Tick Ascending Limb cell_Parametric ODE Equations

Selected Cell

Cell:

Value:

Sheet1

100

101

102

103

104

105

106

107

108

109

110

111

112

113

114

115

116

117

118

119

120

121

122

123

124

125

126

127

128

129

130

131

132

133

134

135

136

137

138

139

140

141

142

143

144

145

146

147

148

149

150

151

152

153

154

155

156

157

158

159

160

161

162

163

164

165

166

167

168

169

170

171

172

173

174

175

176

177

178

179

180

181

182

183

184

185

186

187

188

189

190

191

192

193

194

195

196

197

198

199

200

Reaction ID	Reactants	Products	Original Text	ODE Equations
R1	SP1_p + STAT3_p	SIGNOR-C74	SP1_p + STAT3_p → SIGNOR-C74	V(1) = K(1,1) * [STAT3_p] * [SP1_p] -K(1,2) * [SIGNOR-C74];
R2	STAT1_p + STAT3_p	SIGNOR-C118	STAT1_p + STAT3_p → SIGNOR-C118	V(2) = K(2,1) * [STAT1_p] * [STAT3_p] -K(2,2) * [SIGNOR-C118];
R3	JAK1_p + SIGNOR-C118_p	SIGNOR-C120	JAK1_p + SIGNOR-C118_p → SIGNOR-C120	V(3) = K(3,1) * [SIGNOR-C118_p] * [JAK1_p] -K(3,2) * [SIGNOR-C120];
R4	SMAD2 + TGFBR1	TGFBR1 \|SMAD2	SMAD2 + TGFBR1 → TGFBR1 \|SMAD2	V(4) = K(4,1) * [TGFBR1] * [SMAD2] -K(4,2) * [TGFBR1 \|SMAD2];
R5	TGFBR1 \|SMAD2	SMAD2_p + TGFBR1	TGFBR1 \|SMAD2 → SMAD2_p + TGFBR1	V(5) = K(5,1) * [TGFBR1 \|SMAD2];
R6	AKT1_p + FOXO1	AKT1_p \|FOXO1	AKT1_p + FOXO1 → AKT1_p \|FOXO1	V(6) = K(6,1) * [AKT1_p] * [FOXO1] -K(6,2) * [AKT1_p \|FOXO1];
R7	AKT1_p \|FOXO1	AKT1_p + FOXO1_p	AKT1_p \|FOXO1 → AKT1_p + FOXO1_p	V(7) = K(7,1) * [AKT1_p \|FOXO1];
R8	JAK2_p + STAT5A	JAK2_p \|STAT5A	JAK2_p + STAT5A → JAK2_p \|STAT5A	V(8) = K(8,1) * [JAK2_p] * [STAT5A] -K(8,2) * [JAK2_p \|STAT5A];
R9	JAK2_p \|STAT5A	JAK2_p + STAT5A_p	JAK2_p \|STAT5A → JAK2_p + STAT5A_p	V(9) = K(9,1) * [JAK2_p \|STAT5A];
R10	IKBKB + IKBKB_p	IKBKB_p \|IKBKB	IKBKB + IKBKB_p → IKBKB_p \|IKBKB	V(10) = K(10,1) * [IKBKB_p] * [IKBKB] -K(10,2) * [IKBKB_p \|IKBKB];
R11	IKBKB_p \|IKBKB	IKBKB_p + IKBKB_p	IKBKB_p \|IKBKB → IKBKB_p + IKBKB_p	V(11) = K(11,1) * [IKBKB_p \|IKBKB];
R12	JAK2 + JAK2_p	JAK2_p \|JAK2	JAK2 + JAK2_p → JAK2_p \|JAK2	V(12) = K(12,1) * [JAK2_p] * [JAK2] -K(12,2) * [JAK2_p \|JAK2];
R13	JAK2_p \|JAK2	JAK2_p + JAK2_p	JAK2_p \|JAK2 → JAK2_p + JAK2_p	V(13) = K(13,1) * [JAK2_p \|JAK2];
R14	AKT1_p + EZH2	AKT1_p \|EZH2	AKT1_p + EZH2 → AKT1_p \|EZH2	V(14) = K(14,1) * [AKT1_p] * [EZH2] -K(14,2) * [AKT1_p \|EZH2];
R15	AKT1_p \|EZH2	AKT1_p + EZH2_p	AKT1_p \|EZH2 → AKT1_p + EZH2_p	V(15) = K(15,1) * [AKT1_p \|EZH2];
R16	IKBKB + PDPK1_p	PDPK1_p \|IKBKB	IKBKB + PDPK1_p → PDPK1_p \|IKBKB	V(16) = K(16,1) * [PDPK1_p] * [IKBKB] -K(16,2) * [PDPK1_p \|IKBKB];
R17	PDPK1_p \|IKBKB	IKBKB_p + PDPK1_p	PDPK1_p \|IKBKB → IKBKB_p + PDPK1_p	V(17) = K(17,1) * [PDPK1_p \|IKBKB];
R18	AKT1_p + NR4A1	AKT1_p \|NR4A1	AKT1_p + NR4A1 → AKT1_p \|NR4A1	V(18) = K(18,1) * [AKT1_p] * [NR4A1] -K(18,2) * [AKT1_p \|NR4A1];
R19	AKT1_p \|NR4A1	AKT1_p + NR4A1_p	AKT1_p \|NR4A1 → AKT1_p + NR4A1_p	V(19) = K(19,1) * [AKT1_p \|NR4A1];
R20	FYN_p + PTPN6	FYN_p \|PTPN6	FYN_p + PTPN6 → FYN_p \|PTPN6	V(20) = K(20,1) * [FYN_p] * [PTPN6] -K(20,2) * [FYN_p \|PTPN6];
R21	FYN_p \|PTPN6	FYN_p + PTPN6_p	FYN_p \|PTPN6 → FYN_p + PTPN6_p	V(21) = K(21,1) * [FYN_p \|PTPN6];
R22	INSR + INSR_p	INSR_p \|INSR	INSR + INSR_p → INSR_p \|INSR	V(22) = K(22,1) * [INSR_p] * [INSR] -K(22,2) * [INSR_p \|INSR];
R23	INSR_p \|INSR	INSR_p + INSR_p	INSR_p \|INSR → INSR_p + INSR_p	V(23) = K(23,1) * [INSR_p \|INSR];
R24	JAK1_p + STAT1	JAK1_p \|STAT1	JAK1_p + STAT1 → JAK1_p \|STAT1	V(24) = K(24,1) * [JAK1_p] * [STAT1] -K(24,2) * [JAK1_p \|STAT1];
R25	JAK1_p \|STAT1	JAK1_p + STAT1_p	JAK1_p \|STAT1 → JAK1_p + STAT1_p	V(25) = K(25,1) * [JAK1_p \|STAT1];
R26	AKT1_p + HSPB1	AKT1_p \|HSPB1	AKT1_p + HSPB1 → AKT1_p \|HSPB1	V(26) = K(26,1) * [AKT1_p] * [HSPB1] -K(26,2) * [AKT1_p \|HSPB1];
R27	AKT1_p \|HSPB1	AKT1_p + HSPB1_p	AKT1_p \|HSPB1 → AKT1_p + HSPB1_p	V(27) = K(27,1) * [AKT1_p \|HSPB1];
R28	PKN1 + PKN1_p	PKN1_p \|PKN1	PKN1 + PKN1_p → PKN1_p \|PKN1	V(28) = K(28,1) * [PKN1_p] * [PKN1] -K(28,2) * [PKN1_p \|PKN1];
R29	PKN1_p \|PKN1	PKN1_p + PKN1_p	PKN1_p \|PKN1 → PKN1_p + PKN1_p	V(29) = K(29,1) * [PKN1_p \|PKN1];
R30	AKT1_p + CDKN1A	AKT1_p \|CDKN1A	AKT1_p + CDKN1A → AKT1_p \|CDKN1A	V(30) = K(30,1) * [AKT1_p] * [CDKN1A] -K(30,2) * [AKT1_p \|CDKN1A];
R31	AKT1_p \|CDKN1A	AKT1_p + CDKN1A_p	AKT1_p \|CDKN1A → AKT1_p + CDKN1A_p	V(31) = K(31,1) * [AKT1_p \|CDKN1A];
R32	CDKN2A + IKBKB_p	IKBKB_p \|CDKN2A	CDKN2A + IKBKB_p → IKBKB_p \|CDKN2A	V(32) = K(32,1) * [IKBKB_p] * [CDKN2A] -K(32,2) * [IKBKB_p \|CDKN2A];
R33	IKBKB_p \|CDKN2A	CDKN2A_p + IKBKB_p	IKBKB_p \|CDKN2A → CDKN2A_p + IKBKB_p	V(33) = K(33,1) * [IKBKB_p \|CDKN2A];
R34	MAPK8_p + TP53	MAPK8_p \|TP53	MAPK8_p + TP53 → MAPK8_p \|TP53	V(34) = K(34,1) * [MAPK8_p] * [TP53] -K(34,2) * [MAPK8_p \|TP53];
R35	MAPK8_p \|TP53	MAPK8_p + TP53_p	MAPK8_p \|TP53 → MAPK8_p + TP53_p	V(35) = K(35,1) * [MAPK8_p \|TP53];
R36	MAPK8_p + MFN2	MAPK8_p \|MFN2	MAPK8_p + MFN2 → MAPK8_p \|MFN2	V(36) = K(36,1) * [MAPK8_p] * [MFN2] -K(36,2) * [MAPK8_p \|MFN2];
R37	MAPK8_p \|MFN2	MAPK8_p + MFN2_p	MAPK8_p \|MFN2 → MAPK8_p + MFN2_p	V(37) = K(37,1) * [MAPK8_p \|MFN2];
R38	ATR + PARP1	ATR \|PARP1	ATR + PARP1 → ATR \|PARP1	V(38) = K(38,1) * [ATR] * [PARP1] -K(38,2) * [ATR \|PARP1];
R39	ATR \|PARP1	ATR + PARP1_p	ATR \|PARP1 → ATR + PARP1_p	V(39) = K(39,1) * [ATR \|PARP1];
R40	FOXO1 + MAPK8_p	MAPK8_p \|FOXO1	FOXO1 + MAPK8_p → MAPK8_p \|FOXO1	V(40) = K(40,1) * [MAPK8_p] * [FOXO1] -K(40,2) * [MAPK8_p \|FOXO1];
R41	MAPK8_p \|FOXO1	FOXO1_p + MAPK8_p	MAPK8_p \|FOXO1 → FOXO1_p + MAPK8_p	V(41) = K(41,1) * [MAPK8_p \|FOXO1];
R42	JAK2_p + STAT1	JAK2_p \|STAT1	JAK2_p + STAT1 → JAK2_p \|STAT1	V(42) = K(42,1) * [JAK2_p] * [STAT1] -K(42,2) * [JAK2_p \|STAT1];
R43	JAK2_p \|STAT1	JAK2_p + STAT1_p	JAK2_p \|STAT1 → JAK2_p + STAT1_p	V(43) = K(43,1) * [JAK2_p \|STAT1];
R44	PDPK1_p + SGK1	PDPK1_p \|SGK1	PDPK1_p + SGK1 → PDPK1_p \|SGK1	V(44) = K(44,1) * [PDPK1_p] * [SGK1] -K(44,2) * [PDPK1_p \|SGK1];
R45	PDPK1_p \|SGK1	PDPK1_p + SGK1_p	PDPK1_p \|SGK1 → PDPK1_p + SGK1_p	V(45) = K(45,1) * [PDPK1_p \|SGK1];
R46	CALM1 + INSR_p	INSR_p \|CALM1	CALM1 + INSR_p → INSR_p \|CALM1	V(46) = K(46,1) * [INSR_p] * [CALM1] -K(46,2) * [INSR_p \|CALM1];
R47	INSR_p \|CALM1	CALM1_p + INSR_p	INSR_p \|CALM1 → CALM1_p + INSR_p	V(47) = K(47,1) * [INSR_p \|CALM1];
R48	ERN1 + ERN1_p	ERN1_p \|ERN1	ERN1 + ERN1_p → ERN1_p \|ERN1	V(48) = K(48,1) * [ERN1_p] * [ERN1] -K(48,2) * [ERN1_p \|ERN1];
R49	ERN1_p \|ERN1	ERN1_p + ERN1_p	ERN1_p \|ERN1 → ERN1_p + ERN1_p	V(49) = K(49,1) * [ERN1_p \|ERN1];
R50	AKT1 + MAPK8_p	MAPK8_p \|AKT1	AKT1 + MAPK8_p → MAPK8_p \|AKT1	V(50) = K(50,1) * [MAPK8_p] * [AKT1] -K(50,2) * [MAPK8_p \|AKT1];
R51	MAPK8_p \|AKT1	AKT1_p + MAPK8_p	MAPK8_p \|AKT1 → AKT1_p + MAPK8_p	V(51) = K(51,1) * [MAPK8_p \|AKT1];
R52	AKT1_p + CDKN1B	AKT1_p \|CDKN1B	AKT1_p + CDKN1B → AKT1_p \|CDKN1B	V(52) = K(52,1) * [AKT1_p] * [CDKN1B] -K(52,2) * [AKT1_p \|CDKN1B];
R53	AKT1_p \|CDKN1B	AKT1_p + CDKN1B_p	AKT1_p \|CDKN1B → AKT1_p + CDKN1B_p	V(53) = K(53,1) * [AKT1_p \|CDKN1B];
R54	CTNNB1 + MAPK8_p	MAPK8_p \|CTNNB1	CTNNB1 + MAPK8_p → MAPK8_p \|CTNNB1	V(54) = K(54,1) * [MAPK8_p] * [CTNNB1] -K(54,2) * [MAPK8_p \|CTNNB1];
R55	MAPK8_p \|CTNNB1	CTNNB1_p + MAPK8_p	MAPK8_p \|CTNNB1 → CTNNB1_p + MAPK8_p	V(55) = K(55,1) * [MAPK8_p \|CTNNB1];
R56	PINK1 + UBC	PINK1 \|UBC	PINK1 + UBC → PINK1 \|UBC	V(56) = K(56,1) * [PINK1] * [UBC] -K(56,2) * [PINK1 \|UBC];
R57	PINK1 \|UBC	PINK1 + UBC_p	PINK1 \|UBC → PINK1 + UBC_p	V(57) = K(57,1) * [PINK1 \|UBC];
R58	AKT1 + PDPK1_p	PDPK1_p \|AKT1	AKT1 + PDPK1_p → PDPK1_p \|AKT1	V(58) = K(58,1) * [PDPK1_p] * [AKT1] -K(58,2) * [PDPK1_p \|AKT1];
R59	PDPK1_p \|AKT1	AKT1_p + PDPK1_p	PDPK1_p \|AKT1 → AKT1_p + PDPK1_p	V(59) = K(59,1) * [PDPK1_p \|AKT1];
R60	IGF1R + IGF1R_p	IGF1R_p \|IGF1R	IGF1R + IGF1R_p → IGF1R_p \|IGF1R	V(60) = K(60,1) * [IGF1R_p] * [IGF1R] -K(60,2) * [IGF1R_p \|IGF1R];
R61	IGF1R_p \|IGF1R	IGF1R_p + IGF1R_p	IGF1R_p \|IGF1R → IGF1R_p + IGF1R_p	V(61) = K(61,1) * [IGF1R_p \|IGF1R];
R62	FOXO1 + SGK1_p	SGK1_p \|FOXO1	FOXO1 + SGK1_p → SGK1_p \|FOXO1	V(62) = K(62,1) * [SGK1_p] * [FOXO1] -K(62,2) * [SGK1_p \|FOXO1];
R63	SGK1_p \|FOXO1	FOXO1_p + SGK1_p	SGK1_p \|FOXO1 → FOXO1_p + SGK1_p	V(63) = K(63,1) * [SGK1_p \|FOXO1];
R64	HIPK2 + HIPK2_p	HIPK2_p \|HIPK2	HIPK2 + HIPK2_p → HIPK2_p \|HIPK2	V(64) = K(64,1) * [HIPK2_p] * [HIPK2] -K(64,2) * [HIPK2_p \|HIPK2];
R65	HIPK2_p \|HIPK2	HIPK2_p + HIPK2_p	HIPK2_p \|HIPK2 → HIPK2_p + HIPK2_p	V(65) = K(65,1) * [HIPK2_p \|HIPK2];
R66	PDPK1 + PDPK1_p	PDPK1_p \|PDPK1	PDPK1 + PDPK1_p → PDPK1_p \|PDPK1	V(66) = K(66,1) * [PDPK1_p] * [PDPK1] -K(66,2) * [PDPK1_p \|PDPK1];
R67	PDPK1_p \|PDPK1	PDPK1_p + PDPK1_p	PDPK1_p \|PDPK1 → PDPK1_p + PDPK1_p	V(67) = K(67,1) * [PDPK1_p \|PDPK1];
R68	CDKN1B + SGK1_p	SGK1_p \|CDKN1B	CDKN1B + SGK1_p → SGK1_p \|CDKN1B	V(68) = K(68,1) * [SGK1_p] * [CDKN1B] -K(68,2) * [SGK1_p \|CDKN1B];
R69	SGK1_p \|CDKN1B	CDKN1B_p + SGK1_p	SGK1_p \|CDKN1B → CDKN1B_p + SGK1_p	V(69) = K(69,1) * [SGK1_p \|CDKN1B];
R70	FOXO1 + IKBKB_p	IKBKB_p \|FOXO1	FOXO1 + IKBKB_p → IKBKB_p \|FOXO1	V(70) = K(70,1) * [IKBKB_p] * [FOXO1] -K(70,2) * [IKBKB_p \|FOXO1];
R71	IKBKB_p \|FOXO1	FOXO1_p + IKBKB_p	IKBKB_p \|FOXO1 → FOXO1_p + IKBKB_p	V(71) = K(71,1) * [IKBKB_p \|FOXO1];
R72	FYN + FYN_p	FYN_p \|FYN	FYN + FYN_p → FYN_p \|FYN	V(72) = K(72,1) * [FYN_p] * [FYN] -K(72,2) * [FYN_p \|FYN];
R73	FYN_p \|FYN	FYN_p + FYN_p	FYN_p \|FYN → FYN_p + FYN_p	V(73) = K(73,1) * [FYN_p \|FYN];
R74	MAPK8_p + STAT6	MAPK8_p \|STAT6	MAPK8_p + STAT6 → MAPK8_p \|STAT6	V(74) = K(74,1) * [MAPK8_p] * [STAT6] -K(74,2) * [MAPK8_p \|STAT6];
R75	MAPK8_p \|STAT6	MAPK8_p + STAT6_p	MAPK8_p \|STAT6 → MAPK8_p + STAT6_p	V(75) = K(75,1) * [MAPK8_p \|STAT6];
R76	AKT1_p + VIM	AKT1_p \|VIM	AKT1_p + VIM → AKT1_p \|VIM	V(76) = K(76,1) * [AKT1_p] * [VIM] -K(76,2) * [AKT1_p \|VIM];
R77	AKT1_p \|VIM	AKT1_p + VIM_p	AKT1_p \|VIM → AKT1_p + VIM_p	V(77) = K(77,1) * [AKT1_p \|VIM];
R78	AXL + AXL_p	AXL_p \|AXL	AXL + AXL_p → AXL_p \|AXL	V(78) = K(78,1) * [AXL_p] * [AXL] -K(78,2) * [AXL_p \|AXL];
R79	AXL_p \|AXL	AXL_p + AXL_p	AXL_p \|AXL → AXL_p + AXL_p	V(79) = K(79,1) * [AXL_p \|AXL];
R80	CDK5_p + TP53	CDK5_p \|TP53	CDK5_p + TP53 → CDK5_p \|TP53	V(80) = K(80,1) * [CDK5_p] * [TP53] -K(80,2) * [CDK5_p \|TP53];
R81	CDK5_p \|TP53	CDK5_p + TP53_p	CDK5_p \|TP53 → CDK5_p + TP53_p	V(81) = K(81,1) * [CDK5_p \|TP53];
R82	CDKN1A + MAPK8_p	MAPK8_p \|CDKN1A	CDKN1A + MAPK8_p → MAPK8_p \|CDKN1A	V(82) = K(82,1) * [MAPK8_p] * [CDKN1A] -K(82,2) * [MAPK8_p \|CDKN1A];
R83	MAPK8_p \|CDKN1A	CDKN1A_p + MAPK8_p	MAPK8_p \|CDKN1A → CDKN1A_p + MAPK8_p	V(83) = K(83,1) * [MAPK8_p \|CDKN1A];
R84	AKT1S1 + AKT1_p	AKT1_p \|AKT1S1	AKT1S1 + AKT1_p → AKT1_p \|AKT1S1	V(84) = K(84,1) * [AKT1_p] * [AKT1S1] -K(84,2) * [AKT1_p \|AKT1S1];
R85	AKT1_p \|AKT1S1	AKT1S1_p + AKT1_p	AKT1_p \|AKT1S1 → AKT1S1_p + AKT1_p	V(85) = K(85,1) * [AKT1_p \|AKT1S1];
R86	JUN + MAPK8_p	MAPK8_p \|JUN	JUN + MAPK8_p → MAPK8_p \|JUN	V(86) = K(86,1) * [MAPK8_p] * [JUN] -K(86,2) * [MAPK8_p \|JUN];
R87	MAPK8_p \|JUN	JUN_p + MAPK8_p	MAPK8_p \|JUN → JUN_p + MAPK8_p	V(87) = K(87,1) * [MAPK8_p \|JUN];
R88	JAK1_p + STAT3	JAK1_p \|STAT3	JAK1_p + STAT3 → JAK1_p \|STAT3	V(88) = K(88,1) * [JAK1_p] * [STAT3] -K(88,2) * [JAK1_p \|STAT3];
R89	JAK1_p \|STAT3	JAK1_p + STAT3_p	JAK1_p \|STAT3 → JAK1_p + STAT3_p	V(89) = K(89,1) * [JAK1_p \|STAT3];
R90	IGF1R_p + PDPK1	IGF1R_p \|PDPK1	IGF1R_p + PDPK1 → IGF1R_p \|PDPK1	V(90) = K(90,1) * [IGF1R_p] * [PDPK1] -K(90,2) * [IGF1R_p \|PDPK1];
R91	IGF1R_p \|PDPK1	IGF1R_p + PDPK1_p	IGF1R_p \|PDPK1 → IGF1R_p + PDPK1_p	V(91) = K(91,1) * [IGF1R_p \|PDPK1];
R92	JAK2_p + STAT6	JAK2_p \|STAT6	JAK2_p + STAT6 → JAK2_p \|STAT6	V(92) = K(92,1) * [JAK2_p] * [STAT6] -K(92,2) * [JAK2_p \|STAT6];
R93	JAK2_p \|STAT6	JAK2_p + STAT6_p	JAK2_p \|STAT6 → JAK2_p + STAT6_p	V(93) = K(93,1) * [JAK2_p \|STAT6];
R94	FOXO1 + PKN1_p	PKN1_p \|FOXO1	FOXO1 + PKN1_p → PKN1_p \|FOXO1	V(94) = K(94,1) * [PKN1_p] * [FOXO1] -K(94,2) * [PKN1_p \|FOXO1];
R95	PKN1_p \|FOXO1	FOXO1_p + PKN1_p	PKN1_p \|FOXO1 → FOXO1_p + PKN1_p	V(95) = K(95,1) * [PKN1_p \|FOXO1];
R96	MAPK8_p + SP1	MAPK8_p \|SP1	MAPK8_p + SP1 → MAPK8_p \|SP1	V(96) = K(96,1) * [MAPK8_p] * [SP1] -K(96,2) * [MAPK8_p \|SP1];
R97	MAPK8_p \|SP1	MAPK8_p + SP1_p	MAPK8_p \|SP1 → MAPK8_p + SP1_p	V(97) = K(97,1) * [MAPK8_p \|SP1];
R98	PLK2 + TP53	PLK2 \|TP53	PLK2 + TP53 → PLK2 \|TP53	V(98) = K(98,1) * [PLK2] * [TP53] -K(98,2) * [PLK2 \|TP53];
R99	PLK2 \|TP53	PLK2 + TP53_p	PLK2 \|TP53 → PLK2 + TP53_p	V(99) = K(99,1) * [PLK2 \|TP53];
R100	JAK1_p + STAT6	JAK1_p \|STAT6	JAK1_p + STAT6 → JAK1_p \|STAT6	V(100) = K(100,1) * [JAK1_p] * [STAT6] -K(100,2) * [JAK1_p \|STAT6];
R101	JAK1_p \|STAT6	JAK1_p + STAT6_p	JAK1_p \|STAT6 → JAK1_p + STAT6_p	V(101) = K(101,1) * [JAK1_p \|STAT6];
R102	IGF1R_p + IRS2	IGF1R_p \|IRS2	IGF1R_p + IRS2 → IGF1R_p \|IRS2	V(102) = K(102,1) * [IGF1R_p] * [IRS2] -K(102,2) * [IGF1R_p \|IRS2];
R103	IGF1R_p \|IRS2	IGF1R_p + IRS2_p	IGF1R_p \|IRS2 → IGF1R_p + IRS2_p	V(103) = K(103,1) * [IGF1R_p \|IRS2];
R104	CDKN1B + JAK2_p	JAK2_p \|CDKN1B	CDKN1B + JAK2_p → JAK2_p \|CDKN1B	V(104) = K(104,1) * [JAK2_p] * [CDKN1B] -K(104,2) * [JAK2_p \|CDKN1B];
R105	JAK2_p \|CDKN1B	CDKN1B_p + JAK2_p	JAK2_p \|CDKN1B → CDKN1B_p + JAK2_p	V(105) = K(105,1) * [JAK2_p \|CDKN1B];
R106	HIPK2_p + MECP2	HIPK2_p \|MECP2	HIPK2_p + MECP2 → HIPK2_p \|MECP2	V(106) = K(106,1) * [HIPK2_p] * [MECP2] -K(106,2) * [HIPK2_p \|MECP2];
R107	HIPK2_p \|MECP2	HIPK2_p + MECP2_p	HIPK2_p \|MECP2 → HIPK2_p + MECP2_p	V(107) = K(107,1) * [HIPK2_p \|MECP2];
R108	AKT1_p + CTNNB1	AKT1_p \|CTNNB1	AKT1_p + CTNNB1 → AKT1_p \|CTNNB1	V(108) = K(108,1) * [AKT1_p] * [CTNNB1] -K(108,2) * [AKT1_p \|CTNNB1];
R109	AKT1_p \|CTNNB1	AKT1_p + CTNNB1_p	AKT1_p \|CTNNB1 → AKT1_p + CTNNB1_p	V(109) = K(109,1) * [AKT1_p \|CTNNB1];
R110	JUNB + MAPK8_p	MAPK8_p \|JUNB	JUNB + MAPK8_p → MAPK8_p \|JUNB	V(110) = K(110,1) * [MAPK8_p] * [JUNB] -K(110,2) * [MAPK8_p \|JUNB];
R111	MAPK8_p \|JUNB	JUNB_p + MAPK8_p	MAPK8_p \|JUNB → JUNB_p + MAPK8_p	V(111) = K(111,1) * [MAPK8_p \|JUNB];
R112	CDK5_p + PARP1	CDK5_p \|PARP1	CDK5_p + PARP1 → CDK5_p \|PARP1	V(112) = K(112,1) * [CDK5_p] * [PARP1] -K(112,2) * [CDK5_p \|PARP1];
R113	CDK5_p \|PARP1	CDK5_p + PARP1_p	CDK5_p \|PARP1 → CDK5_p + PARP1_p	V(113) = K(113,1) * [CDK5_p \|PARP1];
R114	LYN + LYN_p	LYN_p \|LYN	LYN + LYN_p → LYN_p \|LYN	V(114) = K(114,1) * [LYN_p] * [LYN] -K(114,2) * [LYN_p \|LYN];
R115	LYN_p \|LYN	LYN_p + LYN_p	LYN_p \|LYN → LYN_p + LYN_p	V(115) = K(115,1) * [LYN_p \|LYN];
R116	AKT1_p + MAPKAP1	AKT1_p \|MAPKAP1	AKT1_p + MAPKAP1 → AKT1_p \|MAPKAP1	V(116) = K(116,1) * [AKT1_p] * [MAPKAP1] -K(116,2) * [AKT1_p \|MAPKAP1];
R117	AKT1_p \|MAPKAP1	AKT1_p + MAPKAP1_p	AKT1_p \|MAPKAP1 → AKT1_p + MAPKAP1_p	V(117) = K(117,1) * [AKT1_p \|MAPKAP1];
R118	FYN_p + PTPRJ	FYN_p \|PTPRJ	FYN_p + PTPRJ → FYN_p \|PTPRJ	V(118) = K(118,1) * [FYN_p] * [PTPRJ] -K(118,2) * [FYN_p \|PTPRJ];
R119	FYN_p \|PTPRJ	FYN_p + PTPRJ_p	FYN_p \|PTPRJ → FYN_p + PTPRJ_p	V(119) = K(119,1) * [FYN_p \|PTPRJ];
R120	AKT1_p + PARK7	AKT1_p \|PARK7	AKT1_p + PARK7 → AKT1_p \|PARK7	V(120) = K(120,1) * [AKT1_p] * [PARK7] -K(120,2) * [AKT1_p \|PARK7];
R121	AKT1_p \|PARK7	AKT1_p + PARK7_p	AKT1_p \|PARK7 → AKT1_p + PARK7_p	V(121) = K(121,1) * [AKT1_p \|PARK7];
R122	SGK1_p + SP1	SGK1_p \|SP1	SGK1_p + SP1 → SGK1_p \|SP1	V(122) = K(122,1) * [SGK1_p] * [SP1] -K(122,2) * [SGK1_p \|SP1];
R123	SGK1_p \|SP1	SGK1_p + SP1_p	SGK1_p \|SP1 → SGK1_p + SP1_p	V(123) = K(123,1) * [SGK1_p \|SP1];
R124	PDPK1_p + PKN1	PDPK1_p \|PKN1	PDPK1_p + PKN1 → PDPK1_p \|PKN1	V(124) = K(124,1) * [PDPK1_p] * [PKN1] -K(124,2) * [PDPK1_p \|PKN1];
R125	PDPK1_p \|PKN1	PDPK1_p + PKN1_p	PDPK1_p \|PKN1 → PDPK1_p + PKN1_p	V(125) = K(125,1) * [PDPK1_p \|PKN1];
R126	INSR_p + IRS2	INSR_p \|IRS2	INSR_p + IRS2 → INSR_p \|IRS2	V(126) = K(126,1) * [INSR_p] * [IRS2] -K(126,2) * [INSR_p \|IRS2];
R127	INSR_p \|IRS2	INSR_p + IRS2_p	INSR_p \|IRS2 → INSR_p + IRS2_p	V(127) = K(127,1) * [INSR_p \|IRS2];
R128	GHR + JAK2_p	JAK2_p \|GHR	GHR + JAK2_p → JAK2_p \|GHR	V(128) = K(128,1) * [JAK2_p] * [GHR] -K(128,2) * [JAK2_p \|GHR];
R129	JAK2_p \|GHR	GHR_p + JAK2_p	JAK2_p \|GHR → GHR_p + JAK2_p	V(129) = K(129,1) * [JAK2_p \|GHR];
R130	CDK5_p + NOTCH1	CDK5_p \|NOTCH1	CDK5_p + NOTCH1 → CDK5_p \|NOTCH1	V(130) = K(130,1) * [CDK5_p] * [NOTCH1] -K(130,2) * [CDK5_p \|NOTCH1];
R131	CDK5_p \|NOTCH1	CDK5_p + NOTCH1_p	CDK5_p \|NOTCH1 → CDK5_p + NOTCH1_p	V(131) = K(131,1) * [CDK5_p \|NOTCH1];
R132	CDK5_p + CREB1	CDK5_p \|CREB1	CDK5_p + CREB1 → CDK5_p \|CREB1	V(132) = K(132,1) * [CDK5_p] * [CREB1] -K(132,2) * [CDK5_p \|CREB1];
R133	CDK5_p \|CREB1	CDK5_p + CREB1_p	CDK5_p \|CREB1 → CDK5_p + CREB1_p	V(133) = K(133,1) * [CDK5_p \|CREB1];
R134	JAK2_p + LEPR	JAK2_p \|LEPR	JAK2_p + LEPR → JAK2_p \|LEPR	V(134) = K(134,1) * [JAK2_p] * [LEPR] -K(134,2) * [JAK2_p \|LEPR];
R135	JAK2_p \|LEPR	JAK2_p + LEPR_p	JAK2_p \|LEPR → JAK2_p + LEPR_p	V(135) = K(135,1) * [JAK2_p \|LEPR];
R136	CDK5_p + PIK3C3	CDK5_p \|PIK3C3	CDK5_p + PIK3C3 → CDK5_p \|PIK3C3	V(136) = K(136,1) * [CDK5_p] * [PIK3C3] -K(136,2) * [CDK5_p \|PIK3C3];
R137	CDK5_p \|PIK3C3	CDK5_p + PIK3C3_p	CDK5_p \|PIK3C3 → CDK5_p + PIK3C3_p	V(137) = K(137,1) * [CDK5_p \|PIK3C3];
R138	AKT1 + AKT1_p	AKT1_p \|AKT1	AKT1 + AKT1_p → AKT1_p \|AKT1	V(138) = K(138,1) * [AKT1_p] * [AKT1] -K(138,2) * [AKT1_p \|AKT1];
R139	AKT1_p \|AKT1	AKT1_p + AKT1_p	AKT1_p \|AKT1 → AKT1_p + AKT1_p	V(139) = K(139,1) * [AKT1_p \|AKT1];
R140	INSR_p + PTPN6	INSR_p \|PTPN6	INSR_p + PTPN6 → INSR_p \|PTPN6	V(140) = K(140,1) * [INSR_p] * [PTPN6] -K(140,2) * [INSR_p \|PTPN6];
R141	INSR_p \|PTPN6	INSR_p + PTPN6_p	INSR_p \|PTPN6 → INSR_p + PTPN6_p	V(141) = K(141,1) * [INSR_p \|PTPN6];
R142	PINK1 + TP53	PINK1 \|TP53	PINK1 + TP53 → PINK1 \|TP53	V(142) = K(142,1) * [PINK1] * [TP53] -K(142,2) * [PINK1 \|TP53];
R143	PINK1 \|TP53	PINK1 + TP53_p	PINK1 \|TP53 → PINK1 + TP53_p	V(143) = K(143,1) * [PINK1 \|TP53];
R144	JAK2_p + STAT3	JAK2_p \|STAT3	JAK2_p + STAT3 → JAK2_p \|STAT3	V(144) = K(144,1) * [JAK2_p] * [STAT3] -K(144,2) * [JAK2_p \|STAT3];
R145	JAK2_p \|STAT3	JAK2_p + STAT3_p	JAK2_p \|STAT3 → JAK2_p + STAT3_p	V(145) = K(145,1) * [JAK2_p \|STAT3];
R146	INSR_p + PTEN	INSR_p \|PTEN	INSR_p + PTEN → INSR_p \|PTEN	V(146) = K(146,1) * [INSR_p] * [PTEN] -K(146,2) * [INSR_p \|PTEN];
R147	INSR_p \|PTEN	INSR_p + PTEN_p	INSR_p \|PTEN → INSR_p + PTEN_p	V(147) = K(147,1) * [INSR_p \|PTEN];
R148	INSR_p + PIK3R1	INSR_p \|PIK3R1	INSR_p + PIK3R1 → INSR_p \|PIK3R1	V(148) = K(148,1) * [INSR_p] * [PIK3R1] -K(148,2) * [INSR_p \|PIK3R1];
R149	INSR_p \|PIK3R1	INSR_p + PIK3R1_p	INSR_p \|PIK3R1 → INSR_p + PIK3R1_p	V(149) = K(149,1) * [INSR_p \|PIK3R1];
R150	MAPK8_p + STAT3	MAPK8_p \|STAT3	MAPK8_p + STAT3 → MAPK8_p \|STAT3	V(150) = K(150,1) * [MAPK8_p] * [STAT3] -K(150,2) * [MAPK8_p \|STAT3];
R151	MAPK8_p \|STAT3	MAPK8_p + STAT3_p	MAPK8_p \|STAT3 → MAPK8_p + STAT3_p	V(151) = K(151,1) * [MAPK8_p \|STAT3];
R152	GLO1 + LYN_p	LYN_p \|GLO1	GLO1 + LYN_p → LYN_p \|GLO1	V(152) = K(152,1) * [LYN_p] * [GLO1] -K(152,2) * [LYN_p \|GLO1];
R153	LYN_p \|GLO1	GLO1_p + LYN_p	LYN_p \|GLO1 → GLO1_p + LYN_p	V(153) = K(153,1) * [LYN_p \|GLO1];
R154	CDK5_p + STAT3	CDK5_p \|STAT3	CDK5_p + STAT3 → CDK5_p \|STAT3	V(154) = K(154,1) * [CDK5_p] * [STAT3] -K(154,2) * [CDK5_p \|STAT3];
R155	CDK5_p \|STAT3	CDK5_p + STAT3_p	CDK5_p \|STAT3 → CDK5_p + STAT3_p	V(155) = K(155,1) * [CDK5_p \|STAT3];
R156	AKT1_p + CREB1	AKT1_p \|CREB1	AKT1_p + CREB1 → AKT1_p \|CREB1	V(156) = K(156,1) * [AKT1_p] * [CREB1] -K(156,2) * [AKT1_p \|CREB1];
R157	AKT1_p \|CREB1	AKT1_p + CREB1_p	AKT1_p \|CREB1 → AKT1_p + CREB1_p	V(157) = K(157,1) * [AKT1_p \|CREB1];
R158	MFN2 + PINK1	PINK1 \|MFN2	MFN2 + PINK1 → PINK1 \|MFN2	V(158) = K(158,1) * [PINK1] * [MFN2] -K(158,2) * [PINK1 \|MFN2];
R159	PINK1 \|MFN2	MFN2_p + PINK1	PINK1 \|MFN2 → MFN2_p + PINK1	V(159) = K(159,1) * [PINK1 \|MFN2];
R160	MAPK8_p + STAT1	MAPK8_p \|STAT1	MAPK8_p + STAT1 → MAPK8_p \|STAT1	V(160) = K(160,1) * [MAPK8_p] * [STAT1] -K(160,2) * [MAPK8_p \|STAT1];
R161	MAPK8_p \|STAT1	MAPK8_p + STAT1_p	MAPK8_p \|STAT1 → MAPK8_p + STAT1_p	V(161) = K(161,1) * [MAPK8_p \|STAT1];
R162	CDK5 + FYN_p	FYN_p \|CDK5	CDK5 + FYN_p → FYN_p \|CDK5	V(162) = K(162,1) * [FYN_p] * [CDK5] -K(162,2) * [FYN_p \|CDK5];
R163	FYN_p \|CDK5	CDK5_p + FYN_p	FYN_p \|CDK5 → CDK5_p + FYN_p	V(163) = K(163,1) * [FYN_p \|CDK5];
R164	CDKN1B + LYN_p	LYN_p \|CDKN1B	CDKN1B + LYN_p → LYN_p \|CDKN1B	V(164) = K(164,1) * [LYN_p] * [CDKN1B] -K(164,2) * [LYN_p \|CDKN1B];
R165	LYN_p \|CDKN1B	CDKN1B_p + LYN_p	LYN_p \|CDKN1B → CDKN1B_p + LYN_p	V(165) = K(165,1) * [LYN_p \|CDKN1B];
R166	IKBKB_p + TP53	IKBKB_p \|TP53	IKBKB_p + TP53 → IKBKB_p \|TP53	V(166) = K(166,1) * [IKBKB_p] * [TP53] -K(166,2) * [IKBKB_p \|TP53];
R167	IKBKB_p \|TP53	IKBKB_p + TP53_p	IKBKB_p \|TP53 → IKBKB_p + TP53_p	V(167) = K(167,1) * [IKBKB_p \|TP53];
R168	MAPK8_p + NR4A1	MAPK8_p \|NR4A1	MAPK8_p + NR4A1 → MAPK8_p \|NR4A1	V(168) = K(168,1) * [MAPK8_p] * [NR4A1] -K(168,2) * [MAPK8_p \|NR4A1];
R169	MAPK8_p \|NR4A1	MAPK8_p + NR4A1_p	MAPK8_p \|NR4A1 → MAPK8_p + NR4A1_p	V(169) = K(169,1) * [MAPK8_p \|NR4A1];
R170	ATR + TP53	ATR \|TP53	ATR + TP53 → ATR \|TP53	V(170) = K(170,1) * [ATR] * [TP53] -K(170,2) * [ATR \|TP53];
R171	ATR \|TP53	ATR + TP53_p	ATR \|TP53 → ATR + TP53_p	V(171) = K(171,1) * [ATR \|TP53];
R172	ATR + CREB1	ATR \|CREB1	ATR + CREB1 → ATR \|CREB1	V(172) = K(172,1) * [ATR] * [CREB1] -K(172,2) * [ATR \|CREB1];
R173	ATR \|CREB1	ATR + CREB1_p	ATR \|CREB1 → ATR + CREB1_p	V(173) = K(173,1) * [ATR \|CREB1];
R174	CTNNB1 + FYN_p	FYN_p \|CTNNB1	CTNNB1 + FYN_p → FYN_p \|CTNNB1	V(174) = K(174,1) * [FYN_p] * [CTNNB1] -K(174,2) * [FYN_p \|CTNNB1];
R175	FYN_p \|CTNNB1	CTNNB1_p + FYN_p	FYN_p \|CTNNB1 → CTNNB1_p + FYN_p	V(175) = K(175,1) * [FYN_p \|CTNNB1];
R176	LYN_p + STAT3	LYN_p \|STAT3	LYN_p + STAT3 → LYN_p \|STAT3	V(176) = K(176,1) * [LYN_p] * [STAT3] -K(176,2) * [LYN_p \|STAT3];
R177	LYN_p \|STAT3	LYN_p + STAT3_p	LYN_p \|STAT3 → LYN_p + STAT3_p	V(177) = K(177,1) * [LYN_p \|STAT3];
R178	CDKN1B + HIPK2_p	HIPK2_p \|CDKN1B	CDKN1B + HIPK2_p → HIPK2_p \|CDKN1B	V(178) = K(178,1) * [HIPK2_p] * [CDKN1B] -K(178,2) * [HIPK2_p \|CDKN1B];
R179	HIPK2_p \|CDKN1B	CDKN1B_p + HIPK2_p	HIPK2_p \|CDKN1B → CDKN1B_p + HIPK2_p	V(179) = K(179,1) * [HIPK2_p \|CDKN1B];
R180	HIPK2_p + TP53	HIPK2_p \|TP53	HIPK2_p + TP53 → HIPK2_p \|TP53	V(180) = K(180,1) * [HIPK2_p] * [TP53] -K(180,2) * [HIPK2_p \|TP53];
R181	HIPK2_p \|TP53	HIPK2_p + TP53_p	HIPK2_p \|TP53 → HIPK2_p + TP53_p	V(181) = K(181,1) * [HIPK2_p \|TP53];
R182	SGK1_p + STAT1	SGK1_p \|STAT1	SGK1_p + STAT1 → SGK1_p \|STAT1	V(182) = K(182,1) * [SGK1_p] * [STAT1] -K(182,2) * [SGK1_p \|STAT1];
R183	SGK1_p \|STAT1	SGK1_p + STAT1_p	SGK1_p \|STAT1 → SGK1_p + STAT1_p	V(183) = K(183,1) * [SGK1_p \|STAT1];
R184	LEPR_p + STAT3	LEPR_p \|STAT3	LEPR_p + STAT3 → LEPR_p \|STAT3	V(184) = K(184,1) * [LEPR_p] * [STAT3] -K(184,2) * [LEPR_p \|STAT3];
R185	LEPR_p \|STAT3	LEPR_p + STAT3_p	LEPR_p \|STAT3 → LEPR_p + STAT3_p	V(185) = K(185,1) * [LEPR_p \|STAT3];
R186	CDK5_p + CDKN1B	CDK5_p \|CDKN1B	CDK5_p + CDKN1B → CDK5_p \|CDKN1B	V(186) = K(186,1) * [CDK5_p] * [CDKN1B] -K(186,2) * [CDK5_p \|CDKN1B];
R187	CDK5_p \|CDKN1B	CDK5_p + CDKN1B_p	CDK5_p \|CDKN1B → CDK5_p + CDKN1B_p	V(187) = K(187,1) * [CDK5_p \|CDKN1B];
R188	CDK5_p + VIM	CDK5_p \|VIM	CDK5_p + VIM → CDK5_p \|VIM	V(188) = K(188,1) * [CDK5_p] * [VIM] -K(188,2) * [CDK5_p \|VIM];
R189	CDK5_p \|VIM	CDK5_p + VIM_p	CDK5_p \|VIM → CDK5_p + VIM_p	V(189) = K(189,1) * [CDK5_p \|VIM];
R190	CDK5_p + HIF1A	CDK5_p \|HIF1A	CDK5_p + HIF1A → CDK5_p \|HIF1A	V(190) = K(190,1) * [CDK5_p] * [HIF1A] -K(190,2) * [CDK5_p \|HIF1A];
R191	CDK5_p \|HIF1A	CDK5_p + HIF1A_p	CDK5_p \|HIF1A → CDK5_p + HIF1A_p	V(191) = K(191,1) * [CDK5_p \|HIF1A];
R192	CDK5_p + CTNNB1	CDK5_p \|CTNNB1	CDK5_p + CTNNB1 → CDK5_p \|CTNNB1	V(192) = K(192,1) * [CDK5_p] * [CTNNB1] -K(192,2) * [CDK5_p \|CTNNB1];
R193	CDK5_p \|CTNNB1	CDK5_p + CTNNB1_p	CDK5_p \|CTNNB1 → CDK5_p + CTNNB1_p	V(193) = K(193,1) * [CDK5_p \|CTNNB1];
R194	CDK5_p + SIRT2	CDK5_p \|SIRT2	CDK5_p + SIRT2 → CDK5_p \|SIRT2	V(194) = K(194,1) * [CDK5_p] * [SIRT2] -K(194,2) * [CDK5_p \|SIRT2];
R195	CDK5_p \|SIRT2	CDK5_p + SIRT2_p	CDK5_p \|SIRT2 → CDK5_p + SIRT2_p	V(195) = K(195,1) * [CDK5_p \|SIRT2];
R196	EZH2 + JAK2_p	JAK2_p \|EZH2	EZH2 + JAK2_p → JAK2_p \|EZH2	V(196) = K(196,1) * [JAK2_p] * [EZH2] -K(196,2) * [JAK2_p \|EZH2];
R197	JAK2_p \|EZH2	EZH2_p + JAK2_p	JAK2_p \|EZH2 → EZH2_p + JAK2_p	V(197) = K(197,1) * [JAK2_p \|EZH2];
R198	PINK1 + PTEN	PINK1 \|PTEN	PINK1 + PTEN → PINK1 \|PTEN	V(198) = K(198,1) * [PINK1] * [PTEN] -K(198,2) * [PINK1 \|PTEN];
R199	PINK1 \|PTEN	PINK1 + PTEN_p	PINK1 \|PTEN → PINK1 + PTEN_p	V(199) = K(199,1) * [PINK1 \|PTEN];

Reaction ID	Reactants	Products	Original Text	ODE Equations
R1	SP1_p + STAT3_p	SIGNOR-C74	SP1_p + STAT3_p → SIGNOR-C74	V(1) = K(1,1) * [STAT3_p] * [SP1_p] -K(1,2) * [SIGNOR-C74];
R2	STAT1_p + STAT3_p	SIGNOR-C118	STAT1_p + STAT3_p → SIGNOR-C118	V(2) = K(2,1) * [STAT1_p] * [STAT3_p] -K(2,2) * [SIGNOR-C118];
R3	JAK1_p + SIGNOR-C118_p	SIGNOR-C120	JAK1_p + SIGNOR-C118_p → SIGNOR-C120	V(3) = K(3,1) * [SIGNOR-C118_p] * [JAK1_p] -K(3,2) * [SIGNOR-C120];
R4	SMAD2 + TGFBR1	TGFBR1 \|SMAD2	SMAD2 + TGFBR1 → TGFBR1 \|SMAD2	V(4) = K(4,1) * [TGFBR1] * [SMAD2] -K(4,2) * [TGFBR1 \|SMAD2];
R5	TGFBR1 \|SMAD2	SMAD2_p + TGFBR1	TGFBR1 \|SMAD2 → SMAD2_p + TGFBR1	V(5) = K(5,1) * [TGFBR1 \|SMAD2];
R6	AKT1_p + FOXO1	AKT1_p \|FOXO1	AKT1_p + FOXO1 → AKT1_p \|FOXO1	V(6) = K(6,1) * [AKT1_p] * [FOXO1] -K(6,2) * [AKT1_p \|FOXO1];
R7	AKT1_p \|FOXO1	AKT1_p + FOXO1_p	AKT1_p \|FOXO1 → AKT1_p + FOXO1_p	V(7) = K(7,1) * [AKT1_p \|FOXO1];
R8	JAK2_p + STAT5A	JAK2_p \|STAT5A	JAK2_p + STAT5A → JAK2_p \|STAT5A	V(8) = K(8,1) * [JAK2_p] * [STAT5A] -K(8,2) * [JAK2_p \|STAT5A];
R9	JAK2_p \|STAT5A	JAK2_p + STAT5A_p	JAK2_p \|STAT5A → JAK2_p + STAT5A_p	V(9) = K(9,1) * [JAK2_p \|STAT5A];
R10	IKBKB + IKBKB_p	IKBKB_p \|IKBKB	IKBKB + IKBKB_p → IKBKB_p \|IKBKB	V(10) = K(10,1) * [IKBKB_p] * [IKBKB] -K(10,2) * [IKBKB_p \|IKBKB];
R11	IKBKB_p \|IKBKB	IKBKB_p + IKBKB_p	IKBKB_p \|IKBKB → IKBKB_p + IKBKB_p	V(11) = K(11,1) * [IKBKB_p \|IKBKB];
R12	JAK2 + JAK2_p	JAK2_p \|JAK2	JAK2 + JAK2_p → JAK2_p \|JAK2	V(12) = K(12,1) * [JAK2_p] * [JAK2] -K(12,2) * [JAK2_p \|JAK2];
R13	JAK2_p \|JAK2	JAK2_p + JAK2_p	JAK2_p \|JAK2 → JAK2_p + JAK2_p	V(13) = K(13,1) * [JAK2_p \|JAK2];
R14	AKT1_p + EZH2	AKT1_p \|EZH2	AKT1_p + EZH2 → AKT1_p \|EZH2	V(14) = K(14,1) * [AKT1_p] * [EZH2] -K(14,2) * [AKT1_p \|EZH2];
R15	AKT1_p \|EZH2	AKT1_p + EZH2_p	AKT1_p \|EZH2 → AKT1_p + EZH2_p	V(15) = K(15,1) * [AKT1_p \|EZH2];
R16	IKBKB + PDPK1_p	PDPK1_p \|IKBKB	IKBKB + PDPK1_p → PDPK1_p \|IKBKB	V(16) = K(16,1) * [PDPK1_p] * [IKBKB] -K(16,2) * [PDPK1_p \|IKBKB];
R17	PDPK1_p \|IKBKB	IKBKB_p + PDPK1_p	PDPK1_p \|IKBKB → IKBKB_p + PDPK1_p	V(17) = K(17,1) * [PDPK1_p \|IKBKB];
R18	AKT1_p + NR4A1	AKT1_p \|NR4A1	AKT1_p + NR4A1 → AKT1_p \|NR4A1	V(18) = K(18,1) * [AKT1_p] * [NR4A1] -K(18,2) * [AKT1_p \|NR4A1];
R19	AKT1_p \|NR4A1	AKT1_p + NR4A1_p	AKT1_p \|NR4A1 → AKT1_p + NR4A1_p	V(19) = K(19,1) * [AKT1_p \|NR4A1];
R20	FYN_p + PTPN6	FYN_p \|PTPN6	FYN_p + PTPN6 → FYN_p \|PTPN6	V(20) = K(20,1) * [FYN_p] * [PTPN6] -K(20,2) * [FYN_p \|PTPN6];
R21	FYN_p \|PTPN6	FYN_p + PTPN6_p	FYN_p \|PTPN6 → FYN_p + PTPN6_p	V(21) = K(21,1) * [FYN_p \|PTPN6];
R22	INSR + INSR_p	INSR_p \|INSR	INSR + INSR_p → INSR_p \|INSR	V(22) = K(22,1) * [INSR_p] * [INSR] -K(22,2) * [INSR_p \|INSR];
R23	INSR_p \|INSR	INSR_p + INSR_p	INSR_p \|INSR → INSR_p + INSR_p	V(23) = K(23,1) * [INSR_p \|INSR];
R24	JAK1_p + STAT1	JAK1_p \|STAT1	JAK1_p + STAT1 → JAK1_p \|STAT1	V(24) = K(24,1) * [JAK1_p] * [STAT1] -K(24,2) * [JAK1_p \|STAT1];
R25	JAK1_p \|STAT1	JAK1_p + STAT1_p	JAK1_p \|STAT1 → JAK1_p + STAT1_p	V(25) = K(25,1) * [JAK1_p \|STAT1];
R26	AKT1_p + HSPB1	AKT1_p \|HSPB1	AKT1_p + HSPB1 → AKT1_p \|HSPB1	V(26) = K(26,1) * [AKT1_p] * [HSPB1] -K(26,2) * [AKT1_p \|HSPB1];
R27	AKT1_p \|HSPB1	AKT1_p + HSPB1_p	AKT1_p \|HSPB1 → AKT1_p + HSPB1_p	V(27) = K(27,1) * [AKT1_p \|HSPB1];
R28	PKN1 + PKN1_p	PKN1_p \|PKN1	PKN1 + PKN1_p → PKN1_p \|PKN1	V(28) = K(28,1) * [PKN1_p] * [PKN1] -K(28,2) * [PKN1_p \|PKN1];
R29	PKN1_p \|PKN1	PKN1_p + PKN1_p	PKN1_p \|PKN1 → PKN1_p + PKN1_p	V(29) = K(29,1) * [PKN1_p \|PKN1];
R30	AKT1_p + CDKN1A	AKT1_p \|CDKN1A	AKT1_p + CDKN1A → AKT1_p \|CDKN1A	V(30) = K(30,1) * [AKT1_p] * [CDKN1A] -K(30,2) * [AKT1_p \|CDKN1A];
R31	AKT1_p \|CDKN1A	AKT1_p + CDKN1A_p	AKT1_p \|CDKN1A → AKT1_p + CDKN1A_p	V(31) = K(31,1) * [AKT1_p \|CDKN1A];
R32	CDKN2A + IKBKB_p	IKBKB_p \|CDKN2A	CDKN2A + IKBKB_p → IKBKB_p \|CDKN2A	V(32) = K(32,1) * [IKBKB_p] * [CDKN2A] -K(32,2) * [IKBKB_p \|CDKN2A];
R33	IKBKB_p \|CDKN2A	CDKN2A_p + IKBKB_p	IKBKB_p \|CDKN2A → CDKN2A_p + IKBKB_p	V(33) = K(33,1) * [IKBKB_p \|CDKN2A];
R34	MAPK8_p + TP53	MAPK8_p \|TP53	MAPK8_p + TP53 → MAPK8_p \|TP53	V(34) = K(34,1) * [MAPK8_p] * [TP53] -K(34,2) * [MAPK8_p \|TP53];
R35	MAPK8_p \|TP53	MAPK8_p + TP53_p	MAPK8_p \|TP53 → MAPK8_p + TP53_p	V(35) = K(35,1) * [MAPK8_p \|TP53];
R36	MAPK8_p + MFN2	MAPK8_p \|MFN2	MAPK8_p + MFN2 → MAPK8_p \|MFN2	V(36) = K(36,1) * [MAPK8_p] * [MFN2] -K(36,2) * [MAPK8_p \|MFN2];
R37	MAPK8_p \|MFN2	MAPK8_p + MFN2_p	MAPK8_p \|MFN2 → MAPK8_p + MFN2_p	V(37) = K(37,1) * [MAPK8_p \|MFN2];
R38	ATR + PARP1	ATR \|PARP1	ATR + PARP1 → ATR \|PARP1	V(38) = K(38,1) * [ATR] * [PARP1] -K(38,2) * [ATR \|PARP1];
R39	ATR \|PARP1	ATR + PARP1_p	ATR \|PARP1 → ATR + PARP1_p	V(39) = K(39,1) * [ATR \|PARP1];
R40	FOXO1 + MAPK8_p	MAPK8_p \|FOXO1	FOXO1 + MAPK8_p → MAPK8_p \|FOXO1	V(40) = K(40,1) * [MAPK8_p] * [FOXO1] -K(40,2) * [MAPK8_p \|FOXO1];
R41	MAPK8_p \|FOXO1	FOXO1_p + MAPK8_p	MAPK8_p \|FOXO1 → FOXO1_p + MAPK8_p	V(41) = K(41,1) * [MAPK8_p \|FOXO1];
R42	JAK2_p + STAT1	JAK2_p \|STAT1	JAK2_p + STAT1 → JAK2_p \|STAT1	V(42) = K(42,1) * [JAK2_p] * [STAT1] -K(42,2) * [JAK2_p \|STAT1];
R43	JAK2_p \|STAT1	JAK2_p + STAT1_p	JAK2_p \|STAT1 → JAK2_p + STAT1_p	V(43) = K(43,1) * [JAK2_p \|STAT1];
R44	PDPK1_p + SGK1	PDPK1_p \|SGK1	PDPK1_p + SGK1 → PDPK1_p \|SGK1	V(44) = K(44,1) * [PDPK1_p] * [SGK1] -K(44,2) * [PDPK1_p \|SGK1];
R45	PDPK1_p \|SGK1	PDPK1_p + SGK1_p	PDPK1_p \|SGK1 → PDPK1_p + SGK1_p	V(45) = K(45,1) * [PDPK1_p \|SGK1];
R46	CALM1 + INSR_p	INSR_p \|CALM1	CALM1 + INSR_p → INSR_p \|CALM1	V(46) = K(46,1) * [INSR_p] * [CALM1] -K(46,2) * [INSR_p \|CALM1];
R47	INSR_p \|CALM1	CALM1_p + INSR_p	INSR_p \|CALM1 → CALM1_p + INSR_p	V(47) = K(47,1) * [INSR_p \|CALM1];
R48	ERN1 + ERN1_p	ERN1_p \|ERN1	ERN1 + ERN1_p → ERN1_p \|ERN1	V(48) = K(48,1) * [ERN1_p] * [ERN1] -K(48,2) * [ERN1_p \|ERN1];
R49	ERN1_p \|ERN1	ERN1_p + ERN1_p	ERN1_p \|ERN1 → ERN1_p + ERN1_p	V(49) = K(49,1) * [ERN1_p \|ERN1];
R50	AKT1 + MAPK8_p	MAPK8_p \|AKT1	AKT1 + MAPK8_p → MAPK8_p \|AKT1	V(50) = K(50,1) * [MAPK8_p] * [AKT1] -K(50,2) * [MAPK8_p \|AKT1];
R51	MAPK8_p \|AKT1	AKT1_p + MAPK8_p	MAPK8_p \|AKT1 → AKT1_p + MAPK8_p	V(51) = K(51,1) * [MAPK8_p \|AKT1];
R52	AKT1_p + CDKN1B	AKT1_p \|CDKN1B	AKT1_p + CDKN1B → AKT1_p \|CDKN1B	V(52) = K(52,1) * [AKT1_p] * [CDKN1B] -K(52,2) * [AKT1_p \|CDKN1B];
R53	AKT1_p \|CDKN1B	AKT1_p + CDKN1B_p	AKT1_p \|CDKN1B → AKT1_p + CDKN1B_p	V(53) = K(53,1) * [AKT1_p \|CDKN1B];
R54	CTNNB1 + MAPK8_p	MAPK8_p \|CTNNB1	CTNNB1 + MAPK8_p → MAPK8_p \|CTNNB1	V(54) = K(54,1) * [MAPK8_p] * [CTNNB1] -K(54,2) * [MAPK8_p \|CTNNB1];
R55	MAPK8_p \|CTNNB1	CTNNB1_p + MAPK8_p	MAPK8_p \|CTNNB1 → CTNNB1_p + MAPK8_p	V(55) = K(55,1) * [MAPK8_p \|CTNNB1];
R56	PINK1 + UBC	PINK1 \|UBC	PINK1 + UBC → PINK1 \|UBC	V(56) = K(56,1) * [PINK1] * [UBC] -K(56,2) * [PINK1 \|UBC];
R57	PINK1 \|UBC	PINK1 + UBC_p	PINK1 \|UBC → PINK1 + UBC_p	V(57) = K(57,1) * [PINK1 \|UBC];
R58	AKT1 + PDPK1_p	PDPK1_p \|AKT1	AKT1 + PDPK1_p → PDPK1_p \|AKT1	V(58) = K(58,1) * [PDPK1_p] * [AKT1] -K(58,2) * [PDPK1_p \|AKT1];
R59	PDPK1_p \|AKT1	AKT1_p + PDPK1_p	PDPK1_p \|AKT1 → AKT1_p + PDPK1_p	V(59) = K(59,1) * [PDPK1_p \|AKT1];
R60	IGF1R + IGF1R_p	IGF1R_p \|IGF1R	IGF1R + IGF1R_p → IGF1R_p \|IGF1R	V(60) = K(60,1) * [IGF1R_p] * [IGF1R] -K(60,2) * [IGF1R_p \|IGF1R];
R61	IGF1R_p \|IGF1R	IGF1R_p + IGF1R_p	IGF1R_p \|IGF1R → IGF1R_p + IGF1R_p	V(61) = K(61,1) * [IGF1R_p \|IGF1R];
R62	FOXO1 + SGK1_p	SGK1_p \|FOXO1	FOXO1 + SGK1_p → SGK1_p \|FOXO1	V(62) = K(62,1) * [SGK1_p] * [FOXO1] -K(62,2) * [SGK1_p \|FOXO1];
R63	SGK1_p \|FOXO1	FOXO1_p + SGK1_p	SGK1_p \|FOXO1 → FOXO1_p + SGK1_p	V(63) = K(63,1) * [SGK1_p \|FOXO1];
R64	HIPK2 + HIPK2_p	HIPK2_p \|HIPK2	HIPK2 + HIPK2_p → HIPK2_p \|HIPK2	V(64) = K(64,1) * [HIPK2_p] * [HIPK2] -K(64,2) * [HIPK2_p \|HIPK2];
R65	HIPK2_p \|HIPK2	HIPK2_p + HIPK2_p	HIPK2_p \|HIPK2 → HIPK2_p + HIPK2_p	V(65) = K(65,1) * [HIPK2_p \|HIPK2];
R66	PDPK1 + PDPK1_p	PDPK1_p \|PDPK1	PDPK1 + PDPK1_p → PDPK1_p \|PDPK1	V(66) = K(66,1) * [PDPK1_p] * [PDPK1] -K(66,2) * [PDPK1_p \|PDPK1];
R67	PDPK1_p \|PDPK1	PDPK1_p + PDPK1_p	PDPK1_p \|PDPK1 → PDPK1_p + PDPK1_p	V(67) = K(67,1) * [PDPK1_p \|PDPK1];
R68	CDKN1B + SGK1_p	SGK1_p \|CDKN1B	CDKN1B + SGK1_p → SGK1_p \|CDKN1B	V(68) = K(68,1) * [SGK1_p] * [CDKN1B] -K(68,2) * [SGK1_p \|CDKN1B];
R69	SGK1_p \|CDKN1B	CDKN1B_p + SGK1_p	SGK1_p \|CDKN1B → CDKN1B_p + SGK1_p	V(69) = K(69,1) * [SGK1_p \|CDKN1B];
R70	FOXO1 + IKBKB_p	IKBKB_p \|FOXO1	FOXO1 + IKBKB_p → IKBKB_p \|FOXO1	V(70) = K(70,1) * [IKBKB_p] * [FOXO1] -K(70,2) * [IKBKB_p \|FOXO1];
R71	IKBKB_p \|FOXO1	FOXO1_p + IKBKB_p	IKBKB_p \|FOXO1 → FOXO1_p + IKBKB_p	V(71) = K(71,1) * [IKBKB_p \|FOXO1];
R72	FYN + FYN_p	FYN_p \|FYN	FYN + FYN_p → FYN_p \|FYN	V(72) = K(72,1) * [FYN_p] * [FYN] -K(72,2) * [FYN_p \|FYN];
R73	FYN_p \|FYN	FYN_p + FYN_p	FYN_p \|FYN → FYN_p + FYN_p	V(73) = K(73,1) * [FYN_p \|FYN];
R74	MAPK8_p + STAT6	MAPK8_p \|STAT6	MAPK8_p + STAT6 → MAPK8_p \|STAT6	V(74) = K(74,1) * [MAPK8_p] * [STAT6] -K(74,2) * [MAPK8_p \|STAT6];
R75	MAPK8_p \|STAT6	MAPK8_p + STAT6_p	MAPK8_p \|STAT6 → MAPK8_p + STAT6_p	V(75) = K(75,1) * [MAPK8_p \|STAT6];
R76	AKT1_p + VIM	AKT1_p \|VIM	AKT1_p + VIM → AKT1_p \|VIM	V(76) = K(76,1) * [AKT1_p] * [VIM] -K(76,2) * [AKT1_p \|VIM];
R77	AKT1_p \|VIM	AKT1_p + VIM_p	AKT1_p \|VIM → AKT1_p + VIM_p	V(77) = K(77,1) * [AKT1_p \|VIM];
R78	AXL + AXL_p	AXL_p \|AXL	AXL + AXL_p → AXL_p \|AXL	V(78) = K(78,1) * [AXL_p] * [AXL] -K(78,2) * [AXL_p \|AXL];
R79	AXL_p \|AXL	AXL_p + AXL_p	AXL_p \|AXL → AXL_p + AXL_p	V(79) = K(79,1) * [AXL_p \|AXL];
R80	CDK5_p + TP53	CDK5_p \|TP53	CDK5_p + TP53 → CDK5_p \|TP53	V(80) = K(80,1) * [CDK5_p] * [TP53] -K(80,2) * [CDK5_p \|TP53];
R81	CDK5_p \|TP53	CDK5_p + TP53_p	CDK5_p \|TP53 → CDK5_p + TP53_p	V(81) = K(81,1) * [CDK5_p \|TP53];
R82	CDKN1A + MAPK8_p	MAPK8_p \|CDKN1A	CDKN1A + MAPK8_p → MAPK8_p \|CDKN1A	V(82) = K(82,1) * [MAPK8_p] * [CDKN1A] -K(82,2) * [MAPK8_p \|CDKN1A];
R83	MAPK8_p \|CDKN1A	CDKN1A_p + MAPK8_p	MAPK8_p \|CDKN1A → CDKN1A_p + MAPK8_p	V(83) = K(83,1) * [MAPK8_p \|CDKN1A];
R84	AKT1S1 + AKT1_p	AKT1_p \|AKT1S1	AKT1S1 + AKT1_p → AKT1_p \|AKT1S1	V(84) = K(84,1) * [AKT1_p] * [AKT1S1] -K(84,2) * [AKT1_p \|AKT1S1];
R85	AKT1_p \|AKT1S1	AKT1S1_p + AKT1_p	AKT1_p \|AKT1S1 → AKT1S1_p + AKT1_p	V(85) = K(85,1) * [AKT1_p \|AKT1S1];
R86	JUN + MAPK8_p	MAPK8_p \|JUN	JUN + MAPK8_p → MAPK8_p \|JUN	V(86) = K(86,1) * [MAPK8_p] * [JUN] -K(86,2) * [MAPK8_p \|JUN];
R87	MAPK8_p \|JUN	JUN_p + MAPK8_p	MAPK8_p \|JUN → JUN_p + MAPK8_p	V(87) = K(87,1) * [MAPK8_p \|JUN];
R88	JAK1_p + STAT3	JAK1_p \|STAT3	JAK1_p + STAT3 → JAK1_p \|STAT3	V(88) = K(88,1) * [JAK1_p] * [STAT3] -K(88,2) * [JAK1_p \|STAT3];
R89	JAK1_p \|STAT3	JAK1_p + STAT3_p	JAK1_p \|STAT3 → JAK1_p + STAT3_p	V(89) = K(89,1) * [JAK1_p \|STAT3];
R90	IGF1R_p + PDPK1	IGF1R_p \|PDPK1	IGF1R_p + PDPK1 → IGF1R_p \|PDPK1	V(90) = K(90,1) * [IGF1R_p] * [PDPK1] -K(90,2) * [IGF1R_p \|PDPK1];
R91	IGF1R_p \|PDPK1	IGF1R_p + PDPK1_p	IGF1R_p \|PDPK1 → IGF1R_p + PDPK1_p	V(91) = K(91,1) * [IGF1R_p \|PDPK1];
R92	JAK2_p + STAT6	JAK2_p \|STAT6	JAK2_p + STAT6 → JAK2_p \|STAT6	V(92) = K(92,1) * [JAK2_p] * [STAT6] -K(92,2) * [JAK2_p \|STAT6];
R93	JAK2_p \|STAT6	JAK2_p + STAT6_p	JAK2_p \|STAT6 → JAK2_p + STAT6_p	V(93) = K(93,1) * [JAK2_p \|STAT6];
R94	FOXO1 + PKN1_p	PKN1_p \|FOXO1	FOXO1 + PKN1_p → PKN1_p \|FOXO1	V(94) = K(94,1) * [PKN1_p] * [FOXO1] -K(94,2) * [PKN1_p \|FOXO1];
R95	PKN1_p \|FOXO1	FOXO1_p + PKN1_p	PKN1_p \|FOXO1 → FOXO1_p + PKN1_p	V(95) = K(95,1) * [PKN1_p \|FOXO1];
R96	MAPK8_p + SP1	MAPK8_p \|SP1	MAPK8_p + SP1 → MAPK8_p \|SP1	V(96) = K(96,1) * [MAPK8_p] * [SP1] -K(96,2) * [MAPK8_p \|SP1];
R97	MAPK8_p \|SP1	MAPK8_p + SP1_p	MAPK8_p \|SP1 → MAPK8_p + SP1_p	V(97) = K(97,1) * [MAPK8_p \|SP1];
R98	PLK2 + TP53	PLK2 \|TP53	PLK2 + TP53 → PLK2 \|TP53	V(98) = K(98,1) * [PLK2] * [TP53] -K(98,2) * [PLK2 \|TP53];
R99	PLK2 \|TP53	PLK2 + TP53_p	PLK2 \|TP53 → PLK2 + TP53_p	V(99) = K(99,1) * [PLK2 \|TP53];
R100	JAK1_p + STAT6	JAK1_p \|STAT6	JAK1_p + STAT6 → JAK1_p \|STAT6	V(100) = K(100,1) * [JAK1_p] * [STAT6] -K(100,2) * [JAK1_p \|STAT6];
R101	JAK1_p \|STAT6	JAK1_p + STAT6_p	JAK1_p \|STAT6 → JAK1_p + STAT6_p	V(101) = K(101,1) * [JAK1_p \|STAT6];
R102	IGF1R_p + IRS2	IGF1R_p \|IRS2	IGF1R_p + IRS2 → IGF1R_p \|IRS2	V(102) = K(102,1) * [IGF1R_p] * [IRS2] -K(102,2) * [IGF1R_p \|IRS2];
R103	IGF1R_p \|IRS2	IGF1R_p + IRS2_p	IGF1R_p \|IRS2 → IGF1R_p + IRS2_p	V(103) = K(103,1) * [IGF1R_p \|IRS2];
R104	CDKN1B + JAK2_p	JAK2_p \|CDKN1B	CDKN1B + JAK2_p → JAK2_p \|CDKN1B	V(104) = K(104,1) * [JAK2_p] * [CDKN1B] -K(104,2) * [JAK2_p \|CDKN1B];
R105	JAK2_p \|CDKN1B	CDKN1B_p + JAK2_p	JAK2_p \|CDKN1B → CDKN1B_p + JAK2_p	V(105) = K(105,1) * [JAK2_p \|CDKN1B];
R106	HIPK2_p + MECP2	HIPK2_p \|MECP2	HIPK2_p + MECP2 → HIPK2_p \|MECP2	V(106) = K(106,1) * [HIPK2_p] * [MECP2] -K(106,2) * [HIPK2_p \|MECP2];
R107	HIPK2_p \|MECP2	HIPK2_p + MECP2_p	HIPK2_p \|MECP2 → HIPK2_p + MECP2_p	V(107) = K(107,1) * [HIPK2_p \|MECP2];
R108	AKT1_p + CTNNB1	AKT1_p \|CTNNB1	AKT1_p + CTNNB1 → AKT1_p \|CTNNB1	V(108) = K(108,1) * [AKT1_p] * [CTNNB1] -K(108,2) * [AKT1_p \|CTNNB1];
R109	AKT1_p \|CTNNB1	AKT1_p + CTNNB1_p	AKT1_p \|CTNNB1 → AKT1_p + CTNNB1_p	V(109) = K(109,1) * [AKT1_p \|CTNNB1];
R110	JUNB + MAPK8_p	MAPK8_p \|JUNB	JUNB + MAPK8_p → MAPK8_p \|JUNB	V(110) = K(110,1) * [MAPK8_p] * [JUNB] -K(110,2) * [MAPK8_p \|JUNB];
R111	MAPK8_p \|JUNB	JUNB_p + MAPK8_p	MAPK8_p \|JUNB → JUNB_p + MAPK8_p	V(111) = K(111,1) * [MAPK8_p \|JUNB];
R112	CDK5_p + PARP1	CDK5_p \|PARP1	CDK5_p + PARP1 → CDK5_p \|PARP1	V(112) = K(112,1) * [CDK5_p] * [PARP1] -K(112,2) * [CDK5_p \|PARP1];
R113	CDK5_p \|PARP1	CDK5_p + PARP1_p	CDK5_p \|PARP1 → CDK5_p + PARP1_p	V(113) = K(113,1) * [CDK5_p \|PARP1];
R114	LYN + LYN_p	LYN_p \|LYN	LYN + LYN_p → LYN_p \|LYN	V(114) = K(114,1) * [LYN_p] * [LYN] -K(114,2) * [LYN_p \|LYN];
R115	LYN_p \|LYN	LYN_p + LYN_p	LYN_p \|LYN → LYN_p + LYN_p	V(115) = K(115,1) * [LYN_p \|LYN];
R116	AKT1_p + MAPKAP1	AKT1_p \|MAPKAP1	AKT1_p + MAPKAP1 → AKT1_p \|MAPKAP1	V(116) = K(116,1) * [AKT1_p] * [MAPKAP1] -K(116,2) * [AKT1_p \|MAPKAP1];
R117	AKT1_p \|MAPKAP1	AKT1_p + MAPKAP1_p	AKT1_p \|MAPKAP1 → AKT1_p + MAPKAP1_p	V(117) = K(117,1) * [AKT1_p \|MAPKAP1];
R118	FYN_p + PTPRJ	FYN_p \|PTPRJ	FYN_p + PTPRJ → FYN_p \|PTPRJ	V(118) = K(118,1) * [FYN_p] * [PTPRJ] -K(118,2) * [FYN_p \|PTPRJ];
R119	FYN_p \|PTPRJ	FYN_p + PTPRJ_p	FYN_p \|PTPRJ → FYN_p + PTPRJ_p	V(119) = K(119,1) * [FYN_p \|PTPRJ];
R120	AKT1_p + PARK7	AKT1_p \|PARK7	AKT1_p + PARK7 → AKT1_p \|PARK7	V(120) = K(120,1) * [AKT1_p] * [PARK7] -K(120,2) * [AKT1_p \|PARK7];
R121	AKT1_p \|PARK7	AKT1_p + PARK7_p	AKT1_p \|PARK7 → AKT1_p + PARK7_p	V(121) = K(121,1) * [AKT1_p \|PARK7];
R122	SGK1_p + SP1	SGK1_p \|SP1	SGK1_p + SP1 → SGK1_p \|SP1	V(122) = K(122,1) * [SGK1_p] * [SP1] -K(122,2) * [SGK1_p \|SP1];
R123	SGK1_p \|SP1	SGK1_p + SP1_p	SGK1_p \|SP1 → SGK1_p + SP1_p	V(123) = K(123,1) * [SGK1_p \|SP1];
R124	PDPK1_p + PKN1	PDPK1_p \|PKN1	PDPK1_p + PKN1 → PDPK1_p \|PKN1	V(124) = K(124,1) * [PDPK1_p] * [PKN1] -K(124,2) * [PDPK1_p \|PKN1];
R125	PDPK1_p \|PKN1	PDPK1_p + PKN1_p	PDPK1_p \|PKN1 → PDPK1_p + PKN1_p	V(125) = K(125,1) * [PDPK1_p \|PKN1];
R126	INSR_p + IRS2	INSR_p \|IRS2	INSR_p + IRS2 → INSR_p \|IRS2	V(126) = K(126,1) * [INSR_p] * [IRS2] -K(126,2) * [INSR_p \|IRS2];
R127	INSR_p \|IRS2	INSR_p + IRS2_p	INSR_p \|IRS2 → INSR_p + IRS2_p	V(127) = K(127,1) * [INSR_p \|IRS2];
R128	GHR + JAK2_p	JAK2_p \|GHR	GHR + JAK2_p → JAK2_p \|GHR	V(128) = K(128,1) * [JAK2_p] * [GHR] -K(128,2) * [JAK2_p \|GHR];
R129	JAK2_p \|GHR	GHR_p + JAK2_p	JAK2_p \|GHR → GHR_p + JAK2_p	V(129) = K(129,1) * [JAK2_p \|GHR];
R130	CDK5_p + NOTCH1	CDK5_p \|NOTCH1	CDK5_p + NOTCH1 → CDK5_p \|NOTCH1	V(130) = K(130,1) * [CDK5_p] * [NOTCH1] -K(130,2) * [CDK5_p \|NOTCH1];
R131	CDK5_p \|NOTCH1	CDK5_p + NOTCH1_p	CDK5_p \|NOTCH1 → CDK5_p + NOTCH1_p	V(131) = K(131,1) * [CDK5_p \|NOTCH1];
R132	CDK5_p + CREB1	CDK5_p \|CREB1	CDK5_p + CREB1 → CDK5_p \|CREB1	V(132) = K(132,1) * [CDK5_p] * [CREB1] -K(132,2) * [CDK5_p \|CREB1];
R133	CDK5_p \|CREB1	CDK5_p + CREB1_p	CDK5_p \|CREB1 → CDK5_p + CREB1_p	V(133) = K(133,1) * [CDK5_p \|CREB1];
R134	JAK2_p + LEPR	JAK2_p \|LEPR	JAK2_p + LEPR → JAK2_p \|LEPR	V(134) = K(134,1) * [JAK2_p] * [LEPR] -K(134,2) * [JAK2_p \|LEPR];
R135	JAK2_p \|LEPR	JAK2_p + LEPR_p	JAK2_p \|LEPR → JAK2_p + LEPR_p	V(135) = K(135,1) * [JAK2_p \|LEPR];
R136	CDK5_p + PIK3C3	CDK5_p \|PIK3C3	CDK5_p + PIK3C3 → CDK5_p \|PIK3C3	V(136) = K(136,1) * [CDK5_p] * [PIK3C3] -K(136,2) * [CDK5_p \|PIK3C3];
R137	CDK5_p \|PIK3C3	CDK5_p + PIK3C3_p	CDK5_p \|PIK3C3 → CDK5_p + PIK3C3_p	V(137) = K(137,1) * [CDK5_p \|PIK3C3];
R138	AKT1 + AKT1_p	AKT1_p \|AKT1	AKT1 + AKT1_p → AKT1_p \|AKT1	V(138) = K(138,1) * [AKT1_p] * [AKT1] -K(138,2) * [AKT1_p \|AKT1];
R139	AKT1_p \|AKT1	AKT1_p + AKT1_p	AKT1_p \|AKT1 → AKT1_p + AKT1_p	V(139) = K(139,1) * [AKT1_p \|AKT1];
R140	INSR_p + PTPN6	INSR_p \|PTPN6	INSR_p + PTPN6 → INSR_p \|PTPN6	V(140) = K(140,1) * [INSR_p] * [PTPN6] -K(140,2) * [INSR_p \|PTPN6];
R141	INSR_p \|PTPN6	INSR_p + PTPN6_p	INSR_p \|PTPN6 → INSR_p + PTPN6_p	V(141) = K(141,1) * [INSR_p \|PTPN6];
R142	PINK1 + TP53	PINK1 \|TP53	PINK1 + TP53 → PINK1 \|TP53	V(142) = K(142,1) * [PINK1] * [TP53] -K(142,2) * [PINK1 \|TP53];
R143	PINK1 \|TP53	PINK1 + TP53_p	PINK1 \|TP53 → PINK1 + TP53_p	V(143) = K(143,1) * [PINK1 \|TP53];
R144	JAK2_p + STAT3	JAK2_p \|STAT3	JAK2_p + STAT3 → JAK2_p \|STAT3	V(144) = K(144,1) * [JAK2_p] * [STAT3] -K(144,2) * [JAK2_p \|STAT3];
R145	JAK2_p \|STAT3	JAK2_p + STAT3_p	JAK2_p \|STAT3 → JAK2_p + STAT3_p	V(145) = K(145,1) * [JAK2_p \|STAT3];
R146	INSR_p + PTEN	INSR_p \|PTEN	INSR_p + PTEN → INSR_p \|PTEN	V(146) = K(146,1) * [INSR_p] * [PTEN] -K(146,2) * [INSR_p \|PTEN];
R147	INSR_p \|PTEN	INSR_p + PTEN_p	INSR_p \|PTEN → INSR_p + PTEN_p	V(147) = K(147,1) * [INSR_p \|PTEN];
R148	INSR_p + PIK3R1	INSR_p \|PIK3R1	INSR_p + PIK3R1 → INSR_p \|PIK3R1	V(148) = K(148,1) * [INSR_p] * [PIK3R1] -K(148,2) * [INSR_p \|PIK3R1];
R149	INSR_p \|PIK3R1	INSR_p + PIK3R1_p	INSR_p \|PIK3R1 → INSR_p + PIK3R1_p	V(149) = K(149,1) * [INSR_p \|PIK3R1];
R150	MAPK8_p + STAT3	MAPK8_p \|STAT3	MAPK8_p + STAT3 → MAPK8_p \|STAT3	V(150) = K(150,1) * [MAPK8_p] * [STAT3] -K(150,2) * [MAPK8_p \|STAT3];
R151	MAPK8_p \|STAT3	MAPK8_p + STAT3_p	MAPK8_p \|STAT3 → MAPK8_p + STAT3_p	V(151) = K(151,1) * [MAPK8_p \|STAT3];
R152	GLO1 + LYN_p	LYN_p \|GLO1	GLO1 + LYN_p → LYN_p \|GLO1	V(152) = K(152,1) * [LYN_p] * [GLO1] -K(152,2) * [LYN_p \|GLO1];
R153	LYN_p \|GLO1	GLO1_p + LYN_p	LYN_p \|GLO1 → GLO1_p + LYN_p	V(153) = K(153,1) * [LYN_p \|GLO1];
R154	CDK5_p + STAT3	CDK5_p \|STAT3	CDK5_p + STAT3 → CDK5_p \|STAT3	V(154) = K(154,1) * [CDK5_p] * [STAT3] -K(154,2) * [CDK5_p \|STAT3];
R155	CDK5_p \|STAT3	CDK5_p + STAT3_p	CDK5_p \|STAT3 → CDK5_p + STAT3_p	V(155) = K(155,1) * [CDK5_p \|STAT3];
R156	AKT1_p + CREB1	AKT1_p \|CREB1	AKT1_p + CREB1 → AKT1_p \|CREB1	V(156) = K(156,1) * [AKT1_p] * [CREB1] -K(156,2) * [AKT1_p \|CREB1];
R157	AKT1_p \|CREB1	AKT1_p + CREB1_p	AKT1_p \|CREB1 → AKT1_p + CREB1_p	V(157) = K(157,1) * [AKT1_p \|CREB1];
R158	MFN2 + PINK1	PINK1 \|MFN2	MFN2 + PINK1 → PINK1 \|MFN2	V(158) = K(158,1) * [PINK1] * [MFN2] -K(158,2) * [PINK1 \|MFN2];
R159	PINK1 \|MFN2	MFN2_p + PINK1	PINK1 \|MFN2 → MFN2_p + PINK1	V(159) = K(159,1) * [PINK1 \|MFN2];
R160	MAPK8_p + STAT1	MAPK8_p \|STAT1	MAPK8_p + STAT1 → MAPK8_p \|STAT1	V(160) = K(160,1) * [MAPK8_p] * [STAT1] -K(160,2) * [MAPK8_p \|STAT1];
R161	MAPK8_p \|STAT1	MAPK8_p + STAT1_p	MAPK8_p \|STAT1 → MAPK8_p + STAT1_p	V(161) = K(161,1) * [MAPK8_p \|STAT1];
R162	CDK5 + FYN_p	FYN_p \|CDK5	CDK5 + FYN_p → FYN_p \|CDK5	V(162) = K(162,1) * [FYN_p] * [CDK5] -K(162,2) * [FYN_p \|CDK5];
R163	FYN_p \|CDK5	CDK5_p + FYN_p	FYN_p \|CDK5 → CDK5_p + FYN_p	V(163) = K(163,1) * [FYN_p \|CDK5];
R164	CDKN1B + LYN_p	LYN_p \|CDKN1B	CDKN1B + LYN_p → LYN_p \|CDKN1B	V(164) = K(164,1) * [LYN_p] * [CDKN1B] -K(164,2) * [LYN_p \|CDKN1B];
R165	LYN_p \|CDKN1B	CDKN1B_p + LYN_p	LYN_p \|CDKN1B → CDKN1B_p + LYN_p	V(165) = K(165,1) * [LYN_p \|CDKN1B];
R166	IKBKB_p + TP53	IKBKB_p \|TP53	IKBKB_p + TP53 → IKBKB_p \|TP53	V(166) = K(166,1) * [IKBKB_p] * [TP53] -K(166,2) * [IKBKB_p \|TP53];
R167	IKBKB_p \|TP53	IKBKB_p + TP53_p	IKBKB_p \|TP53 → IKBKB_p + TP53_p	V(167) = K(167,1) * [IKBKB_p \|TP53];
R168	MAPK8_p + NR4A1	MAPK8_p \|NR4A1	MAPK8_p + NR4A1 → MAPK8_p \|NR4A1	V(168) = K(168,1) * [MAPK8_p] * [NR4A1] -K(168,2) * [MAPK8_p \|NR4A1];
R169	MAPK8_p \|NR4A1	MAPK8_p + NR4A1_p	MAPK8_p \|NR4A1 → MAPK8_p + NR4A1_p	V(169) = K(169,1) * [MAPK8_p \|NR4A1];
R170	ATR + TP53	ATR \|TP53	ATR + TP53 → ATR \|TP53	V(170) = K(170,1) * [ATR] * [TP53] -K(170,2) * [ATR \|TP53];
R171	ATR \|TP53	ATR + TP53_p	ATR \|TP53 → ATR + TP53_p	V(171) = K(171,1) * [ATR \|TP53];
R172	ATR + CREB1	ATR \|CREB1	ATR + CREB1 → ATR \|CREB1	V(172) = K(172,1) * [ATR] * [CREB1] -K(172,2) * [ATR \|CREB1];
R173	ATR \|CREB1	ATR + CREB1_p	ATR \|CREB1 → ATR + CREB1_p	V(173) = K(173,1) * [ATR \|CREB1];
R174	CTNNB1 + FYN_p	FYN_p \|CTNNB1	CTNNB1 + FYN_p → FYN_p \|CTNNB1	V(174) = K(174,1) * [FYN_p] * [CTNNB1] -K(174,2) * [FYN_p \|CTNNB1];
R175	FYN_p \|CTNNB1	CTNNB1_p + FYN_p	FYN_p \|CTNNB1 → CTNNB1_p + FYN_p	V(175) = K(175,1) * [FYN_p \|CTNNB1];
R176	LYN_p + STAT3	LYN_p \|STAT3	LYN_p + STAT3 → LYN_p \|STAT3	V(176) = K(176,1) * [LYN_p] * [STAT3] -K(176,2) * [LYN_p \|STAT3];
R177	LYN_p \|STAT3	LYN_p + STAT3_p	LYN_p \|STAT3 → LYN_p + STAT3_p	V(177) = K(177,1) * [LYN_p \|STAT3];
R178	CDKN1B + HIPK2_p	HIPK2_p \|CDKN1B	CDKN1B + HIPK2_p → HIPK2_p \|CDKN1B	V(178) = K(178,1) * [HIPK2_p] * [CDKN1B] -K(178,2) * [HIPK2_p \|CDKN1B];
R179	HIPK2_p \|CDKN1B	CDKN1B_p + HIPK2_p	HIPK2_p \|CDKN1B → CDKN1B_p + HIPK2_p	V(179) = K(179,1) * [HIPK2_p \|CDKN1B];
R180	HIPK2_p + TP53	HIPK2_p \|TP53	HIPK2_p + TP53 → HIPK2_p \|TP53	V(180) = K(180,1) * [HIPK2_p] * [TP53] -K(180,2) * [HIPK2_p \|TP53];
R181	HIPK2_p \|TP53	HIPK2_p + TP53_p	HIPK2_p \|TP53 → HIPK2_p + TP53_p	V(181) = K(181,1) * [HIPK2_p \|TP53];
R182	SGK1_p + STAT1	SGK1_p \|STAT1	SGK1_p + STAT1 → SGK1_p \|STAT1	V(182) = K(182,1) * [SGK1_p] * [STAT1] -K(182,2) * [SGK1_p \|STAT1];
R183	SGK1_p \|STAT1	SGK1_p + STAT1_p	SGK1_p \|STAT1 → SGK1_p + STAT1_p	V(183) = K(183,1) * [SGK1_p \|STAT1];
R184	LEPR_p + STAT3	LEPR_p \|STAT3	LEPR_p + STAT3 → LEPR_p \|STAT3	V(184) = K(184,1) * [LEPR_p] * [STAT3] -K(184,2) * [LEPR_p \|STAT3];
R185	LEPR_p \|STAT3	LEPR_p + STAT3_p	LEPR_p \|STAT3 → LEPR_p + STAT3_p	V(185) = K(185,1) * [LEPR_p \|STAT3];
R186	CDK5_p + CDKN1B	CDK5_p \|CDKN1B	CDK5_p + CDKN1B → CDK5_p \|CDKN1B	V(186) = K(186,1) * [CDK5_p] * [CDKN1B] -K(186,2) * [CDK5_p \|CDKN1B];
R187	CDK5_p \|CDKN1B	CDK5_p + CDKN1B_p	CDK5_p \|CDKN1B → CDK5_p + CDKN1B_p	V(187) = K(187,1) * [CDK5_p \|CDKN1B];
R188	CDK5_p + VIM	CDK5_p \|VIM	CDK5_p + VIM → CDK5_p \|VIM	V(188) = K(188,1) * [CDK5_p] * [VIM] -K(188,2) * [CDK5_p \|VIM];
R189	CDK5_p \|VIM	CDK5_p + VIM_p	CDK5_p \|VIM → CDK5_p + VIM_p	V(189) = K(189,1) * [CDK5_p \|VIM];
R190	CDK5_p + HIF1A	CDK5_p \|HIF1A	CDK5_p + HIF1A → CDK5_p \|HIF1A	V(190) = K(190,1) * [CDK5_p] * [HIF1A] -K(190,2) * [CDK5_p \|HIF1A];
R191	CDK5_p \|HIF1A	CDK5_p + HIF1A_p	CDK5_p \|HIF1A → CDK5_p + HIF1A_p	V(191) = K(191,1) * [CDK5_p \|HIF1A];
R192	CDK5_p + CTNNB1	CDK5_p \|CTNNB1	CDK5_p + CTNNB1 → CDK5_p \|CTNNB1	V(192) = K(192,1) * [CDK5_p] * [CTNNB1] -K(192,2) * [CDK5_p \|CTNNB1];
R193	CDK5_p \|CTNNB1	CDK5_p + CTNNB1_p	CDK5_p \|CTNNB1 → CDK5_p + CTNNB1_p	V(193) = K(193,1) * [CDK5_p \|CTNNB1];
R194	CDK5_p + SIRT2	CDK5_p \|SIRT2	CDK5_p + SIRT2 → CDK5_p \|SIRT2	V(194) = K(194,1) * [CDK5_p] * [SIRT2] -K(194,2) * [CDK5_p \|SIRT2];
R195	CDK5_p \|SIRT2	CDK5_p + SIRT2_p	CDK5_p \|SIRT2 → CDK5_p + SIRT2_p	V(195) = K(195,1) * [CDK5_p \|SIRT2];
R196	EZH2 + JAK2_p	JAK2_p \|EZH2	EZH2 + JAK2_p → JAK2_p \|EZH2	V(196) = K(196,1) * [JAK2_p] * [EZH2] -K(196,2) * [JAK2_p \|EZH2];
R197	JAK2_p \|EZH2	EZH2_p + JAK2_p	JAK2_p \|EZH2 → EZH2_p + JAK2_p	V(197) = K(197,1) * [JAK2_p \|EZH2];
R198	PINK1 + PTEN	PINK1 \|PTEN	PINK1 + PTEN → PINK1 \|PTEN	V(198) = K(198,1) * [PINK1] * [PTEN] -K(198,2) * [PINK1 \|PTEN];
R199	PINK1 \|PTEN	PINK1 + PTEN_p	PINK1 \|PTEN → PINK1 + PTEN_p	V(199) = K(199,1) * [PINK1 \|PTEN];