Selected Cell
Cell:
Value:
PathwayEnrichmentResults_Top30
PathwayNetwork_Top30
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| id | geneSet | link | size | overlap | expect | enrichmentRatio | pValue | FDR | gene_count | genes |
| AKT phosphorylates targets in the cytosol | R-HSA-198323 | http://reactome.org/PathwayBrowser/#/R-HSA-198323 | 14 | 4 | 0.112764142897754 | 35.472268907563 | 3.69002405331553E-6 | 1.90651242754635E-4 | 4 | CASP9;CDKN1A;MDM2;TSC2 |
| Activation of BAD and translocation to mitochondria | R-HSA-111447 | http://reactome.org/PathwayBrowser/#/R-HSA-111447 | 15 | 3 | 0.120818724533308 | 24.8305882352941 | 2.13977333589188E-4 | 0.0041458108382905 | 3 | BCL2;YWHAB;YWHAZ |
| Activation of the AP-1 family of transcription factors | R-HSA-450341 | http://reactome.org/PathwayBrowser/#/R-HSA-450341 | 10 | 4 | 0.0805458163555387 | 49.6611764705882 | 7.93421368605606E-7 | 7.82503081662331E-5 | 4 | FOS;JUN;MAPK1;MAPK8 |
| BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | R-HSA-111453 | http://reactome.org/PathwayBrowser/#/R-HSA-111453 | 9 | 2 | 0.0724912347199848 | 27.5895424836601 | 0.0022250162428899 | 0.0241633929562253 | 2 | BCL2;STAT3 |
| CLEC7A/inflammasome pathway | R-HSA-5660668 | http://reactome.org/PathwayBrowser/#/R-HSA-5660668 | 6 | 2 | 0.0483274898133232 | 41.3843137254902 | 9.41786505028741E-4 | 0.0123518922390307 | 2 | NFKB1;PYCARD |
| DEx/H-box helicases activate type I IFN and inflammatory cytokines production | R-HSA-3134963 | http://reactome.org/PathwayBrowser/#/R-HSA-3134963 | 7 | 2 | 0.0563820714488771 | 35.472268907563 | 0.0013116027048574 | 0.0155297403595965 | 2 | MYD88;NFKB1 |
| Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | R-HSA-9027276 | http://reactome.org/PathwayBrowser/#/R-HSA-9027276 | 11 | 3 | 0.0886003979910926 | 33.8598930481283 | 7.94265786427939E-5 | 0.0018808655081383 | 3 | IRS2;PIK3CA;PIK3R1 |
| GAB1 signalosome | R-HSA-180292 | http://reactome.org/PathwayBrowser/#/R-HSA-180292 | 11 | 3 | 0.0886003979910926 | 33.8598930481283 | 7.94265786427939E-5 | 0.0018808655081383 | 3 | EGFR;PIK3CA;PIK3R1 |
| GP1b-IX-V activation signalling | R-HSA-430116 | http://reactome.org/PathwayBrowser/#/R-HSA-430116 | 12 | 3 | 0.0966549796266464 | 31.0382352941176 | 1.05286328758502E-4 | 0.0023014511606826 | 3 | FLNA;PIK3R1;YWHAZ |
| Growth hormone receptor signaling | R-HSA-982772 | http://reactome.org/PathwayBrowser/#/R-HSA-982772 | 24 | 6 | 0.193309959253292 | 31.0382352941176 | 2.73672416950532E-8 | 5.83264338625821E-6 | 6 | IRS2;MAPK1;SOCS1;SOCS3;STAT1;STAT3 |
| Interleukin-6 signaling | R-HSA-1059683 | http://reactome.org/PathwayBrowser/#/R-HSA-1059683 | 11 | 4 | 0.0886003979910926 | 45.1465240641711 | 1.23915444016908E-6 | 7.82503081662331E-5 | 4 | JAK1;SOCS3;STAT1;STAT3 |
| Interleukin-9 signaling | R-HSA-8985947 | http://reactome.org/PathwayBrowser/#/R-HSA-8985947 | 9 | 3 | 0.0724912347199848 | 41.3843137254902 | 4.09099413855029E-5 | 0.0011434663944636 | 3 | JAK1;STAT1;STAT3 |
| LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | R-HSA-3134973 | http://reactome.org/PathwayBrowser/#/R-HSA-3134973 | 5 | 2 | 0.0402729081777693 | 49.6611764705882 | 6.31161866618157E-4 | 0.009276991229172 | 2 | CTNNB1;EP300 |
| Loss of Function of SMAD2/3 in Cancer | R-HSA-3304349 | http://reactome.org/PathwayBrowser/#/R-HSA-3304349 | 7 | 2 | 0.0563820714488771 | 35.472268907563 | 0.0013116027048574 | 0.0155297403595965 | 2 | SMAD2;SMAD4 |
| MAPK1 (ERK2) activation | R-HSA-112411 | http://reactome.org/PathwayBrowser/#/R-HSA-112411 | 9 | 2 | 0.0724912347199848 | 27.5895424836601 | 0.0022250162428899 | 0.0241633929562253 | 2 | JAK1;MAPK1 |
| MET activates PI3K/AKT signaling | R-HSA-8851907 | http://reactome.org/PathwayBrowser/#/R-HSA-8851907 | 6 | 2 | 0.0483274898133232 | 41.3843137254902 | 9.41786505028741E-4 | 0.0123518922390307 | 2 | PIK3CA;PIK3R1 |
| PI3K/AKT activation | R-HSA-198203 | http://reactome.org/PathwayBrowser/#/R-HSA-198203 | 9 | 4 | 0.0724912347199848 | 55.1790849673202 | 4.78992517427556E-7 | 5.83344458724274E-5 | 4 | IRS2;PIK3CA;PIK3R1;RHOA |
| PTK6 Expression | R-HSA-8849473 | http://reactome.org/PathwayBrowser/#/R-HSA-8849473 | 5 | 2 | 0.0402729081777693 | 49.6611764705882 | 6.31161866618157E-4 | 0.009276991229172 | 2 | HIF1A;NR3C1 |
| PTK6 promotes HIF1A stabilization | R-HSA-8857538 | http://reactome.org/PathwayBrowser/#/R-HSA-8857538 | 6 | 2 | 0.0483274898133232 | 41.3843137254902 | 9.41786505028741E-4 | 0.0123518922390307 | 2 | EGFR;HIF1A |
| RUNX3 regulates CDKN1A transcription | R-HSA-8941855 | http://reactome.org/PathwayBrowser/#/R-HSA-8941855 | 7 | 2 | 0.0563820714488771 | 35.472268907563 | 0.0013116027048574 | 0.0155297403595965 | 2 | CDKN1A;SMAD4 |
| RUNX3 regulates WNT signaling | R-HSA-8951430 | http://reactome.org/PathwayBrowser/#/R-HSA-8951430 | 8 | 2 | 0.0644366530844309 | 31.0382352941176 | 0.001739659287 | 0.0195139413443096 | 2 | CCND1;CTNNB1 |
| RUNX3 regulates p14-ARF | R-HSA-8951936 | http://reactome.org/PathwayBrowser/#/R-HSA-8951936 | 9 | 2 | 0.0724912347199848 | 27.5895424836601 | 0.0022250162428899 | 0.0241633929562253 | 2 | CCND1;EP300 |
| Regulation of IFNG signaling | R-HSA-877312 | http://reactome.org/PathwayBrowser/#/R-HSA-877312 | 14 | 4 | 0.112764142897754 | 35.472268907563 | 3.69002405331553E-6 | 1.90651242754635E-4 | 4 | JAK1;SOCS1;SOCS3;STAT1 |
| Regulation of gene expression by Hypoxia-inducible Factor | R-HSA-1234158 | http://reactome.org/PathwayBrowser/#/R-HSA-1234158 | 11 | 3 | 0.0886003979910926 | 33.8598930481283 | 7.94265786427939E-5 | 0.0018808655081383 | 3 | EP300;HIF1A;VEGFA |
| Signal attenuation | R-HSA-74749 | http://reactome.org/PathwayBrowser/#/R-HSA-74749 | 10 | 2 | 0.0805458163555387 | 24.8305882352941 | 0.0027667446196928 | 0.028764021808392 | 2 | IRS2;MAPK1 |
| Signaling by Leptin | R-HSA-2586552 | http://reactome.org/PathwayBrowser/#/R-HSA-2586552 | 11 | 4 | 0.0886003979910926 | 45.1465240641711 | 1.23915444016908E-6 | 7.82503081662331E-5 | 4 | IRS2;LEPR;SOCS3;STAT3 |
| Signaling by cytosolic FGFR1 fusion mutants | R-HSA-1839117 | http://reactome.org/PathwayBrowser/#/R-HSA-1839117 | 18 | 4 | 0.144982469439969 | 27.5895424836601 | 1.10061368423508E-5 | 3.992651769406E-4 | 4 | PIK3CA;PIK3R1;STAT1;STAT3 |
| Tie2 Signaling | R-HSA-210993 | http://reactome.org/PathwayBrowser/#/R-HSA-210993 | 18 | 4 | 0.144982469439969 | 27.5895424836601 | 1.10061368423508E-5 | 3.992651769406E-4 | 4 | ANGPT1;PIK3CA;PIK3R1;TEK |
| VEGF ligand-receptor interactions | R-HSA-194313 | http://reactome.org/PathwayBrowser/#/R-HSA-194313 | 8 | 2 | 0.0644366530844309 | 31.0382352941176 | 0.001739659287 | 0.0195139413443096 | 2 | KDR;VEGFA |
| p75NTR signals via NF-kB | R-HSA-193639 | http://reactome.org/PathwayBrowser/#/R-HSA-193639 | 16 | 3 | 0.128873306168861 | 23.2786764705882 | 2.61827383339241E-4 | 0.0046501634228479 | 3 | MYD88;NFKB1;TRAF6 |
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| Note: Edges are drawn between pathways based on their common genes, and the edge width is based on the number of those genes. | |||||||||
