Macula Densa_Parametric ODE Equations

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Reaction ID	Reactants	Products	Original Text	ODE Equations
R1	SMAD2_p + SMAD4_p	SIGNOR-C8	SMAD2_p + SMAD4_p → SIGNOR-C8	V(1) = K(1,1) * [SMAD2_p] * [SMAD4_p] -K(1,2) * [SIGNOR-C8];
R2	SMAD3_p + SMAD4_p	SIGNOR-C9	SMAD3_p + SMAD4_p → SIGNOR-C9	V(2) = K(2,1) * [SMAD4_p] * [SMAD3_p] -K(2,2) * [SIGNOR-C9];
R3	JUN_p + SMAD4_p	SIGNOR-C10	JUN_p + SMAD4_p → SIGNOR-C10	V(3) = K(3,1) * [SMAD4_p] * [JUN_p] -K(3,2) * [SIGNOR-C10];
R4	NR3C1_p + STAT5A_p	SIGNOR-C84	NR3C1_p + STAT5A_p → SIGNOR-C84	V(4) = K(4,1) * [NR3C1_p] * [STAT5A_p] -K(4,2) * [SIGNOR-C84];
R5	JUN_p + SMAD3_p	SIGNOR-C86	JUN_p + SMAD3_p → SIGNOR-C86	V(5) = K(5,1) * [JUN_p] * [SMAD3_p] -K(5,2) * [SIGNOR-C86];
R6	FOS_p + FOS_p + FOS_p + FOS_p + JUN_p + JUN_p + JUN_p + JUN_p	SIGNOR-C154	FOS_p + FOS_p + FOS_p + FOS_p + JUN_p + JUN_p + JUN_p + JUN_p → SIGNOR-C154	V(6) = K(6,1) * [FOS_p] * [JUN_p] * [JUN_p] * [FOS_p] * [JUN_p] * [FOS_p] * [FOS_p] * [JUN_p] -K(6,2) * [SIGNOR-C154];
R7	EP300 + MAPK1_p	MAPK1_p \|EP300	EP300 + MAPK1_p → MAPK1_p \|EP300	V(7) = K(7,1) * [MAPK1_p] * [EP300] -K(7,2) * [MAPK1_p \|EP300];
R8	MAPK1_p \|EP300	EP300_p + MAPK1_p	MAPK1_p \|EP300 → EP300_p + MAPK1_p	V(8) = K(8,1) * [MAPK1_p \|EP300];
R9	HIF1A + MAPK1_p	MAPK1_p \|HIF1A	HIF1A + MAPK1_p → MAPK1_p \|HIF1A	V(9) = K(9,1) * [MAPK1_p] * [HIF1A] -K(9,2) * [MAPK1_p \|HIF1A];
R10	MAPK1_p \|HIF1A	HIF1A_p + MAPK1_p	MAPK1_p \|HIF1A → HIF1A_p + MAPK1_p	V(10) = K(10,1) * [MAPK1_p \|HIF1A];
R11	MAPK1_p + NR3C1	MAPK1_p \|NR3C1	MAPK1_p + NR3C1 → MAPK1_p \|NR3C1	V(11) = K(11,1) * [MAPK1_p] * [NR3C1] -K(11,2) * [MAPK1_p \|NR3C1];
R12	MAPK1_p \|NR3C1	MAPK1_p + NR3C1_p	MAPK1_p \|NR3C1 → MAPK1_p + NR3C1_p	V(12) = K(12,1) * [MAPK1_p \|NR3C1];
R13	AKT1_p + FOXO1	AKT1_p \|FOXO1	AKT1_p + FOXO1 → AKT1_p \|FOXO1	V(13) = K(13,1) * [AKT1_p] * [FOXO1] -K(13,2) * [AKT1_p \|FOXO1];
R14	AKT1_p \|FOXO1	AKT1_p + FOXO1_p	AKT1_p \|FOXO1 → AKT1_p + FOXO1_p	V(14) = K(14,1) * [AKT1_p \|FOXO1];
R15	MAPK1_p + PRDX6	MAPK1_p \|PRDX6	MAPK1_p + PRDX6 → MAPK1_p \|PRDX6	V(15) = K(15,1) * [MAPK1_p] * [PRDX6] -K(15,2) * [MAPK1_p \|PRDX6];
R16	MAPK1_p \|PRDX6	MAPK1_p + PRDX6_p	MAPK1_p \|PRDX6 → MAPK1_p + PRDX6_p	V(16) = K(16,1) * [MAPK1_p \|PRDX6];
R17	PRKCZ_p + SP1	PRKCZ_p \|SP1	PRKCZ_p + SP1 → PRKCZ_p \|SP1	V(17) = K(17,1) * [PRKCZ_p] * [SP1] -K(17,2) * [PRKCZ_p \|SP1];
R18	PRKCZ_p \|SP1	PRKCZ_p + SP1_p	PRKCZ_p \|SP1 → PRKCZ_p + SP1_p	V(18) = K(18,1) * [PRKCZ_p \|SP1];
R19	MAPK1_p + RPS6KB1	MAPK1_p \|RPS6KB1	MAPK1_p + RPS6KB1 → MAPK1_p \|RPS6KB1	V(19) = K(19,1) * [MAPK1_p] * [RPS6KB1] -K(19,2) * [MAPK1_p \|RPS6KB1];
R20	MAPK1_p \|RPS6KB1	MAPK1_p + RPS6KB1_p	MAPK1_p \|RPS6KB1 → MAPK1_p + RPS6KB1_p	V(20) = K(20,1) * [MAPK1_p \|RPS6KB1];
R21	AKT1_p + PRKAA1	AKT1_p \|PRKAA1	AKT1_p + PRKAA1 → AKT1_p \|PRKAA1	V(21) = K(21,1) * [AKT1_p] * [PRKAA1] -K(21,2) * [AKT1_p \|PRKAA1];
R22	AKT1_p \|PRKAA1	AKT1_p + PRKAA1_p	AKT1_p \|PRKAA1 → AKT1_p + PRKAA1_p	V(22) = K(22,1) * [AKT1_p \|PRKAA1];
R23	EGFR + EGFR_p	EGFR_p \|EGFR	EGFR + EGFR_p → EGFR_p \|EGFR	V(23) = K(23,1) * [EGFR_p] * [EGFR] -K(23,2) * [EGFR_p \|EGFR];
R24	EGFR_p \|EGFR	EGFR_p + EGFR_p	EGFR_p \|EGFR → EGFR_p + EGFR_p	V(24) = K(24,1) * [EGFR_p \|EGFR];
R25	IKBKB + IKBKB_p	IKBKB_p \|IKBKB	IKBKB + IKBKB_p → IKBKB_p \|IKBKB	V(25) = K(25,1) * [IKBKB_p] * [IKBKB] -K(25,2) * [IKBKB_p \|IKBKB];
R26	IKBKB_p \|IKBKB	IKBKB_p + IKBKB_p	IKBKB_p \|IKBKB → IKBKB_p + IKBKB_p	V(26) = K(26,1) * [IKBKB_p \|IKBKB];
R27	CDKN1B + MAPK1_p	MAPK1_p \|CDKN1B	CDKN1B + MAPK1_p → MAPK1_p \|CDKN1B	V(27) = K(27,1) * [MAPK1_p] * [CDKN1B] -K(27,2) * [MAPK1_p \|CDKN1B];
R28	MAPK1_p \|CDKN1B	CDKN1B_p + MAPK1_p	MAPK1_p \|CDKN1B → CDKN1B_p + MAPK1_p	V(28) = K(28,1) * [MAPK1_p \|CDKN1B];
R29	MAPK1_p + SMAD4	MAPK1_p \|SMAD4	MAPK1_p + SMAD4 → MAPK1_p \|SMAD4	V(29) = K(29,1) * [MAPK1_p] * [SMAD4] -K(29,2) * [MAPK1_p \|SMAD4];
R30	MAPK1_p \|SMAD4	MAPK1_p + SMAD4_p	MAPK1_p \|SMAD4 → MAPK1_p + SMAD4_p	V(30) = K(30,1) * [MAPK1_p \|SMAD4];
R31	ESR1 + MAPK1_p	MAPK1_p \|ESR1	ESR1 + MAPK1_p → MAPK1_p \|ESR1	V(31) = K(31,1) * [MAPK1_p] * [ESR1] -K(31,2) * [MAPK1_p \|ESR1];
R32	MAPK1_p \|ESR1	ESR1_p + MAPK1_p	MAPK1_p \|ESR1 → ESR1_p + MAPK1_p	V(32) = K(32,1) * [MAPK1_p \|ESR1];
R33	MAPK1_p + STK11	MAPK1_p \|STK11	MAPK1_p + STK11 → MAPK1_p \|STK11	V(33) = K(33,1) * [MAPK1_p] * [STK11] -K(33,2) * [MAPK1_p \|STK11];
R34	MAPK1_p \|STK11	MAPK1_p + STK11_p	MAPK1_p \|STK11 → MAPK1_p + STK11_p	V(34) = K(34,1) * [MAPK1_p \|STK11];
R35	JUN + MAPK1_p	MAPK1_p \|JUN	JUN + MAPK1_p → MAPK1_p \|JUN	V(35) = K(35,1) * [MAPK1_p] * [JUN] -K(35,2) * [MAPK1_p \|JUN];
R36	MAPK1_p \|JUN	JUN_p + MAPK1_p	MAPK1_p \|JUN → JUN_p + MAPK1_p	V(36) = K(36,1) * [MAPK1_p \|JUN];
R37	AKT1_p + NR4A1	AKT1_p \|NR4A1	AKT1_p + NR4A1 → AKT1_p \|NR4A1	V(37) = K(37,1) * [AKT1_p] * [NR4A1] -K(37,2) * [AKT1_p \|NR4A1];
R38	AKT1_p \|NR4A1	AKT1_p + NR4A1_p	AKT1_p \|NR4A1 → AKT1_p + NR4A1_p	V(38) = K(38,1) * [AKT1_p \|NR4A1];
R39	FOS + MAPK1_p	MAPK1_p \|FOS	FOS + MAPK1_p → MAPK1_p \|FOS	V(39) = K(39,1) * [MAPK1_p] * [FOS] -K(39,2) * [MAPK1_p \|FOS];
R40	MAPK1_p \|FOS	FOS_p + MAPK1_p	MAPK1_p \|FOS → FOS_p + MAPK1_p	V(40) = K(40,1) * [MAPK1_p \|FOS];
R41	STK11 + STK11_p	STK11_p \|STK11	STK11 + STK11_p → STK11_p \|STK11	V(41) = K(41,1) * [STK11_p] * [STK11] -K(41,2) * [STK11_p \|STK11];
R42	STK11_p \|STK11	STK11_p + STK11_p	STK11_p \|STK11 → STK11_p + STK11_p	V(42) = K(42,1) * [STK11_p \|STK11];
R43	SRC + SRC_p	SRC_p \|SRC	SRC + SRC_p → SRC_p \|SRC	V(43) = K(43,1) * [SRC_p] * [SRC] -K(43,2) * [SRC_p \|SRC];
R44	SRC_p \|SRC	SRC_p + SRC_p	SRC_p \|SRC → SRC_p + SRC_p	V(44) = K(44,1) * [SRC_p \|SRC];
R45	SRC_p + TLR3	SRC_p \|TLR3	SRC_p + TLR3 → SRC_p \|TLR3	V(45) = K(45,1) * [SRC_p] * [TLR3] -K(45,2) * [SRC_p \|TLR3];
R46	SRC_p \|TLR3	SRC_p + TLR3_p	SRC_p \|TLR3 → SRC_p + TLR3_p	V(46) = K(46,1) * [SRC_p \|TLR3];
R47	MAPK1_p + SMAD2	MAPK1_p \|SMAD2	MAPK1_p + SMAD2 → MAPK1_p \|SMAD2	V(47) = K(47,1) * [MAPK1_p] * [SMAD2] -K(47,2) * [MAPK1_p \|SMAD2];
R48	MAPK1_p \|SMAD2	MAPK1_p + SMAD2_p	MAPK1_p \|SMAD2 → MAPK1_p + SMAD2_p	V(48) = K(48,1) * [MAPK1_p \|SMAD2];
R49	MAPK1_p + RORA	MAPK1_p \|RORA	MAPK1_p + RORA → MAPK1_p \|RORA	V(49) = K(49,1) * [MAPK1_p] * [RORA] -K(49,2) * [MAPK1_p \|RORA];
R50	MAPK1_p \|RORA	MAPK1_p + RORA_p	MAPK1_p \|RORA → MAPK1_p + RORA_p	V(50) = K(50,1) * [MAPK1_p \|RORA];
R51	PPARGC1A + PRKAA1_p	PRKAA1_p \|PPARGC1A	PPARGC1A + PRKAA1_p → PRKAA1_p \|PPARGC1A	V(51) = K(51,1) * [PRKAA1_p] * [PPARGC1A] -K(51,2) * [PRKAA1_p \|PPARGC1A];
R52	PRKAA1_p \|PPARGC1A	PPARGC1A_p + PRKAA1_p	PRKAA1_p \|PPARGC1A → PPARGC1A_p + PRKAA1_p	V(52) = K(52,1) * [PRKAA1_p \|PPARGC1A];
R53	INSR + INSR_p	INSR_p \|INSR	INSR + INSR_p → INSR_p \|INSR	V(53) = K(53,1) * [INSR_p] * [INSR] -K(53,2) * [INSR_p \|INSR];
R54	INSR_p \|INSR	INSR_p + INSR_p	INSR_p \|INSR → INSR_p + INSR_p	V(54) = K(54,1) * [INSR_p \|INSR];
R55	JAK1_p + STAT1	JAK1_p \|STAT1	JAK1_p + STAT1 → JAK1_p \|STAT1	V(55) = K(55,1) * [JAK1_p] * [STAT1] -K(55,2) * [JAK1_p \|STAT1];
R56	JAK1_p \|STAT1	JAK1_p + STAT1_p	JAK1_p \|STAT1 → JAK1_p + STAT1_p	V(56) = K(56,1) * [JAK1_p \|STAT1];
R57	DUSP1 + MAPK1_p	MAPK1_p \|DUSP1	DUSP1 + MAPK1_p → MAPK1_p \|DUSP1	V(57) = K(57,1) * [MAPK1_p] * [DUSP1] -K(57,2) * [MAPK1_p \|DUSP1];
R58	MAPK1_p \|DUSP1	DUSP1_p + MAPK1_p	MAPK1_p \|DUSP1 → DUSP1_p + MAPK1_p	V(58) = K(58,1) * [MAPK1_p \|DUSP1];
R59	AKT1_p + HSPB1	AKT1_p \|HSPB1	AKT1_p + HSPB1 → AKT1_p \|HSPB1	V(59) = K(59,1) * [AKT1_p] * [HSPB1] -K(59,2) * [AKT1_p \|HSPB1];
R60	AKT1_p \|HSPB1	AKT1_p + HSPB1_p	AKT1_p \|HSPB1 → AKT1_p + HSPB1_p	V(60) = K(60,1) * [AKT1_p \|HSPB1];
R61	HSPB1 + RPS6KB1_p	RPS6KB1_p \|HSPB1	HSPB1 + RPS6KB1_p → RPS6KB1_p \|HSPB1	V(61) = K(61,1) * [RPS6KB1_p] * [HSPB1] -K(61,2) * [RPS6KB1_p \|HSPB1];
R62	RPS6KB1_p \|HSPB1	HSPB1_p + RPS6KB1_p	RPS6KB1_p \|HSPB1 → HSPB1_p + RPS6KB1_p	V(62) = K(62,1) * [RPS6KB1_p \|HSPB1];
R63	AKT1_p + CDKN1A	AKT1_p \|CDKN1A	AKT1_p + CDKN1A → AKT1_p \|CDKN1A	V(63) = K(63,1) * [AKT1_p] * [CDKN1A] -K(63,2) * [AKT1_p \|CDKN1A];
R64	AKT1_p \|CDKN1A	AKT1_p + CDKN1A_p	AKT1_p \|CDKN1A → AKT1_p + CDKN1A_p	V(64) = K(64,1) * [AKT1_p \|CDKN1A];
R65	AKT1 + SRC_p	SRC_p \|AKT1	AKT1 + SRC_p → SRC_p \|AKT1	V(65) = K(65,1) * [SRC_p] * [AKT1] -K(65,2) * [SRC_p \|AKT1];
R66	SRC_p \|AKT1	AKT1_p + SRC_p	SRC_p \|AKT1 → AKT1_p + SRC_p	V(66) = K(66,1) * [SRC_p \|AKT1];
R67	EIF2AK3 + JAK1_p	JAK1_p \|EIF2AK3	EIF2AK3 + JAK1_p → JAK1_p \|EIF2AK3	V(67) = K(67,1) * [JAK1_p] * [EIF2AK3] -K(67,2) * [JAK1_p \|EIF2AK3];
R68	JAK1_p \|EIF2AK3	EIF2AK3_p + JAK1_p	JAK1_p \|EIF2AK3 → EIF2AK3_p + JAK1_p	V(68) = K(68,1) * [JAK1_p \|EIF2AK3];
R69	AKT1_p + ESR1	AKT1_p \|ESR1	AKT1_p + ESR1 → AKT1_p \|ESR1	V(69) = K(69,1) * [AKT1_p] * [ESR1] -K(69,2) * [AKT1_p \|ESR1];
R70	AKT1_p \|ESR1	AKT1_p + ESR1_p	AKT1_p \|ESR1 → AKT1_p + ESR1_p	V(70) = K(70,1) * [AKT1_p \|ESR1];
R71	MAPK1_p + RHOA	MAPK1_p \|RHOA	MAPK1_p + RHOA → MAPK1_p \|RHOA	V(71) = K(71,1) * [MAPK1_p] * [RHOA] -K(71,2) * [MAPK1_p \|RHOA];
R72	MAPK1_p \|RHOA	MAPK1_p + RHOA_p	MAPK1_p \|RHOA → MAPK1_p + RHOA_p	V(72) = K(72,1) * [MAPK1_p \|RHOA];
R73	CALM1 + EGFR_p	EGFR_p \|CALM1	CALM1 + EGFR_p → EGFR_p \|CALM1	V(73) = K(73,1) * [EGFR_p] * [CALM1] -K(73,2) * [EGFR_p \|CALM1];
R74	EGFR_p \|CALM1	CALM1_p + EGFR_p	EGFR_p \|CALM1 → CALM1_p + EGFR_p	V(74) = K(74,1) * [EGFR_p \|CALM1];
R75	AKT1_p + PPARGC1A	AKT1_p \|PPARGC1A	AKT1_p + PPARGC1A → AKT1_p \|PPARGC1A	V(75) = K(75,1) * [AKT1_p] * [PPARGC1A] -K(75,2) * [AKT1_p \|PPARGC1A];
R76	AKT1_p \|PPARGC1A	AKT1_p + PPARGC1A_p	AKT1_p \|PPARGC1A → AKT1_p + PPARGC1A_p	V(76) = K(76,1) * [AKT1_p \|PPARGC1A];
R77	FOXO1 + MAPK1_p	MAPK1_p \|FOXO1	FOXO1 + MAPK1_p → MAPK1_p \|FOXO1	V(77) = K(77,1) * [MAPK1_p] * [FOXO1] -K(77,2) * [MAPK1_p \|FOXO1];
R78	MAPK1_p \|FOXO1	FOXO1_p + MAPK1_p	MAPK1_p \|FOXO1 → FOXO1_p + MAPK1_p	V(78) = K(78,1) * [MAPK1_p \|FOXO1];
R79	EGFR + SRC_p	SRC_p \|EGFR	EGFR + SRC_p → SRC_p \|EGFR	V(79) = K(79,1) * [SRC_p] * [EGFR] -K(79,2) * [SRC_p \|EGFR];
R80	SRC_p \|EGFR	EGFR_p + SRC_p	SRC_p \|EGFR → EGFR_p + SRC_p	V(80) = K(80,1) * [SRC_p \|EGFR];
R81	SRC_p + STAT1	SRC_p \|STAT1	SRC_p + STAT1 → SRC_p \|STAT1	V(81) = K(81,1) * [SRC_p] * [STAT1] -K(81,2) * [SRC_p \|STAT1];
R82	SRC_p \|STAT1	SRC_p + STAT1_p	SRC_p \|STAT1 → SRC_p + STAT1_p	V(82) = K(82,1) * [SRC_p \|STAT1];
R83	MAPK1_p + SMAD3	MAPK1_p \|SMAD3	MAPK1_p + SMAD3 → MAPK1_p \|SMAD3	V(83) = K(83,1) * [MAPK1_p] * [SMAD3] -K(83,2) * [MAPK1_p \|SMAD3];
R84	MAPK1_p \|SMAD3	MAPK1_p + SMAD3_p	MAPK1_p \|SMAD3 → MAPK1_p + SMAD3_p	V(84) = K(84,1) * [MAPK1_p \|SMAD3];
R85	MAPK1_p + TFEB	MAPK1_p \|TFEB	MAPK1_p + TFEB → MAPK1_p \|TFEB	V(85) = K(85,1) * [MAPK1_p] * [TFEB] -K(85,2) * [MAPK1_p \|TFEB];
R86	MAPK1_p \|TFEB	MAPK1_p + TFEB_p	MAPK1_p \|TFEB → MAPK1_p + TFEB_p	V(86) = K(86,1) * [MAPK1_p \|TFEB];
R87	CALM1 + INSR_p	INSR_p \|CALM1	CALM1 + INSR_p → INSR_p \|CALM1	V(87) = K(87,1) * [INSR_p] * [CALM1] -K(87,2) * [INSR_p \|CALM1];
R88	INSR_p \|CALM1	CALM1_p + INSR_p	INSR_p \|CALM1 → CALM1_p + INSR_p	V(88) = K(88,1) * [INSR_p \|CALM1];
R89	ERN1 + ERN1_p	ERN1_p \|ERN1	ERN1 + ERN1_p → ERN1_p \|ERN1	V(89) = K(89,1) * [ERN1_p] * [ERN1] -K(89,2) * [ERN1_p \|ERN1];
R90	ERN1_p \|ERN1	ERN1_p + ERN1_p	ERN1_p \|ERN1 → ERN1_p + ERN1_p	V(90) = K(90,1) * [ERN1_p \|ERN1];
R91	SRC_p + TRAF6	SRC_p \|TRAF6	SRC_p + TRAF6 → SRC_p \|TRAF6	V(91) = K(91,1) * [SRC_p] * [TRAF6] -K(91,2) * [SRC_p \|TRAF6];
R92	SRC_p \|TRAF6	SRC_p + TRAF6_p	SRC_p \|TRAF6 → SRC_p + TRAF6_p	V(92) = K(92,1) * [SRC_p \|TRAF6];
R93	AKT1_p + CDKN1B	AKT1_p \|CDKN1B	AKT1_p + CDKN1B → AKT1_p \|CDKN1B	V(93) = K(93,1) * [AKT1_p] * [CDKN1B] -K(93,2) * [AKT1_p \|CDKN1B];
R94	AKT1_p \|CDKN1B	AKT1_p + CDKN1B_p	AKT1_p \|CDKN1B → AKT1_p + CDKN1B_p	V(94) = K(94,1) * [AKT1_p \|CDKN1B];
R95	BAX + PRKCZ_p	PRKCZ_p \|BAX	BAX + PRKCZ_p → PRKCZ_p \|BAX	V(95) = K(95,1) * [PRKCZ_p] * [BAX] -K(95,2) * [PRKCZ_p \|BAX];
R96	PRKCZ_p \|BAX	BAX_p + PRKCZ_p	PRKCZ_p \|BAX → BAX_p + PRKCZ_p	V(96) = K(96,1) * [PRKCZ_p \|BAX];
R97	PRKCZ_p + YAP1	PRKCZ_p \|YAP1	PRKCZ_p + YAP1 → PRKCZ_p \|YAP1	V(97) = K(97,1) * [PRKCZ_p] * [YAP1] -K(97,2) * [PRKCZ_p \|YAP1];
R98	PRKCZ_p \|YAP1	PRKCZ_p + YAP1_p	PRKCZ_p \|YAP1 → PRKCZ_p + YAP1_p	V(98) = K(98,1) * [PRKCZ_p \|YAP1];
R99	MAPK1_p + SIGNOR-C154	MAPK1_p \|SIGNOR-C154	MAPK1_p + SIGNOR-C154 → MAPK1_p \|SIGNOR-C154	V(99) = K(99,1) * [MAPK1_p] * [SIGNOR-C154] -K(99,2) * [MAPK1_p \|SIGNOR-C154];
R100	MAPK1_p \|SIGNOR-C154	MAPK1_p + SIGNOR-C154_p	MAPK1_p \|SIGNOR-C154 → MAPK1_p + SIGNOR-C154_p	V(100) = K(100,1) * [MAPK1_p \|SIGNOR-C154];
R101	MAPK1_p + PPARA	MAPK1_p \|PPARA	MAPK1_p + PPARA → MAPK1_p \|PPARA	V(101) = K(101,1) * [MAPK1_p] * [PPARA] -K(101,2) * [MAPK1_p \|PPARA];
R102	MAPK1_p \|PPARA	MAPK1_p + PPARA_p	MAPK1_p \|PPARA → MAPK1_p + PPARA_p	V(102) = K(102,1) * [MAPK1_p \|PPARA];
R103	PRKCZ_p + VIM	PRKCZ_p \|VIM	PRKCZ_p + VIM → PRKCZ_p \|VIM	V(103) = K(103,1) * [PRKCZ_p] * [VIM] -K(103,2) * [PRKCZ_p \|VIM];
R104	PRKCZ_p \|VIM	PRKCZ_p + VIM_p	PRKCZ_p \|VIM → PRKCZ_p + VIM_p	V(104) = K(104,1) * [PRKCZ_p \|VIM];
R105	PTEN + STK11_p	STK11_p \|PTEN	PTEN + STK11_p → STK11_p \|PTEN	V(105) = K(105,1) * [STK11_p] * [PTEN] -K(105,2) * [STK11_p \|PTEN];
R106	STK11_p \|PTEN	PTEN_p + STK11_p	STK11_p \|PTEN → PTEN_p + STK11_p	V(106) = K(106,1) * [STK11_p \|PTEN];
R107	FOXO1 + SGK1	SGK1 \|FOXO1	FOXO1 + SGK1 → SGK1 \|FOXO1	V(107) = K(107,1) * [SGK1] * [FOXO1] -K(107,2) * [SGK1 \|FOXO1];
R108	SGK1 \|FOXO1	FOXO1_p + SGK1	SGK1 \|FOXO1 → FOXO1_p + SGK1	V(108) = K(108,1) * [SGK1 \|FOXO1];
R109	CDKN1B + SGK1	SGK1 \|CDKN1B	CDKN1B + SGK1 → SGK1 \|CDKN1B	V(109) = K(109,1) * [SGK1] * [CDKN1B] -K(109,2) * [SGK1 \|CDKN1B];
R110	SGK1 \|CDKN1B	CDKN1B_p + SGK1	SGK1 \|CDKN1B → CDKN1B_p + SGK1	V(110) = K(110,1) * [SGK1 \|CDKN1B];
R111	AKT1_p + EP300	AKT1_p \|EP300	AKT1_p + EP300 → AKT1_p \|EP300	V(111) = K(111,1) * [AKT1_p] * [EP300] -K(111,2) * [AKT1_p \|EP300];
R112	AKT1_p \|EP300	AKT1_p + EP300_p	AKT1_p \|EP300 → AKT1_p + EP300_p	V(112) = K(112,1) * [AKT1_p \|EP300];
R113	FOXO1 + IKBKB_p	IKBKB_p \|FOXO1	FOXO1 + IKBKB_p → IKBKB_p \|FOXO1	V(113) = K(113,1) * [IKBKB_p] * [FOXO1] -K(113,2) * [IKBKB_p \|FOXO1];
R114	IKBKB_p \|FOXO1	FOXO1_p + IKBKB_p	IKBKB_p \|FOXO1 → FOXO1_p + IKBKB_p	V(114) = K(114,1) * [IKBKB_p \|FOXO1];
R115	EGFR + MAPK1_p	MAPK1_p \|EGFR	EGFR + MAPK1_p → MAPK1_p \|EGFR	V(115) = K(115,1) * [MAPK1_p] * [EGFR] -K(115,2) * [MAPK1_p \|EGFR];
R116	MAPK1_p \|EGFR	EGFR_p + MAPK1_p	MAPK1_p \|EGFR → EGFR_p + MAPK1_p	V(116) = K(116,1) * [MAPK1_p \|EGFR];
R117	PTEN + SRC_p	SRC_p \|PTEN	PTEN + SRC_p → SRC_p \|PTEN	V(117) = K(117,1) * [SRC_p] * [PTEN] -K(117,2) * [SRC_p \|PTEN];
R118	SRC_p \|PTEN	PTEN_p + SRC_p	SRC_p \|PTEN → PTEN_p + SRC_p	V(118) = K(118,1) * [SRC_p \|PTEN];
R119	EIF2AK3 + EIF2AK3_p	EIF2AK3_p \|EIF2AK3	EIF2AK3 + EIF2AK3_p → EIF2AK3_p \|EIF2AK3	V(119) = K(119,1) * [EIF2AK3_p] * [EIF2AK3] -K(119,2) * [EIF2AK3_p \|EIF2AK3];
R120	EIF2AK3_p \|EIF2AK3	EIF2AK3_p + EIF2AK3_p	EIF2AK3_p \|EIF2AK3 → EIF2AK3_p + EIF2AK3_p	V(120) = K(120,1) * [EIF2AK3_p \|EIF2AK3];
R121	ESR1 + RPS6KB1_p	RPS6KB1_p \|ESR1	ESR1 + RPS6KB1_p → RPS6KB1_p \|ESR1	V(121) = K(121,1) * [RPS6KB1_p] * [ESR1] -K(121,2) * [RPS6KB1_p \|ESR1];
R122	RPS6KB1_p \|ESR1	ESR1_p + RPS6KB1_p	RPS6KB1_p \|ESR1 → ESR1_p + RPS6KB1_p	V(122) = K(122,1) * [RPS6KB1_p \|ESR1];
R123	AKT1_p + VIM	AKT1_p \|VIM	AKT1_p + VIM → AKT1_p \|VIM	V(123) = K(123,1) * [AKT1_p] * [VIM] -K(123,2) * [AKT1_p \|VIM];
R124	AKT1_p \|VIM	AKT1_p + VIM_p	AKT1_p \|VIM → AKT1_p + VIM_p	V(124) = K(124,1) * [AKT1_p \|VIM];
R125	PRKCZ + PRKCZ_p	PRKCZ_p \|PRKCZ	PRKCZ + PRKCZ_p → PRKCZ_p \|PRKCZ	V(125) = K(125,1) * [PRKCZ_p] * [PRKCZ] -K(125,2) * [PRKCZ_p \|PRKCZ];
R126	PRKCZ_p \|PRKCZ	PRKCZ_p + PRKCZ_p	PRKCZ_p \|PRKCZ → PRKCZ_p + PRKCZ_p	V(126) = K(126,1) * [PRKCZ_p \|PRKCZ];
R127	DNMT1 + PRKAA1_p	PRKAA1_p \|DNMT1	DNMT1 + PRKAA1_p → PRKAA1_p \|DNMT1	V(127) = K(127,1) * [PRKAA1_p] * [DNMT1] -K(127,2) * [PRKAA1_p \|DNMT1];
R128	PRKAA1_p \|DNMT1	DNMT1_p + PRKAA1_p	PRKAA1_p \|DNMT1 → DNMT1_p + PRKAA1_p	V(128) = K(128,1) * [PRKAA1_p \|DNMT1];
R129	AKT1 + ILK_p	ILK_p \|AKT1	AKT1 + ILK_p → ILK_p \|AKT1	V(129) = K(129,1) * [ILK_p] * [AKT1] -K(129,2) * [ILK_p \|AKT1];
R130	ILK_p \|AKT1	AKT1_p + ILK_p	ILK_p \|AKT1 → AKT1_p + ILK_p	V(130) = K(130,1) * [ILK_p \|AKT1];
R131	MAPK1_p + SP1	MAPK1_p \|SP1	MAPK1_p + SP1 → MAPK1_p \|SP1	V(131) = K(131,1) * [MAPK1_p] * [SP1] -K(131,2) * [MAPK1_p \|SP1];
R132	MAPK1_p \|SP1	MAPK1_p + SP1_p	MAPK1_p \|SP1 → MAPK1_p + SP1_p	V(132) = K(132,1) * [MAPK1_p \|SP1];
R133	PRKCZ_p + STK11	PRKCZ_p \|STK11	PRKCZ_p + STK11 → PRKCZ_p \|STK11	V(133) = K(133,1) * [PRKCZ_p] * [STK11] -K(133,2) * [PRKCZ_p \|STK11];
R134	PRKCZ_p \|STK11	PRKCZ_p + STK11_p	PRKCZ_p \|STK11 → PRKCZ_p + STK11_p	V(134) = K(134,1) * [PRKCZ_p \|STK11];
R135	MAPK1_p + STAT5A	MAPK1_p \|STAT5A	MAPK1_p + STAT5A → MAPK1_p \|STAT5A	V(135) = K(135,1) * [MAPK1_p] * [STAT5A] -K(135,2) * [MAPK1_p \|STAT5A];
R136	MAPK1_p \|STAT5A	MAPK1_p + STAT5A_p	MAPK1_p \|STAT5A → MAPK1_p + STAT5A_p	V(136) = K(136,1) * [MAPK1_p \|STAT5A];
R137	PTPRJ + SRC_p	SRC_p \|PTPRJ	PTPRJ + SRC_p → SRC_p \|PTPRJ	V(137) = K(137,1) * [SRC_p] * [PTPRJ] -K(137,2) * [SRC_p \|PTPRJ];
R138	SRC_p \|PTPRJ	PTPRJ_p + SRC_p	SRC_p \|PTPRJ → PTPRJ_p + SRC_p	V(138) = K(138,1) * [SRC_p \|PTPRJ];
R139	CDKN1A + MAPK1_p	MAPK1_p \|CDKN1A	CDKN1A + MAPK1_p → MAPK1_p \|CDKN1A	V(139) = K(139,1) * [MAPK1_p] * [CDKN1A] -K(139,2) * [MAPK1_p \|CDKN1A];
R140	MAPK1_p \|CDKN1A	CDKN1A_p + MAPK1_p	MAPK1_p \|CDKN1A → CDKN1A_p + MAPK1_p	V(140) = K(140,1) * [MAPK1_p \|CDKN1A];
R141	FOXO1 + PRKAA1_p	PRKAA1_p \|FOXO1	FOXO1 + PRKAA1_p → PRKAA1_p \|FOXO1	V(141) = K(141,1) * [PRKAA1_p] * [FOXO1] -K(141,2) * [PRKAA1_p \|FOXO1];
R142	PRKAA1_p \|FOXO1	FOXO1_p + PRKAA1_p	PRKAA1_p \|FOXO1 → FOXO1_p + PRKAA1_p	V(142) = K(142,1) * [PRKAA1_p \|FOXO1];
R143	RAPGEF1 + SRC_p	SRC_p \|RAPGEF1	RAPGEF1 + SRC_p → SRC_p \|RAPGEF1	V(143) = K(143,1) * [SRC_p] * [RAPGEF1] -K(143,2) * [SRC_p \|RAPGEF1];
R144	SRC_p \|RAPGEF1	RAPGEF1_p + SRC_p	SRC_p \|RAPGEF1 → RAPGEF1_p + SRC_p	V(144) = K(144,1) * [SRC_p \|RAPGEF1];
R145	KRT19 + SRC_p	SRC_p \|KRT19	KRT19 + SRC_p → SRC_p \|KRT19	V(145) = K(145,1) * [SRC_p] * [KRT19] -K(145,2) * [SRC_p \|KRT19];
R146	SRC_p \|KRT19	KRT19_p + SRC_p	SRC_p \|KRT19 → KRT19_p + SRC_p	V(146) = K(146,1) * [SRC_p \|KRT19];
R147	AKT1_p + CASP9	AKT1_p \|CASP9	AKT1_p + CASP9 → AKT1_p \|CASP9	V(147) = K(147,1) * [AKT1_p] * [CASP9] -K(147,2) * [AKT1_p \|CASP9];
R148	AKT1_p \|CASP9	AKT1_p + CASP9_p	AKT1_p \|CASP9 → AKT1_p + CASP9_p	V(148) = K(148,1) * [AKT1_p \|CASP9];
R149	AKT1_p + NR3C1	AKT1_p \|NR3C1	AKT1_p + NR3C1 → AKT1_p \|NR3C1	V(149) = K(149,1) * [AKT1_p] * [NR3C1] -K(149,2) * [AKT1_p \|NR3C1];
R150	AKT1_p \|NR3C1	AKT1_p + NR3C1_p	AKT1_p \|NR3C1 → AKT1_p + NR3C1_p	V(150) = K(150,1) * [AKT1_p \|NR3C1];
R151	SMAD4 + STK11_p	STK11_p \|SMAD4	SMAD4 + STK11_p → STK11_p \|SMAD4	V(151) = K(151,1) * [STK11_p] * [SMAD4] -K(151,2) * [STK11_p \|SMAD4];
R152	STK11_p \|SMAD4	SMAD4_p + STK11_p	STK11_p \|SMAD4 → SMAD4_p + STK11_p	V(152) = K(152,1) * [STK11_p \|SMAD4];
R153	CASP9 + PRKCZ_p	PRKCZ_p \|CASP9	CASP9 + PRKCZ_p → PRKCZ_p \|CASP9	V(153) = K(153,1) * [PRKCZ_p] * [CASP9] -K(153,2) * [PRKCZ_p \|CASP9];
R154	PRKCZ_p \|CASP9	CASP9_p + PRKCZ_p	PRKCZ_p \|CASP9 → CASP9_p + PRKCZ_p	V(154) = K(154,1) * [PRKCZ_p \|CASP9];
R155	CASP9 + MAPK1_p	MAPK1_p \|CASP9	CASP9 + MAPK1_p → MAPK1_p \|CASP9	V(155) = K(155,1) * [MAPK1_p] * [CASP9] -K(155,2) * [MAPK1_p \|CASP9];
R156	MAPK1_p \|CASP9	CASP9_p + MAPK1_p	MAPK1_p \|CASP9 → CASP9_p + MAPK1_p	V(156) = K(156,1) * [MAPK1_p \|CASP9];
R157	IKBKB + SRC_p	SRC_p \|IKBKB	IKBKB + SRC_p → SRC_p \|IKBKB	V(157) = K(157,1) * [SRC_p] * [IKBKB] -K(157,2) * [SRC_p \|IKBKB];
R158	SRC_p \|IKBKB	IKBKB_p + SRC_p	SRC_p \|IKBKB → IKBKB_p + SRC_p	V(158) = K(158,1) * [SRC_p \|IKBKB];
R159	RICTOR + RPS6KB1_p	RPS6KB1_p \|RICTOR	RICTOR + RPS6KB1_p → RPS6KB1_p \|RICTOR	V(159) = K(159,1) * [RPS6KB1_p] * [RICTOR] -K(159,2) * [RPS6KB1_p \|RICTOR];
R160	RPS6KB1_p \|RICTOR	RICTOR_p + RPS6KB1_p	RPS6KB1_p \|RICTOR → RICTOR_p + RPS6KB1_p	V(160) = K(160,1) * [RPS6KB1_p \|RICTOR];
R161	JAK1_p + STAT6	JAK1_p \|STAT6	JAK1_p + STAT6 → JAK1_p \|STAT6	V(161) = K(161,1) * [JAK1_p] * [STAT6] -K(161,2) * [JAK1_p \|STAT6];
R162	JAK1_p \|STAT6	JAK1_p + STAT6_p	JAK1_p \|STAT6 → JAK1_p + STAT6_p	V(162) = K(162,1) * [JAK1_p \|STAT6];
R163	AKT1_p + YAP1	AKT1_p \|YAP1	AKT1_p + YAP1 → AKT1_p \|YAP1	V(163) = K(163,1) * [AKT1_p] * [YAP1] -K(163,2) * [AKT1_p \|YAP1];
R164	AKT1_p \|YAP1	AKT1_p + YAP1_p	AKT1_p \|YAP1 → AKT1_p + YAP1_p	V(164) = K(164,1) * [AKT1_p \|YAP1];
R165	AKT1_p + DNMT1	AKT1_p \|DNMT1	AKT1_p + DNMT1 → AKT1_p \|DNMT1	V(165) = K(165,1) * [AKT1_p] * [DNMT1] -K(165,2) * [AKT1_p \|DNMT1];
R166	AKT1_p \|DNMT1	AKT1_p + DNMT1_p	AKT1_p \|DNMT1 → AKT1_p + DNMT1_p	V(166) = K(166,1) * [AKT1_p \|DNMT1];
R167	EP300 + PRKAA1_p	PRKAA1_p \|EP300	EP300 + PRKAA1_p → PRKAA1_p \|EP300	V(167) = K(167,1) * [PRKAA1_p] * [EP300] -K(167,2) * [PRKAA1_p \|EP300];
R168	PRKAA1_p \|EP300	EP300_p + PRKAA1_p	PRKAA1_p \|EP300 → EP300_p + PRKAA1_p	V(168) = K(168,1) * [PRKAA1_p \|EP300];
R169	AKT1_p + CTNNB1	AKT1_p \|CTNNB1	AKT1_p + CTNNB1 → AKT1_p \|CTNNB1	V(169) = K(169,1) * [AKT1_p] * [CTNNB1] -K(169,2) * [AKT1_p \|CTNNB1];
R170	AKT1_p \|CTNNB1	AKT1_p + CTNNB1_p	AKT1_p \|CTNNB1 → AKT1_p + CTNNB1_p	V(170) = K(170,1) * [AKT1_p \|CTNNB1];
R171	MAP4K2 + MAP4K2_p	MAP4K2_p \|MAP4K2	MAP4K2 + MAP4K2_p → MAP4K2_p \|MAP4K2	V(171) = K(171,1) * [MAP4K2_p] * [MAP4K2] -K(171,2) * [MAP4K2_p \|MAP4K2];
R172	MAP4K2_p \|MAP4K2	MAP4K2_p + MAP4K2_p	MAP4K2_p \|MAP4K2 → MAP4K2_p + MAP4K2_p	V(172) = K(172,1) * [MAP4K2_p \|MAP4K2];
R173	STK11_p + YAP1	STK11_p \|YAP1	STK11_p + YAP1 → STK11_p \|YAP1	V(173) = K(173,1) * [STK11_p] * [YAP1] -K(173,2) * [STK11_p \|YAP1];
R174	STK11_p \|YAP1	STK11_p + YAP1_p	STK11_p \|YAP1 → STK11_p + YAP1_p	V(174) = K(174,1) * [STK11_p \|YAP1];
R175	MAPK1 + MAPK1_p	MAPK1_p \|MAPK1	MAPK1 + MAPK1_p → MAPK1_p \|MAPK1	V(175) = K(175,1) * [MAPK1_p] * [MAPK1] -K(175,2) * [MAPK1_p \|MAPK1];
R176	MAPK1_p \|MAPK1	MAPK1_p + MAPK1_p	MAPK1_p \|MAPK1 → MAPK1_p + MAPK1_p	V(176) = K(176,1) * [MAPK1_p \|MAPK1];
R177	MAPK1_p + RRAS	MAPK1_p \|RRAS	MAPK1_p + RRAS → MAPK1_p \|RRAS	V(177) = K(177,1) * [MAPK1_p] * [RRAS] -K(177,2) * [MAPK1_p \|RRAS];
R178	MAPK1_p \|RRAS	MAPK1_p + RRAS_p	MAPK1_p \|RRAS → MAPK1_p + RRAS_p	V(178) = K(178,1) * [MAPK1_p \|RRAS];
R179	CDH1 + SRC_p	SRC_p \|CDH1	CDH1 + SRC_p → SRC_p \|CDH1	V(179) = K(179,1) * [SRC_p] * [CDH1] -K(179,2) * [SRC_p \|CDH1];
R180	SRC_p \|CDH1	CDH1_p + SRC_p	SRC_p \|CDH1 → CDH1_p + SRC_p	V(180) = K(180,1) * [SRC_p \|CDH1];
R181	MAPK1_p + ZFP36	MAPK1_p \|ZFP36	MAPK1_p + ZFP36 → MAPK1_p \|ZFP36	V(181) = K(181,1) * [MAPK1_p] * [ZFP36] -K(181,2) * [MAPK1_p \|ZFP36];
R182	MAPK1_p \|ZFP36	MAPK1_p + ZFP36_p	MAPK1_p \|ZFP36 → MAPK1_p + ZFP36_p	V(182) = K(182,1) * [MAPK1_p \|ZFP36];
R183	AKT1_p + MAPKAP1	AKT1_p \|MAPKAP1	AKT1_p + MAPKAP1 → AKT1_p \|MAPKAP1	V(183) = K(183,1) * [AKT1_p] * [MAPKAP1] -K(183,2) * [AKT1_p \|MAPKAP1];
R184	AKT1_p \|MAPKAP1	AKT1_p + MAPKAP1_p	AKT1_p \|MAPKAP1 → AKT1_p + MAPKAP1_p	V(184) = K(184,1) * [AKT1_p \|MAPKAP1];
R185	MAPK1_p + RCAN1	MAPK1_p \|RCAN1	MAPK1_p + RCAN1 → MAPK1_p \|RCAN1	V(185) = K(185,1) * [MAPK1_p] * [RCAN1] -K(185,2) * [MAPK1_p \|RCAN1];
R186	MAPK1_p \|RCAN1	MAPK1_p + RCAN1_p	MAPK1_p \|RCAN1 → MAPK1_p + RCAN1_p	V(186) = K(186,1) * [MAPK1_p \|RCAN1];
R187	EGFR_p + ESR1	EGFR_p \|ESR1	EGFR_p + ESR1 → EGFR_p \|ESR1	V(187) = K(187,1) * [EGFR_p] * [ESR1] -K(187,2) * [EGFR_p \|ESR1];
R188	EGFR_p \|ESR1	EGFR_p + ESR1_p	EGFR_p \|ESR1 → EGFR_p + ESR1_p	V(188) = K(188,1) * [EGFR_p \|ESR1];
R189	CTNNB1 + PRKCZ_p	PRKCZ_p \|CTNNB1	CTNNB1 + PRKCZ_p → PRKCZ_p \|CTNNB1	V(189) = K(189,1) * [PRKCZ_p] * [CTNNB1] -K(189,2) * [PRKCZ_p \|CTNNB1];
R190	PRKCZ_p \|CTNNB1	CTNNB1_p + PRKCZ_p	PRKCZ_p \|CTNNB1 → CTNNB1_p + PRKCZ_p	V(190) = K(190,1) * [PRKCZ_p \|CTNNB1];
R191	SGK1 + SP1	SGK1 \|SP1	SGK1 + SP1 → SGK1 \|SP1	V(191) = K(191,1) * [SGK1] * [SP1] -K(191,2) * [SGK1 \|SP1];
R192	SGK1 \|SP1	SGK1 + SP1_p	SGK1 \|SP1 → SGK1 + SP1_p	V(192) = K(192,1) * [SGK1 \|SP1];
R193	PROM1 + SRC_p	SRC_p \|PROM1	PROM1 + SRC_p → SRC_p \|PROM1	V(193) = K(193,1) * [SRC_p] * [PROM1] -K(193,2) * [SRC_p \|PROM1];
R194	SRC_p \|PROM1	PROM1_p + SRC_p	SRC_p \|PROM1 → PROM1_p + SRC_p	V(194) = K(194,1) * [SRC_p \|PROM1];
R195	CTNNB1 + SRC_p	SRC_p \|CTNNB1	CTNNB1 + SRC_p → SRC_p \|CTNNB1	V(195) = K(195,1) * [SRC_p] * [CTNNB1] -K(195,2) * [SRC_p \|CTNNB1];
R196	SRC_p \|CTNNB1	CTNNB1_p + SRC_p	SRC_p \|CTNNB1 → CTNNB1_p + SRC_p	V(196) = K(196,1) * [SRC_p \|CTNNB1];
R197	MAPK1 + SGK1	SGK1 \|MAPK1	MAPK1 + SGK1 → SGK1 \|MAPK1	V(197) = K(197,1) * [SGK1] * [MAPK1] -K(197,2) * [SGK1 \|MAPK1];
R198	SGK1 \|MAPK1	MAPK1_p + SGK1	SGK1 \|MAPK1 → MAPK1_p + SGK1	V(198) = K(198,1) * [SGK1 \|MAPK1];
R199	DDIT3 + PRKAA1_p	PRKAA1_p \|DDIT3	DDIT3 + PRKAA1_p → PRKAA1_p \|DDIT3	V(199) = K(199,1) * [PRKAA1_p] * [DDIT3] -K(199,2) * [PRKAA1_p \|DDIT3];

Reaction ID	Reactants	Products	Original Text	ODE Equations
R1	SMAD2_p + SMAD4_p	SIGNOR-C8	SMAD2_p + SMAD4_p → SIGNOR-C8	V(1) = K(1,1) * [SMAD2_p] * [SMAD4_p] -K(1,2) * [SIGNOR-C8];
R2	SMAD3_p + SMAD4_p	SIGNOR-C9	SMAD3_p + SMAD4_p → SIGNOR-C9	V(2) = K(2,1) * [SMAD4_p] * [SMAD3_p] -K(2,2) * [SIGNOR-C9];
R3	JUN_p + SMAD4_p	SIGNOR-C10	JUN_p + SMAD4_p → SIGNOR-C10	V(3) = K(3,1) * [SMAD4_p] * [JUN_p] -K(3,2) * [SIGNOR-C10];
R4	NR3C1_p + STAT5A_p	SIGNOR-C84	NR3C1_p + STAT5A_p → SIGNOR-C84	V(4) = K(4,1) * [NR3C1_p] * [STAT5A_p] -K(4,2) * [SIGNOR-C84];
R5	JUN_p + SMAD3_p	SIGNOR-C86	JUN_p + SMAD3_p → SIGNOR-C86	V(5) = K(5,1) * [JUN_p] * [SMAD3_p] -K(5,2) * [SIGNOR-C86];
R6	FOS_p + FOS_p + FOS_p + FOS_p + JUN_p + JUN_p + JUN_p + JUN_p	SIGNOR-C154	FOS_p + FOS_p + FOS_p + FOS_p + JUN_p + JUN_p + JUN_p + JUN_p → SIGNOR-C154	V(6) = K(6,1) * [FOS_p] * [JUN_p] * [JUN_p] * [FOS_p] * [JUN_p] * [FOS_p] * [FOS_p] * [JUN_p] -K(6,2) * [SIGNOR-C154];
R7	EP300 + MAPK1_p	MAPK1_p \|EP300	EP300 + MAPK1_p → MAPK1_p \|EP300	V(7) = K(7,1) * [MAPK1_p] * [EP300] -K(7,2) * [MAPK1_p \|EP300];
R8	MAPK1_p \|EP300	EP300_p + MAPK1_p	MAPK1_p \|EP300 → EP300_p + MAPK1_p	V(8) = K(8,1) * [MAPK1_p \|EP300];
R9	HIF1A + MAPK1_p	MAPK1_p \|HIF1A	HIF1A + MAPK1_p → MAPK1_p \|HIF1A	V(9) = K(9,1) * [MAPK1_p] * [HIF1A] -K(9,2) * [MAPK1_p \|HIF1A];
R10	MAPK1_p \|HIF1A	HIF1A_p + MAPK1_p	MAPK1_p \|HIF1A → HIF1A_p + MAPK1_p	V(10) = K(10,1) * [MAPK1_p \|HIF1A];
R11	MAPK1_p + NR3C1	MAPK1_p \|NR3C1	MAPK1_p + NR3C1 → MAPK1_p \|NR3C1	V(11) = K(11,1) * [MAPK1_p] * [NR3C1] -K(11,2) * [MAPK1_p \|NR3C1];
R12	MAPK1_p \|NR3C1	MAPK1_p + NR3C1_p	MAPK1_p \|NR3C1 → MAPK1_p + NR3C1_p	V(12) = K(12,1) * [MAPK1_p \|NR3C1];
R13	AKT1_p + FOXO1	AKT1_p \|FOXO1	AKT1_p + FOXO1 → AKT1_p \|FOXO1	V(13) = K(13,1) * [AKT1_p] * [FOXO1] -K(13,2) * [AKT1_p \|FOXO1];
R14	AKT1_p \|FOXO1	AKT1_p + FOXO1_p	AKT1_p \|FOXO1 → AKT1_p + FOXO1_p	V(14) = K(14,1) * [AKT1_p \|FOXO1];
R15	MAPK1_p + PRDX6	MAPK1_p \|PRDX6	MAPK1_p + PRDX6 → MAPK1_p \|PRDX6	V(15) = K(15,1) * [MAPK1_p] * [PRDX6] -K(15,2) * [MAPK1_p \|PRDX6];
R16	MAPK1_p \|PRDX6	MAPK1_p + PRDX6_p	MAPK1_p \|PRDX6 → MAPK1_p + PRDX6_p	V(16) = K(16,1) * [MAPK1_p \|PRDX6];
R17	PRKCZ_p + SP1	PRKCZ_p \|SP1	PRKCZ_p + SP1 → PRKCZ_p \|SP1	V(17) = K(17,1) * [PRKCZ_p] * [SP1] -K(17,2) * [PRKCZ_p \|SP1];
R18	PRKCZ_p \|SP1	PRKCZ_p + SP1_p	PRKCZ_p \|SP1 → PRKCZ_p + SP1_p	V(18) = K(18,1) * [PRKCZ_p \|SP1];
R19	MAPK1_p + RPS6KB1	MAPK1_p \|RPS6KB1	MAPK1_p + RPS6KB1 → MAPK1_p \|RPS6KB1	V(19) = K(19,1) * [MAPK1_p] * [RPS6KB1] -K(19,2) * [MAPK1_p \|RPS6KB1];
R20	MAPK1_p \|RPS6KB1	MAPK1_p + RPS6KB1_p	MAPK1_p \|RPS6KB1 → MAPK1_p + RPS6KB1_p	V(20) = K(20,1) * [MAPK1_p \|RPS6KB1];
R21	AKT1_p + PRKAA1	AKT1_p \|PRKAA1	AKT1_p + PRKAA1 → AKT1_p \|PRKAA1	V(21) = K(21,1) * [AKT1_p] * [PRKAA1] -K(21,2) * [AKT1_p \|PRKAA1];
R22	AKT1_p \|PRKAA1	AKT1_p + PRKAA1_p	AKT1_p \|PRKAA1 → AKT1_p + PRKAA1_p	V(22) = K(22,1) * [AKT1_p \|PRKAA1];
R23	EGFR + EGFR_p	EGFR_p \|EGFR	EGFR + EGFR_p → EGFR_p \|EGFR	V(23) = K(23,1) * [EGFR_p] * [EGFR] -K(23,2) * [EGFR_p \|EGFR];
R24	EGFR_p \|EGFR	EGFR_p + EGFR_p	EGFR_p \|EGFR → EGFR_p + EGFR_p	V(24) = K(24,1) * [EGFR_p \|EGFR];
R25	IKBKB + IKBKB_p	IKBKB_p \|IKBKB	IKBKB + IKBKB_p → IKBKB_p \|IKBKB	V(25) = K(25,1) * [IKBKB_p] * [IKBKB] -K(25,2) * [IKBKB_p \|IKBKB];
R26	IKBKB_p \|IKBKB	IKBKB_p + IKBKB_p	IKBKB_p \|IKBKB → IKBKB_p + IKBKB_p	V(26) = K(26,1) * [IKBKB_p \|IKBKB];
R27	CDKN1B + MAPK1_p	MAPK1_p \|CDKN1B	CDKN1B + MAPK1_p → MAPK1_p \|CDKN1B	V(27) = K(27,1) * [MAPK1_p] * [CDKN1B] -K(27,2) * [MAPK1_p \|CDKN1B];
R28	MAPK1_p \|CDKN1B	CDKN1B_p + MAPK1_p	MAPK1_p \|CDKN1B → CDKN1B_p + MAPK1_p	V(28) = K(28,1) * [MAPK1_p \|CDKN1B];
R29	MAPK1_p + SMAD4	MAPK1_p \|SMAD4	MAPK1_p + SMAD4 → MAPK1_p \|SMAD4	V(29) = K(29,1) * [MAPK1_p] * [SMAD4] -K(29,2) * [MAPK1_p \|SMAD4];
R30	MAPK1_p \|SMAD4	MAPK1_p + SMAD4_p	MAPK1_p \|SMAD4 → MAPK1_p + SMAD4_p	V(30) = K(30,1) * [MAPK1_p \|SMAD4];
R31	ESR1 + MAPK1_p	MAPK1_p \|ESR1	ESR1 + MAPK1_p → MAPK1_p \|ESR1	V(31) = K(31,1) * [MAPK1_p] * [ESR1] -K(31,2) * [MAPK1_p \|ESR1];
R32	MAPK1_p \|ESR1	ESR1_p + MAPK1_p	MAPK1_p \|ESR1 → ESR1_p + MAPK1_p	V(32) = K(32,1) * [MAPK1_p \|ESR1];
R33	MAPK1_p + STK11	MAPK1_p \|STK11	MAPK1_p + STK11 → MAPK1_p \|STK11	V(33) = K(33,1) * [MAPK1_p] * [STK11] -K(33,2) * [MAPK1_p \|STK11];
R34	MAPK1_p \|STK11	MAPK1_p + STK11_p	MAPK1_p \|STK11 → MAPK1_p + STK11_p	V(34) = K(34,1) * [MAPK1_p \|STK11];
R35	JUN + MAPK1_p	MAPK1_p \|JUN	JUN + MAPK1_p → MAPK1_p \|JUN	V(35) = K(35,1) * [MAPK1_p] * [JUN] -K(35,2) * [MAPK1_p \|JUN];
R36	MAPK1_p \|JUN	JUN_p + MAPK1_p	MAPK1_p \|JUN → JUN_p + MAPK1_p	V(36) = K(36,1) * [MAPK1_p \|JUN];
R37	AKT1_p + NR4A1	AKT1_p \|NR4A1	AKT1_p + NR4A1 → AKT1_p \|NR4A1	V(37) = K(37,1) * [AKT1_p] * [NR4A1] -K(37,2) * [AKT1_p \|NR4A1];
R38	AKT1_p \|NR4A1	AKT1_p + NR4A1_p	AKT1_p \|NR4A1 → AKT1_p + NR4A1_p	V(38) = K(38,1) * [AKT1_p \|NR4A1];
R39	FOS + MAPK1_p	MAPK1_p \|FOS	FOS + MAPK1_p → MAPK1_p \|FOS	V(39) = K(39,1) * [MAPK1_p] * [FOS] -K(39,2) * [MAPK1_p \|FOS];
R40	MAPK1_p \|FOS	FOS_p + MAPK1_p	MAPK1_p \|FOS → FOS_p + MAPK1_p	V(40) = K(40,1) * [MAPK1_p \|FOS];
R41	STK11 + STK11_p	STK11_p \|STK11	STK11 + STK11_p → STK11_p \|STK11	V(41) = K(41,1) * [STK11_p] * [STK11] -K(41,2) * [STK11_p \|STK11];
R42	STK11_p \|STK11	STK11_p + STK11_p	STK11_p \|STK11 → STK11_p + STK11_p	V(42) = K(42,1) * [STK11_p \|STK11];
R43	SRC + SRC_p	SRC_p \|SRC	SRC + SRC_p → SRC_p \|SRC	V(43) = K(43,1) * [SRC_p] * [SRC] -K(43,2) * [SRC_p \|SRC];
R44	SRC_p \|SRC	SRC_p + SRC_p	SRC_p \|SRC → SRC_p + SRC_p	V(44) = K(44,1) * [SRC_p \|SRC];
R45	SRC_p + TLR3	SRC_p \|TLR3	SRC_p + TLR3 → SRC_p \|TLR3	V(45) = K(45,1) * [SRC_p] * [TLR3] -K(45,2) * [SRC_p \|TLR3];
R46	SRC_p \|TLR3	SRC_p + TLR3_p	SRC_p \|TLR3 → SRC_p + TLR3_p	V(46) = K(46,1) * [SRC_p \|TLR3];
R47	MAPK1_p + SMAD2	MAPK1_p \|SMAD2	MAPK1_p + SMAD2 → MAPK1_p \|SMAD2	V(47) = K(47,1) * [MAPK1_p] * [SMAD2] -K(47,2) * [MAPK1_p \|SMAD2];
R48	MAPK1_p \|SMAD2	MAPK1_p + SMAD2_p	MAPK1_p \|SMAD2 → MAPK1_p + SMAD2_p	V(48) = K(48,1) * [MAPK1_p \|SMAD2];
R49	MAPK1_p + RORA	MAPK1_p \|RORA	MAPK1_p + RORA → MAPK1_p \|RORA	V(49) = K(49,1) * [MAPK1_p] * [RORA] -K(49,2) * [MAPK1_p \|RORA];
R50	MAPK1_p \|RORA	MAPK1_p + RORA_p	MAPK1_p \|RORA → MAPK1_p + RORA_p	V(50) = K(50,1) * [MAPK1_p \|RORA];
R51	PPARGC1A + PRKAA1_p	PRKAA1_p \|PPARGC1A	PPARGC1A + PRKAA1_p → PRKAA1_p \|PPARGC1A	V(51) = K(51,1) * [PRKAA1_p] * [PPARGC1A] -K(51,2) * [PRKAA1_p \|PPARGC1A];
R52	PRKAA1_p \|PPARGC1A	PPARGC1A_p + PRKAA1_p	PRKAA1_p \|PPARGC1A → PPARGC1A_p + PRKAA1_p	V(52) = K(52,1) * [PRKAA1_p \|PPARGC1A];
R53	INSR + INSR_p	INSR_p \|INSR	INSR + INSR_p → INSR_p \|INSR	V(53) = K(53,1) * [INSR_p] * [INSR] -K(53,2) * [INSR_p \|INSR];
R54	INSR_p \|INSR	INSR_p + INSR_p	INSR_p \|INSR → INSR_p + INSR_p	V(54) = K(54,1) * [INSR_p \|INSR];
R55	JAK1_p + STAT1	JAK1_p \|STAT1	JAK1_p + STAT1 → JAK1_p \|STAT1	V(55) = K(55,1) * [JAK1_p] * [STAT1] -K(55,2) * [JAK1_p \|STAT1];
R56	JAK1_p \|STAT1	JAK1_p + STAT1_p	JAK1_p \|STAT1 → JAK1_p + STAT1_p	V(56) = K(56,1) * [JAK1_p \|STAT1];
R57	DUSP1 + MAPK1_p	MAPK1_p \|DUSP1	DUSP1 + MAPK1_p → MAPK1_p \|DUSP1	V(57) = K(57,1) * [MAPK1_p] * [DUSP1] -K(57,2) * [MAPK1_p \|DUSP1];
R58	MAPK1_p \|DUSP1	DUSP1_p + MAPK1_p	MAPK1_p \|DUSP1 → DUSP1_p + MAPK1_p	V(58) = K(58,1) * [MAPK1_p \|DUSP1];
R59	AKT1_p + HSPB1	AKT1_p \|HSPB1	AKT1_p + HSPB1 → AKT1_p \|HSPB1	V(59) = K(59,1) * [AKT1_p] * [HSPB1] -K(59,2) * [AKT1_p \|HSPB1];
R60	AKT1_p \|HSPB1	AKT1_p + HSPB1_p	AKT1_p \|HSPB1 → AKT1_p + HSPB1_p	V(60) = K(60,1) * [AKT1_p \|HSPB1];
R61	HSPB1 + RPS6KB1_p	RPS6KB1_p \|HSPB1	HSPB1 + RPS6KB1_p → RPS6KB1_p \|HSPB1	V(61) = K(61,1) * [RPS6KB1_p] * [HSPB1] -K(61,2) * [RPS6KB1_p \|HSPB1];
R62	RPS6KB1_p \|HSPB1	HSPB1_p + RPS6KB1_p	RPS6KB1_p \|HSPB1 → HSPB1_p + RPS6KB1_p	V(62) = K(62,1) * [RPS6KB1_p \|HSPB1];
R63	AKT1_p + CDKN1A	AKT1_p \|CDKN1A	AKT1_p + CDKN1A → AKT1_p \|CDKN1A	V(63) = K(63,1) * [AKT1_p] * [CDKN1A] -K(63,2) * [AKT1_p \|CDKN1A];
R64	AKT1_p \|CDKN1A	AKT1_p + CDKN1A_p	AKT1_p \|CDKN1A → AKT1_p + CDKN1A_p	V(64) = K(64,1) * [AKT1_p \|CDKN1A];
R65	AKT1 + SRC_p	SRC_p \|AKT1	AKT1 + SRC_p → SRC_p \|AKT1	V(65) = K(65,1) * [SRC_p] * [AKT1] -K(65,2) * [SRC_p \|AKT1];
R66	SRC_p \|AKT1	AKT1_p + SRC_p	SRC_p \|AKT1 → AKT1_p + SRC_p	V(66) = K(66,1) * [SRC_p \|AKT1];
R67	EIF2AK3 + JAK1_p	JAK1_p \|EIF2AK3	EIF2AK3 + JAK1_p → JAK1_p \|EIF2AK3	V(67) = K(67,1) * [JAK1_p] * [EIF2AK3] -K(67,2) * [JAK1_p \|EIF2AK3];
R68	JAK1_p \|EIF2AK3	EIF2AK3_p + JAK1_p	JAK1_p \|EIF2AK3 → EIF2AK3_p + JAK1_p	V(68) = K(68,1) * [JAK1_p \|EIF2AK3];
R69	AKT1_p + ESR1	AKT1_p \|ESR1	AKT1_p + ESR1 → AKT1_p \|ESR1	V(69) = K(69,1) * [AKT1_p] * [ESR1] -K(69,2) * [AKT1_p \|ESR1];
R70	AKT1_p \|ESR1	AKT1_p + ESR1_p	AKT1_p \|ESR1 → AKT1_p + ESR1_p	V(70) = K(70,1) * [AKT1_p \|ESR1];
R71	MAPK1_p + RHOA	MAPK1_p \|RHOA	MAPK1_p + RHOA → MAPK1_p \|RHOA	V(71) = K(71,1) * [MAPK1_p] * [RHOA] -K(71,2) * [MAPK1_p \|RHOA];
R72	MAPK1_p \|RHOA	MAPK1_p + RHOA_p	MAPK1_p \|RHOA → MAPK1_p + RHOA_p	V(72) = K(72,1) * [MAPK1_p \|RHOA];
R73	CALM1 + EGFR_p	EGFR_p \|CALM1	CALM1 + EGFR_p → EGFR_p \|CALM1	V(73) = K(73,1) * [EGFR_p] * [CALM1] -K(73,2) * [EGFR_p \|CALM1];
R74	EGFR_p \|CALM1	CALM1_p + EGFR_p	EGFR_p \|CALM1 → CALM1_p + EGFR_p	V(74) = K(74,1) * [EGFR_p \|CALM1];
R75	AKT1_p + PPARGC1A	AKT1_p \|PPARGC1A	AKT1_p + PPARGC1A → AKT1_p \|PPARGC1A	V(75) = K(75,1) * [AKT1_p] * [PPARGC1A] -K(75,2) * [AKT1_p \|PPARGC1A];
R76	AKT1_p \|PPARGC1A	AKT1_p + PPARGC1A_p	AKT1_p \|PPARGC1A → AKT1_p + PPARGC1A_p	V(76) = K(76,1) * [AKT1_p \|PPARGC1A];
R77	FOXO1 + MAPK1_p	MAPK1_p \|FOXO1	FOXO1 + MAPK1_p → MAPK1_p \|FOXO1	V(77) = K(77,1) * [MAPK1_p] * [FOXO1] -K(77,2) * [MAPK1_p \|FOXO1];
R78	MAPK1_p \|FOXO1	FOXO1_p + MAPK1_p	MAPK1_p \|FOXO1 → FOXO1_p + MAPK1_p	V(78) = K(78,1) * [MAPK1_p \|FOXO1];
R79	EGFR + SRC_p	SRC_p \|EGFR	EGFR + SRC_p → SRC_p \|EGFR	V(79) = K(79,1) * [SRC_p] * [EGFR] -K(79,2) * [SRC_p \|EGFR];
R80	SRC_p \|EGFR	EGFR_p + SRC_p	SRC_p \|EGFR → EGFR_p + SRC_p	V(80) = K(80,1) * [SRC_p \|EGFR];
R81	SRC_p + STAT1	SRC_p \|STAT1	SRC_p + STAT1 → SRC_p \|STAT1	V(81) = K(81,1) * [SRC_p] * [STAT1] -K(81,2) * [SRC_p \|STAT1];
R82	SRC_p \|STAT1	SRC_p + STAT1_p	SRC_p \|STAT1 → SRC_p + STAT1_p	V(82) = K(82,1) * [SRC_p \|STAT1];
R83	MAPK1_p + SMAD3	MAPK1_p \|SMAD3	MAPK1_p + SMAD3 → MAPK1_p \|SMAD3	V(83) = K(83,1) * [MAPK1_p] * [SMAD3] -K(83,2) * [MAPK1_p \|SMAD3];
R84	MAPK1_p \|SMAD3	MAPK1_p + SMAD3_p	MAPK1_p \|SMAD3 → MAPK1_p + SMAD3_p	V(84) = K(84,1) * [MAPK1_p \|SMAD3];
R85	MAPK1_p + TFEB	MAPK1_p \|TFEB	MAPK1_p + TFEB → MAPK1_p \|TFEB	V(85) = K(85,1) * [MAPK1_p] * [TFEB] -K(85,2) * [MAPK1_p \|TFEB];
R86	MAPK1_p \|TFEB	MAPK1_p + TFEB_p	MAPK1_p \|TFEB → MAPK1_p + TFEB_p	V(86) = K(86,1) * [MAPK1_p \|TFEB];
R87	CALM1 + INSR_p	INSR_p \|CALM1	CALM1 + INSR_p → INSR_p \|CALM1	V(87) = K(87,1) * [INSR_p] * [CALM1] -K(87,2) * [INSR_p \|CALM1];
R88	INSR_p \|CALM1	CALM1_p + INSR_p	INSR_p \|CALM1 → CALM1_p + INSR_p	V(88) = K(88,1) * [INSR_p \|CALM1];
R89	ERN1 + ERN1_p	ERN1_p \|ERN1	ERN1 + ERN1_p → ERN1_p \|ERN1	V(89) = K(89,1) * [ERN1_p] * [ERN1] -K(89,2) * [ERN1_p \|ERN1];
R90	ERN1_p \|ERN1	ERN1_p + ERN1_p	ERN1_p \|ERN1 → ERN1_p + ERN1_p	V(90) = K(90,1) * [ERN1_p \|ERN1];
R91	SRC_p + TRAF6	SRC_p \|TRAF6	SRC_p + TRAF6 → SRC_p \|TRAF6	V(91) = K(91,1) * [SRC_p] * [TRAF6] -K(91,2) * [SRC_p \|TRAF6];
R92	SRC_p \|TRAF6	SRC_p + TRAF6_p	SRC_p \|TRAF6 → SRC_p + TRAF6_p	V(92) = K(92,1) * [SRC_p \|TRAF6];
R93	AKT1_p + CDKN1B	AKT1_p \|CDKN1B	AKT1_p + CDKN1B → AKT1_p \|CDKN1B	V(93) = K(93,1) * [AKT1_p] * [CDKN1B] -K(93,2) * [AKT1_p \|CDKN1B];
R94	AKT1_p \|CDKN1B	AKT1_p + CDKN1B_p	AKT1_p \|CDKN1B → AKT1_p + CDKN1B_p	V(94) = K(94,1) * [AKT1_p \|CDKN1B];
R95	BAX + PRKCZ_p	PRKCZ_p \|BAX	BAX + PRKCZ_p → PRKCZ_p \|BAX	V(95) = K(95,1) * [PRKCZ_p] * [BAX] -K(95,2) * [PRKCZ_p \|BAX];
R96	PRKCZ_p \|BAX	BAX_p + PRKCZ_p	PRKCZ_p \|BAX → BAX_p + PRKCZ_p	V(96) = K(96,1) * [PRKCZ_p \|BAX];
R97	PRKCZ_p + YAP1	PRKCZ_p \|YAP1	PRKCZ_p + YAP1 → PRKCZ_p \|YAP1	V(97) = K(97,1) * [PRKCZ_p] * [YAP1] -K(97,2) * [PRKCZ_p \|YAP1];
R98	PRKCZ_p \|YAP1	PRKCZ_p + YAP1_p	PRKCZ_p \|YAP1 → PRKCZ_p + YAP1_p	V(98) = K(98,1) * [PRKCZ_p \|YAP1];
R99	MAPK1_p + SIGNOR-C154	MAPK1_p \|SIGNOR-C154	MAPK1_p + SIGNOR-C154 → MAPK1_p \|SIGNOR-C154	V(99) = K(99,1) * [MAPK1_p] * [SIGNOR-C154] -K(99,2) * [MAPK1_p \|SIGNOR-C154];
R100	MAPK1_p \|SIGNOR-C154	MAPK1_p + SIGNOR-C154_p	MAPK1_p \|SIGNOR-C154 → MAPK1_p + SIGNOR-C154_p	V(100) = K(100,1) * [MAPK1_p \|SIGNOR-C154];
R101	MAPK1_p + PPARA	MAPK1_p \|PPARA	MAPK1_p + PPARA → MAPK1_p \|PPARA	V(101) = K(101,1) * [MAPK1_p] * [PPARA] -K(101,2) * [MAPK1_p \|PPARA];
R102	MAPK1_p \|PPARA	MAPK1_p + PPARA_p	MAPK1_p \|PPARA → MAPK1_p + PPARA_p	V(102) = K(102,1) * [MAPK1_p \|PPARA];
R103	PRKCZ_p + VIM	PRKCZ_p \|VIM	PRKCZ_p + VIM → PRKCZ_p \|VIM	V(103) = K(103,1) * [PRKCZ_p] * [VIM] -K(103,2) * [PRKCZ_p \|VIM];
R104	PRKCZ_p \|VIM	PRKCZ_p + VIM_p	PRKCZ_p \|VIM → PRKCZ_p + VIM_p	V(104) = K(104,1) * [PRKCZ_p \|VIM];
R105	PTEN + STK11_p	STK11_p \|PTEN	PTEN + STK11_p → STK11_p \|PTEN	V(105) = K(105,1) * [STK11_p] * [PTEN] -K(105,2) * [STK11_p \|PTEN];
R106	STK11_p \|PTEN	PTEN_p + STK11_p	STK11_p \|PTEN → PTEN_p + STK11_p	V(106) = K(106,1) * [STK11_p \|PTEN];
R107	FOXO1 + SGK1	SGK1 \|FOXO1	FOXO1 + SGK1 → SGK1 \|FOXO1	V(107) = K(107,1) * [SGK1] * [FOXO1] -K(107,2) * [SGK1 \|FOXO1];
R108	SGK1 \|FOXO1	FOXO1_p + SGK1	SGK1 \|FOXO1 → FOXO1_p + SGK1	V(108) = K(108,1) * [SGK1 \|FOXO1];
R109	CDKN1B + SGK1	SGK1 \|CDKN1B	CDKN1B + SGK1 → SGK1 \|CDKN1B	V(109) = K(109,1) * [SGK1] * [CDKN1B] -K(109,2) * [SGK1 \|CDKN1B];
R110	SGK1 \|CDKN1B	CDKN1B_p + SGK1	SGK1 \|CDKN1B → CDKN1B_p + SGK1	V(110) = K(110,1) * [SGK1 \|CDKN1B];
R111	AKT1_p + EP300	AKT1_p \|EP300	AKT1_p + EP300 → AKT1_p \|EP300	V(111) = K(111,1) * [AKT1_p] * [EP300] -K(111,2) * [AKT1_p \|EP300];
R112	AKT1_p \|EP300	AKT1_p + EP300_p	AKT1_p \|EP300 → AKT1_p + EP300_p	V(112) = K(112,1) * [AKT1_p \|EP300];
R113	FOXO1 + IKBKB_p	IKBKB_p \|FOXO1	FOXO1 + IKBKB_p → IKBKB_p \|FOXO1	V(113) = K(113,1) * [IKBKB_p] * [FOXO1] -K(113,2) * [IKBKB_p \|FOXO1];
R114	IKBKB_p \|FOXO1	FOXO1_p + IKBKB_p	IKBKB_p \|FOXO1 → FOXO1_p + IKBKB_p	V(114) = K(114,1) * [IKBKB_p \|FOXO1];
R115	EGFR + MAPK1_p	MAPK1_p \|EGFR	EGFR + MAPK1_p → MAPK1_p \|EGFR	V(115) = K(115,1) * [MAPK1_p] * [EGFR] -K(115,2) * [MAPK1_p \|EGFR];
R116	MAPK1_p \|EGFR	EGFR_p + MAPK1_p	MAPK1_p \|EGFR → EGFR_p + MAPK1_p	V(116) = K(116,1) * [MAPK1_p \|EGFR];
R117	PTEN + SRC_p	SRC_p \|PTEN	PTEN + SRC_p → SRC_p \|PTEN	V(117) = K(117,1) * [SRC_p] * [PTEN] -K(117,2) * [SRC_p \|PTEN];
R118	SRC_p \|PTEN	PTEN_p + SRC_p	SRC_p \|PTEN → PTEN_p + SRC_p	V(118) = K(118,1) * [SRC_p \|PTEN];
R119	EIF2AK3 + EIF2AK3_p	EIF2AK3_p \|EIF2AK3	EIF2AK3 + EIF2AK3_p → EIF2AK3_p \|EIF2AK3	V(119) = K(119,1) * [EIF2AK3_p] * [EIF2AK3] -K(119,2) * [EIF2AK3_p \|EIF2AK3];
R120	EIF2AK3_p \|EIF2AK3	EIF2AK3_p + EIF2AK3_p	EIF2AK3_p \|EIF2AK3 → EIF2AK3_p + EIF2AK3_p	V(120) = K(120,1) * [EIF2AK3_p \|EIF2AK3];
R121	ESR1 + RPS6KB1_p	RPS6KB1_p \|ESR1	ESR1 + RPS6KB1_p → RPS6KB1_p \|ESR1	V(121) = K(121,1) * [RPS6KB1_p] * [ESR1] -K(121,2) * [RPS6KB1_p \|ESR1];
R122	RPS6KB1_p \|ESR1	ESR1_p + RPS6KB1_p	RPS6KB1_p \|ESR1 → ESR1_p + RPS6KB1_p	V(122) = K(122,1) * [RPS6KB1_p \|ESR1];
R123	AKT1_p + VIM	AKT1_p \|VIM	AKT1_p + VIM → AKT1_p \|VIM	V(123) = K(123,1) * [AKT1_p] * [VIM] -K(123,2) * [AKT1_p \|VIM];
R124	AKT1_p \|VIM	AKT1_p + VIM_p	AKT1_p \|VIM → AKT1_p + VIM_p	V(124) = K(124,1) * [AKT1_p \|VIM];
R125	PRKCZ + PRKCZ_p	PRKCZ_p \|PRKCZ	PRKCZ + PRKCZ_p → PRKCZ_p \|PRKCZ	V(125) = K(125,1) * [PRKCZ_p] * [PRKCZ] -K(125,2) * [PRKCZ_p \|PRKCZ];
R126	PRKCZ_p \|PRKCZ	PRKCZ_p + PRKCZ_p	PRKCZ_p \|PRKCZ → PRKCZ_p + PRKCZ_p	V(126) = K(126,1) * [PRKCZ_p \|PRKCZ];
R127	DNMT1 + PRKAA1_p	PRKAA1_p \|DNMT1	DNMT1 + PRKAA1_p → PRKAA1_p \|DNMT1	V(127) = K(127,1) * [PRKAA1_p] * [DNMT1] -K(127,2) * [PRKAA1_p \|DNMT1];
R128	PRKAA1_p \|DNMT1	DNMT1_p + PRKAA1_p	PRKAA1_p \|DNMT1 → DNMT1_p + PRKAA1_p	V(128) = K(128,1) * [PRKAA1_p \|DNMT1];
R129	AKT1 + ILK_p	ILK_p \|AKT1	AKT1 + ILK_p → ILK_p \|AKT1	V(129) = K(129,1) * [ILK_p] * [AKT1] -K(129,2) * [ILK_p \|AKT1];
R130	ILK_p \|AKT1	AKT1_p + ILK_p	ILK_p \|AKT1 → AKT1_p + ILK_p	V(130) = K(130,1) * [ILK_p \|AKT1];
R131	MAPK1_p + SP1	MAPK1_p \|SP1	MAPK1_p + SP1 → MAPK1_p \|SP1	V(131) = K(131,1) * [MAPK1_p] * [SP1] -K(131,2) * [MAPK1_p \|SP1];
R132	MAPK1_p \|SP1	MAPK1_p + SP1_p	MAPK1_p \|SP1 → MAPK1_p + SP1_p	V(132) = K(132,1) * [MAPK1_p \|SP1];
R133	PRKCZ_p + STK11	PRKCZ_p \|STK11	PRKCZ_p + STK11 → PRKCZ_p \|STK11	V(133) = K(133,1) * [PRKCZ_p] * [STK11] -K(133,2) * [PRKCZ_p \|STK11];
R134	PRKCZ_p \|STK11	PRKCZ_p + STK11_p	PRKCZ_p \|STK11 → PRKCZ_p + STK11_p	V(134) = K(134,1) * [PRKCZ_p \|STK11];
R135	MAPK1_p + STAT5A	MAPK1_p \|STAT5A	MAPK1_p + STAT5A → MAPK1_p \|STAT5A	V(135) = K(135,1) * [MAPK1_p] * [STAT5A] -K(135,2) * [MAPK1_p \|STAT5A];
R136	MAPK1_p \|STAT5A	MAPK1_p + STAT5A_p	MAPK1_p \|STAT5A → MAPK1_p + STAT5A_p	V(136) = K(136,1) * [MAPK1_p \|STAT5A];
R137	PTPRJ + SRC_p	SRC_p \|PTPRJ	PTPRJ + SRC_p → SRC_p \|PTPRJ	V(137) = K(137,1) * [SRC_p] * [PTPRJ] -K(137,2) * [SRC_p \|PTPRJ];
R138	SRC_p \|PTPRJ	PTPRJ_p + SRC_p	SRC_p \|PTPRJ → PTPRJ_p + SRC_p	V(138) = K(138,1) * [SRC_p \|PTPRJ];
R139	CDKN1A + MAPK1_p	MAPK1_p \|CDKN1A	CDKN1A + MAPK1_p → MAPK1_p \|CDKN1A	V(139) = K(139,1) * [MAPK1_p] * [CDKN1A] -K(139,2) * [MAPK1_p \|CDKN1A];
R140	MAPK1_p \|CDKN1A	CDKN1A_p + MAPK1_p	MAPK1_p \|CDKN1A → CDKN1A_p + MAPK1_p	V(140) = K(140,1) * [MAPK1_p \|CDKN1A];
R141	FOXO1 + PRKAA1_p	PRKAA1_p \|FOXO1	FOXO1 + PRKAA1_p → PRKAA1_p \|FOXO1	V(141) = K(141,1) * [PRKAA1_p] * [FOXO1] -K(141,2) * [PRKAA1_p \|FOXO1];
R142	PRKAA1_p \|FOXO1	FOXO1_p + PRKAA1_p	PRKAA1_p \|FOXO1 → FOXO1_p + PRKAA1_p	V(142) = K(142,1) * [PRKAA1_p \|FOXO1];
R143	RAPGEF1 + SRC_p	SRC_p \|RAPGEF1	RAPGEF1 + SRC_p → SRC_p \|RAPGEF1	V(143) = K(143,1) * [SRC_p] * [RAPGEF1] -K(143,2) * [SRC_p \|RAPGEF1];
R144	SRC_p \|RAPGEF1	RAPGEF1_p + SRC_p	SRC_p \|RAPGEF1 → RAPGEF1_p + SRC_p	V(144) = K(144,1) * [SRC_p \|RAPGEF1];
R145	KRT19 + SRC_p	SRC_p \|KRT19	KRT19 + SRC_p → SRC_p \|KRT19	V(145) = K(145,1) * [SRC_p] * [KRT19] -K(145,2) * [SRC_p \|KRT19];
R146	SRC_p \|KRT19	KRT19_p + SRC_p	SRC_p \|KRT19 → KRT19_p + SRC_p	V(146) = K(146,1) * [SRC_p \|KRT19];
R147	AKT1_p + CASP9	AKT1_p \|CASP9	AKT1_p + CASP9 → AKT1_p \|CASP9	V(147) = K(147,1) * [AKT1_p] * [CASP9] -K(147,2) * [AKT1_p \|CASP9];
R148	AKT1_p \|CASP9	AKT1_p + CASP9_p	AKT1_p \|CASP9 → AKT1_p + CASP9_p	V(148) = K(148,1) * [AKT1_p \|CASP9];
R149	AKT1_p + NR3C1	AKT1_p \|NR3C1	AKT1_p + NR3C1 → AKT1_p \|NR3C1	V(149) = K(149,1) * [AKT1_p] * [NR3C1] -K(149,2) * [AKT1_p \|NR3C1];
R150	AKT1_p \|NR3C1	AKT1_p + NR3C1_p	AKT1_p \|NR3C1 → AKT1_p + NR3C1_p	V(150) = K(150,1) * [AKT1_p \|NR3C1];
R151	SMAD4 + STK11_p	STK11_p \|SMAD4	SMAD4 + STK11_p → STK11_p \|SMAD4	V(151) = K(151,1) * [STK11_p] * [SMAD4] -K(151,2) * [STK11_p \|SMAD4];
R152	STK11_p \|SMAD4	SMAD4_p + STK11_p	STK11_p \|SMAD4 → SMAD4_p + STK11_p	V(152) = K(152,1) * [STK11_p \|SMAD4];
R153	CASP9 + PRKCZ_p	PRKCZ_p \|CASP9	CASP9 + PRKCZ_p → PRKCZ_p \|CASP9	V(153) = K(153,1) * [PRKCZ_p] * [CASP9] -K(153,2) * [PRKCZ_p \|CASP9];
R154	PRKCZ_p \|CASP9	CASP9_p + PRKCZ_p	PRKCZ_p \|CASP9 → CASP9_p + PRKCZ_p	V(154) = K(154,1) * [PRKCZ_p \|CASP9];
R155	CASP9 + MAPK1_p	MAPK1_p \|CASP9	CASP9 + MAPK1_p → MAPK1_p \|CASP9	V(155) = K(155,1) * [MAPK1_p] * [CASP9] -K(155,2) * [MAPK1_p \|CASP9];
R156	MAPK1_p \|CASP9	CASP9_p + MAPK1_p	MAPK1_p \|CASP9 → CASP9_p + MAPK1_p	V(156) = K(156,1) * [MAPK1_p \|CASP9];
R157	IKBKB + SRC_p	SRC_p \|IKBKB	IKBKB + SRC_p → SRC_p \|IKBKB	V(157) = K(157,1) * [SRC_p] * [IKBKB] -K(157,2) * [SRC_p \|IKBKB];
R158	SRC_p \|IKBKB	IKBKB_p + SRC_p	SRC_p \|IKBKB → IKBKB_p + SRC_p	V(158) = K(158,1) * [SRC_p \|IKBKB];
R159	RICTOR + RPS6KB1_p	RPS6KB1_p \|RICTOR	RICTOR + RPS6KB1_p → RPS6KB1_p \|RICTOR	V(159) = K(159,1) * [RPS6KB1_p] * [RICTOR] -K(159,2) * [RPS6KB1_p \|RICTOR];
R160	RPS6KB1_p \|RICTOR	RICTOR_p + RPS6KB1_p	RPS6KB1_p \|RICTOR → RICTOR_p + RPS6KB1_p	V(160) = K(160,1) * [RPS6KB1_p \|RICTOR];
R161	JAK1_p + STAT6	JAK1_p \|STAT6	JAK1_p + STAT6 → JAK1_p \|STAT6	V(161) = K(161,1) * [JAK1_p] * [STAT6] -K(161,2) * [JAK1_p \|STAT6];
R162	JAK1_p \|STAT6	JAK1_p + STAT6_p	JAK1_p \|STAT6 → JAK1_p + STAT6_p	V(162) = K(162,1) * [JAK1_p \|STAT6];
R163	AKT1_p + YAP1	AKT1_p \|YAP1	AKT1_p + YAP1 → AKT1_p \|YAP1	V(163) = K(163,1) * [AKT1_p] * [YAP1] -K(163,2) * [AKT1_p \|YAP1];
R164	AKT1_p \|YAP1	AKT1_p + YAP1_p	AKT1_p \|YAP1 → AKT1_p + YAP1_p	V(164) = K(164,1) * [AKT1_p \|YAP1];
R165	AKT1_p + DNMT1	AKT1_p \|DNMT1	AKT1_p + DNMT1 → AKT1_p \|DNMT1	V(165) = K(165,1) * [AKT1_p] * [DNMT1] -K(165,2) * [AKT1_p \|DNMT1];
R166	AKT1_p \|DNMT1	AKT1_p + DNMT1_p	AKT1_p \|DNMT1 → AKT1_p + DNMT1_p	V(166) = K(166,1) * [AKT1_p \|DNMT1];
R167	EP300 + PRKAA1_p	PRKAA1_p \|EP300	EP300 + PRKAA1_p → PRKAA1_p \|EP300	V(167) = K(167,1) * [PRKAA1_p] * [EP300] -K(167,2) * [PRKAA1_p \|EP300];
R168	PRKAA1_p \|EP300	EP300_p + PRKAA1_p	PRKAA1_p \|EP300 → EP300_p + PRKAA1_p	V(168) = K(168,1) * [PRKAA1_p \|EP300];
R169	AKT1_p + CTNNB1	AKT1_p \|CTNNB1	AKT1_p + CTNNB1 → AKT1_p \|CTNNB1	V(169) = K(169,1) * [AKT1_p] * [CTNNB1] -K(169,2) * [AKT1_p \|CTNNB1];
R170	AKT1_p \|CTNNB1	AKT1_p + CTNNB1_p	AKT1_p \|CTNNB1 → AKT1_p + CTNNB1_p	V(170) = K(170,1) * [AKT1_p \|CTNNB1];
R171	MAP4K2 + MAP4K2_p	MAP4K2_p \|MAP4K2	MAP4K2 + MAP4K2_p → MAP4K2_p \|MAP4K2	V(171) = K(171,1) * [MAP4K2_p] * [MAP4K2] -K(171,2) * [MAP4K2_p \|MAP4K2];
R172	MAP4K2_p \|MAP4K2	MAP4K2_p + MAP4K2_p	MAP4K2_p \|MAP4K2 → MAP4K2_p + MAP4K2_p	V(172) = K(172,1) * [MAP4K2_p \|MAP4K2];
R173	STK11_p + YAP1	STK11_p \|YAP1	STK11_p + YAP1 → STK11_p \|YAP1	V(173) = K(173,1) * [STK11_p] * [YAP1] -K(173,2) * [STK11_p \|YAP1];
R174	STK11_p \|YAP1	STK11_p + YAP1_p	STK11_p \|YAP1 → STK11_p + YAP1_p	V(174) = K(174,1) * [STK11_p \|YAP1];
R175	MAPK1 + MAPK1_p	MAPK1_p \|MAPK1	MAPK1 + MAPK1_p → MAPK1_p \|MAPK1	V(175) = K(175,1) * [MAPK1_p] * [MAPK1] -K(175,2) * [MAPK1_p \|MAPK1];
R176	MAPK1_p \|MAPK1	MAPK1_p + MAPK1_p	MAPK1_p \|MAPK1 → MAPK1_p + MAPK1_p	V(176) = K(176,1) * [MAPK1_p \|MAPK1];
R177	MAPK1_p + RRAS	MAPK1_p \|RRAS	MAPK1_p + RRAS → MAPK1_p \|RRAS	V(177) = K(177,1) * [MAPK1_p] * [RRAS] -K(177,2) * [MAPK1_p \|RRAS];
R178	MAPK1_p \|RRAS	MAPK1_p + RRAS_p	MAPK1_p \|RRAS → MAPK1_p + RRAS_p	V(178) = K(178,1) * [MAPK1_p \|RRAS];
R179	CDH1 + SRC_p	SRC_p \|CDH1	CDH1 + SRC_p → SRC_p \|CDH1	V(179) = K(179,1) * [SRC_p] * [CDH1] -K(179,2) * [SRC_p \|CDH1];
R180	SRC_p \|CDH1	CDH1_p + SRC_p	SRC_p \|CDH1 → CDH1_p + SRC_p	V(180) = K(180,1) * [SRC_p \|CDH1];
R181	MAPK1_p + ZFP36	MAPK1_p \|ZFP36	MAPK1_p + ZFP36 → MAPK1_p \|ZFP36	V(181) = K(181,1) * [MAPK1_p] * [ZFP36] -K(181,2) * [MAPK1_p \|ZFP36];
R182	MAPK1_p \|ZFP36	MAPK1_p + ZFP36_p	MAPK1_p \|ZFP36 → MAPK1_p + ZFP36_p	V(182) = K(182,1) * [MAPK1_p \|ZFP36];
R183	AKT1_p + MAPKAP1	AKT1_p \|MAPKAP1	AKT1_p + MAPKAP1 → AKT1_p \|MAPKAP1	V(183) = K(183,1) * [AKT1_p] * [MAPKAP1] -K(183,2) * [AKT1_p \|MAPKAP1];
R184	AKT1_p \|MAPKAP1	AKT1_p + MAPKAP1_p	AKT1_p \|MAPKAP1 → AKT1_p + MAPKAP1_p	V(184) = K(184,1) * [AKT1_p \|MAPKAP1];
R185	MAPK1_p + RCAN1	MAPK1_p \|RCAN1	MAPK1_p + RCAN1 → MAPK1_p \|RCAN1	V(185) = K(185,1) * [MAPK1_p] * [RCAN1] -K(185,2) * [MAPK1_p \|RCAN1];
R186	MAPK1_p \|RCAN1	MAPK1_p + RCAN1_p	MAPK1_p \|RCAN1 → MAPK1_p + RCAN1_p	V(186) = K(186,1) * [MAPK1_p \|RCAN1];
R187	EGFR_p + ESR1	EGFR_p \|ESR1	EGFR_p + ESR1 → EGFR_p \|ESR1	V(187) = K(187,1) * [EGFR_p] * [ESR1] -K(187,2) * [EGFR_p \|ESR1];
R188	EGFR_p \|ESR1	EGFR_p + ESR1_p	EGFR_p \|ESR1 → EGFR_p + ESR1_p	V(188) = K(188,1) * [EGFR_p \|ESR1];
R189	CTNNB1 + PRKCZ_p	PRKCZ_p \|CTNNB1	CTNNB1 + PRKCZ_p → PRKCZ_p \|CTNNB1	V(189) = K(189,1) * [PRKCZ_p] * [CTNNB1] -K(189,2) * [PRKCZ_p \|CTNNB1];
R190	PRKCZ_p \|CTNNB1	CTNNB1_p + PRKCZ_p	PRKCZ_p \|CTNNB1 → CTNNB1_p + PRKCZ_p	V(190) = K(190,1) * [PRKCZ_p \|CTNNB1];
R191	SGK1 + SP1	SGK1 \|SP1	SGK1 + SP1 → SGK1 \|SP1	V(191) = K(191,1) * [SGK1] * [SP1] -K(191,2) * [SGK1 \|SP1];
R192	SGK1 \|SP1	SGK1 + SP1_p	SGK1 \|SP1 → SGK1 + SP1_p	V(192) = K(192,1) * [SGK1 \|SP1];
R193	PROM1 + SRC_p	SRC_p \|PROM1	PROM1 + SRC_p → SRC_p \|PROM1	V(193) = K(193,1) * [SRC_p] * [PROM1] -K(193,2) * [SRC_p \|PROM1];
R194	SRC_p \|PROM1	PROM1_p + SRC_p	SRC_p \|PROM1 → PROM1_p + SRC_p	V(194) = K(194,1) * [SRC_p \|PROM1];
R195	CTNNB1 + SRC_p	SRC_p \|CTNNB1	CTNNB1 + SRC_p → SRC_p \|CTNNB1	V(195) = K(195,1) * [SRC_p] * [CTNNB1] -K(195,2) * [SRC_p \|CTNNB1];
R196	SRC_p \|CTNNB1	CTNNB1_p + SRC_p	SRC_p \|CTNNB1 → CTNNB1_p + SRC_p	V(196) = K(196,1) * [SRC_p \|CTNNB1];
R197	MAPK1 + SGK1	SGK1 \|MAPK1	MAPK1 + SGK1 → SGK1 \|MAPK1	V(197) = K(197,1) * [SGK1] * [MAPK1] -K(197,2) * [SGK1 \|MAPK1];
R198	SGK1 \|MAPK1	MAPK1_p + SGK1	SGK1 \|MAPK1 → MAPK1_p + SGK1	V(198) = K(198,1) * [SGK1 \|MAPK1];
R199	DDIT3 + PRKAA1_p	PRKAA1_p \|DDIT3	DDIT3 + PRKAA1_p → PRKAA1_p \|DDIT3	V(199) = K(199,1) * [PRKAA1_p] * [DDIT3] -K(199,2) * [PRKAA1_p \|DDIT3];