Interstitial Cell A (in cortex)_Parametric ODE Equations

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Reaction ID	Reactants	Products	Original Text	ODE Equations
R1	SMAD2_p + SMAD4_p	SIGNOR-C8	SMAD2_p + SMAD4_p → SIGNOR-C8	V(1) = K(1,1) * [SMAD2_p] * [SMAD4_p] -K(1,2) * [SIGNOR-C8];
R2	JUN_p + SMAD4_p	SIGNOR-C10	JUN_p + SMAD4_p → SIGNOR-C10	V(2) = K(2,1) * [SMAD4_p] * [JUN_p] -K(2,2) * [SIGNOR-C10];
R3	NR3C1_p + STAT5A_p	SIGNOR-C84	NR3C1_p + STAT5A_p → SIGNOR-C84	V(3) = K(3,1) * [NR3C1_p] * [STAT5A_p] -K(3,2) * [SIGNOR-C84];
R4	SMAD1 + SMAD1 + SMAD4_p	SIGNOR-C85	SMAD1 + SMAD1 + SMAD4_p → SIGNOR-C85	V(4) = K(4,1) * [SMAD4_p] * [SMAD1] * [SMAD1] -K(4,2) * [SIGNOR-C85];
R5	FOS_p + FOS_p + FOS_p + FOS_p + JUN_p + JUN_p + JUN_p + JUN_p	SIGNOR-C154	FOS_p + FOS_p + FOS_p + FOS_p + JUN_p + JUN_p + JUN_p + JUN_p → SIGNOR-C154	V(5) = K(5,1) * [FOS_p] * [JUN_p] * [JUN_p] * [FOS_p] * [JUN_p] * [FOS_p] * [FOS_p] * [JUN_p] -K(5,2) * [SIGNOR-C154];
R6	HIF1A + MAPK1_p	MAPK1_p \|HIF1A	HIF1A + MAPK1_p → MAPK1_p \|HIF1A	V(6) = K(6,1) * [MAPK1_p] * [HIF1A] -K(6,2) * [MAPK1_p \|HIF1A];
R7	MAPK1_p \|HIF1A	HIF1A_p + MAPK1_p	MAPK1_p \|HIF1A → HIF1A_p + MAPK1_p	V(7) = K(7,1) * [MAPK1_p \|HIF1A];
R8	MAPK1_p + NR3C1	MAPK1_p \|NR3C1	MAPK1_p + NR3C1 → MAPK1_p \|NR3C1	V(8) = K(8,1) * [MAPK1_p] * [NR3C1] -K(8,2) * [MAPK1_p \|NR3C1];
R9	MAPK1_p \|NR3C1	MAPK1_p + NR3C1_p	MAPK1_p \|NR3C1 → MAPK1_p + NR3C1_p	V(9) = K(9,1) * [MAPK1_p \|NR3C1];
R10	MAPK1_p + RPS6KA3	MAPK1_p \|RPS6KA3	MAPK1_p + RPS6KA3 → MAPK1_p \|RPS6KA3	V(10) = K(10,1) * [MAPK1_p] * [RPS6KA3] -K(10,2) * [MAPK1_p \|RPS6KA3];
R11	MAPK1_p \|RPS6KA3	MAPK1_p + RPS6KA3_p	MAPK1_p \|RPS6KA3 → MAPK1_p + RPS6KA3_p	V(11) = K(11,1) * [MAPK1_p \|RPS6KA3];
R12	RPS6KA3 + SRC_p	SRC_p \|RPS6KA3	RPS6KA3 + SRC_p → SRC_p \|RPS6KA3	V(12) = K(12,1) * [SRC_p] * [RPS6KA3] -K(12,2) * [SRC_p \|RPS6KA3];
R13	SRC_p \|RPS6KA3	RPS6KA3_p + SRC_p	SRC_p \|RPS6KA3 → RPS6KA3_p + SRC_p	V(13) = K(13,1) * [SRC_p \|RPS6KA3];
R14	MAPK1_p + SMAD1	MAPK1_p \|SMAD1	MAPK1_p + SMAD1 → MAPK1_p \|SMAD1	V(14) = K(14,1) * [MAPK1_p] * [SMAD1] -K(14,2) * [MAPK1_p \|SMAD1];
R15	MAPK1_p \|SMAD1	MAPK1_p + SMAD1_p	MAPK1_p \|SMAD1 → MAPK1_p + SMAD1_p	V(15) = K(15,1) * [MAPK1_p \|SMAD1];
R16	KIT_p + PTPN11	KIT_p \|PTPN11	KIT_p + PTPN11 → KIT_p \|PTPN11	V(16) = K(16,1) * [KIT_p] * [PTPN11] -K(16,2) * [KIT_p \|PTPN11];
R17	KIT_p \|PTPN11	KIT_p + PTPN11_p	KIT_p \|PTPN11 → KIT_p + PTPN11_p	V(17) = K(17,1) * [KIT_p \|PTPN11];
R18	JAK2_p + STAT5A	JAK2_p \|STAT5A	JAK2_p + STAT5A → JAK2_p \|STAT5A	V(18) = K(18,1) * [JAK2_p] * [STAT5A] -K(18,2) * [JAK2_p \|STAT5A];
R19	JAK2_p \|STAT5A	JAK2_p + STAT5A_p	JAK2_p \|STAT5A → JAK2_p + STAT5A_p	V(19) = K(19,1) * [JAK2_p \|STAT5A];
R20	MAPK1_p + RPS6KB1	MAPK1_p \|RPS6KB1	MAPK1_p + RPS6KB1 → MAPK1_p \|RPS6KB1	V(20) = K(20,1) * [MAPK1_p] * [RPS6KB1] -K(20,2) * [MAPK1_p \|RPS6KB1];
R21	MAPK1_p \|RPS6KB1	MAPK1_p + RPS6KB1_p	MAPK1_p \|RPS6KB1 → MAPK1_p + RPS6KB1_p	V(21) = K(21,1) * [MAPK1_p \|RPS6KB1];
R22	IGF1R_p + IRS1	IGF1R_p \|IRS1	IGF1R_p + IRS1 → IGF1R_p \|IRS1	V(22) = K(22,1) * [IGF1R_p] * [IRS1] -K(22,2) * [IGF1R_p \|IRS1];
R23	IGF1R_p \|IRS1	IGF1R_p + IRS1_p	IGF1R_p \|IRS1 → IGF1R_p + IRS1_p	V(23) = K(23,1) * [IGF1R_p \|IRS1];
R24	SRC_p + TP53	SRC_p \|TP53	SRC_p + TP53 → SRC_p \|TP53	V(24) = K(24,1) * [SRC_p] * [TP53] -K(24,2) * [SRC_p \|TP53];
R25	SRC_p \|TP53	SRC_p + TP53_p	SRC_p \|TP53 → SRC_p + TP53_p	V(25) = K(25,1) * [SRC_p \|TP53];
R26	EGFR + EGFR_p	EGFR_p \|EGFR	EGFR + EGFR_p → EGFR_p \|EGFR	V(26) = K(26,1) * [EGFR_p] * [EGFR] -K(26,2) * [EGFR_p \|EGFR];
R27	EGFR_p \|EGFR	EGFR_p + EGFR_p	EGFR_p \|EGFR → EGFR_p + EGFR_p	V(27) = K(27,1) * [EGFR_p \|EGFR];
R28	JAK2 + JAK2_p	JAK2_p \|JAK2	JAK2 + JAK2_p → JAK2_p \|JAK2	V(28) = K(28,1) * [JAK2_p] * [JAK2] -K(28,2) * [JAK2_p \|JAK2];
R29	JAK2_p \|JAK2	JAK2_p + JAK2_p	JAK2_p \|JAK2 → JAK2_p + JAK2_p	V(29) = K(29,1) * [JAK2_p \|JAK2];
R30	CDKN1B + MAPK1_p	MAPK1_p \|CDKN1B	CDKN1B + MAPK1_p → MAPK1_p \|CDKN1B	V(30) = K(30,1) * [MAPK1_p] * [CDKN1B] -K(30,2) * [MAPK1_p \|CDKN1B];
R31	MAPK1_p \|CDKN1B	CDKN1B_p + MAPK1_p	MAPK1_p \|CDKN1B → CDKN1B_p + MAPK1_p	V(31) = K(31,1) * [MAPK1_p \|CDKN1B];
R32	MAPK1_p + SMAD4	MAPK1_p \|SMAD4	MAPK1_p + SMAD4 → MAPK1_p \|SMAD4	V(32) = K(32,1) * [MAPK1_p] * [SMAD4] -K(32,2) * [MAPK1_p \|SMAD4];
R33	MAPK1_p \|SMAD4	MAPK1_p + SMAD4_p	MAPK1_p \|SMAD4 → MAPK1_p + SMAD4_p	V(33) = K(33,1) * [MAPK1_p \|SMAD4];
R34	IRS1 + RPS6KB1_p	RPS6KB1_p \|IRS1	IRS1 + RPS6KB1_p → RPS6KB1_p \|IRS1	V(34) = K(34,1) * [RPS6KB1_p] * [IRS1] -K(34,2) * [RPS6KB1_p \|IRS1];
R35	RPS6KB1_p \|IRS1	IRS1_p + RPS6KB1_p	RPS6KB1_p \|IRS1 → IRS1_p + RPS6KB1_p	V(35) = K(35,1) * [RPS6KB1_p \|IRS1];
R36	PDPK1_p + RPS6KB1	PDPK1_p \|RPS6KB1	PDPK1_p + RPS6KB1 → PDPK1_p \|RPS6KB1	V(36) = K(36,1) * [PDPK1_p] * [RPS6KB1] -K(36,2) * [PDPK1_p \|RPS6KB1];
R37	PDPK1_p \|RPS6KB1	PDPK1_p + RPS6KB1_p	PDPK1_p \|RPS6KB1 → PDPK1_p + RPS6KB1_p	V(37) = K(37,1) * [PDPK1_p \|RPS6KB1];
R38	JUN + MAPK1_p	MAPK1_p \|JUN	JUN + MAPK1_p → MAPK1_p \|JUN	V(38) = K(38,1) * [MAPK1_p] * [JUN] -K(38,2) * [MAPK1_p \|JUN];
R39	MAPK1_p \|JUN	JUN_p + MAPK1_p	MAPK1_p \|JUN → JUN_p + MAPK1_p	V(39) = K(39,1) * [MAPK1_p \|JUN];
R40	JAK2_p + MAP3K5	JAK2_p \|MAP3K5	JAK2_p + MAP3K5 → JAK2_p \|MAP3K5	V(40) = K(40,1) * [JAK2_p] * [MAP3K5] -K(40,2) * [JAK2_p \|MAP3K5];
R41	JAK2_p \|MAP3K5	JAK2_p + MAP3K5_p	JAK2_p \|MAP3K5 → JAK2_p + MAP3K5_p	V(41) = K(41,1) * [JAK2_p \|MAP3K5];
R42	FOS + MAPK1_p	MAPK1_p \|FOS	FOS + MAPK1_p → MAPK1_p \|FOS	V(42) = K(42,1) * [MAPK1_p] * [FOS] -K(42,2) * [MAPK1_p \|FOS];
R43	MAPK1_p \|FOS	FOS_p + MAPK1_p	MAPK1_p \|FOS → FOS_p + MAPK1_p	V(43) = K(43,1) * [MAPK1_p \|FOS];
R44	SRC + SRC_p	SRC_p \|SRC	SRC + SRC_p → SRC_p \|SRC	V(44) = K(44,1) * [SRC_p] * [SRC] -K(44,2) * [SRC_p \|SRC];
R45	SRC_p \|SRC	SRC_p + SRC_p	SRC_p \|SRC → SRC_p + SRC_p	V(45) = K(45,1) * [SRC_p \|SRC];
R46	SRC_p + TLR3	SRC_p \|TLR3	SRC_p + TLR3 → SRC_p \|TLR3	V(46) = K(46,1) * [SRC_p] * [TLR3] -K(46,2) * [SRC_p \|TLR3];
R47	SRC_p \|TLR3	SRC_p + TLR3_p	SRC_p \|TLR3 → SRC_p + TLR3_p	V(47) = K(47,1) * [SRC_p \|TLR3];
R48	MAPK1_p + SMAD2	MAPK1_p \|SMAD2	MAPK1_p + SMAD2 → MAPK1_p \|SMAD2	V(48) = K(48,1) * [MAPK1_p] * [SMAD2] -K(48,2) * [MAPK1_p \|SMAD2];
R49	MAPK1_p \|SMAD2	MAPK1_p + SMAD2_p	MAPK1_p \|SMAD2 → MAPK1_p + SMAD2_p	V(49) = K(49,1) * [MAPK1_p \|SMAD2];
R50	CTNNB1 + KIT_p	KIT_p \|CTNNB1	CTNNB1 + KIT_p → KIT_p \|CTNNB1	V(50) = K(50,1) * [KIT_p] * [CTNNB1] -K(50,2) * [KIT_p \|CTNNB1];
R51	KIT_p \|CTNNB1	CTNNB1_p + KIT_p	KIT_p \|CTNNB1 → CTNNB1_p + KIT_p	V(51) = K(51,1) * [KIT_p \|CTNNB1];
R52	MAPK1_p + RORA	MAPK1_p \|RORA	MAPK1_p + RORA → MAPK1_p \|RORA	V(52) = K(52,1) * [MAPK1_p] * [RORA] -K(52,2) * [MAPK1_p \|RORA];
R53	MAPK1_p \|RORA	MAPK1_p + RORA_p	MAPK1_p \|RORA → MAPK1_p + RORA_p	V(53) = K(53,1) * [MAPK1_p \|RORA];
R54	BCL2 + MAPK1_p	MAPK1_p \|BCL2	BCL2 + MAPK1_p → MAPK1_p \|BCL2	V(54) = K(54,1) * [MAPK1_p] * [BCL2] -K(54,2) * [MAPK1_p \|BCL2];
R55	MAPK1_p \|BCL2	BCL2_p + MAPK1_p	MAPK1_p \|BCL2 → BCL2_p + MAPK1_p	V(55) = K(55,1) * [MAPK1_p \|BCL2];
R56	INSR + INSR_p	INSR_p \|INSR	INSR + INSR_p → INSR_p \|INSR	V(56) = K(56,1) * [INSR_p] * [INSR] -K(56,2) * [INSR_p \|INSR];
R57	INSR_p \|INSR	INSR_p + INSR_p	INSR_p \|INSR → INSR_p + INSR_p	V(57) = K(57,1) * [INSR_p \|INSR];
R58	INSR_p + IRS1	INSR_p \|IRS1	INSR_p + IRS1 → INSR_p \|IRS1	V(58) = K(58,1) * [INSR_p] * [IRS1] -K(58,2) * [INSR_p \|IRS1];
R59	INSR_p \|IRS1	INSR_p + IRS1_p	INSR_p \|IRS1 → INSR_p + IRS1_p	V(59) = K(59,1) * [INSR_p \|IRS1];
R60	DUSP1 + MAPK1_p	MAPK1_p \|DUSP1	DUSP1 + MAPK1_p → MAPK1_p \|DUSP1	V(60) = K(60,1) * [MAPK1_p] * [DUSP1] -K(60,2) * [MAPK1_p \|DUSP1];
R61	MAPK1_p \|DUSP1	DUSP1_p + MAPK1_p	MAPK1_p \|DUSP1 → DUSP1_p + MAPK1_p	V(61) = K(61,1) * [MAPK1_p \|DUSP1];
R62	MAPK1_p + NR3C2	MAPK1_p \|NR3C2	MAPK1_p + NR3C2 → MAPK1_p \|NR3C2	V(62) = K(62,1) * [MAPK1_p] * [NR3C2] -K(62,2) * [MAPK1_p \|NR3C2];
R63	MAPK1_p \|NR3C2	MAPK1_p + NR3C2_p	MAPK1_p \|NR3C2 → MAPK1_p + NR3C2_p	V(63) = K(63,1) * [MAPK1_p \|NR3C2];
R64	PKN1 + PKN1_p	PKN1_p \|PKN1	PKN1 + PKN1_p → PKN1_p \|PKN1	V(64) = K(64,1) * [PKN1_p] * [PKN1] -K(64,2) * [PKN1_p \|PKN1];
R65	PKN1_p \|PKN1	PKN1_p + PKN1_p	PKN1_p \|PKN1 → PKN1_p + PKN1_p	V(65) = K(65,1) * [PKN1_p \|PKN1];
R66	HSPB1 + RPS6KB1_p	RPS6KB1_p \|HSPB1	HSPB1 + RPS6KB1_p → RPS6KB1_p \|HSPB1	V(66) = K(66,1) * [RPS6KB1_p] * [HSPB1] -K(66,2) * [RPS6KB1_p \|HSPB1];
R67	RPS6KB1_p \|HSPB1	HSPB1_p + RPS6KB1_p	RPS6KB1_p \|HSPB1 → HSPB1_p + RPS6KB1_p	V(67) = K(67,1) * [RPS6KB1_p \|HSPB1];
R68	MAPK7 + MAPK7_p	MAPK7_p \|MAPK7	MAPK7 + MAPK7_p → MAPK7_p \|MAPK7	V(68) = K(68,1) * [MAPK7_p] * [MAPK7] -K(68,2) * [MAPK7_p \|MAPK7];
R69	MAPK7_p \|MAPK7	MAPK7_p + MAPK7_p	MAPK7_p \|MAPK7 → MAPK7_p + MAPK7_p	V(69) = K(69,1) * [MAPK7_p \|MAPK7];
R70	KIT + KIT_p	KIT_p \|KIT	KIT + KIT_p → KIT_p \|KIT	V(70) = K(70,1) * [KIT_p] * [KIT] -K(70,2) * [KIT_p \|KIT];
R71	KIT_p \|KIT	KIT_p + KIT_p	KIT_p \|KIT → KIT_p + KIT_p	V(71) = K(71,1) * [KIT_p \|KIT];
R72	FOXO1 + MAPK1_p	MAPK1_p \|FOXO1	FOXO1 + MAPK1_p → MAPK1_p \|FOXO1	V(72) = K(72,1) * [MAPK1_p] * [FOXO1] -K(72,2) * [MAPK1_p \|FOXO1];
R73	MAPK1_p \|FOXO1	FOXO1_p + MAPK1_p	MAPK1_p \|FOXO1 → FOXO1_p + MAPK1_p	V(73) = K(73,1) * [MAPK1_p \|FOXO1];
R74	ATR + PARP1	ATR \|PARP1	ATR + PARP1 → ATR \|PARP1	V(74) = K(74,1) * [ATR] * [PARP1] -K(74,2) * [ATR \|PARP1];
R75	ATR \|PARP1	ATR + PARP1_p	ATR \|PARP1 → ATR + PARP1_p	V(75) = K(75,1) * [ATR \|PARP1];
R76	JAK2_p + STAT1	JAK2_p \|STAT1	JAK2_p + STAT1 → JAK2_p \|STAT1	V(76) = K(76,1) * [JAK2_p] * [STAT1] -K(76,2) * [JAK2_p \|STAT1];
R77	JAK2_p \|STAT1	JAK2_p + STAT1_p	JAK2_p \|STAT1 → JAK2_p + STAT1_p	V(77) = K(77,1) * [JAK2_p \|STAT1];
R78	EGFR + SRC_p	SRC_p \|EGFR	EGFR + SRC_p → SRC_p \|EGFR	V(78) = K(78,1) * [SRC_p] * [EGFR] -K(78,2) * [SRC_p \|EGFR];
R79	SRC_p \|EGFR	EGFR_p + SRC_p	SRC_p \|EGFR → EGFR_p + SRC_p	V(79) = K(79,1) * [SRC_p \|EGFR];
R80	SRC_p + STAT1	SRC_p \|STAT1	SRC_p + STAT1 → SRC_p \|STAT1	V(80) = K(80,1) * [SRC_p] * [STAT1] -K(80,2) * [SRC_p \|STAT1];
R81	SRC_p \|STAT1	SRC_p + STAT1_p	SRC_p \|STAT1 → SRC_p + STAT1_p	V(81) = K(81,1) * [SRC_p \|STAT1];
R82	PDPK1_p + SGK1	PDPK1_p \|SGK1	PDPK1_p + SGK1 → PDPK1_p \|SGK1	V(82) = K(82,1) * [PDPK1_p] * [SGK1] -K(82,2) * [PDPK1_p \|SGK1];
R83	PDPK1_p \|SGK1	PDPK1_p + SGK1_p	PDPK1_p \|SGK1 → PDPK1_p + SGK1_p	V(83) = K(83,1) * [PDPK1_p \|SGK1];
R84	ERN1 + ERN1_p	ERN1_p \|ERN1	ERN1 + ERN1_p → ERN1_p \|ERN1	V(84) = K(84,1) * [ERN1_p] * [ERN1] -K(84,2) * [ERN1_p \|ERN1];
R85	ERN1_p \|ERN1	ERN1_p + ERN1_p	ERN1_p \|ERN1 → ERN1_p + ERN1_p	V(85) = K(85,1) * [ERN1_p \|ERN1];
R86	SRC_p + TRAF6	SRC_p \|TRAF6	SRC_p + TRAF6 → SRC_p \|TRAF6	V(86) = K(86,1) * [SRC_p] * [TRAF6] -K(86,2) * [SRC_p \|TRAF6];
R87	SRC_p \|TRAF6	SRC_p + TRAF6_p	SRC_p \|TRAF6 → SRC_p + TRAF6_p	V(87) = K(87,1) * [SRC_p \|TRAF6];
R88	MAP3K5 + RPS6KA3_p	RPS6KA3_p \|MAP3K5	MAP3K5 + RPS6KA3_p → RPS6KA3_p \|MAP3K5	V(88) = K(88,1) * [RPS6KA3_p] * [MAP3K5] -K(88,2) * [RPS6KA3_p \|MAP3K5];
R89	RPS6KA3_p \|MAP3K5	MAP3K5_p + RPS6KA3_p	RPS6KA3_p \|MAP3K5 → MAP3K5_p + RPS6KA3_p	V(89) = K(89,1) * [RPS6KA3_p \|MAP3K5];
R90	IGF1R + SRC_p	SRC_p \|IGF1R	IGF1R + SRC_p → SRC_p \|IGF1R	V(90) = K(90,1) * [SRC_p] * [IGF1R] -K(90,2) * [SRC_p \|IGF1R];
R91	SRC_p \|IGF1R	IGF1R_p + SRC_p	SRC_p \|IGF1R → IGF1R_p + SRC_p	V(91) = K(91,1) * [SRC_p \|IGF1R];
R92	MAPK1_p + SIGNOR-C154	MAPK1_p \|SIGNOR-C154	MAPK1_p + SIGNOR-C154 → MAPK1_p \|SIGNOR-C154	V(92) = K(92,1) * [MAPK1_p] * [SIGNOR-C154] -K(92,2) * [MAPK1_p \|SIGNOR-C154];
R93	MAPK1_p \|SIGNOR-C154	MAPK1_p + SIGNOR-C154_p	MAPK1_p \|SIGNOR-C154 → MAPK1_p + SIGNOR-C154_p	V(93) = K(93,1) * [MAPK1_p \|SIGNOR-C154];
R94	PINK1 + UBC	PINK1 \|UBC	PINK1 + UBC → PINK1 \|UBC	V(94) = K(94,1) * [PINK1] * [UBC] -K(94,2) * [PINK1 \|UBC];
R95	PINK1 \|UBC	PINK1 + UBC_p	PINK1 \|UBC → PINK1 + UBC_p	V(95) = K(95,1) * [PINK1 \|UBC];
R96	IGF1R + IGF1R_p	IGF1R_p \|IGF1R	IGF1R + IGF1R_p → IGF1R_p \|IGF1R	V(96) = K(96,1) * [IGF1R_p] * [IGF1R] -K(96,2) * [IGF1R_p \|IGF1R];
R97	IGF1R_p \|IGF1R	IGF1R_p + IGF1R_p	IGF1R_p \|IGF1R → IGF1R_p + IGF1R_p	V(97) = K(97,1) * [IGF1R_p \|IGF1R];
R98	FOXO1 + SGK1_p	SGK1_p \|FOXO1	FOXO1 + SGK1_p → SGK1_p \|FOXO1	V(98) = K(98,1) * [SGK1_p] * [FOXO1] -K(98,2) * [SGK1_p \|FOXO1];
R99	SGK1_p \|FOXO1	FOXO1_p + SGK1_p	SGK1_p \|FOXO1 → FOXO1_p + SGK1_p	V(99) = K(99,1) * [SGK1_p \|FOXO1];
R100	HIPK2 + HIPK2_p	HIPK2_p \|HIPK2	HIPK2 + HIPK2_p → HIPK2_p \|HIPK2	V(100) = K(100,1) * [HIPK2_p] * [HIPK2] -K(100,2) * [HIPK2_p \|HIPK2];
R101	HIPK2_p \|HIPK2	HIPK2_p + HIPK2_p	HIPK2_p \|HIPK2 → HIPK2_p + HIPK2_p	V(101) = K(101,1) * [HIPK2_p \|HIPK2];
R102	PDPK1 + PDPK1_p	PDPK1_p \|PDPK1	PDPK1 + PDPK1_p → PDPK1_p \|PDPK1	V(102) = K(102,1) * [PDPK1_p] * [PDPK1] -K(102,2) * [PDPK1_p \|PDPK1];
R103	PDPK1_p \|PDPK1	PDPK1_p + PDPK1_p	PDPK1_p \|PDPK1 → PDPK1_p + PDPK1_p	V(103) = K(103,1) * [PDPK1_p \|PDPK1];
R104	CDKN1B + SGK1_p	SGK1_p \|CDKN1B	CDKN1B + SGK1_p → SGK1_p \|CDKN1B	V(104) = K(104,1) * [SGK1_p] * [CDKN1B] -K(104,2) * [SGK1_p \|CDKN1B];
R105	SGK1_p \|CDKN1B	CDKN1B_p + SGK1_p	SGK1_p \|CDKN1B → CDKN1B_p + SGK1_p	V(105) = K(105,1) * [SGK1_p \|CDKN1B];
R106	CREB1 + RPS6KA3_p	RPS6KA3_p \|CREB1	CREB1 + RPS6KA3_p → RPS6KA3_p \|CREB1	V(106) = K(106,1) * [RPS6KA3_p] * [CREB1] -K(106,2) * [RPS6KA3_p \|CREB1];
R107	RPS6KA3_p \|CREB1	CREB1_p + RPS6KA3_p	RPS6KA3_p \|CREB1 → CREB1_p + RPS6KA3_p	V(107) = K(107,1) * [RPS6KA3_p \|CREB1];
R108	PDPK1 + SRC_p	SRC_p \|PDPK1	PDPK1 + SRC_p → SRC_p \|PDPK1	V(108) = K(108,1) * [SRC_p] * [PDPK1] -K(108,2) * [SRC_p \|PDPK1];
R109	SRC_p \|PDPK1	PDPK1_p + SRC_p	SRC_p \|PDPK1 → PDPK1_p + SRC_p	V(109) = K(109,1) * [SRC_p \|PDPK1];
R110	EGFR + MAPK1_p	MAPK1_p \|EGFR	EGFR + MAPK1_p → MAPK1_p \|EGFR	V(110) = K(110,1) * [MAPK1_p] * [EGFR] -K(110,2) * [MAPK1_p \|EGFR];
R111	MAPK1_p \|EGFR	EGFR_p + MAPK1_p	MAPK1_p \|EGFR → EGFR_p + MAPK1_p	V(111) = K(111,1) * [MAPK1_p \|EGFR];
R112	PTEN + SRC_p	SRC_p \|PTEN	PTEN + SRC_p → SRC_p \|PTEN	V(112) = K(112,1) * [SRC_p] * [PTEN] -K(112,2) * [SRC_p \|PTEN];
R113	SRC_p \|PTEN	PTEN_p + SRC_p	SRC_p \|PTEN → PTEN_p + SRC_p	V(113) = K(113,1) * [SRC_p \|PTEN];
R114	MAP3K5 + MAP3K5_p	MAP3K5_p \|MAP3K5	MAP3K5 + MAP3K5_p → MAP3K5_p \|MAP3K5	V(114) = K(114,1) * [MAP3K5_p] * [MAP3K5] -K(114,2) * [MAP3K5_p \|MAP3K5];
R115	MAP3K5_p \|MAP3K5	MAP3K5_p + MAP3K5_p	MAP3K5_p \|MAP3K5 → MAP3K5_p + MAP3K5_p	V(115) = K(115,1) * [MAP3K5_p \|MAP3K5];
R116	DNMT1 + PRKAA1	PRKAA1 \|DNMT1	DNMT1 + PRKAA1 → PRKAA1 \|DNMT1	V(116) = K(116,1) * [PRKAA1] * [DNMT1] -K(116,2) * [PRKAA1 \|DNMT1];
R117	PRKAA1 \|DNMT1	DNMT1_p + PRKAA1	PRKAA1 \|DNMT1 → DNMT1_p + PRKAA1	V(117) = K(117,1) * [PRKAA1 \|DNMT1];
R118	MAPK1_p + SP1	MAPK1_p \|SP1	MAPK1_p + SP1 → MAPK1_p \|SP1	V(118) = K(118,1) * [MAPK1_p] * [SP1] -K(118,2) * [MAPK1_p \|SP1];
R119	MAPK1_p \|SP1	MAPK1_p + SP1_p	MAPK1_p \|SP1 → MAPK1_p + SP1_p	V(119) = K(119,1) * [MAPK1_p \|SP1];
R120	PTEN + ROCK1	ROCK1 \|PTEN	PTEN + ROCK1 → ROCK1 \|PTEN	V(120) = K(120,1) * [ROCK1] * [PTEN] -K(120,2) * [ROCK1 \|PTEN];
R121	ROCK1 \|PTEN	PTEN_p + ROCK1	ROCK1 \|PTEN → PTEN_p + ROCK1	V(121) = K(121,1) * [ROCK1 \|PTEN];
R122	MAPK1_p + STAT5A	MAPK1_p \|STAT5A	MAPK1_p + STAT5A → MAPK1_p \|STAT5A	V(122) = K(122,1) * [MAPK1_p] * [STAT5A] -K(122,2) * [MAPK1_p \|STAT5A];
R123	MAPK1_p \|STAT5A	MAPK1_p + STAT5A_p	MAPK1_p \|STAT5A → MAPK1_p + STAT5A_p	V(123) = K(123,1) * [MAPK1_p \|STAT5A];
R124	ANXA1 + SRC_p	SRC_p \|ANXA1	ANXA1 + SRC_p → SRC_p \|ANXA1	V(124) = K(124,1) * [SRC_p] * [ANXA1] -K(124,2) * [SRC_p \|ANXA1];
R125	SRC_p \|ANXA1	ANXA1_p + SRC_p	SRC_p \|ANXA1 → ANXA1_p + SRC_p	V(125) = K(125,1) * [SRC_p \|ANXA1];
R126	PDPK1_p + RPS6KA3	PDPK1_p \|RPS6KA3	PDPK1_p + RPS6KA3 → PDPK1_p \|RPS6KA3	V(126) = K(126,1) * [PDPK1_p] * [RPS6KA3] -K(126,2) * [PDPK1_p \|RPS6KA3];
R127	PDPK1_p \|RPS6KA3	PDPK1_p + RPS6KA3_p	PDPK1_p \|RPS6KA3 → PDPK1_p + RPS6KA3_p	V(127) = K(127,1) * [PDPK1_p \|RPS6KA3];
R128	PTPRJ + SRC_p	SRC_p \|PTPRJ	PTPRJ + SRC_p → SRC_p \|PTPRJ	V(128) = K(128,1) * [SRC_p] * [PTPRJ] -K(128,2) * [SRC_p \|PTPRJ];
R129	SRC_p \|PTPRJ	PTPRJ_p + SRC_p	SRC_p \|PTPRJ → PTPRJ_p + SRC_p	V(129) = K(129,1) * [SRC_p \|PTPRJ];
R130	CDKN1A + MAPK1_p	MAPK1_p \|CDKN1A	CDKN1A + MAPK1_p → MAPK1_p \|CDKN1A	V(130) = K(130,1) * [MAPK1_p] * [CDKN1A] -K(130,2) * [MAPK1_p \|CDKN1A];
R131	MAPK1_p \|CDKN1A	CDKN1A_p + MAPK1_p	MAPK1_p \|CDKN1A → CDKN1A_p + MAPK1_p	V(131) = K(131,1) * [MAPK1_p \|CDKN1A];
R132	FOXO1 + PRKAA1	PRKAA1 \|FOXO1	FOXO1 + PRKAA1 → PRKAA1 \|FOXO1	V(132) = K(132,1) * [PRKAA1] * [FOXO1] -K(132,2) * [PRKAA1 \|FOXO1];
R133	PRKAA1 \|FOXO1	FOXO1_p + PRKAA1	PRKAA1 \|FOXO1 → FOXO1_p + PRKAA1	V(133) = K(133,1) * [PRKAA1 \|FOXO1];
R134	JAK2 + MAPK1_p	MAPK1_p \|JAK2	JAK2 + MAPK1_p → MAPK1_p \|JAK2	V(134) = K(134,1) * [MAPK1_p] * [JAK2] -K(134,2) * [MAPK1_p \|JAK2];
R135	MAPK1_p \|JAK2	JAK2_p + MAPK1_p	MAPK1_p \|JAK2 → JAK2_p + MAPK1_p	V(135) = K(135,1) * [MAPK1_p \|JAK2];
R136	MAPK1_p + STIM1	MAPK1_p \|STIM1	MAPK1_p + STIM1 → MAPK1_p \|STIM1	V(136) = K(136,1) * [MAPK1_p] * [STIM1] -K(136,2) * [MAPK1_p \|STIM1];
R137	MAPK1_p \|STIM1	MAPK1_p + STIM1_p	MAPK1_p \|STIM1 → MAPK1_p + STIM1_p	V(137) = K(137,1) * [MAPK1_p \|STIM1];
R138	IGF1R_p + PCNA	IGF1R_p \|PCNA	IGF1R_p + PCNA → IGF1R_p \|PCNA	V(138) = K(138,1) * [IGF1R_p] * [PCNA] -K(138,2) * [IGF1R_p \|PCNA];
R139	IGF1R_p \|PCNA	IGF1R_p + PCNA_p	IGF1R_p \|PCNA → IGF1R_p + PCNA_p	V(139) = K(139,1) * [IGF1R_p \|PCNA];
R140	IGF1R_p + PDPK1	IGF1R_p \|PDPK1	IGF1R_p + PDPK1 → IGF1R_p \|PDPK1	V(140) = K(140,1) * [IGF1R_p] * [PDPK1] -K(140,2) * [IGF1R_p \|PDPK1];
R141	IGF1R_p \|PDPK1	IGF1R_p + PDPK1_p	IGF1R_p \|PDPK1 → IGF1R_p + PDPK1_p	V(141) = K(141,1) * [IGF1R_p \|PDPK1];
R142	MAPK1_p + PARP1	MAPK1_p \|PARP1	MAPK1_p + PARP1 → MAPK1_p \|PARP1	V(142) = K(142,1) * [MAPK1_p] * [PARP1] -K(142,2) * [MAPK1_p \|PARP1];
R143	MAPK1_p \|PARP1	MAPK1_p + PARP1_p	MAPK1_p \|PARP1 → MAPK1_p + PARP1_p	V(143) = K(143,1) * [MAPK1_p \|PARP1];
R144	CLTC + SRC_p	SRC_p \|CLTC	CLTC + SRC_p → SRC_p \|CLTC	V(144) = K(144,1) * [SRC_p] * [CLTC] -K(144,2) * [SRC_p \|CLTC];
R145	SRC_p \|CLTC	CLTC_p + SRC_p	SRC_p \|CLTC → CLTC_p + SRC_p	V(145) = K(145,1) * [SRC_p \|CLTC];
R146	JAK2_p + STAT6	JAK2_p \|STAT6	JAK2_p + STAT6 → JAK2_p \|STAT6	V(146) = K(146,1) * [JAK2_p] * [STAT6] -K(146,2) * [JAK2_p \|STAT6];
R147	JAK2_p \|STAT6	JAK2_p + STAT6_p	JAK2_p \|STAT6 → JAK2_p + STAT6_p	V(147) = K(147,1) * [JAK2_p \|STAT6];
R148	MAP3K14_p + NFKB2	MAP3K14_p \|NFKB2	MAP3K14_p + NFKB2 → MAP3K14_p \|NFKB2	V(148) = K(148,1) * [MAP3K14_p] * [NFKB2] -K(148,2) * [MAP3K14_p \|NFKB2];
R149	MAP3K14_p \|NFKB2	MAP3K14_p + NFKB2_p	MAP3K14_p \|NFKB2 → MAP3K14_p + NFKB2_p	V(149) = K(149,1) * [MAP3K14_p \|NFKB2];
R150	FOXO1 + PKN1_p	PKN1_p \|FOXO1	FOXO1 + PKN1_p → PKN1_p \|FOXO1	V(150) = K(150,1) * [PKN1_p] * [FOXO1] -K(150,2) * [PKN1_p \|FOXO1];
R151	PKN1_p \|FOXO1	FOXO1_p + PKN1_p	PKN1_p \|FOXO1 → FOXO1_p + PKN1_p	V(151) = K(151,1) * [PKN1_p \|FOXO1];
R152	CASP9 + MAPK1_p	MAPK1_p \|CASP9	CASP9 + MAPK1_p → MAPK1_p \|CASP9	V(152) = K(152,1) * [MAPK1_p] * [CASP9] -K(152,2) * [MAPK1_p \|CASP9];
R153	MAPK1_p \|CASP9	CASP9_p + MAPK1_p	MAPK1_p \|CASP9 → CASP9_p + MAPK1_p	V(153) = K(153,1) * [MAPK1_p \|CASP9];
R154	RICTOR + RPS6KB1_p	RPS6KB1_p \|RICTOR	RICTOR + RPS6KB1_p → RPS6KB1_p \|RICTOR	V(154) = K(154,1) * [RPS6KB1_p] * [RICTOR] -K(154,2) * [RPS6KB1_p \|RICTOR];
R155	RPS6KB1_p \|RICTOR	RICTOR_p + RPS6KB1_p	RPS6KB1_p \|RICTOR → RICTOR_p + RPS6KB1_p	V(155) = K(155,1) * [RPS6KB1_p \|RICTOR];
R156	MAP3K14 + MAP3K14_p	MAP3K14_p \|MAP3K14	MAP3K14 + MAP3K14_p → MAP3K14_p \|MAP3K14	V(156) = K(156,1) * [MAP3K14_p] * [MAP3K14] -K(156,2) * [MAP3K14_p \|MAP3K14];
R157	MAP3K14_p \|MAP3K14	MAP3K14_p + MAP3K14_p	MAP3K14_p \|MAP3K14 → MAP3K14_p + MAP3K14_p	V(157) = K(157,1) * [MAP3K14_p \|MAP3K14];
R158	IGF1R_p + IRS2	IGF1R_p \|IRS2	IGF1R_p + IRS2 → IGF1R_p \|IRS2	V(158) = K(158,1) * [IGF1R_p] * [IRS2] -K(158,2) * [IGF1R_p \|IRS2];
R159	IGF1R_p \|IRS2	IGF1R_p + IRS2_p	IGF1R_p \|IRS2 → IGF1R_p + IRS2_p	V(159) = K(159,1) * [IGF1R_p \|IRS2];
R160	CDKN1B + JAK2_p	JAK2_p \|CDKN1B	CDKN1B + JAK2_p → JAK2_p \|CDKN1B	V(160) = K(160,1) * [JAK2_p] * [CDKN1B] -K(160,2) * [JAK2_p \|CDKN1B];
R161	JAK2_p \|CDKN1B	CDKN1B_p + JAK2_p	JAK2_p \|CDKN1B → CDKN1B_p + JAK2_p	V(161) = K(161,1) * [JAK2_p \|CDKN1B];
R162	SMAD1 + SMAD4	SMAD1 \|SMAD4	SMAD1 + SMAD4 → SMAD1 \|SMAD4	V(162) = K(162,1) * [SMAD1] * [SMAD4] -K(162,2) * [SMAD1 \|SMAD4];
R163	SMAD1 \|SMAD4	SMAD1 + SMAD4_p	SMAD1 \|SMAD4 → SMAD1 + SMAD4_p	V(163) = K(163,1) * [SMAD1 \|SMAD4];
R164	FOS + RPS6KA3_p	RPS6KA3_p \|FOS	FOS + RPS6KA3_p → RPS6KA3_p \|FOS	V(164) = K(164,1) * [RPS6KA3_p] * [FOS] -K(164,2) * [RPS6KA3_p \|FOS];
R165	RPS6KA3_p \|FOS	FOS_p + RPS6KA3_p	RPS6KA3_p \|FOS → FOS_p + RPS6KA3_p	V(165) = K(165,1) * [RPS6KA3_p \|FOS];
R166	KIT_p + STAT1	KIT_p \|STAT1	KIT_p + STAT1 → KIT_p \|STAT1	V(166) = K(166,1) * [KIT_p] * [STAT1] -K(166,2) * [KIT_p \|STAT1];
R167	KIT_p \|STAT1	KIT_p + STAT1_p	KIT_p \|STAT1 → KIT_p + STAT1_p	V(167) = K(167,1) * [KIT_p \|STAT1];
R168	RPS6KA3 + RPS6KA3_p	RPS6KA3_p \|RPS6KA3	RPS6KA3 + RPS6KA3_p → RPS6KA3_p \|RPS6KA3	V(168) = K(168,1) * [RPS6KA3_p] * [RPS6KA3] -K(168,2) * [RPS6KA3_p \|RPS6KA3];
R169	RPS6KA3_p \|RPS6KA3	RPS6KA3_p + RPS6KA3_p	RPS6KA3_p \|RPS6KA3 → RPS6KA3_p + RPS6KA3_p	V(169) = K(169,1) * [RPS6KA3_p \|RPS6KA3];
R170	HDAC4 + PRKAA1	PRKAA1 \|HDAC4	HDAC4 + PRKAA1 → PRKAA1 \|HDAC4	V(170) = K(170,1) * [PRKAA1] * [HDAC4] -K(170,2) * [PRKAA1 \|HDAC4];
R171	PRKAA1 \|HDAC4	HDAC4_p + PRKAA1	PRKAA1 \|HDAC4 → HDAC4_p + PRKAA1	V(171) = K(171,1) * [PRKAA1 \|HDAC4];
R172	IRS1 + MAPK1_p	MAPK1_p \|IRS1	IRS1 + MAPK1_p → MAPK1_p \|IRS1	V(172) = K(172,1) * [MAPK1_p] * [IRS1] -K(172,2) * [MAPK1_p \|IRS1];
R173	MAPK1_p \|IRS1	IRS1_p + MAPK1_p	MAPK1_p \|IRS1 → IRS1_p + MAPK1_p	V(173) = K(173,1) * [MAPK1_p \|IRS1];
R174	NR4A1 + RPS6KA3_p	RPS6KA3_p \|NR4A1	NR4A1 + RPS6KA3_p → RPS6KA3_p \|NR4A1	V(174) = K(174,1) * [RPS6KA3_p] * [NR4A1] -K(174,2) * [RPS6KA3_p \|NR4A1];
R175	RPS6KA3_p \|NR4A1	NR4A1_p + RPS6KA3_p	RPS6KA3_p \|NR4A1 → NR4A1_p + RPS6KA3_p	V(175) = K(175,1) * [RPS6KA3_p \|NR4A1];
R176	ROCK1 + TP53	ROCK1 \|TP53	ROCK1 + TP53 → ROCK1 \|TP53	V(176) = K(176,1) * [ROCK1] * [TP53] -K(176,2) * [ROCK1 \|TP53];
R177	ROCK1 \|TP53	ROCK1 + TP53_p	ROCK1 \|TP53 → ROCK1 + TP53_p	V(177) = K(177,1) * [ROCK1 \|TP53];
R178	RAC1 + SRC_p	SRC_p \|RAC1	RAC1 + SRC_p → SRC_p \|RAC1	V(178) = K(178,1) * [SRC_p] * [RAC1] -K(178,2) * [SRC_p \|RAC1];
R179	SRC_p \|RAC1	RAC1_p + SRC_p	SRC_p \|RAC1 → RAC1_p + SRC_p	V(179) = K(179,1) * [SRC_p \|RAC1];
R180	MAPK1 + MAPK1_p	MAPK1_p \|MAPK1	MAPK1 + MAPK1_p → MAPK1_p \|MAPK1	V(180) = K(180,1) * [MAPK1_p] * [MAPK1] -K(180,2) * [MAPK1_p \|MAPK1];
R181	MAPK1_p \|MAPK1	MAPK1_p + MAPK1_p	MAPK1_p \|MAPK1 → MAPK1_p + MAPK1_p	V(181) = K(181,1) * [MAPK1_p \|MAPK1];
R182	MAPK1_p + RRAS	MAPK1_p \|RRAS	MAPK1_p + RRAS → MAPK1_p \|RRAS	V(182) = K(182,1) * [MAPK1_p] * [RRAS] -K(182,2) * [MAPK1_p \|RRAS];
R183	MAPK1_p \|RRAS	MAPK1_p + RRAS_p	MAPK1_p \|RRAS → MAPK1_p + RRAS_p	V(183) = K(183,1) * [MAPK1_p \|RRAS];
R184	CDH1 + SRC_p	SRC_p \|CDH1	CDH1 + SRC_p → SRC_p \|CDH1	V(184) = K(184,1) * [SRC_p] * [CDH1] -K(184,2) * [SRC_p \|CDH1];
R185	SRC_p \|CDH1	CDH1_p + SRC_p	SRC_p \|CDH1 → CDH1_p + SRC_p	V(185) = K(185,1) * [SRC_p \|CDH1];
R186	MAPK1_p + ZFP36	MAPK1_p \|ZFP36	MAPK1_p + ZFP36 → MAPK1_p \|ZFP36	V(186) = K(186,1) * [MAPK1_p] * [ZFP36] -K(186,2) * [MAPK1_p \|ZFP36];
R187	MAPK1_p \|ZFP36	MAPK1_p + ZFP36_p	MAPK1_p \|ZFP36 → MAPK1_p + ZFP36_p	V(187) = K(187,1) * [MAPK1_p \|ZFP36];
R188	MAPK1_p + RCAN1	MAPK1_p \|RCAN1	MAPK1_p + RCAN1 → MAPK1_p \|RCAN1	V(188) = K(188,1) * [MAPK1_p] * [RCAN1] -K(188,2) * [MAPK1_p \|RCAN1];
R189	MAPK1_p \|RCAN1	MAPK1_p + RCAN1_p	MAPK1_p \|RCAN1 → MAPK1_p + RCAN1_p	V(189) = K(189,1) * [MAPK1_p \|RCAN1];
R190	EGFR + JAK2_p	JAK2_p \|EGFR	EGFR + JAK2_p → JAK2_p \|EGFR	V(190) = K(190,1) * [JAK2_p] * [EGFR] -K(190,2) * [JAK2_p \|EGFR];
R191	JAK2_p \|EGFR	EGFR_p + JAK2_p	JAK2_p \|EGFR → EGFR_p + JAK2_p	V(191) = K(191,1) * [JAK2_p \|EGFR];
R192	EGFR + PKN1_p	PKN1_p \|EGFR	EGFR + PKN1_p → PKN1_p \|EGFR	V(192) = K(192,1) * [PKN1_p] * [EGFR] -K(192,2) * [PKN1_p \|EGFR];
R193	PKN1_p \|EGFR	EGFR_p + PKN1_p	PKN1_p \|EGFR → EGFR_p + PKN1_p	V(193) = K(193,1) * [PKN1_p \|EGFR];
R194	KIT + SRC_p	SRC_p \|KIT	KIT + SRC_p → SRC_p \|KIT	V(194) = K(194,1) * [SRC_p] * [KIT] -K(194,2) * [SRC_p \|KIT];
R195	SRC_p \|KIT	KIT_p + SRC_p	SRC_p \|KIT → KIT_p + SRC_p	V(195) = K(195,1) * [SRC_p \|KIT];
R196	SGK1_p + SP1	SGK1_p \|SP1	SGK1_p + SP1 → SGK1_p \|SP1	V(196) = K(196,1) * [SGK1_p] * [SP1] -K(196,2) * [SGK1_p \|SP1];
R197	SGK1_p \|SP1	SGK1_p + SP1_p	SGK1_p \|SP1 → SGK1_p + SP1_p	V(197) = K(197,1) * [SGK1_p \|SP1];
R198	HIPK2 + PRKAA1	PRKAA1 \|HIPK2	HIPK2 + PRKAA1 → PRKAA1 \|HIPK2	V(198) = K(198,1) * [PRKAA1] * [HIPK2] -K(198,2) * [PRKAA1 \|HIPK2];
R199	PRKAA1 \|HIPK2	HIPK2_p + PRKAA1	PRKAA1 \|HIPK2 → HIPK2_p + PRKAA1	V(199) = K(199,1) * [PRKAA1 \|HIPK2];

Reaction ID	Reactants	Products	Original Text	ODE Equations
R1	SMAD2_p + SMAD4_p	SIGNOR-C8	SMAD2_p + SMAD4_p → SIGNOR-C8	V(1) = K(1,1) * [SMAD2_p] * [SMAD4_p] -K(1,2) * [SIGNOR-C8];
R2	JUN_p + SMAD4_p	SIGNOR-C10	JUN_p + SMAD4_p → SIGNOR-C10	V(2) = K(2,1) * [SMAD4_p] * [JUN_p] -K(2,2) * [SIGNOR-C10];
R3	NR3C1_p + STAT5A_p	SIGNOR-C84	NR3C1_p + STAT5A_p → SIGNOR-C84	V(3) = K(3,1) * [NR3C1_p] * [STAT5A_p] -K(3,2) * [SIGNOR-C84];
R4	SMAD1 + SMAD1 + SMAD4_p	SIGNOR-C85	SMAD1 + SMAD1 + SMAD4_p → SIGNOR-C85	V(4) = K(4,1) * [SMAD4_p] * [SMAD1] * [SMAD1] -K(4,2) * [SIGNOR-C85];
R5	FOS_p + FOS_p + FOS_p + FOS_p + JUN_p + JUN_p + JUN_p + JUN_p	SIGNOR-C154	FOS_p + FOS_p + FOS_p + FOS_p + JUN_p + JUN_p + JUN_p + JUN_p → SIGNOR-C154	V(5) = K(5,1) * [FOS_p] * [JUN_p] * [JUN_p] * [FOS_p] * [JUN_p] * [FOS_p] * [FOS_p] * [JUN_p] -K(5,2) * [SIGNOR-C154];
R6	HIF1A + MAPK1_p	MAPK1_p \|HIF1A	HIF1A + MAPK1_p → MAPK1_p \|HIF1A	V(6) = K(6,1) * [MAPK1_p] * [HIF1A] -K(6,2) * [MAPK1_p \|HIF1A];
R7	MAPK1_p \|HIF1A	HIF1A_p + MAPK1_p	MAPK1_p \|HIF1A → HIF1A_p + MAPK1_p	V(7) = K(7,1) * [MAPK1_p \|HIF1A];
R8	MAPK1_p + NR3C1	MAPK1_p \|NR3C1	MAPK1_p + NR3C1 → MAPK1_p \|NR3C1	V(8) = K(8,1) * [MAPK1_p] * [NR3C1] -K(8,2) * [MAPK1_p \|NR3C1];
R9	MAPK1_p \|NR3C1	MAPK1_p + NR3C1_p	MAPK1_p \|NR3C1 → MAPK1_p + NR3C1_p	V(9) = K(9,1) * [MAPK1_p \|NR3C1];
R10	MAPK1_p + RPS6KA3	MAPK1_p \|RPS6KA3	MAPK1_p + RPS6KA3 → MAPK1_p \|RPS6KA3	V(10) = K(10,1) * [MAPK1_p] * [RPS6KA3] -K(10,2) * [MAPK1_p \|RPS6KA3];
R11	MAPK1_p \|RPS6KA3	MAPK1_p + RPS6KA3_p	MAPK1_p \|RPS6KA3 → MAPK1_p + RPS6KA3_p	V(11) = K(11,1) * [MAPK1_p \|RPS6KA3];
R12	RPS6KA3 + SRC_p	SRC_p \|RPS6KA3	RPS6KA3 + SRC_p → SRC_p \|RPS6KA3	V(12) = K(12,1) * [SRC_p] * [RPS6KA3] -K(12,2) * [SRC_p \|RPS6KA3];
R13	SRC_p \|RPS6KA3	RPS6KA3_p + SRC_p	SRC_p \|RPS6KA3 → RPS6KA3_p + SRC_p	V(13) = K(13,1) * [SRC_p \|RPS6KA3];
R14	MAPK1_p + SMAD1	MAPK1_p \|SMAD1	MAPK1_p + SMAD1 → MAPK1_p \|SMAD1	V(14) = K(14,1) * [MAPK1_p] * [SMAD1] -K(14,2) * [MAPK1_p \|SMAD1];
R15	MAPK1_p \|SMAD1	MAPK1_p + SMAD1_p	MAPK1_p \|SMAD1 → MAPK1_p + SMAD1_p	V(15) = K(15,1) * [MAPK1_p \|SMAD1];
R16	KIT_p + PTPN11	KIT_p \|PTPN11	KIT_p + PTPN11 → KIT_p \|PTPN11	V(16) = K(16,1) * [KIT_p] * [PTPN11] -K(16,2) * [KIT_p \|PTPN11];
R17	KIT_p \|PTPN11	KIT_p + PTPN11_p	KIT_p \|PTPN11 → KIT_p + PTPN11_p	V(17) = K(17,1) * [KIT_p \|PTPN11];
R18	JAK2_p + STAT5A	JAK2_p \|STAT5A	JAK2_p + STAT5A → JAK2_p \|STAT5A	V(18) = K(18,1) * [JAK2_p] * [STAT5A] -K(18,2) * [JAK2_p \|STAT5A];
R19	JAK2_p \|STAT5A	JAK2_p + STAT5A_p	JAK2_p \|STAT5A → JAK2_p + STAT5A_p	V(19) = K(19,1) * [JAK2_p \|STAT5A];
R20	MAPK1_p + RPS6KB1	MAPK1_p \|RPS6KB1	MAPK1_p + RPS6KB1 → MAPK1_p \|RPS6KB1	V(20) = K(20,1) * [MAPK1_p] * [RPS6KB1] -K(20,2) * [MAPK1_p \|RPS6KB1];
R21	MAPK1_p \|RPS6KB1	MAPK1_p + RPS6KB1_p	MAPK1_p \|RPS6KB1 → MAPK1_p + RPS6KB1_p	V(21) = K(21,1) * [MAPK1_p \|RPS6KB1];
R22	IGF1R_p + IRS1	IGF1R_p \|IRS1	IGF1R_p + IRS1 → IGF1R_p \|IRS1	V(22) = K(22,1) * [IGF1R_p] * [IRS1] -K(22,2) * [IGF1R_p \|IRS1];
R23	IGF1R_p \|IRS1	IGF1R_p + IRS1_p	IGF1R_p \|IRS1 → IGF1R_p + IRS1_p	V(23) = K(23,1) * [IGF1R_p \|IRS1];
R24	SRC_p + TP53	SRC_p \|TP53	SRC_p + TP53 → SRC_p \|TP53	V(24) = K(24,1) * [SRC_p] * [TP53] -K(24,2) * [SRC_p \|TP53];
R25	SRC_p \|TP53	SRC_p + TP53_p	SRC_p \|TP53 → SRC_p + TP53_p	V(25) = K(25,1) * [SRC_p \|TP53];
R26	EGFR + EGFR_p	EGFR_p \|EGFR	EGFR + EGFR_p → EGFR_p \|EGFR	V(26) = K(26,1) * [EGFR_p] * [EGFR] -K(26,2) * [EGFR_p \|EGFR];
R27	EGFR_p \|EGFR	EGFR_p + EGFR_p	EGFR_p \|EGFR → EGFR_p + EGFR_p	V(27) = K(27,1) * [EGFR_p \|EGFR];
R28	JAK2 + JAK2_p	JAK2_p \|JAK2	JAK2 + JAK2_p → JAK2_p \|JAK2	V(28) = K(28,1) * [JAK2_p] * [JAK2] -K(28,2) * [JAK2_p \|JAK2];
R29	JAK2_p \|JAK2	JAK2_p + JAK2_p	JAK2_p \|JAK2 → JAK2_p + JAK2_p	V(29) = K(29,1) * [JAK2_p \|JAK2];
R30	CDKN1B + MAPK1_p	MAPK1_p \|CDKN1B	CDKN1B + MAPK1_p → MAPK1_p \|CDKN1B	V(30) = K(30,1) * [MAPK1_p] * [CDKN1B] -K(30,2) * [MAPK1_p \|CDKN1B];
R31	MAPK1_p \|CDKN1B	CDKN1B_p + MAPK1_p	MAPK1_p \|CDKN1B → CDKN1B_p + MAPK1_p	V(31) = K(31,1) * [MAPK1_p \|CDKN1B];
R32	MAPK1_p + SMAD4	MAPK1_p \|SMAD4	MAPK1_p + SMAD4 → MAPK1_p \|SMAD4	V(32) = K(32,1) * [MAPK1_p] * [SMAD4] -K(32,2) * [MAPK1_p \|SMAD4];
R33	MAPK1_p \|SMAD4	MAPK1_p + SMAD4_p	MAPK1_p \|SMAD4 → MAPK1_p + SMAD4_p	V(33) = K(33,1) * [MAPK1_p \|SMAD4];
R34	IRS1 + RPS6KB1_p	RPS6KB1_p \|IRS1	IRS1 + RPS6KB1_p → RPS6KB1_p \|IRS1	V(34) = K(34,1) * [RPS6KB1_p] * [IRS1] -K(34,2) * [RPS6KB1_p \|IRS1];
R35	RPS6KB1_p \|IRS1	IRS1_p + RPS6KB1_p	RPS6KB1_p \|IRS1 → IRS1_p + RPS6KB1_p	V(35) = K(35,1) * [RPS6KB1_p \|IRS1];
R36	PDPK1_p + RPS6KB1	PDPK1_p \|RPS6KB1	PDPK1_p + RPS6KB1 → PDPK1_p \|RPS6KB1	V(36) = K(36,1) * [PDPK1_p] * [RPS6KB1] -K(36,2) * [PDPK1_p \|RPS6KB1];
R37	PDPK1_p \|RPS6KB1	PDPK1_p + RPS6KB1_p	PDPK1_p \|RPS6KB1 → PDPK1_p + RPS6KB1_p	V(37) = K(37,1) * [PDPK1_p \|RPS6KB1];
R38	JUN + MAPK1_p	MAPK1_p \|JUN	JUN + MAPK1_p → MAPK1_p \|JUN	V(38) = K(38,1) * [MAPK1_p] * [JUN] -K(38,2) * [MAPK1_p \|JUN];
R39	MAPK1_p \|JUN	JUN_p + MAPK1_p	MAPK1_p \|JUN → JUN_p + MAPK1_p	V(39) = K(39,1) * [MAPK1_p \|JUN];
R40	JAK2_p + MAP3K5	JAK2_p \|MAP3K5	JAK2_p + MAP3K5 → JAK2_p \|MAP3K5	V(40) = K(40,1) * [JAK2_p] * [MAP3K5] -K(40,2) * [JAK2_p \|MAP3K5];
R41	JAK2_p \|MAP3K5	JAK2_p + MAP3K5_p	JAK2_p \|MAP3K5 → JAK2_p + MAP3K5_p	V(41) = K(41,1) * [JAK2_p \|MAP3K5];
R42	FOS + MAPK1_p	MAPK1_p \|FOS	FOS + MAPK1_p → MAPK1_p \|FOS	V(42) = K(42,1) * [MAPK1_p] * [FOS] -K(42,2) * [MAPK1_p \|FOS];
R43	MAPK1_p \|FOS	FOS_p + MAPK1_p	MAPK1_p \|FOS → FOS_p + MAPK1_p	V(43) = K(43,1) * [MAPK1_p \|FOS];
R44	SRC + SRC_p	SRC_p \|SRC	SRC + SRC_p → SRC_p \|SRC	V(44) = K(44,1) * [SRC_p] * [SRC] -K(44,2) * [SRC_p \|SRC];
R45	SRC_p \|SRC	SRC_p + SRC_p	SRC_p \|SRC → SRC_p + SRC_p	V(45) = K(45,1) * [SRC_p \|SRC];
R46	SRC_p + TLR3	SRC_p \|TLR3	SRC_p + TLR3 → SRC_p \|TLR3	V(46) = K(46,1) * [SRC_p] * [TLR3] -K(46,2) * [SRC_p \|TLR3];
R47	SRC_p \|TLR3	SRC_p + TLR3_p	SRC_p \|TLR3 → SRC_p + TLR3_p	V(47) = K(47,1) * [SRC_p \|TLR3];
R48	MAPK1_p + SMAD2	MAPK1_p \|SMAD2	MAPK1_p + SMAD2 → MAPK1_p \|SMAD2	V(48) = K(48,1) * [MAPK1_p] * [SMAD2] -K(48,2) * [MAPK1_p \|SMAD2];
R49	MAPK1_p \|SMAD2	MAPK1_p + SMAD2_p	MAPK1_p \|SMAD2 → MAPK1_p + SMAD2_p	V(49) = K(49,1) * [MAPK1_p \|SMAD2];
R50	CTNNB1 + KIT_p	KIT_p \|CTNNB1	CTNNB1 + KIT_p → KIT_p \|CTNNB1	V(50) = K(50,1) * [KIT_p] * [CTNNB1] -K(50,2) * [KIT_p \|CTNNB1];
R51	KIT_p \|CTNNB1	CTNNB1_p + KIT_p	KIT_p \|CTNNB1 → CTNNB1_p + KIT_p	V(51) = K(51,1) * [KIT_p \|CTNNB1];
R52	MAPK1_p + RORA	MAPK1_p \|RORA	MAPK1_p + RORA → MAPK1_p \|RORA	V(52) = K(52,1) * [MAPK1_p] * [RORA] -K(52,2) * [MAPK1_p \|RORA];
R53	MAPK1_p \|RORA	MAPK1_p + RORA_p	MAPK1_p \|RORA → MAPK1_p + RORA_p	V(53) = K(53,1) * [MAPK1_p \|RORA];
R54	BCL2 + MAPK1_p	MAPK1_p \|BCL2	BCL2 + MAPK1_p → MAPK1_p \|BCL2	V(54) = K(54,1) * [MAPK1_p] * [BCL2] -K(54,2) * [MAPK1_p \|BCL2];
R55	MAPK1_p \|BCL2	BCL2_p + MAPK1_p	MAPK1_p \|BCL2 → BCL2_p + MAPK1_p	V(55) = K(55,1) * [MAPK1_p \|BCL2];
R56	INSR + INSR_p	INSR_p \|INSR	INSR + INSR_p → INSR_p \|INSR	V(56) = K(56,1) * [INSR_p] * [INSR] -K(56,2) * [INSR_p \|INSR];
R57	INSR_p \|INSR	INSR_p + INSR_p	INSR_p \|INSR → INSR_p + INSR_p	V(57) = K(57,1) * [INSR_p \|INSR];
R58	INSR_p + IRS1	INSR_p \|IRS1	INSR_p + IRS1 → INSR_p \|IRS1	V(58) = K(58,1) * [INSR_p] * [IRS1] -K(58,2) * [INSR_p \|IRS1];
R59	INSR_p \|IRS1	INSR_p + IRS1_p	INSR_p \|IRS1 → INSR_p + IRS1_p	V(59) = K(59,1) * [INSR_p \|IRS1];
R60	DUSP1 + MAPK1_p	MAPK1_p \|DUSP1	DUSP1 + MAPK1_p → MAPK1_p \|DUSP1	V(60) = K(60,1) * [MAPK1_p] * [DUSP1] -K(60,2) * [MAPK1_p \|DUSP1];
R61	MAPK1_p \|DUSP1	DUSP1_p + MAPK1_p	MAPK1_p \|DUSP1 → DUSP1_p + MAPK1_p	V(61) = K(61,1) * [MAPK1_p \|DUSP1];
R62	MAPK1_p + NR3C2	MAPK1_p \|NR3C2	MAPK1_p + NR3C2 → MAPK1_p \|NR3C2	V(62) = K(62,1) * [MAPK1_p] * [NR3C2] -K(62,2) * [MAPK1_p \|NR3C2];
R63	MAPK1_p \|NR3C2	MAPK1_p + NR3C2_p	MAPK1_p \|NR3C2 → MAPK1_p + NR3C2_p	V(63) = K(63,1) * [MAPK1_p \|NR3C2];
R64	PKN1 + PKN1_p	PKN1_p \|PKN1	PKN1 + PKN1_p → PKN1_p \|PKN1	V(64) = K(64,1) * [PKN1_p] * [PKN1] -K(64,2) * [PKN1_p \|PKN1];
R65	PKN1_p \|PKN1	PKN1_p + PKN1_p	PKN1_p \|PKN1 → PKN1_p + PKN1_p	V(65) = K(65,1) * [PKN1_p \|PKN1];
R66	HSPB1 + RPS6KB1_p	RPS6KB1_p \|HSPB1	HSPB1 + RPS6KB1_p → RPS6KB1_p \|HSPB1	V(66) = K(66,1) * [RPS6KB1_p] * [HSPB1] -K(66,2) * [RPS6KB1_p \|HSPB1];
R67	RPS6KB1_p \|HSPB1	HSPB1_p + RPS6KB1_p	RPS6KB1_p \|HSPB1 → HSPB1_p + RPS6KB1_p	V(67) = K(67,1) * [RPS6KB1_p \|HSPB1];
R68	MAPK7 + MAPK7_p	MAPK7_p \|MAPK7	MAPK7 + MAPK7_p → MAPK7_p \|MAPK7	V(68) = K(68,1) * [MAPK7_p] * [MAPK7] -K(68,2) * [MAPK7_p \|MAPK7];
R69	MAPK7_p \|MAPK7	MAPK7_p + MAPK7_p	MAPK7_p \|MAPK7 → MAPK7_p + MAPK7_p	V(69) = K(69,1) * [MAPK7_p \|MAPK7];
R70	KIT + KIT_p	KIT_p \|KIT	KIT + KIT_p → KIT_p \|KIT	V(70) = K(70,1) * [KIT_p] * [KIT] -K(70,2) * [KIT_p \|KIT];
R71	KIT_p \|KIT	KIT_p + KIT_p	KIT_p \|KIT → KIT_p + KIT_p	V(71) = K(71,1) * [KIT_p \|KIT];
R72	FOXO1 + MAPK1_p	MAPK1_p \|FOXO1	FOXO1 + MAPK1_p → MAPK1_p \|FOXO1	V(72) = K(72,1) * [MAPK1_p] * [FOXO1] -K(72,2) * [MAPK1_p \|FOXO1];
R73	MAPK1_p \|FOXO1	FOXO1_p + MAPK1_p	MAPK1_p \|FOXO1 → FOXO1_p + MAPK1_p	V(73) = K(73,1) * [MAPK1_p \|FOXO1];
R74	ATR + PARP1	ATR \|PARP1	ATR + PARP1 → ATR \|PARP1	V(74) = K(74,1) * [ATR] * [PARP1] -K(74,2) * [ATR \|PARP1];
R75	ATR \|PARP1	ATR + PARP1_p	ATR \|PARP1 → ATR + PARP1_p	V(75) = K(75,1) * [ATR \|PARP1];
R76	JAK2_p + STAT1	JAK2_p \|STAT1	JAK2_p + STAT1 → JAK2_p \|STAT1	V(76) = K(76,1) * [JAK2_p] * [STAT1] -K(76,2) * [JAK2_p \|STAT1];
R77	JAK2_p \|STAT1	JAK2_p + STAT1_p	JAK2_p \|STAT1 → JAK2_p + STAT1_p	V(77) = K(77,1) * [JAK2_p \|STAT1];
R78	EGFR + SRC_p	SRC_p \|EGFR	EGFR + SRC_p → SRC_p \|EGFR	V(78) = K(78,1) * [SRC_p] * [EGFR] -K(78,2) * [SRC_p \|EGFR];
R79	SRC_p \|EGFR	EGFR_p + SRC_p	SRC_p \|EGFR → EGFR_p + SRC_p	V(79) = K(79,1) * [SRC_p \|EGFR];
R80	SRC_p + STAT1	SRC_p \|STAT1	SRC_p + STAT1 → SRC_p \|STAT1	V(80) = K(80,1) * [SRC_p] * [STAT1] -K(80,2) * [SRC_p \|STAT1];
R81	SRC_p \|STAT1	SRC_p + STAT1_p	SRC_p \|STAT1 → SRC_p + STAT1_p	V(81) = K(81,1) * [SRC_p \|STAT1];
R82	PDPK1_p + SGK1	PDPK1_p \|SGK1	PDPK1_p + SGK1 → PDPK1_p \|SGK1	V(82) = K(82,1) * [PDPK1_p] * [SGK1] -K(82,2) * [PDPK1_p \|SGK1];
R83	PDPK1_p \|SGK1	PDPK1_p + SGK1_p	PDPK1_p \|SGK1 → PDPK1_p + SGK1_p	V(83) = K(83,1) * [PDPK1_p \|SGK1];
R84	ERN1 + ERN1_p	ERN1_p \|ERN1	ERN1 + ERN1_p → ERN1_p \|ERN1	V(84) = K(84,1) * [ERN1_p] * [ERN1] -K(84,2) * [ERN1_p \|ERN1];
R85	ERN1_p \|ERN1	ERN1_p + ERN1_p	ERN1_p \|ERN1 → ERN1_p + ERN1_p	V(85) = K(85,1) * [ERN1_p \|ERN1];
R86	SRC_p + TRAF6	SRC_p \|TRAF6	SRC_p + TRAF6 → SRC_p \|TRAF6	V(86) = K(86,1) * [SRC_p] * [TRAF6] -K(86,2) * [SRC_p \|TRAF6];
R87	SRC_p \|TRAF6	SRC_p + TRAF6_p	SRC_p \|TRAF6 → SRC_p + TRAF6_p	V(87) = K(87,1) * [SRC_p \|TRAF6];
R88	MAP3K5 + RPS6KA3_p	RPS6KA3_p \|MAP3K5	MAP3K5 + RPS6KA3_p → RPS6KA3_p \|MAP3K5	V(88) = K(88,1) * [RPS6KA3_p] * [MAP3K5] -K(88,2) * [RPS6KA3_p \|MAP3K5];
R89	RPS6KA3_p \|MAP3K5	MAP3K5_p + RPS6KA3_p	RPS6KA3_p \|MAP3K5 → MAP3K5_p + RPS6KA3_p	V(89) = K(89,1) * [RPS6KA3_p \|MAP3K5];
R90	IGF1R + SRC_p	SRC_p \|IGF1R	IGF1R + SRC_p → SRC_p \|IGF1R	V(90) = K(90,1) * [SRC_p] * [IGF1R] -K(90,2) * [SRC_p \|IGF1R];
R91	SRC_p \|IGF1R	IGF1R_p + SRC_p	SRC_p \|IGF1R → IGF1R_p + SRC_p	V(91) = K(91,1) * [SRC_p \|IGF1R];
R92	MAPK1_p + SIGNOR-C154	MAPK1_p \|SIGNOR-C154	MAPK1_p + SIGNOR-C154 → MAPK1_p \|SIGNOR-C154	V(92) = K(92,1) * [MAPK1_p] * [SIGNOR-C154] -K(92,2) * [MAPK1_p \|SIGNOR-C154];
R93	MAPK1_p \|SIGNOR-C154	MAPK1_p + SIGNOR-C154_p	MAPK1_p \|SIGNOR-C154 → MAPK1_p + SIGNOR-C154_p	V(93) = K(93,1) * [MAPK1_p \|SIGNOR-C154];
R94	PINK1 + UBC	PINK1 \|UBC	PINK1 + UBC → PINK1 \|UBC	V(94) = K(94,1) * [PINK1] * [UBC] -K(94,2) * [PINK1 \|UBC];
R95	PINK1 \|UBC	PINK1 + UBC_p	PINK1 \|UBC → PINK1 + UBC_p	V(95) = K(95,1) * [PINK1 \|UBC];
R96	IGF1R + IGF1R_p	IGF1R_p \|IGF1R	IGF1R + IGF1R_p → IGF1R_p \|IGF1R	V(96) = K(96,1) * [IGF1R_p] * [IGF1R] -K(96,2) * [IGF1R_p \|IGF1R];
R97	IGF1R_p \|IGF1R	IGF1R_p + IGF1R_p	IGF1R_p \|IGF1R → IGF1R_p + IGF1R_p	V(97) = K(97,1) * [IGF1R_p \|IGF1R];
R98	FOXO1 + SGK1_p	SGK1_p \|FOXO1	FOXO1 + SGK1_p → SGK1_p \|FOXO1	V(98) = K(98,1) * [SGK1_p] * [FOXO1] -K(98,2) * [SGK1_p \|FOXO1];
R99	SGK1_p \|FOXO1	FOXO1_p + SGK1_p	SGK1_p \|FOXO1 → FOXO1_p + SGK1_p	V(99) = K(99,1) * [SGK1_p \|FOXO1];
R100	HIPK2 + HIPK2_p	HIPK2_p \|HIPK2	HIPK2 + HIPK2_p → HIPK2_p \|HIPK2	V(100) = K(100,1) * [HIPK2_p] * [HIPK2] -K(100,2) * [HIPK2_p \|HIPK2];
R101	HIPK2_p \|HIPK2	HIPK2_p + HIPK2_p	HIPK2_p \|HIPK2 → HIPK2_p + HIPK2_p	V(101) = K(101,1) * [HIPK2_p \|HIPK2];
R102	PDPK1 + PDPK1_p	PDPK1_p \|PDPK1	PDPK1 + PDPK1_p → PDPK1_p \|PDPK1	V(102) = K(102,1) * [PDPK1_p] * [PDPK1] -K(102,2) * [PDPK1_p \|PDPK1];
R103	PDPK1_p \|PDPK1	PDPK1_p + PDPK1_p	PDPK1_p \|PDPK1 → PDPK1_p + PDPK1_p	V(103) = K(103,1) * [PDPK1_p \|PDPK1];
R104	CDKN1B + SGK1_p	SGK1_p \|CDKN1B	CDKN1B + SGK1_p → SGK1_p \|CDKN1B	V(104) = K(104,1) * [SGK1_p] * [CDKN1B] -K(104,2) * [SGK1_p \|CDKN1B];
R105	SGK1_p \|CDKN1B	CDKN1B_p + SGK1_p	SGK1_p \|CDKN1B → CDKN1B_p + SGK1_p	V(105) = K(105,1) * [SGK1_p \|CDKN1B];
R106	CREB1 + RPS6KA3_p	RPS6KA3_p \|CREB1	CREB1 + RPS6KA3_p → RPS6KA3_p \|CREB1	V(106) = K(106,1) * [RPS6KA3_p] * [CREB1] -K(106,2) * [RPS6KA3_p \|CREB1];
R107	RPS6KA3_p \|CREB1	CREB1_p + RPS6KA3_p	RPS6KA3_p \|CREB1 → CREB1_p + RPS6KA3_p	V(107) = K(107,1) * [RPS6KA3_p \|CREB1];
R108	PDPK1 + SRC_p	SRC_p \|PDPK1	PDPK1 + SRC_p → SRC_p \|PDPK1	V(108) = K(108,1) * [SRC_p] * [PDPK1] -K(108,2) * [SRC_p \|PDPK1];
R109	SRC_p \|PDPK1	PDPK1_p + SRC_p	SRC_p \|PDPK1 → PDPK1_p + SRC_p	V(109) = K(109,1) * [SRC_p \|PDPK1];
R110	EGFR + MAPK1_p	MAPK1_p \|EGFR	EGFR + MAPK1_p → MAPK1_p \|EGFR	V(110) = K(110,1) * [MAPK1_p] * [EGFR] -K(110,2) * [MAPK1_p \|EGFR];
R111	MAPK1_p \|EGFR	EGFR_p + MAPK1_p	MAPK1_p \|EGFR → EGFR_p + MAPK1_p	V(111) = K(111,1) * [MAPK1_p \|EGFR];
R112	PTEN + SRC_p	SRC_p \|PTEN	PTEN + SRC_p → SRC_p \|PTEN	V(112) = K(112,1) * [SRC_p] * [PTEN] -K(112,2) * [SRC_p \|PTEN];
R113	SRC_p \|PTEN	PTEN_p + SRC_p	SRC_p \|PTEN → PTEN_p + SRC_p	V(113) = K(113,1) * [SRC_p \|PTEN];
R114	MAP3K5 + MAP3K5_p	MAP3K5_p \|MAP3K5	MAP3K5 + MAP3K5_p → MAP3K5_p \|MAP3K5	V(114) = K(114,1) * [MAP3K5_p] * [MAP3K5] -K(114,2) * [MAP3K5_p \|MAP3K5];
R115	MAP3K5_p \|MAP3K5	MAP3K5_p + MAP3K5_p	MAP3K5_p \|MAP3K5 → MAP3K5_p + MAP3K5_p	V(115) = K(115,1) * [MAP3K5_p \|MAP3K5];
R116	DNMT1 + PRKAA1	PRKAA1 \|DNMT1	DNMT1 + PRKAA1 → PRKAA1 \|DNMT1	V(116) = K(116,1) * [PRKAA1] * [DNMT1] -K(116,2) * [PRKAA1 \|DNMT1];
R117	PRKAA1 \|DNMT1	DNMT1_p + PRKAA1	PRKAA1 \|DNMT1 → DNMT1_p + PRKAA1	V(117) = K(117,1) * [PRKAA1 \|DNMT1];
R118	MAPK1_p + SP1	MAPK1_p \|SP1	MAPK1_p + SP1 → MAPK1_p \|SP1	V(118) = K(118,1) * [MAPK1_p] * [SP1] -K(118,2) * [MAPK1_p \|SP1];
R119	MAPK1_p \|SP1	MAPK1_p + SP1_p	MAPK1_p \|SP1 → MAPK1_p + SP1_p	V(119) = K(119,1) * [MAPK1_p \|SP1];
R120	PTEN + ROCK1	ROCK1 \|PTEN	PTEN + ROCK1 → ROCK1 \|PTEN	V(120) = K(120,1) * [ROCK1] * [PTEN] -K(120,2) * [ROCK1 \|PTEN];
R121	ROCK1 \|PTEN	PTEN_p + ROCK1	ROCK1 \|PTEN → PTEN_p + ROCK1	V(121) = K(121,1) * [ROCK1 \|PTEN];
R122	MAPK1_p + STAT5A	MAPK1_p \|STAT5A	MAPK1_p + STAT5A → MAPK1_p \|STAT5A	V(122) = K(122,1) * [MAPK1_p] * [STAT5A] -K(122,2) * [MAPK1_p \|STAT5A];
R123	MAPK1_p \|STAT5A	MAPK1_p + STAT5A_p	MAPK1_p \|STAT5A → MAPK1_p + STAT5A_p	V(123) = K(123,1) * [MAPK1_p \|STAT5A];
R124	ANXA1 + SRC_p	SRC_p \|ANXA1	ANXA1 + SRC_p → SRC_p \|ANXA1	V(124) = K(124,1) * [SRC_p] * [ANXA1] -K(124,2) * [SRC_p \|ANXA1];
R125	SRC_p \|ANXA1	ANXA1_p + SRC_p	SRC_p \|ANXA1 → ANXA1_p + SRC_p	V(125) = K(125,1) * [SRC_p \|ANXA1];
R126	PDPK1_p + RPS6KA3	PDPK1_p \|RPS6KA3	PDPK1_p + RPS6KA3 → PDPK1_p \|RPS6KA3	V(126) = K(126,1) * [PDPK1_p] * [RPS6KA3] -K(126,2) * [PDPK1_p \|RPS6KA3];
R127	PDPK1_p \|RPS6KA3	PDPK1_p + RPS6KA3_p	PDPK1_p \|RPS6KA3 → PDPK1_p + RPS6KA3_p	V(127) = K(127,1) * [PDPK1_p \|RPS6KA3];
R128	PTPRJ + SRC_p	SRC_p \|PTPRJ	PTPRJ + SRC_p → SRC_p \|PTPRJ	V(128) = K(128,1) * [SRC_p] * [PTPRJ] -K(128,2) * [SRC_p \|PTPRJ];
R129	SRC_p \|PTPRJ	PTPRJ_p + SRC_p	SRC_p \|PTPRJ → PTPRJ_p + SRC_p	V(129) = K(129,1) * [SRC_p \|PTPRJ];
R130	CDKN1A + MAPK1_p	MAPK1_p \|CDKN1A	CDKN1A + MAPK1_p → MAPK1_p \|CDKN1A	V(130) = K(130,1) * [MAPK1_p] * [CDKN1A] -K(130,2) * [MAPK1_p \|CDKN1A];
R131	MAPK1_p \|CDKN1A	CDKN1A_p + MAPK1_p	MAPK1_p \|CDKN1A → CDKN1A_p + MAPK1_p	V(131) = K(131,1) * [MAPK1_p \|CDKN1A];
R132	FOXO1 + PRKAA1	PRKAA1 \|FOXO1	FOXO1 + PRKAA1 → PRKAA1 \|FOXO1	V(132) = K(132,1) * [PRKAA1] * [FOXO1] -K(132,2) * [PRKAA1 \|FOXO1];
R133	PRKAA1 \|FOXO1	FOXO1_p + PRKAA1	PRKAA1 \|FOXO1 → FOXO1_p + PRKAA1	V(133) = K(133,1) * [PRKAA1 \|FOXO1];
R134	JAK2 + MAPK1_p	MAPK1_p \|JAK2	JAK2 + MAPK1_p → MAPK1_p \|JAK2	V(134) = K(134,1) * [MAPK1_p] * [JAK2] -K(134,2) * [MAPK1_p \|JAK2];
R135	MAPK1_p \|JAK2	JAK2_p + MAPK1_p	MAPK1_p \|JAK2 → JAK2_p + MAPK1_p	V(135) = K(135,1) * [MAPK1_p \|JAK2];
R136	MAPK1_p + STIM1	MAPK1_p \|STIM1	MAPK1_p + STIM1 → MAPK1_p \|STIM1	V(136) = K(136,1) * [MAPK1_p] * [STIM1] -K(136,2) * [MAPK1_p \|STIM1];
R137	MAPK1_p \|STIM1	MAPK1_p + STIM1_p	MAPK1_p \|STIM1 → MAPK1_p + STIM1_p	V(137) = K(137,1) * [MAPK1_p \|STIM1];
R138	IGF1R_p + PCNA	IGF1R_p \|PCNA	IGF1R_p + PCNA → IGF1R_p \|PCNA	V(138) = K(138,1) * [IGF1R_p] * [PCNA] -K(138,2) * [IGF1R_p \|PCNA];
R139	IGF1R_p \|PCNA	IGF1R_p + PCNA_p	IGF1R_p \|PCNA → IGF1R_p + PCNA_p	V(139) = K(139,1) * [IGF1R_p \|PCNA];
R140	IGF1R_p + PDPK1	IGF1R_p \|PDPK1	IGF1R_p + PDPK1 → IGF1R_p \|PDPK1	V(140) = K(140,1) * [IGF1R_p] * [PDPK1] -K(140,2) * [IGF1R_p \|PDPK1];
R141	IGF1R_p \|PDPK1	IGF1R_p + PDPK1_p	IGF1R_p \|PDPK1 → IGF1R_p + PDPK1_p	V(141) = K(141,1) * [IGF1R_p \|PDPK1];
R142	MAPK1_p + PARP1	MAPK1_p \|PARP1	MAPK1_p + PARP1 → MAPK1_p \|PARP1	V(142) = K(142,1) * [MAPK1_p] * [PARP1] -K(142,2) * [MAPK1_p \|PARP1];
R143	MAPK1_p \|PARP1	MAPK1_p + PARP1_p	MAPK1_p \|PARP1 → MAPK1_p + PARP1_p	V(143) = K(143,1) * [MAPK1_p \|PARP1];
R144	CLTC + SRC_p	SRC_p \|CLTC	CLTC + SRC_p → SRC_p \|CLTC	V(144) = K(144,1) * [SRC_p] * [CLTC] -K(144,2) * [SRC_p \|CLTC];
R145	SRC_p \|CLTC	CLTC_p + SRC_p	SRC_p \|CLTC → CLTC_p + SRC_p	V(145) = K(145,1) * [SRC_p \|CLTC];
R146	JAK2_p + STAT6	JAK2_p \|STAT6	JAK2_p + STAT6 → JAK2_p \|STAT6	V(146) = K(146,1) * [JAK2_p] * [STAT6] -K(146,2) * [JAK2_p \|STAT6];
R147	JAK2_p \|STAT6	JAK2_p + STAT6_p	JAK2_p \|STAT6 → JAK2_p + STAT6_p	V(147) = K(147,1) * [JAK2_p \|STAT6];
R148	MAP3K14_p + NFKB2	MAP3K14_p \|NFKB2	MAP3K14_p + NFKB2 → MAP3K14_p \|NFKB2	V(148) = K(148,1) * [MAP3K14_p] * [NFKB2] -K(148,2) * [MAP3K14_p \|NFKB2];
R149	MAP3K14_p \|NFKB2	MAP3K14_p + NFKB2_p	MAP3K14_p \|NFKB2 → MAP3K14_p + NFKB2_p	V(149) = K(149,1) * [MAP3K14_p \|NFKB2];
R150	FOXO1 + PKN1_p	PKN1_p \|FOXO1	FOXO1 + PKN1_p → PKN1_p \|FOXO1	V(150) = K(150,1) * [PKN1_p] * [FOXO1] -K(150,2) * [PKN1_p \|FOXO1];
R151	PKN1_p \|FOXO1	FOXO1_p + PKN1_p	PKN1_p \|FOXO1 → FOXO1_p + PKN1_p	V(151) = K(151,1) * [PKN1_p \|FOXO1];
R152	CASP9 + MAPK1_p	MAPK1_p \|CASP9	CASP9 + MAPK1_p → MAPK1_p \|CASP9	V(152) = K(152,1) * [MAPK1_p] * [CASP9] -K(152,2) * [MAPK1_p \|CASP9];
R153	MAPK1_p \|CASP9	CASP9_p + MAPK1_p	MAPK1_p \|CASP9 → CASP9_p + MAPK1_p	V(153) = K(153,1) * [MAPK1_p \|CASP9];
R154	RICTOR + RPS6KB1_p	RPS6KB1_p \|RICTOR	RICTOR + RPS6KB1_p → RPS6KB1_p \|RICTOR	V(154) = K(154,1) * [RPS6KB1_p] * [RICTOR] -K(154,2) * [RPS6KB1_p \|RICTOR];
R155	RPS6KB1_p \|RICTOR	RICTOR_p + RPS6KB1_p	RPS6KB1_p \|RICTOR → RICTOR_p + RPS6KB1_p	V(155) = K(155,1) * [RPS6KB1_p \|RICTOR];
R156	MAP3K14 + MAP3K14_p	MAP3K14_p \|MAP3K14	MAP3K14 + MAP3K14_p → MAP3K14_p \|MAP3K14	V(156) = K(156,1) * [MAP3K14_p] * [MAP3K14] -K(156,2) * [MAP3K14_p \|MAP3K14];
R157	MAP3K14_p \|MAP3K14	MAP3K14_p + MAP3K14_p	MAP3K14_p \|MAP3K14 → MAP3K14_p + MAP3K14_p	V(157) = K(157,1) * [MAP3K14_p \|MAP3K14];
R158	IGF1R_p + IRS2	IGF1R_p \|IRS2	IGF1R_p + IRS2 → IGF1R_p \|IRS2	V(158) = K(158,1) * [IGF1R_p] * [IRS2] -K(158,2) * [IGF1R_p \|IRS2];
R159	IGF1R_p \|IRS2	IGF1R_p + IRS2_p	IGF1R_p \|IRS2 → IGF1R_p + IRS2_p	V(159) = K(159,1) * [IGF1R_p \|IRS2];
R160	CDKN1B + JAK2_p	JAK2_p \|CDKN1B	CDKN1B + JAK2_p → JAK2_p \|CDKN1B	V(160) = K(160,1) * [JAK2_p] * [CDKN1B] -K(160,2) * [JAK2_p \|CDKN1B];
R161	JAK2_p \|CDKN1B	CDKN1B_p + JAK2_p	JAK2_p \|CDKN1B → CDKN1B_p + JAK2_p	V(161) = K(161,1) * [JAK2_p \|CDKN1B];
R162	SMAD1 + SMAD4	SMAD1 \|SMAD4	SMAD1 + SMAD4 → SMAD1 \|SMAD4	V(162) = K(162,1) * [SMAD1] * [SMAD4] -K(162,2) * [SMAD1 \|SMAD4];
R163	SMAD1 \|SMAD4	SMAD1 + SMAD4_p	SMAD1 \|SMAD4 → SMAD1 + SMAD4_p	V(163) = K(163,1) * [SMAD1 \|SMAD4];
R164	FOS + RPS6KA3_p	RPS6KA3_p \|FOS	FOS + RPS6KA3_p → RPS6KA3_p \|FOS	V(164) = K(164,1) * [RPS6KA3_p] * [FOS] -K(164,2) * [RPS6KA3_p \|FOS];
R165	RPS6KA3_p \|FOS	FOS_p + RPS6KA3_p	RPS6KA3_p \|FOS → FOS_p + RPS6KA3_p	V(165) = K(165,1) * [RPS6KA3_p \|FOS];
R166	KIT_p + STAT1	KIT_p \|STAT1	KIT_p + STAT1 → KIT_p \|STAT1	V(166) = K(166,1) * [KIT_p] * [STAT1] -K(166,2) * [KIT_p \|STAT1];
R167	KIT_p \|STAT1	KIT_p + STAT1_p	KIT_p \|STAT1 → KIT_p + STAT1_p	V(167) = K(167,1) * [KIT_p \|STAT1];
R168	RPS6KA3 + RPS6KA3_p	RPS6KA3_p \|RPS6KA3	RPS6KA3 + RPS6KA3_p → RPS6KA3_p \|RPS6KA3	V(168) = K(168,1) * [RPS6KA3_p] * [RPS6KA3] -K(168,2) * [RPS6KA3_p \|RPS6KA3];
R169	RPS6KA3_p \|RPS6KA3	RPS6KA3_p + RPS6KA3_p	RPS6KA3_p \|RPS6KA3 → RPS6KA3_p + RPS6KA3_p	V(169) = K(169,1) * [RPS6KA3_p \|RPS6KA3];
R170	HDAC4 + PRKAA1	PRKAA1 \|HDAC4	HDAC4 + PRKAA1 → PRKAA1 \|HDAC4	V(170) = K(170,1) * [PRKAA1] * [HDAC4] -K(170,2) * [PRKAA1 \|HDAC4];
R171	PRKAA1 \|HDAC4	HDAC4_p + PRKAA1	PRKAA1 \|HDAC4 → HDAC4_p + PRKAA1	V(171) = K(171,1) * [PRKAA1 \|HDAC4];
R172	IRS1 + MAPK1_p	MAPK1_p \|IRS1	IRS1 + MAPK1_p → MAPK1_p \|IRS1	V(172) = K(172,1) * [MAPK1_p] * [IRS1] -K(172,2) * [MAPK1_p \|IRS1];
R173	MAPK1_p \|IRS1	IRS1_p + MAPK1_p	MAPK1_p \|IRS1 → IRS1_p + MAPK1_p	V(173) = K(173,1) * [MAPK1_p \|IRS1];
R174	NR4A1 + RPS6KA3_p	RPS6KA3_p \|NR4A1	NR4A1 + RPS6KA3_p → RPS6KA3_p \|NR4A1	V(174) = K(174,1) * [RPS6KA3_p] * [NR4A1] -K(174,2) * [RPS6KA3_p \|NR4A1];
R175	RPS6KA3_p \|NR4A1	NR4A1_p + RPS6KA3_p	RPS6KA3_p \|NR4A1 → NR4A1_p + RPS6KA3_p	V(175) = K(175,1) * [RPS6KA3_p \|NR4A1];
R176	ROCK1 + TP53	ROCK1 \|TP53	ROCK1 + TP53 → ROCK1 \|TP53	V(176) = K(176,1) * [ROCK1] * [TP53] -K(176,2) * [ROCK1 \|TP53];
R177	ROCK1 \|TP53	ROCK1 + TP53_p	ROCK1 \|TP53 → ROCK1 + TP53_p	V(177) = K(177,1) * [ROCK1 \|TP53];
R178	RAC1 + SRC_p	SRC_p \|RAC1	RAC1 + SRC_p → SRC_p \|RAC1	V(178) = K(178,1) * [SRC_p] * [RAC1] -K(178,2) * [SRC_p \|RAC1];
R179	SRC_p \|RAC1	RAC1_p + SRC_p	SRC_p \|RAC1 → RAC1_p + SRC_p	V(179) = K(179,1) * [SRC_p \|RAC1];
R180	MAPK1 + MAPK1_p	MAPK1_p \|MAPK1	MAPK1 + MAPK1_p → MAPK1_p \|MAPK1	V(180) = K(180,1) * [MAPK1_p] * [MAPK1] -K(180,2) * [MAPK1_p \|MAPK1];
R181	MAPK1_p \|MAPK1	MAPK1_p + MAPK1_p	MAPK1_p \|MAPK1 → MAPK1_p + MAPK1_p	V(181) = K(181,1) * [MAPK1_p \|MAPK1];
R182	MAPK1_p + RRAS	MAPK1_p \|RRAS	MAPK1_p + RRAS → MAPK1_p \|RRAS	V(182) = K(182,1) * [MAPK1_p] * [RRAS] -K(182,2) * [MAPK1_p \|RRAS];
R183	MAPK1_p \|RRAS	MAPK1_p + RRAS_p	MAPK1_p \|RRAS → MAPK1_p + RRAS_p	V(183) = K(183,1) * [MAPK1_p \|RRAS];
R184	CDH1 + SRC_p	SRC_p \|CDH1	CDH1 + SRC_p → SRC_p \|CDH1	V(184) = K(184,1) * [SRC_p] * [CDH1] -K(184,2) * [SRC_p \|CDH1];
R185	SRC_p \|CDH1	CDH1_p + SRC_p	SRC_p \|CDH1 → CDH1_p + SRC_p	V(185) = K(185,1) * [SRC_p \|CDH1];
R186	MAPK1_p + ZFP36	MAPK1_p \|ZFP36	MAPK1_p + ZFP36 → MAPK1_p \|ZFP36	V(186) = K(186,1) * [MAPK1_p] * [ZFP36] -K(186,2) * [MAPK1_p \|ZFP36];
R187	MAPK1_p \|ZFP36	MAPK1_p + ZFP36_p	MAPK1_p \|ZFP36 → MAPK1_p + ZFP36_p	V(187) = K(187,1) * [MAPK1_p \|ZFP36];
R188	MAPK1_p + RCAN1	MAPK1_p \|RCAN1	MAPK1_p + RCAN1 → MAPK1_p \|RCAN1	V(188) = K(188,1) * [MAPK1_p] * [RCAN1] -K(188,2) * [MAPK1_p \|RCAN1];
R189	MAPK1_p \|RCAN1	MAPK1_p + RCAN1_p	MAPK1_p \|RCAN1 → MAPK1_p + RCAN1_p	V(189) = K(189,1) * [MAPK1_p \|RCAN1];
R190	EGFR + JAK2_p	JAK2_p \|EGFR	EGFR + JAK2_p → JAK2_p \|EGFR	V(190) = K(190,1) * [JAK2_p] * [EGFR] -K(190,2) * [JAK2_p \|EGFR];
R191	JAK2_p \|EGFR	EGFR_p + JAK2_p	JAK2_p \|EGFR → EGFR_p + JAK2_p	V(191) = K(191,1) * [JAK2_p \|EGFR];
R192	EGFR + PKN1_p	PKN1_p \|EGFR	EGFR + PKN1_p → PKN1_p \|EGFR	V(192) = K(192,1) * [PKN1_p] * [EGFR] -K(192,2) * [PKN1_p \|EGFR];
R193	PKN1_p \|EGFR	EGFR_p + PKN1_p	PKN1_p \|EGFR → EGFR_p + PKN1_p	V(193) = K(193,1) * [PKN1_p \|EGFR];
R194	KIT + SRC_p	SRC_p \|KIT	KIT + SRC_p → SRC_p \|KIT	V(194) = K(194,1) * [SRC_p] * [KIT] -K(194,2) * [SRC_p \|KIT];
R195	SRC_p \|KIT	KIT_p + SRC_p	SRC_p \|KIT → KIT_p + SRC_p	V(195) = K(195,1) * [SRC_p \|KIT];
R196	SGK1_p + SP1	SGK1_p \|SP1	SGK1_p + SP1 → SGK1_p \|SP1	V(196) = K(196,1) * [SGK1_p] * [SP1] -K(196,2) * [SGK1_p \|SP1];
R197	SGK1_p \|SP1	SGK1_p + SP1_p	SGK1_p \|SP1 → SGK1_p + SP1_p	V(197) = K(197,1) * [SGK1_p \|SP1];
R198	HIPK2 + PRKAA1	PRKAA1 \|HIPK2	HIPK2 + PRKAA1 → PRKAA1 \|HIPK2	V(198) = K(198,1) * [PRKAA1] * [HIPK2] -K(198,2) * [PRKAA1 \|HIPK2];
R199	PRKAA1 \|HIPK2	HIPK2_p + PRKAA1	PRKAA1 \|HIPK2 → HIPK2_p + PRKAA1	V(199) = K(199,1) * [PRKAA1 \|HIPK2];