Selected Cell
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PathwayEnrichmentResults_Top30
PathwayNetwork_Top30
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| id | geneSet | link | size | overlap | expect | enrichmentRatio | pValue | FDR | gene_count | genes |
| Activation of BAD and translocation to mitochondria | R-HSA-111447 | http://reactome.org/PathwayBrowser/#/R-HSA-111447 | 15 | 5 | 0.136454088884677 | 36.6423611111111 | 1.56733880096737E-7 | 1.06892506225975E-5 | 5 | AKT1;BAD;BCL2;YWHAB;YWHAZ |
| Activation of the AP-1 family of transcription factors | R-HSA-450341 | http://reactome.org/PathwayBrowser/#/R-HSA-450341 | 10 | 3 | 0.0909693925897849 | 32.978125 | 8.35903791940317E-5 | 0.0014252159652582 | 3 | FOS;JUN;MAPK1 |
| BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | R-HSA-111453 | http://reactome.org/PathwayBrowser/#/R-HSA-111453 | 9 | 3 | 0.0818724533308064 | 36.6423611111111 | 5.89018228029925E-5 | 0.0010780218149171 | 3 | BAD;BCL2;STAT3 |
| CLEC7A/inflammasome pathway | R-HSA-5660668 | http://reactome.org/PathwayBrowser/#/R-HSA-5660668 | 6 | 2 | 0.0545816355538709 | 36.6423611111111 | 0.0011996024559172 | 0.012222247686099 | 2 | NFKB1;PYCARD |
| Cross-presentation of particulate exogenous antigens (phagosomes) | R-HSA-1236973 | http://reactome.org/PathwayBrowser/#/R-HSA-1236973 | 8 | 2 | 0.0727755140718279 | 27.4817708333333 | 0.0022128178631305 | 0.0199621928922623 | 2 | CYBA;NCF1 |
| Growth hormone receptor signaling | R-HSA-982772 | http://reactome.org/PathwayBrowser/#/R-HSA-982772 | 24 | 7 | 0.218326542215483 | 32.0620659722222 | 1.26011845402729E-9 | 2.12414686950879E-7 | 7 | MAPK1;PTPN6;SOCS1;SOCS3;STAT1;STAT3;STAT5A |
| IkBA variant leads to EDA-ID | R-HSA-5603029 | http://reactome.org/PathwayBrowser/#/R-HSA-5603029 | 7 | 2 | 0.0636785748128494 | 31.407738095238 | 0.0016694955818834 | 0.0160818642209677 | 2 | IKBKB;NFKB1 |
| Inflammasomes | R-HSA-622312 | http://reactome.org/PathwayBrowser/#/R-HSA-622312 | 20 | 5 | 0.181938785179569 | 27.4817708333333 | 7.80562276592178E-7 | 3.24599678436503E-5 | 5 | BCL2;NFKB1;PYCARD;TXN;TXNIP |
| Interleukin-15 signaling | R-HSA-8983432 | http://reactome.org/PathwayBrowser/#/R-HSA-8983432 | 14 | 4 | 0.127357149625698 | 31.407738095238 | 6.00351657231712E-6 | 1.73491453488147E-4 | 4 | JAK1;JAK3;STAT3;STAT5A |
| Interleukin-2 signaling | R-HSA-9020558 | http://reactome.org/PathwayBrowser/#/R-HSA-9020558 | 12 | 3 | 0.109163271107741 | 27.4817708333333 | 1.51234949907319E-4 | 0.0023230233296574 | 3 | JAK1;JAK3;STAT5A |
| Interleukin-27 signaling | R-HSA-9020956 | http://reactome.org/PathwayBrowser/#/R-HSA-9020956 | 11 | 3 | 0.100066331848763 | 29.9801136363636 | 1.1417885191145E-4 | 0.0019085778677355 | 3 | JAK1;STAT1;STAT3 |
| Interleukin-6 signaling | R-HSA-1059683 | http://reactome.org/PathwayBrowser/#/R-HSA-1059683 | 11 | 4 | 0.100066331848763 | 39.9734848484848 | 2.02111861447029E-6 | 7.49132008189533E-5 | 4 | JAK1;SOCS3;STAT1;STAT3 |
| Interleukin-9 signaling | R-HSA-8985947 | http://reactome.org/PathwayBrowser/#/R-HSA-8985947 | 9 | 5 | 0.0818724533308064 | 61.0706018518518 | 6.86695167395612E-9 | 9.00627123391937E-7 | 5 | JAK1;JAK3;STAT1;STAT3;STAT5A |
| LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | R-HSA-3134973 | http://reactome.org/PathwayBrowser/#/R-HSA-3134973 | 5 | 3 | 0.0454846962948924 | 65.95625 | 7.2004191435937E-6 | 1.98011526448826E-4 | 3 | CTNNB1;EP300;IRF3 |
| MET activates PI3K/AKT signaling | R-HSA-8851907 | http://reactome.org/PathwayBrowser/#/R-HSA-8851907 | 6 | 2 | 0.0545816355538709 | 36.6423611111111 | 0.0011996024559172 | 0.012222247686099 | 2 | PIK3CA;PIK3R1 |
| NTRK2 activates RAC1 | R-HSA-9032759 | http://reactome.org/PathwayBrowser/#/R-HSA-9032759 | 5 | 2 | 0.0454846962948924 | 43.9708333333333 | 8.04503536981249E-4 | 0.0087928110932886 | 2 | FYN;RAC1 |
| PI3K/AKT activation | R-HSA-198203 | http://reactome.org/PathwayBrowser/#/R-HSA-198203 | 9 | 3 | 0.0818724533308064 | 36.6423611111111 | 5.89018228029925E-5 | 0.0010780218149171 | 3 | PIK3CA;PIK3R1;RHOA |
| PTK6 Expression | R-HSA-8849473 | http://reactome.org/PathwayBrowser/#/R-HSA-8849473 | 5 | 2 | 0.0454846962948924 | 43.9708333333333 | 8.04503536981249E-4 | 0.0087928110932886 | 2 | HIF1A;NR3C1 |
| RHO GTPases Activate NADPH Oxidases | R-HSA-5668599 | http://reactome.org/PathwayBrowser/#/R-HSA-5668599 | 13 | 4 | 0.11826021036672 | 33.8237179487179 | 4.31829613189993E-6 | 1.30570393728203E-4 | 4 | CYBA;NCF1;PIK3C3;RAC1 |
| RSK activation | R-HSA-444257 | http://reactome.org/PathwayBrowser/#/R-HSA-444257 | 6 | 2 | 0.0545816355538709 | 36.6423611111111 | 0.0011996024559172 | 0.012222247686099 | 2 | MAPK1;RPS6KA3 |
| RUNX2 regulates genes involved in cell migration | R-HSA-8941332 | http://reactome.org/PathwayBrowser/#/R-HSA-8941332 | 8 | 2 | 0.0727755140718279 | 27.4817708333333 | 0.0022128178631305 | 0.0199621928922623 | 2 | AKT1;RUNX2 |
| RUNX3 regulates CDKN1A transcription | R-HSA-8941855 | http://reactome.org/PathwayBrowser/#/R-HSA-8941855 | 7 | 2 | 0.0636785748128494 | 31.407738095238 | 0.0016694955818834 | 0.0160818642209677 | 2 | SMAD3;TGFB1 |
| Regulation of IFNG signaling | R-HSA-877312 | http://reactome.org/PathwayBrowser/#/R-HSA-877312 | 14 | 6 | 0.127357149625698 | 47.1116071428571 | 1.37041733516696E-9 | 2.12414686950879E-7 | 6 | IFNG;JAK1;PTPN6;SOCS1;SOCS3;STAT1 |
| Regulation of KIT signaling | R-HSA-1433559 | http://reactome.org/PathwayBrowser/#/R-HSA-1433559 | 16 | 4 | 0.145551028143655 | 27.4817708333333 | 1.07640459467983E-5 | 2.79871107778956E-4 | 4 | FYN;PRKCA;PTPN6;SOCS1 |
| SMAD2/3 Phosphorylation Motif Mutants in Cancer | R-HSA-3304356 | http://reactome.org/PathwayBrowser/#/R-HSA-3304356 | 6 | 4 | 0.0545816355538709 | 73.2847222222222 | 9.51391780912302E-8 | 7.05270863676294E-6 | 4 | SMAD2;SMAD3;TGFB1;TGFBR1 |
| Sema4D mediated inhibition of cell attachment and migration | R-HSA-416550 | http://reactome.org/PathwayBrowser/#/R-HSA-416550 | 8 | 2 | 0.0727755140718279 | 27.4817708333333 | 0.0022128178631305 | 0.0199621928922623 | 2 | RAC1;RHOA |
| Signaling by Leptin | R-HSA-2586552 | http://reactome.org/PathwayBrowser/#/R-HSA-2586552 | 11 | 3 | 0.100066331848763 | 29.9801136363636 | 1.1417885191145E-4 | 0.0019085778677355 | 3 | SOCS3;STAT3;STAT5A |
| Signaling by SCF-KIT | R-HSA-1433557 | http://reactome.org/PathwayBrowser/#/R-HSA-1433557 | 43 | 10 | 0.391168388136075 | 25.5644379844961 | 3.59867691201998E-12 | 8.76534876427724E-10 | 10 | FYN;PIK3CA;PIK3R1;PRKCA;PTPN6;RAC1;SOCS1;STAT1;STAT3;STAT5A |
| Signaling by cytosolic FGFR1 fusion mutants | R-HSA-1839117 | http://reactome.org/PathwayBrowser/#/R-HSA-1839117 | 18 | 5 | 0.163744906661612 | 30.5353009259259 | 4.37622386884051E-7 | 2.13277200140638E-5 | 5 | PIK3CA;PIK3R1;STAT1;STAT3;STAT5A |
| The NLRP3 inflammasome | R-HSA-844456 | http://reactome.org/PathwayBrowser/#/R-HSA-844456 | 15 | 4 | 0.136454088884677 | 29.3138888888888 | 8.12961936935696E-6 | 2.16578141011775E-4 | 4 | NFKB1;PYCARD;TXN;TXNIP |
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| Note: Edges are drawn between pathways based on their common genes, and the edge width is based on the number of those genes. | |||||||||
