Selected Cell
Cell:
Value:
PathwayEnrichmentResults_Top30
PathwayNetwork_Top30
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| id | geneSet | link | size | overlap | expect | enrichmentRatio | pValue | FDR | gene_count | genes |
| Alternative complement activation | R-HSA-173736 | http://reactome.org/PathwayBrowser/#/R-HSA-173736 | 5 | 2 | 0.0450108973751539 | 44.4336842105263 | 7.87893055359534E-4 | 0.01343357659388 | 2 | C3;CFB |
| Apoptotic cleavage of cell adhesion proteins | R-HSA-351906 | http://reactome.org/PathwayBrowser/#/R-HSA-351906 | 11 | 2 | 0.0990239742253387 | 20.1971291866028 | 0.0041834016130943 | 0.045431208600802 | 2 | CDH1;CTNNB1 |
| CLEC7A/inflammasome pathway | R-HSA-5660668 | http://reactome.org/PathwayBrowser/#/R-HSA-5660668 | 6 | 2 | 0.0540130768501847 | 37.0280701754386 | 0.0011749087734836 | 0.0187216771849504 | 2 | NFKB1;PYCARD |
| Chylomicron clearance | R-HSA-8964026 | http://reactome.org/PathwayBrowser/#/R-HSA-8964026 | 5 | 2 | 0.0450108973751539 | 44.4336842105263 | 7.87893055359534E-4 | 0.01343357659388 | 2 | APOE;LDLR |
| Diseases of Immune System | R-HSA-5260271 | http://reactome.org/PathwayBrowser/#/R-HSA-5260271 | 24 | 4 | 0.216052307400739 | 18.5140350877193 | 5.70436978525323E-5 | 0.0019863457424018 | 4 | IKBKB;NFKB1;TLR3;TLR4 |
| Downregulation of SMAD2/3:SMAD4 transcriptional activity | R-HSA-2173795 | http://reactome.org/PathwayBrowser/#/R-HSA-2173795 | 23 | 4 | 0.207050127925708 | 19.3189931350114 | 4.78653873190459E-5 | 0.0018135663417549 | 4 | HDAC1;SMAD2;SMAD4;UBC |
| IkBA variant leads to EDA-ID | R-HSA-5603029 | http://reactome.org/PathwayBrowser/#/R-HSA-5603029 | 7 | 2 | 0.0630152563252155 | 31.7383458646616 | 0.0016352325414483 | 0.022853044944012 | 2 | IKBKB;NFKB1 |
| InlA-mediated entry of Listeria monocytogenes into host cells | R-HSA-8876493 | http://reactome.org/PathwayBrowser/#/R-HSA-8876493 | 9 | 3 | 0.0810196152752771 | 37.0280701754386 | 5.70855961159466E-5 | 0.0019863457424018 | 3 | CDH1;CTNNB1;UBC |
| Interleukin-27 signaling | R-HSA-9020956 | http://reactome.org/PathwayBrowser/#/R-HSA-9020956 | 11 | 3 | 0.0990239742253387 | 30.2956937799043 | 1.10673922745885E-4 | 0.003472502225245 | 3 | JAK1;JAK2;STAT1 |
| Interleukin-9 signaling | R-HSA-8985947 | http://reactome.org/PathwayBrowser/#/R-HSA-8985947 | 9 | 2 | 0.0810196152752771 | 24.685380116959 | 0.0027705282664296 | 0.0342300774946561 | 2 | JAK1;STAT1 |
| LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | R-HSA-3134973 | http://reactome.org/PathwayBrowser/#/R-HSA-3134973 | 5 | 2 | 0.0450108973751539 | 44.4336842105263 | 7.87893055359534E-4 | 0.01343357659388 | 2 | CTNNB1;IRF3 |
| Loss of Function of SMAD2/3 in Cancer | R-HSA-3304349 | http://reactome.org/PathwayBrowser/#/R-HSA-3304349 | 7 | 3 | 0.0630152563252155 | 47.6075187969924 | 2.40993535719491E-5 | 0.001141372162227 | 3 | SMAD2;SMAD4;TGFB1 |
| MAP3K8 (TPL2)-dependent MAPK1/3 activation | R-HSA-5684264 | http://reactome.org/PathwayBrowser/#/R-HSA-5684264 | 16 | 3 | 0.144034871600492 | 20.8282894736842 | 3.63540784429683E-4 | 0.0075589882616171 | 3 | IKBKB;NFKB1;UBC |
| MAPK1 (ERK2) activation | R-HSA-112411 | http://reactome.org/PathwayBrowser/#/R-HSA-112411 | 9 | 2 | 0.0810196152752771 | 24.685380116959 | 0.0027705282664296 | 0.0342300774946561 | 2 | JAK1;JAK2 |
| NF-kB is activated and signals survival | R-HSA-209560 | http://reactome.org/PathwayBrowser/#/R-HSA-209560 | 13 | 4 | 0.1170283331754 | 34.1797570850202 | 4.14120658276395E-6 | 3.53037861180627E-4 | 4 | IKBKB;IRAK1;NFKB1;UBC |
| RIP-mediated NFkB activation via ZBP1 | R-HSA-1810476 | http://reactome.org/PathwayBrowser/#/R-HSA-1810476 | 17 | 3 | 0.153037051075523 | 19.6030959752322 | 4.38569034495239E-4 | 0.0084972750433452 | 3 | IKBKB;NFKB1;TLR3 |
| RUNX3 regulates CDKN1A transcription | R-HSA-8941855 | http://reactome.org/PathwayBrowser/#/R-HSA-8941855 | 7 | 4 | 0.0630152563252155 | 63.4766917293233 | 2.11306497077679E-7 | 5.48220444209213E-5 | 4 | CDKN1A;SMAD4;TGFB1;TP53 |
| Regulation of IFNG signaling | R-HSA-877312 | http://reactome.org/PathwayBrowser/#/R-HSA-877312 | 14 | 4 | 0.126030512650431 | 31.7383458646616 | 5.75775525801791E-6 | 4.46226032496388E-4 | 4 | JAK1;JAK2;PTPN6;STAT1 |
| Regulation of PTEN localization | R-HSA-8948747 | http://reactome.org/PathwayBrowser/#/R-HSA-8948747 | 9 | 2 | 0.0810196152752771 | 24.685380116959 | 0.0027705282664296 | 0.0342300774946561 | 2 | PTEN;UBC |
| Regulation of gene expression by Hypoxia-inducible Factor | R-HSA-1234158 | http://reactome.org/PathwayBrowser/#/R-HSA-1234158 | 11 | 2 | 0.0990239742253387 | 20.1971291866028 | 0.0041834016130943 | 0.045431208600802 | 2 | HIF1A;VEGFA |
| SMAD2/3 Phosphorylation Motif Mutants in Cancer | R-HSA-3304356 | http://reactome.org/PathwayBrowser/#/R-HSA-3304356 | 6 | 2 | 0.0540130768501847 | 37.0280701754386 | 0.0011749087734836 | 0.0187216771849504 | 2 | SMAD2;TGFB1 |
| SUMOylation of intracellular receptors | R-HSA-4090294 | http://reactome.org/PathwayBrowser/#/R-HSA-4090294 | 30 | 6 | 0.270065384250923 | 22.2168421052631 | 2.2635411478511E-7 | 5.48220444209213E-5 | 6 | AR;ESR1;NR1H4;PPARA;RORA;VDR |
| Signaling by Leptin | R-HSA-2586552 | http://reactome.org/PathwayBrowser/#/R-HSA-2586552 | 11 | 2 | 0.0990239742253387 | 20.1971291866028 | 0.0041834016130943 | 0.045431208600802 | 2 | JAK2;LEPR |
| Syndecan interactions | R-HSA-3000170 | http://reactome.org/PathwayBrowser/#/R-HSA-3000170 | 27 | 5 | 0.243058845825831 | 20.5711500974658 | 3.66980138966077E-6 | 3.29316387861664E-4 | 5 | COL1A2;PRKCA;TGFB1;THBS1;TNC |
| TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | R-HSA-2173791 | http://reactome.org/PathwayBrowser/#/R-HSA-2173791 | 16 | 4 | 0.144034871600492 | 27.7710526315789 | 1.03249748506506E-5 | 6.5200304149479E-4 | 4 | PRKCZ;RHOA;TGFB1;UBC |
| TICAM1,TRAF6-dependent induction of TAK1 complex | R-HSA-9014325 | http://reactome.org/PathwayBrowser/#/R-HSA-9014325 | 17 | 3 | 0.153037051075523 | 19.6030959752322 | 4.38569034495239E-4 | 0.0084972750433452 | 3 | TLR3;TLR4;UBC |
| TICAM1-dependent activation of IRF3/IRF7 | R-HSA-9013973 | http://reactome.org/PathwayBrowser/#/R-HSA-9013973 | 12 | 3 | 0.108026153700369 | 27.7710526315789 | 1.46602937657891E-4 | 0.0042365764187577 | 3 | IRF3;TLR3;UBC |
| VEGFR2 mediated cell proliferation | R-HSA-5218921 | http://reactome.org/PathwayBrowser/#/R-HSA-5218921 | 21 | 5 | 0.189045768975646 | 26.4486215538847 | 9.65386093954023E-7 | 1.26614099245508E-4 | 5 | CALM1;PDPK1;PRKCA;PRKCZ;VEGFA |
| ZBP1(DAI) mediated induction of type I IFNs | R-HSA-1606322 | http://reactome.org/PathwayBrowser/#/R-HSA-1606322 | 21 | 4 | 0.189045768975646 | 21.1588972431077 | 3.28011798991223E-5 | 0.0013981502932 | 4 | IKBKB;IRF3;NFKB1;TLR3 |
| p75NTR recruits signalling complexes | R-HSA-209543 | http://reactome.org/PathwayBrowser/#/R-HSA-209543 | 13 | 3 | 0.1170283331754 | 25.6348178137651 | 1.89341456980463E-4 | 0.0049665720638721 | 3 | IKBKB;IRAK1;UBC |
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| Note: Edges are drawn between pathways based on their common genes, and the edge width is based on the number of those genes. | |||||||||
