Selected Cell
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PathwayEnrichmentResults_Top30
PathwayNetwork_Top30
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| id | geneSet | link | size | overlap | expect | enrichmentRatio | pValue | FDR | gene_count | genes |
| AKT phosphorylates targets in the cytosol | R-HSA-198323 | http://reactome.org/PathwayBrowser/#/R-HSA-198323 | 14 | 3 | 0.127357149625698 | 23.5558035714285 | 2.46938972258581E-4 | 0.0040483744971238 | 3 | AKT1;AKT1S1;CDKN1A |
| AKT phosphorylates targets in the nucleus | R-HSA-198693 | http://reactome.org/PathwayBrowser/#/R-HSA-198693 | 9 | 2 | 0.0818724533308064 | 24.4282407407407 | 0.0028282224460813 | 0.0263503785276981 | 2 | AKT1;FOXO1 |
| Activation of the AP-1 family of transcription factors | R-HSA-450341 | http://reactome.org/PathwayBrowser/#/R-HSA-450341 | 10 | 2 | 0.0909693925897849 | 21.9854166666666 | 0.003514380462803 | 0.0312084306722875 | 2 | JUN;MAPK8 |
| CD28 dependent PI3K/Akt signaling | R-HSA-389357 | http://reactome.org/PathwayBrowser/#/R-HSA-389357 | 22 | 5 | 0.200132663697526 | 24.983428030303 | 1.30685079058334E-6 | 8.91272239177842E-5 | 5 | AKT1;FYN;PDPK1;PIK3R1;TRIB3 |
| Constitutive Signaling by AKT1 E17K in Cancer | R-HSA-5674400 | http://reactome.org/PathwayBrowser/#/R-HSA-5674400 | 25 | 5 | 0.227423481474462 | 21.9854166666666 | 2.58029976973883E-6 | 1.51703831289817E-4 | 5 | AKT1;AKT1S1;CDKN1A;FOXO1;PDPK1 |
| Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | R-HSA-9027276 | http://reactome.org/PathwayBrowser/#/R-HSA-9027276 | 11 | 3 | 0.100066331848763 | 29.9801136363636 | 1.1417885191145E-4 | 0.0022122152557843 | 3 | IRS2;JAK2;PIK3R1 |
| Erythropoietin activates Phospholipase C gamma (PLCG) | R-HSA-9027277 | http://reactome.org/PathwayBrowser/#/R-HSA-9027277 | 6 | 2 | 0.0545816355538709 | 36.6423611111111 | 0.0011996024559172 | 0.0142036263009642 | 2 | IRS2;JAK2 |
| Erythropoietin activates STAT5 | R-HSA-9027283 | http://reactome.org/PathwayBrowser/#/R-HSA-9027283 | 6 | 3 | 0.0545816355538709 | 54.9635416666666 | 1.43056991090961E-5 | 5.18962063425723E-4 | 3 | IRS2;JAK2;STAT5A |
| Growth hormone receptor signaling | R-HSA-982772 | http://reactome.org/PathwayBrowser/#/R-HSA-982772 | 24 | 6 | 0.218326542215483 | 27.4817708333333 | 5.70790386067443E-8 | 9.73197608244991E-6 | 6 | IRS2;JAK2;PTPN6;STAT1;STAT3;STAT5A |
| IRS activation | R-HSA-74713 | http://reactome.org/PathwayBrowser/#/R-HSA-74713 | 5 | 2 | 0.0454846962948924 | 43.9708333333333 | 8.04503536981249E-4 | 0.0103133724101731 | 2 | INSR;IRS2 |
| InlA-mediated entry of Listeria monocytogenes into host cells | R-HSA-8876493 | http://reactome.org/PathwayBrowser/#/R-HSA-8876493 | 9 | 2 | 0.0818724533308064 | 24.4282407407407 | 0.0028282224460813 | 0.0263503785276981 | 2 | CTNNB1;UBC |
| Interleukin-15 signaling | R-HSA-8983432 | http://reactome.org/PathwayBrowser/#/R-HSA-8983432 | 14 | 3 | 0.127357149625698 | 23.5558035714285 | 2.46938972258581E-4 | 0.0040483744971238 | 3 | JAK1;STAT3;STAT5A |
| Interleukin-20 family signaling | R-HSA-8854691 | http://reactome.org/PathwayBrowser/#/R-HSA-8854691 | 25 | 5 | 0.227423481474462 | 21.9854166666666 | 2.58029976973883E-6 | 1.51703831289817E-4 | 5 | JAK1;JAK2;STAT1;STAT3;STAT5A |
| Interleukin-23 signaling | R-HSA-9020933 | http://reactome.org/PathwayBrowser/#/R-HSA-9020933 | 9 | 2 | 0.0818724533308064 | 24.4282407407407 | 0.0028282224460813 | 0.0263503785276981 | 2 | JAK2;STAT3 |
| Interleukin-27 signaling | R-HSA-9020956 | http://reactome.org/PathwayBrowser/#/R-HSA-9020956 | 11 | 4 | 0.100066331848763 | 39.9734848484848 | 2.02111861447029E-6 | 1.2762989769155E-4 | 4 | JAK1;JAK2;STAT1;STAT3 |
| Interleukin-9 signaling | R-HSA-8985947 | http://reactome.org/PathwayBrowser/#/R-HSA-8985947 | 9 | 4 | 0.0818724533308064 | 48.8564814814814 | 7.82568820301143E-7 | 6.3537135172069E-5 | 4 | JAK1;STAT1;STAT3;STAT5A |
| MAPK1 (ERK2) activation | R-HSA-112411 | http://reactome.org/PathwayBrowser/#/R-HSA-112411 | 9 | 2 | 0.0818724533308064 | 24.4282407407407 | 0.0028282224460813 | 0.0263503785276981 | 2 | JAK1;JAK2 |
| PI3K/AKT activation | R-HSA-198203 | http://reactome.org/PathwayBrowser/#/R-HSA-198203 | 9 | 3 | 0.0818724533308064 | 36.6423611111111 | 5.89018228029925E-5 | 0.0012827095012937 | 3 | IRS2;PIK3R1;RHOA |
| PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | R-HSA-8849469 | http://reactome.org/PathwayBrowser/#/R-HSA-8849469 | 9 | 2 | 0.0818724533308064 | 24.4282407407407 | 0.0028282224460813 | 0.0263503785276981 | 2 | AKT1;UBC |
| RUNX3 regulates CDKN1A transcription | R-HSA-8941855 | http://reactome.org/PathwayBrowser/#/R-HSA-8941855 | 7 | 3 | 0.0636785748128494 | 47.1116071428571 | 2.48696410016791E-5 | 6.95126850948571E-4 | 3 | CDKN1A;TGFB1;TP53 |
| RUNX3 regulates WNT signaling | R-HSA-8951430 | http://reactome.org/PathwayBrowser/#/R-HSA-8951430 | 8 | 2 | 0.0727755140718279 | 27.4817708333333 | 0.0022128178631305 | 0.0227280388954071 | 2 | CCND1;CTNNB1 |
| RUNX3 regulates p14-ARF | R-HSA-8951936 | http://reactome.org/PathwayBrowser/#/R-HSA-8951936 | 9 | 2 | 0.0818724533308064 | 24.4282407407407 | 0.0028282224460813 | 0.0263503785276981 | 2 | CCND1;TGFB1 |
| Regulation of IFNG signaling | R-HSA-877312 | http://reactome.org/PathwayBrowser/#/R-HSA-877312 | 14 | 4 | 0.127357149625698 | 31.407738095238 | 6.00351657231712E-6 | 2.92457021594305E-4 | 4 | JAK1;JAK2;PTPN6;STAT1 |
| Regulation of PTEN localization | R-HSA-8948747 | http://reactome.org/PathwayBrowser/#/R-HSA-8948747 | 9 | 2 | 0.0818724533308064 | 24.4282407407407 | 0.0028282224460813 | 0.0263503785276981 | 2 | PTEN;UBC |
| SMAD2/3 Phosphorylation Motif Mutants in Cancer | R-HSA-3304356 | http://reactome.org/PathwayBrowser/#/R-HSA-3304356 | 6 | 3 | 0.0545816355538709 | 54.9635416666666 | 1.43056991090961E-5 | 5.18962063425723E-4 | 3 | SMAD2;TGFB1;TGFBR1 |
| Signaling by Leptin | R-HSA-2586552 | http://reactome.org/PathwayBrowser/#/R-HSA-2586552 | 11 | 5 | 0.100066331848763 | 49.966856060606 | 2.48182896456228E-8 | 4.70168709397632E-6 | 5 | IRS2;JAK2;LEPR;STAT3;STAT5A |
| Signaling by cytosolic FGFR1 fusion mutants | R-HSA-1839117 | http://reactome.org/PathwayBrowser/#/R-HSA-1839117 | 18 | 4 | 0.163744906661612 | 24.4282407407407 | 1.78468175699997E-5 | 6.0857647913699E-4 | 4 | PIK3R1;STAT1;STAT3;STAT5A |
| TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | R-HSA-2173791 | http://reactome.org/PathwayBrowser/#/R-HSA-2173791 | 16 | 4 | 0.145551028143655 | 27.4817708333333 | 1.07640459467983E-5 | 4.2616736866341E-4 | 4 | RHOA;TGFB1;TGFBR1;UBC |
| Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | R-HSA-1474151 | http://reactome.org/PathwayBrowser/#/R-HSA-1474151 | 12 | 3 | 0.109163271107741 | 27.4817708333333 | 1.51234949907319E-4 | 0.0028027781477389 | 3 | AKT1;CALM1;HSP90AA1 |
| VEGFR2 mediated vascular permeability | R-HSA-5218920 | http://reactome.org/PathwayBrowser/#/R-HSA-5218920 | 29 | 6 | 0.263811238510376 | 22.7435344827586 | 1.9419536345655E-7 | 2.24051816582286E-5 | 6 | AKT1;CALM1;CTNNB1;HSP90AA1;PDPK1;TRIB3 |
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| Note: Edges are drawn between pathways based on their common genes, and the edge width is based on the number of those genes. | |||||||||
