MHC class II antigen presentation; Recycling pathway of L1; Cargo recognition for clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis; LDL clearance; Retrograde neurotrophin signalling; Formation of annular gap junctions; Lysosome Vesicle Biogenesis; WNT5A-dependent internalization of FZD4; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation; RHOU GTPase cycle; RHOV GTPase cycle | 0.4248536990637 | 0.198232028950426 | 1.50457038391225E-17 | 0.413413145615294 | 0.840666598828607 | 0.946476383814868 | 0.835383236382767 | 14581.209031729499 | 1426606.2225329466 | 2101059.0869428 | 2078296.563295177 | 6830362.818457293 | |
| P02469 | Laminin subunit beta-1 [OS=Mus musculus] | 179.863 | 27 | 40 | 429 | 39 | 1786 | 197 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;nucleus;other cell component | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 16777 | ENSMUSG00000002900 | Lamb1 | E9PXZ9; P02469 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Inflammatory response pathway; Alpha 6 beta 4 integrin signaling pathway; Focal adhesion | 0.205801242418232 | 0.341417478664423 | 0.526489846375643 | 0.891178501081124 | 0.900334730044572 | 0.356773085915651 | 0.98779298590131 | 1.0460538665187027E7 | 1.4326337702720901E7 | 1.8407714250900764E7 | 2.1078383512013834E7 | 1.149610392953332E7 | ||
| Q01853 | Transitional endoplasmic reticulum ATPase [OS=Mus musculus] | 179.055 | 52 | 32 | 411 | 32 | 806 | 89.3 | cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;other biological processes | other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;enzyme regulator activity;other molecular function | 269523 | ENSMUSG00000028452 | Vcp | mmu:269523; Q01853; Q3TFH9; Q3TIM2; Q3TXN9; Q6PI18; Q8BSR6; Q8CEG4 | IL-9 signaling pathway | RHOH GTPase cycle; Neutrophil degranulation; Protein methylation; Ovarian tumor domain proteases; Neddylation; ABC-family proteins mediated transport; Translesion Synthesis by POLH; Hedgehog ligand biogenesis; KEAP1-NFE2L2 pathway; HSF1 activation; N-glycan trimming in the ER and Calnexin/Calreticulin cycle; Josephin domain DUBs | 0.915230778358139 | 0.645007535999596 | 0.808626104853287 | 0.953867932777128 | 0.877818946381645 | 0.901149690306505 | 0.737824045087029 | 621808.5300221853 | 5338414.413398174 | 9329554.935730066 | 4463650.11042755 | 1.2770955118061693E7 | |
| Q03350 | Thrombospondin-2 [OS=Mus musculus] | 178.303 | 35 | 30 | 328 | 29 | 1172 | 129.8 | cell adhesion;other biological processes | non-structural extracellular;extracellular matrix;other cell component | other molecular function | 21826 | ENSMUSG00000023885 | Thbs2 | mmu:21826; Q03350; Q8CG21 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Signaling by PDGF; O-glycosylation of TSR domain-containing proteins | 0.425958502904743 | 0.861805134687803 | 0.49027994509233 | 0.535702081245677 | 0.900334730044572 | 0.620448351319483 | 0.80954066750699 | 1929828.2171104867 | 7439397.130180354 | 1.1102887711296873E7 | 4211942.301314384 | 1.05864549049655E7 | |
| Q80YX1 | Tenascin [OS=Mus musculus] | 175.9 | 28 | 43 | 191 | 43 | 2110 | 231.7 | cell adhesion;cell-cell signaling;cell organization and biogenesis;stress response;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | signal transduction activity or receptor binding;other molecular function | 21923 | ENSMUSG00000028364 | Tnc | mmu:21923; Q64706; Q80YX1; Q80YX2 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Integrin cell surface interactions; ECM proteoglycans; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 0.117980756369098 | 0.827773046590747 | 0.560799429150649 | 0.474732236495646 | 0.00280630917527262 | 0.00972980877962454 | 0.46732263590517 | 20862.416559578665 | 1449614.4281484466 | 1.2106484504902953E7 | 96243.5238250637 | 211010.04547923067 | |
| Q61147 | Ceruloplasmin [OS=Mus musculus] | 175.43 | 36 | 33 | 380 | 33 | 1061 | 121.1 | cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular | other molecular function | 12870 | ENSMUSG00000003617 | Cp | mmu:12870; Q61147; Q6P5C8 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Iron uptake and transport; Metal ion SLC transporters | 1.65082956259427E-17 | 0.0286042496128814 | 0.232756100865398 | 0.470567140616547 | 0.902824569867946 | 0.217345018530886 | 0.830251457557488 | 116072.0240394514 | 4703216.257241024 | 9598922.193485493 | 1756646.5467629798 | 3587720.1567995367 | ||
| Q3UQ28 | Peroxidasin homolog [OS=Mus musculus] | 173.636 | 35 | 39 | 366 | 39 | 1475 | 165 | cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes | extracellular matrix;ER/Golgi;other cell component | extracellular structural activity;other molecular function | 69675 | ENSMUSG00000020674 | Pxdn | A4FU83; E9QNQ9; mmu:69675; Q3UQ28 | Crosslinking of collagen fibrils | 0.121749369203589 | 0.199060935853007 | 0.481687712882875 | 0.64860195920101 | 0.680311384167738 | 0.622521206052951 | 0.910753558746772 | 52188.79804577449 | 3468268.863888983 | 1.0141728842991263E7 | 1748064.7562207088 | 5865453.59009746 | ||
| Q61316 | Heat shock 70 kDa protein 4 [OS=Mus musculus] | 169.044 | 48 | 31 | 300 | 31 | 841 | 94.1 | protein metabolism;other metabolic processes | other cell component | other molecular function | Hspa4 | Q61316 | Regulation of HSF1-mediated heat shock response | 0.675982462193546 | 0.947627746595709 | 0.704651587991194 | 0.760498481134506 | 0.922660568001848 | 0.905946265571965 | 0.842404289073844 | 51496.56273693644 | 1715523.4149199834 | 3885769.0116153997 | 1450318.0074060035 | 4790126.20554149 | ||||
| Cont_P02533 | Keratin, type I cytoskeletal 14 OS=Homo sapiens OX=9606 GN=KRT14 PE=1 SV=4 | 164.831 | 58 | 26 | 684 | 9 | 472 | 51.5 | cell organization and biogenesis;other biological processes | plasma membrane;cytosol;cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 3861 | ENSG00000186847 | KRT14 | hsa:3861; P02533; Q14715; Q53XY3; Q9BUE3; Q9UBN2; Q9UBN3; Q9UCY4 | Corticotropin-releasing hormone signaling | Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin; Developmental Lineage of Mammary Gland Myoepithelial Cells; Type I hemidesmosome assembly | 0.821333803243143 | 0.880930298968675 | 0.666244110962191 | 0.887279041944908 | 0.728871118050286 | 0.645534074006669 | 1.76226512549596E-4 | 6829492.454091667 | 1.0299655985485494E7 | 9892865.41378706 | 2.9333304518974166E7 | 9460012.597296894 | |
| P11499 | Heat shock protein HSP 90-beta [OS=Mus musculus] | 164.719 | 50 | 29 | 532 | 19 | 724 | 83.2 | cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component | enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function | 15516 | ENSMUSG00000023944 | Hsp90ab1 | mmu:15516; O89078; P11499; Q3UIQ7 | Focal adhesion: PI3K-Akt-mTOR signaling pathway | Neutrophil degranulation; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of actin dynamics for phagocytic cup formation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Attenuation phase; Estrogen-dependent gene expression; Sema3A PAK dependent Axon repulsion; Aryl hydrocarbon receptor signalling; DDX58/IFIH1-mediated induction of interferon-alpha/beta; HSF1 activation; RHOBTB2 GTPase cycle; The NLRP3 inflammasome | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.385192173946943 | 0.975071223710592 | 0.476079393565723 | 166033.98771248801 | 1.0807613687705928E7 | 3.193268303009924E7 | 1.1608041082716169E7 | 4.22825068683512E7 | |
| Q9JKF1 | Ras GTPase-activating-like protein IQGAP1 [OS=Mus musculus] | 163.926 | 28 | 36 | 250 | 36 | 1657 | 188.6 | cell organization and biogenesis;developmental processes;signal transduction;other biological processes | plasma membrane;other membranes;cytoskeleton;nucleus;other cell component | enzyme regulator activity;other molecular function | 29875 | ENSMUSG00000030536 | Iqgap1 | G3UW45; mmu:29875; Q9JKF1 | G13 signaling pathway; Regulation of actin cytoskeleton | RHO GTPases activate IQGAPs; Neutrophil degranulation; RAC1 GTPase cycle; RAC2 GTPase cycle; RHOA GTPase cycle; MAP2K and MAPK activation; RHOQ GTPase cycle; RHOC GTPase cycle; RHOU GTPase cycle; RHOV GTPase cycle; Nephrin family interactions | 0.930229675308081 | 0.794460986683881 | 0.787568130909409 | 0.991639536226218 | 0.941920360687835 | 0.777195460870953 | 0.924682711624237 | 58984.367745696 | 331165.4406654323 | 1068898.0084058929 | 944145.2185002686 | 3795509.9873349466 | |
| P52480 | Pyruvate kinase PKM [OS=Mus musculus] | 163.393 | 62 | 27 | 442 | 27 | 531 | 57.8 | cell organization and biogenesis;other metabolic processes;other biological processes | cytosol;ER/Golgi;nucleus;other cell component | nucleic acid binding activity;kinase activity;other molecular function | 18746 | ENSMUSG00000032294 | Pkm | mmu:18746; P52480; Q3TBV8; Q3TBW5; Q3TC59; Q3U1X3; Q3U5P6; Q4VC20; Q64484; Q91YI8; Q9CWB1 | Glycolysis and gluconeogenesis; Purine metabolism | Neutrophil degranulation; Pyruvate metabolism; Glycolysis; Regulation of pyruvate metabolism | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.972868731003358 | 0.958705855138011 | 0.959522188921769 | 224031.9482756436 | 1.1706302394897154E7 | 1.6687028973496003E7 | 1.3595916090065738E7 | 3.1698865102110166E7 | |
| P63017 | Heat shock cognate 71 kDa protein [OS=Mus musculus] | 161.557 | 53 | 28 | 572 | 23 | 646 | 70.8 | cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component | signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function | 15481 | ENSMUSG00000015656 | Hspa8 | mmu:15481; P08109; P12225; P63017; Q3U6R0; Q3U764; Q3U7D7; Q3U7E2; Q3U9B4; Q3U9G0; Q3UGM0; Q5FWJ6; Q62373; Q62374; Q62375; Q6NZD0 | Mapk signaling pathway; Exercise-induced circadian regulation | Neutrophil degranulation; mRNA Splicing - Major Pathway; Regulation of HSF1-mediated heat shock response; PKR-mediated signaling; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis; Attenuation phase; Lysosome Vesicle Biogenesis; GABA synthesis, release, reuptake and degradation; AUF1 (hnRNP D0) binds and destabilizes mRNA; Protein methylation | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.953011140807089 | 0.709593139419252 | 0.587315224195015 | 232221.67704249235 | 1.5723480869725833E7 | 2.2348098618015703E7 | 1.2001189016638666E7 | 3.440867978172333E7 | |
| Q9JHU4 | Cytoplasmic dynein 1 heavy chain 1 [OS=Mus musculus] | 161.009 | 14 | 55 | 258 | 55 | 4644 | 531.7 | cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes | cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 13424 | ENSMUSG00000018707 | Dync1h1 | E9QM71; mmu:13424; Q9JHU4 | MHC class II antigen presentation; Neutrophil degranulation; Separation of Sister Chromatids; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; COPI-mediated anterograde transport; Recruitment of NuMA to mitotic centrosomes; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-independent Golgi-to-ER retrograde traffic; Aggrephagy; Anchoring of the basal body to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; AURKA Activation by TPX2 | 0.591873375996003 | 0.826895204418257 | 0.758743075163871 | 0.936818656936794 | 0.987352798667733 | 0.695927216301667 | 0.953305976192702 | 294620.0253220563 | 451351.8596347517 | 1275535.4534856554 | 1462326.6297541 | 5162177.518126 | ||
| Q99K41 | EMILIN-1 [OS=Mus musculus] | 157.011 | 31 | 21 | 244 | 21 | 1017 | 107.5 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 100952 | ENSMUSG00000029163 | Emilin1 | mmu:100952; Q99K41 | Molecules associated with elastic fibres | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.64186124184599 | 0.0921665663508908 | 0.491906845171331 | 1671715.86234765 | 5498413.09956387 | 384416.66366236034 | 2364922.89508055 | |||
| Q61879 | Myosin-10 [OS=Mus musculus] | 146 | 19 | 31 | 236 | 20 | 1976 | 228.9 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;nucleic acid binding activity;other molecular function | 77579 | ENSMUSG00000020900 | Myh10 | mmu:77579; Q5SV63; Q61879 | Regulation of actin cytoskeleton | RHO GTPases activate PAKs | 0.705689538076567 | 0.506231596289679 | 0.676239752697828 | 0.933545599871938 | 0.990096171400123 | 0.953146340313072 | 0.921444667457376 | 123378.89612673952 | 266023.60455562966 | 458865.269073755 | 562909.3462758837 | 1089526.38375758 | |
| Cont_P00761 | Trypsin OS=Sus scrofa OX=9823 PE=1 SV=1 | 143.502 | 62 | 11 | 3859 | 10 | 231 | 24.4 | protein metabolism;other biological processes | non-structural extracellular | other molecular function | 0.254996071775817 | 0.172153475402034 | 0.357784551188889 | 0.34040294575649 | 0.740968241512781 | 0.960577895552113 | 0.148582186670595 | 5.863252009900073E9 | 3.334729419178533E9 | 2.1792138371661735E9 | 4.479417756781787E9 | 2.35988129070601E9 | |||||||
| P20029 | Endoplasmic reticulum chaperone BiP [OS=Mus musculus] | 142.966 | 48 | 25 | 434 | 23 | 655 | 72.4 | protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component | enzyme regulator activity;translation activity;other molecular function | 14828 | ENSMUSG00000026864 | Hspa5 | mmu:14828; O35642; P20029; Q3UFF2; Q61630 | Mapk signaling pathway | Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Regulation of HSF1-mediated heat shock response | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.769590657123576 | 0.985707795620743 | 0.888702680095366 | 7392689.481756757 | 8222965.927916382 | 8403011.594768586 | 1.57890948929286E7 | ||
| Cont_P13647 | Keratin, type II cytoskeletal 5 OS=Homo sapiens OX=9606 GN=KRT5 PE=1 SV=3 | 142.395 | 51 | 34 | 500 | 20 | 590 | 62.3 | cell organization and biogenesis;other biological processes | cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;cytoskeletal activity;other molecular function | 3852 | ENSG00000186081 | KRT5 | hsa:3852; P13647; Q6PI71; Q6UBJ0; Q8TA91 | Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin; Developmental Lineage of Mammary Stem Cells; Developmental Lineage of Mammary Gland Myoepithelial Cells; Type I hemidesmosome assembly | 0.786915923361782 | 0.847457711018997 | 0.707170943024881 | 0.746833150482801 | 0.714156118974909 | 0.2733017775894 | 2.49132633766938E-5 | 5615099.536380176 | 7868513.182470503 | 9974982.226041706 | 2.8752414910160065E7 | 1.3998817771053001E7 | ||
| Cont_P08779 | Keratin, type I cytoskeletal 16 OS=Homo sapiens OX=9606 GN=KRT16 PE=1 SV=4 | 140.751 | 54 | 25 | 569 | 12 | 473 | 51.2 | cell organization and biogenesis;stress response;other biological processes | plasma membrane;cytosol;cytoskeleton | cytoskeletal activity | 3868 | ENSG00000186832 | KRT16 | A8K488; hsa:3868; P08779; P30654; Q16402; Q9UBG8 | Vitamin D receptor pathway | Formation of the cornified envelope | 0.941324060398065 | 0.961351301268194 | 0.761460393544015 | 0.887279041944908 | 0.493923182294169 | 0.895302208460818 | 3.1065941501805E-4 | 1275668.1444026066 | 3908256.3409277797 | 2249474.51763106 | 5401589.786976026 | 2569640.8216647534 | |
| Cont_P02465 | Collagen alpha-2(I) chain OS=Bos taurus OX=9913 GN=COL1A2 PE=1 SV=2 | 139.99 | 18 | 19 | 445 | 3 | 1364 | 129 | non-structural extracellular;extracellular matrix | extracellular structural activity;other molecular function | 282188 | ENSBTAG00000013472 | COL1A2 | A6QP13; bta:282188; O62649; P02465 | Inflammatory response pathway; Focal adhesion | Fibronectin matrix formation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Collagen degradation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; Collagen chain trimerization; GPVI-mediated activation cascade; Platelet Aggregation (Plug Formation); Platelet Adhesion to exposed collagen; GP1b-IX-V activation signalling | 0.483779141493222 | 0.876027096029978 | 0.421836754550416 | 0.488872343346086 | 0.076245756040016 | 0.549852418071669 | 0.432748651973214 | 70110.45197339094 | 85775.39066064726 | 163731.944383145 | 48702.045776696206 | 54970.44581499727 | ||
| Cont_P12763 | Alpha-2-HS-glycoprotein OS=Bos taurus OX=9913 GN=AHSG PE=1 SV=2 | 132.772 | 50 | 16 | 1191 | 16 | 359 | 38.4 | stress response;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component | enzyme regulator activity | 280988 | AHSG | A6QLF7; bta:280988; P12763 | Neutrophil degranulation; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 0.573667790345329 | 0.793013134473823 | 0.624272910267193 | 0.36488675645736 | 0.268930374946741 | 0.335956814949331 | 0.913214993335179 | 6.882384659684638E8 | 8.712402787486216E8 | 6.41500953397899E8 | 4.440672611032756E8 | 7.064361313920757E8 | |||
| P07901 | Heat shock protein HSP 90-alpha [OS=Mus musculus] | 132.382 | 43 | 25 | 402 | 16 | 733 | 84.7 | cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component | signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function | 15519 | ENSMUSG00000021270 | Hsp90aa1 | mmu:15519; P07901 | EBV LMP1 signaling; Focal adhesion: PI3K-Akt-mTOR signaling pathway; IL-6 signaling pathway; IL-2 signaling pathway | Regulation of necroptotic cell death; Recruitment of NuMA to mitotic centrosomes; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of actin dynamics for phagocytic cup formation; Neutrophil degranulation; Downregulation of ERBB2 signaling; Anchoring of the basal body to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; AURKA Activation by TPX2; Extra-nuclear estrogen signaling; Attenuation phase; Estrogen-dependent gene expression; Sema3A PAK dependent Axon repulsion; VEGFR2 mediated vascular permeability; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation; DDX58/IFIH1-mediated induction of interferon-alpha/beta; eNOS activation; HSF1 activation; RHOBTB2 GTPase cycle; Drug-mediated inhibition of ERBB2 signaling | 1.65082956259427E-17 | 0.508730894200713 | 1.50457038391225E-17 | 0.251664970734015 | 0.788764875934969 | 0.968364585136618 | 0.745600589176001 | 138049.65358917884 | 1667357.9717776468 | 3968795.71909318 | 1606774.576019598 | 6014683.841021903 | |
| Q02819 | Nucleobindin-1 [OS=Mus musculus] | 131.152 | 51 | 21 | 299 | 21 | 459 | 53.4 | signal transduction | non-structural extracellular;other membranes;ER/Golgi | enzyme regulator activity;nucleic acid binding activity;other molecular function | 18220 | ENSMUSG00000030824 | Nucb1 | mmu:18220; Q02819; Q3TU42; Q9CWA1; Q9D8J4; Q9DBL3 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 0.130903496983571 | 0.340647566778883 | 0.397987186613988 | 0.958122559708965 | 30635.69892492515 | 5493436.34719679 | 1.9240052036173E7 | 2379424.5332984333 | 6548209.148806977 | ||
| Q91V92 | ATP-citrate synthase [OS=Mus musculus] | 129.973 | 32 | 28 | 237 | 28 | 1091 | 119.7 | other metabolic processes | cytosol | other molecular function | 104112 | ENSMUSG00000020917 | Acly | mmu:104112; Q91V92 | Fatty acid biosynthesis | Neutrophil degranulation; Fatty acyl-CoA biosynthesis | 0.230775890814232 | 0.371468864113786 | 0.437429424171984 | 0.509570119936397 | 0.98558531112136 | 0.643183834410259 | 0.922580167429744 | 27537.414327710998 | 1276919.6113413726 | 2339759.4103227933 | 644183.8162072281 | 1777761.9344937534 | |
| A2ASQ1 | Agrin [OS=Mus musculus] | 128.989 | 18 | 26 | 227 | 26 | 1950 | 207.4 | cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cell component | signal transduction activity or receptor binding;other molecular function | 11603 | ENSMUSG00000041936 | Agrn | A2ASP9; A2ASQ0; A2ASQ1; B2RWU1 | Primary focal segmental glomerulosclerosis (FSGS) | ECM proteoglycans; Retinoid metabolism and transport; Glycosaminoglycan-protein linkage region biosynthesis; HS-GAG biosynthesis; HS-GAG degradation; Formation of the dystrophin-glycoprotein complex (DGC) | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.972791368602389 | 0.686318824668434 | 0.846971399004193 | 1695001.2322350666 | 3018900.06344302 | 1028829.4241236168 | 2045725.4701757336 | ||
| Q61508 | Extracellular matrix protein 1 [OS=Mus musculus] | 127.379 | 45 | 18 | 358 | 18 | 559 | 62.8 | stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular | signal transduction activity or receptor binding;other molecular function | 13601 | ENSMUSG00000028108 | Ecm1 | mmu:13601; Q3U5Q5; Q61508 | Platelet degranulation | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 0.121600547823456 | 0.795351011232032 | 1.51989274634622E-7 | 0.592370654746194 | 74811.39241511819 | 5.132626536679041E7 | 6.196550035866306E7 | 3515293.344106073 | 1.1331897286900917E7 | ||
| Cont_P04259 | Keratin, type II cytoskeletal 6B OS=Homo sapiens OX=9606 GN=KRT6B PE=1 SV=5 | 126.901 | 47 | 30 | 442 | 4 | 564 | 60 | cell organization and biogenesis;other biological processes | cytosol;cytoskeleton | bone, tooth or skin structural activity;cytoskeletal activity | 3854 | ENSG00000185479 | KRT6B | hsa:3854; P04259; P48669 | Formation of the cornified envelope | 0.857251372850113 | 0.868132360832926 | 0.758743075163871 | 0.801271130817871 | 0.340133476321195 | 0.937453377971347 | 0.00123883404563536 | 298970.1410949 | 1156058.5455969477 | 510017.07482617133 | 1115770.6869766254 | 854901.7358096777 | ||
| P17182 | Alpha-enolase [OS=Mus musculus] | 126.804 | 60 | 19 | 244 | 16 | 434 | 47.1 | other metabolic processes;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;other cell component | nucleic acid binding activity;other molecular function | 13806; 433182 | ENSMUSG00000059040; ENSMUSG00000063524 | Eno1 | mmu:13806; mmu:433182; P17182; Q99KT7; Q9DCY7 | Glycolysis and gluconeogenesis | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.789540446904924 | 0.858218537342417 | 0.989544231571828 | 47358.53377381337 | 9473047.660860082 | 1.1146559483992001E7 | 1.3905788568310633E7 | 2.89416009584274E7 | ||
| P08113 | Endoplasmin [OS=Mus musculus] | 126.346 | 39 | 26 | 329 | 25 | 802 | 92.4 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cell component | signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function | 22027 | ENSMUSG00000020048 | Hsp90b1 | mmu:22027; P08113; P11427 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Hypoxia-dependent self-renewal of myoblasts | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Scavenging by Class A Receptors; Trafficking and processing of endosomal TLR; Interleukin-4 and Interleukin-13 signaling | 0.107476768049312 | 0.0104456807471941 | 1.50457038391225E-17 | 0.205304099107124 | 0.840785133352029 | 0.866766165039268 | 0.896996950298791 | 52582.03853978356 | 4030450.84914005 | 5006439.15200075 | 6037105.20140975 | 1.2434595462188734E7 | |
| P58252 | Elongation factor 2 [OS=Mus musculus] | 126.048 | 37 | 31 | 378 | 30 | 858 | 95.3 | cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;translational apparatus;other cell component | cytoskeletal activity;translation activity;nucleic acid binding activity;other molecular function | 13629 | ENSMUSG00000034994 | Eef2 | mmu:13629; P58252; Q544E4 | Translation factors | Neutrophil degranulation; Protein methylation; Peptide chain elongation; Synthesis of diphthamide-EEF2 | 0.299809054080284 | 0.188334321166369 | 0.471929633209224 | 0.84258396038376 | 0.97504218639442 | 0.866546043492515 | 0.950878070645738 | 229633.38558146535 | 6414138.274151959 | 1.0566307796994643E7 | 4859646.5618234025 | 1.3065706600835832E7 | |
| Cont_P02538 | Keratin, type II cytoskeletal 6A OS=Homo sapiens OX=9606 GN=KRT6A PE=1 SV=3 | 123.757 | 47 | 30 | 454 | 3 | 564 | 60 | cell organization and biogenesis;stress response;other biological processes | cytosol;cytoskeleton | bone, tooth or skin structural activity;cytoskeletal activity | 3853 | ENSG00000205420 | KRT6A | A4QPC1; hsa:3853; P02538; P48667; Q08AR4; Q6NT67; Q96CL4 | Ectoderm differentiation; Ectoderm differentiation; Pancreatic cancer subtypes | Formation of the cornified envelope | 0.892533464536408 | 0.964633336683333 | 0.745886066139481 | 0.84258396038376 | 0.574739141583974 | 0.709593139419252 | 5.66461038960431E-4 | 2182876.549653717 | 4785085.111074816 | 3779160.7730984767 | 8485501.699692694 | 3982846.61307857 | |
| P97298 | Pigment epithelium-derived factor [OS=Mus musculus] | 123.502 | 47 | 16 | 346 | 12 | 417 | 46.2 | cell cycle OR cell proliferation;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | enzyme regulator activity | 20317 | ENSMUSG00000000753 | Serpinf1 | mmu:20317; O70629; O88691; P97298 | 1.65082956259427E-17 | 0.227296093012204 | 0.434748506750565 | 0.770205086382264 | 0.174886032348437 | 0.300753028734261 | 0.891044455497809 | 462579.17347644636 | 1.46490289953418E7 | 7.121805491857927E7 | 5921015.69252881 | 1.5757205380580032E7 | |||
| Q70E20 | Sushi, nidogen and EGF-like domain-containing protein 1 [OS=Mus musculus] | 122.942 | 19 | 22 | 287 | 22 | 1403 | 151.5 | cell adhesion | non-structural extracellular;extracellular matrix | other molecular function | 208777 | Sned1 | A6H6I3; mmu:208777; Q70E20; Q810H2; Q8BMD9 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.869908412860824 | 0.817293288705596 | 0.880760468933162 | 37861.533059704365 | 3293936.3484006864 | 6267209.5561869135 | 4995161.517920501 | 1.4223395042125002E7 | ||||
| P13020 | Gelsolin [OS=Mus musculus] | 122.934 | 35 | 22 | 377 | 9 | 780 | 85.9 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 227753 | ENSMUSG00000026879 | Gsn | mmu:227753; P13020; Q3UPB1; Q8R590 | Regulation of actin cytoskeleton | Neutrophil degranulation; Caspase-mediated cleavage of cytoskeletal proteins | 0.440427841758307 | 0.396306424610341 | 0.186266168629733 | 0.379422692457324 | 0.994546642862744 | 0.709593139419252 | 0.793590033024783 | 1139775.9088509877 | 6438031.44422588 | 9825643.045518672 | 1.1033925013460701E7 | 2.9144067496602204E7 | |
| Q61398 | Procollagen C-endopeptidase enhancer 1 [OS=Mus musculus] | 120.4 | 40 | 14 | 323 | 14 | 468 | 50.1 | protein metabolism;other biological processes | enzyme regulator activity;other molecular function | 18542 | ENSMUSG00000029718 | Pcolce | mmu:18542; O35113; Q61398 | mRNA processing | Collagen biosynthesis and modifying enzymes; Crosslinking of collagen fibrils | 1.65082956259427E-17 | 1.8644578313253E-17 | 0.151224536345852 | 0.288320039261486 | 0.789540446904924 | 0.0895861566882082 | 0.711902858921665 | 84503.2651712337 | 2.52047208020085E7 | 2.958750643636163E7 | 7672570.19904635 | 1.2538308810459368E7 | ||
| P26039 | Talin-1 [OS=Mus musculus] | 118.226 | 15 | 30 | 153 | 30 | 2541 | 269.7 | cell adhesion;cell organization and biogenesis;signal transduction | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;other molecular function | 21894 | ENSMUSG00000028465 | Tln1 | A2AIM8; mmu:21894; P26039; Q8VEF0 | Primary focal segmental glomerulosclerosis (FSGS); Integrin-mediated cell adhesion; Focal adhesion | Platelet degranulation ; MAP2K and MAPK activation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; Smooth Muscle Contraction; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 0.958262397335385 | 0.994542145304377 | 0.680632778351053 | 0.738983404380581 | 0.783910800136359 | 0.87222702623065 | 0.535066779633529 | 147890.2697082064 | 165904.24421521465 | 567933.664164035 | 286851.2614141297 | 2291518.0404973766 | |
| Q8BPB5 | EGF-containing fibulin-like extracellular matrix protein 1 [OS=Mus musculus] | 117.738 | 49 | 15 | 220 | 15 | 493 | 54.9 | protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes | extracellular matrix | signal transduction activity or receptor binding;kinase activity;other molecular function | 216616 | ENSMUSG00000020467 | Efemp1 | mmu:216616; Q6Y3N6; Q8BPB5 | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 0.376780684027729 | 0.983440558239231 | 0.145805028390539 | 0.982581944728745 | 29995.485006469138 | 4441372.613318663 | 7007290.288389671 | 1370373.3251651835 | 3606517.1409647237 | |||
| P09411 | Phosphoglycerate kinase 1 [OS=Mus musculus] | 116.462 | 57 | 18 | 287 | 18 | 417 | 44.5 | protein metabolism;other metabolic processes;stress response;other biological processes | non-structural extracellular;other membranes;cytosol;mitochondrion;other cell component | kinase activity;other molecular function | 18655 | ENSMUSG00000062070 | Pgk1 | mmu:18655; P09411; Q3TPE6; Q3UKV8; Q5XJE7 | Glycolysis and gluconeogenesis | Gluconeogenesis; Glycolysis | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.766862952867809 | 0.820281310709571 | 0.891044455497809 | 46750.53578358531 | 3210948.6178334034 | 3594147.655304653 | 4500077.619792943 | 1.4795712145397767E7 | |
| P27773 | Protein disulfide-isomerase A3 [OS=Mus musculus] | 115.891 | 55 | 23 | 291 | 23 | 505 | 56.6 | cell adhesion;cell organization and biogenesis;stress response;signal transduction;other biological processes | non-structural extracellular;other membranes;ER/Golgi;other cell component | nucleic acid binding activity;other molecular function | 14827 | ENSMUSG00000027248 | Pdia3 | mmu:14827; P27773; Q3TEI9; Q3TIL2; Q3UZK8; Q8C2F4; Q99LF6 | ER-Phagosome pathway; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Calnexin/calreticulin cycle | 0.9135584231482 | 0.736536116100563 | 0.498293621965442 | 0.874168055361729 | 0.862063111456553 | 0.881496352314601 | 0.939046770372612 | 196243.61956605766 | 5161827.016313557 | 6480316.532156386 | 7238345.98431998 | 1.5315044241817234E7 | ||
| P10107 | Annexin A1 [OS=Mus musculus] | 115.566 | 64 | 18 | 270 | 18 | 346 | 38.7 | cell organization and biogenesis;stress response;transport;signal transduction;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component | enzyme regulator activity;other molecular function | 16952 | ENSMUSG00000024659 | Anxa1 | mmu:16952; P10107 | Spinal cord injury; Prostaglandin synthesis and regulation | G alpha (q) signalling events; G alpha (i) signalling events; Formyl peptide receptors bind formyl peptides and many other ligands | 1.65082956259427E-17 | 0.105053536950499 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.401885831342676 | 0.529099828181544 | 0.924766494197286 | 8983.410658903753 | 1675870.316312303 | 6017153.19339518 | 4211649.667813237 | 1.08370832078509E7 | |
| Cont_Q2KJF1 | Alpha-1B-glycoprotein OS=Bos taurus OX=9913 GN=A1BG PE=1 SV=1 | 115.502 | 48 | 14 | 224 | 14 | 503 | 53.5 | signal transduction | non-structural extracellular;plasma membrane;other membranes | 518955 | A1BG | bta:518955; Q2KJF1 | Platelet degranulation ; Neutrophil degranulation | 0.635218461842139 | 0.655487072215252 | 0.641514600397631 | 0.360991986803736 | 0.696358249006924 | 0.601376052147163 | 0.891044455497809 | 9385194.584847162 | 9820849.23751892 | 8859077.038578315 | 6762503.63408608 | 1.0317459698123023E7 | ||||
| Cont_Q3MHN5 | Vitamin D-binding protein OS=Bos taurus OX=9913 GN=GC PE=2 SV=1 | 113.599 | 55 | 20 | 319 | 20 | 474 | 53.3 | other metabolic processes;transport | non-structural extracellular;other cell component | transporter activity;cytoskeletal activity;other molecular function | 530076 | GC | bta:530076; Q3MHN5 | 0.549057967251154 | 0.804331105646976 | 0.579435037816218 | 0.479472599858427 | 0.139718417146003 | 0.570795727084329 | 0.421365656927814 | 1.2784681703575822E7 | 1.5974245944817802E7 | 1.026921939097026E7 | 1.0785165311962552E7 | 1.4618596373270534E7 | ||||
| P17742 | Peptidyl-prolyl cis-trans isomerase A [OS=Mus musculus] | 113.527 | 60 | 9 | 369 | 9 | 164 | 18 | cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes | non-structural extracellular;cytosol;nucleus;other cell component | signal transduction activity or receptor binding;other molecular function | 268373 | ENSMUSG00000071866 | Ppia | mmu:268373; P17742; Q9CWJ5; Q9R137 | Neutrophil degranulation; Basigin interactions | 0.100219677394751 | 0.099382125133403 | 1.50457038391225E-17 | 1.70336894001643E-17 | 0.696358249006924 | 0.937453377971347 | 0.331144967260478 | 5533917.143041036 | 1.0145464905716315E7 | 3.610988970082183E7 | 1.0696784170781441E7 | 4.607074026803666E7 | ||
| Q69ZN7 | Myoferlin [OS=Mus musculus] | 112.647 | 22 | 36 | 227 | 36 | 2048 | 233.2 | cell organization and biogenesis;other metabolic processes;stress response;other biological processes | plasma membrane;other membranes;nucleus | other molecular function | 226101 | ENSMUSG00000048612 | Myof | mmu:226101; Q69ZN7; Q7TMG0; Q80V33; Q8BU64; Q8BU70; Q8BUC1; Q8BVY6; Q8C0D1; Q8R3B4 | 0.73657372909066 | 0.964709887217926 | 0.888974672311279 | 0.930955411749965 | 0.877818946381645 | 0.609903091678244 | 0.975029032316037 | 74563.786625436 | 322363.41862436634 | 911704.7850761963 | 1104935.9693987637 | 3065805.015040973 | |||
| P26041 | Moesin [OS=Mus musculus] | 112.068 | 47 | 28 | 353 | 19 | 577 | 67.7 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function | 17698 | ENSMUSG00000031207 | Msn | B1AX70; mmu:17698; P26041; Q3UL28; Q8BSN4 | Regulation of actin cytoskeleton | Recycling pathway of L1 | 1.65082956259427E-17 | 0.0604972675946614 | 1.50457038391225E-17 | 0.157138696252226 | 0.682171843898269 | 0.97925982662951 | 0.954396180425051 | 3564499.916018247 | 9136364.2843242 | 1.7052591672350097E7 | 1.120013397828275E7 | 1.9030746620886367E7 | |
| P05064 | Fructose-bisphosphate aldolase A [OS=Mus musculus] | 112.015 | 66 | 18 | 261 | 18 | 364 | 39.3 | cell organization and biogenesis;other metabolic processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | other molecular function | 11674 | ENSMUSG00000030695 | Aldoa | mmu:11674; P05064 | Glycolysis and gluconeogenesis | Platelet degranulation ; Neutrophil degranulation; Gluconeogenesis; Glycolysis | 0.101571037453114 | 0.00616383846364181 | 1.50457038391225E-17 | 0.0771819601934254 | 0.828577692034317 | 0.988377544628277 | 0.953305976192702 | 21908.055682018665 | 4319055.57861477 | 4893427.94836492 | 4518789.603964283 | 1.0653934694757948E7 | |
| B2RQC6 | Multifunctional protein CAD [OS=Mus musculus] | 111.853 | 18 | 32 | 111 | 32 | 2225 | 243.1 | other metabolic processes;stress response;transport;developmental processes;other biological processes | cytosol;nucleus;other cell component | kinase activity;other molecular function | 69719 | ENSMUSG00000013629 | Cad | B2RQC6; B7ZN27; mmu:69719 | Mechanisms associated with pluripotency | Pyrimidine biosynthesis | 0.69394578118832 | 0.6681512188534 | 0.666244110962191 | 0.963127218853016 | 0.968897093792999 | 0.798180783050573 | 0.621633895543644 | 34439.61575478624 | 448793.6641228067 | 957747.5456383955 | 139659.55402474166 | 452794.3373622177 | |
| Q8BND5 | Sulfhydryl oxidase 1 [OS=Mus musculus] | 111.186 | 35 | 22 | 242 | 22 | 748 | 82.7 | cell organization and biogenesis;other biological processes | non-structural extracellular;other membranes;ER/Golgi | other molecular function | 104009 | ENSMUSG00000033684 | Qsox1 | mmu:104009; Q3TDY9; Q3TE19; Q3TR29; Q3UEL4; Q8BND5; Q8K041; Q9DBL6 | Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Neutrophil degranulation | 1.65082956259427E-17 | 1.8644578313253E-17 | 1.50457038391225E-17 | 0.162753188077458 | 0.696358249006924 | 0.331332346840573 | 0.877612009404373 | 25068.200750320597 | 3849451.1157268733 | 1.052758137572049E7 | 1818282.5759143168 | 5040172.36278756 |
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| Accession | Description | Sum PEP Score | Biological Process | Cellular Component | Molecular Function | Entrez Gene ID | Ensembl Gene ID | Gene Symbol | Gene ID | WikiPathways | Reactome Pathways | Abundance Ratio Adj. P-Value: (LQ_6h) / (FM_control) | Abundance Ratio Adj. P-Value: (LQ_16h) / (FM_control) | FM_AVERAGE | LQ6h_AVERAGE | LQ16h_AVERAGE | FC_ LQ6h vs NC | FC_ LQ16h vs FM | |||||||
| P11276 | Fibronectin [OS=Mus musculus] | 867.353 | cell adhesion;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi | signal transduction activity or receptor binding;enzyme regulator activity;other molecular function | 14268 | ENSMUSG00000026193 | Fn1 | G5E8B8; mmu:14268; P11276; Q61567; Q61568; Q61569; Q64233; Q80UI4 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Inflammatory response pathway; Regulation of actin cytoskeleton; Comprehensive IL-17A signaling; Focal adhesion | ECM proteoglycans; Platelet degranulation ; Cell surface interactions at the vascular wall; Syndecan interactions; MAP2K and MAPK activation; Integrin cell surface interactions; Molecules associated with elastic fibres; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Fibronectin matrix formation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; Degradation of the extracellular matrix; Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells; MET activates PTK2 signaling; GPER1 signaling | 0.00584906503121538 | 0.0844744457809114 | 2.76414533778046E7 | 2.022341523870097E8 | 2.12696235413058E8 | 2.8711212743884964 | 2.9438891195215318 | |||||||
| P11087 | Collagen alpha-1(I) chain [OS=Mus musculus] | 797.017 | cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12842 | ENSMUSG00000001506 | Col1a1 | mmu:12842; P11087; Q53WT0; Q60635; Q61367; Q61427; Q63919; Q6PCL3; Q810J9 | Osteoblast signaling; Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Comprehensive IL-17A signaling; Focal adhesion | Cell surface interactions at the vascular wall; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ECM proteoglycans; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; GPVI-mediated activation cascade; GP1b-IX-V activation signalling; Platelet Adhesion to exposed collagen; Platelet Aggregation (Plug Formation); MET activates PTK2 signaling | 1.8644578313253E-17 | 1.65082956259427E-17 | 772438.0834537543 | 2.0798706453114033E8 | 5.92854376184685E8 | 8.07285879426701 | 9.58404276622316 | |||||||
| Q01149 | Collagen alpha-2(I) chain [OS=Mus musculus] | 773.662 | cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12843 | ENSMUSG00000029661 | Col1a2 | mmu:12843; Q01149; Q8CGA5 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Focal adhesion | Crosslinking of collagen fibrils; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; ECM proteoglycans; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; GPVI-mediated activation cascade; GP1b-IX-V activation signalling; Platelet Adhesion to exposed collagen; Platelet Aggregation (Plug Formation); MET activates PTK2 signaling | 1.8644578313253E-17 | 1.65082956259427E-17 | 182180.3275564673 | 1.7308392932505235E8 | 3.475967473053053E8 | 9.891888882254342 | 10.89783168612198 | |||||||
| P08121 | Collagen alpha-1(III) chain [OS=Mus musculus] | 695.631 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | extracellular matrix;other cell component | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 12825 | ENSMUSG00000026043 | Col3a1 | mmu:12825; P08121; Q61429; Q9CRN7 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Focal adhesion | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ECM proteoglycans; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; MET activates PTK2 signaling | 1.8644578313253E-17 | 1.65082956259427E-17 | 454748.1180174556 | 6.282890624937943E7 | 2.8394661715058166E8 | 7.110216987795516 | 9.286336341446717 | |||||||
| Q9QXS1 | Plectin [OS=Mus musculus] | 659.702 | cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component | cytoskeletal activity;other molecular function | 18810 | ENSMUSG00000022565 | Plec | E9QN87; mmu:18810; Q6S384; Q6S389; Q6S394; Q9CS65; Q9QUT2; Q9QXQ8; Q9QXQ9; Q9QXR0; Q9QXR1; Q9QXR2; Q9QXR3; Q9QXR4; Q9QXR5; Q9QXR6; Q9QXR7; Q9QXR8; Q9QXR9; Q9QXS0; Q9QXS1; Q9QXS2; Q9QXS3 | Alpha 6 beta 4 integrin signaling pathway; EGFR1 signaling pathway | Type I hemidesmosome assembly; Caspase-mediated cleavage of cytoskeletal proteins | 0.714932595871944 | 0.481729871164266 | 309922.514176982 | 4599273.114185064 | 1.6676006673579365E7 | 3.891426402670929 | 5.749722481744953 | |||||||
| P08122 | Collagen alpha-2(IV) chain [OS=Mus musculus] | 526.992 | RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix | extracellular structural activity | 12827 | ENSMUSG00000031503 | Col4a2 | mmu:12827; P08122; Q3B7C2; Q3TPV9; Q61375; Q66JS5; Q6RCT6; Q6RCT7; Q6U9X1; Q8BPI9; Q8BPK3; Q91VI3 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Focal adhesion | Laminin interactions; Signaling by PDGF; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions | 0.64759425713406 | 0.352816378116182 | 1393534.8123072747 | 1.3981747232493034E7 | 5.0194805286054574E7 | 3.3267237103227703 | 5.170717117454539 | |||||||
| Q3U962 | Collagen alpha-2(V) chain [OS=Mus musculus] | 518.514 | cell organization and biogenesis;developmental processes;other biological processes | extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12832 | ENSMUSG00000026042 | Col5a2 | mmu:12832; Q3TVR2; Q3U962; Q3UHK7; Q3UTT4; Q3V1J6; Q61431; Q7TMS0; Q80VS8 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions | 0.961254912149485 | 0.861384746267066 | 2.4419841082594533E7 | 1.5753424919239333E7 | 4.592471970087584E7 | -0.6323882956741324 | 0.9112171042444063 | |||||||
| Q05793 | Basement membrane-specific heparan sulfate proteoglycan core protein [OS=Mus musculus] | 507.28 | cell organization and biogenesis;transport;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;ER/Golgi | other molecular function | 15530 | Hspg2 | mmu:15530; Q05793 | 0.382764581022518 | 0.332090710292395 | 171009.25706548532 | 2.1355561683383033E7 | 4.109385814368304E7 | 6.964393610173966 | 7.908704552577742 | ||||||||||
| Q61554 | Fibrillin-1 [OS=Mus musculus] | 499.202 | cell adhesion;other metabolic processes;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 14118 | ENSMUSG00000027204 | Fbn1 | A2AQ53; mmu:14118; Q60826; Q61554 | Comprehensive IL-17A signaling | Integrin cell surface interactions; Degradation of the extracellular matrix; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; TGF-beta receptor signaling activates SMADs; Molecules associated with elastic fibres | 0.0840496117897429 | 0.0596853092747711 | 81731.837224874 | 2.17735814942991E7 | 5.216417896597137E7 | 8.057464853046588 | 9.317945570971949 | |||||||
| Q8BTM8 | Filamin-A [OS=Mus musculus] | 493.069 | cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;other molecular function | 192176 | ENSMUSG00000031328 | Flna | B7FAV0; O54934; Q7TQI1; Q8BLK1; Q8BTM8; Q8BTN7; Q8VHX5; Q8VHX8; Q99KQ2 | Mapk signaling pathway; Focal adhesion | Platelet degranulation ; Cell-extracellular matrix interactions; RHO GTPases activate PAKs; GP1b-IX-V activation signalling | 0.493514006575528 | 0.0844935092512095 | 218480.8558628913 | 4952287.405198824 | 1.1395384793048913E7 | 4.502516267694667 | 5.704798960580473 | |||||||
| P02463 | Collagen alpha-1(IV) chain [OS=Mus musculus] | 487.707 | cell organization and biogenesis;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix | extracellular structural activity;other molecular function | 12826 | ENSMUSG00000031502 | Col4a1 | mmu:12826; P02463; Q3UHJ4; Q3UJE7; Q3UQV2; Q53X35; Q6GQS7; Q6PHB5; Q99LQ8 | Spinal cord injury; Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Laminin interactions; Signaling by PDGF; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions | 0.68008321917751 | 0.604225174343649 | 262271.417553364 | 4620515.057112186 | 2.1463797748519864E7 | 4.138921184627833 | 6.3547009644888925 | |||||||
| Q60847 | Collagen alpha-1(XII) chain [OS=Mus musculus] | 480.266 | cell adhesion;developmental processes | other cell component | 12816 | ENSMUSG00000032332 | Col12a1 | mmu:12816; P70322; Q60847 | Assembly of collagen fibrils and other multimeric structures; Collagen chain trimerization; Collagen degradation | 1.8644578313253E-17 | 0.0975092237649803 | 80180.17821443231 | 5.1736330625803865E7 | 2.9952489655588504E7 | 9.33371639573238 | 8.545214585562245 | |||||||||
| Q8VDD5 | Myosin-9 [OS=Mus musculus] | 418.364 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;stress response;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;other molecular function | 17886 | ENSMUSG00000022443 | Myh9 | mmu:17886; Q3UHT9; Q3UHU4; Q6KAN6; Q811I2; Q8VDD5 | Primary focal segmental glomerulosclerosis (FSGS) | RHO GTPases activate PAKs; Regulation of actin dynamics for phagocytic cup formation | 0.0382609387499984 | 0.156498497144098 | 100319.6147091511 | 5176534.940650649 | 8067345.413832072 | 5.68931109493806 | 6.32941841059592 | |||||||
| Cont_P02453 | Collagen alpha-1(I) chain OS=Bos taurus OX=9913 GN=COL1A1 PE=1 SV=3 | 414.689 | cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | 282187 | ENSBTAG00000013103 | COL1A1 | bta:282187; P02453; Q3MHM2 | Inflammatory response pathway; Osteoblast signaling; Focal adhesion | Fibronectin matrix formation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Collagen degradation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; Collagen chain trimerization; GPVI-mediated activation cascade; Platelet Aggregation (Plug Formation); Platelet Adhesion to exposed collagen; GP1b-IX-V activation signalling | 0.579410556046386 | 0.800889767710788 | 228542.54091026666 | 3262486.7198886867 | 3910059.36528234 | 3.8354373904758865 | 4.096655873055708 | |||||||
| Cont_P02769 | Albumin OS=Bos taurus OX=9913 GN=ALB PE=1 SV=4 | 390.555 | stress response;other biological processes | non-structural extracellular;other cell component | nucleic acid binding activity;other molecular function | 280717 | ALB | A5PJX3; bta:280717; O02787; P02769; P04277; Q3SZR2 | 0.650544967914241 | 0.520832629933248 | 2.7142766432154403E9 | 2.9099571807541137E9 | 2.4034772237737E9 | 0.10043015448628909 | -0.17544463789319698 | ||||||||||
| P01027 | Complement C3 [OS=Mus musculus] | 388.541 | cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular;other cell component | signal transduction activity or receptor binding;enzyme regulator activity | 12266 | ENSMUSG00000024164 | C3 | mmu:12266; P01027; Q61370; Q80XP1 | Complement activation, classical pathway; Tyrobp causal network in microglia; Comprehensive IL-17A signaling | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade; Neutrophil degranulation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; G alpha (i) signalling events; Peptide ligand-binding receptors; Alternative complement activation; Activation of C3 and C5 | 0.729783028721347 | 0.712660037675161 | 3269916.660849947 | 1.6657146132333001E7 | 4.4549110086954266E7 | 2.348815473163776 | 3.7680708408856756 | |||||||
| Cont_Q7SIH1 | Alpha-2-macroglobulin OS=Bos taurus OX=9913 GN=A2M PE=1 SV=2 | 370.864 | non-structural extracellular | enzyme regulator activity;other molecular function | 513856 | ENSBTAG00000018137 | A2M | A8E647; bta:513856; Q7SIH1 | IL-6 signaling pathway | 0.839052280267302 | 0.688450665125024 | 5.423624331449187E7 | 7.564994624258716E7 | 7.018676700369896E7 | 0.48008180391196364 | 0.37194179744919537 | |||||||||
| Cont_Q29443 | Serotransferrin OS=Bos taurus OX=9913 GN=TF PE=2 SV=1 | 343.183 | stress response;transport;other biological processes | non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle | other molecular function | 280705 | TF | bta:280705; Q0IIK2; Q29443 | 0.964709887217926 | 0.615274986253429 | 1.48932090998098E8 | 2.32106703986673E8 | 1.5606409762411097E8 | 0.6401335422147162 | 0.06748403432742182 | ||||||||||
| Cont_P07589 | Fibronectin OS=Bos taurus OX=9913 GN=FN1 PE=1 SV=4 | 337.517 | cell adhesion;cell organization and biogenesis;stress response;developmental processes;other biological processes | non-structural extracellular | signal transduction activity or receptor binding;other molecular function | FN1 | P07589 | 0.525827426782658 | 0.714071857030863 | 166255.75410196633 | 835883.8306505851 | 952169.9232567847 | 2.329898180493011 | 2.5178147853003274 | |||||||||||
| Q80X90 | Filamin-B [OS=Mus musculus] | 335.882 | cell organization and biogenesis;stress response;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 286940 | ENSMUSG00000025278 | Flnb | E9QNV9; mmu:286940; Q80X90; Q8VHX4; Q8VHX7; Q99KY3 | ISG15 antiviral mechanism | 0.238365792894698 | 0.296944306247309 | 154624.23024854946 | 2351112.5534752235 | 6048828.490809467 | 3.926505287666639 | 5.289817436625841 | ||||||||
| Cont_P35527 | Keratin, type I cytoskeletal 9 OS=Homo sapiens OX=9606 GN=KRT9 PE=1 SV=3 | 310.424 | cell organization and biogenesis;other biological processes | cytosol;cytoskeleton | cytoskeletal activity | 3857 | ENSG00000171403 | KRT9 | hsa:3857; O00109; P35527; Q0IJ47; Q14665 | Formation of the cornified envelope | 0.73072258897653 | 0.836660982916281 | 2.9224080803851068E7 | 3.250630567014273E7 | 4.1318104811136335E7 | 0.1535619557424608 | 0.4996164340004211 | ||||||||
| Cont_P04264 | Keratin, type II cytoskeletal 1 OS=Homo sapiens OX=9606 GN=KRT1 PE=1 SV=6 | 306.58 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;other molecular function | 3848 | ENSG00000167768 | KRT1 | B2RA01; hsa:3848; P04264; P85925; P86104; Q14720; Q6GSJ0; Q9H298 | Corticotropin-releasing hormone signaling | Formation of the cornified envelope; Neutrophil degranulation; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.653826967689551 | 0.65780924735352 | 1.5397854514739665E8 | 1.3414412508194733E8 | 1.6528138436319932E8 | -0.1989454723145774 | 0.10219489843707631 | |||||||
| P06909 | Complement factor H [OS=Mus musculus] | 292.01 | cell adhesion;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes | non-structural extracellular;plasma membrane;other membranes;mitochondrion;other cell component | other molecular function | 12628 | ENSMUSG00000026365 | Cfh | mmu:12628; P06909; Q6NZK3 | Regulation of Complement cascade | 0.0359547312524068 | 0.205200089226065 | 59542.32714759521 | 1.0566840244224759E7 | 1.036081717107911E7 | 7.471412714259086 | 7.443006470545328 | ||||||||
| P16546 | Spectrin alpha chain, non-erythrocytic 1 [OS=Mus musculus] | 291.854 | cell organization and biogenesis | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 20740 | ENSMUSG00000057738 | Sptan1 | A3KGU6; A3KGU8; P16546; Q8K380; Q9CT05 | FAS pathway and stress induction of HSP regulation | Neutrophil degranulation; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Interaction between L1 and Ankyrins; COPI-mediated anterograde transport; RHOU GTPase cycle; RHOV GTPase cycle; Caspase-mediated cleavage of cytoskeletal proteins | 0.786160319109602 | 0.958962194559628 | 684626.7741473566 | 1427277.73205798 | 3976922.979229001 | 1.0598764752393854 | 2.5382630028634425 | |||||||
| Cont_P13645 | Keratin, type I cytoskeletal 10 OS=Homo sapiens OX=9606 GN=KRT10 PE=1 SV=6 | 286.713 | cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes | plasma membrane;cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;other molecular function | 3858 | ENSG00000186395 | KRT10 | hsa:3858; P13645; Q14664; Q8N175 | Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.490821286240141 | 0.600890052902075 | 1.1091978559495355E8 | 9.409796786421584E7 | 1.13950700113199E8 | -0.23728126077989872 | 0.0388930557490876 | ||||||||
| Cont_P35908 | Keratin, type II cytoskeletal 2 epidermal OS=Homo sapiens OX=9606 GN=KRT2 PE=1 SV=2 | 284.975 | cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes | plasma membrane;cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;cytoskeletal activity | 3849 | ENSG00000172867 | KRT2 | hsa:3849; P35908; Q4VAQ2 | Formation of the cornified envelope | 0.411258958244596 | 0.499413631103761 | 4.776750778997586E7 | 2.9357809740500167E7 | 3.415287514761583E7 | -0.702285269017387 | -0.4840225715664078 | ||||||||
| Q62059 | Versican core protein [OS=Mus musculus] | 279.715 | cell adhesion;developmental processes | non-structural extracellular;extracellular matrix;other cell component | other molecular function | Vcan | Q62058; Q62059; Q9CUU0 | ECM proteoglycans; Glycosaminoglycan-protein linkage region biosynthesis; CS/DS degradation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; CS-GAG biosynthesis; DS-GAG biosynthesis | 1.8644578313253E-17 | 1.65082956259427E-17 | 104188.56292801573 | 9.037034497028168E7 | 9.467651077277745E7 | 9.760508702070462 | 9.827665809842685 | ||||||||||
| P10493 | Nidogen-1 [OS=Mus musculus] | 275.191 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | other molecular function | 18073 | ENSMUSG00000005397 | Nid1 | mmu:18073; P10493; Q3TKX9; Q8BQI3; Q8C3U8; Q8C9P6 | Laminin interactions; Degradation of the extracellular matrix | 1.8644578313253E-17 | 1.65082956259427E-17 | 322455.2944414853 | 1.2120394496125467E8 | 1.2671518083095133E8 | 8.554121783692475 | 8.618274500807305 | ||||||||
| O88207 | Collagen alpha-1(V) chain [OS=Mus musculus] | 275.025 | cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes | extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12831 | ENSMUSG00000026837 | Col5a1 | A3KGE3; mmu:12831; O88207; Q3UG94; Q6F6B0 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | ECM proteoglycans; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; MET activates PTK2 signaling | 1.8644578313253E-17 | 1.65082956259427E-17 | 80388.83753211687 | 3577832.3612721 | 8562033.320911517 | 5.475946792986802 | 6.734814451334498 | |||||||
| P37889 | Fibulin-2 [OS=Mus musculus] | 269.894 | other biological processes | non-structural extracellular | other molecular function | 14115 | ENSMUSG00000064080 | Fbln2 | G5E8B3; mmu:14115; P37889; Q9WUI2 | Molecules associated with elastic fibres | 0.0640195441309023 | 1.65082956259427E-17 | 362692.0010392267 | 6.556805587417743E7 | 8.021475911820169E7 | 7.498104380777058 | 7.78897897175684 | ||||||||
| Q8VHX6 | Filamin-C [OS=Mus musculus] | 249.498 | cell organization and biogenesis;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity | 68794 | ENSMUSG00000068699 | Flnc | B2RY80; B9EKT2; mmu:68794; Q6PAI6; Q8VHX6; Q9JJ38 | Cell-extracellular matrix interactions | 0.719627996749639 | 0.562594032195739 | 406087.97266412666 | 1016453.1391661359 | 2089599.8263247435 | 1.3236795012500113 | 2.3633624781914326 | ||||||||
| Q04857 | Collagen alpha-1(VI) chain [OS=Mus musculus] | 248.981 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component | other molecular function | 12833 | ENSMUSG00000001119 | Col6a1 | mmu:12833; Q04857 | ECM proteoglycans; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Signaling by PDGF; NCAM1 interactions | 0.392208211277376 | 0.2534363617947 | 76865.2077476112 | 5.0068940213435836E7 | 6.914260176814564E7 | 9.34736947879783 | 9.813028451743143 | ||||||||
| Cont_Q2UVX4 | Complement C3 OS=Bos taurus OX=9913 GN=C3 PE=1 SV=2 | 247.154 | cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular;other cell component | signal transduction activity or receptor binding;enzyme regulator activity | 280677 | ENSBTAG00000017280 | C3 | bta:280677; Q2KIZ4; Q2UVX4 | Complement and coagulation cascades; Complement activation, classical pathway | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Neutrophil degranulation; Peptide ligand-binding receptors; G alpha (i) signalling events; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade; Alternative complement activation; Activation of C3 and C5 | 0.798729234704005 | 0.615680953989958 | 1.4686759191254234E7 | 1.84550126489547E7 | 1.5291804049274266E7 | 0.329496643269344 | 0.058242535434261965 | |||||||
| Q62261 | Spectrin beta chain, non-erythrocytic 1 [OS=Mus musculus] | 244.684 | cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 20742 | ENSMUSG00000020315 | Sptbn1 | A2AFU1; mmu:20742; Q3TEM7; Q5SQL8; Q5SQL9; Q62261; Q9QWJ7 | COPI-mediated anterograde transport; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; RHOU GTPase cycle; Interaction between L1 and Ankyrins; RHOV GTPase cycle | 0.776437620310661 | 0.69394578118832 | 492454.03878621367 | 920886.7046363313 | 2921004.358024217 | 0.9030345918205293 | 2.568403522778103 | ||||||||
| Q640N1 | Adipocyte enhancer-binding protein 1 [OS=Mus musculus] | 239.707 | protein metabolism;other biological processes | nucleus;other cell component | nucleic acid binding activity;other molecular function | 11568 | ENSMUSG00000020473 | Aebp1 | mmu:11568; O88442; Q3TVV5; Q3TWA7; Q3TX56; Q3TXB2; Q5NCI9; Q61281; Q640N1 | 0.0457359864845759 | 0.269326617826563 | 4843934.666021533 | 3.9556778473622136E7 | 4.1143769603117764E7 | 3.029673625475387 | 3.0864226685149996 | |||||||||
| P57780 | Alpha-actinin-4 [OS=Mus musculus] | 239.42 | cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes | cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 60595 | ENSMUSG00000054808 | Actn4 | mmu:60595; P57780 | Primary focal segmental glomerulosclerosis (FSGS) | Platelet degranulation | 1.8644578313253E-17 | 1.65082956259427E-17 | 20900.169415734228 | 4580996.01302682 | 9830280.285985528 | 7.7760028602441835 | 8.877574105018988 | |||||||
| Q7TPR4 | Alpha-actinin-1 [OS=Mus musculus] | 235.529 | cell adhesion;cell organization and biogenesis;other biological processes | plasma membrane;other membranes;cytoskeleton;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function | 109711 | ENSMUSG00000015143 | Actn1 | mmu:109711; Q7TPR4 | Regulation of actin cytoskeleton; Integrin-mediated cell adhesion; Focal adhesion | Platelet degranulation ; RHOF GTPase cycle; RHOBTB2 GTPase cycle; RHOD GTPase cycle; Regulation of cytoskeletal remodeling and cell spreading by IPP complex components | 0.178726136005694 | 0.995554138371554 | 486802.1989182571 | 2525588.7379033365 | 6210475.170240924 | 2.3752121425876065 | 3.673296064913109 | |||||||
| P02468 | Laminin subunit gamma-1 [OS=Mus musculus] | 230.882 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | Lamc1 | P02468 | 0.116315527815218 | 0.118212047511996 | 18104.5719498812 | 7327169.184632126 | 1.61740059690847E7 | 8.660758050441677 | 9.803107266380897 | |||||||||||
| Q91ZX7 | Prolow-density lipoprotein receptor-related protein 1 [OS=Mus musculus] | 230.497 | other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;other molecular function | 16971 | Lrp1 | mmu:16971; Q61291; Q91ZX7; Q920Y4 | Statin pathway; Wnt signaling pathway | Scavenging of heme from plasma; Retinoid metabolism and transport | 0.0181625429641231 | 1.65082956259427E-17 | 30670.78727387535 | 3548407.5296101067 | 7355877.025944923 | 6.854162701489687 | 7.9058883521099 | ||||||||
| Cont_P60712 | Actin, cytoplasmic 1 OS=Bos taurus OX=9913 GN=ACTB PE=1 SV=1 | 225.45 | cell organization and biogenesis;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component | enzyme regulator activity;cytoskeletal activity;other molecular function | 100033878; 100135470; 100173832; 101844587; 102139853; 11461; 118833809; 280979; 396526; 403580; 414396; 443052; 450133; 60; 81822 | ENSBTAG00000026199; ENSCAFG00000016020; ENSCAFG00030015381; ENSCAFG00040015695; ENSCPOG00000013467; ENSG00000075624; ENSMAUG00000008763; ENSMUSG00000029580; ENSOARG00040012985; ENSOARG00180022443; ENSOARG00185023855; ENSOARG00215030140; ENSOARG00225009314; ENSPPYG00000017336; ENSPTRG00000018890; ENSRNOG00000034254; ENSSSCG00000007585; ENSSSCG00030003451; ENSSSCG00035038792; ENSSSCG00040049462; ENSSSCG00045027458; ENSSSCG00050065025; ENSSSCG00055012597; ENSSSCG00060019124; ENSSSCG00065037921; ENSSSCG00070011353; ENSSSCG00105030144; ENSSSCG00110026965; ENSSSCG00115013637; ENSSSCG00130033784 | Actb; ACTB | A5D961; A5PKA1; bta:280979; cfa:403580; cpoc:100135470; csab:103246953; ecb:100033878; gga:396526; hsa:60; maua:101844587; mmu:11461; O18840; oas:443052; P02570; P60706; P60707; P60708; P60709; P60710; P60711; P60712; P60713; P70514; P99021; pon:100173832; ptr:450133; Q11209; Q11211; Q3SZD2; Q3TI89; Q3TVP6; Q4L0Y2; Q4R561; Q5R1X3; Q5R582; Q5R6G0; Q64316; Q6QAQ1; Q6ZWM3; Q711N9; Q71FK5; Q75MN2; Q76N69; Q8MIJ0; Q8SPX4; Q95164; Q96B34; Q96HG5; rno:81822; ssc:414396 | FAS pathway and stress induction of HSP regulation; Actin cytoskeleton regulation; Myometrial relaxation and contraction pathways; Focal adhesion; Arrhythmogenic right ventricular cardiomyopathy; Pathogenic Escherichia coli infection; Common pathways underlying drug addiction; Myometrial relaxation and contraction pathways; Focal adhesion; Fas ligand pathway and stress induction of heat shock proteins; Pathogenic Escherichia coli infection; Arrhythmogenic right ventricular cardiomyopathy; Focal adhesion; Myometrial relaxation and contraction pathways; Regulation of actin cytoskeleton; Myometrial relaxation and contraction pathways; Ebola virus infection in host; Acute viral myocarditis; Thermogenesis; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Overlap between signal transduction pathways contributing to LMNA laminopathies; Pleural mesothelioma; Regulation of actin cytoskeleton; Network map of SARS-CoV-2 signaling; Regulation of actin cytoskeleton; Regulation of actin cytoskeleton; Focal adhesion | Formation of the canonical BAF (cBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); Regulation of actin dynamics for phagocytic cup formation; EPH-ephrin mediated repulsion of cells; Formation of annular gap junctions; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; RHO GTPases Activate Formins; RHOF GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; B-WICH complex positively regulates rRNA expression; Regulation of CDH1 Function; Formation of the dystrophin-glycoprotein complex (DGC); Formation of the canonical BAF (cBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); RHO GTPases Activate WASPs and WAVEs; UCH proteinases; DNA Damage Recognition in GG-NER; Formation of the non-canonical BAF (ncBAF) complex; RHO GTPases activate IQGAPs; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Cell-extracellular matrix interactions; MAP2K and MAPK activation; Interaction between L1 and Ankyrins; RHOF GTPase cycle; DNA Damage Recognition in GG-NER; MAP2K and MAPK activation; RHO GTPases Activate Formins; Clathrin-mediated endocytosis; UCH proteinases; RHOF GTPase cycle; DNA Damage Recognition in GG-NER; EPH-ephrin mediated repulsion of cells; VEGFA-VEGFR2 Pathway; Regulation of actin dynamics for phagocytic cup formation; Adherens junctions interactions; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); RHO GTPases Activate WASPs and WAVEs; B-WICH complex positively regulates rRNA expression; Regulation of CDH1 Function; EPHB-mediated forward signaling; Formation of the non-canonical BAF (ncBAF) complex; Formation of the canonical BAF (cBAF) complex; Formation of annular gap junctions; RHO GTPases activate IQGAPs; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; RHO GTPases Activate WASPs and WAVEs; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RHO GTPases activate IQGAPs; RHO GTPases Activate Formins; RHOF GTPase cycle; Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs); B-WICH complex positively regulates rRNA expression; Signaling by BRAF and RAF1 fusions; UCH proteinases; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; VEGFA-VEGFR2 Pathway; Formation of the dystrophin-glycoprotein complex (DGC); Factors involved in megakaryocyte development and platelet production; Regulation of MITF-M-dependent genes involved in pigmentation; Formation of the canonical BAF (cBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); EPH-ephrin mediated repulsion of cells; HATs acetylate histones; Interaction between L1 and Ankyrins; Prefoldin mediated transfer of substrate to CCT/TriC; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Adherens junctions interactions; Regulation of CDH1 Function; Formation of the non-canonical BAF (ncBAF) complex; DNA Damage Recognition in GG-NER; Formation of the polybromo-BAF (pBAF) complex; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Formation of annular gap junctions; Folding of actin by CCT/TriC; Cell-extracellular matrix interactions; MAP2K and MAPK activation; RHO GTPases Activate Formins; Recycling pathway of L1; RHO GTPases activate IQGAPs; Clathrin-mediated endocytosis; Formation of the dystrophin-glycoprotein complex (DGC); EPHB-mediated forward signaling; UCH proteinases; B-WICH complex positively regulates rRNA expression; Adherens junctions interactions; Formation of the non-canonical BAF (ncBAF) complex; Formation of annular gap junctions; Formation of the polybromo-BAF (pBAF) complex; VEGFA-VEGFR2 Pathway; Cell-extracellular matrix interactions; RHO GTPases Activate WASPs and WAVEs; Regulation of CDH1 Function; Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; UCH proteinases; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); Formation of the polybromo-BAF (pBAF) complex; B-WICH complex positively regulates rRNA expression; DNA Damage Recognition in GG-NER; Formation of the canonical BAF (cBAF) complex; RHO GTPases Activate Formins; Regulation of CDH1 Function; Interaction between L1 and Ankyrins; RHOF GTPase cycle; Formation of the non-canonical BAF (ncBAF) complex; Adherens junctions interactions; Formation of the dystrophin-glycoprotein complex (DGC); VEGFA-VEGFR2 Pathway; RHO GTPases Activate WASPs and WAVEs; Cell-extracellular matrix interactions; EPHB-mediated forward signaling; MAP2K and MAPK activation; Recycling pathway of L1; RHO GTPases activate IQGAPs; Formation of annular gap junctions; B-WICH complex positively regulates rRNA expression; UCH proteinases; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); MAP2K and MAPK activation; Formation of the polybromo-BAF (pBAF) complex; RHO GTPases Activate Formins; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases Activate WASPs and WAVEs; Formation of the dystrophin-glycoprotein complex (DGC); VEGFA-VEGFR2 Pathway; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; DNA Damage Recognition in GG-NER; RHOF GTPase cycle; Cell-extracellular matrix interactions; Adherens junctions interactions; Formation of the non-canonical BAF (ncBAF) complex; Formation of the canonical BAF (cBAF) complex; RHO GTPases activate IQGAPs; Regulation of CDH1 Function; Gap junction degradation; Formation of annular gap junctions; Regulation of actin dynamics for phagocytic cup formation; RHOF GTPase cycle; Clathrin-mediated endocytosis; RHO GTPases Activate Formins; Cell-extracellular matrix interactions; VEGFA-VEGFR2 Pathway; Adherens junctions interactions; RHO GTPases activate IQGAPs; UCH proteinases; EPHB-mediated forward signaling; MAP2K and MAPK activation; RHO GTPases Activate WASPs and WAVEs; Formation of the dystrophin-glycoprotein complex (DGC); Formation of annular gap junctions; Formation of the canonical BAF (cBAF) complex; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of the non-canonical BAF (ncBAF) complex; Regulation of CDH1 Function | 1.8644578313253E-17 | 1.65082956259427E-17 | 1996659.4544256767 | 4.828873920581084E7 | 6.5074451419171505E7 | 4.596026599796858 | 5.0264310485118315 | |||||||
| P63260 | Actin, cytoplasmic 2 [OS=Mus musculus] | 217.791 | cell organization and biogenesis;stress response;developmental processes;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 11465 | ENSMUSG00000062825 | Actg1 | mmu:11465; P02571; P14104; P63260; P99022 | Myometrial relaxation and contraction pathways; Regulation of actin cytoskeleton; Focal adhesion | Platelet degranulation ; RHO GTPases activate IQGAPs; Adherens junctions interactions; Regulation of CDH1 Function; RHO GTPases Activate Formins; Regulation of actin dynamics for phagocytic cup formation; Interaction between L1 and Ankyrins; MAP2K and MAPK activation; Recycling pathway of L1; Clathrin-mediated endocytosis; Formation of the dystrophin-glycoprotein complex (DGC); EPHB-mediated forward signaling; RHOF GTPase cycle; Formation of annular gap junctions; VEGFA-VEGFR2 Pathway; Cell-extracellular matrix interactions; RHO GTPases Activate WASPs and WAVEs; RHOBTB2 GTPase cycle | 1.8644578313253E-17 | 1.65082956259427E-17 | 145698.54484736864 | 254666.434448248 | ||||||||||
| P33434 | 72 kDa type IV collagenase [OS=Mus musculus] | 212.03 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes | extracellular matrix;plasma membrane;other membranes;cytoskeleton;mitochondrion;nucleus;other cell component | other molecular function | 17390 | ENSMUSG00000031740 | Mmp2 | mmu:17390; P33434 | Lung fibrosis; IL-3 signaling pathway; Matrix metalloproteinases | Collagen degradation; Extra-nuclear estrogen signaling; EPH-ephrin mediated repulsion of cells; Activation of Matrix Metalloproteinases | 0.964209443670126 | 0.372996577396536 | 2.5908623508144036E7 | 2.11513119484971E7 | 6.116415043649567E7 | -0.292685217123521 | 1.239253938445554 | |||||||
| P19096 | Fatty acid synthase [OS=Mus musculus] | 203.372 | other metabolic processes;stress response;other biological processes | plasma membrane;other membranes;cytosol;ER/Golgi;other cell component | other molecular function | 14104 | ENSMUSG00000025153 | Fasn | B1ATU8; mmu:14104; P19096; Q6PB72; Q8C4Z0; Q9EQR0 | Fatty acid biosynthesis; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-9 fatty acid synthesis; Elongation of (very) long chain fatty acids | Fatty acyl-CoA biosynthesis; Vitamin B5 (pantothenate) metabolism | 0.847457711018997 | 0.66189768147619 | 102793.32580216101 | 1389784.0897720233 | 2729524.669883373 | 3.757042269214309 | 4.730831235531711 | |||||||
| Cont_Q3SZ57 | Alpha-fetoprotein OS=Bos taurus OX=9913 GN=AFP PE=2 SV=1 | 202.89 | other metabolic processes;developmental processes;other biological processes | non-structural extracellular;other cell component | other molecular function | 506011 | ENSBTAG00000017131 | AFP | bta:506011; Q3SZ57 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 0.82964085881652 | 0.540832988168188 | 3.8603879197485335E7 | 4.5317948160280704E7 | 3.6151020512819335E7 | 0.23133671517440235 | -0.09470945341303746 | ||||||||
| P48678 | Prelamin-A/C [OS=Mus musculus] | 202.607 | cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes | other membranes;cytoskeleton;nucleus;other cell component | other molecular function | 16905 | ENSMUSG00000028063 | Lmna | B3RH23; B3RH24; mmu:16905; P11516; P48678; P97859; Q3TIH0; Q3TTS8; Q3U733; Q3U7I5; Q3UCA0; Q3UCJ8; Q3UCU3; Q91WF2; Q9DC21 | Adipogenesis genes; FAS pathway and stress induction of HSP regulation | 0.00670345592293191 | 1.65082956259427E-17 | 75722.11050192213 | 4134986.871037207 | 1.1058985470826533E7 | 5.771024316562613 | 7.190288704425306 | ||||||||
| Q02788 | Collagen alpha-2(VI) chain [OS=Mus musculus] | 202.37 | cell adhesion;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component | other molecular function | 12834 | ENSMUSG00000020241 | Col6a2 | mmu:12834; Q02788; Q05505; Q8C972; Q8K229 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | ECM proteoglycans; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation | 1.8644578313253E-17 | 0.175734701097799 | 121237.29953889274 | 4.136492509189963E7 | 5.21291258166705E7 | 8.414430536592976 | 8.748112233779976 | |||||||
| P97927 | Laminin subunit alpha-4 [OS=Mus musculus] | 199.33 | cell adhesion;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | signal transduction activity or receptor binding | 16775 | ENSMUSG00000019846 | Lama4 | mmu:16775; O88785; P70409; P97927; Q14BF2 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Formation of the dystrophin-glycoprotein complex (DGC); Laminin interactions; MET activates PTK2 signaling | 0.645007535999596 | 0.496649188935323 | 390078.69973194966 | 5125646.74812024 | 1.037511250312096E7 | 3.715896926492177 | 4.733217948190459 | |||||||
| P20152 | Vimentin [OS=Mus musculus] | 183.446 | cell organization and biogenesis;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component | cytoskeletal activity;nucleic acid binding activity;other molecular function | 22352 | ENSMUSG00000026728 | Vim | mmu:22352; O08704; P20152; Q8CCH1 | Spinal cord injury; Primary focal segmental glomerulosclerosis (FSGS); Alpha 6 beta 4 integrin signaling pathway | Aggrephagy; Striated Muscle Contraction; Caspase-mediated cleavage of cytoskeletal proteins; RHOBTB1 GTPase cycle | 0.0955146622024883 | 1.65082956259427E-17 | 1112472.104030337 | 7365249.698992513 | 3.3401280645601466E7 | 2.7269652767818724 | 4.908062353318758 | |||||||
| Q64727 | Vinculin [OS=Mus musculus] | 182.753 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | plasma membrane;other membranes;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 22330 | ENSMUSG00000021823 | Vcl | mmu:22330; Q64727; Q8BP32; Q8BS46; Q922C5; Q922D9 | Primary focal segmental glomerulosclerosis (FSGS); IL-3 signaling pathway; Regulation of actin cytoskeleton; Integrin-mediated cell adhesion; Focal adhesion | Neutrophil degranulation; High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells; Platelet degranulation ; MAP2K and MAPK activation; Smooth Muscle Contraction; Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells; Regulation of CDH1 Function | 0.190838415616571 | 0.208404050858596 | 126150.06188907423 | 1953982.7579073233 | 4840837.086136207 | 3.9532049177000044 | 5.262043723246207 | |||||||
| Q8K4G1 | Latent-transforming growth factor beta-binding protein 4 [OS=Mus musculus] | 180.216 | cell-cell signaling;cell organization and biogenesis;transport;signal transduction | non-structural extracellular;extracellular matrix | other molecular function | 108075 | ENSMUSG00000040488 | Ltbp4 | E9QPD9; mmu:108075; Q8K4G0; Q8K4G1 | TGF-beta receptor signaling activates SMADs; Molecules associated with elastic fibres | 0.362779483059131 | 0.308350896322176 | 50068.58855747415 | 1469976.6770863 | 2473680.681365607 | 4.875743668797631 | 5.626609683578324 | ||||||||
| Q68FD5 | Clathrin heavy chain 1 [OS=Mus musculus] | 180.117 | cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes | plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component | nucleic acid binding activity;other molecular function | 67300 | ENSMUSG00000047126 | Cltc | mmu:67300; Q68FD5 | IL-7 signaling pathway; Kit receptor signaling pathway | MHC class II antigen presentation; Recycling pathway of L1; Cargo recognition for clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis; LDL clearance; Retrograde neurotrophin signalling; Formation of annular gap junctions; Lysosome Vesicle Biogenesis; WNT5A-dependent internalization of FZD4; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation; RHOU GTPase cycle; RHOV GTPase cycle | 0.198232028950426 | 0.4248536990637 | 14581.209031729499 | 1426606.2225329466 | 2101059.0869428 | 6.612333012441563 | 7.170862575755155 | |||||||
| P02469 | Laminin subunit beta-1 [OS=Mus musculus] | 179.863 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;nucleus;other cell component | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 16777 | ENSMUSG00000002900 | Lamb1 | E9PXZ9; P02469 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Inflammatory response pathway; Alpha 6 beta 4 integrin signaling pathway; Focal adhesion | 0.341417478664423 | 0.205801242418232 | 1.0460538665187027E7 | 1.4326337702720901E7 | 1.8407714250900764E7 | 0.45371270995740953 | 0.8153533483670897 | ||||||||
| Q01853 | Transitional endoplasmic reticulum ATPase [OS=Mus musculus] | 179.055 | cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;other biological processes | other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;enzyme regulator activity;other molecular function | 269523 | ENSMUSG00000028452 | Vcp | mmu:269523; Q01853; Q3TFH9; Q3TIM2; Q3TXN9; Q6PI18; Q8BSR6; Q8CEG4 | IL-9 signaling pathway | RHOH GTPase cycle; Neutrophil degranulation; Protein methylation; Ovarian tumor domain proteases; Neddylation; ABC-family proteins mediated transport; Translesion Synthesis by POLH; Hedgehog ligand biogenesis; KEAP1-NFE2L2 pathway; HSF1 activation; N-glycan trimming in the ER and Calnexin/Calreticulin cycle; Josephin domain DUBs | 0.645007535999596 | 0.915230778358139 | 621808.5300221853 | 5338414.413398174 | 9329554.935730066 | 3.101868991218387 | 3.9072659463434927 | |||||||
| Q03350 | Thrombospondin-2 [OS=Mus musculus] | 178.303 | cell adhesion;other biological processes | non-structural extracellular;extracellular matrix;other cell component | other molecular function | 21826 | ENSMUSG00000023885 | Thbs2 | mmu:21826; Q03350; Q8CG21 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Signaling by PDGF; O-glycosylation of TSR domain-containing proteins | 0.861805134687803 | 0.425958502904743 | 1929828.2171104867 | 7439397.130180354 | 1.1102887711296873E7 | 1.9467132814492152 | 2.524390613497798 | |||||||
| Q80YX1 | Tenascin [OS=Mus musculus] | 175.9 | cell adhesion;cell-cell signaling;cell organization and biogenesis;stress response;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | signal transduction activity or receptor binding;other molecular function | 21923 | ENSMUSG00000028364 | Tnc | mmu:21923; Q64706; Q80YX1; Q80YX2 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Integrin cell surface interactions; ECM proteoglycans; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 0.827773046590747 | 0.117980756369098 | 20862.416559578665 | 1449614.4281484466 | 1.2106484504902953E7 | 6.118619130163546 | 9.18065799957951 | |||||||
| Q61147 | Ceruloplasmin [OS=Mus musculus] | 175.43 | cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular | other molecular function | 12870 | ENSMUSG00000003617 | Cp | mmu:12870; Q61147; Q6P5C8 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Iron uptake and transport; Metal ion SLC transporters | 0.0286042496128814 | 1.65082956259427E-17 | 116072.0240394514 | 4703216.257241024 | 9598922.193485493 | 5.340555472510453 | 6.369780225828648 | ||||||||
| Q3UQ28 | Peroxidasin homolog [OS=Mus musculus] | 173.636 | cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes | extracellular matrix;ER/Golgi;other cell component | extracellular structural activity;other molecular function | 69675 | ENSMUSG00000020674 | Pxdn | A4FU83; E9QNQ9; mmu:69675; Q3UQ28 | Crosslinking of collagen fibrils | 0.199060935853007 | 0.121749369203589 | 52188.79804577449 | 3468268.863888983 | 1.0141728842991263E7 | 6.054331756125822 | 7.602347715901429 | ||||||||
| Q61316 | Heat shock 70 kDa protein 4 [OS=Mus musculus] | 169.044 | protein metabolism;other metabolic processes | other cell component | other molecular function | Hspa4 | Q61316 | Regulation of HSF1-mediated heat shock response | 0.947627746595709 | 0.675982462193546 | 51496.56273693644 | 1715523.4149199834 | 3885769.0116153997 | 5.058028867603881 | 6.2375801933412385 | ||||||||||
| Cont_P02533 | Keratin, type I cytoskeletal 14 OS=Homo sapiens OX=9606 GN=KRT14 PE=1 SV=4 | 164.831 | cell organization and biogenesis;other biological processes | plasma membrane;cytosol;cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 3861 | ENSG00000186847 | KRT14 | hsa:3861; P02533; Q14715; Q53XY3; Q9BUE3; Q9UBN2; Q9UBN3; Q9UCY4 | Corticotropin-releasing hormone signaling | Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin; Developmental Lineage of Mammary Gland Myoepithelial Cells; Type I hemidesmosome assembly | 0.880930298968675 | 0.821333803243143 | 6829492.454091667 | 1.0299655985485494E7 | 9892865.41378706 | 0.5927458802001806 | 0.5346100841122959 | |||||||
| P11499 | Heat shock protein HSP 90-beta [OS=Mus musculus] | 164.719 | cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component | enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function | 15516 | ENSMUSG00000023944 | Hsp90ab1 | mmu:15516; O89078; P11499; Q3UIQ7 | Focal adhesion: PI3K-Akt-mTOR signaling pathway | Neutrophil degranulation; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of actin dynamics for phagocytic cup formation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Attenuation phase; Estrogen-dependent gene expression; Sema3A PAK dependent Axon repulsion; Aryl hydrocarbon receptor signalling; DDX58/IFIH1-mediated induction of interferon-alpha/beta; HSF1 activation; RHOBTB2 GTPase cycle; The NLRP3 inflammasome | 1.8644578313253E-17 | 1.65082956259427E-17 | 166033.98771248801 | 1.0807613687705928E7 | 3.193268303009924E7 | 6.024425605817814 | 7.587411368791836 | |||||||
| Q9JKF1 | Ras GTPase-activating-like protein IQGAP1 [OS=Mus musculus] | 163.926 | cell organization and biogenesis;developmental processes;signal transduction;other biological processes | plasma membrane;other membranes;cytoskeleton;nucleus;other cell component | enzyme regulator activity;other molecular function | 29875 | ENSMUSG00000030536 | Iqgap1 | G3UW45; mmu:29875; Q9JKF1 | G13 signaling pathway; Regulation of actin cytoskeleton | RHO GTPases activate IQGAPs; Neutrophil degranulation; RAC1 GTPase cycle; RAC2 GTPase cycle; RHOA GTPase cycle; MAP2K and MAPK activation; RHOQ GTPase cycle; RHOC GTPase cycle; RHOU GTPase cycle; RHOV GTPase cycle; Nephrin family interactions | 0.794460986683881 | 0.930229675308081 | 58984.367745696 | 331165.4406654323 | 1068898.0084058929 | 2.489147563897488 | 4.1796477342414615 | |||||||
| P52480 | Pyruvate kinase PKM [OS=Mus musculus] | 163.393 | cell organization and biogenesis;other metabolic processes;other biological processes | cytosol;ER/Golgi;nucleus;other cell component | nucleic acid binding activity;kinase activity;other molecular function | 18746 | ENSMUSG00000032294 | Pkm | mmu:18746; P52480; Q3TBV8; Q3TBW5; Q3TC59; Q3U1X3; Q3U5P6; Q4VC20; Q64484; Q91YI8; Q9CWB1 | Glycolysis and gluconeogenesis; Purine metabolism | Neutrophil degranulation; Pyruvate metabolism; Glycolysis; Regulation of pyruvate metabolism | 1.8644578313253E-17 | 1.65082956259427E-17 | 224031.9482756436 | 1.1706302394897154E7 | 1.6687028973496003E7 | 5.707437157684907 | 6.218878820280579 | |||||||
| P63017 | Heat shock cognate 71 kDa protein [OS=Mus musculus] | 161.557 | cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component | signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function | 15481 | ENSMUSG00000015656 | Hspa8 | mmu:15481; P08109; P12225; P63017; Q3U6R0; Q3U764; Q3U7D7; Q3U7E2; Q3U9B4; Q3U9G0; Q3UGM0; Q5FWJ6; Q62373; Q62374; Q62375; Q6NZD0 | Mapk signaling pathway; Exercise-induced circadian regulation | Neutrophil degranulation; mRNA Splicing - Major Pathway; Regulation of HSF1-mediated heat shock response; PKR-mediated signaling; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis; Attenuation phase; Lysosome Vesicle Biogenesis; GABA synthesis, release, reuptake and degradation; AUF1 (hnRNP D0) binds and destabilizes mRNA; Protein methylation | 1.8644578313253E-17 | 1.65082956259427E-17 | 232221.67704249235 | 1.5723480869725833E7 | 2.2348098618015703E7 | 6.081274178280651 | 6.588505632754927 | |||||||
| Q9JHU4 | Cytoplasmic dynein 1 heavy chain 1 [OS=Mus musculus] | 161.009 | cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes | cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 13424 | ENSMUSG00000018707 | Dync1h1 | E9QM71; mmu:13424; Q9JHU4 | MHC class II antigen presentation; Neutrophil degranulation; Separation of Sister Chromatids; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; COPI-mediated anterograde transport; Recruitment of NuMA to mitotic centrosomes; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-independent Golgi-to-ER retrograde traffic; Aggrephagy; Anchoring of the basal body to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; AURKA Activation by TPX2 | 0.826895204418257 | 0.591873375996003 | 294620.0253220563 | 451351.8596347517 | 1275535.4534856554 | 0.6153970578330761 | 2.1141756003853147 | ||||||||
| Q99K41 | EMILIN-1 [OS=Mus musculus] | 157.011 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 100952 | ENSMUSG00000029163 | Emilin1 | mmu:100952; Q99K41 | Molecules associated with elastic fibres | 1.8644578313253E-17 | 1.65082956259427E-17 | 1671715.86234765 | 5498413.09956387 | |||||||||||
| Q61879 | Myosin-10 [OS=Mus musculus] | 146 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;nucleic acid binding activity;other molecular function | 77579 | ENSMUSG00000020900 | Myh10 | mmu:77579; Q5SV63; Q61879 | Regulation of actin cytoskeleton | RHO GTPases activate PAKs | 0.506231596289679 | 0.705689538076567 | 123378.89612673952 | 266023.60455562966 | 458865.269073755 | 1.108458619642415 | 1.8949749715174342 | |||||||
| Cont_P00761 | Trypsin OS=Sus scrofa OX=9823 PE=1 SV=1 | 143.502 | protein metabolism;other biological processes | non-structural extracellular | other molecular function | 0.172153475402034 | 0.254996071775817 | 5.863252009900073E9 | 3.334729419178533E9 | 2.1792138371661735E9 | -0.8141313613991668 | -1.4278932978551737 | |||||||||||||
| P20029 | Endoplasmic reticulum chaperone BiP [OS=Mus musculus] | 142.966 | protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component | enzyme regulator activity;translation activity;other molecular function | 14828 | ENSMUSG00000026864 | Hspa5 | mmu:14828; O35642; P20029; Q3UFF2; Q61630 | Mapk signaling pathway | Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Regulation of HSF1-mediated heat shock response | 1.8644578313253E-17 | 1.65082956259427E-17 | 7392689.481756757 | 8222965.927916382 | ||||||||||
| Cont_P13647 | Keratin, type II cytoskeletal 5 OS=Homo sapiens OX=9606 GN=KRT5 PE=1 SV=3 | 142.395 | cell organization and biogenesis;other biological processes | cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;cytoskeletal activity;other molecular function | 3852 | ENSG00000186081 | KRT5 | hsa:3852; P13647; Q6PI71; Q6UBJ0; Q8TA91 | Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin; Developmental Lineage of Mammary Stem Cells; Developmental Lineage of Mammary Gland Myoepithelial Cells; Type I hemidesmosome assembly | 0.847457711018997 | 0.786915923361782 | 5615099.536380176 | 7868513.182470503 | 9974982.226041706 | 0.4867794560282899 | 0.8290026737979193 | ||||||||
| Cont_P08779 | Keratin, type I cytoskeletal 16 OS=Homo sapiens OX=9606 GN=KRT16 PE=1 SV=4 | 140.751 | cell organization and biogenesis;stress response;other biological processes | plasma membrane;cytosol;cytoskeleton | cytoskeletal activity | 3868 | ENSG00000186832 | KRT16 | A8K488; hsa:3868; P08779; P30654; Q16402; Q9UBG8 | Vitamin D receptor pathway | Formation of the cornified envelope | 0.961351301268194 | 0.941324060398065 | 1275668.1444026066 | 3908256.3409277797 | 2249474.51763106 | 1.615272024678325 | 0.8183349524474691 | |||||||
| Cont_P02465 | Collagen alpha-2(I) chain OS=Bos taurus OX=9913 GN=COL1A2 PE=1 SV=2 | 139.99 | non-structural extracellular;extracellular matrix | extracellular structural activity;other molecular function | 282188 | ENSBTAG00000013472 | COL1A2 | A6QP13; bta:282188; O62649; P02465 | Inflammatory response pathway; Focal adhesion | Fibronectin matrix formation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Collagen degradation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; Collagen chain trimerization; GPVI-mediated activation cascade; Platelet Aggregation (Plug Formation); Platelet Adhesion to exposed collagen; GP1b-IX-V activation signalling | 0.876027096029978 | 0.483779141493222 | 70110.45197339094 | 85775.39066064726 | 163731.944383145 | 0.29093425615940965 | 1.223634381101149 | ||||||||
| Cont_P12763 | Alpha-2-HS-glycoprotein OS=Bos taurus OX=9913 GN=AHSG PE=1 SV=2 | 132.772 | stress response;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component | enzyme regulator activity | 280988 | AHSG | A6QLF7; bta:280988; P12763 | Neutrophil degranulation; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 0.793013134473823 | 0.573667790345329 | 6.882384659684638E8 | 8.712402787486216E8 | 6.41500953397899E8 | 0.3401621263323422 | -0.10145711777808486 | |||||||||
| P07901 | Heat shock protein HSP 90-alpha [OS=Mus musculus] | 132.382 | cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component | signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function | 15519 | ENSMUSG00000021270 | Hsp90aa1 | mmu:15519; P07901 | EBV LMP1 signaling; Focal adhesion: PI3K-Akt-mTOR signaling pathway; IL-6 signaling pathway; IL-2 signaling pathway | Regulation of necroptotic cell death; Recruitment of NuMA to mitotic centrosomes; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of actin dynamics for phagocytic cup formation; Neutrophil degranulation; Downregulation of ERBB2 signaling; Anchoring of the basal body to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; AURKA Activation by TPX2; Extra-nuclear estrogen signaling; Attenuation phase; Estrogen-dependent gene expression; Sema3A PAK dependent Axon repulsion; VEGFR2 mediated vascular permeability; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation; DDX58/IFIH1-mediated induction of interferon-alpha/beta; eNOS activation; HSF1 activation; RHOBTB2 GTPase cycle; Drug-mediated inhibition of ERBB2 signaling | 0.508730894200713 | 1.65082956259427E-17 | 138049.65358917884 | 1667357.9717776468 | 3968795.71909318 | 3.594304702710527 | 4.845442133334701 | |||||||
| Q02819 | Nucleobindin-1 [OS=Mus musculus] | 131.152 | signal transduction | non-structural extracellular;other membranes;ER/Golgi | enzyme regulator activity;nucleic acid binding activity;other molecular function | 18220 | ENSMUSG00000030824 | Nucb1 | mmu:18220; Q02819; Q3TU42; Q9CWA1; Q9D8J4; Q9DBL3 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 1.8644578313253E-17 | 1.65082956259427E-17 | 30635.69892492515 | 5493436.34719679 | 1.9240052036173E7 | 7.4863513149475525 | 9.294683220219179 | ||||||||
| Q91V92 | ATP-citrate synthase [OS=Mus musculus] | 129.973 | other metabolic processes | cytosol | other molecular function | 104112 | ENSMUSG00000020917 | Acly | mmu:104112; Q91V92 | Fatty acid biosynthesis | Neutrophil degranulation; Fatty acyl-CoA biosynthesis | 0.371468864113786 | 0.230775890814232 | 27537.414327710998 | 1276919.6113413726 | 2339759.4103227933 | 5.535130791068342 | 6.408823278146731 | |||||||
| A2ASQ1 | Agrin [OS=Mus musculus] | 128.989 | cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cell component | signal transduction activity or receptor binding;other molecular function | 11603 | ENSMUSG00000041936 | Agrn | A2ASP9; A2ASQ0; A2ASQ1; B2RWU1 | Primary focal segmental glomerulosclerosis (FSGS) | ECM proteoglycans; Retinoid metabolism and transport; Glycosaminoglycan-protein linkage region biosynthesis; HS-GAG biosynthesis; HS-GAG degradation; Formation of the dystrophin-glycoprotein complex (DGC) | 1.8644578313253E-17 | 1.65082956259427E-17 | 1695001.2322350666 | 3018900.06344302 | ||||||||||
| Q61508 | Extracellular matrix protein 1 [OS=Mus musculus] | 127.379 | stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular | signal transduction activity or receptor binding;other molecular function | 13601 | ENSMUSG00000028108 | Ecm1 | mmu:13601; Q3U5Q5; Q61508 | Platelet degranulation | 1.8644578313253E-17 | 1.65082956259427E-17 | 74811.39241511819 | 5.132626536679041E7 | 6.196550035866306E7 | 9.422223591696405 | 9.69399151201845 | ||||||||
| Cont_P04259 | Keratin, type II cytoskeletal 6B OS=Homo sapiens OX=9606 GN=KRT6B PE=1 SV=5 | 126.901 | cell organization and biogenesis;other biological processes | cytosol;cytoskeleton | bone, tooth or skin structural activity;cytoskeletal activity | 3854 | ENSG00000185479 | KRT6B | hsa:3854; P04259; P48669 | Formation of the cornified envelope | 0.868132360832926 | 0.857251372850113 | 298970.1410949 | 1156058.5455969477 | 510017.07482617133 | 1.9511411501265994 | 0.7705441417687864 | ||||||||
| P17182 | Alpha-enolase [OS=Mus musculus] | 126.804 | other metabolic processes;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;other cell component | nucleic acid binding activity;other molecular function | 13806; 433182 | ENSMUSG00000059040; ENSMUSG00000063524 | Eno1 | mmu:13806; mmu:433182; P17182; Q99KT7; Q9DCY7 | Glycolysis and gluconeogenesis | 1.8644578313253E-17 | 1.65082956259427E-17 | 47358.53377381337 | 9473047.660860082 | 1.1146559483992001E7 | 7.644060417133689 | 7.878758343175162 | ||||||||
| P08113 | Endoplasmin [OS=Mus musculus] | 126.346 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cell component | signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function | 22027 | ENSMUSG00000020048 | Hsp90b1 | mmu:22027; P08113; P11427 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Hypoxia-dependent self-renewal of myoblasts | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Scavenging by Class A Receptors; Trafficking and processing of endosomal TLR; Interleukin-4 and Interleukin-13 signaling | 0.0104456807471941 | 0.107476768049312 | 52582.03853978356 | 4030450.84914005 | 5006439.15200075 | 6.2602273439427725 | 6.573070961339852 | |||||||
| P58252 | Elongation factor 2 [OS=Mus musculus] | 126.048 | cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;translational apparatus;other cell component | cytoskeletal activity;translation activity;nucleic acid binding activity;other molecular function | 13629 | ENSMUSG00000034994 | Eef2 | mmu:13629; P58252; Q544E4 | Translation factors | Neutrophil degranulation; Protein methylation; Peptide chain elongation; Synthesis of diphthamide-EEF2 | 0.188334321166369 | 0.299809054080284 | 229633.38558146535 | 6414138.274151959 | 1.0566307796994643E7 | 4.8038511446429455 | 5.523995125592705 | |||||||
| Cont_P02538 | Keratin, type II cytoskeletal 6A OS=Homo sapiens OX=9606 GN=KRT6A PE=1 SV=3 | 123.757 | cell organization and biogenesis;stress response;other biological processes | cytosol;cytoskeleton | bone, tooth or skin structural activity;cytoskeletal activity | 3853 | ENSG00000205420 | KRT6A | A4QPC1; hsa:3853; P02538; P48667; Q08AR4; Q6NT67; Q96CL4 | Ectoderm differentiation; Ectoderm differentiation; Pancreatic cancer subtypes | Formation of the cornified envelope | 0.964633336683333 | 0.892533464536408 | 2182876.549653717 | 4785085.111074816 | 3779160.7730984767 | 1.1323140432879846 | 0.7918353525552961 | |||||||
| P97298 | Pigment epithelium-derived factor [OS=Mus musculus] | 123.502 | cell cycle OR cell proliferation;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | enzyme regulator activity | 20317 | ENSMUSG00000000753 | Serpinf1 | mmu:20317; O70629; O88691; P97298 | 0.227296093012204 | 1.65082956259427E-17 | 462579.17347644636 | 1.46490289953418E7 | 7.121805491857927E7 | 4.984960915629733 | 7.266398910121059 | |||||||||
| Q70E20 | Sushi, nidogen and EGF-like domain-containing protein 1 [OS=Mus musculus] | 122.942 | cell adhesion | non-structural extracellular;extracellular matrix | other molecular function | 208777 | Sned1 | A6H6I3; mmu:208777; Q70E20; Q810H2; Q8BMD9 | 1.8644578313253E-17 | 1.65082956259427E-17 | 37861.533059704365 | 3293936.3484006864 | 6267209.5561869135 | 6.442936037948125 | 7.370946594278482 | ||||||||||
| P13020 | Gelsolin [OS=Mus musculus] | 122.934 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 227753 | ENSMUSG00000026879 | Gsn | mmu:227753; P13020; Q3UPB1; Q8R590 | Regulation of actin cytoskeleton | Neutrophil degranulation; Caspase-mediated cleavage of cytoskeletal proteins | 0.396306424610341 | 0.440427841758307 | 1139775.9088509877 | 6438031.44422588 | 9825643.045518672 | 2.497869418910709 | 3.1078016243224496 | |||||||
| Q61398 | Procollagen C-endopeptidase enhancer 1 [OS=Mus musculus] | 120.4 | protein metabolism;other biological processes | enzyme regulator activity;other molecular function | 18542 | ENSMUSG00000029718 | Pcolce | mmu:18542; O35113; Q61398 | mRNA processing | Collagen biosynthesis and modifying enzymes; Crosslinking of collagen fibrils | 1.8644578313253E-17 | 1.65082956259427E-17 | 84503.2651712337 | 2.52047208020085E7 | 2.958750643636163E7 | 8.220471170449764 | 8.451765311848972 | ||||||||
| P26039 | Talin-1 [OS=Mus musculus] | 118.226 | cell adhesion;cell organization and biogenesis;signal transduction | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;other molecular function | 21894 | ENSMUSG00000028465 | Tln1 | A2AIM8; mmu:21894; P26039; Q8VEF0 | Primary focal segmental glomerulosclerosis (FSGS); Integrin-mediated cell adhesion; Focal adhesion | Platelet degranulation ; MAP2K and MAPK activation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; Smooth Muscle Contraction; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 0.994542145304377 | 0.958262397335385 | 147890.2697082064 | 165904.24421521465 | 567933.664164035 | 0.1658236593620016 | 1.9411952948940325 | |||||||
| Q8BPB5 | EGF-containing fibulin-like extracellular matrix protein 1 [OS=Mus musculus] | 117.738 | protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes | extracellular matrix | signal transduction activity or receptor binding;kinase activity;other molecular function | 216616 | ENSMUSG00000020467 | Efemp1 | mmu:216616; Q6Y3N6; Q8BPB5 | 1.8644578313253E-17 | 1.65082956259427E-17 | 29995.485006469138 | 4441372.613318663 | 7007290.288389671 | 7.210116443386737 | 7.867967494142903 | |||||||||
| P09411 | Phosphoglycerate kinase 1 [OS=Mus musculus] | 116.462 | protein metabolism;other metabolic processes;stress response;other biological processes | non-structural extracellular;other membranes;cytosol;mitochondrion;other cell component | kinase activity;other molecular function | 18655 | ENSMUSG00000062070 | Pgk1 | mmu:18655; P09411; Q3TPE6; Q3UKV8; Q5XJE7 | Glycolysis and gluconeogenesis | Gluconeogenesis; Glycolysis | 1.8644578313253E-17 | 1.65082956259427E-17 | 46750.53578358531 | 3210948.6178334034 | 3594147.655304653 | 6.10187286968957 | 6.264522969777913 | |||||||
| P27773 | Protein disulfide-isomerase A3 [OS=Mus musculus] | 115.891 | cell adhesion;cell organization and biogenesis;stress response;signal transduction;other biological processes | non-structural extracellular;other membranes;ER/Golgi;other cell component | nucleic acid binding activity;other molecular function | 14827 | ENSMUSG00000027248 | Pdia3 | mmu:14827; P27773; Q3TEI9; Q3TIL2; Q3UZK8; Q8C2F4; Q99LF6 | ER-Phagosome pathway; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Calnexin/calreticulin cycle | 0.736536116100563 | 0.9135584231482 | 196243.61956605766 | 5161827.016313557 | 6480316.532156386 | 4.717164140703168 | 5.045346629722291 | ||||||||
| P10107 | Annexin A1 [OS=Mus musculus] | 115.566 | cell organization and biogenesis;stress response;transport;signal transduction;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component | enzyme regulator activity;other molecular function | 16952 | ENSMUSG00000024659 | Anxa1 | mmu:16952; P10107 | Spinal cord injury; Prostaglandin synthesis and regulation | G alpha (q) signalling events; G alpha (i) signalling events; Formyl peptide receptors bind formyl peptides and many other ligands | 0.105053536950499 | 1.65082956259427E-17 | 8983.410658903753 | 1675870.316312303 | 6017153.19339518 | 7.543431512773922 | 9.387602086782305 | |||||||
| Cont_Q2KJF1 | Alpha-1B-glycoprotein OS=Bos taurus OX=9913 GN=A1BG PE=1 SV=1 | 115.502 | signal transduction | non-structural extracellular;plasma membrane;other membranes | 518955 | A1BG | bta:518955; Q2KJF1 | Platelet degranulation ; Neutrophil degranulation | 0.655487072215252 | 0.635218461842139 | 9385194.584847162 | 9820849.23751892 | 8859077.038578315 | 0.0654611269786279 | -0.08323025407879855 | ||||||||||
| Cont_Q3MHN5 | Vitamin D-binding protein OS=Bos taurus OX=9913 GN=GC PE=2 SV=1 | 113.599 | other metabolic processes;transport | non-structural extracellular;other cell component | transporter activity;cytoskeletal activity;other molecular function | 530076 | GC | bta:530076; Q3MHN5 | 0.804331105646976 | 0.549057967251154 | 1.2784681703575822E7 | 1.5974245944817802E7 | 1.026921939097026E7 | 0.3213315885051744 | -0.3160897225178924 | ||||||||||
| P17742 | Peptidyl-prolyl cis-trans isomerase A [OS=Mus musculus] | 113.527 | cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes | non-structural extracellular;cytosol;nucleus;other cell component | signal transduction activity or receptor binding;other molecular function | 268373 | ENSMUSG00000071866 | Ppia | mmu:268373; P17742; Q9CWJ5; Q9R137 | Neutrophil degranulation; Basigin interactions | 0.099382125133403 | 0.100219677394751 | 5533917.143041036 | 1.0145464905716315E7 | 3.610988970082183E7 | 0.8744620282868188 | 2.706021065150085 | ||||||||
| Q69ZN7 | Myoferlin [OS=Mus musculus] | 112.647 | cell organization and biogenesis;other metabolic processes;stress response;other biological processes | plasma membrane;other membranes;nucleus | other molecular function | 226101 | ENSMUSG00000048612 | Myof | mmu:226101; Q69ZN7; Q7TMG0; Q80V33; Q8BU64; Q8BU70; Q8BUC1; Q8BVY6; Q8C0D1; Q8R3B4 | 0.964709887217926 | 0.73657372909066 | 74563.786625436 | 322363.41862436634 | 911704.7850761963 | 2.1121410056571723 | 3.6120197152096933 | |||||||||
| P26041 | Moesin [OS=Mus musculus] | 112.068 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function | 17698 | ENSMUSG00000031207 | Msn | B1AX70; mmu:17698; P26041; Q3UL28; Q8BSN4 | Regulation of actin cytoskeleton | Recycling pathway of L1 | 0.0604972675946614 | 1.65082956259427E-17 | 3564499.916018247 | 9136364.2843242 | 1.7052591672350097E7 | 1.3579204878919158 | 2.258219426272545 | |||||||
| P05064 | Fructose-bisphosphate aldolase A [OS=Mus musculus] | 112.015 | cell organization and biogenesis;other metabolic processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | other molecular function | 11674 | ENSMUSG00000030695 | Aldoa | mmu:11674; P05064 | Glycolysis and gluconeogenesis | Platelet degranulation ; Neutrophil degranulation; Gluconeogenesis; Glycolysis | 0.00616383846364181 | 0.101571037453114 | 21908.055682018665 | 4319055.57861477 | 4893427.94836492 | 7.623110619104784 | 7.803240194807217 | |||||||
| B2RQC6 | Multifunctional protein CAD [OS=Mus musculus] | 111.853 | other metabolic processes;stress response;transport;developmental processes;other biological processes | cytosol;nucleus;other cell component | kinase activity;other molecular function | 69719 | ENSMUSG00000013629 | Cad | B2RQC6; B7ZN27; mmu:69719 | Mechanisms associated with pluripotency | Pyrimidine biosynthesis | 0.6681512188534 | 0.69394578118832 | 34439.61575478624 | 448793.6641228067 | 957747.5456383955 | 3.7039113570511004 | 4.797504471859518 | |||||||
| Q8BND5 | Sulfhydryl oxidase 1 [OS=Mus musculus] | 111.186 | cell organization and biogenesis;other biological processes | non-structural extracellular;other membranes;ER/Golgi | other molecular function | 104009 | ENSMUSG00000033684 | Qsox1 | mmu:104009; Q3TDY9; Q3TE19; Q3TR29; Q3UEL4; Q8BND5; Q8K041; Q9DBL6 | Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Neutrophil degranulation | 1.8644578313253E-17 | 1.65082956259427E-17 | 25068.200750320597 | 3849451.1157268733 | 1.052758137572049E7 | 7.262650488092563 | 8.714099860277624 |
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| Accession | Description | Sum PEP Score | Biological Process | Cellular Component | Molecular Function | Entrez Gene ID | Ensembl Gene ID | Gene Symbol | Gene ID | WikiPathways | Reactome Pathways | Abundance Ratio Adj. P-Value: (SQ_6h) / (FM) | Abundance Ratio Adj. P-Value: (SQ_16h) / (FM) | FM_AVERAGE | SQ6h_AVERAGE | SQ16h_AVERAGE | FC_ SQ6h vs FM | FC_ SQ16h vsFM |
| P11276 | Fibronectin [OS=Mus musculus] | 867.353 | cell adhesion;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi | signal transduction activity or receptor binding;enzyme regulator activity;other molecular function | 14268 | ENSMUSG00000026193 | Fn1 | G5E8B8; mmu:14268; P11276; Q61567; Q61568; Q61569; Q64233; Q80UI4 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Inflammatory response pathway; Regulation of actin cytoskeleton; Comprehensive IL-17A signaling; Focal adhesion | ECM proteoglycans; Platelet degranulation ; Cell surface interactions at the vascular wall; Syndecan interactions; MAP2K and MAPK activation; Integrin cell surface interactions; Molecules associated with elastic fibres; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Fibronectin matrix formation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; Degradation of the extracellular matrix; Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells; MET activates PTK2 signaling; GPER1 signaling | 0.156115961659409 | 1.50457038391225E-17 | 2.76414533778046E7 | 1.26297193824042E8 | 2.74958241507436E8 | 2.191917205258659 | 1.1223899456264597 |
| P11087 | Collagen alpha-1(I) chain [OS=Mus musculus] | 797.017 | cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12842 | ENSMUSG00000001506 | Col1a1 | mmu:12842; P11087; Q53WT0; Q60635; Q61367; Q61427; Q63919; Q6PCL3; Q810J9 | Osteoblast signaling; Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Comprehensive IL-17A signaling; Focal adhesion | Cell surface interactions at the vascular wall; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ECM proteoglycans; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; GPVI-mediated activation cascade; GP1b-IX-V activation signalling; Platelet Adhesion to exposed collagen; Platelet Aggregation (Plug Formation); MET activates PTK2 signaling | 1.70336894001643E-17 | 1.50457038391225E-17 | 772438.0834537543 | 5.973622733379293E7 | 8.428319253806247E7 | 6.273043021175366 | 0.4966388360857373 |
| Q01149 | Collagen alpha-2(I) chain [OS=Mus musculus] | 773.662 | cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12843 | ENSMUSG00000029661 | Col1a2 | mmu:12843; Q01149; Q8CGA5 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Focal adhesion | Crosslinking of collagen fibrils; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; ECM proteoglycans; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; GPVI-mediated activation cascade; GP1b-IX-V activation signalling; Platelet Adhesion to exposed collagen; Platelet Aggregation (Plug Formation); MET activates PTK2 signaling | 1.70336894001643E-17 | 1.50457038391225E-17 | 182180.3275564673 | 4.271481968913147E7 | 9.036410240893161E7 | 7.873225701670618 | 1.0810130762443846 |
| P08121 | Collagen alpha-1(III) chain [OS=Mus musculus] | 695.631 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | extracellular matrix;other cell component | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 12825 | ENSMUSG00000026043 | Col3a1 | mmu:12825; P08121; Q61429; Q9CRN7 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Focal adhesion | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ECM proteoglycans; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; MET activates PTK2 signaling | 1.70336894001643E-17 | 1.50457038391225E-17 | 454748.1180174556 | 3.0365458724261332E7 | 6.6157215803336866E7 | 6.061219686329843 | 1.1234673567878595 |
| Q9QXS1 | Plectin [OS=Mus musculus] | 659.702 | cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component | cytoskeletal activity;other molecular function | 18810 | ENSMUSG00000022565 | Plec | E9QN87; mmu:18810; Q6S384; Q6S389; Q6S394; Q9CS65; Q9QUT2; Q9QXQ8; Q9QXQ9; Q9QXR0; Q9QXR1; Q9QXR2; Q9QXR3; Q9QXR4; Q9QXR5; Q9QXR6; Q9QXR7; Q9QXR8; Q9QXR9; Q9QXS0; Q9QXS1; Q9QXS2; Q9QXS3 | Alpha 6 beta 4 integrin signaling pathway; EGFR1 signaling pathway | Type I hemidesmosome assembly; Caspase-mediated cleavage of cytoskeletal proteins | 0.572524806937582 | 0.336550483871782 | 309922.514176982 | 1.01501282886872E7 | 4.28490141732006E7 | 5.033446589054165 | 2.077764050729492 |
| P08122 | Collagen alpha-2(IV) chain [OS=Mus musculus] | 526.992 | RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix | extracellular structural activity | 12827 | ENSMUSG00000031503 | Col4a2 | mmu:12827; P08122; Q3B7C2; Q3TPV9; Q61375; Q66JS5; Q6RCT6; Q6RCT7; Q6U9X1; Q8BPI9; Q8BPK3; Q91VI3 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Focal adhesion | Laminin interactions; Signaling by PDGF; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions | 0.79866917976589 | 0.293387877727491 | 1393534.8123072747 | 1.701609057115766E7 | 5.972856146483746E7 | 3.6100786690336 | 1.8115213581142129 |
| Q3U962 | Collagen alpha-2(V) chain [OS=Mus musculus] | 518.514 | cell organization and biogenesis;developmental processes;other biological processes | extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12832 | ENSMUSG00000026042 | Col5a2 | mmu:12832; Q3TVR2; Q3U962; Q3UHK7; Q3UTT4; Q3V1J6; Q61431; Q7TMS0; Q80VS8 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions | 0.632833892117728 | 0.730324052254867 | 2.4419841082594533E7 | 1.0471363011153279E7 | 2.1079551940947264E7 | -1.221604567961347 | 1.009394958172112 |
| Q05793 | Basement membrane-specific heparan sulfate proteoglycan core protein [OS=Mus musculus] | 507.28 | cell organization and biogenesis;transport;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;ER/Golgi | other molecular function | 15530 | Hspg2 | mmu:15530; Q05793 | 0.553652046981626 | 0.771134174410141 | 171009.25706548532 | 8244737.341084313 | 1.8998181152407136E7 | 5.59132720511202 | 1.204315865984536 | |||
| Q61554 | Fibrillin-1 [OS=Mus musculus] | 499.202 | cell adhesion;other metabolic processes;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 14118 | ENSMUSG00000027204 | Fbn1 | A2AQ53; mmu:14118; Q60826; Q61554 | Comprehensive IL-17A signaling | Integrin cell surface interactions; Degradation of the extracellular matrix; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; TGF-beta receptor signaling activates SMADs; Molecules associated with elastic fibres | 0.84258396038376 | 0.378389090130589 | 81731.837224874 | 5145074.9913376765 | 2.082557122129057E7 | 5.976150130074537 | 2.017092057397419 |
| Q8BTM8 | Filamin-A [OS=Mus musculus] | 493.069 | cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;other molecular function | 192176 | ENSMUSG00000031328 | Flna | B7FAV0; O54934; Q7TQI1; Q8BLK1; Q8BTM8; Q8BTN7; Q8VHX5; Q8VHX8; Q99KQ2 | Mapk signaling pathway; Focal adhesion | Platelet degranulation ; Cell-extracellular matrix interactions; RHO GTPases activate PAKs; GP1b-IX-V activation signalling | 0.67528135146603 | 0.170420349138264 | 218480.8558628913 | 4296604.098486893 | 1.4686023116833666E7 | 4.297618073286841 | 1.7731750217306688 |
| P02463 | Collagen alpha-1(IV) chain [OS=Mus musculus] | 487.707 | cell organization and biogenesis;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix | extracellular structural activity;other molecular function | 12826 | ENSMUSG00000031502 | Col4a1 | mmu:12826; P02463; Q3UHJ4; Q3UJE7; Q3UQV2; Q53X35; Q6GQS7; Q6PHB5; Q99LQ8 | Spinal cord injury; Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Laminin interactions; Signaling by PDGF; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions | 0.936818656936794 | 0.284160251285083 | 262271.417553364 | 8911949.32392111 | 3.3156314746725336E7 | 5.086608533309518 | 1.895470729077585 |
| Q60847 | Collagen alpha-1(XII) chain [OS=Mus musculus] | 480.266 | cell adhesion;developmental processes | other cell component | 12816 | ENSMUSG00000032332 | Col12a1 | mmu:12816; P70322; Q60847 | Assembly of collagen fibrils and other multimeric structures; Collagen chain trimerization; Collagen degradation | 0.162753188077458 | 0.344512840834051 | 80180.17821443231 | 1.0537780206453351E7 | 1.4629541968462234E7 | 7.038109654408597 | 0.473313607436834 | ||
| Q8VDD5 | Myosin-9 [OS=Mus musculus] | 418.364 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;stress response;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;other molecular function | 17886 | ENSMUSG00000022443 | Myh9 | mmu:17886; Q3UHT9; Q3UHU4; Q6KAN6; Q811I2; Q8VDD5 | Primary focal segmental glomerulosclerosis (FSGS) | RHO GTPases activate PAKs; Regulation of actin dynamics for phagocytic cup formation | 0.15125389278925 | 0.118876667035285 | 100319.6147091511 | 7844465.70271172 | 1.9759662960152034E7 | 6.2889995690938765 | 1.3328112474161202 |
| Cont_P02453 | Collagen alpha-1(I) chain OS=Bos taurus OX=9913 GN=COL1A1 PE=1 SV=3 | 414.689 | cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | 282187 | ENSBTAG00000013103 | COL1A1 | bta:282187; P02453; Q3MHM2 | Inflammatory response pathway; Osteoblast signaling; Focal adhesion | Fibronectin matrix formation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Collagen degradation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; Collagen chain trimerization; GPVI-mediated activation cascade; Platelet Aggregation (Plug Formation); Platelet Adhesion to exposed collagen; GP1b-IX-V activation signalling | 0.839216523231753 | 0.58548007712969 | 228542.54091026666 | 1102058.9569362423 | 924822.5329095138 | 2.2696667672876303 | -0.25295295191229616 |
| Cont_P02769 | Albumin OS=Bos taurus OX=9913 GN=ALB PE=1 SV=4 | 390.555 | stress response;other biological processes | non-structural extracellular;other cell component | nucleic acid binding activity;other molecular function | 280717 | ALB | A5PJX3; bta:280717; O02787; P02769; P04277; Q3SZR2 | 0.497906326712893 | 0.598172767155558 | 2.7142766432154403E9 | 2.38097622607819E9 | 2.6841204207378564E9 | -0.18901455448326657 | 0.1728961828070863 | |||
| P01027 | Complement C3 [OS=Mus musculus] | 388.541 | cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular;other cell component | signal transduction activity or receptor binding;enzyme regulator activity | 12266 | ENSMUSG00000024164 | C3 | mmu:12266; P01027; Q61370; Q80XP1 | Complement activation, classical pathway; Tyrobp causal network in microglia; Comprehensive IL-17A signaling | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade; Neutrophil degranulation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; G alpha (i) signalling events; Peptide ligand-binding receptors; Alternative complement activation; Activation of C3 and C5 | 0.762068821001752 | 0.506101547380209 | 3269916.660849947 | 3.6733221642207734E7 | 8.026680998659676E7 | 3.489759659547301 | 1.127718130841963 |
| Cont_Q7SIH1 | Alpha-2-macroglobulin OS=Bos taurus OX=9913 GN=A2M PE=1 SV=2 | 370.864 | non-structural extracellular | enzyme regulator activity;other molecular function | 513856 | ENSBTAG00000018137 | A2M | A8E647; bta:513856; Q7SIH1 | IL-6 signaling pathway | 0.509007335932165 | 0.731111241255251 | 5.423624331449187E7 | 5.23492843648457E7 | 8.250822323914327E7 | -0.05108743825416383 | 0.6563680986370192 | ||
| Cont_Q29443 | Serotransferrin OS=Bos taurus OX=9913 GN=TF PE=2 SV=1 | 343.183 | stress response;transport;other biological processes | non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle | other molecular function | 280705 | TF | bta:280705; Q0IIK2; Q29443 | 0.571407162236119 | 0.600414647182016 | 1.48932090998098E8 | 1.3567523181654152E8 | 1.6257112433260167E8 | -0.13449727704256245 | 0.2609136568979289 | |||
| Cont_P07589 | Fibronectin OS=Bos taurus OX=9913 GN=FN1 PE=1 SV=4 | 337.517 | cell adhesion;cell organization and biogenesis;stress response;developmental processes;other biological processes | non-structural extracellular | signal transduction activity or receptor binding;other molecular function | FN1 | P07589 | 0.802863674292211 | 0.94971810013306 | 166255.75410196633 | 482619.7682389803 | 602598.7403397557 | 1.5374827368819515 | 0.32031064720373065 | ||||
| Q80X90 | Filamin-B [OS=Mus musculus] | 335.882 | cell organization and biogenesis;stress response;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 286940 | ENSMUSG00000025278 | Flnb | E9QNV9; mmu:286940; Q80X90; Q8VHX4; Q8VHX7; Q99KY3 | ISG15 antiviral mechanism | 0.629546282386664 | 0.254729742039053 | 154624.23024854946 | 1865154.4144755967 | 7592568.170254476 | 3.5924567565672367 | 2.0252928818961267 | |
| Cont_P35527 | Keratin, type I cytoskeletal 9 OS=Homo sapiens OX=9606 GN=KRT9 PE=1 SV=3 | 310.424 | cell organization and biogenesis;other biological processes | cytosol;cytoskeleton | cytoskeletal activity | 3857 | ENSG00000171403 | KRT9 | hsa:3857; O00109; P35527; Q0IJ47; Q14665 | Formation of the cornified envelope | 0.964570089320365 | 0.769556732848094 | 2.9224080803851068E7 | 9.369998400542612E7 | 5.1433611479478456E7 | 1.680891153782928 | -0.865337343617375 | |
| Cont_P04264 | Keratin, type II cytoskeletal 1 OS=Homo sapiens OX=9606 GN=KRT1 PE=1 SV=6 | 306.58 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;other molecular function | 3848 | ENSG00000167768 | KRT1 | B2RA01; hsa:3848; P04264; P85925; P86104; Q14720; Q6GSJ0; Q9H298 | Corticotropin-releasing hormone signaling | Formation of the cornified envelope; Neutrophil degranulation; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.89629386854896 | 0.631165145316661 | 1.5397854514739665E8 | 4.476405570139613E8 | 1.7631437693719265E8 | 1.5396114082700514 | -1.344190633959504 |
| P06909 | Complement factor H [OS=Mus musculus] | 292.01 | cell adhesion;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes | non-structural extracellular;plasma membrane;other membranes;mitochondrion;other cell component | other molecular function | 12628 | ENSMUSG00000026365 | Cfh | mmu:12628; P06909; Q6NZK3 | Regulation of Complement cascade | 0.329485122608543 | 1.50457038391225E-17 | 59542.32714759521 | 8439848.284125684 | 2.9357524779450033E7 | 7.147157645999157 | 1.7984413651895645 | |
| P16546 | Spectrin alpha chain, non-erythrocytic 1 [OS=Mus musculus] | 291.854 | cell organization and biogenesis | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 20740 | ENSMUSG00000057738 | Sptan1 | A3KGU6; A3KGU8; P16546; Q8K380; Q9CT05 | FAS pathway and stress induction of HSP regulation | Neutrophil degranulation; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Interaction between L1 and Ankyrins; COPI-mediated anterograde transport; RHOU GTPase cycle; RHOV GTPase cycle; Caspase-mediated cleavage of cytoskeletal proteins | 0.890289034593217 | 0.611910908670005 | 684626.7741473566 | 2263434.85725903 | 8138355.29233573 | 1.7251241667450168 | 1.8462234791150272 |
| Cont_P13645 | Keratin, type I cytoskeletal 10 OS=Homo sapiens OX=9606 GN=KRT10 PE=1 SV=6 | 286.713 | cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes | plasma membrane;cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;other molecular function | 3858 | ENSG00000186395 | KRT10 | hsa:3858; P13645; Q14664; Q8N175 | Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.941696908693733 | 0.561934876627864 | 1.1091978559495355E8 | 3.19749190691826E8 | 1.0914077913761683E8 | 1.5274239747458165 | -1.5507504595301775 | |
| Cont_P35908 | Keratin, type II cytoskeletal 2 epidermal OS=Homo sapiens OX=9606 GN=KRT2 PE=1 SV=2 | 284.975 | cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes | plasma membrane;cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;cytoskeletal activity | 3849 | ENSG00000172867 | KRT2 | hsa:3849; P35908; Q4VAQ2 | Formation of the cornified envelope | 0.933570718645937 | 0.544106843431104 | 4.776750778997586E7 | 7.640800383787991E7 | 3.617272663897294E7 | 0.6776941623987653 | -1.0788214203552526 | |
| Q62059 | Versican core protein [OS=Mus musculus] | 279.715 | cell adhesion;developmental processes | non-structural extracellular;extracellular matrix;other cell component | other molecular function | Vcan | Q62058; Q62059; Q9CUU0 | ECM proteoglycans; Glycosaminoglycan-protein linkage region biosynthesis; CS/DS degradation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; CS-GAG biosynthesis; DS-GAG biosynthesis | 1.70336894001643E-17 | 1.50457038391225E-17 | 104188.56292801573 | 5.89459061512507E7 | 9.510262638582683E7 | 9.144050892318086 | 0.6900935634294152 | |||
| P10493 | Nidogen-1 [OS=Mus musculus] | 275.191 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | other molecular function | 18073 | ENSMUSG00000005397 | Nid1 | mmu:18073; P10493; Q3TKX9; Q8BQI3; Q8C3U8; Q8C9P6 | Laminin interactions; Degradation of the extracellular matrix | 0.461941385639594 | 0.251140212279038 | 322455.2944414853 | 9146738.193898173 | 3.1971627034095198E7 | 4.826086294877998 | 1.8054629019791015 | |
| O88207 | Collagen alpha-1(V) chain [OS=Mus musculus] | 275.025 | cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes | extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12831 | ENSMUSG00000026837 | Col5a1 | A3KGE3; mmu:12831; O88207; Q3UG94; Q6F6B0 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | ECM proteoglycans; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; MET activates PTK2 signaling | 0.311207075116757 | 0.268653947705267 | 80388.83753211687 | 1386447.3981625708 | 3098568.0509616495 | 4.108253882786396 | 1.1602087716820024 |
| P37889 | Fibulin-2 [OS=Mus musculus] | 269.894 | other biological processes | non-structural extracellular | other molecular function | 14115 | ENSMUSG00000064080 | Fbln2 | G5E8B3; mmu:14115; P37889; Q9WUI2 | Molecules associated with elastic fibres | 0.255240026777032 | 0.201227492083465 | 362692.0010392267 | 3.00676966042863E7 | 4.93487108032657E7 | 6.373325613535649 | 0.7147980442653664 | |
| Q8VHX6 | Filamin-C [OS=Mus musculus] | 249.498 | cell organization and biogenesis;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity | 68794 | ENSMUSG00000068699 | Flnc | B2RY80; B9EKT2; mmu:68794; Q6PAI6; Q8VHX6; Q9JJ38 | Cell-extracellular matrix interactions | 0.57290809187594 | 0.962331548063155 | 406087.97266412666 | 1136666.5742976035 | 4459384.47065665 | 1.4849449173931863 | 1.9720354672374187 | |
| Q04857 | Collagen alpha-1(VI) chain [OS=Mus musculus] | 248.981 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component | other molecular function | 12833 | ENSMUSG00000001119 | Col6a1 | mmu:12833; Q04857 | ECM proteoglycans; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Signaling by PDGF; NCAM1 interactions | 0.971216996811237 | 0.962331548063155 | 76865.2077476112 | 1.4473176745930666E7 | 1.9886194591010433E7 | 7.556835176514044 | 0.45838561282899787 | |
| Cont_Q2UVX4 | Complement C3 OS=Bos taurus OX=9913 GN=C3 PE=1 SV=2 | 247.154 | cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular;other cell component | signal transduction activity or receptor binding;enzyme regulator activity | 280677 | ENSBTAG00000017280 | C3 | bta:280677; Q2KIZ4; Q2UVX4 | Complement and coagulation cascades; Complement activation, classical pathway | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Neutrophil degranulation; Peptide ligand-binding receptors; G alpha (i) signalling events; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade; Alternative complement activation; Activation of C3 and C5 | 0.506364847510615 | 0.573945385766997 | 1.4686759191254234E7 | 1.196234797265725E7 | 1.6127794015790733E7 | -0.2960154932546844 | 0.43104852809057914 |
| Q62261 | Spectrin beta chain, non-erythrocytic 1 [OS=Mus musculus] | 244.684 | cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 20742 | ENSMUSG00000020315 | Sptbn1 | A2AFU1; mmu:20742; Q3TEM7; Q5SQL8; Q5SQL9; Q62261; Q9QWJ7 | COPI-mediated anterograde transport; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; RHOU GTPase cycle; Interaction between L1 and Ankyrins; RHOV GTPase cycle | 0.831411077141515 | 0.693719649766064 | 492454.03878621367 | 2299979.2063157237 | 6417771.720584608 | 2.223559830255895 | 1.4804516559416234 | |
| Q640N1 | Adipocyte enhancer-binding protein 1 [OS=Mus musculus] | 239.707 | protein metabolism;other biological processes | nucleus;other cell component | nucleic acid binding activity;other molecular function | 11568 | ENSMUSG00000020473 | Aebp1 | mmu:11568; O88442; Q3TVV5; Q3TWA7; Q3TX56; Q3TXB2; Q5NCI9; Q61281; Q640N1 | 0.631359014803774 | 0.605387748357992 | 4843934.666021533 | 1.8648394999714002E7 | 3.1901344171106894E7 | 1.944800156743329 | 0.7745657453366123 | ||
| P57780 | Alpha-actinin-4 [OS=Mus musculus] | 239.42 | cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes | cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 60595 | ENSMUSG00000054808 | Actn4 | mmu:60595; P57780 | Primary focal segmental glomerulosclerosis (FSGS) | Platelet degranulation | 0.19149089837131 | 1.50457038391225E-17 | 20900.169415734228 | 4440337.50144963 | 1.1658414413951913E7 | 7.73101089020448 | 1.3926303478854152 |
| Q7TPR4 | Alpha-actinin-1 [OS=Mus musculus] | 235.529 | cell adhesion;cell organization and biogenesis;other biological processes | plasma membrane;other membranes;cytoskeleton;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function | 109711 | ENSMUSG00000015143 | Actn1 | mmu:109711; Q7TPR4 | Regulation of actin cytoskeleton; Integrin-mediated cell adhesion; Focal adhesion | Platelet degranulation ; RHOF GTPase cycle; RHOBTB2 GTPase cycle; RHOD GTPase cycle; Regulation of cytoskeletal remodeling and cell spreading by IPP complex components | 0.941696908693733 | 0.819280225722906 | 486802.1989182571 | 3717490.65968503 | 9946958.94260729 | 2.9329215275350284 | 1.419926404270893 |
| P02468 | Laminin subunit gamma-1 [OS=Mus musculus] | 230.882 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | Lamc1 | P02468 | 0.675951294045723 | 0.459134305737471 | 18104.5719498812 | 3246292.9185144133 | 7951596.802164167 | 7.486295305072058 | 1.292451422124767 | ||||
| Q91ZX7 | Prolow-density lipoprotein receptor-related protein 1 [OS=Mus musculus] | 230.497 | other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;other molecular function | 16971 | Lrp1 | mmu:16971; Q61291; Q91ZX7; Q920Y4 | Statin pathway; Wnt signaling pathway | Scavenging of heme from plasma; Retinoid metabolism and transport | 0.150830220548111 | 0.133639440745791 | 30670.78727387535 | 2243610.9879279765 | 5724840.5342227295 | 6.192813544488277 | 1.351412953764416 | |
| Cont_P60712 | Actin, cytoplasmic 1 OS=Bos taurus OX=9913 GN=ACTB PE=1 SV=1 | 225.45 | cell organization and biogenesis;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component | enzyme regulator activity;cytoskeletal activity;other molecular function | 100033878; 100135470; 100173832; 101844587; 102139853; 11461; 118833809; 280979; 396526; 403580; 414396; 443052; 450133; 60; 81822 | ENSBTAG00000026199; ENSCAFG00000016020; ENSCAFG00030015381; ENSCAFG00040015695; ENSCPOG00000013467; ENSG00000075624; ENSMAUG00000008763; ENSMUSG00000029580; ENSOARG00040012985; ENSOARG00180022443; ENSOARG00185023855; ENSOARG00215030140; ENSOARG00225009314; ENSPPYG00000017336; ENSPTRG00000018890; ENSRNOG00000034254; ENSSSCG00000007585; ENSSSCG00030003451; ENSSSCG00035038792; ENSSSCG00040049462; ENSSSCG00045027458; ENSSSCG00050065025; ENSSSCG00055012597; ENSSSCG00060019124; ENSSSCG00065037921; ENSSSCG00070011353; ENSSSCG00105030144; ENSSSCG00110026965; ENSSSCG00115013637; ENSSSCG00130033784 | Actb; ACTB | A5D961; A5PKA1; bta:280979; cfa:403580; cpoc:100135470; csab:103246953; ecb:100033878; gga:396526; hsa:60; maua:101844587; mmu:11461; O18840; oas:443052; P02570; P60706; P60707; P60708; P60709; P60710; P60711; P60712; P60713; P70514; P99021; pon:100173832; ptr:450133; Q11209; Q11211; Q3SZD2; Q3TI89; Q3TVP6; Q4L0Y2; Q4R561; Q5R1X3; Q5R582; Q5R6G0; Q64316; Q6QAQ1; Q6ZWM3; Q711N9; Q71FK5; Q75MN2; Q76N69; Q8MIJ0; Q8SPX4; Q95164; Q96B34; Q96HG5; rno:81822; ssc:414396 | FAS pathway and stress induction of HSP regulation; Actin cytoskeleton regulation; Myometrial relaxation and contraction pathways; Focal adhesion; Arrhythmogenic right ventricular cardiomyopathy; Pathogenic Escherichia coli infection; Common pathways underlying drug addiction; Myometrial relaxation and contraction pathways; Focal adhesion; Fas ligand pathway and stress induction of heat shock proteins; Pathogenic Escherichia coli infection; Arrhythmogenic right ventricular cardiomyopathy; Focal adhesion; Myometrial relaxation and contraction pathways; Regulation of actin cytoskeleton; Myometrial relaxation and contraction pathways; Ebola virus infection in host; Acute viral myocarditis; Thermogenesis; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Overlap between signal transduction pathways contributing to LMNA laminopathies; Pleural mesothelioma; Regulation of actin cytoskeleton; Network map of SARS-CoV-2 signaling; Regulation of actin cytoskeleton; Regulation of actin cytoskeleton; Focal adhesion | Formation of the canonical BAF (cBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); Regulation of actin dynamics for phagocytic cup formation; EPH-ephrin mediated repulsion of cells; Formation of annular gap junctions; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; RHO GTPases Activate Formins; RHOF GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; B-WICH complex positively regulates rRNA expression; Regulation of CDH1 Function; Formation of the dystrophin-glycoprotein complex (DGC); Formation of the canonical BAF (cBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); RHO GTPases Activate WASPs and WAVEs; UCH proteinases; DNA Damage Recognition in GG-NER; Formation of the non-canonical BAF (ncBAF) complex; RHO GTPases activate IQGAPs; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Cell-extracellular matrix interactions; MAP2K and MAPK activation; Interaction between L1 and Ankyrins; RHOF GTPase cycle; DNA Damage Recognition in GG-NER; MAP2K and MAPK activation; RHO GTPases Activate Formins; Clathrin-mediated endocytosis; UCH proteinases; RHOF GTPase cycle; DNA Damage Recognition in GG-NER; EPH-ephrin mediated repulsion of cells; VEGFA-VEGFR2 Pathway; Regulation of actin dynamics for phagocytic cup formation; Adherens junctions interactions; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); RHO GTPases Activate WASPs and WAVEs; B-WICH complex positively regulates rRNA expression; Regulation of CDH1 Function; EPHB-mediated forward signaling; Formation of the non-canonical BAF (ncBAF) complex; Formation of the canonical BAF (cBAF) complex; Formation of annular gap junctions; RHO GTPases activate IQGAPs; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; RHO GTPases Activate WASPs and WAVEs; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RHO GTPases activate IQGAPs; RHO GTPases Activate Formins; RHOF GTPase cycle; Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs); B-WICH complex positively regulates rRNA expression; Signaling by BRAF and RAF1 fusions; UCH proteinases; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; VEGFA-VEGFR2 Pathway; Formation of the dystrophin-glycoprotein complex (DGC); Factors involved in megakaryocyte development and platelet production; Regulation of MITF-M-dependent genes involved in pigmentation; Formation of the canonical BAF (cBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); EPH-ephrin mediated repulsion of cells; HATs acetylate histones; Interaction between L1 and Ankyrins; Prefoldin mediated transfer of substrate to CCT/TriC; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Adherens junctions interactions; Regulation of CDH1 Function; Formation of the non-canonical BAF (ncBAF) complex; DNA Damage Recognition in GG-NER; Formation of the polybromo-BAF (pBAF) complex; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Formation of annular gap junctions; Folding of actin by CCT/TriC; Cell-extracellular matrix interactions; MAP2K and MAPK activation; RHO GTPases Activate Formins; Recycling pathway of L1; RHO GTPases activate IQGAPs; Clathrin-mediated endocytosis; Formation of the dystrophin-glycoprotein complex (DGC); EPHB-mediated forward signaling; UCH proteinases; B-WICH complex positively regulates rRNA expression; Adherens junctions interactions; Formation of the non-canonical BAF (ncBAF) complex; Formation of annular gap junctions; Formation of the polybromo-BAF (pBAF) complex; VEGFA-VEGFR2 Pathway; Cell-extracellular matrix interactions; RHO GTPases Activate WASPs and WAVEs; Regulation of CDH1 Function; Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; UCH proteinases; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); Formation of the polybromo-BAF (pBAF) complex; B-WICH complex positively regulates rRNA expression; DNA Damage Recognition in GG-NER; Formation of the canonical BAF (cBAF) complex; RHO GTPases Activate Formins; Regulation of CDH1 Function; Interaction between L1 and Ankyrins; RHOF GTPase cycle; Formation of the non-canonical BAF (ncBAF) complex; Adherens junctions interactions; Formation of the dystrophin-glycoprotein complex (DGC); VEGFA-VEGFR2 Pathway; RHO GTPases Activate WASPs and WAVEs; Cell-extracellular matrix interactions; EPHB-mediated forward signaling; MAP2K and MAPK activation; Recycling pathway of L1; RHO GTPases activate IQGAPs; Formation of annular gap junctions; B-WICH complex positively regulates rRNA expression; UCH proteinases; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); MAP2K and MAPK activation; Formation of the polybromo-BAF (pBAF) complex; RHO GTPases Activate Formins; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases Activate WASPs and WAVEs; Formation of the dystrophin-glycoprotein complex (DGC); VEGFA-VEGFR2 Pathway; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; DNA Damage Recognition in GG-NER; RHOF GTPase cycle; Cell-extracellular matrix interactions; Adherens junctions interactions; Formation of the non-canonical BAF (ncBAF) complex; Formation of the canonical BAF (cBAF) complex; RHO GTPases activate IQGAPs; Regulation of CDH1 Function; Gap junction degradation; Formation of annular gap junctions; Regulation of actin dynamics for phagocytic cup formation; RHOF GTPase cycle; Clathrin-mediated endocytosis; RHO GTPases Activate Formins; Cell-extracellular matrix interactions; VEGFA-VEGFR2 Pathway; Adherens junctions interactions; RHO GTPases activate IQGAPs; UCH proteinases; EPHB-mediated forward signaling; MAP2K and MAPK activation; RHO GTPases Activate WASPs and WAVEs; Formation of the dystrophin-glycoprotein complex (DGC); Formation of annular gap junctions; Formation of the canonical BAF (cBAF) complex; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of the non-canonical BAF (ncBAF) complex; Regulation of CDH1 Function | 1.70336894001643E-17 | 1.50457038391225E-17 | 1996659.4544256767 | 5.335770948168167E7 | 1.0984219759318356E8 | 4.74003654023996 | 1.0416637530965958 |
| P63260 | Actin, cytoplasmic 2 [OS=Mus musculus] | 217.791 | cell organization and biogenesis;stress response;developmental processes;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 11465 | ENSMUSG00000062825 | Actg1 | mmu:11465; P02571; P14104; P63260; P99022 | Myometrial relaxation and contraction pathways; Regulation of actin cytoskeleton; Focal adhesion | Platelet degranulation ; RHO GTPases activate IQGAPs; Adherens junctions interactions; Regulation of CDH1 Function; RHO GTPases Activate Formins; Regulation of actin dynamics for phagocytic cup formation; Interaction between L1 and Ankyrins; MAP2K and MAPK activation; Recycling pathway of L1; Clathrin-mediated endocytosis; Formation of the dystrophin-glycoprotein complex (DGC); EPHB-mediated forward signaling; RHOF GTPase cycle; Formation of annular gap junctions; VEGFA-VEGFR2 Pathway; Cell-extracellular matrix interactions; RHO GTPases Activate WASPs and WAVEs; RHOBTB2 GTPase cycle | 1.70336894001643E-17 | 1.50457038391225E-17 | 126248.83655432604 | 256671.2110968777 | 1.0236513958265139 | ||
| P33434 | 72 kDa type IV collagenase [OS=Mus musculus] | 212.03 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes | extracellular matrix;plasma membrane;other membranes;cytoskeleton;mitochondrion;nucleus;other cell component | other molecular function | 17390 | ENSMUSG00000031740 | Mmp2 | mmu:17390; P33434 | Lung fibrosis; IL-3 signaling pathway; Matrix metalloproteinases | Collagen degradation; Extra-nuclear estrogen signaling; EPH-ephrin mediated repulsion of cells; Activation of Matrix Metalloproteinases | 0.708142491896103 | 0.342075680986172 | 2.5908623508144036E7 | 5.359802560613743E7 | 8.73371018908004E7 | 1.0487474879918894 | 0.7044148019141078 |
| P19096 | Fatty acid synthase [OS=Mus musculus] | 203.372 | other metabolic processes;stress response;other biological processes | plasma membrane;other membranes;cytosol;ER/Golgi;other cell component | other molecular function | 14104 | ENSMUSG00000025153 | Fasn | B1ATU8; mmu:14104; P19096; Q6PB72; Q8C4Z0; Q9EQR0 | Fatty acid biosynthesis; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-9 fatty acid synthesis; Elongation of (very) long chain fatty acids | Fatty acyl-CoA biosynthesis; Vitamin B5 (pantothenate) metabolism | 0.605074788683686 | 0.951921622352553 | 102793.32580216101 | 892753.3234074336 | 2995475.6339221266 | 3.1185150036599216 | 1.7464515936644316 |
| Cont_Q3SZ57 | Alpha-fetoprotein OS=Bos taurus OX=9913 GN=AFP PE=2 SV=1 | 202.89 | other metabolic processes;developmental processes;other biological processes | non-structural extracellular;other cell component | other molecular function | 506011 | ENSBTAG00000017131 | AFP | bta:506011; Q3SZ57 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 0.553772240900005 | 0.605387748357992 | 3.8603879197485335E7 | 3.679174310656657E7 | 4.2915740009991035E7 | -0.06936379778833635 | 0.22212484601395752 | |
| P48678 | Prelamin-A/C [OS=Mus musculus] | 202.607 | cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes | other membranes;cytoskeleton;nucleus;other cell component | other molecular function | 16905 | ENSMUSG00000028063 | Lmna | B3RH23; B3RH24; mmu:16905; P11516; P48678; P97859; Q3TIH0; Q3TTS8; Q3U733; Q3U7I5; Q3UCA0; Q3UCJ8; Q3UCU3; Q91WF2; Q9DC21 | Adipogenesis genes; FAS pathway and stress induction of HSP regulation | 1.70336894001643E-17 | 0.139423967594304 | 75722.11050192213 | 6289356.16248022 | 5.369543399964929E7 | 6.37605390470787 | 3.0938151716360243 | |
| Q02788 | Collagen alpha-2(VI) chain [OS=Mus musculus] | 202.37 | cell adhesion;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component | other molecular function | 12834 | ENSMUSG00000020241 | Col6a2 | mmu:12834; Q02788; Q05505; Q8C972; Q8K229 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | ECM proteoglycans; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation | 0.767312384697355 | 0.633123216104285 | 121237.29953889274 | 1.173163988850227E7 | 2.0595787144729633E7 | 6.59642725930643 | 0.8119445729458827 |
| P97927 | Laminin subunit alpha-4 [OS=Mus musculus] | 199.33 | cell adhesion;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | signal transduction activity or receptor binding | 16775 | ENSMUSG00000019846 | Lama4 | mmu:16775; O88785; P70409; P97927; Q14BF2 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Formation of the dystrophin-glycoprotein complex (DGC); Laminin interactions; MET activates PTK2 signaling | 0.825047045401531 | 0.952104483873957 | 390078.69973194966 | 3065544.409694903 | 5760601.1965567535 | 2.9743061775357336 | 0.9100760795197015 |
| P20152 | Vimentin [OS=Mus musculus] | 183.446 | cell organization and biogenesis;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component | cytoskeletal activity;nucleic acid binding activity;other molecular function | 22352 | ENSMUSG00000026728 | Vim | mmu:22352; O08704; P20152; Q8CCH1 | Spinal cord injury; Primary focal segmental glomerulosclerosis (FSGS); Alpha 6 beta 4 integrin signaling pathway | Aggrephagy; Striated Muscle Contraction; Caspase-mediated cleavage of cytoskeletal proteins; RHOBTB1 GTPase cycle | 0.137621774180062 | 1.50457038391225E-17 | 1112472.104030337 | 1.292797841903164E7 | 7.464184195594883E7 | 3.5386556297624625 | 2.529487893505153 |
| Q64727 | Vinculin [OS=Mus musculus] | 182.753 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | plasma membrane;other membranes;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 22330 | ENSMUSG00000021823 | Vcl | mmu:22330; Q64727; Q8BP32; Q8BS46; Q922C5; Q922D9 | Primary focal segmental glomerulosclerosis (FSGS); IL-3 signaling pathway; Regulation of actin cytoskeleton; Integrin-mediated cell adhesion; Focal adhesion | Neutrophil degranulation; High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells; Platelet degranulation ; MAP2K and MAPK activation; Smooth Muscle Contraction; Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells; Regulation of CDH1 Function | 0.504745711776551 | 0.238791978742132 | 126150.06188907423 | 2359150.5810886133 | 6758257.200309387 | 4.225054687393182 | 1.5183837498676935 |
| Q8K4G1 | Latent-transforming growth factor beta-binding protein 4 [OS=Mus musculus] | 180.216 | cell-cell signaling;cell organization and biogenesis;transport;signal transduction | non-structural extracellular;extracellular matrix | other molecular function | 108075 | ENSMUSG00000040488 | Ltbp4 | E9QPD9; mmu:108075; Q8K4G0; Q8K4G1 | TGF-beta receptor signaling activates SMADs; Molecules associated with elastic fibres | 0.170566190602959 | 1.50457038391225E-17 | 50068.58855747415 | 2657641.7444799202 | 7291299.088613093 | 5.730097043103805 | 1.4560292425135843 | |
| Q68FD5 | Clathrin heavy chain 1 [OS=Mus musculus] | 180.117 | cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes | plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component | nucleic acid binding activity;other molecular function | 67300 | ENSMUSG00000047126 | Cltc | mmu:67300; Q68FD5 | IL-7 signaling pathway; Kit receptor signaling pathway | MHC class II antigen presentation; Recycling pathway of L1; Cargo recognition for clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis; LDL clearance; Retrograde neurotrophin signalling; Formation of annular gap junctions; Lysosome Vesicle Biogenesis; WNT5A-dependent internalization of FZD4; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation; RHOU GTPase cycle; RHOV GTPase cycle | 0.413413145615294 | 1.50457038391225E-17 | 14581.209031729499 | 2078296.563295177 | 6830362.818457293 | 7.155147375878066 | 1.716560679478457 |
| P02469 | Laminin subunit beta-1 [OS=Mus musculus] | 179.863 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;nucleus;other cell component | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 16777 | ENSMUSG00000002900 | Lamb1 | E9PXZ9; P02469 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Inflammatory response pathway; Alpha 6 beta 4 integrin signaling pathway; Focal adhesion | 0.891178501081124 | 0.526489846375643 | 1.0460538665187027E7 | 2.1078383512013834E7 | 1.149610392953332E7 | 1.0108070867970473 | -0.874619222314641 | |
| Q01853 | Transitional endoplasmic reticulum ATPase [OS=Mus musculus] | 179.055 | cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;other biological processes | other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;enzyme regulator activity;other molecular function | 269523 | ENSMUSG00000028452 | Vcp | mmu:269523; Q01853; Q3TFH9; Q3TIM2; Q3TXN9; Q6PI18; Q8BSR6; Q8CEG4 | IL-9 signaling pathway | RHOH GTPase cycle; Neutrophil degranulation; Protein methylation; Ovarian tumor domain proteases; Neddylation; ABC-family proteins mediated transport; Translesion Synthesis by POLH; Hedgehog ligand biogenesis; KEAP1-NFE2L2 pathway; HSF1 activation; N-glycan trimming in the ER and Calnexin/Calreticulin cycle; Josephin domain DUBs | 0.953867932777128 | 0.808626104853287 | 621808.5300221853 | 4463650.11042755 | 1.2770955118061693E7 | 2.843681630952846 | 1.5165705767836266 |
| Q03350 | Thrombospondin-2 [OS=Mus musculus] | 178.303 | cell adhesion;other biological processes | non-structural extracellular;extracellular matrix;other cell component | other molecular function | 21826 | ENSMUSG00000023885 | Thbs2 | mmu:21826; Q03350; Q8CG21 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Signaling by PDGF; O-glycosylation of TSR domain-containing proteins | 0.535702081245677 | 0.49027994509233 | 1929828.2171104867 | 4211942.301314384 | 1.05864549049655E7 | 1.1260132409788162 | 1.3296619753283232 |
| Q80YX1 | Tenascin [OS=Mus musculus] | 175.9 | cell adhesion;cell-cell signaling;cell organization and biogenesis;stress response;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | signal transduction activity or receptor binding;other molecular function | 21923 | ENSMUSG00000028364 | Tnc | mmu:21923; Q64706; Q80YX1; Q80YX2 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Integrin cell surface interactions; ECM proteoglycans; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 0.474732236495646 | 0.560799429150649 | 20862.416559578665 | 96243.5238250637 | 211010.04547923067 | 2.205783186329275 | 1.132550311530058 |
| Q61147 | Ceruloplasmin [OS=Mus musculus] | 175.43 | cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular | other molecular function | 12870 | ENSMUSG00000003617 | Cp | mmu:12870; Q61147; Q6P5C8 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Iron uptake and transport; Metal ion SLC transporters | 0.470567140616547 | 0.232756100865398 | 116072.0240394514 | 1756646.5467629798 | 3587720.1567995367 | 3.9197317398446314 | 1.0302434268158966 | |
| Q3UQ28 | Peroxidasin homolog [OS=Mus musculus] | 173.636 | cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes | extracellular matrix;ER/Golgi;other cell component | extracellular structural activity;other molecular function | 69675 | ENSMUSG00000020674 | Pxdn | A4FU83; E9QNQ9; mmu:69675; Q3UQ28 | Crosslinking of collagen fibrils | 0.64860195920101 | 0.481687712882875 | 52188.79804577449 | 1748064.7562207088 | 5865453.59009746 | 5.06587464375226 | 1.7464840499849725 | |
| Q61316 | Heat shock 70 kDa protein 4 [OS=Mus musculus] | 169.044 | protein metabolism;other metabolic processes | other cell component | other molecular function | Hspa4 | Q61316 | Regulation of HSF1-mediated heat shock response | 0.760498481134506 | 0.704651587991194 | 51496.56273693644 | 1450318.0074060035 | 4790126.20554149 | 4.815749321311804 | 1.7236943963098632 | |||
| Cont_P02533 | Keratin, type I cytoskeletal 14 OS=Homo sapiens OX=9606 GN=KRT14 PE=1 SV=4 | 164.831 | cell organization and biogenesis;other biological processes | plasma membrane;cytosol;cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 3861 | ENSG00000186847 | KRT14 | hsa:3861; P02533; Q14715; Q53XY3; Q9BUE3; Q9UBN2; Q9UBN3; Q9UCY4 | Corticotropin-releasing hormone signaling | Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin; Developmental Lineage of Mammary Gland Myoepithelial Cells; Type I hemidesmosome assembly | 0.887279041944908 | 0.666244110962191 | 6829492.454091667 | 2.9333304518974166E7 | 9460012.597296894 | 2.1026893347000493 | -1.6326255960338534 |
| P11499 | Heat shock protein HSP 90-beta [OS=Mus musculus] | 164.719 | cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component | enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function | 15516 | ENSMUSG00000023944 | Hsp90ab1 | mmu:15516; O89078; P11499; Q3UIQ7 | Focal adhesion: PI3K-Akt-mTOR signaling pathway | Neutrophil degranulation; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of actin dynamics for phagocytic cup formation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Attenuation phase; Estrogen-dependent gene expression; Sema3A PAK dependent Axon repulsion; Aryl hydrocarbon receptor signalling; DDX58/IFIH1-mediated induction of interferon-alpha/beta; HSF1 activation; RHOBTB2 GTPase cycle; The NLRP3 inflammasome | 1.70336894001643E-17 | 1.50457038391225E-17 | 166033.98771248801 | 1.1608041082716169E7 | 4.22825068683512E7 | 6.127502123927423 | 1.8649363840924498 |
| Q9JKF1 | Ras GTPase-activating-like protein IQGAP1 [OS=Mus musculus] | 163.926 | cell organization and biogenesis;developmental processes;signal transduction;other biological processes | plasma membrane;other membranes;cytoskeleton;nucleus;other cell component | enzyme regulator activity;other molecular function | 29875 | ENSMUSG00000030536 | Iqgap1 | G3UW45; mmu:29875; Q9JKF1 | G13 signaling pathway; Regulation of actin cytoskeleton | RHO GTPases activate IQGAPs; Neutrophil degranulation; RAC1 GTPase cycle; RAC2 GTPase cycle; RHOA GTPase cycle; MAP2K and MAPK activation; RHOQ GTPase cycle; RHOC GTPase cycle; RHOU GTPase cycle; RHOV GTPase cycle; Nephrin family interactions | 0.991639536226218 | 0.787568130909409 | 58984.367745696 | 944145.2185002686 | 3795509.9873349466 | 4.000604214958747 | 2.007213065802415 |
| P52480 | Pyruvate kinase PKM [OS=Mus musculus] | 163.393 | cell organization and biogenesis;other metabolic processes;other biological processes | cytosol;ER/Golgi;nucleus;other cell component | nucleic acid binding activity;kinase activity;other molecular function | 18746 | ENSMUSG00000032294 | Pkm | mmu:18746; P52480; Q3TBV8; Q3TBW5; Q3TC59; Q3U1X3; Q3U5P6; Q4VC20; Q64484; Q91YI8; Q9CWB1 | Glycolysis and gluconeogenesis; Purine metabolism | Neutrophil degranulation; Pyruvate metabolism; Glycolysis; Regulation of pyruvate metabolism | 1.70336894001643E-17 | 1.50457038391225E-17 | 224031.9482756436 | 1.3595916090065738E7 | 3.1698865102110166E7 | 5.923325069145465 | 1.2212578260965212 |
| P63017 | Heat shock cognate 71 kDa protein [OS=Mus musculus] | 161.557 | cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component | signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function | 15481 | ENSMUSG00000015656 | Hspa8 | mmu:15481; P08109; P12225; P63017; Q3U6R0; Q3U764; Q3U7D7; Q3U7E2; Q3U9B4; Q3U9G0; Q3UGM0; Q5FWJ6; Q62373; Q62374; Q62375; Q6NZD0 | Mapk signaling pathway; Exercise-induced circadian regulation | Neutrophil degranulation; mRNA Splicing - Major Pathway; Regulation of HSF1-mediated heat shock response; PKR-mediated signaling; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis; Attenuation phase; Lysosome Vesicle Biogenesis; GABA synthesis, release, reuptake and degradation; AUF1 (hnRNP D0) binds and destabilizes mRNA; Protein methylation | 1.70336894001643E-17 | 1.50457038391225E-17 | 232221.67704249235 | 1.2001189016638666E7 | 3.440867978172333E7 | 5.6915308887768115 | 1.5195951909349734 |
| Q9JHU4 | Cytoplasmic dynein 1 heavy chain 1 [OS=Mus musculus] | 161.009 | cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes | cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 13424 | ENSMUSG00000018707 | Dync1h1 | E9QM71; mmu:13424; Q9JHU4 | MHC class II antigen presentation; Neutrophil degranulation; Separation of Sister Chromatids; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; COPI-mediated anterograde transport; Recruitment of NuMA to mitotic centrosomes; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-independent Golgi-to-ER retrograde traffic; Aggrephagy; Anchoring of the basal body to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; AURKA Activation by TPX2 | 0.936818656936794 | 0.758743075163871 | 294620.0253220563 | 1462326.6297541 | 5162177.518126 | 2.3113381932709602 | 1.819714161940933 | |
| Q99K41 | EMILIN-1 [OS=Mus musculus] | 157.011 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 100952 | ENSMUSG00000029163 | Emilin1 | mmu:100952; Q99K41 | Molecules associated with elastic fibres | 1.70336894001643E-17 | 1.50457038391225E-17 | 384416.66366236034 | 2364922.89508055 | 2.6210503669211938 | |||
| Q61879 | Myosin-10 [OS=Mus musculus] | 146 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;nucleic acid binding activity;other molecular function | 77579 | ENSMUSG00000020900 | Myh10 | mmu:77579; Q5SV63; Q61879 | Regulation of actin cytoskeleton | RHO GTPases activate PAKs | 0.933545599871938 | 0.676239752697828 | 123378.89612673952 | 562909.3462758837 | 1089526.38375758 | 2.1898069585990854 | 0.9527266255660732 |
| Cont_P00761 | Trypsin OS=Sus scrofa OX=9823 PE=1 SV=1 | 143.502 | protein metabolism;other biological processes | non-structural extracellular | other molecular function | 0.34040294575649 | 0.357784551188889 | 5.863252009900073E9 | 4.479417756781787E9 | 2.35988129070601E9 | -0.38838984667240734 | -0.9245969308204053 | ||||||
| P20029 | Endoplasmic reticulum chaperone BiP [OS=Mus musculus] | 142.966 | protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component | enzyme regulator activity;translation activity;other molecular function | 14828 | ENSMUSG00000026864 | Hspa5 | mmu:14828; O35642; P20029; Q3UFF2; Q61630 | Mapk signaling pathway | Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Regulation of HSF1-mediated heat shock response | 1.70336894001643E-17 | 1.50457038391225E-17 | 8403011.594768586 | 1.57890948929286E7 | 0.9099500914019807 | ||
| Cont_P13647 | Keratin, type II cytoskeletal 5 OS=Homo sapiens OX=9606 GN=KRT5 PE=1 SV=3 | 142.395 | cell organization and biogenesis;other biological processes | cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;cytoskeletal activity;other molecular function | 3852 | ENSG00000186081 | KRT5 | hsa:3852; P13647; Q6PI71; Q6UBJ0; Q8TA91 | Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin; Developmental Lineage of Mammary Stem Cells; Developmental Lineage of Mammary Gland Myoepithelial Cells; Type I hemidesmosome assembly | 0.746833150482801 | 0.707170943024881 | 5615099.536380176 | 2.8752414910160065E7 | 1.3998817771053001E7 | 2.356299630862457 | -1.0383781390912068 | |
| Cont_P08779 | Keratin, type I cytoskeletal 16 OS=Homo sapiens OX=9606 GN=KRT16 PE=1 SV=4 | 140.751 | cell organization and biogenesis;stress response;other biological processes | plasma membrane;cytosol;cytoskeleton | cytoskeletal activity | 3868 | ENSG00000186832 | KRT16 | A8K488; hsa:3868; P08779; P30654; Q16402; Q9UBG8 | Vitamin D receptor pathway | Formation of the cornified envelope | 0.887279041944908 | 0.761460393544015 | 1275668.1444026066 | 5401589.786976026 | 2569640.8216647534 | 2.082131009886816 | -1.0718173643929836 |
| Cont_P02465 | Collagen alpha-2(I) chain OS=Bos taurus OX=9913 GN=COL1A2 PE=1 SV=2 | 139.99 | non-structural extracellular;extracellular matrix | extracellular structural activity;other molecular function | 282188 | ENSBTAG00000013472 | COL1A2 | A6QP13; bta:282188; O62649; P02465 | Inflammatory response pathway; Focal adhesion | Fibronectin matrix formation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Collagen degradation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; Collagen chain trimerization; GPVI-mediated activation cascade; Platelet Aggregation (Plug Formation); Platelet Adhesion to exposed collagen; GP1b-IX-V activation signalling | 0.488872343346086 | 0.421836754550416 | 70110.45197339094 | 48702.045776696206 | 54970.44581499727 | -0.5256471599506324 | 0.1746738044170317 | |
| Cont_P12763 | Alpha-2-HS-glycoprotein OS=Bos taurus OX=9913 GN=AHSG PE=1 SV=2 | 132.772 | stress response;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component | enzyme regulator activity | 280988 | AHSG | A6QLF7; bta:280988; P12763 | Neutrophil degranulation; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 0.36488675645736 | 0.624272910267193 | 6.882384659684638E8 | 4.440672611032756E8 | 7.064361313920757E8 | -0.632130314815548 | 0.6697809205631783 | ||
| P07901 | Heat shock protein HSP 90-alpha [OS=Mus musculus] | 132.382 | cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component | signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function | 15519 | ENSMUSG00000021270 | Hsp90aa1 | mmu:15519; P07901 | EBV LMP1 signaling; Focal adhesion: PI3K-Akt-mTOR signaling pathway; IL-6 signaling pathway; IL-2 signaling pathway | Regulation of necroptotic cell death; Recruitment of NuMA to mitotic centrosomes; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of actin dynamics for phagocytic cup formation; Neutrophil degranulation; Downregulation of ERBB2 signaling; Anchoring of the basal body to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; AURKA Activation by TPX2; Extra-nuclear estrogen signaling; Attenuation phase; Estrogen-dependent gene expression; Sema3A PAK dependent Axon repulsion; VEGFR2 mediated vascular permeability; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation; DDX58/IFIH1-mediated induction of interferon-alpha/beta; eNOS activation; HSF1 activation; RHOBTB2 GTPase cycle; Drug-mediated inhibition of ERBB2 signaling | 0.251664970734015 | 1.50457038391225E-17 | 138049.65358917884 | 1606774.576019598 | 6014683.841021903 | 3.5409083660663305 | 1.9043213658945874 |
| Q02819 | Nucleobindin-1 [OS=Mus musculus] | 131.152 | signal transduction | non-structural extracellular;other membranes;ER/Golgi | enzyme regulator activity;nucleic acid binding activity;other molecular function | 18220 | ENSMUSG00000030824 | Nucb1 | mmu:18220; Q02819; Q3TU42; Q9CWA1; Q9D8J4; Q9DBL3 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 0.130903496983571 | 1.50457038391225E-17 | 30635.69892492515 | 2379424.5332984333 | 6548209.148806977 | 6.279255122519686 | 1.460487703830008 | |
| Q91V92 | ATP-citrate synthase [OS=Mus musculus] | 129.973 | other metabolic processes | cytosol | other molecular function | 104112 | ENSMUSG00000020917 | Acly | mmu:104112; Q91V92 | Fatty acid biosynthesis | Neutrophil degranulation; Fatty acyl-CoA biosynthesis | 0.509570119936397 | 0.437429424171984 | 27537.414327710998 | 644183.8162072281 | 1777761.9344937534 | 4.548007409788159 | 1.464517819878004 |
| A2ASQ1 | Agrin [OS=Mus musculus] | 128.989 | cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cell component | signal transduction activity or receptor binding;other molecular function | 11603 | ENSMUSG00000041936 | Agrn | A2ASP9; A2ASQ0; A2ASQ1; B2RWU1 | Primary focal segmental glomerulosclerosis (FSGS) | ECM proteoglycans; Retinoid metabolism and transport; Glycosaminoglycan-protein linkage region biosynthesis; HS-GAG biosynthesis; HS-GAG degradation; Formation of the dystrophin-glycoprotein complex (DGC) | 1.70336894001643E-17 | 1.50457038391225E-17 | 1028829.4241236168 | 2045725.4701757336 | 0.9916087441172836 | ||
| Q61508 | Extracellular matrix protein 1 [OS=Mus musculus] | 127.379 | stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular | signal transduction activity or receptor binding;other molecular function | 13601 | ENSMUSG00000028108 | Ecm1 | mmu:13601; Q3U5Q5; Q61508 | Platelet degranulation | 0.121600547823456 | 1.50457038391225E-17 | 74811.39241511819 | 3515293.344106073 | 1.1331897286900917E7 | 5.554243291002194 | 1.6886724407889737 | |
| Cont_P04259 | Keratin, type II cytoskeletal 6B OS=Homo sapiens OX=9606 GN=KRT6B PE=1 SV=5 | 126.901 | cell organization and biogenesis;other biological processes | cytosol;cytoskeleton | bone, tooth or skin structural activity;cytoskeletal activity | 3854 | ENSG00000185479 | KRT6B | hsa:3854; P04259; P48669 | Formation of the cornified envelope | 0.801271130817871 | 0.758743075163871 | 298970.1410949 | 1115770.6869766254 | 854901.7358096777 | 1.8999672440407571 | -0.3842100469035007 | |
| P17182 | Alpha-enolase [OS=Mus musculus] | 126.804 | other metabolic processes;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;other cell component | nucleic acid binding activity;other molecular function | 13806; 433182 | ENSMUSG00000059040; ENSMUSG00000063524 | Eno1 | mmu:13806; mmu:433182; P17182; Q99KT7; Q9DCY7 | Glycolysis and gluconeogenesis | 1.70336894001643E-17 | 1.50457038391225E-17 | 47358.53377381337 | 1.3905788568310633E7 | 2.89416009584274E7 | 8.19784542826019 | 1.0574591701978524 | |
| P08113 | Endoplasmin [OS=Mus musculus] | 126.346 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cell component | signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function | 22027 | ENSMUSG00000020048 | Hsp90b1 | mmu:22027; P08113; P11427 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Hypoxia-dependent self-renewal of myoblasts | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Scavenging by Class A Receptors; Trafficking and processing of endosomal TLR; Interleukin-4 and Interleukin-13 signaling | 0.205304099107124 | 1.50457038391225E-17 | 52582.03853978356 | 6037105.20140975 | 1.2434595462188734E7 | 6.84314305674472 | 1.0424307261560617 |
| P58252 | Elongation factor 2 [OS=Mus musculus] | 126.048 | cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;translational apparatus;other cell component | cytoskeletal activity;translation activity;nucleic acid binding activity;other molecular function | 13629 | ENSMUSG00000034994 | Eef2 | mmu:13629; P58252; Q544E4 | Translation factors | Neutrophil degranulation; Protein methylation; Peptide chain elongation; Synthesis of diphthamide-EEF2 | 0.84258396038376 | 0.471929633209224 | 229633.38558146535 | 4859646.5618234025 | 1.3065706600835832E7 | 4.40344708092177 | 1.426861851823294 |
| Cont_P02538 | Keratin, type II cytoskeletal 6A OS=Homo sapiens OX=9606 GN=KRT6A PE=1 SV=3 | 123.757 | cell organization and biogenesis;stress response;other biological processes | cytosol;cytoskeleton | bone, tooth or skin structural activity;cytoskeletal activity | 3853 | ENSG00000205420 | KRT6A | A4QPC1; hsa:3853; P02538; P48667; Q08AR4; Q6NT67; Q96CL4 | Ectoderm differentiation; Ectoderm differentiation; Pancreatic cancer subtypes | Formation of the cornified envelope | 0.84258396038376 | 0.745886066139481 | 2182876.549653717 | 8485501.699692694 | 3982846.61307857 | 1.9587694181864725 | -1.0912000408128149 |
| P97298 | Pigment epithelium-derived factor [OS=Mus musculus] | 123.502 | cell cycle OR cell proliferation;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | enzyme regulator activity | 20317 | ENSMUSG00000000753 | Serpinf1 | mmu:20317; O70629; O88691; P97298 | 0.770205086382264 | 0.434748506750565 | 462579.17347644636 | 5921015.69252881 | 1.5757205380580032E7 | 3.6780724587081086 | 1.4120951058109443 | ||
| Q70E20 | Sushi, nidogen and EGF-like domain-containing protein 1 [OS=Mus musculus] | 122.942 | cell adhesion | non-structural extracellular;extracellular matrix | other molecular function | 208777 | Sned1 | A6H6I3; mmu:208777; Q70E20; Q810H2; Q8BMD9 | 1.70336894001643E-17 | 1.50457038391225E-17 | 37861.533059704365 | 4995161.517920501 | 1.4223395042125002E7 | 7.0436546892015075 | 1.5096626357764027 | |||
| P13020 | Gelsolin [OS=Mus musculus] | 122.934 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 227753 | ENSMUSG00000026879 | Gsn | mmu:227753; P13020; Q3UPB1; Q8R590 | Regulation of actin cytoskeleton | Neutrophil degranulation; Caspase-mediated cleavage of cytoskeletal proteins | 0.379422692457324 | 0.186266168629733 | 1139775.9088509877 | 1.1033925013460701E7 | 2.9144067496602204E7 | 3.2751239717088607 | 1.4012561603631017 |
| Q61398 | Procollagen C-endopeptidase enhancer 1 [OS=Mus musculus] | 120.4 | protein metabolism;other biological processes | enzyme regulator activity;other molecular function | 18542 | ENSMUSG00000029718 | Pcolce | mmu:18542; O35113; Q61398 | mRNA processing | Collagen biosynthesis and modifying enzymes; Crosslinking of collagen fibrils | 0.288320039261486 | 0.151224536345852 | 84503.2651712337 | 7672570.19904635 | 1.2538308810459368E7 | 6.504559042639965 | 0.7085609223825361 | |
| P26039 | Talin-1 [OS=Mus musculus] | 118.226 | cell adhesion;cell organization and biogenesis;signal transduction | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;other molecular function | 21894 | ENSMUSG00000028465 | Tln1 | A2AIM8; mmu:21894; P26039; Q8VEF0 | Primary focal segmental glomerulosclerosis (FSGS); Integrin-mediated cell adhesion; Focal adhesion | Platelet degranulation ; MAP2K and MAPK activation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; Smooth Muscle Contraction; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 0.738983404380581 | 0.680632778351053 | 147890.2697082064 | 286851.2614141297 | 2291518.0404973766 | 0.9557757272954962 | 2.997928876406007 |
| Q8BPB5 | EGF-containing fibulin-like extracellular matrix protein 1 [OS=Mus musculus] | 117.738 | protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes | extracellular matrix | signal transduction activity or receptor binding;kinase activity;other molecular function | 216616 | ENSMUSG00000020467 | Efemp1 | mmu:216616; Q6Y3N6; Q8BPB5 | 0.376780684027729 | 1.50457038391225E-17 | 29995.485006469138 | 1370373.3251651835 | 3606517.1409647237 | 5.51367980488993 | 1.396037306430432 | ||
| P09411 | Phosphoglycerate kinase 1 [OS=Mus musculus] | 116.462 | protein metabolism;other metabolic processes;stress response;other biological processes | non-structural extracellular;other membranes;cytosol;mitochondrion;other cell component | kinase activity;other molecular function | 18655 | ENSMUSG00000062070 | Pgk1 | mmu:18655; P09411; Q3TPE6; Q3UKV8; Q5XJE7 | Glycolysis and gluconeogenesis | Gluconeogenesis; Glycolysis | 1.70336894001643E-17 | 1.50457038391225E-17 | 46750.53578358531 | 4500077.619792943 | 1.4795712145397767E7 | 6.588823176749667 | 1.7171573466629246 |
| P27773 | Protein disulfide-isomerase A3 [OS=Mus musculus] | 115.891 | cell adhesion;cell organization and biogenesis;stress response;signal transduction;other biological processes | non-structural extracellular;other membranes;ER/Golgi;other cell component | nucleic acid binding activity;other molecular function | 14827 | ENSMUSG00000027248 | Pdia3 | mmu:14827; P27773; Q3TEI9; Q3TIL2; Q3UZK8; Q8C2F4; Q99LF6 | ER-Phagosome pathway; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Calnexin/calreticulin cycle | 0.874168055361729 | 0.498293621965442 | 196243.61956605766 | 7238345.98431998 | 1.5315044241817234E7 | 5.204942414672023 | 1.0812175609972197 | |
| P10107 | Annexin A1 [OS=Mus musculus] | 115.566 | cell organization and biogenesis;stress response;transport;signal transduction;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component | enzyme regulator activity;other molecular function | 16952 | ENSMUSG00000024659 | Anxa1 | mmu:16952; P10107 | Spinal cord injury; Prostaglandin synthesis and regulation | G alpha (q) signalling events; G alpha (i) signalling events; Formyl peptide receptors bind formyl peptides and many other ligands | 1.70336894001643E-17 | 1.50457038391225E-17 | 8983.410658903753 | 4211649.667813237 | 1.08370832078509E7 | 8.872906434854283 | 1.3635191681000571 |
| Cont_Q2KJF1 | Alpha-1B-glycoprotein OS=Bos taurus OX=9913 GN=A1BG PE=1 SV=1 | 115.502 | signal transduction | non-structural extracellular;plasma membrane;other membranes | 518955 | A1BG | bta:518955; Q2KJF1 | Platelet degranulation ; Neutrophil degranulation | 0.360991986803736 | 0.641514600397631 | 9385194.584847162 | 6762503.63408608 | 1.0317459698123023E7 | -0.4728291927834855 | 0.6094584335875003 | |||
| Cont_Q3MHN5 | Vitamin D-binding protein OS=Bos taurus OX=9913 GN=GC PE=2 SV=1 | 113.599 | other metabolic processes;transport | non-structural extracellular;other cell component | transporter activity;cytoskeletal activity;other molecular function | 530076 | GC | bta:530076; Q3MHN5 | 0.479472599858427 | 0.579435037816218 | 1.2784681703575822E7 | 1.0785165311962552E7 | 1.4618596373270534E7 | -0.24536795278737014 | 0.43875650549577433 | |||
| P17742 | Peptidyl-prolyl cis-trans isomerase A [OS=Mus musculus] | 113.527 | cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes | non-structural extracellular;cytosol;nucleus;other cell component | signal transduction activity or receptor binding;other molecular function | 268373 | ENSMUSG00000071866 | Ppia | mmu:268373; P17742; Q9CWJ5; Q9R137 | Neutrophil degranulation; Basigin interactions | 1.70336894001643E-17 | 1.50457038391225E-17 | 5533917.143041036 | 1.0696784170781441E7 | 4.607074026803666E7 | 0.9508041886121662 | 2.1066736424755597 | |
| Q69ZN7 | Myoferlin [OS=Mus musculus] | 112.647 | cell organization and biogenesis;other metabolic processes;stress response;other biological processes | plasma membrane;other membranes;nucleus | other molecular function | 226101 | ENSMUSG00000048612 | Myof | mmu:226101; Q69ZN7; Q7TMG0; Q80V33; Q8BU64; Q8BU70; Q8BUC1; Q8BVY6; Q8C0D1; Q8R3B4 | 0.930955411749965 | 0.888974672311279 | 74563.786625436 | 1104935.9693987637 | 3065805.015040973 | 3.8893438309545054 | 1.4723031761891572 | ||
| P26041 | Moesin [OS=Mus musculus] | 112.068 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function | 17698 | ENSMUSG00000031207 | Msn | B1AX70; mmu:17698; P26041; Q3UL28; Q8BSN4 | Regulation of actin cytoskeleton | Recycling pathway of L1 | 0.157138696252226 | 1.50457038391225E-17 | 3564499.916018247 | 1.120013397828275E7 | 1.9030746620886367E7 | 1.6517443981180746 | 0.764816172839194 |
| P05064 | Fructose-bisphosphate aldolase A [OS=Mus musculus] | 112.015 | cell organization and biogenesis;other metabolic processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | other molecular function | 11674 | ENSMUSG00000030695 | Aldoa | mmu:11674; P05064 | Glycolysis and gluconeogenesis | Platelet degranulation ; Neutrophil degranulation; Gluconeogenesis; Glycolysis | 0.0771819601934254 | 1.50457038391225E-17 | 21908.055682018665 | 4518789.603964283 | 1.0653934694757948E7 | 7.688331123815105 | 1.2373780513518877 |
| B2RQC6 | Multifunctional protein CAD [OS=Mus musculus] | 111.853 | other metabolic processes;stress response;transport;developmental processes;other biological processes | cytosol;nucleus;other cell component | kinase activity;other molecular function | 69719 | ENSMUSG00000013629 | Cad | B2RQC6; B7ZN27; mmu:69719 | Mechanisms associated with pluripotency | Pyrimidine biosynthesis | 0.963127218853016 | 0.666244110962191 | 34439.61575478624 | 139659.55402474166 | 452794.3373622177 | 2.019773319192686 | 1.6969416450846668 |
| Q8BND5 | Sulfhydryl oxidase 1 [OS=Mus musculus] | 111.186 | cell organization and biogenesis;other biological processes | non-structural extracellular;other membranes;ER/Golgi | other molecular function | 104009 | ENSMUSG00000033684 | Qsox1 | mmu:104009; Q3TDY9; Q3TE19; Q3TR29; Q3UEL4; Q8BND5; Q8K041; Q9DBL6 | Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Neutrophil degranulation | 0.162753188077458 | 1.50457038391225E-17 | 25068.200750320597 | 1818282.5759143168 | 5040172.36278756 | 6.180574161657264 | 1.4708966480504568 |
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| Accession | Description | Sum PEP Score | Biological Process | Cellular Component | Molecular Function | Entrez Gene ID | Ensembl Gene ID | Gene Symbol | Gene ID | WikiPathways | Reactome Pathways | Abundance Ratio Adj. P-Value: (SQ_16h) / (LQ_16h) | Abundance Ratio Adj. P-Value: (SQ_6h) / (LQ_6h) | LQ6h_AVERAGE | LQ16h_AVERAGE | LQ24h_AVERAGE | SQ6h_AVERAGE | SQ16h_AVERAGE | FC_SQ_16_vs_LQ_16h | FC_SQ_6_vs_LQ_6h |
| P11276 | Fibronectin [OS=Mus musculus] | 867.353 | cell adhesion;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi | signal transduction activity or receptor binding;enzyme regulator activity;other molecular function | 14268 | ENSMUSG00000026193 | Fn1 | G5E8B8; mmu:14268; P11276; Q61567; Q61568; Q61569; Q64233; Q80UI4 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Inflammatory response pathway; Regulation of actin cytoskeleton; Comprehensive IL-17A signaling; Focal adhesion | ECM proteoglycans; Platelet degranulation ; Cell surface interactions at the vascular wall; Syndecan interactions; MAP2K and MAPK activation; Integrin cell surface interactions; Molecules associated with elastic fibres; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Fibronectin matrix formation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; Degradation of the extracellular matrix; Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells; MET activates PTK2 signaling; GPER1 signaling | 0.974036928885484 | 0.435823028559966 | 2.022341523870097E8 | 2.12696235413058E8 | 2.684744239015217E8 | 1.2629719382404166E8 | 2.7495824150743634E8 | 0.37041803136358886 | -0.6792040691298411 |
| P11087 | Collagen alpha-1(I) chain [OS=Mus musculus] | 797.017 | cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12842 | ENSMUSG00000001506 | Col1a1 | mmu:12842; P11087; Q53WT0; Q60635; Q61367; Q61427; Q63919; Q6PCL3; Q810J9 | Osteoblast signaling; Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Comprehensive IL-17A signaling; Focal adhesion | Cell surface interactions at the vascular wall; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ECM proteoglycans; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; GPVI-mediated activation cascade; GP1b-IX-V activation signalling; Platelet Adhesion to exposed collagen; Platelet Aggregation (Plug Formation); MET activates PTK2 signaling | 1.58880673198775E-4 | 0.0629214061377862 | 2.0798706453114033E8 | 5.92854376184685E8 | 5.928171930552336E8 | 5.973622733379293E7 | 8.428319253806247E7 | -2.814360908962058 | -1.799815773091645 |
| Q01149 | Collagen alpha-2(I) chain [OS=Mus musculus] | 773.662 | cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12843 | ENSMUSG00000029661 | Col1a2 | mmu:12843; Q01149; Q8CGA5 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Focal adhesion | Crosslinking of collagen fibrils; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; ECM proteoglycans; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; GPVI-mediated activation cascade; GP1b-IX-V activation signalling; Platelet Adhesion to exposed collagen; Platelet Aggregation (Plug Formation); MET activates PTK2 signaling | 0.0150838661305169 | 0.0347692006632991 | 1.7308392932505235E8 | 3.475967473053053E8 | 4.108532345040607E8 | 4.271481968913147E7 | 9.036410240893161E7 | -1.9435929082069783 | -2.018663180583724 |
| P08121 | Collagen alpha-1(III) chain [OS=Mus musculus] | 695.631 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | extracellular matrix;other cell component | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 12825 | ENSMUSG00000026043 | Col3a1 | mmu:12825; P08121; Q61429; Q9CRN7 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Inflammatory response pathway; Focal adhesion | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ECM proteoglycans; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; MET activates PTK2 signaling | 0.00738207855214502 | 0.394949139624895 | 6.282890624937943E7 | 2.8394661715058166E8 | 2.9634851273536664E8 | 3.0365458724261332E7 | 6.6157215803336866E7 | -2.101649298329015 | -1.0489973014656733 |
| Q9QXS1 | Plectin [OS=Mus musculus] | 659.702 | cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component | cytoskeletal activity;other molecular function | 18810 | ENSMUSG00000022565 | Plec | E9QN87; mmu:18810; Q6S384; Q6S389; Q6S394; Q9CS65; Q9QUT2; Q9QXQ8; Q9QXQ9; Q9QXR0; Q9QXR1; Q9QXR2; Q9QXR3; Q9QXR4; Q9QXR5; Q9QXR6; Q9QXR7; Q9QXR8; Q9QXR9; Q9QXS0; Q9QXS1; Q9QXS2; Q9QXS3 | Alpha 6 beta 4 integrin signaling pathway; EGFR1 signaling pathway | Type I hemidesmosome assembly; Caspase-mediated cleavage of cytoskeletal proteins | 0.850917681937748 | 0.702330308974487 | 4599273.114185064 | 1.6676006673579365E7 | 4.0231485359460294E7 | 1.01501282886872E7 | 4.28490141732006E7 | 1.3614881580387048 | 1.1420201863832355 |
| P08122 | Collagen alpha-2(IV) chain [OS=Mus musculus] | 526.992 | RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix | extracellular structural activity | 12827 | ENSMUSG00000031503 | Col4a2 | mmu:12827; P08122; Q3B7C2; Q3TPV9; Q61375; Q66JS5; Q6RCT6; Q6RCT7; Q6U9X1; Q8BPI9; Q8BPK3; Q91VI3 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Focal adhesion | Laminin interactions; Signaling by PDGF; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions | 0.979628232635575 | 0.959159975702413 | 1.3981747232493034E7 | 5.0194805286054574E7 | 9.68446240720073E7 | 1.701609057115766E7 | 5.972856146483746E7 | 0.25088290969327387 | 0.2833549587108298 |
| Q3U962 | Collagen alpha-2(V) chain [OS=Mus musculus] | 518.514 | cell organization and biogenesis;developmental processes;other biological processes | extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12832 | ENSMUSG00000026042 | Col5a2 | mmu:12832; Q3TVR2; Q3U962; Q3UHK7; Q3UTT4; Q3V1J6; Q61431; Q7TMS0; Q80VS8 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions | 0.0769666553885184 | 0.453486790198347 | 1.5753424919239333E7 | 4.592471970087584E7 | 6.332560400994137E7 | 1.0471363011153279E7 | 2.1079551940947264E7 | -1.1234267140336414 | -0.5892162722872147 |
| Q05793 | Basement membrane-specific heparan sulfate proteoglycan core protein [OS=Mus musculus] | 507.28 | cell organization and biogenesis;transport;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;ER/Golgi | other molecular function | 15530 | Hspg2 | mmu:15530; Q05793 | 0.208890689478245 | 0.285967432697218 | 2.1355561683383033E7 | 4.109385814368304E7 | 4.603208822128189E7 | 8244737.341084313 | 1.8998181152407136E7 | -1.1130614814811859 | -1.373066405061947 | |||
| Q61554 | Fibrillin-1 [OS=Mus musculus] | 499.202 | cell adhesion;other metabolic processes;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 14118 | ENSMUSG00000027204 | Fbn1 | A2AQ53; mmu:14118; Q60826; Q61554 | Comprehensive IL-17A signaling | Integrin cell surface interactions; Degradation of the extracellular matrix; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; TGF-beta receptor signaling activates SMADs; Molecules associated with elastic fibres | 0.087482121441914 | 0.0455630470425967 | 2.17735814942991E7 | 5.216417896597137E7 | 4.48746709774994E7 | 5145074.9913376765 | 2.082557122129057E7 | -1.3247033834999922 | -2.0813147229720497 |
| Q8BTM8 | Filamin-A [OS=Mus musculus] | 493.069 | cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;other molecular function | 192176 | ENSMUSG00000031328 | Flna | B7FAV0; O54934; Q7TQI1; Q8BLK1; Q8BTM8; Q8BTN7; Q8VHX5; Q8VHX8; Q99KQ2 | Mapk signaling pathway; Focal adhesion | Platelet degranulation ; Cell-extracellular matrix interactions; RHO GTPases activate PAKs; GP1b-IX-V activation signalling | 0.946239447314336 | 0.904360680536565 | 4952287.405198824 | 1.1395384793048913E7 | 3.45895898091015E7 | 4296604.098486893 | 1.4686023116833666E7 | 0.36599413443703693 | -0.20489819440782575 |
| P02463 | Collagen alpha-1(IV) chain [OS=Mus musculus] | 487.707 | cell organization and biogenesis;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix | extracellular structural activity;other molecular function | 12826 | ENSMUSG00000031502 | Col4a1 | mmu:12826; P02463; Q3UHJ4; Q3UJE7; Q3UQV2; Q53X35; Q6GQS7; Q6PHB5; Q99LQ8 | Spinal cord injury; Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Laminin interactions; Signaling by PDGF; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions | 0.483508479481234 | 0.777395712279767 | 4620515.057112186 | 2.1463797748519864E7 | 4.45598479783772E7 | 8911949.32392111 | 3.3156314746725336E7 | 0.627378297898211 | 0.9476873486816851 |
| Q60847 | Collagen alpha-1(XII) chain [OS=Mus musculus] | 480.266 | cell adhesion;developmental processes | other cell component | 12816 | ENSMUSG00000032332 | Col12a1 | mmu:12816; P70322; Q60847 | Assembly of collagen fibrils and other multimeric structures; Collagen chain trimerization; Collagen degradation | 0.119424004207039 | 0.0103905836841461 | 5.1736330625803865E7 | 2.9952489655588504E7 | 5.41828161343536E7 | 1.0537780206453351E7 | 1.4629541968462234E7 | -1.033791323716814 | -2.2956067413237813 | ||
| Q8VDD5 | Myosin-9 [OS=Mus musculus] | 418.364 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;stress response;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;other molecular function | 17886 | ENSMUSG00000022443 | Myh9 | mmu:17886; Q3UHT9; Q3UHU4; Q6KAN6; Q811I2; Q8VDD5 | Primary focal segmental glomerulosclerosis (FSGS) | RHO GTPases activate PAKs; Regulation of actin dynamics for phagocytic cup formation | 0.87421335771164 | 0.91728043005175 | 5176534.940650649 | 8067345.413832072 | 1.95000780331961E7 | 7844465.70271172 | 1.9759662960152034E7 | 1.2923924059140754 | 0.5996884741558165 |
| Cont_P02453 | Collagen alpha-1(I) chain OS=Bos taurus OX=9913 GN=COL1A1 PE=1 SV=3 | 414.689 | cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | 282187 | ENSBTAG00000013103 | COL1A1 | bta:282187; P02453; Q3MHM2 | Inflammatory response pathway; Osteoblast signaling; Focal adhesion | Fibronectin matrix formation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Collagen degradation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; Collagen chain trimerization; GPVI-mediated activation cascade; Platelet Aggregation (Plug Formation); Platelet Adhesion to exposed collagen; GP1b-IX-V activation signalling | 0.067749585016969 | 0.108042253370914 | 3262486.7198886867 | 3910059.36528234 | 2611857.205675677 | 1102058.9569362423 | 924822.5329095138 | -2.079942057680374 | -1.5657706231882562 |
| Cont_P02769 | Albumin OS=Bos taurus OX=9913 GN=ALB PE=1 SV=4 | 390.555 | stress response;other biological processes | non-structural extracellular;other cell component | nucleic acid binding activity;other molecular function | 280717 | ALB | A5PJX3; bta:280717; O02787; P02769; P04277; Q3SZR2 | 0.946568086066385 | 0.846117085258013 | 2.9099571807541137E9 | 2.4034772237737E9 | 1.9319093626168566E9 | 2.38097622607819E9 | 2.6841204207378564E9 | 0.15932626621701673 | -0.28944470896955565 | |||
| P01027 | Complement C3 [OS=Mus musculus] | 388.541 | cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular;other cell component | signal transduction activity or receptor binding;enzyme regulator activity | 12266 | ENSMUSG00000024164 | C3 | mmu:12266; P01027; Q61370; Q80XP1 | Complement activation, classical pathway; Tyrobp causal network in microglia; Comprehensive IL-17A signaling | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade; Neutrophil degranulation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; G alpha (i) signalling events; Peptide ligand-binding receptors; Alternative complement activation; Activation of C3 and C5 | 0.939492000987438 | 0.413470300505934 | 1.6657146132333001E7 | 4.4549110086954266E7 | 9.444511683907779E7 | 3.6733221642207734E7 | 8.026680998659676E7 | 0.8494069495035886 | 1.1409441863835255 |
| Cont_Q7SIH1 | Alpha-2-macroglobulin OS=Bos taurus OX=9913 GN=A2M PE=1 SV=2 | 370.864 | non-structural extracellular | enzyme regulator activity;other molecular function | 513856 | ENSBTAG00000018137 | A2M | A8E647; bta:513856; Q7SIH1 | IL-6 signaling pathway | 0.944154202827561 | 0.671798309985569 | 7.564994624258716E7 | 7.018676700369896E7 | 1.6376415758098435E8 | 5.23492843648457E7 | 8.250822323914327E7 | 0.23333886293366002 | -0.5311692421661273 | ||
| Cont_Q29443 | Serotransferrin OS=Bos taurus OX=9913 GN=TF PE=2 SV=1 | 343.183 | stress response;transport;other biological processes | non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle | other molecular function | 280705 | TF | bta:280705; Q0IIK2; Q29443 | 0.902231721267411 | 0.506704636011438 | 2.32106703986673E8 | 1.5606409762411097E8 | 1.0552713551758902E8 | 1.3567523181654152E8 | 1.6257112433260167E8 | 0.058932345527944796 | -0.7746308192572785 | |||
| Cont_P07589 | Fibronectin OS=Bos taurus OX=9913 GN=FN1 PE=1 SV=4 | 337.517 | cell adhesion;cell organization and biogenesis;stress response;developmental processes;other biological processes | non-structural extracellular | signal transduction activity or receptor binding;other molecular function | FN1 | P07589 | 0.553450172742796 | 0.35834247597224 | 835883.8306505851 | 952169.9232567847 | 590914.7645248 | 482619.7682389803 | 602598.7403397557 | -0.6600214012146457 | -0.7924154436110592 | ||||
| Q80X90 | Filamin-B [OS=Mus musculus] | 335.882 | cell organization and biogenesis;stress response;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 286940 | ENSMUSG00000025278 | Flnb | E9QNV9; mmu:286940; Q80X90; Q8VHX4; Q8VHX7; Q99KY3 | ISG15 antiviral mechanism | 0.936411452199724 | 0.872448101434609 | 2351112.5534752235 | 6048828.490809467 | 1.7547066707595836E7 | 1865154.4144755967 | 7592568.170254476 | 0.3279322018375229 | -0.3340485310994022 | |
| Cont_P35527 | Keratin, type I cytoskeletal 9 OS=Homo sapiens OX=9606 GN=KRT9 PE=1 SV=3 | 310.424 | cell organization and biogenesis;other biological processes | cytosol;cytoskeleton | cytoskeletal activity | 3857 | ENSG00000171403 | KRT9 | hsa:3857; O00109; P35527; Q0IJ47; Q14665 | Formation of the cornified envelope | 0.873609880131656 | 0.516448827835279 | 3.250630567014273E7 | 4.1318104811136335E7 | 3.4478974092312835E7 | 9.369998400542612E7 | 5.1433611479478456E7 | 0.31593737616513196 | 1.5273291980404673 | |
| Cont_P04264 | Keratin, type II cytoskeletal 1 OS=Homo sapiens OX=9606 GN=KRT1 PE=1 SV=6 | 306.58 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;other molecular function | 3848 | ENSG00000167768 | KRT1 | B2RA01; hsa:3848; P04264; P85925; P86104; Q14720; Q6GSJ0; Q9H298 | Corticotropin-releasing hormone signaling | Formation of the cornified envelope; Neutrophil degranulation; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.873609880131656 | 0.254077056479593 | 1.3414412508194733E8 | 1.6528138436319932E8 | 1.1322276749996448E8 | 4.476405570139613E8 | 1.7631437693719265E8 | 0.09322587587347089 | 1.738556880584629 |
| P06909 | Complement factor H [OS=Mus musculus] | 292.01 | cell adhesion;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes | non-structural extracellular;plasma membrane;other membranes;mitochondrion;other cell component | other molecular function | 12628 | ENSMUSG00000026365 | Cfh | mmu:12628; P06909; Q6NZK3 | Regulation of Complement cascade | 0.678323397545056 | 0.750662231008662 | 1.0566840244224759E7 | 1.036081717107911E7 | 1.3701110968154365E7 | 8439848.284125684 | 2.9357524779450033E7 | 1.502592540643395 | -0.3242550682599269 | |
| P16546 | Spectrin alpha chain, non-erythrocytic 1 [OS=Mus musculus] | 291.854 | cell organization and biogenesis | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 20740 | ENSMUSG00000057738 | Sptan1 | A3KGU6; A3KGU8; P16546; Q8K380; Q9CT05 | FAS pathway and stress induction of HSP regulation | Neutrophil degranulation; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Interaction between L1 and Ankyrins; COPI-mediated anterograde transport; RHOU GTPase cycle; RHOV GTPase cycle; Caspase-mediated cleavage of cytoskeletal proteins | 0.929383260195332 | 0.870511801558508 | 1427277.73205798 | 3976922.979229001 | 9978258.42723309 | 2263434.85725903 | 8138355.29233573 | 1.0330846429966014 | 0.6652476915056309 |
| Cont_P13645 | Keratin, type I cytoskeletal 10 OS=Homo sapiens OX=9606 GN=KRT10 PE=1 SV=6 | 286.713 | cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes | plasma membrane;cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;other molecular function | 3858 | ENSG00000186395 | KRT10 | hsa:3858; P13645; Q14664; Q8N175 | Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.829734761131295 | 0.246231694954624 | 9.409796786421584E7 | 1.13950700113199E8 | 6.71694026550819E7 | 3.19749190691826E8 | 1.0914077913761683E8 | -0.06221954053344878 | 1.7647052355257151 | |
| Cont_P35908 | Keratin, type II cytoskeletal 2 epidermal OS=Homo sapiens OX=9606 GN=KRT2 PE=1 SV=2 | 284.975 | cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes | plasma membrane;cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;cytoskeletal activity | 3849 | ENSG00000172867 | KRT2 | hsa:3849; P35908; Q4VAQ2 | Formation of the cornified envelope | 0.912218866069753 | 0.309041843038519 | 2.9357809740500167E7 | 3.415287514761583E7 | 1.8123682357997265E7 | 7.640800383787991E7 | 3.617272663897294E7 | 0.0828953136099207 | 1.3799794314161524 | |
| Q62059 | Versican core protein [OS=Mus musculus] | 279.715 | cell adhesion;developmental processes | non-structural extracellular;extracellular matrix;other cell component | other molecular function | Vcan | Q62058; Q62059; Q9CUU0 | ECM proteoglycans; Glycosaminoglycan-protein linkage region biosynthesis; CS/DS degradation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; CS-GAG biosynthesis; DS-GAG biosynthesis | 0.854305439376382 | 0.478009151463064 | 9.037034497028168E7 | 9.467651077277745E7 | 6.45815395615126E7 | 5.89459061512507E7 | 9.510262638582683E7 | 0.006478645904816274 | -0.6164578097523755 | |||
| P10493 | Nidogen-1 [OS=Mus musculus] | 275.191 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | other molecular function | 18073 | ENSMUSG00000005397 | Nid1 | mmu:18073; P10493; Q3TKX9; Q8BQI3; Q8C3U8; Q8C9P6 | Laminin interactions; Degradation of the extracellular matrix | 0.013229256333524 | 1.0740690550749E-5 | 1.2120394496125467E8 | 1.2671518083095133E8 | 1.3280012723821335E8 | 9146738.193898173 | 3.1971627034095198E7 | -1.9867253039502062 | -3.7280354888144775 | |
| O88207 | Collagen alpha-1(V) chain [OS=Mus musculus] | 275.025 | cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes | extracellular matrix;other cell component | extracellular structural activity;other molecular function | 12831 | ENSMUSG00000026837 | Col5a1 | A3KGE3; mmu:12831; O88207; Q3UG94; Q6F6B0 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | ECM proteoglycans; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation; Fibronectin matrix formation; Non-integrin membrane-ECM interactions; MET activates PTK2 signaling | 0.189625712887896 | 0.302671730722046 | 3577832.3612721 | 8562033.320911517 | 1.35263273373913E7 | 1386447.3981625708 | 3098568.0509616495 | -1.4663517968660993 | -1.367692910200405 |
| P37889 | Fibulin-2 [OS=Mus musculus] | 269.894 | other biological processes | non-structural extracellular | other molecular function | 14115 | ENSMUSG00000064080 | Fbln2 | G5E8B3; mmu:14115; P37889; Q9WUI2 | Molecules associated with elastic fibres | 0.453005417011507 | 0.290132264062119 | 6.556805587417743E7 | 8.021475911820169E7 | 7.423633042764436E7 | 3.00676966042863E7 | 4.93487108032657E7 | -0.700855313955825 | -1.1247787672414093 | |
| Q8VHX6 | Filamin-C [OS=Mus musculus] | 249.498 | cell organization and biogenesis;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity | 68794 | ENSMUSG00000068699 | Flnc | B2RY80; B9EKT2; mmu:68794; Q6PAI6; Q8VHX6; Q9JJ38 | Cell-extracellular matrix interactions | 0.976873891151678 | 0.933437821008547 | 1016453.1391661359 | 2089599.8263247435 | 6137929.999733508 | 1136666.5742976035 | 4459384.47065665 | 1.093617906439173 | 0.1612654161431754 | |
| Q04857 | Collagen alpha-1(VI) chain [OS=Mus musculus] | 248.981 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component | other molecular function | 12833 | ENSMUSG00000001119 | Col6a1 | mmu:12833; Q04857 | ECM proteoglycans; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; Collagen chain trimerization; Collagen degradation; Signaling by PDGF; NCAM1 interactions | 0.0353343473113635 | 0.115965329440656 | 5.0068940213435836E7 | 6.914260176814564E7 | 6.089353622953653E7 | 1.4473176745930666E7 | 1.9886194591010433E7 | -1.7978076624001023 | -1.7905343022837863 | |
| Cont_Q2UVX4 | Complement C3 OS=Bos taurus OX=9913 GN=C3 PE=1 SV=2 | 247.154 | cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular;other cell component | signal transduction activity or receptor binding;enzyme regulator activity | 280677 | ENSBTAG00000017280 | C3 | bta:280677; Q2KIZ4; Q2UVX4 | Complement and coagulation cascades; Complement activation, classical pathway | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Neutrophil degranulation; Peptide ligand-binding receptors; G alpha (i) signalling events; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade; Alternative complement activation; Activation of C3 and C5 | 0.87421335771164 | 0.591028379533681 | 1.84550126489547E7 | 1.5291804049274266E7 | 1.004110180479193E7 | 1.196234797265725E7 | 1.6127794015790733E7 | 0.07679049940163296 | -0.6255121365240285 |
| Q62261 | Spectrin beta chain, non-erythrocytic 1 [OS=Mus musculus] | 244.684 | cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 20742 | ENSMUSG00000020315 | Sptbn1 | A2AFU1; mmu:20742; Q3TEM7; Q5SQL8; Q5SQL9; Q62261; Q9QWJ7 | COPI-mediated anterograde transport; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; RHOU GTPase cycle; Interaction between L1 and Ankyrins; RHOV GTPase cycle | 0.937876734191067 | 0.664971370235365 | 920886.7046363313 | 2921004.358024217 | 7076390.486598223 | 2299979.2063157237 | 6417771.720584608 | 1.1356079634194152 | 1.3205252384353656 | |
| Q640N1 | Adipocyte enhancer-binding protein 1 [OS=Mus musculus] | 239.707 | protein metabolism;other biological processes | nucleus;other cell component | nucleic acid binding activity;other molecular function | 11568 | ENSMUSG00000020473 | Aebp1 | mmu:11568; O88442; Q3TVV5; Q3TWA7; Q3TX56; Q3TXB2; Q5NCI9; Q61281; Q640N1 | 0.534291750451691 | 0.145805028390539 | 3.9556778473622136E7 | 4.1143769603117764E7 | 4.694818678152809E7 | 1.8648394999714002E7 | 3.1901344171106894E7 | -0.3670567664350577 | -1.0848734687320578 | ||
| P57780 | Alpha-actinin-4 [OS=Mus musculus] | 239.42 | cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes | cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 60595 | ENSMUSG00000054808 | Actn4 | mmu:60595; P57780 | Primary focal segmental glomerulosclerosis (FSGS) | Platelet degranulation | 0.921882153462399 | 0.968364585136618 | 4580996.01302682 | 9830280.285985528 | 3.01659424163415E7 | 4440337.50144963 | 1.1658414413951913E7 | 0.24606713307090775 | -0.044991970039703705 |
| Q7TPR4 | Alpha-actinin-1 [OS=Mus musculus] | 235.529 | cell adhesion;cell organization and biogenesis;other biological processes | plasma membrane;other membranes;cytoskeleton;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function | 109711 | ENSMUSG00000015143 | Actn1 | mmu:109711; Q7TPR4 | Regulation of actin cytoskeleton; Integrin-mediated cell adhesion; Focal adhesion | Platelet degranulation ; RHOF GTPase cycle; RHOBTB2 GTPase cycle; RHOD GTPase cycle; Regulation of cytoskeletal remodeling and cell spreading by IPP complex components | 0.974207409660283 | 0.837231569641376 | 2525588.7379033365 | 6210475.170240924 | 1.99706831247943E7 | 3717490.65968503 | 9946958.94260729 | 0.679551866892813 | 0.5577093849474224 |
| P02468 | Laminin subunit gamma-1 [OS=Mus musculus] | 230.882 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | extracellular structural activity;other molecular function | Lamc1 | P02468 | 0.3041568870489 | 0.368062651583427 | 7327169.184632126 | 1.61740059690847E7 | 2.6285654209548533E7 | 3246292.9185144133 | 7951596.802164167 | -1.0243605391840713 | -1.1744627453696188 | ||||
| Q91ZX7 | Prolow-density lipoprotein receptor-related protein 1 [OS=Mus musculus] | 230.497 | other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;other molecular function | 16971 | Lrp1 | mmu:16971; Q61291; Q91ZX7; Q920Y4 | Statin pathway; Wnt signaling pathway | Scavenging of heme from plasma; Retinoid metabolism and transport | 0.687557067265551 | 0.74148782464906 | 3548407.5296101067 | 7355877.025944923 | 9948732.886846773 | 2243610.9879279765 | 5724840.5342227295 | -0.3616618538572069 | -0.6613491570014096 | |
| Cont_P60712 | Actin, cytoplasmic 1 OS=Bos taurus OX=9913 GN=ACTB PE=1 SV=1 | 225.45 | cell organization and biogenesis;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component | enzyme regulator activity;cytoskeletal activity;other molecular function | 100033878; 100135470; 100173832; 101844587; 102139853; 11461; 118833809; 280979; 396526; 403580; 414396; 443052; 450133; 60; 81822 | ENSBTAG00000026199; ENSCAFG00000016020; ENSCAFG00030015381; ENSCAFG00040015695; ENSCPOG00000013467; ENSG00000075624; ENSMAUG00000008763; ENSMUSG00000029580; ENSOARG00040012985; ENSOARG00180022443; ENSOARG00185023855; ENSOARG00215030140; ENSOARG00225009314; ENSPPYG00000017336; ENSPTRG00000018890; ENSRNOG00000034254; ENSSSCG00000007585; ENSSSCG00030003451; ENSSSCG00035038792; ENSSSCG00040049462; ENSSSCG00045027458; ENSSSCG00050065025; ENSSSCG00055012597; ENSSSCG00060019124; ENSSSCG00065037921; ENSSSCG00070011353; ENSSSCG00105030144; ENSSSCG00110026965; ENSSSCG00115013637; ENSSSCG00130033784 | Actb; ACTB | A5D961; A5PKA1; bta:280979; cfa:403580; cpoc:100135470; csab:103246953; ecb:100033878; gga:396526; hsa:60; maua:101844587; mmu:11461; O18840; oas:443052; P02570; P60706; P60707; P60708; P60709; P60710; P60711; P60712; P60713; P70514; P99021; pon:100173832; ptr:450133; Q11209; Q11211; Q3SZD2; Q3TI89; Q3TVP6; Q4L0Y2; Q4R561; Q5R1X3; Q5R582; Q5R6G0; Q64316; Q6QAQ1; Q6ZWM3; Q711N9; Q71FK5; Q75MN2; Q76N69; Q8MIJ0; Q8SPX4; Q95164; Q96B34; Q96HG5; rno:81822; ssc:414396 | FAS pathway and stress induction of HSP regulation; Actin cytoskeleton regulation; Myometrial relaxation and contraction pathways; Focal adhesion; Arrhythmogenic right ventricular cardiomyopathy; Pathogenic Escherichia coli infection; Common pathways underlying drug addiction; Myometrial relaxation and contraction pathways; Focal adhesion; Fas ligand pathway and stress induction of heat shock proteins; Pathogenic Escherichia coli infection; Arrhythmogenic right ventricular cardiomyopathy; Focal adhesion; Myometrial relaxation and contraction pathways; Regulation of actin cytoskeleton; Myometrial relaxation and contraction pathways; Ebola virus infection in host; Acute viral myocarditis; Thermogenesis; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Overlap between signal transduction pathways contributing to LMNA laminopathies; Pleural mesothelioma; Regulation of actin cytoskeleton; Network map of SARS-CoV-2 signaling; Regulation of actin cytoskeleton; Regulation of actin cytoskeleton; Focal adhesion | Formation of the canonical BAF (cBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); Regulation of actin dynamics for phagocytic cup formation; EPH-ephrin mediated repulsion of cells; Formation of annular gap junctions; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; RHO GTPases Activate Formins; RHOF GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; B-WICH complex positively regulates rRNA expression; Regulation of CDH1 Function; Formation of the dystrophin-glycoprotein complex (DGC); Formation of the canonical BAF (cBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); RHO GTPases Activate WASPs and WAVEs; UCH proteinases; DNA Damage Recognition in GG-NER; Formation of the non-canonical BAF (ncBAF) complex; RHO GTPases activate IQGAPs; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Cell-extracellular matrix interactions; MAP2K and MAPK activation; Interaction between L1 and Ankyrins; RHOF GTPase cycle; DNA Damage Recognition in GG-NER; MAP2K and MAPK activation; RHO GTPases Activate Formins; Clathrin-mediated endocytosis; UCH proteinases; RHOF GTPase cycle; DNA Damage Recognition in GG-NER; EPH-ephrin mediated repulsion of cells; VEGFA-VEGFR2 Pathway; Regulation of actin dynamics for phagocytic cup formation; Adherens junctions interactions; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); RHO GTPases Activate WASPs and WAVEs; B-WICH complex positively regulates rRNA expression; Regulation of CDH1 Function; EPHB-mediated forward signaling; Formation of the non-canonical BAF (ncBAF) complex; Formation of the canonical BAF (cBAF) complex; Formation of annular gap junctions; RHO GTPases activate IQGAPs; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; RHO GTPases Activate WASPs and WAVEs; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RHO GTPases activate IQGAPs; RHO GTPases Activate Formins; RHOF GTPase cycle; Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs); B-WICH complex positively regulates rRNA expression; Signaling by BRAF and RAF1 fusions; UCH proteinases; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; VEGFA-VEGFR2 Pathway; Formation of the dystrophin-glycoprotein complex (DGC); Factors involved in megakaryocyte development and platelet production; Regulation of MITF-M-dependent genes involved in pigmentation; Formation of the canonical BAF (cBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); EPH-ephrin mediated repulsion of cells; HATs acetylate histones; Interaction between L1 and Ankyrins; Prefoldin mediated transfer of substrate to CCT/TriC; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Adherens junctions interactions; Regulation of CDH1 Function; Formation of the non-canonical BAF (ncBAF) complex; DNA Damage Recognition in GG-NER; Formation of the polybromo-BAF (pBAF) complex; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Formation of annular gap junctions; Folding of actin by CCT/TriC; Cell-extracellular matrix interactions; MAP2K and MAPK activation; RHO GTPases Activate Formins; Recycling pathway of L1; RHO GTPases activate IQGAPs; Clathrin-mediated endocytosis; Formation of the dystrophin-glycoprotein complex (DGC); EPHB-mediated forward signaling; UCH proteinases; B-WICH complex positively regulates rRNA expression; Adherens junctions interactions; Formation of the non-canonical BAF (ncBAF) complex; Formation of annular gap junctions; Formation of the polybromo-BAF (pBAF) complex; VEGFA-VEGFR2 Pathway; Cell-extracellular matrix interactions; RHO GTPases Activate WASPs and WAVEs; Regulation of CDH1 Function; Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; UCH proteinases; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); Formation of the polybromo-BAF (pBAF) complex; B-WICH complex positively regulates rRNA expression; DNA Damage Recognition in GG-NER; Formation of the canonical BAF (cBAF) complex; RHO GTPases Activate Formins; Regulation of CDH1 Function; Interaction between L1 and Ankyrins; RHOF GTPase cycle; Formation of the non-canonical BAF (ncBAF) complex; Adherens junctions interactions; Formation of the dystrophin-glycoprotein complex (DGC); VEGFA-VEGFR2 Pathway; RHO GTPases Activate WASPs and WAVEs; Cell-extracellular matrix interactions; EPHB-mediated forward signaling; MAP2K and MAPK activation; Recycling pathway of L1; RHO GTPases activate IQGAPs; Formation of annular gap junctions; B-WICH complex positively regulates rRNA expression; UCH proteinases; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF); MAP2K and MAPK activation; Formation of the polybromo-BAF (pBAF) complex; RHO GTPases Activate Formins; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases Activate WASPs and WAVEs; Formation of the dystrophin-glycoprotein complex (DGC); VEGFA-VEGFR2 Pathway; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; DNA Damage Recognition in GG-NER; RHOF GTPase cycle; Cell-extracellular matrix interactions; Adherens junctions interactions; Formation of the non-canonical BAF (ncBAF) complex; Formation of the canonical BAF (cBAF) complex; RHO GTPases activate IQGAPs; Regulation of CDH1 Function; Gap junction degradation; Formation of annular gap junctions; Regulation of actin dynamics for phagocytic cup formation; RHOF GTPase cycle; Clathrin-mediated endocytosis; RHO GTPases Activate Formins; Cell-extracellular matrix interactions; VEGFA-VEGFR2 Pathway; Adherens junctions interactions; RHO GTPases activate IQGAPs; UCH proteinases; EPHB-mediated forward signaling; MAP2K and MAPK activation; RHO GTPases Activate WASPs and WAVEs; Formation of the dystrophin-glycoprotein complex (DGC); Formation of annular gap junctions; Formation of the canonical BAF (cBAF) complex; Formation of the polybromo-BAF (pBAF) complex; Formation of the embryonic stem cell BAF (esBAF) complex; Formation of the non-canonical BAF (ncBAF) complex; Regulation of CDH1 Function | 0.946568086066385 | 0.963278515868644 | 4.828873920581084E7 | 6.5074451419171505E7 | 1.9003581889821532E8 | 5.335770948168167E7 | 1.0984219759318356E8 | 0.7552692448247239 | 0.14400994044310264 |
| P63260 | Actin, cytoplasmic 2 [OS=Mus musculus] | 217.791 | cell organization and biogenesis;stress response;developmental processes;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 11465 | ENSMUSG00000062825 | Actg1 | mmu:11465; P02571; P14104; P63260; P99022 | Myometrial relaxation and contraction pathways; Regulation of actin cytoskeleton; Focal adhesion | Platelet degranulation ; RHO GTPases activate IQGAPs; Adherens junctions interactions; Regulation of CDH1 Function; RHO GTPases Activate Formins; Regulation of actin dynamics for phagocytic cup formation; Interaction between L1 and Ankyrins; MAP2K and MAPK activation; Recycling pathway of L1; Clathrin-mediated endocytosis; Formation of the dystrophin-glycoprotein complex (DGC); EPHB-mediated forward signaling; RHOF GTPase cycle; Formation of annular gap junctions; VEGFA-VEGFR2 Pathway; Cell-extracellular matrix interactions; RHO GTPases Activate WASPs and WAVEs; RHOBTB2 GTPase cycle | 0.85271451854395 | 0.731487178650893 | 145698.54484736864 | 254666.434448248 | 751276.7484437827 | 126248.83655432604 | 256671.2110968777 | 0.011312666587244136 | -0.20671637589735362 |
| P33434 | 72 kDa type IV collagenase [OS=Mus musculus] | 212.03 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes | extracellular matrix;plasma membrane;other membranes;cytoskeleton;mitochondrion;nucleus;other cell component | other molecular function | 17390 | ENSMUSG00000031740 | Mmp2 | mmu:17390; P33434 | Lung fibrosis; IL-3 signaling pathway; Matrix metalloproteinases | Collagen degradation; Extra-nuclear estrogen signaling; EPH-ephrin mediated repulsion of cells; Activation of Matrix Metalloproteinases | 0.993994198406889 | 0.34519376377552 | 2.11513119484971E7 | 6.116415043649567E7 | 9.997674520202683E7 | 5.359802560613743E7 | 8.73371018908004E7 | 0.5139083514604432 | 1.3414327051154107 |
| P19096 | Fatty acid synthase [OS=Mus musculus] | 203.372 | other metabolic processes;stress response;other biological processes | plasma membrane;other membranes;cytosol;ER/Golgi;other cell component | other molecular function | 14104 | ENSMUSG00000025153 | Fasn | B1ATU8; mmu:14104; P19096; Q6PB72; Q8C4Z0; Q9EQR0 | Fatty acid biosynthesis; Dysregulated miRNA targeting in insulin/PI3K-AKT signaling; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-9 fatty acid synthesis; Elongation of (very) long chain fatty acids | Fatty acyl-CoA biosynthesis; Vitamin B5 (pantothenate) metabolism | 0.87421335771164 | 0.746782404466558 | 1389784.0897720233 | 2729524.669883373 | 1.0491585001659483E7 | 892753.3234074336 | 2995475.6339221266 | 0.1341353617926422 | -0.6385272655543875 |
| Cont_Q3SZ57 | Alpha-fetoprotein OS=Bos taurus OX=9913 GN=AFP PE=2 SV=1 | 202.89 | other metabolic processes;developmental processes;other biological processes | non-structural extracellular;other cell component | other molecular function | 506011 | ENSBTAG00000017131 | AFP | bta:506011; Q3SZ57 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 0.938859506774495 | 0.699570390946254 | 4.5317948160280704E7 | 3.6151020512819335E7 | 2.37647047257016E7 | 3.679174310656657E7 | 4.2915740009991035E7 | 0.2474705016386588 | -0.30070051296273864 | |
| P48678 | Prelamin-A/C [OS=Mus musculus] | 202.607 | cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes | other membranes;cytoskeleton;nucleus;other cell component | other molecular function | 16905 | ENSMUSG00000028063 | Lmna | B3RH23; B3RH24; mmu:16905; P11516; P48678; P97859; Q3TIH0; Q3TTS8; Q3U733; Q3U7I5; Q3UCA0; Q3UCJ8; Q3UCU3; Q91WF2; Q9DC21 | Adipogenesis genes; FAS pathway and stress induction of HSP regulation | 0.236076921565588 | 0.901149690306505 | 4134986.871037207 | 1.1058985470826533E7 | 3.2189609583199937E7 | 6289356.16248022 | 5.369543399964929E7 | 2.2795803719185894 | 0.6050295881452582 | |
| Q02788 | Collagen alpha-2(VI) chain [OS=Mus musculus] | 202.37 | cell adhesion;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component | other molecular function | 12834 | ENSMUSG00000020241 | Col6a2 | mmu:12834; Q02788; Q05505; Q8C972; Q8K229 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | ECM proteoglycans; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; NCAM1 interactions; Collagen chain trimerization; Collagen degradation | 0.156641881403766 | 0.0961283818482991 | 4.136492509189963E7 | 5.21291258166705E7 | 5.586648846604673E7 | 1.173163988850227E7 | 2.0595787144729633E7 | -1.3397404015276635 | -1.8180032772865453 |
| P97927 | Laminin subunit alpha-4 [OS=Mus musculus] | 199.33 | cell adhesion;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | signal transduction activity or receptor binding | 16775 | ENSMUSG00000019846 | Lama4 | mmu:16775; O88785; P70409; P97927; Q14BF2 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Formation of the dystrophin-glycoprotein complex (DGC); Laminin interactions; MET activates PTK2 signaling | 0.329011090732691 | 0.50594120050135 | 5125646.74812024 | 1.037511250312096E7 | 1.8735571837149E7 | 3065544.409694903 | 5760601.1965567535 | -0.8488356911350236 | -0.7415907489564434 |
| P20152 | Vimentin [OS=Mus musculus] | 183.446 | cell organization and biogenesis;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component | cytoskeletal activity;nucleic acid binding activity;other molecular function | 22352 | ENSMUSG00000026728 | Vim | mmu:22352; O08704; P20152; Q8CCH1 | Spinal cord injury; Primary focal segmental glomerulosclerosis (FSGS); Alpha 6 beta 4 integrin signaling pathway | Aggrephagy; Striated Muscle Contraction; Caspase-mediated cleavage of cytoskeletal proteins; RHOBTB1 GTPase cycle | 0.873609880131656 | 0.840672080806375 | 7365249.698992513 | 3.3401280645601466E7 | 8.643236711147267E7 | 1.292797841903164E7 | 7.464184195594883E7 | 1.1600811699488573 | 0.8116903529805907 |
| Q64727 | Vinculin [OS=Mus musculus] | 182.753 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | plasma membrane;other membranes;cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 22330 | ENSMUSG00000021823 | Vcl | mmu:22330; Q64727; Q8BP32; Q8BS46; Q922C5; Q922D9 | Primary focal segmental glomerulosclerosis (FSGS); IL-3 signaling pathway; Regulation of actin cytoskeleton; Integrin-mediated cell adhesion; Focal adhesion | Neutrophil degranulation; High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells; Platelet degranulation ; MAP2K and MAPK activation; Smooth Muscle Contraction; Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells; Regulation of CDH1 Function | 0.964629994744883 | 0.977491813528386 | 1953982.7579073233 | 4840837.086136207 | 1.55412767194393E7 | 2359150.5810886133 | 6758257.200309387 | 0.48139471401466805 | 0.2718497696931775 |
| Q8K4G1 | Latent-transforming growth factor beta-binding protein 4 [OS=Mus musculus] | 180.216 | cell-cell signaling;cell organization and biogenesis;transport;signal transduction | non-structural extracellular;extracellular matrix | other molecular function | 108075 | ENSMUSG00000040488 | Ltbp4 | E9QPD9; mmu:108075; Q8K4G0; Q8K4G1 | TGF-beta receptor signaling activates SMADs; Molecules associated with elastic fibres | 0.775297640004946 | 0.703189639676216 | 1469976.6770863 | 2473680.681365607 | 4126124.1405319436 | 2657641.7444799202 | 7291299.088613093 | 1.5595166020390654 | 0.8543533743061732 | |
| Q68FD5 | Clathrin heavy chain 1 [OS=Mus musculus] | 180.117 | cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes | plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component | nucleic acid binding activity;other molecular function | 67300 | ENSMUSG00000047126 | Cltc | mmu:67300; Q68FD5 | IL-7 signaling pathway; Kit receptor signaling pathway | MHC class II antigen presentation; Recycling pathway of L1; Cargo recognition for clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis; LDL clearance; Retrograde neurotrophin signalling; Formation of annular gap junctions; Lysosome Vesicle Biogenesis; WNT5A-dependent internalization of FZD4; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation; RHOU GTPase cycle; RHOV GTPase cycle | 0.688274955487563 | 0.946476383814868 | 1426606.2225329466 | 2101059.0869428 | 7198111.7488871245 | 2078296.563295177 | 6830362.818457293 | 1.7008454796013681 | 0.5428143634365035 |
| P02469 | Laminin subunit beta-1 [OS=Mus musculus] | 179.863 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;nucleus;other cell component | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 16777 | ENSMUSG00000002900 | Lamb1 | E9PXZ9; P02469 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Inflammatory response pathway; Alpha 6 beta 4 integrin signaling pathway; Focal adhesion | 0.269583968882479 | 0.356773085915651 | 1.4326337702720901E7 | 1.8407714250900764E7 | 2.406357201653607E7 | 2.1078383512013834E7 | 1.149610392953332E7 | -0.6791654838846833 | 0.5570943768396376 | |
| Q01853 | Transitional endoplasmic reticulum ATPase [OS=Mus musculus] | 179.055 | cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;other biological processes | other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component | signal transduction activity or receptor binding;enzyme regulator activity;other molecular function | 269523 | ENSMUSG00000028452 | Vcp | mmu:269523; Q01853; Q3TFH9; Q3TIM2; Q3TXN9; Q6PI18; Q8BSR6; Q8CEG4 | IL-9 signaling pathway | RHOH GTPase cycle; Neutrophil degranulation; Protein methylation; Ovarian tumor domain proteases; Neddylation; ABC-family proteins mediated transport; Translesion Synthesis by POLH; Hedgehog ligand biogenesis; KEAP1-NFE2L2 pathway; HSF1 activation; N-glycan trimming in the ER and Calnexin/Calreticulin cycle; Josephin domain DUBs | 0.953038161729767 | 0.901149690306505 | 5338414.413398174 | 9329554.935730066 | 2.5532499977727503E7 | 4463650.11042755 | 1.2770955118061693E7 | 0.45298626139298054 | -0.2581873602655405 |
| Q03350 | Thrombospondin-2 [OS=Mus musculus] | 178.303 | cell adhesion;other biological processes | non-structural extracellular;extracellular matrix;other cell component | other molecular function | 21826 | ENSMUSG00000023885 | Thbs2 | mmu:21826; Q03350; Q8CG21 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Signaling by PDGF; O-glycosylation of TSR domain-containing proteins | 0.792896707923278 | 0.620448351319483 | 7439397.130180354 | 1.1102887711296873E7 | 1.7857870851453733E7 | 4211942.301314384 | 1.05864549049655E7 | -0.06871539719065865 | -0.820700040470399 |
| Q80YX1 | Tenascin [OS=Mus musculus] | 175.9 | cell adhesion;cell-cell signaling;cell organization and biogenesis;stress response;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | signal transduction activity or receptor binding;other molecular function | 21923 | ENSMUSG00000028364 | Tnc | mmu:21923; Q64706; Q80YX1; Q80YX2 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Focal adhesion | Integrin cell surface interactions; ECM proteoglycans; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 1.08858887903907E-8 | 0.00972980877962454 | 1449614.4281484466 | 1.2106484504902953E7 | 3597849.650032737 | 96243.5238250637 | 211010.04547923067 | -5.842324501720179 | -3.9128359438342706 |
| Q61147 | Ceruloplasmin [OS=Mus musculus] | 175.43 | cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular | other molecular function | 12870 | ENSMUSG00000003617 | Cp | mmu:12870; Q61147; Q6P5C8 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Iron uptake and transport; Metal ion SLC transporters | 0.114472406028442 | 0.217345018530886 | 4703216.257241024 | 9598922.193485493 | 1.8258425380319133E7 | 1756646.5467629798 | 3587720.1567995367 | -1.4198050591681202 | -1.4208237326658222 | |
| Q3UQ28 | Peroxidasin homolog [OS=Mus musculus] | 173.636 | cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes | extracellular matrix;ER/Golgi;other cell component | extracellular structural activity;other molecular function | 69675 | ENSMUSG00000020674 | Pxdn | A4FU83; E9QNQ9; mmu:69675; Q3UQ28 | Crosslinking of collagen fibrils | 0.414844709855988 | 0.622521206052951 | 3468268.863888983 | 1.0141728842991263E7 | 7424302.20024892 | 1748064.7562207088 | 5865453.59009746 | -0.789989022164196 | -0.988457112373562 | |
| Q61316 | Heat shock 70 kDa protein 4 [OS=Mus musculus] | 169.044 | protein metabolism;other metabolic processes | other cell component | other molecular function | Hspa4 | Q61316 | Regulation of HSF1-mediated heat shock response | 0.937908804051419 | 0.905946265571965 | 1715523.4149199834 | 3885769.0116153997 | 1.2475039717842167E7 | 1450318.0074060035 | 4790126.20554149 | 0.3018635242804291 | -0.2422795462920771 | |||
| Cont_P02533 | Keratin, type I cytoskeletal 14 OS=Homo sapiens OX=9606 GN=KRT14 PE=1 SV=4 | 164.831 | cell organization and biogenesis;other biological processes | plasma membrane;cytosol;cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 3861 | ENSG00000186847 | KRT14 | hsa:3861; P02533; Q14715; Q53XY3; Q9BUE3; Q9UBN2; Q9UBN3; Q9UCY4 | Corticotropin-releasing hormone signaling | Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin; Developmental Lineage of Mammary Gland Myoepithelial Cells; Type I hemidesmosome assembly | 0.735573385767802 | 0.645534074006669 | 1.0299655985485494E7 | 9892865.41378706 | 7326107.9926405 | 2.9333304518974166E7 | 9460012.597296894 | -0.06454634544610054 | 1.5099434544998684 |
| P11499 | Heat shock protein HSP 90-beta [OS=Mus musculus] | 164.719 | cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component | enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function | 15516 | ENSMUSG00000023944 | Hsp90ab1 | mmu:15516; O89078; P11499; Q3UIQ7 | Focal adhesion: PI3K-Akt-mTOR signaling pathway | Neutrophil degranulation; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of actin dynamics for phagocytic cup formation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Attenuation phase; Estrogen-dependent gene expression; Sema3A PAK dependent Axon repulsion; Aryl hydrocarbon receptor signalling; DDX58/IFIH1-mediated induction of interferon-alpha/beta; HSF1 activation; RHOBTB2 GTPase cycle; The NLRP3 inflammasome | 0.952333191127893 | 0.975071223710592 | 1.0807613687705928E7 | 3.193268303009924E7 | 8.29576662608192E7 | 1.1608041082716169E7 | 4.22825068683512E7 | 0.4050271392280359 | 0.10307651810960865 |
| Q9JKF1 | Ras GTPase-activating-like protein IQGAP1 [OS=Mus musculus] | 163.926 | cell organization and biogenesis;developmental processes;signal transduction;other biological processes | plasma membrane;other membranes;cytoskeleton;nucleus;other cell component | enzyme regulator activity;other molecular function | 29875 | ENSMUSG00000030536 | Iqgap1 | G3UW45; mmu:29875; Q9JKF1 | G13 signaling pathway; Regulation of actin cytoskeleton | RHO GTPases activate IQGAPs; Neutrophil degranulation; RAC1 GTPase cycle; RAC2 GTPase cycle; RHOA GTPase cycle; MAP2K and MAPK activation; RHOQ GTPase cycle; RHOC GTPase cycle; RHOU GTPase cycle; RHOV GTPase cycle; Nephrin family interactions | 0.830676695521175 | 0.777195460870953 | 331165.4406654323 | 1068898.0084058929 | 3041433.200354057 | 944145.2185002686 | 3795509.9873349466 | 1.8281695465197003 | 1.5114566510612586 |
| P52480 | Pyruvate kinase PKM [OS=Mus musculus] | 163.393 | cell organization and biogenesis;other metabolic processes;other biological processes | cytosol;ER/Golgi;nucleus;other cell component | nucleic acid binding activity;kinase activity;other molecular function | 18746 | ENSMUSG00000032294 | Pkm | mmu:18746; P52480; Q3TBV8; Q3TBW5; Q3TC59; Q3U1X3; Q3U5P6; Q4VC20; Q64484; Q91YI8; Q9CWB1 | Glycolysis and gluconeogenesis; Purine metabolism | Neutrophil degranulation; Pyruvate metabolism; Glycolysis; Regulation of pyruvate metabolism | 0.938859506774495 | 0.958705855138011 | 1.1706302394897154E7 | 1.6687028973496003E7 | 3.53200761892009E7 | 1.3595916090065738E7 | 3.1698865102110166E7 | 0.9257040749614063 | 0.215887911460558 |
| P63017 | Heat shock cognate 71 kDa protein [OS=Mus musculus] | 161.557 | cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component | signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function | 15481 | ENSMUSG00000015656 | Hspa8 | mmu:15481; P08109; P12225; P63017; Q3U6R0; Q3U764; Q3U7D7; Q3U7E2; Q3U9B4; Q3U9G0; Q3UGM0; Q5FWJ6; Q62373; Q62374; Q62375; Q6NZD0 | Mapk signaling pathway; Exercise-induced circadian regulation | Neutrophil degranulation; mRNA Splicing - Major Pathway; Regulation of HSF1-mediated heat shock response; PKR-mediated signaling; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis; Attenuation phase; Lysosome Vesicle Biogenesis; GABA synthesis, release, reuptake and degradation; AUF1 (hnRNP D0) binds and destabilizes mRNA; Protein methylation | 0.987939278265184 | 0.709593139419252 | 1.5723480869725833E7 | 2.2348098618015703E7 | 7.359719450565854E7 | 1.2001189016638666E7 | 3.440867978172333E7 | 0.6226204469568586 | -0.38974328950384013 |
| Q9JHU4 | Cytoplasmic dynein 1 heavy chain 1 [OS=Mus musculus] | 161.009 | cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes | cytoskeleton;other cell component | cytoskeletal activity;other molecular function | 13424 | ENSMUSG00000018707 | Dync1h1 | E9QM71; mmu:13424; Q9JHU4 | MHC class II antigen presentation; Neutrophil degranulation; Separation of Sister Chromatids; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; COPI-mediated anterograde transport; Recruitment of NuMA to mitotic centrosomes; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-independent Golgi-to-ER retrograde traffic; Aggrephagy; Anchoring of the basal body to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; AURKA Activation by TPX2 | 0.771389136401717 | 0.695927216301667 | 451351.8596347517 | 1275535.4534856554 | 3370818.0273642703 | 1462326.6297541 | 5162177.518126 | 2.0168767548265785 | 1.695941135437884 | |
| Q99K41 | EMILIN-1 [OS=Mus musculus] | 157.011 | cell adhesion;cell organization and biogenesis;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component | signal transduction activity or receptor binding;extracellular structural activity;other molecular function | 100952 | ENSMUSG00000029163 | Emilin1 | mmu:100952; Q99K41 | Molecules associated with elastic fibres | 0.169879542413978 | 0.0921665663508908 | 1671715.86234765 | 5498413.09956387 | 5014687.354848887 | 384416.66366236034 | 2364922.89508055 | -1.2172221542664499 | -2.120586876331411 | |
| Q61879 | Myosin-10 [OS=Mus musculus] | 146 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | cytoskeletal activity;nucleic acid binding activity;other molecular function | 77579 | ENSMUSG00000020900 | Myh10 | mmu:77579; Q5SV63; Q61879 | Regulation of actin cytoskeleton | RHO GTPases activate PAKs | 0.996007724449986 | 0.953146340313072 | 266023.60455562966 | 458865.269073755 | 1364536.1643212799 | 562909.3462758837 | 1089526.38375758 | 1.2475586126477243 | 1.0813483389566705 |
| Cont_P00761 | Trypsin OS=Sus scrofa OX=9823 PE=1 SV=1 | 143.502 | protein metabolism;other biological processes | non-structural extracellular | other molecular function | 0.822223648478518 | 0.960577895552113 | 3.334729419178533E9 | 2.1792138371661735E9 | 1.3557622678922963E9 | 4.479417756781787E9 | 2.35988129070601E9 | 0.11490652036236093 | 0.42574151472675936 | ||||||
| P20029 | Endoplasmic reticulum chaperone BiP [OS=Mus musculus] | 142.966 | protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component | enzyme regulator activity;translation activity;other molecular function | 14828 | ENSMUSG00000026864 | Hspa5 | mmu:14828; O35642; P20029; Q3UFF2; Q61630 | Mapk signaling pathway | Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Regulation of HSF1-mediated heat shock response | 0.916283277860523 | 0.985707795620743 | 7392689.481756757 | 8222965.927916382 | 1.797212351620547E7 | 8403011.594768586 | 1.57890948929286E7 | 0.9411977151669085 | 0.1848071583319896 |
| Cont_P13647 | Keratin, type II cytoskeletal 5 OS=Homo sapiens OX=9606 GN=KRT5 PE=1 SV=3 | 142.395 | cell organization and biogenesis;other biological processes | cytosol;cytoskeleton;other cell component | bone, tooth or skin structural activity;cytoskeletal activity;other molecular function | 3852 | ENSG00000186081 | KRT5 | hsa:3852; P13647; Q6PI71; Q6UBJ0; Q8TA91 | Formation of the cornified envelope; Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin; Developmental Lineage of Mammary Stem Cells; Developmental Lineage of Mammary Gland Myoepithelial Cells; Type I hemidesmosome assembly | 0.873755746039336 | 0.2733017775894 | 7868513.182470503 | 9974982.226041706 | 1.0805570452735417E7 | 2.8752414910160065E7 | 1.3998817771053001E7 | 0.4889188179733309 | 1.8695201748341668 | |
| Cont_P08779 | Keratin, type I cytoskeletal 16 OS=Homo sapiens OX=9606 GN=KRT16 PE=1 SV=4 | 140.751 | cell organization and biogenesis;stress response;other biological processes | plasma membrane;cytosol;cytoskeleton | cytoskeletal activity | 3868 | ENSG00000186832 | KRT16 | A8K488; hsa:3868; P08779; P30654; Q16402; Q9UBG8 | Vitamin D receptor pathway | Formation of the cornified envelope | 0.82543231800733 | 0.895302208460818 | 3908256.3409277797 | 2249474.51763106 | 2096552.2825116366 | 5401589.786976026 | 2569640.8216647534 | 0.19197869304636359 | 0.46685898520849145 |
| Cont_P02465 | Collagen alpha-2(I) chain OS=Bos taurus OX=9913 GN=COL1A2 PE=1 SV=2 | 139.99 | non-structural extracellular;extracellular matrix | extracellular structural activity;other molecular function | 282188 | ENSBTAG00000013472 | COL1A2 | A6QP13; bta:282188; O62649; P02465 | Inflammatory response pathway; Focal adhesion | Fibronectin matrix formation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Collagen degradation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; Collagen chain trimerization; GPVI-mediated activation cascade; Platelet Aggregation (Plug Formation); Platelet Adhesion to exposed collagen; GP1b-IX-V activation signalling | 0.731850662833984 | 0.549852418071669 | 85775.39066064726 | 163731.944383145 | 196860.296999494 | 48702.045776696206 | 54970.44581499727 | -1.57460773663475 | -0.8165814161100421 | |
| Cont_P12763 | Alpha-2-HS-glycoprotein OS=Bos taurus OX=9913 GN=AHSG PE=1 SV=2 | 132.772 | stress response;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component | enzyme regulator activity | 280988 | AHSG | A6QLF7; bta:280988; P12763 | Neutrophil degranulation; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 0.946568086066385 | 0.335956814949331 | 8.712402787486216E8 | 6.41500953397899E8 | 4.2252677685996836E8 | 4.440672611032756E8 | 7.064361313920757E8 | 0.13910772352571524 | -0.9722924411478902 | ||
| P07901 | Heat shock protein HSP 90-alpha [OS=Mus musculus] | 132.382 | cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component | signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function | 15519 | ENSMUSG00000021270 | Hsp90aa1 | mmu:15519; P07901 | EBV LMP1 signaling; Focal adhesion: PI3K-Akt-mTOR signaling pathway; IL-6 signaling pathway; IL-2 signaling pathway | Regulation of necroptotic cell death; Recruitment of NuMA to mitotic centrosomes; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of actin dynamics for phagocytic cup formation; Neutrophil degranulation; Downregulation of ERBB2 signaling; Anchoring of the basal body to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; AURKA Activation by TPX2; Extra-nuclear estrogen signaling; Attenuation phase; Estrogen-dependent gene expression; Sema3A PAK dependent Axon repulsion; VEGFR2 mediated vascular permeability; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation; DDX58/IFIH1-mediated induction of interferon-alpha/beta; eNOS activation; HSF1 activation; RHOBTB2 GTPase cycle; Drug-mediated inhibition of ERBB2 signaling | 0.974827674952665 | 0.968364585136618 | 1667357.9717776468 | 3968795.71909318 | 1.1896107480962433E7 | 1606774.576019598 | 6014683.841021903 | 0.5997875986262169 | -0.0533963366441969 |
| Q02819 | Nucleobindin-1 [OS=Mus musculus] | 131.152 | signal transduction | non-structural extracellular;other membranes;ER/Golgi | enzyme regulator activity;nucleic acid binding activity;other molecular function | 18220 | ENSMUSG00000030824 | Nucb1 | mmu:18220; Q02819; Q3TU42; Q9CWA1; Q9D8J4; Q9DBL3 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation | 0.0679830640731695 | 0.397987186613988 | 5493436.34719679 | 1.9240052036173E7 | 2.4992726743775133E7 | 2379424.5332984333 | 6548209.148806977 | -1.5549403938694841 | -1.2070961924278651 | |
| Q91V92 | ATP-citrate synthase [OS=Mus musculus] | 129.973 | other metabolic processes | cytosol | other molecular function | 104112 | ENSMUSG00000020917 | Acly | mmu:104112; Q91V92 | Fatty acid biosynthesis | Neutrophil degranulation; Fatty acyl-CoA biosynthesis | 0.626059420687734 | 0.643183834410259 | 1276919.6113413726 | 2339759.4103227933 | 7993361.0560920695 | 644183.8162072281 | 1777761.9344937534 | -0.39629804848056854 | -0.9871233812801825 |
| A2ASQ1 | Agrin [OS=Mus musculus] | 128.989 | cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes | non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cell component | signal transduction activity or receptor binding;other molecular function | 11603 | ENSMUSG00000041936 | Agrn | A2ASP9; A2ASQ0; A2ASQ1; B2RWU1 | Primary focal segmental glomerulosclerosis (FSGS) | ECM proteoglycans; Retinoid metabolism and transport; Glycosaminoglycan-protein linkage region biosynthesis; HS-GAG biosynthesis; HS-GAG degradation; Formation of the dystrophin-glycoprotein complex (DGC) | 0.460727828548759 | 0.686318824668434 | 1695001.2322350666 | 3018900.06344302 | 4324221.40670855 | 1028829.4241236168 | 2045725.4701757336 | -0.561410446190177 | -0.72028251328634 |
| Q61508 | Extracellular matrix protein 1 [OS=Mus musculus] | 127.379 | stress response;developmental processes;signal transduction;other biological processes | non-structural extracellular | signal transduction activity or receptor binding;other molecular function | 13601 | ENSMUSG00000028108 | Ecm1 | mmu:13601; Q3U5Q5; Q61508 | Platelet degranulation | 2.27890527565265E-4 | 1.51989274634622E-7 | 5.132626536679041E7 | 6.196550035866306E7 | 5.7086940781247534E7 | 3515293.344106073 | 1.1331897286900917E7 | -2.4510757802272813 | -3.8679803006942106 | |
| Cont_P04259 | Keratin, type II cytoskeletal 6B OS=Homo sapiens OX=9606 GN=KRT6B PE=1 SV=5 | 126.901 | cell organization and biogenesis;other biological processes | cytosol;cytoskeleton | bone, tooth or skin structural activity;cytoskeletal activity | 3854 | ENSG00000185479 | KRT6B | hsa:3854; P04259; P48669 | Formation of the cornified envelope | 0.854305439376382 | 0.937453377971347 | 1156058.5455969477 | 510017.07482617133 | 452820.542152991 | 1115770.6869766254 | 854901.7358096777 | 0.7452130553684702 | -0.05117390608584228 | |
| P17182 | Alpha-enolase [OS=Mus musculus] | 126.804 | other metabolic processes;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;other cell component | nucleic acid binding activity;other molecular function | 13806; 433182 | ENSMUSG00000059040; ENSMUSG00000063524 | Eno1 | mmu:13806; mmu:433182; P17182; Q99KT7; Q9DCY7 | Glycolysis and gluconeogenesis | 0.720832939248489 | 0.858218537342417 | 9473047.660860082 | 1.1146559483992001E7 | 2.0899983974591535E7 | 1.3905788568310633E7 | 2.89416009584274E7 | 1.3765462552828784 | 0.5537850111265004 | |
| P08113 | Endoplasmin [OS=Mus musculus] | 126.346 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cell component | signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function | 22027 | ENSMUSG00000020048 | Hsp90b1 | mmu:22027; P08113; P11427 | Focal adhesion: PI3K-Akt-mTOR signaling pathway; Hypoxia-dependent self-renewal of myoblasts | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Scavenging by Class A Receptors; Trafficking and processing of endosomal TLR; Interleukin-4 and Interleukin-13 signaling | 0.854305439376382 | 0.866766165039268 | 4030450.84914005 | 5006439.15200075 | 1.2828763316623202E7 | 6037105.20140975 | 1.2434595462188734E7 | 1.3125028215609296 | 0.5829157128019473 |
| P58252 | Elongation factor 2 [OS=Mus musculus] | 126.048 | cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes | plasma membrane;other membranes;cytosol;translational apparatus;other cell component | cytoskeletal activity;translation activity;nucleic acid binding activity;other molecular function | 13629 | ENSMUSG00000034994 | Eef2 | mmu:13629; P58252; Q544E4 | Translation factors | Neutrophil degranulation; Protein methylation; Peptide chain elongation; Synthesis of diphthamide-EEF2 | 0.922179983282929 | 0.866546043492515 | 6414138.274151959 | 1.0566307796994643E7 | 2.9620591728864197E7 | 4859646.5618234025 | 1.3065706600835832E7 | 0.3063138071523588 | -0.4004040637211755 |
| Cont_P02538 | Keratin, type II cytoskeletal 6A OS=Homo sapiens OX=9606 GN=KRT6A PE=1 SV=3 | 123.757 | cell organization and biogenesis;stress response;other biological processes | cytosol;cytoskeleton | bone, tooth or skin structural activity;cytoskeletal activity | 3853 | ENSG00000205420 | KRT6A | A4QPC1; hsa:3853; P02538; P48667; Q08AR4; Q6NT67; Q96CL4 | Ectoderm differentiation; Ectoderm differentiation; Pancreatic cancer subtypes | Formation of the cornified envelope | 0.792564971776066 | 0.709593139419252 | 4785085.111074816 | 3779160.7730984767 | 3044210.664784646 | 8485501.699692694 | 3982846.61307857 | 0.07573402481836149 | 0.826455374898488 |
| P97298 | Pigment epithelium-derived factor [OS=Mus musculus] | 123.502 | cell cycle OR cell proliferation;developmental processes;other biological processes | non-structural extracellular;extracellular matrix;other cell component | enzyme regulator activity | 20317 | ENSMUSG00000000753 | Serpinf1 | mmu:20317; O70629; O88691; P97298 | 0.00901230529014985 | 0.300753028734261 | 1.46490289953418E7 | 7.121805491857927E7 | 6.883649650666605E7 | 5921015.69252881 | 1.5757205380580032E7 | -2.1762313456020066 | -1.3068884569216235 | ||
| Q70E20 | Sushi, nidogen and EGF-like domain-containing protein 1 [OS=Mus musculus] | 122.942 | cell adhesion | non-structural extracellular;extracellular matrix | other molecular function | 208777 | Sned1 | A6H6I3; mmu:208777; Q70E20; Q810H2; Q8BMD9 | 0.889058672589993 | 0.817293288705596 | 3293936.3484006864 | 6267209.5561869135 | 8981713.661313256 | 4995161.517920501 | 1.4223395042125002E7 | 1.1823707306994269 | 0.6007186512533814 | |||
| P13020 | Gelsolin [OS=Mus musculus] | 122.934 | cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component | cytoskeletal activity;other molecular function | 227753 | ENSMUSG00000026879 | Gsn | mmu:227753; P13020; Q3UPB1; Q8R590 | Regulation of actin cytoskeleton | Neutrophil degranulation; Caspase-mediated cleavage of cytoskeletal proteins | 0.65414435708462 | 0.709593139419252 | 6438031.44422588 | 9825643.045518672 | 2.1865108079878632E7 | 1.1033925013460701E7 | 2.9144067496602204E7 | 1.5685785077495134 | 0.7772545527981521 |
| Q61398 | Procollagen C-endopeptidase enhancer 1 [OS=Mus musculus] | 120.4 | protein metabolism;other biological processes | enzyme regulator activity;other molecular function | 18542 | ENSMUSG00000029718 | Pcolce | mmu:18542; O35113; Q61398 | mRNA processing | Collagen biosynthesis and modifying enzymes; Crosslinking of collagen fibrils | 0.133905327763598 | 0.0895861566882082 | 2.52047208020085E7 | 2.958750643636163E7 | 3.717663177971887E7 | 7672570.19904635 | 1.2538308810459368E7 | -1.2386453468264698 | -1.7159121278098002 | |
| P26039 | Talin-1 [OS=Mus musculus] | 118.226 | cell adhesion;cell organization and biogenesis;signal transduction | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;other molecular function | 21894 | ENSMUSG00000028465 | Tln1 | A2AIM8; mmu:21894; P26039; Q8VEF0 | Primary focal segmental glomerulosclerosis (FSGS); Integrin-mediated cell adhesion; Focal adhesion | Platelet degranulation ; MAP2K and MAPK activation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; Smooth Muscle Contraction; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 0.850917681937748 | 0.87222702623065 | 165904.24421521465 | 567933.664164035 | 2047443.5453512298 | 286851.2614141297 | 2291518.0404973766 | 2.0125093088074704 | 0.7899520679334946 |
| Q8BPB5 | EGF-containing fibulin-like extracellular matrix protein 1 [OS=Mus musculus] | 117.738 | protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes | extracellular matrix | signal transduction activity or receptor binding;kinase activity;other molecular function | 216616 | ENSMUSG00000020467 | Efemp1 | mmu:216616; Q6Y3N6; Q8BPB5 | 0.278244203695445 | 0.145805028390539 | 4441372.613318663 | 7007290.288389671 | 9374363.446007233 | 1370373.3251651835 | 3606517.1409647237 | -0.9582503828225413 | -1.6964366384968077 | ||
| P09411 | Phosphoglycerate kinase 1 [OS=Mus musculus] | 116.462 | protein metabolism;other metabolic processes;stress response;other biological processes | non-structural extracellular;other membranes;cytosol;mitochondrion;other cell component | kinase activity;other molecular function | 18655 | ENSMUSG00000062070 | Pgk1 | mmu:18655; P09411; Q3TPE6; Q3UKV8; Q5XJE7 | Glycolysis and gluconeogenesis | Gluconeogenesis; Glycolysis | 0.465126095372736 | 0.820281310709571 | 3210948.6178334034 | 3594147.655304653 | 7046094.17133664 | 4500077.619792943 | 1.4795712145397767E7 | 2.041457553634679 | 0.48695030706009684 |
| P27773 | Protein disulfide-isomerase A3 [OS=Mus musculus] | 115.891 | cell adhesion;cell organization and biogenesis;stress response;signal transduction;other biological processes | non-structural extracellular;other membranes;ER/Golgi;other cell component | nucleic acid binding activity;other molecular function | 14827 | ENSMUSG00000027248 | Pdia3 | mmu:14827; P27773; Q3TEI9; Q3TIL2; Q3UZK8; Q8C2F4; Q99LF6 | ER-Phagosome pathway; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Calnexin/calreticulin cycle | 0.850917681937748 | 0.881496352314601 | 5161827.016313557 | 6480316.532156386 | 1.845644105269933E7 | 7238345.98431998 | 1.5315044241817234E7 | 1.2408133459469528 | 0.48777827396885565 | |
| P10107 | Annexin A1 [OS=Mus musculus] | 115.566 | cell organization and biogenesis;stress response;transport;signal transduction;other biological processes | non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component | enzyme regulator activity;other molecular function | 16952 | ENSMUSG00000024659 | Anxa1 | mmu:16952; P10107 | Spinal cord injury; Prostaglandin synthesis and regulation | G alpha (q) signalling events; G alpha (i) signalling events; Formyl peptide receptors bind formyl peptides and many other ligands | 0.954328834404239 | 0.529099828181544 | 1675870.316312303 | 6017153.19339518 | 1.1246783571413433E7 | 4211649.667813237 | 1.08370832078509E7 | 0.8488235161720351 | 1.3294749220803617 |
| Cont_Q2KJF1 | Alpha-1B-glycoprotein OS=Bos taurus OX=9913 GN=A1BG PE=1 SV=1 | 115.502 | signal transduction | non-structural extracellular;plasma membrane;other membranes | 518955 | A1BG | bta:518955; Q2KJF1 | Platelet degranulation ; Neutrophil degranulation | 0.932231143665149 | 0.601376052147163 | 9820849.23751892 | 8859077.038578315 | 5863583.3120338395 | 6762503.63408608 | 1.0317459698123023E7 | 0.21985949488281362 | -0.5382903197621131 | |||
| Cont_Q3MHN5 | Vitamin D-binding protein OS=Bos taurus OX=9913 GN=GC PE=2 SV=1 | 113.599 | other metabolic processes;transport | non-structural extracellular;other cell component | transporter activity;cytoskeletal activity;other molecular function | 530076 | GC | bta:530076; Q3MHN5 | 0.946173787415917 | 0.570795727084329 | 1.5974245944817802E7 | 1.026921939097026E7 | 8132938.425379939 | 1.0785165311962552E7 | 1.4618596373270534E7 | 0.5094782752262966 | -0.5666995412925446 | |||
| P17742 | Peptidyl-prolyl cis-trans isomerase A [OS=Mus musculus] | 113.527 | cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes | non-structural extracellular;cytosol;nucleus;other cell component | signal transduction activity or receptor binding;other molecular function | 268373 | ENSMUSG00000071866 | Ppia | mmu:268373; P17742; Q9CWJ5; Q9R137 | Neutrophil degranulation; Basigin interactions | 0.946239447314336 | 0.937453377971347 | 1.0145464905716315E7 | 3.610988970082183E7 | 6.97111893668837E7 | 1.0696784170781441E7 | 4.607074026803666E7 | 0.3514567659376412 | 0.07634216032534753 | |
| Q69ZN7 | Myoferlin [OS=Mus musculus] | 112.647 | cell organization and biogenesis;other metabolic processes;stress response;other biological processes | plasma membrane;other membranes;nucleus | other molecular function | 226101 | ENSMUSG00000048612 | Myof | mmu:226101; Q69ZN7; Q7TMG0; Q80V33; Q8BU64; Q8BU70; Q8BUC1; Q8BVY6; Q8C0D1; Q8R3B4 | 0.816275429153737 | 0.609903091678244 | 322363.41862436634 | 911704.7850761963 | 2642353.10757036 | 1104935.9693987637 | 3065805.015040973 | 1.7496272919339693 | 1.7772028252973333 | ||
| P26041 | Moesin [OS=Mus musculus] | 112.068 | cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function | 17698 | ENSMUSG00000031207 | Msn | B1AX70; mmu:17698; P26041; Q3UL28; Q8BSN4 | Regulation of actin cytoskeleton | Recycling pathway of L1 | 0.910750689050232 | 0.97925982662951 | 9136364.2843242 | 1.7052591672350097E7 | 3.507274229077233E7 | 1.120013397828275E7 | 1.9030746620886367E7 | 0.15834114468472432 | 0.29382391022615884 |
| P05064 | Fructose-bisphosphate aldolase A [OS=Mus musculus] | 112.015 | cell organization and biogenesis;other metabolic processes;other biological processes | plasma membrane;other membranes;cytosol;cytoskeleton;other cell component | other molecular function | 11674 | ENSMUSG00000030695 | Aldoa | mmu:11674; P05064 | Glycolysis and gluconeogenesis | Platelet degranulation ; Neutrophil degranulation; Gluconeogenesis; Glycolysis | 0.907383519445145 | 0.988377544628277 | 4319055.57861477 | 4893427.94836492 | 1.3571821307477335E7 | 4518789.603964283 | 1.0653934694757948E7 | 1.1224689803597754 | 0.0652205047103212 |
| B2RQC6 | Multifunctional protein CAD [OS=Mus musculus] | 111.853 | other metabolic processes;stress response;transport;developmental processes;other biological processes | cytosol;nucleus;other cell component | kinase activity;other molecular function | 69719 | ENSMUSG00000013629 | Cad | B2RQC6; B7ZN27; mmu:69719 | Mechanisms associated with pluripotency | Pyrimidine biosynthesis | 0.340675523776301 | 0.798180783050573 | 448793.6641228067 | 957747.5456383955 | 3728337.7638301034 | 139659.55402474166 | 452794.3373622177 | -1.0807895075821645 | -1.6841380378584145 |
| Q8BND5 | Sulfhydryl oxidase 1 [OS=Mus musculus] | 111.186 | cell organization and biogenesis;other biological processes | non-structural extracellular;other membranes;ER/Golgi | other molecular function | 104009 | ENSMUSG00000033684 | Qsox1 | mmu:104009; Q3TDY9; Q3TE19; Q3TR29; Q3UEL4; Q8BND5; Q8K041; Q9DBL6 | Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Neutrophil degranulation | 0.203109767081086 | 0.331332346840573 | 3849451.1157268733 | 1.052758137572049E7 | 1.39599253643295E7 | 1818282.5759143168 | 5040172.36278756 | -1.0626290505699043 | -1.082076326435299 |
