Endothelial Cell_Parametric ODE Equations

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Reaction ID	Reactants	Products	Original Text	ODE Equations
R1	SMAD2_p + SMAD4_p	SIGNOR-C8	SMAD2_p + SMAD4_p → SIGNOR-C8	V(1) = K(1,1) * [SMAD2_p] * [SMAD4_p] -K(1,2) * [SIGNOR-C8];
R2	SMAD3_p + SMAD4_p	SIGNOR-C9	SMAD3_p + SMAD4_p → SIGNOR-C9	V(2) = K(2,1) * [SMAD4_p] * [SMAD3_p] -K(2,2) * [SIGNOR-C9];
R3	JUN_p + SMAD4_p	SIGNOR-C10	JUN_p + SMAD4_p → SIGNOR-C10	V(3) = K(3,1) * [SMAD4_p] * [JUN_p] -K(3,2) * [SIGNOR-C10];
R4	SP1_p + STAT3_p	SIGNOR-C74	SP1_p + STAT3_p → SIGNOR-C74	V(4) = K(4,1) * [STAT3_p] * [SP1_p] -K(4,2) * [SIGNOR-C74];
R5	NR3C1 + STAT5A_p	SIGNOR-C84	NR3C1 + STAT5A_p → SIGNOR-C84	V(5) = K(5,1) * [NR3C1] * [STAT5A_p] -K(5,2) * [SIGNOR-C84];
R6	SMAD1 + SMAD1 + SMAD4_p	SIGNOR-C85	SMAD1 + SMAD1 + SMAD4_p → SIGNOR-C85	V(6) = K(6,1) * [SMAD4_p] * [SMAD1] * [SMAD1] -K(6,2) * [SIGNOR-C85];
R7	JUN_p + SMAD3_p	SIGNOR-C86	JUN_p + SMAD3_p → SIGNOR-C86	V(7) = K(7,1) * [JUN_p] * [SMAD3_p] -K(7,2) * [SIGNOR-C86];
R8	STAT1_p + STAT3_p	SIGNOR-C118	STAT1_p + STAT3_p → SIGNOR-C118	V(8) = K(8,1) * [STAT1_p] * [STAT3_p] -K(8,2) * [SIGNOR-C118];
R9	FOS_p + FOS_p + FOS_p + FOS_p + JUN_p + JUN_p + JUN_p + JUN_p	SIGNOR-C154	FOS_p + FOS_p + FOS_p + FOS_p + JUN_p + JUN_p + JUN_p + JUN_p → SIGNOR-C154	V(9) = K(9,1) * [FOS_p] * [JUN_p] * [JUN_p] * [FOS_p] * [JUN_p] * [FOS_p] * [FOS_p] * [JUN_p] -K(9,2) * [SIGNOR-C154];
R10	SMAD2 + TGFBR1	TGFBR1 \|SMAD2	SMAD2 + TGFBR1 → TGFBR1 \|SMAD2	V(10) = K(10,1) * [TGFBR1] * [SMAD2] -K(10,2) * [TGFBR1 \|SMAD2];
R11	TGFBR1 \|SMAD2	SMAD2_p + TGFBR1	TGFBR1 \|SMAD2 → SMAD2_p + TGFBR1	V(11) = K(11,1) * [TGFBR1 \|SMAD2];
R12	EP300 + MAPK1_p	MAPK1_p \|EP300	EP300 + MAPK1_p → MAPK1_p \|EP300	V(12) = K(12,1) * [MAPK1_p] * [EP300] -K(12,2) * [MAPK1_p \|EP300];
R13	MAPK1_p \|EP300	EP300_p + MAPK1_p	MAPK1_p \|EP300 → EP300_p + MAPK1_p	V(13) = K(13,1) * [MAPK1_p \|EP300];
R14	MAPK1_p + NR3C1	MAPK1_p \|NR3C1	MAPK1_p + NR3C1 → MAPK1_p \|NR3C1	V(14) = K(14,1) * [MAPK1_p] * [NR3C1] -K(14,2) * [MAPK1_p \|NR3C1];
R15	MAPK1_p \|NR3C1	MAPK1_p + NR3C1_p	MAPK1_p \|NR3C1 → MAPK1_p + NR3C1_p	V(15) = K(15,1) * [MAPK1_p \|NR3C1];
R16	MAPK1_p + RPS6KA3	MAPK1_p \|RPS6KA3	MAPK1_p + RPS6KA3 → MAPK1_p \|RPS6KA3	V(16) = K(16,1) * [MAPK1_p] * [RPS6KA3] -K(16,2) * [MAPK1_p \|RPS6KA3];
R17	MAPK1_p \|RPS6KA3	MAPK1_p + RPS6KA3_p	MAPK1_p \|RPS6KA3 → MAPK1_p + RPS6KA3_p	V(17) = K(17,1) * [MAPK1_p \|RPS6KA3];
R18	CTNNB1 + PRKCA_p	PRKCA_p \|CTNNB1	CTNNB1 + PRKCA_p → PRKCA_p \|CTNNB1	V(18) = K(18,1) * [PRKCA_p] * [CTNNB1] -K(18,2) * [PRKCA_p \|CTNNB1];
R19	PRKCA_p \|CTNNB1	CTNNB1_p + PRKCA_p	PRKCA_p \|CTNNB1 → CTNNB1_p + PRKCA_p	V(19) = K(19,1) * [PRKCA_p \|CTNNB1];
R20	MAPK1_p + SMAD1	MAPK1_p \|SMAD1	MAPK1_p + SMAD1 → MAPK1_p \|SMAD1	V(20) = K(20,1) * [MAPK1_p] * [SMAD1] -K(20,2) * [MAPK1_p \|SMAD1];
R21	MAPK1_p \|SMAD1	MAPK1_p + SMAD1_p	MAPK1_p \|SMAD1 → MAPK1_p + SMAD1_p	V(21) = K(21,1) * [MAPK1_p \|SMAD1];
R22	PRKCZ_p + SP1	PRKCZ_p \|SP1	PRKCZ_p + SP1 → PRKCZ_p \|SP1	V(22) = K(22,1) * [PRKCZ_p] * [SP1] -K(22,2) * [PRKCZ_p \|SP1];
R23	PRKCZ_p \|SP1	PRKCZ_p + SP1_p	PRKCZ_p \|SP1 → PRKCZ_p + SP1_p	V(23) = K(23,1) * [PRKCZ_p \|SP1];
R24	PRKCZ_p + SNAI1	PRKCZ_p \|SNAI1	PRKCZ_p + SNAI1 → PRKCZ_p \|SNAI1	V(24) = K(24,1) * [PRKCZ_p] * [SNAI1] -K(24,2) * [PRKCZ_p \|SNAI1];
R25	PRKCZ_p \|SNAI1	PRKCZ_p + SNAI1_p	PRKCZ_p \|SNAI1 → PRKCZ_p + SNAI1_p	V(25) = K(25,1) * [PRKCZ_p \|SNAI1];
R26	EGFR + EGFR_p	EGFR_p \|EGFR	EGFR + EGFR_p → EGFR_p \|EGFR	V(26) = K(26,1) * [EGFR_p] * [EGFR] -K(26,2) * [EGFR_p \|EGFR];
R27	EGFR_p \|EGFR	EGFR_p + EGFR_p	EGFR_p \|EGFR → EGFR_p + EGFR_p	V(27) = K(27,1) * [EGFR_p \|EGFR];
R28	IKBKB + IKBKB_p	IKBKB_p \|IKBKB	IKBKB + IKBKB_p → IKBKB_p \|IKBKB	V(28) = K(28,1) * [IKBKB_p] * [IKBKB] -K(28,2) * [IKBKB_p \|IKBKB];
R29	IKBKB_p \|IKBKB	IKBKB_p + IKBKB_p	IKBKB_p \|IKBKB → IKBKB_p + IKBKB_p	V(29) = K(29,1) * [IKBKB_p \|IKBKB];
R30	PRKCA_p + VIM	PRKCA_p \|VIM	PRKCA_p + VIM → PRKCA_p \|VIM	V(30) = K(30,1) * [PRKCA_p] * [VIM] -K(30,2) * [PRKCA_p \|VIM];
R31	PRKCA_p \|VIM	PRKCA_p + VIM_p	PRKCA_p \|VIM → PRKCA_p + VIM_p	V(31) = K(31,1) * [PRKCA_p \|VIM];
R32	MAPK1_p + SMAD4	MAPK1_p \|SMAD4	MAPK1_p + SMAD4 → MAPK1_p \|SMAD4	V(32) = K(32,1) * [MAPK1_p] * [SMAD4] -K(32,2) * [MAPK1_p \|SMAD4];
R33	MAPK1_p \|SMAD4	MAPK1_p + SMAD4_p	MAPK1_p \|SMAD4 → MAPK1_p + SMAD4_p	V(33) = K(33,1) * [MAPK1_p \|SMAD4];
R34	MAPK1_p + STK11	MAPK1_p \|STK11	MAPK1_p + STK11 → MAPK1_p \|STK11	V(34) = K(34,1) * [MAPK1_p] * [STK11] -K(34,2) * [MAPK1_p \|STK11];
R35	MAPK1_p \|STK11	MAPK1_p + STK11_p	MAPK1_p \|STK11 → MAPK1_p + STK11_p	V(35) = K(35,1) * [MAPK1_p \|STK11];
R36	JUN + MAPK1_p	MAPK1_p \|JUN	JUN + MAPK1_p → MAPK1_p \|JUN	V(36) = K(36,1) * [MAPK1_p] * [JUN] -K(36,2) * [MAPK1_p \|JUN];
R37	MAPK1_p \|JUN	JUN_p + MAPK1_p	MAPK1_p \|JUN → JUN_p + MAPK1_p	V(37) = K(37,1) * [MAPK1_p \|JUN];
R38	IRS1 + MAPK8_p	MAPK8_p \|IRS1	IRS1 + MAPK8_p → MAPK8_p \|IRS1	V(38) = K(38,1) * [MAPK8_p] * [IRS1] -K(38,2) * [MAPK8_p \|IRS1];
R39	MAPK8_p \|IRS1	IRS1_p + MAPK8_p	MAPK8_p \|IRS1 → IRS1_p + MAPK8_p	V(39) = K(39,1) * [MAPK8_p \|IRS1];
R40	FOS + MAPK1_p	MAPK1_p \|FOS	FOS + MAPK1_p → MAPK1_p \|FOS	V(40) = K(40,1) * [MAPK1_p] * [FOS] -K(40,2) * [MAPK1_p \|FOS];
R41	MAPK1_p \|FOS	FOS_p + MAPK1_p	MAPK1_p \|FOS → FOS_p + MAPK1_p	V(41) = K(41,1) * [MAPK1_p \|FOS];
R42	EGFR + PRKCA_p	PRKCA_p \|EGFR	EGFR + PRKCA_p → PRKCA_p \|EGFR	V(42) = K(42,1) * [PRKCA_p] * [EGFR] -K(42,2) * [PRKCA_p \|EGFR];
R43	PRKCA_p \|EGFR	EGFR_p + PRKCA_p	PRKCA_p \|EGFR → EGFR_p + PRKCA_p	V(43) = K(43,1) * [PRKCA_p \|EGFR];
R44	STK11 + STK11_p	STK11_p \|STK11	STK11 + STK11_p → STK11_p \|STK11	V(44) = K(44,1) * [STK11_p] * [STK11] -K(44,2) * [STK11_p \|STK11];
R45	STK11_p \|STK11	STK11_p + STK11_p	STK11_p \|STK11 → STK11_p + STK11_p	V(45) = K(45,1) * [STK11_p \|STK11];
R46	KDR + KDR_p	KDR_p \|KDR	KDR + KDR_p → KDR_p \|KDR	V(46) = K(46,1) * [KDR_p] * [KDR] -K(46,2) * [KDR_p \|KDR];
R47	KDR_p \|KDR	KDR_p + KDR_p	KDR_p \|KDR → KDR_p + KDR_p	V(47) = K(47,1) * [KDR_p \|KDR];
R48	BCL2 + MAPK8_p	MAPK8_p \|BCL2	BCL2 + MAPK8_p → MAPK8_p \|BCL2	V(48) = K(48,1) * [MAPK8_p] * [BCL2] -K(48,2) * [MAPK8_p \|BCL2];
R49	MAPK8_p \|BCL2	BCL2_p + MAPK8_p	MAPK8_p \|BCL2 → BCL2_p + MAPK8_p	V(49) = K(49,1) * [MAPK8_p \|BCL2];
R50	MAPK9_p + TP53	MAPK9_p \|TP53	MAPK9_p + TP53 → MAPK9_p \|TP53	V(50) = K(50,1) * [MAPK9_p] * [TP53] -K(50,2) * [MAPK9_p \|TP53];
R51	MAPK9_p \|TP53	MAPK9_p + TP53_p	MAPK9_p \|TP53 → MAPK9_p + TP53_p	V(51) = K(51,1) * [MAPK9_p \|TP53];
R52	MAPK1_p + SMAD2	MAPK1_p \|SMAD2	MAPK1_p + SMAD2 → MAPK1_p \|SMAD2	V(52) = K(52,1) * [MAPK1_p] * [SMAD2] -K(52,2) * [MAPK1_p \|SMAD2];
R53	MAPK1_p \|SMAD2	MAPK1_p + SMAD2_p	MAPK1_p \|SMAD2 → MAPK1_p + SMAD2_p	V(53) = K(53,1) * [MAPK1_p \|SMAD2];
R54	CTNNB1 + KIT_p	KIT_p \|CTNNB1	CTNNB1 + KIT_p → KIT_p \|CTNNB1	V(54) = K(54,1) * [KIT_p] * [CTNNB1] -K(54,2) * [KIT_p \|CTNNB1];
R55	KIT_p \|CTNNB1	CTNNB1_p + KIT_p	KIT_p \|CTNNB1 → CTNNB1_p + KIT_p	V(55) = K(55,1) * [KIT_p \|CTNNB1];
R56	MAPK1_p + RORA	MAPK1_p \|RORA	MAPK1_p + RORA → MAPK1_p \|RORA	V(56) = K(56,1) * [MAPK1_p] * [RORA] -K(56,2) * [MAPK1_p \|RORA];
R57	MAPK1_p \|RORA	MAPK1_p + RORA_p	MAPK1_p \|RORA → MAPK1_p + RORA_p	V(57) = K(57,1) * [MAPK1_p \|RORA];
R58	JUN + MAPK9_p	MAPK9_p \|JUN	JUN + MAPK9_p → MAPK9_p \|JUN	V(58) = K(58,1) * [MAPK9_p] * [JUN] -K(58,2) * [MAPK9_p \|JUN];
R59	MAPK9_p \|JUN	JUN_p + MAPK9_p	MAPK9_p \|JUN → JUN_p + MAPK9_p	V(59) = K(59,1) * [MAPK9_p \|JUN];
R60	BCL2 + MAPK1_p	MAPK1_p \|BCL2	BCL2 + MAPK1_p → MAPK1_p \|BCL2	V(60) = K(60,1) * [MAPK1_p] * [BCL2] -K(60,2) * [MAPK1_p \|BCL2];
R61	MAPK1_p \|BCL2	BCL2_p + MAPK1_p	MAPK1_p \|BCL2 → BCL2_p + MAPK1_p	V(61) = K(61,1) * [MAPK1_p \|BCL2];
R62	INSR + INSR_p	INSR_p \|INSR	INSR + INSR_p → INSR_p \|INSR	V(62) = K(62,1) * [INSR_p] * [INSR] -K(62,2) * [INSR_p \|INSR];
R63	INSR_p \|INSR	INSR_p + INSR_p	INSR_p \|INSR → INSR_p + INSR_p	V(63) = K(63,1) * [INSR_p \|INSR];
R64	GJA1 + MAPK1_p	MAPK1_p \|GJA1	GJA1 + MAPK1_p → MAPK1_p \|GJA1	V(64) = K(64,1) * [MAPK1_p] * [GJA1] -K(64,2) * [MAPK1_p \|GJA1];
R65	MAPK1_p \|GJA1	GJA1_p + MAPK1_p	MAPK1_p \|GJA1 → GJA1_p + MAPK1_p	V(65) = K(65,1) * [MAPK1_p \|GJA1];
R66	INSR_p + IRS1	INSR_p \|IRS1	INSR_p + IRS1 → INSR_p \|IRS1	V(66) = K(66,1) * [INSR_p] * [IRS1] -K(66,2) * [INSR_p \|IRS1];
R67	INSR_p \|IRS1	INSR_p + IRS1_p	INSR_p \|IRS1 → INSR_p + IRS1_p	V(67) = K(67,1) * [INSR_p \|IRS1];
R68	MAPK1_p + SREBF1	MAPK1_p \|SREBF1	MAPK1_p + SREBF1 → MAPK1_p \|SREBF1	V(68) = K(68,1) * [MAPK1_p] * [SREBF1] -K(68,2) * [MAPK1_p \|SREBF1];
R69	MAPK1_p \|SREBF1	MAPK1_p + SREBF1_p	MAPK1_p \|SREBF1 → MAPK1_p + SREBF1_p	V(69) = K(69,1) * [MAPK1_p \|SREBF1];
R70	DUSP1 + MAPK1_p	MAPK1_p \|DUSP1	DUSP1 + MAPK1_p → MAPK1_p \|DUSP1	V(70) = K(70,1) * [MAPK1_p] * [DUSP1] -K(70,2) * [MAPK1_p \|DUSP1];
R71	MAPK1_p \|DUSP1	DUSP1_p + MAPK1_p	MAPK1_p \|DUSP1 → DUSP1_p + MAPK1_p	V(71) = K(71,1) * [MAPK1_p \|DUSP1];
R72	MAPK1_p + NR3C2	MAPK1_p \|NR3C2	MAPK1_p + NR3C2 → MAPK1_p \|NR3C2	V(72) = K(72,1) * [MAPK1_p] * [NR3C2] -K(72,2) * [MAPK1_p \|NR3C2];
R73	MAPK1_p \|NR3C2	MAPK1_p + NR3C2_p	MAPK1_p \|NR3C2 → MAPK1_p + NR3C2_p	V(73) = K(73,1) * [MAPK1_p \|NR3C2];
R74	HMGN1 + RPS6KA3_p	RPS6KA3_p \|HMGN1	HMGN1 + RPS6KA3_p → RPS6KA3_p \|HMGN1	V(74) = K(74,1) * [RPS6KA3_p] * [HMGN1] -K(74,2) * [RPS6KA3_p \|HMGN1];
R75	RPS6KA3_p \|HMGN1	HMGN1_p + RPS6KA3_p	RPS6KA3_p \|HMGN1 → HMGN1_p + RPS6KA3_p	V(75) = K(75,1) * [RPS6KA3_p \|HMGN1];
R76	PKN1 + PKN1_p	PKN1_p \|PKN1	PKN1 + PKN1_p → PKN1_p \|PKN1	V(76) = K(76,1) * [PKN1_p] * [PKN1] -K(76,2) * [PKN1_p \|PKN1];
R77	PKN1_p \|PKN1	PKN1_p + PKN1_p	PKN1_p \|PKN1 → PKN1_p + PKN1_p	V(77) = K(77,1) * [PKN1_p \|PKN1];
R78	PRKAA1_p + SNAI1	PRKAA1_p \|SNAI1	PRKAA1_p + SNAI1 → PRKAA1_p \|SNAI1	V(78) = K(78,1) * [PRKAA1_p] * [SNAI1] -K(78,2) * [PRKAA1_p \|SNAI1];
R79	PRKAA1_p \|SNAI1	PRKAA1_p + SNAI1_p	PRKAA1_p \|SNAI1 → PRKAA1_p + SNAI1_p	V(79) = K(79,1) * [PRKAA1_p \|SNAI1];
R80	IKBKB_p + IRS1	IKBKB_p \|IRS1	IKBKB_p + IRS1 → IKBKB_p \|IRS1	V(80) = K(80,1) * [IKBKB_p] * [IRS1] -K(80,2) * [IKBKB_p \|IRS1];
R81	IKBKB_p \|IRS1	IKBKB_p + IRS1_p	IKBKB_p \|IRS1 → IKBKB_p + IRS1_p	V(81) = K(81,1) * [IKBKB_p \|IRS1];
R82	MAPK8_p + MAPK9	MAPK8_p \|MAPK9	MAPK8_p + MAPK9 → MAPK8_p \|MAPK9	V(82) = K(82,1) * [MAPK8_p] * [MAPK9] -K(82,2) * [MAPK8_p \|MAPK9];
R83	MAPK8_p \|MAPK9	MAPK8_p + MAPK9_p	MAPK8_p \|MAPK9 → MAPK8_p + MAPK9_p	V(83) = K(83,1) * [MAPK8_p \|MAPK9];
R84	MAPK8_p + TP53	MAPK8_p \|TP53	MAPK8_p + TP53 → MAPK8_p \|TP53	V(84) = K(84,1) * [MAPK8_p] * [TP53] -K(84,2) * [MAPK8_p \|TP53];
R85	MAPK8_p \|TP53	MAPK8_p + TP53_p	MAPK8_p \|TP53 → MAPK8_p + TP53_p	V(85) = K(85,1) * [MAPK8_p \|TP53];
R86	IRS1 + MAPK9_p	MAPK9_p \|IRS1	IRS1 + MAPK9_p → MAPK9_p \|IRS1	V(86) = K(86,1) * [MAPK9_p] * [IRS1] -K(86,2) * [MAPK9_p \|IRS1];
R87	MAPK9_p \|IRS1	IRS1_p + MAPK9_p	MAPK9_p \|IRS1 → IRS1_p + MAPK9_p	V(87) = K(87,1) * [MAPK9_p \|IRS1];
R88	KIT + KIT_p	KIT_p \|KIT	KIT + KIT_p → KIT_p \|KIT	V(88) = K(88,1) * [KIT_p] * [KIT] -K(88,2) * [KIT_p \|KIT];
R89	KIT_p \|KIT	KIT_p + KIT_p	KIT_p \|KIT → KIT_p + KIT_p	V(89) = K(89,1) * [KIT_p \|KIT];
R90	CALM1 + EGFR_p	EGFR_p \|CALM1	CALM1 + EGFR_p → EGFR_p \|CALM1	V(90) = K(90,1) * [EGFR_p] * [CALM1] -K(90,2) * [EGFR_p \|CALM1];
R91	EGFR_p \|CALM1	CALM1_p + EGFR_p	EGFR_p \|CALM1 → CALM1_p + EGFR_p	V(91) = K(91,1) * [EGFR_p \|CALM1];
R92	MAPK8_p + NR3C1	MAPK8_p \|NR3C1	MAPK8_p + NR3C1 → MAPK8_p \|NR3C1	V(92) = K(92,1) * [MAPK8_p] * [NR3C1] -K(92,2) * [MAPK8_p \|NR3C1];
R93	MAPK8_p \|NR3C1	MAPK8_p + NR3C1_p	MAPK8_p \|NR3C1 → MAPK8_p + NR3C1_p	V(93) = K(93,1) * [MAPK8_p \|NR3C1];
R94	PRKCA + PRKCA_p	PRKCA_p \|PRKCA	PRKCA + PRKCA_p → PRKCA_p \|PRKCA	V(94) = K(94,1) * [PRKCA_p] * [PRKCA] -K(94,2) * [PRKCA_p \|PRKCA];
R95	PRKCA_p \|PRKCA	PRKCA_p + PRKCA_p	PRKCA_p \|PRKCA → PRKCA_p + PRKCA_p	V(95) = K(95,1) * [PRKCA_p \|PRKCA];
R96	MAPK1_p + SMAD3	MAPK1_p \|SMAD3	MAPK1_p + SMAD3 → MAPK1_p \|SMAD3	V(96) = K(96,1) * [MAPK1_p] * [SMAD3] -K(96,2) * [MAPK1_p \|SMAD3];
R97	MAPK1_p \|SMAD3	MAPK1_p + SMAD3_p	MAPK1_p \|SMAD3 → MAPK1_p + SMAD3_p	V(97) = K(97,1) * [MAPK1_p \|SMAD3];
R98	MAPK1_p + TFEB	MAPK1_p \|TFEB	MAPK1_p + TFEB → MAPK1_p \|TFEB	V(98) = K(98,1) * [MAPK1_p] * [TFEB] -K(98,2) * [MAPK1_p \|TFEB];
R99	MAPK1_p \|TFEB	MAPK1_p + TFEB_p	MAPK1_p \|TFEB → MAPK1_p + TFEB_p	V(99) = K(99,1) * [MAPK1_p \|TFEB];
R100	HMGN1 + PRKCA_p	PRKCA_p \|HMGN1	HMGN1 + PRKCA_p → PRKCA_p \|HMGN1	V(100) = K(100,1) * [PRKCA_p] * [HMGN1] -K(100,2) * [PRKCA_p \|HMGN1];
R101	PRKCA_p \|HMGN1	HMGN1_p + PRKCA_p	PRKCA_p \|HMGN1 → HMGN1_p + PRKCA_p	V(101) = K(101,1) * [PRKCA_p \|HMGN1];
R102	CALM1 + INSR_p	INSR_p \|CALM1	CALM1 + INSR_p → INSR_p \|CALM1	V(102) = K(102,1) * [INSR_p] * [CALM1] -K(102,2) * [INSR_p \|CALM1];
R103	INSR_p \|CALM1	CALM1_p + INSR_p	INSR_p \|CALM1 → CALM1_p + INSR_p	V(103) = K(103,1) * [INSR_p \|CALM1];
R104	CDKN1A + PRKCA_p	PRKCA_p \|CDKN1A	CDKN1A + PRKCA_p → PRKCA_p \|CDKN1A	V(104) = K(104,1) * [PRKCA_p] * [CDKN1A] -K(104,2) * [PRKCA_p \|CDKN1A];
R105	PRKCA_p \|CDKN1A	CDKN1A_p + PRKCA_p	PRKCA_p \|CDKN1A → CDKN1A_p + PRKCA_p	V(105) = K(105,1) * [PRKCA_p \|CDKN1A];
R106	GJA1 + PRKCA_p	PRKCA_p \|GJA1	GJA1 + PRKCA_p → PRKCA_p \|GJA1	V(106) = K(106,1) * [PRKCA_p] * [GJA1] -K(106,2) * [PRKCA_p \|GJA1];
R107	PRKCA_p \|GJA1	GJA1_p + PRKCA_p	PRKCA_p \|GJA1 → GJA1_p + PRKCA_p	V(107) = K(107,1) * [PRKCA_p \|GJA1];
R108	DEPTOR + RPS6KA3_p	RPS6KA3_p \|DEPTOR	DEPTOR + RPS6KA3_p → RPS6KA3_p \|DEPTOR	V(108) = K(108,1) * [RPS6KA3_p] * [DEPTOR] -K(108,2) * [RPS6KA3_p \|DEPTOR];
R109	RPS6KA3_p \|DEPTOR	DEPTOR_p + RPS6KA3_p	RPS6KA3_p \|DEPTOR → DEPTOR_p + RPS6KA3_p	V(109) = K(109,1) * [RPS6KA3_p \|DEPTOR];
R110	KIT + PRKCA_p	PRKCA_p \|KIT	KIT + PRKCA_p → PRKCA_p \|KIT	V(110) = K(110,1) * [PRKCA_p] * [KIT] -K(110,2) * [PRKCA_p \|KIT];
R111	PRKCA_p \|KIT	KIT_p + PRKCA_p	PRKCA_p \|KIT → KIT_p + PRKCA_p	V(111) = K(111,1) * [PRKCA_p \|KIT];
R112	IRS1 + PRKCZ_p	PRKCZ_p \|IRS1	IRS1 + PRKCZ_p → PRKCZ_p \|IRS1	V(112) = K(112,1) * [PRKCZ_p] * [IRS1] -K(112,2) * [PRKCZ_p \|IRS1];
R113	PRKCZ_p \|IRS1	IRS1_p + PRKCZ_p	PRKCZ_p \|IRS1 → IRS1_p + PRKCZ_p	V(113) = K(113,1) * [PRKCZ_p \|IRS1];
R114	ATR + MDM2	ATR \|MDM2	ATR + MDM2 → ATR \|MDM2	V(114) = K(114,1) * [ATR] * [MDM2] -K(114,2) * [ATR \|MDM2];
R115	ATR \|MDM2	ATR + MDM2_p	ATR \|MDM2 → ATR + MDM2_p	V(115) = K(115,1) * [ATR \|MDM2];
R116	PRKCZ_p + YAP1	PRKCZ_p \|YAP1	PRKCZ_p + YAP1 → PRKCZ_p \|YAP1	V(116) = K(116,1) * [PRKCZ_p] * [YAP1] -K(116,2) * [PRKCZ_p \|YAP1];
R117	PRKCZ_p \|YAP1	PRKCZ_p + YAP1_p	PRKCZ_p \|YAP1 → PRKCZ_p + YAP1_p	V(117) = K(117,1) * [PRKCZ_p \|YAP1];
R118	MAPK1_p + SIGNOR-C154	MAPK1_p \|SIGNOR-C154	MAPK1_p + SIGNOR-C154 → MAPK1_p \|SIGNOR-C154	V(118) = K(118,1) * [MAPK1_p] * [SIGNOR-C154] -K(118,2) * [MAPK1_p \|SIGNOR-C154];
R119	MAPK1_p \|SIGNOR-C154	MAPK1_p + SIGNOR-C154_p	MAPK1_p \|SIGNOR-C154 → MAPK1_p + SIGNOR-C154_p	V(119) = K(119,1) * [MAPK1_p \|SIGNOR-C154];
R120	CTNNB1 + MAPK8_p	MAPK8_p \|CTNNB1	CTNNB1 + MAPK8_p → MAPK8_p \|CTNNB1	V(120) = K(120,1) * [MAPK8_p] * [CTNNB1] -K(120,2) * [MAPK8_p \|CTNNB1];
R121	MAPK8_p \|CTNNB1	CTNNB1_p + MAPK8_p	MAPK8_p \|CTNNB1 → CTNNB1_p + MAPK8_p	V(121) = K(121,1) * [MAPK8_p \|CTNNB1];
R122	PINK1 + UBC	PINK1 \|UBC	PINK1 + UBC → PINK1 \|UBC	V(122) = K(122,1) * [PINK1] * [UBC] -K(122,2) * [PINK1 \|UBC];
R123	PINK1 \|UBC	PINK1 + UBC_p	PINK1 \|UBC → PINK1 + UBC_p	V(123) = K(123,1) * [PINK1 \|UBC];
R124	MAPK1_p + PPARA	MAPK1_p \|PPARA	MAPK1_p + PPARA → MAPK1_p \|PPARA	V(124) = K(124,1) * [MAPK1_p] * [PPARA] -K(124,2) * [MAPK1_p \|PPARA];
R125	MAPK1_p \|PPARA	MAPK1_p + PPARA_p	MAPK1_p \|PPARA → MAPK1_p + PPARA_p	V(125) = K(125,1) * [MAPK1_p \|PPARA];
R126	PRKCZ_p + VIM	PRKCZ_p \|VIM	PRKCZ_p + VIM → PRKCZ_p \|VIM	V(126) = K(126,1) * [PRKCZ_p] * [VIM] -K(126,2) * [PRKCZ_p \|VIM];
R127	PRKCZ_p \|VIM	PRKCZ_p + VIM_p	PRKCZ_p \|VIM → PRKCZ_p + VIM_p	V(127) = K(127,1) * [PRKCZ_p \|VIM];
R128	PTEN + STK11_p	STK11_p \|PTEN	PTEN + STK11_p → STK11_p \|PTEN	V(128) = K(128,1) * [STK11_p] * [PTEN] -K(128,2) * [STK11_p \|PTEN];
R129	STK11_p \|PTEN	PTEN_p + STK11_p	STK11_p \|PTEN → PTEN_p + STK11_p	V(129) = K(129,1) * [STK11_p \|PTEN];
R130	CREB1 + RPS6KA3_p	RPS6KA3_p \|CREB1	CREB1 + RPS6KA3_p → RPS6KA3_p \|CREB1	V(130) = K(130,1) * [RPS6KA3_p] * [CREB1] -K(130,2) * [RPS6KA3_p \|CREB1];
R131	RPS6KA3_p \|CREB1	CREB1_p + RPS6KA3_p	RPS6KA3_p \|CREB1 → CREB1_p + RPS6KA3_p	V(131) = K(131,1) * [RPS6KA3_p \|CREB1];
R132	NOS3 + PRKAA1_p	PRKAA1_p \|NOS3	NOS3 + PRKAA1_p → PRKAA1_p \|NOS3	V(132) = K(132,1) * [PRKAA1_p] * [NOS3] -K(132,2) * [PRKAA1_p \|NOS3];
R133	PRKAA1_p \|NOS3	NOS3_p + PRKAA1_p	PRKAA1_p \|NOS3 → NOS3_p + PRKAA1_p	V(133) = K(133,1) * [PRKAA1_p \|NOS3];
R134	MAPK8_p + PKM	MAPK8_p \|PKM	MAPK8_p + PKM → MAPK8_p \|PKM	V(134) = K(134,1) * [MAPK8_p] * [PKM] -K(134,2) * [MAPK8_p \|PKM];
R135	MAPK8_p \|PKM	MAPK8_p + PKM_p	MAPK8_p \|PKM → MAPK8_p + PKM_p	V(135) = K(135,1) * [MAPK8_p \|PKM];
R136	PRKAA1 + PRKCA_p	PRKCA_p \|PRKAA1	PRKAA1 + PRKCA_p → PRKCA_p \|PRKAA1	V(136) = K(136,1) * [PRKCA_p] * [PRKAA1] -K(136,2) * [PRKCA_p \|PRKAA1];
R137	PRKCA_p \|PRKAA1	PRKAA1_p + PRKCA_p	PRKCA_p \|PRKAA1 → PRKAA1_p + PRKCA_p	V(137) = K(137,1) * [PRKCA_p \|PRKAA1];
R138	EGFR + MAPK1_p	MAPK1_p \|EGFR	EGFR + MAPK1_p → MAPK1_p \|EGFR	V(138) = K(138,1) * [MAPK1_p] * [EGFR] -K(138,2) * [MAPK1_p \|EGFR];
R139	MAPK1_p \|EGFR	EGFR_p + MAPK1_p	MAPK1_p \|EGFR → EGFR_p + MAPK1_p	V(139) = K(139,1) * [MAPK1_p \|EGFR];
R140	MAPK8_p + STAT6	MAPK8_p \|STAT6	MAPK8_p + STAT6 → MAPK8_p \|STAT6	V(140) = K(140,1) * [MAPK8_p] * [STAT6] -K(140,2) * [MAPK8_p \|STAT6];
R141	MAPK8_p \|STAT6	MAPK8_p + STAT6_p	MAPK8_p \|STAT6 → MAPK8_p + STAT6_p	V(141) = K(141,1) * [MAPK8_p \|STAT6];
R142	INSR + PRKCA_p	PRKCA_p \|INSR	INSR + PRKCA_p → PRKCA_p \|INSR	V(142) = K(142,1) * [PRKCA_p] * [INSR] -K(142,2) * [PRKCA_p \|INSR];
R143	PRKCA_p \|INSR	INSR_p + PRKCA_p	PRKCA_p \|INSR → INSR_p + PRKCA_p	V(143) = K(143,1) * [PRKCA_p \|INSR];
R144	PRKCZ + PRKCZ_p	PRKCZ_p \|PRKCZ	PRKCZ + PRKCZ_p → PRKCZ_p \|PRKCZ	V(144) = K(144,1) * [PRKCZ_p] * [PRKCZ] -K(144,2) * [PRKCZ_p \|PRKCZ];
R145	PRKCZ_p \|PRKCZ	PRKCZ_p + PRKCZ_p	PRKCZ_p \|PRKCZ → PRKCZ_p + PRKCZ_p	V(145) = K(145,1) * [PRKCZ_p \|PRKCZ];
R146	MAPK1_p + SP1	MAPK1_p \|SP1	MAPK1_p + SP1 → MAPK1_p \|SP1	V(146) = K(146,1) * [MAPK1_p] * [SP1] -K(146,2) * [MAPK1_p \|SP1];
R147	MAPK1_p \|SP1	MAPK1_p + SP1_p	MAPK1_p \|SP1 → MAPK1_p + SP1_p	V(147) = K(147,1) * [MAPK1_p \|SP1];
R148	CDKN1A + MAPK8_p	MAPK8_p \|CDKN1A	CDKN1A + MAPK8_p → MAPK8_p \|CDKN1A	V(148) = K(148,1) * [MAPK8_p] * [CDKN1A] -K(148,2) * [MAPK8_p \|CDKN1A];
R149	MAPK8_p \|CDKN1A	CDKN1A_p + MAPK8_p	MAPK8_p \|CDKN1A → CDKN1A_p + MAPK8_p	V(149) = K(149,1) * [MAPK8_p \|CDKN1A];
R150	PRKCZ_p + STK11	PRKCZ_p \|STK11	PRKCZ_p + STK11 → PRKCZ_p \|STK11	V(150) = K(150,1) * [PRKCZ_p] * [STK11] -K(150,2) * [PRKCZ_p \|STK11];
R151	PRKCZ_p \|STK11	PRKCZ_p + STK11_p	PRKCZ_p \|STK11 → PRKCZ_p + STK11_p	V(151) = K(151,1) * [PRKCZ_p \|STK11];
R152	MAPK1_p + STAT5A	MAPK1_p \|STAT5A	MAPK1_p + STAT5A → MAPK1_p \|STAT5A	V(152) = K(152,1) * [MAPK1_p] * [STAT5A] -K(152,2) * [MAPK1_p \|STAT5A];
R153	MAPK1_p \|STAT5A	MAPK1_p + STAT5A_p	MAPK1_p \|STAT5A → MAPK1_p + STAT5A_p	V(153) = K(153,1) * [MAPK1_p \|STAT5A];
R154	CDKN1A + MAPK1_p	MAPK1_p \|CDKN1A	CDKN1A + MAPK1_p → MAPK1_p \|CDKN1A	V(154) = K(154,1) * [MAPK1_p] * [CDKN1A] -K(154,2) * [MAPK1_p \|CDKN1A];
R155	MAPK1_p \|CDKN1A	CDKN1A_p + MAPK1_p	MAPK1_p \|CDKN1A → CDKN1A_p + MAPK1_p	V(155) = K(155,1) * [MAPK1_p \|CDKN1A];
R156	JUN + MAPK8_p	MAPK8_p \|JUN	JUN + MAPK8_p → MAPK8_p \|JUN	V(156) = K(156,1) * [MAPK8_p] * [JUN] -K(156,2) * [MAPK8_p \|JUN];
R157	MAPK8_p \|JUN	JUN_p + MAPK8_p	MAPK8_p \|JUN → JUN_p + MAPK8_p	V(157) = K(157,1) * [MAPK8_p \|JUN];
R158	HES1 + PRKCA_p	PRKCA_p \|HES1	HES1 + PRKCA_p → PRKCA_p \|HES1	V(158) = K(158,1) * [PRKCA_p] * [HES1] -K(158,2) * [PRKCA_p \|HES1];
R159	PRKCA_p \|HES1	HES1_p + PRKCA_p	PRKCA_p \|HES1 → HES1_p + PRKCA_p	V(159) = K(159,1) * [PRKCA_p \|HES1];
R160	MAPK8_p + YAP1	MAPK8_p \|YAP1	MAPK8_p + YAP1 → MAPK8_p \|YAP1	V(160) = K(160,1) * [MAPK8_p] * [YAP1] -K(160,2) * [MAPK8_p \|YAP1];
R161	MAPK8_p \|YAP1	MAPK8_p + YAP1_p	MAPK8_p \|YAP1 → MAPK8_p + YAP1_p	V(161) = K(161,1) * [MAPK8_p \|YAP1];
R162	SMAD4 + STK11_p	STK11_p \|SMAD4	SMAD4 + STK11_p → STK11_p \|SMAD4	V(162) = K(162,1) * [STK11_p] * [SMAD4] -K(162,2) * [STK11_p \|SMAD4];
R163	STK11_p \|SMAD4	SMAD4_p + STK11_p	STK11_p \|SMAD4 → SMAD4_p + STK11_p	V(163) = K(163,1) * [STK11_p \|SMAD4];
R164	ANXA1 + PRKCA_p	PRKCA_p \|ANXA1	ANXA1 + PRKCA_p → PRKCA_p \|ANXA1	V(164) = K(164,1) * [PRKCA_p] * [ANXA1] -K(164,2) * [PRKCA_p \|ANXA1];
R165	PRKCA_p \|ANXA1	ANXA1_p + PRKCA_p	PRKCA_p \|ANXA1 → ANXA1_p + PRKCA_p	V(165) = K(165,1) * [PRKCA_p \|ANXA1];
R166	MAPK8_p + SP1	MAPK8_p \|SP1	MAPK8_p + SP1 → MAPK8_p \|SP1	V(166) = K(166,1) * [MAPK8_p] * [SP1] -K(166,2) * [MAPK8_p \|SP1];
R167	MAPK8_p \|SP1	MAPK8_p + SP1_p	MAPK8_p \|SP1 → MAPK8_p + SP1_p	V(167) = K(167,1) * [MAPK8_p \|SP1];
R168	PLK2 + TP53	PLK2 \|TP53	PLK2 + TP53 → PLK2 \|TP53	V(168) = K(168,1) * [PLK2] * [TP53] -K(168,2) * [PLK2 \|TP53];
R169	PLK2 \|TP53	PLK2 + TP53_p	PLK2 \|TP53 → PLK2 + TP53_p	V(169) = K(169,1) * [PLK2 \|TP53];
R170	SMAD1 + SMAD4	SMAD1 \|SMAD4	SMAD1 + SMAD4 → SMAD1 \|SMAD4	V(170) = K(170,1) * [SMAD1] * [SMAD4] -K(170,2) * [SMAD1 \|SMAD4];
R171	SMAD1 \|SMAD4	SMAD1 + SMAD4_p	SMAD1 \|SMAD4 → SMAD1 + SMAD4_p	V(171) = K(171,1) * [SMAD1 \|SMAD4];
R172	FOS + RPS6KA3_p	RPS6KA3_p \|FOS	FOS + RPS6KA3_p → RPS6KA3_p \|FOS	V(172) = K(172,1) * [RPS6KA3_p] * [FOS] -K(172,2) * [RPS6KA3_p \|FOS];
R173	RPS6KA3_p \|FOS	FOS_p + RPS6KA3_p	RPS6KA3_p \|FOS → FOS_p + RPS6KA3_p	V(173) = K(173,1) * [RPS6KA3_p \|FOS];
R174	KIT_p + STAT1	KIT_p \|STAT1	KIT_p + STAT1 → KIT_p \|STAT1	V(174) = K(174,1) * [KIT_p] * [STAT1] -K(174,2) * [KIT_p \|STAT1];
R175	KIT_p \|STAT1	KIT_p + STAT1_p	KIT_p \|STAT1 → KIT_p + STAT1_p	V(175) = K(175,1) * [KIT_p \|STAT1];
R176	RPS6KA3 + RPS6KA3_p	RPS6KA3_p \|RPS6KA3	RPS6KA3 + RPS6KA3_p → RPS6KA3_p \|RPS6KA3	V(176) = K(176,1) * [RPS6KA3_p] * [RPS6KA3] -K(176,2) * [RPS6KA3_p \|RPS6KA3];
R177	RPS6KA3_p \|RPS6KA3	RPS6KA3_p + RPS6KA3_p	RPS6KA3_p \|RPS6KA3 → RPS6KA3_p + RPS6KA3_p	V(177) = K(177,1) * [RPS6KA3_p \|RPS6KA3];
R178	EP300 + PRKAA1_p	PRKAA1_p \|EP300	EP300 + PRKAA1_p → PRKAA1_p \|EP300	V(178) = K(178,1) * [PRKAA1_p] * [EP300] -K(178,2) * [PRKAA1_p \|EP300];
R179	PRKAA1_p \|EP300	EP300_p + PRKAA1_p	PRKAA1_p \|EP300 → EP300_p + PRKAA1_p	V(179) = K(179,1) * [PRKAA1_p \|EP300];
R180	IRS1 + MAPK1_p	MAPK1_p \|IRS1	IRS1 + MAPK1_p → MAPK1_p \|IRS1	V(180) = K(180,1) * [MAPK1_p] * [IRS1] -K(180,2) * [MAPK1_p \|IRS1];
R181	MAPK1_p \|IRS1	IRS1_p + MAPK1_p	MAPK1_p \|IRS1 → IRS1_p + MAPK1_p	V(181) = K(181,1) * [MAPK1_p \|IRS1];
R182	PRKAA1_p + SREBF1	PRKAA1_p \|SREBF1	PRKAA1_p + SREBF1 → PRKAA1_p \|SREBF1	V(182) = K(182,1) * [PRKAA1_p] * [SREBF1] -K(182,2) * [PRKAA1_p \|SREBF1];
R183	PRKAA1_p \|SREBF1	PRKAA1_p + SREBF1_p	PRKAA1_p \|SREBF1 → PRKAA1_p + SREBF1_p	V(183) = K(183,1) * [PRKAA1_p \|SREBF1];
R184	JUNB + MAPK8_p	MAPK8_p \|JUNB	JUNB + MAPK8_p → MAPK8_p \|JUNB	V(184) = K(184,1) * [MAPK8_p] * [JUNB] -K(184,2) * [MAPK8_p \|JUNB];
R185	MAPK8_p \|JUNB	JUNB_p + MAPK8_p	MAPK8_p \|JUNB → JUNB_p + MAPK8_p	V(185) = K(185,1) * [MAPK8_p \|JUNB];
R186	NR4A1 + RPS6KA3_p	RPS6KA3_p \|NR4A1	NR4A1 + RPS6KA3_p → RPS6KA3_p \|NR4A1	V(186) = K(186,1) * [RPS6KA3_p] * [NR4A1] -K(186,2) * [RPS6KA3_p \|NR4A1];
R187	RPS6KA3_p \|NR4A1	NR4A1_p + RPS6KA3_p	RPS6KA3_p \|NR4A1 → NR4A1_p + RPS6KA3_p	V(187) = K(187,1) * [RPS6KA3_p \|NR4A1];
R188	MAPK12_p + TP53	MAPK12_p \|TP53	MAPK12_p + TP53 → MAPK12_p \|TP53	V(188) = K(188,1) * [MAPK12_p] * [TP53] -K(188,2) * [MAPK12_p \|TP53];
R189	MAPK12_p \|TP53	MAPK12_p + TP53_p	MAPK12_p \|TP53 → MAPK12_p + TP53_p	V(189) = K(189,1) * [MAPK12_p \|TP53];
R190	STK11_p + YAP1	STK11_p \|YAP1	STK11_p + YAP1 → STK11_p \|YAP1	V(190) = K(190,1) * [STK11_p] * [YAP1] -K(190,2) * [STK11_p \|YAP1];
R191	STK11_p \|YAP1	STK11_p + YAP1_p	STK11_p \|YAP1 → STK11_p + YAP1_p	V(191) = K(191,1) * [STK11_p \|YAP1];
R192	MAPK1 + MAPK1_p	MAPK1_p \|MAPK1	MAPK1 + MAPK1_p → MAPK1_p \|MAPK1	V(192) = K(192,1) * [MAPK1_p] * [MAPK1] -K(192,2) * [MAPK1_p \|MAPK1];
R193	MAPK1_p \|MAPK1	MAPK1_p + MAPK1_p	MAPK1_p \|MAPK1 → MAPK1_p + MAPK1_p	V(193) = K(193,1) * [MAPK1_p \|MAPK1];
R194	MAPK8_p + SMAD3	MAPK8_p \|SMAD3	MAPK8_p + SMAD3 → MAPK8_p \|SMAD3	V(194) = K(194,1) * [MAPK8_p] * [SMAD3] -K(194,2) * [MAPK8_p \|SMAD3];
R195	MAPK8_p \|SMAD3	MAPK8_p + SMAD3_p	MAPK8_p \|SMAD3 → MAPK8_p + SMAD3_p	V(195) = K(195,1) * [MAPK8_p \|SMAD3];
R196	PKN1_p + SNAI1	PKN1_p \|SNAI1	PKN1_p + SNAI1 → PKN1_p \|SNAI1	V(196) = K(196,1) * [PKN1_p] * [SNAI1] -K(196,2) * [PKN1_p \|SNAI1];
R197	PKN1_p \|SNAI1	PKN1_p + SNAI1_p	PKN1_p \|SNAI1 → PKN1_p + SNAI1_p	V(197) = K(197,1) * [PKN1_p \|SNAI1];
R198	LYN + LYN_p	LYN_p \|LYN	LYN + LYN_p → LYN_p \|LYN	V(198) = K(198,1) * [LYN_p] * [LYN] -K(198,2) * [LYN_p \|LYN];
R199	LYN_p \|LYN	LYN_p + LYN_p	LYN_p \|LYN → LYN_p + LYN_p	V(199) = K(199,1) * [LYN_p \|LYN];

Reaction ID	Reactants	Products	Original Text	ODE Equations
R1	SMAD2_p + SMAD4_p	SIGNOR-C8	SMAD2_p + SMAD4_p → SIGNOR-C8	V(1) = K(1,1) * [SMAD2_p] * [SMAD4_p] -K(1,2) * [SIGNOR-C8];
R2	SMAD3_p + SMAD4_p	SIGNOR-C9	SMAD3_p + SMAD4_p → SIGNOR-C9	V(2) = K(2,1) * [SMAD4_p] * [SMAD3_p] -K(2,2) * [SIGNOR-C9];
R3	JUN_p + SMAD4_p	SIGNOR-C10	JUN_p + SMAD4_p → SIGNOR-C10	V(3) = K(3,1) * [SMAD4_p] * [JUN_p] -K(3,2) * [SIGNOR-C10];
R4	SP1_p + STAT3_p	SIGNOR-C74	SP1_p + STAT3_p → SIGNOR-C74	V(4) = K(4,1) * [STAT3_p] * [SP1_p] -K(4,2) * [SIGNOR-C74];
R5	NR3C1 + STAT5A_p	SIGNOR-C84	NR3C1 + STAT5A_p → SIGNOR-C84	V(5) = K(5,1) * [NR3C1] * [STAT5A_p] -K(5,2) * [SIGNOR-C84];
R6	SMAD1 + SMAD1 + SMAD4_p	SIGNOR-C85	SMAD1 + SMAD1 + SMAD4_p → SIGNOR-C85	V(6) = K(6,1) * [SMAD4_p] * [SMAD1] * [SMAD1] -K(6,2) * [SIGNOR-C85];
R7	JUN_p + SMAD3_p	SIGNOR-C86	JUN_p + SMAD3_p → SIGNOR-C86	V(7) = K(7,1) * [JUN_p] * [SMAD3_p] -K(7,2) * [SIGNOR-C86];
R8	STAT1_p + STAT3_p	SIGNOR-C118	STAT1_p + STAT3_p → SIGNOR-C118	V(8) = K(8,1) * [STAT1_p] * [STAT3_p] -K(8,2) * [SIGNOR-C118];
R9	FOS_p + FOS_p + FOS_p + FOS_p + JUN_p + JUN_p + JUN_p + JUN_p	SIGNOR-C154	FOS_p + FOS_p + FOS_p + FOS_p + JUN_p + JUN_p + JUN_p + JUN_p → SIGNOR-C154	V(9) = K(9,1) * [FOS_p] * [JUN_p] * [JUN_p] * [FOS_p] * [JUN_p] * [FOS_p] * [FOS_p] * [JUN_p] -K(9,2) * [SIGNOR-C154];
R10	SMAD2 + TGFBR1	TGFBR1 \|SMAD2	SMAD2 + TGFBR1 → TGFBR1 \|SMAD2	V(10) = K(10,1) * [TGFBR1] * [SMAD2] -K(10,2) * [TGFBR1 \|SMAD2];
R11	TGFBR1 \|SMAD2	SMAD2_p + TGFBR1	TGFBR1 \|SMAD2 → SMAD2_p + TGFBR1	V(11) = K(11,1) * [TGFBR1 \|SMAD2];
R12	EP300 + MAPK1_p	MAPK1_p \|EP300	EP300 + MAPK1_p → MAPK1_p \|EP300	V(12) = K(12,1) * [MAPK1_p] * [EP300] -K(12,2) * [MAPK1_p \|EP300];
R13	MAPK1_p \|EP300	EP300_p + MAPK1_p	MAPK1_p \|EP300 → EP300_p + MAPK1_p	V(13) = K(13,1) * [MAPK1_p \|EP300];
R14	MAPK1_p + NR3C1	MAPK1_p \|NR3C1	MAPK1_p + NR3C1 → MAPK1_p \|NR3C1	V(14) = K(14,1) * [MAPK1_p] * [NR3C1] -K(14,2) * [MAPK1_p \|NR3C1];
R15	MAPK1_p \|NR3C1	MAPK1_p + NR3C1_p	MAPK1_p \|NR3C1 → MAPK1_p + NR3C1_p	V(15) = K(15,1) * [MAPK1_p \|NR3C1];
R16	MAPK1_p + RPS6KA3	MAPK1_p \|RPS6KA3	MAPK1_p + RPS6KA3 → MAPK1_p \|RPS6KA3	V(16) = K(16,1) * [MAPK1_p] * [RPS6KA3] -K(16,2) * [MAPK1_p \|RPS6KA3];
R17	MAPK1_p \|RPS6KA3	MAPK1_p + RPS6KA3_p	MAPK1_p \|RPS6KA3 → MAPK1_p + RPS6KA3_p	V(17) = K(17,1) * [MAPK1_p \|RPS6KA3];
R18	CTNNB1 + PRKCA_p	PRKCA_p \|CTNNB1	CTNNB1 + PRKCA_p → PRKCA_p \|CTNNB1	V(18) = K(18,1) * [PRKCA_p] * [CTNNB1] -K(18,2) * [PRKCA_p \|CTNNB1];
R19	PRKCA_p \|CTNNB1	CTNNB1_p + PRKCA_p	PRKCA_p \|CTNNB1 → CTNNB1_p + PRKCA_p	V(19) = K(19,1) * [PRKCA_p \|CTNNB1];
R20	MAPK1_p + SMAD1	MAPK1_p \|SMAD1	MAPK1_p + SMAD1 → MAPK1_p \|SMAD1	V(20) = K(20,1) * [MAPK1_p] * [SMAD1] -K(20,2) * [MAPK1_p \|SMAD1];
R21	MAPK1_p \|SMAD1	MAPK1_p + SMAD1_p	MAPK1_p \|SMAD1 → MAPK1_p + SMAD1_p	V(21) = K(21,1) * [MAPK1_p \|SMAD1];
R22	PRKCZ_p + SP1	PRKCZ_p \|SP1	PRKCZ_p + SP1 → PRKCZ_p \|SP1	V(22) = K(22,1) * [PRKCZ_p] * [SP1] -K(22,2) * [PRKCZ_p \|SP1];
R23	PRKCZ_p \|SP1	PRKCZ_p + SP1_p	PRKCZ_p \|SP1 → PRKCZ_p + SP1_p	V(23) = K(23,1) * [PRKCZ_p \|SP1];
R24	PRKCZ_p + SNAI1	PRKCZ_p \|SNAI1	PRKCZ_p + SNAI1 → PRKCZ_p \|SNAI1	V(24) = K(24,1) * [PRKCZ_p] * [SNAI1] -K(24,2) * [PRKCZ_p \|SNAI1];
R25	PRKCZ_p \|SNAI1	PRKCZ_p + SNAI1_p	PRKCZ_p \|SNAI1 → PRKCZ_p + SNAI1_p	V(25) = K(25,1) * [PRKCZ_p \|SNAI1];
R26	EGFR + EGFR_p	EGFR_p \|EGFR	EGFR + EGFR_p → EGFR_p \|EGFR	V(26) = K(26,1) * [EGFR_p] * [EGFR] -K(26,2) * [EGFR_p \|EGFR];
R27	EGFR_p \|EGFR	EGFR_p + EGFR_p	EGFR_p \|EGFR → EGFR_p + EGFR_p	V(27) = K(27,1) * [EGFR_p \|EGFR];
R28	IKBKB + IKBKB_p	IKBKB_p \|IKBKB	IKBKB + IKBKB_p → IKBKB_p \|IKBKB	V(28) = K(28,1) * [IKBKB_p] * [IKBKB] -K(28,2) * [IKBKB_p \|IKBKB];
R29	IKBKB_p \|IKBKB	IKBKB_p + IKBKB_p	IKBKB_p \|IKBKB → IKBKB_p + IKBKB_p	V(29) = K(29,1) * [IKBKB_p \|IKBKB];
R30	PRKCA_p + VIM	PRKCA_p \|VIM	PRKCA_p + VIM → PRKCA_p \|VIM	V(30) = K(30,1) * [PRKCA_p] * [VIM] -K(30,2) * [PRKCA_p \|VIM];
R31	PRKCA_p \|VIM	PRKCA_p + VIM_p	PRKCA_p \|VIM → PRKCA_p + VIM_p	V(31) = K(31,1) * [PRKCA_p \|VIM];
R32	MAPK1_p + SMAD4	MAPK1_p \|SMAD4	MAPK1_p + SMAD4 → MAPK1_p \|SMAD4	V(32) = K(32,1) * [MAPK1_p] * [SMAD4] -K(32,2) * [MAPK1_p \|SMAD4];
R33	MAPK1_p \|SMAD4	MAPK1_p + SMAD4_p	MAPK1_p \|SMAD4 → MAPK1_p + SMAD4_p	V(33) = K(33,1) * [MAPK1_p \|SMAD4];
R34	MAPK1_p + STK11	MAPK1_p \|STK11	MAPK1_p + STK11 → MAPK1_p \|STK11	V(34) = K(34,1) * [MAPK1_p] * [STK11] -K(34,2) * [MAPK1_p \|STK11];
R35	MAPK1_p \|STK11	MAPK1_p + STK11_p	MAPK1_p \|STK11 → MAPK1_p + STK11_p	V(35) = K(35,1) * [MAPK1_p \|STK11];
R36	JUN + MAPK1_p	MAPK1_p \|JUN	JUN + MAPK1_p → MAPK1_p \|JUN	V(36) = K(36,1) * [MAPK1_p] * [JUN] -K(36,2) * [MAPK1_p \|JUN];
R37	MAPK1_p \|JUN	JUN_p + MAPK1_p	MAPK1_p \|JUN → JUN_p + MAPK1_p	V(37) = K(37,1) * [MAPK1_p \|JUN];
R38	IRS1 + MAPK8_p	MAPK8_p \|IRS1	IRS1 + MAPK8_p → MAPK8_p \|IRS1	V(38) = K(38,1) * [MAPK8_p] * [IRS1] -K(38,2) * [MAPK8_p \|IRS1];
R39	MAPK8_p \|IRS1	IRS1_p + MAPK8_p	MAPK8_p \|IRS1 → IRS1_p + MAPK8_p	V(39) = K(39,1) * [MAPK8_p \|IRS1];
R40	FOS + MAPK1_p	MAPK1_p \|FOS	FOS + MAPK1_p → MAPK1_p \|FOS	V(40) = K(40,1) * [MAPK1_p] * [FOS] -K(40,2) * [MAPK1_p \|FOS];
R41	MAPK1_p \|FOS	FOS_p + MAPK1_p	MAPK1_p \|FOS → FOS_p + MAPK1_p	V(41) = K(41,1) * [MAPK1_p \|FOS];
R42	EGFR + PRKCA_p	PRKCA_p \|EGFR	EGFR + PRKCA_p → PRKCA_p \|EGFR	V(42) = K(42,1) * [PRKCA_p] * [EGFR] -K(42,2) * [PRKCA_p \|EGFR];
R43	PRKCA_p \|EGFR	EGFR_p + PRKCA_p	PRKCA_p \|EGFR → EGFR_p + PRKCA_p	V(43) = K(43,1) * [PRKCA_p \|EGFR];
R44	STK11 + STK11_p	STK11_p \|STK11	STK11 + STK11_p → STK11_p \|STK11	V(44) = K(44,1) * [STK11_p] * [STK11] -K(44,2) * [STK11_p \|STK11];
R45	STK11_p \|STK11	STK11_p + STK11_p	STK11_p \|STK11 → STK11_p + STK11_p	V(45) = K(45,1) * [STK11_p \|STK11];
R46	KDR + KDR_p	KDR_p \|KDR	KDR + KDR_p → KDR_p \|KDR	V(46) = K(46,1) * [KDR_p] * [KDR] -K(46,2) * [KDR_p \|KDR];
R47	KDR_p \|KDR	KDR_p + KDR_p	KDR_p \|KDR → KDR_p + KDR_p	V(47) = K(47,1) * [KDR_p \|KDR];
R48	BCL2 + MAPK8_p	MAPK8_p \|BCL2	BCL2 + MAPK8_p → MAPK8_p \|BCL2	V(48) = K(48,1) * [MAPK8_p] * [BCL2] -K(48,2) * [MAPK8_p \|BCL2];
R49	MAPK8_p \|BCL2	BCL2_p + MAPK8_p	MAPK8_p \|BCL2 → BCL2_p + MAPK8_p	V(49) = K(49,1) * [MAPK8_p \|BCL2];
R50	MAPK9_p + TP53	MAPK9_p \|TP53	MAPK9_p + TP53 → MAPK9_p \|TP53	V(50) = K(50,1) * [MAPK9_p] * [TP53] -K(50,2) * [MAPK9_p \|TP53];
R51	MAPK9_p \|TP53	MAPK9_p + TP53_p	MAPK9_p \|TP53 → MAPK9_p + TP53_p	V(51) = K(51,1) * [MAPK9_p \|TP53];
R52	MAPK1_p + SMAD2	MAPK1_p \|SMAD2	MAPK1_p + SMAD2 → MAPK1_p \|SMAD2	V(52) = K(52,1) * [MAPK1_p] * [SMAD2] -K(52,2) * [MAPK1_p \|SMAD2];
R53	MAPK1_p \|SMAD2	MAPK1_p + SMAD2_p	MAPK1_p \|SMAD2 → MAPK1_p + SMAD2_p	V(53) = K(53,1) * [MAPK1_p \|SMAD2];
R54	CTNNB1 + KIT_p	KIT_p \|CTNNB1	CTNNB1 + KIT_p → KIT_p \|CTNNB1	V(54) = K(54,1) * [KIT_p] * [CTNNB1] -K(54,2) * [KIT_p \|CTNNB1];
R55	KIT_p \|CTNNB1	CTNNB1_p + KIT_p	KIT_p \|CTNNB1 → CTNNB1_p + KIT_p	V(55) = K(55,1) * [KIT_p \|CTNNB1];
R56	MAPK1_p + RORA	MAPK1_p \|RORA	MAPK1_p + RORA → MAPK1_p \|RORA	V(56) = K(56,1) * [MAPK1_p] * [RORA] -K(56,2) * [MAPK1_p \|RORA];
R57	MAPK1_p \|RORA	MAPK1_p + RORA_p	MAPK1_p \|RORA → MAPK1_p + RORA_p	V(57) = K(57,1) * [MAPK1_p \|RORA];
R58	JUN + MAPK9_p	MAPK9_p \|JUN	JUN + MAPK9_p → MAPK9_p \|JUN	V(58) = K(58,1) * [MAPK9_p] * [JUN] -K(58,2) * [MAPK9_p \|JUN];
R59	MAPK9_p \|JUN	JUN_p + MAPK9_p	MAPK9_p \|JUN → JUN_p + MAPK9_p	V(59) = K(59,1) * [MAPK9_p \|JUN];
R60	BCL2 + MAPK1_p	MAPK1_p \|BCL2	BCL2 + MAPK1_p → MAPK1_p \|BCL2	V(60) = K(60,1) * [MAPK1_p] * [BCL2] -K(60,2) * [MAPK1_p \|BCL2];
R61	MAPK1_p \|BCL2	BCL2_p + MAPK1_p	MAPK1_p \|BCL2 → BCL2_p + MAPK1_p	V(61) = K(61,1) * [MAPK1_p \|BCL2];
R62	INSR + INSR_p	INSR_p \|INSR	INSR + INSR_p → INSR_p \|INSR	V(62) = K(62,1) * [INSR_p] * [INSR] -K(62,2) * [INSR_p \|INSR];
R63	INSR_p \|INSR	INSR_p + INSR_p	INSR_p \|INSR → INSR_p + INSR_p	V(63) = K(63,1) * [INSR_p \|INSR];
R64	GJA1 + MAPK1_p	MAPK1_p \|GJA1	GJA1 + MAPK1_p → MAPK1_p \|GJA1	V(64) = K(64,1) * [MAPK1_p] * [GJA1] -K(64,2) * [MAPK1_p \|GJA1];
R65	MAPK1_p \|GJA1	GJA1_p + MAPK1_p	MAPK1_p \|GJA1 → GJA1_p + MAPK1_p	V(65) = K(65,1) * [MAPK1_p \|GJA1];
R66	INSR_p + IRS1	INSR_p \|IRS1	INSR_p + IRS1 → INSR_p \|IRS1	V(66) = K(66,1) * [INSR_p] * [IRS1] -K(66,2) * [INSR_p \|IRS1];
R67	INSR_p \|IRS1	INSR_p + IRS1_p	INSR_p \|IRS1 → INSR_p + IRS1_p	V(67) = K(67,1) * [INSR_p \|IRS1];
R68	MAPK1_p + SREBF1	MAPK1_p \|SREBF1	MAPK1_p + SREBF1 → MAPK1_p \|SREBF1	V(68) = K(68,1) * [MAPK1_p] * [SREBF1] -K(68,2) * [MAPK1_p \|SREBF1];
R69	MAPK1_p \|SREBF1	MAPK1_p + SREBF1_p	MAPK1_p \|SREBF1 → MAPK1_p + SREBF1_p	V(69) = K(69,1) * [MAPK1_p \|SREBF1];
R70	DUSP1 + MAPK1_p	MAPK1_p \|DUSP1	DUSP1 + MAPK1_p → MAPK1_p \|DUSP1	V(70) = K(70,1) * [MAPK1_p] * [DUSP1] -K(70,2) * [MAPK1_p \|DUSP1];
R71	MAPK1_p \|DUSP1	DUSP1_p + MAPK1_p	MAPK1_p \|DUSP1 → DUSP1_p + MAPK1_p	V(71) = K(71,1) * [MAPK1_p \|DUSP1];
R72	MAPK1_p + NR3C2	MAPK1_p \|NR3C2	MAPK1_p + NR3C2 → MAPK1_p \|NR3C2	V(72) = K(72,1) * [MAPK1_p] * [NR3C2] -K(72,2) * [MAPK1_p \|NR3C2];
R73	MAPK1_p \|NR3C2	MAPK1_p + NR3C2_p	MAPK1_p \|NR3C2 → MAPK1_p + NR3C2_p	V(73) = K(73,1) * [MAPK1_p \|NR3C2];
R74	HMGN1 + RPS6KA3_p	RPS6KA3_p \|HMGN1	HMGN1 + RPS6KA3_p → RPS6KA3_p \|HMGN1	V(74) = K(74,1) * [RPS6KA3_p] * [HMGN1] -K(74,2) * [RPS6KA3_p \|HMGN1];
R75	RPS6KA3_p \|HMGN1	HMGN1_p + RPS6KA3_p	RPS6KA3_p \|HMGN1 → HMGN1_p + RPS6KA3_p	V(75) = K(75,1) * [RPS6KA3_p \|HMGN1];
R76	PKN1 + PKN1_p	PKN1_p \|PKN1	PKN1 + PKN1_p → PKN1_p \|PKN1	V(76) = K(76,1) * [PKN1_p] * [PKN1] -K(76,2) * [PKN1_p \|PKN1];
R77	PKN1_p \|PKN1	PKN1_p + PKN1_p	PKN1_p \|PKN1 → PKN1_p + PKN1_p	V(77) = K(77,1) * [PKN1_p \|PKN1];
R78	PRKAA1_p + SNAI1	PRKAA1_p \|SNAI1	PRKAA1_p + SNAI1 → PRKAA1_p \|SNAI1	V(78) = K(78,1) * [PRKAA1_p] * [SNAI1] -K(78,2) * [PRKAA1_p \|SNAI1];
R79	PRKAA1_p \|SNAI1	PRKAA1_p + SNAI1_p	PRKAA1_p \|SNAI1 → PRKAA1_p + SNAI1_p	V(79) = K(79,1) * [PRKAA1_p \|SNAI1];
R80	IKBKB_p + IRS1	IKBKB_p \|IRS1	IKBKB_p + IRS1 → IKBKB_p \|IRS1	V(80) = K(80,1) * [IKBKB_p] * [IRS1] -K(80,2) * [IKBKB_p \|IRS1];
R81	IKBKB_p \|IRS1	IKBKB_p + IRS1_p	IKBKB_p \|IRS1 → IKBKB_p + IRS1_p	V(81) = K(81,1) * [IKBKB_p \|IRS1];
R82	MAPK8_p + MAPK9	MAPK8_p \|MAPK9	MAPK8_p + MAPK9 → MAPK8_p \|MAPK9	V(82) = K(82,1) * [MAPK8_p] * [MAPK9] -K(82,2) * [MAPK8_p \|MAPK9];
R83	MAPK8_p \|MAPK9	MAPK8_p + MAPK9_p	MAPK8_p \|MAPK9 → MAPK8_p + MAPK9_p	V(83) = K(83,1) * [MAPK8_p \|MAPK9];
R84	MAPK8_p + TP53	MAPK8_p \|TP53	MAPK8_p + TP53 → MAPK8_p \|TP53	V(84) = K(84,1) * [MAPK8_p] * [TP53] -K(84,2) * [MAPK8_p \|TP53];
R85	MAPK8_p \|TP53	MAPK8_p + TP53_p	MAPK8_p \|TP53 → MAPK8_p + TP53_p	V(85) = K(85,1) * [MAPK8_p \|TP53];
R86	IRS1 + MAPK9_p	MAPK9_p \|IRS1	IRS1 + MAPK9_p → MAPK9_p \|IRS1	V(86) = K(86,1) * [MAPK9_p] * [IRS1] -K(86,2) * [MAPK9_p \|IRS1];
R87	MAPK9_p \|IRS1	IRS1_p + MAPK9_p	MAPK9_p \|IRS1 → IRS1_p + MAPK9_p	V(87) = K(87,1) * [MAPK9_p \|IRS1];
R88	KIT + KIT_p	KIT_p \|KIT	KIT + KIT_p → KIT_p \|KIT	V(88) = K(88,1) * [KIT_p] * [KIT] -K(88,2) * [KIT_p \|KIT];
R89	KIT_p \|KIT	KIT_p + KIT_p	KIT_p \|KIT → KIT_p + KIT_p	V(89) = K(89,1) * [KIT_p \|KIT];
R90	CALM1 + EGFR_p	EGFR_p \|CALM1	CALM1 + EGFR_p → EGFR_p \|CALM1	V(90) = K(90,1) * [EGFR_p] * [CALM1] -K(90,2) * [EGFR_p \|CALM1];
R91	EGFR_p \|CALM1	CALM1_p + EGFR_p	EGFR_p \|CALM1 → CALM1_p + EGFR_p	V(91) = K(91,1) * [EGFR_p \|CALM1];
R92	MAPK8_p + NR3C1	MAPK8_p \|NR3C1	MAPK8_p + NR3C1 → MAPK8_p \|NR3C1	V(92) = K(92,1) * [MAPK8_p] * [NR3C1] -K(92,2) * [MAPK8_p \|NR3C1];
R93	MAPK8_p \|NR3C1	MAPK8_p + NR3C1_p	MAPK8_p \|NR3C1 → MAPK8_p + NR3C1_p	V(93) = K(93,1) * [MAPK8_p \|NR3C1];
R94	PRKCA + PRKCA_p	PRKCA_p \|PRKCA	PRKCA + PRKCA_p → PRKCA_p \|PRKCA	V(94) = K(94,1) * [PRKCA_p] * [PRKCA] -K(94,2) * [PRKCA_p \|PRKCA];
R95	PRKCA_p \|PRKCA	PRKCA_p + PRKCA_p	PRKCA_p \|PRKCA → PRKCA_p + PRKCA_p	V(95) = K(95,1) * [PRKCA_p \|PRKCA];
R96	MAPK1_p + SMAD3	MAPK1_p \|SMAD3	MAPK1_p + SMAD3 → MAPK1_p \|SMAD3	V(96) = K(96,1) * [MAPK1_p] * [SMAD3] -K(96,2) * [MAPK1_p \|SMAD3];
R97	MAPK1_p \|SMAD3	MAPK1_p + SMAD3_p	MAPK1_p \|SMAD3 → MAPK1_p + SMAD3_p	V(97) = K(97,1) * [MAPK1_p \|SMAD3];
R98	MAPK1_p + TFEB	MAPK1_p \|TFEB	MAPK1_p + TFEB → MAPK1_p \|TFEB	V(98) = K(98,1) * [MAPK1_p] * [TFEB] -K(98,2) * [MAPK1_p \|TFEB];
R99	MAPK1_p \|TFEB	MAPK1_p + TFEB_p	MAPK1_p \|TFEB → MAPK1_p + TFEB_p	V(99) = K(99,1) * [MAPK1_p \|TFEB];
R100	HMGN1 + PRKCA_p	PRKCA_p \|HMGN1	HMGN1 + PRKCA_p → PRKCA_p \|HMGN1	V(100) = K(100,1) * [PRKCA_p] * [HMGN1] -K(100,2) * [PRKCA_p \|HMGN1];
R101	PRKCA_p \|HMGN1	HMGN1_p + PRKCA_p	PRKCA_p \|HMGN1 → HMGN1_p + PRKCA_p	V(101) = K(101,1) * [PRKCA_p \|HMGN1];
R102	CALM1 + INSR_p	INSR_p \|CALM1	CALM1 + INSR_p → INSR_p \|CALM1	V(102) = K(102,1) * [INSR_p] * [CALM1] -K(102,2) * [INSR_p \|CALM1];
R103	INSR_p \|CALM1	CALM1_p + INSR_p	INSR_p \|CALM1 → CALM1_p + INSR_p	V(103) = K(103,1) * [INSR_p \|CALM1];
R104	CDKN1A + PRKCA_p	PRKCA_p \|CDKN1A	CDKN1A + PRKCA_p → PRKCA_p \|CDKN1A	V(104) = K(104,1) * [PRKCA_p] * [CDKN1A] -K(104,2) * [PRKCA_p \|CDKN1A];
R105	PRKCA_p \|CDKN1A	CDKN1A_p + PRKCA_p	PRKCA_p \|CDKN1A → CDKN1A_p + PRKCA_p	V(105) = K(105,1) * [PRKCA_p \|CDKN1A];
R106	GJA1 + PRKCA_p	PRKCA_p \|GJA1	GJA1 + PRKCA_p → PRKCA_p \|GJA1	V(106) = K(106,1) * [PRKCA_p] * [GJA1] -K(106,2) * [PRKCA_p \|GJA1];
R107	PRKCA_p \|GJA1	GJA1_p + PRKCA_p	PRKCA_p \|GJA1 → GJA1_p + PRKCA_p	V(107) = K(107,1) * [PRKCA_p \|GJA1];
R108	DEPTOR + RPS6KA3_p	RPS6KA3_p \|DEPTOR	DEPTOR + RPS6KA3_p → RPS6KA3_p \|DEPTOR	V(108) = K(108,1) * [RPS6KA3_p] * [DEPTOR] -K(108,2) * [RPS6KA3_p \|DEPTOR];
R109	RPS6KA3_p \|DEPTOR	DEPTOR_p + RPS6KA3_p	RPS6KA3_p \|DEPTOR → DEPTOR_p + RPS6KA3_p	V(109) = K(109,1) * [RPS6KA3_p \|DEPTOR];
R110	KIT + PRKCA_p	PRKCA_p \|KIT	KIT + PRKCA_p → PRKCA_p \|KIT	V(110) = K(110,1) * [PRKCA_p] * [KIT] -K(110,2) * [PRKCA_p \|KIT];
R111	PRKCA_p \|KIT	KIT_p + PRKCA_p	PRKCA_p \|KIT → KIT_p + PRKCA_p	V(111) = K(111,1) * [PRKCA_p \|KIT];
R112	IRS1 + PRKCZ_p	PRKCZ_p \|IRS1	IRS1 + PRKCZ_p → PRKCZ_p \|IRS1	V(112) = K(112,1) * [PRKCZ_p] * [IRS1] -K(112,2) * [PRKCZ_p \|IRS1];
R113	PRKCZ_p \|IRS1	IRS1_p + PRKCZ_p	PRKCZ_p \|IRS1 → IRS1_p + PRKCZ_p	V(113) = K(113,1) * [PRKCZ_p \|IRS1];
R114	ATR + MDM2	ATR \|MDM2	ATR + MDM2 → ATR \|MDM2	V(114) = K(114,1) * [ATR] * [MDM2] -K(114,2) * [ATR \|MDM2];
R115	ATR \|MDM2	ATR + MDM2_p	ATR \|MDM2 → ATR + MDM2_p	V(115) = K(115,1) * [ATR \|MDM2];
R116	PRKCZ_p + YAP1	PRKCZ_p \|YAP1	PRKCZ_p + YAP1 → PRKCZ_p \|YAP1	V(116) = K(116,1) * [PRKCZ_p] * [YAP1] -K(116,2) * [PRKCZ_p \|YAP1];
R117	PRKCZ_p \|YAP1	PRKCZ_p + YAP1_p	PRKCZ_p \|YAP1 → PRKCZ_p + YAP1_p	V(117) = K(117,1) * [PRKCZ_p \|YAP1];
R118	MAPK1_p + SIGNOR-C154	MAPK1_p \|SIGNOR-C154	MAPK1_p + SIGNOR-C154 → MAPK1_p \|SIGNOR-C154	V(118) = K(118,1) * [MAPK1_p] * [SIGNOR-C154] -K(118,2) * [MAPK1_p \|SIGNOR-C154];
R119	MAPK1_p \|SIGNOR-C154	MAPK1_p + SIGNOR-C154_p	MAPK1_p \|SIGNOR-C154 → MAPK1_p + SIGNOR-C154_p	V(119) = K(119,1) * [MAPK1_p \|SIGNOR-C154];
R120	CTNNB1 + MAPK8_p	MAPK8_p \|CTNNB1	CTNNB1 + MAPK8_p → MAPK8_p \|CTNNB1	V(120) = K(120,1) * [MAPK8_p] * [CTNNB1] -K(120,2) * [MAPK8_p \|CTNNB1];
R121	MAPK8_p \|CTNNB1	CTNNB1_p + MAPK8_p	MAPK8_p \|CTNNB1 → CTNNB1_p + MAPK8_p	V(121) = K(121,1) * [MAPK8_p \|CTNNB1];
R122	PINK1 + UBC	PINK1 \|UBC	PINK1 + UBC → PINK1 \|UBC	V(122) = K(122,1) * [PINK1] * [UBC] -K(122,2) * [PINK1 \|UBC];
R123	PINK1 \|UBC	PINK1 + UBC_p	PINK1 \|UBC → PINK1 + UBC_p	V(123) = K(123,1) * [PINK1 \|UBC];
R124	MAPK1_p + PPARA	MAPK1_p \|PPARA	MAPK1_p + PPARA → MAPK1_p \|PPARA	V(124) = K(124,1) * [MAPK1_p] * [PPARA] -K(124,2) * [MAPK1_p \|PPARA];
R125	MAPK1_p \|PPARA	MAPK1_p + PPARA_p	MAPK1_p \|PPARA → MAPK1_p + PPARA_p	V(125) = K(125,1) * [MAPK1_p \|PPARA];
R126	PRKCZ_p + VIM	PRKCZ_p \|VIM	PRKCZ_p + VIM → PRKCZ_p \|VIM	V(126) = K(126,1) * [PRKCZ_p] * [VIM] -K(126,2) * [PRKCZ_p \|VIM];
R127	PRKCZ_p \|VIM	PRKCZ_p + VIM_p	PRKCZ_p \|VIM → PRKCZ_p + VIM_p	V(127) = K(127,1) * [PRKCZ_p \|VIM];
R128	PTEN + STK11_p	STK11_p \|PTEN	PTEN + STK11_p → STK11_p \|PTEN	V(128) = K(128,1) * [STK11_p] * [PTEN] -K(128,2) * [STK11_p \|PTEN];
R129	STK11_p \|PTEN	PTEN_p + STK11_p	STK11_p \|PTEN → PTEN_p + STK11_p	V(129) = K(129,1) * [STK11_p \|PTEN];
R130	CREB1 + RPS6KA3_p	RPS6KA3_p \|CREB1	CREB1 + RPS6KA3_p → RPS6KA3_p \|CREB1	V(130) = K(130,1) * [RPS6KA3_p] * [CREB1] -K(130,2) * [RPS6KA3_p \|CREB1];
R131	RPS6KA3_p \|CREB1	CREB1_p + RPS6KA3_p	RPS6KA3_p \|CREB1 → CREB1_p + RPS6KA3_p	V(131) = K(131,1) * [RPS6KA3_p \|CREB1];
R132	NOS3 + PRKAA1_p	PRKAA1_p \|NOS3	NOS3 + PRKAA1_p → PRKAA1_p \|NOS3	V(132) = K(132,1) * [PRKAA1_p] * [NOS3] -K(132,2) * [PRKAA1_p \|NOS3];
R133	PRKAA1_p \|NOS3	NOS3_p + PRKAA1_p	PRKAA1_p \|NOS3 → NOS3_p + PRKAA1_p	V(133) = K(133,1) * [PRKAA1_p \|NOS3];
R134	MAPK8_p + PKM	MAPK8_p \|PKM	MAPK8_p + PKM → MAPK8_p \|PKM	V(134) = K(134,1) * [MAPK8_p] * [PKM] -K(134,2) * [MAPK8_p \|PKM];
R135	MAPK8_p \|PKM	MAPK8_p + PKM_p	MAPK8_p \|PKM → MAPK8_p + PKM_p	V(135) = K(135,1) * [MAPK8_p \|PKM];
R136	PRKAA1 + PRKCA_p	PRKCA_p \|PRKAA1	PRKAA1 + PRKCA_p → PRKCA_p \|PRKAA1	V(136) = K(136,1) * [PRKCA_p] * [PRKAA1] -K(136,2) * [PRKCA_p \|PRKAA1];
R137	PRKCA_p \|PRKAA1	PRKAA1_p + PRKCA_p	PRKCA_p \|PRKAA1 → PRKAA1_p + PRKCA_p	V(137) = K(137,1) * [PRKCA_p \|PRKAA1];
R138	EGFR + MAPK1_p	MAPK1_p \|EGFR	EGFR + MAPK1_p → MAPK1_p \|EGFR	V(138) = K(138,1) * [MAPK1_p] * [EGFR] -K(138,2) * [MAPK1_p \|EGFR];
R139	MAPK1_p \|EGFR	EGFR_p + MAPK1_p	MAPK1_p \|EGFR → EGFR_p + MAPK1_p	V(139) = K(139,1) * [MAPK1_p \|EGFR];
R140	MAPK8_p + STAT6	MAPK8_p \|STAT6	MAPK8_p + STAT6 → MAPK8_p \|STAT6	V(140) = K(140,1) * [MAPK8_p] * [STAT6] -K(140,2) * [MAPK8_p \|STAT6];
R141	MAPK8_p \|STAT6	MAPK8_p + STAT6_p	MAPK8_p \|STAT6 → MAPK8_p + STAT6_p	V(141) = K(141,1) * [MAPK8_p \|STAT6];
R142	INSR + PRKCA_p	PRKCA_p \|INSR	INSR + PRKCA_p → PRKCA_p \|INSR	V(142) = K(142,1) * [PRKCA_p] * [INSR] -K(142,2) * [PRKCA_p \|INSR];
R143	PRKCA_p \|INSR	INSR_p + PRKCA_p	PRKCA_p \|INSR → INSR_p + PRKCA_p	V(143) = K(143,1) * [PRKCA_p \|INSR];
R144	PRKCZ + PRKCZ_p	PRKCZ_p \|PRKCZ	PRKCZ + PRKCZ_p → PRKCZ_p \|PRKCZ	V(144) = K(144,1) * [PRKCZ_p] * [PRKCZ] -K(144,2) * [PRKCZ_p \|PRKCZ];
R145	PRKCZ_p \|PRKCZ	PRKCZ_p + PRKCZ_p	PRKCZ_p \|PRKCZ → PRKCZ_p + PRKCZ_p	V(145) = K(145,1) * [PRKCZ_p \|PRKCZ];
R146	MAPK1_p + SP1	MAPK1_p \|SP1	MAPK1_p + SP1 → MAPK1_p \|SP1	V(146) = K(146,1) * [MAPK1_p] * [SP1] -K(146,2) * [MAPK1_p \|SP1];
R147	MAPK1_p \|SP1	MAPK1_p + SP1_p	MAPK1_p \|SP1 → MAPK1_p + SP1_p	V(147) = K(147,1) * [MAPK1_p \|SP1];
R148	CDKN1A + MAPK8_p	MAPK8_p \|CDKN1A	CDKN1A + MAPK8_p → MAPK8_p \|CDKN1A	V(148) = K(148,1) * [MAPK8_p] * [CDKN1A] -K(148,2) * [MAPK8_p \|CDKN1A];
R149	MAPK8_p \|CDKN1A	CDKN1A_p + MAPK8_p	MAPK8_p \|CDKN1A → CDKN1A_p + MAPK8_p	V(149) = K(149,1) * [MAPK8_p \|CDKN1A];
R150	PRKCZ_p + STK11	PRKCZ_p \|STK11	PRKCZ_p + STK11 → PRKCZ_p \|STK11	V(150) = K(150,1) * [PRKCZ_p] * [STK11] -K(150,2) * [PRKCZ_p \|STK11];
R151	PRKCZ_p \|STK11	PRKCZ_p + STK11_p	PRKCZ_p \|STK11 → PRKCZ_p + STK11_p	V(151) = K(151,1) * [PRKCZ_p \|STK11];
R152	MAPK1_p + STAT5A	MAPK1_p \|STAT5A	MAPK1_p + STAT5A → MAPK1_p \|STAT5A	V(152) = K(152,1) * [MAPK1_p] * [STAT5A] -K(152,2) * [MAPK1_p \|STAT5A];
R153	MAPK1_p \|STAT5A	MAPK1_p + STAT5A_p	MAPK1_p \|STAT5A → MAPK1_p + STAT5A_p	V(153) = K(153,1) * [MAPK1_p \|STAT5A];
R154	CDKN1A + MAPK1_p	MAPK1_p \|CDKN1A	CDKN1A + MAPK1_p → MAPK1_p \|CDKN1A	V(154) = K(154,1) * [MAPK1_p] * [CDKN1A] -K(154,2) * [MAPK1_p \|CDKN1A];
R155	MAPK1_p \|CDKN1A	CDKN1A_p + MAPK1_p	MAPK1_p \|CDKN1A → CDKN1A_p + MAPK1_p	V(155) = K(155,1) * [MAPK1_p \|CDKN1A];
R156	JUN + MAPK8_p	MAPK8_p \|JUN	JUN + MAPK8_p → MAPK8_p \|JUN	V(156) = K(156,1) * [MAPK8_p] * [JUN] -K(156,2) * [MAPK8_p \|JUN];
R157	MAPK8_p \|JUN	JUN_p + MAPK8_p	MAPK8_p \|JUN → JUN_p + MAPK8_p	V(157) = K(157,1) * [MAPK8_p \|JUN];
R158	HES1 + PRKCA_p	PRKCA_p \|HES1	HES1 + PRKCA_p → PRKCA_p \|HES1	V(158) = K(158,1) * [PRKCA_p] * [HES1] -K(158,2) * [PRKCA_p \|HES1];
R159	PRKCA_p \|HES1	HES1_p + PRKCA_p	PRKCA_p \|HES1 → HES1_p + PRKCA_p	V(159) = K(159,1) * [PRKCA_p \|HES1];
R160	MAPK8_p + YAP1	MAPK8_p \|YAP1	MAPK8_p + YAP1 → MAPK8_p \|YAP1	V(160) = K(160,1) * [MAPK8_p] * [YAP1] -K(160,2) * [MAPK8_p \|YAP1];
R161	MAPK8_p \|YAP1	MAPK8_p + YAP1_p	MAPK8_p \|YAP1 → MAPK8_p + YAP1_p	V(161) = K(161,1) * [MAPK8_p \|YAP1];
R162	SMAD4 + STK11_p	STK11_p \|SMAD4	SMAD4 + STK11_p → STK11_p \|SMAD4	V(162) = K(162,1) * [STK11_p] * [SMAD4] -K(162,2) * [STK11_p \|SMAD4];
R163	STK11_p \|SMAD4	SMAD4_p + STK11_p	STK11_p \|SMAD4 → SMAD4_p + STK11_p	V(163) = K(163,1) * [STK11_p \|SMAD4];
R164	ANXA1 + PRKCA_p	PRKCA_p \|ANXA1	ANXA1 + PRKCA_p → PRKCA_p \|ANXA1	V(164) = K(164,1) * [PRKCA_p] * [ANXA1] -K(164,2) * [PRKCA_p \|ANXA1];
R165	PRKCA_p \|ANXA1	ANXA1_p + PRKCA_p	PRKCA_p \|ANXA1 → ANXA1_p + PRKCA_p	V(165) = K(165,1) * [PRKCA_p \|ANXA1];
R166	MAPK8_p + SP1	MAPK8_p \|SP1	MAPK8_p + SP1 → MAPK8_p \|SP1	V(166) = K(166,1) * [MAPK8_p] * [SP1] -K(166,2) * [MAPK8_p \|SP1];
R167	MAPK8_p \|SP1	MAPK8_p + SP1_p	MAPK8_p \|SP1 → MAPK8_p + SP1_p	V(167) = K(167,1) * [MAPK8_p \|SP1];
R168	PLK2 + TP53	PLK2 \|TP53	PLK2 + TP53 → PLK2 \|TP53	V(168) = K(168,1) * [PLK2] * [TP53] -K(168,2) * [PLK2 \|TP53];
R169	PLK2 \|TP53	PLK2 + TP53_p	PLK2 \|TP53 → PLK2 + TP53_p	V(169) = K(169,1) * [PLK2 \|TP53];
R170	SMAD1 + SMAD4	SMAD1 \|SMAD4	SMAD1 + SMAD4 → SMAD1 \|SMAD4	V(170) = K(170,1) * [SMAD1] * [SMAD4] -K(170,2) * [SMAD1 \|SMAD4];
R171	SMAD1 \|SMAD4	SMAD1 + SMAD4_p	SMAD1 \|SMAD4 → SMAD1 + SMAD4_p	V(171) = K(171,1) * [SMAD1 \|SMAD4];
R172	FOS + RPS6KA3_p	RPS6KA3_p \|FOS	FOS + RPS6KA3_p → RPS6KA3_p \|FOS	V(172) = K(172,1) * [RPS6KA3_p] * [FOS] -K(172,2) * [RPS6KA3_p \|FOS];
R173	RPS6KA3_p \|FOS	FOS_p + RPS6KA3_p	RPS6KA3_p \|FOS → FOS_p + RPS6KA3_p	V(173) = K(173,1) * [RPS6KA3_p \|FOS];
R174	KIT_p + STAT1	KIT_p \|STAT1	KIT_p + STAT1 → KIT_p \|STAT1	V(174) = K(174,1) * [KIT_p] * [STAT1] -K(174,2) * [KIT_p \|STAT1];
R175	KIT_p \|STAT1	KIT_p + STAT1_p	KIT_p \|STAT1 → KIT_p + STAT1_p	V(175) = K(175,1) * [KIT_p \|STAT1];
R176	RPS6KA3 + RPS6KA3_p	RPS6KA3_p \|RPS6KA3	RPS6KA3 + RPS6KA3_p → RPS6KA3_p \|RPS6KA3	V(176) = K(176,1) * [RPS6KA3_p] * [RPS6KA3] -K(176,2) * [RPS6KA3_p \|RPS6KA3];
R177	RPS6KA3_p \|RPS6KA3	RPS6KA3_p + RPS6KA3_p	RPS6KA3_p \|RPS6KA3 → RPS6KA3_p + RPS6KA3_p	V(177) = K(177,1) * [RPS6KA3_p \|RPS6KA3];
R178	EP300 + PRKAA1_p	PRKAA1_p \|EP300	EP300 + PRKAA1_p → PRKAA1_p \|EP300	V(178) = K(178,1) * [PRKAA1_p] * [EP300] -K(178,2) * [PRKAA1_p \|EP300];
R179	PRKAA1_p \|EP300	EP300_p + PRKAA1_p	PRKAA1_p \|EP300 → EP300_p + PRKAA1_p	V(179) = K(179,1) * [PRKAA1_p \|EP300];
R180	IRS1 + MAPK1_p	MAPK1_p \|IRS1	IRS1 + MAPK1_p → MAPK1_p \|IRS1	V(180) = K(180,1) * [MAPK1_p] * [IRS1] -K(180,2) * [MAPK1_p \|IRS1];
R181	MAPK1_p \|IRS1	IRS1_p + MAPK1_p	MAPK1_p \|IRS1 → IRS1_p + MAPK1_p	V(181) = K(181,1) * [MAPK1_p \|IRS1];
R182	PRKAA1_p + SREBF1	PRKAA1_p \|SREBF1	PRKAA1_p + SREBF1 → PRKAA1_p \|SREBF1	V(182) = K(182,1) * [PRKAA1_p] * [SREBF1] -K(182,2) * [PRKAA1_p \|SREBF1];
R183	PRKAA1_p \|SREBF1	PRKAA1_p + SREBF1_p	PRKAA1_p \|SREBF1 → PRKAA1_p + SREBF1_p	V(183) = K(183,1) * [PRKAA1_p \|SREBF1];
R184	JUNB + MAPK8_p	MAPK8_p \|JUNB	JUNB + MAPK8_p → MAPK8_p \|JUNB	V(184) = K(184,1) * [MAPK8_p] * [JUNB] -K(184,2) * [MAPK8_p \|JUNB];
R185	MAPK8_p \|JUNB	JUNB_p + MAPK8_p	MAPK8_p \|JUNB → JUNB_p + MAPK8_p	V(185) = K(185,1) * [MAPK8_p \|JUNB];
R186	NR4A1 + RPS6KA3_p	RPS6KA3_p \|NR4A1	NR4A1 + RPS6KA3_p → RPS6KA3_p \|NR4A1	V(186) = K(186,1) * [RPS6KA3_p] * [NR4A1] -K(186,2) * [RPS6KA3_p \|NR4A1];
R187	RPS6KA3_p \|NR4A1	NR4A1_p + RPS6KA3_p	RPS6KA3_p \|NR4A1 → NR4A1_p + RPS6KA3_p	V(187) = K(187,1) * [RPS6KA3_p \|NR4A1];
R188	MAPK12_p + TP53	MAPK12_p \|TP53	MAPK12_p + TP53 → MAPK12_p \|TP53	V(188) = K(188,1) * [MAPK12_p] * [TP53] -K(188,2) * [MAPK12_p \|TP53];
R189	MAPK12_p \|TP53	MAPK12_p + TP53_p	MAPK12_p \|TP53 → MAPK12_p + TP53_p	V(189) = K(189,1) * [MAPK12_p \|TP53];
R190	STK11_p + YAP1	STK11_p \|YAP1	STK11_p + YAP1 → STK11_p \|YAP1	V(190) = K(190,1) * [STK11_p] * [YAP1] -K(190,2) * [STK11_p \|YAP1];
R191	STK11_p \|YAP1	STK11_p + YAP1_p	STK11_p \|YAP1 → STK11_p + YAP1_p	V(191) = K(191,1) * [STK11_p \|YAP1];
R192	MAPK1 + MAPK1_p	MAPK1_p \|MAPK1	MAPK1 + MAPK1_p → MAPK1_p \|MAPK1	V(192) = K(192,1) * [MAPK1_p] * [MAPK1] -K(192,2) * [MAPK1_p \|MAPK1];
R193	MAPK1_p \|MAPK1	MAPK1_p + MAPK1_p	MAPK1_p \|MAPK1 → MAPK1_p + MAPK1_p	V(193) = K(193,1) * [MAPK1_p \|MAPK1];
R194	MAPK8_p + SMAD3	MAPK8_p \|SMAD3	MAPK8_p + SMAD3 → MAPK8_p \|SMAD3	V(194) = K(194,1) * [MAPK8_p] * [SMAD3] -K(194,2) * [MAPK8_p \|SMAD3];
R195	MAPK8_p \|SMAD3	MAPK8_p + SMAD3_p	MAPK8_p \|SMAD3 → MAPK8_p + SMAD3_p	V(195) = K(195,1) * [MAPK8_p \|SMAD3];
R196	PKN1_p + SNAI1	PKN1_p \|SNAI1	PKN1_p + SNAI1 → PKN1_p \|SNAI1	V(196) = K(196,1) * [PKN1_p] * [SNAI1] -K(196,2) * [PKN1_p \|SNAI1];
R197	PKN1_p \|SNAI1	PKN1_p + SNAI1_p	PKN1_p \|SNAI1 → PKN1_p + SNAI1_p	V(197) = K(197,1) * [PKN1_p \|SNAI1];
R198	LYN + LYN_p	LYN_p \|LYN	LYN + LYN_p → LYN_p \|LYN	V(198) = K(198,1) * [LYN_p] * [LYN] -K(198,2) * [LYN_p \|LYN];
R199	LYN_p \|LYN	LYN_p + LYN_p	LYN_p \|LYN → LYN_p + LYN_p	V(199) = K(199,1) * [LYN_p \|LYN];