Selected Cell
Cell:
Value:
PathwayEnrichmentResults_Top30
PathwayNetwork_Top30
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| id | geneSet | link | size | overlap | expect | enrichmentRatio | pValue | FDR | gene_count | genes |
| AKT phosphorylates targets in the cytosol | R-HSA-198323 | http://reactome.org/PathwayBrowser/#/R-HSA-198323 | 14 | 5 | 0.130010423576234 | 38.4584548104956 | 1.16763570590094E-7 | 1.11389608429638E-5 | 5 | AKT1;CASP9;CDKN1A;MDM2;TSC2 |
| Activated NTRK3 signals through PI3K | R-HSA-9603381 | http://reactome.org/PathwayBrowser/#/R-HSA-9603381 | 6 | 3 | 0.0557187529612432 | 53.8418367346938 | 1.52219083043858E-5 | 5.2966027875465E-4 | 3 | PIK3CA;PIK3R1;SRC |
| Activation of caspases through apoptosome-mediated cleavage | R-HSA-111459 | http://reactome.org/PathwayBrowser/#/R-HSA-111459 | 5 | 2 | 0.0464322941343693 | 43.0734693877551 | 8.38234495769585E-4 | 0.0091031198425932 | 2 | APAF1;CASP9 |
| Activation of the AP-1 family of transcription factors | R-HSA-450341 | http://reactome.org/PathwayBrowser/#/R-HSA-450341 | 10 | 3 | 0.0928645882687387 | 32.3051020408163 | 8.88932095696182E-5 | 0.0016474230686543 | 3 | FOS;JUN;MAPK1 |
| Constitutive Signaling by EGFRvIII | R-HSA-5637810 | http://reactome.org/PathwayBrowser/#/R-HSA-5637810 | 15 | 4 | 0.139296882403108 | 28.7156462585034 | 8.82529838164281E-6 | 3.41980312288658E-4 | 4 | EGFR;HSP90AA1;PIK3CA;PIK3R1 |
| Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | R-HSA-9027276 | http://reactome.org/PathwayBrowser/#/R-HSA-9027276 | 11 | 4 | 0.102151047095612 | 39.1576994434137 | 2.19540759660574E-6 | 1.29074825938372E-4 | 4 | IRS2;JAK2;PIK3CA;PIK3R1 |
| Erythropoietin activates Phospholipase C gamma (PLCG) | R-HSA-9027277 | http://reactome.org/PathwayBrowser/#/R-HSA-9027277 | 6 | 2 | 0.0557187529612432 | 35.8945578231292 | 0.0012497407895022 | 0.012388418872682 | 2 | IRS2;JAK2 |
| GAB1 signalosome | R-HSA-180292 | http://reactome.org/PathwayBrowser/#/R-HSA-180292 | 11 | 4 | 0.102151047095612 | 39.1576994434137 | 2.19540759660574E-6 | 1.29074825938372E-4 | 4 | EGFR;PIK3CA;PIK3R1;SRC |
| Growth hormone receptor signaling | R-HSA-982772 | http://reactome.org/PathwayBrowser/#/R-HSA-982772 | 24 | 7 | 0.222875011844973 | 31.407738095238 | 1.45845324706073E-9 | 2.40871073087234E-7 | 7 | IRS2;JAK2;MAPK1;PTPN6;SOCS1;SOCS3;STAT1 |
| IRS activation | R-HSA-74713 | http://reactome.org/PathwayBrowser/#/R-HSA-74713 | 5 | 2 | 0.0464322941343693 | 43.0734693877551 | 8.38234495769585E-4 | 0.0091031198425932 | 2 | INSR;IRS2 |
| IkBA variant leads to EDA-ID | R-HSA-5603029 | http://reactome.org/PathwayBrowser/#/R-HSA-5603029 | 7 | 2 | 0.0650052117881171 | 30.7667638483965 | 0.0017390536491741 | 0.0155240129415807 | 2 | IKBKB;NFKB2 |
| InlA-mediated entry of Listeria monocytogenes into host cells | R-HSA-8876493 | http://reactome.org/PathwayBrowser/#/R-HSA-8876493 | 9 | 3 | 0.0835781294418648 | 35.8945578231292 | 6.26473751649259E-5 | 0.0012566326430141 | 3 | CDH1;CTNNB1;SRC |
| Interleukin-27 signaling | R-HSA-9020956 | http://reactome.org/PathwayBrowser/#/R-HSA-9020956 | 11 | 3 | 0.102151047095612 | 29.3682745825603 | 1.21404885309539E-4 | 0.0022020779729017 | 3 | JAK1;JAK2;STAT1 |
| Interleukin-6 signaling | R-HSA-1059683 | http://reactome.org/PathwayBrowser/#/R-HSA-1059683 | 11 | 4 | 0.102151047095612 | 39.1576994434137 | 2.19540759660574E-6 | 1.29074825938372E-4 | 4 | JAK1;JAK2;SOCS3;STAT1 |
| LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | R-HSA-3134973 | http://reactome.org/PathwayBrowser/#/R-HSA-3134973 | 5 | 2 | 0.0464322941343693 | 43.0734693877551 | 8.38234495769585E-4 | 0.0091031198425932 | 2 | CTNNB1;EP300 |
| Loss of Function of SMAD2/3 in Cancer | R-HSA-3304349 | http://reactome.org/PathwayBrowser/#/R-HSA-3304349 | 7 | 4 | 0.0650052117881171 | 61.533527696793 | 2.39598946905061E-7 | 1.94531525939585E-5 | 4 | SMAD2;SMAD3;SMAD4;TGFB1 |
| MAPK1 (ERK2) activation | R-HSA-112411 | http://reactome.org/PathwayBrowser/#/R-HSA-112411 | 9 | 3 | 0.0835781294418648 | 35.8945578231292 | 6.26473751649259E-5 | 0.0012566326430141 | 3 | JAK1;JAK2;MAPK1 |
| MET activates PI3K/AKT signaling | R-HSA-8851907 | http://reactome.org/PathwayBrowser/#/R-HSA-8851907 | 6 | 2 | 0.0557187529612432 | 35.8945578231292 | 0.0012497407895022 | 0.012388418872682 | 2 | PIK3CA;PIK3R1 |
| PI3K/AKT activation | R-HSA-198203 | http://reactome.org/PathwayBrowser/#/R-HSA-198203 | 9 | 3 | 0.0835781294418648 | 35.8945578231292 | 6.26473751649259E-5 | 0.0012566326430141 | 3 | IRS2;PIK3CA;PIK3R1 |
| PTK6 Expression | R-HSA-8849473 | http://reactome.org/PathwayBrowser/#/R-HSA-8849473 | 5 | 2 | 0.0464322941343693 | 43.0734693877551 | 8.38234495769585E-4 | 0.0091031198425932 | 2 | HIF1A;NR3C1 |
| PTK6 promotes HIF1A stabilization | R-HSA-8857538 | http://reactome.org/PathwayBrowser/#/R-HSA-8857538 | 6 | 2 | 0.0557187529612432 | 35.8945578231292 | 0.0012497407895022 | 0.012388418872682 | 2 | EGFR;HIF1A |
| RSK activation | R-HSA-444257 | http://reactome.org/PathwayBrowser/#/R-HSA-444257 | 6 | 2 | 0.0557187529612432 | 35.8945578231292 | 0.0012497407895022 | 0.012388418872682 | 2 | MAPK1;RPS6KA3 |
| RUNX3 regulates BCL2L11 (BIM) transcription | R-HSA-8952158 | http://reactome.org/PathwayBrowser/#/R-HSA-8952158 | 5 | 2 | 0.0464322941343693 | 43.0734693877551 | 8.38234495769585E-4 | 0.0091031198425932 | 2 | SMAD3;SMAD4 |
| RUNX3 regulates CDKN1A transcription | R-HSA-8941855 | http://reactome.org/PathwayBrowser/#/R-HSA-8941855 | 7 | 5 | 0.0650052117881171 | 76.9169096209912 | 1.28963473233767E-9 | 2.40871073087234E-7 | 5 | CDKN1A;SMAD3;SMAD4;TGFB1;TP53 |
| RUNX3 regulates p14-ARF | R-HSA-8951936 | http://reactome.org/PathwayBrowser/#/R-HSA-8951936 | 9 | 3 | 0.0835781294418648 | 35.8945578231292 | 6.26473751649259E-5 | 0.0012566326430141 | 3 | EP300;HDAC4;TGFB1 |
| Regulation of IFNG signaling | R-HSA-877312 | http://reactome.org/PathwayBrowser/#/R-HSA-877312 | 14 | 6 | 0.130010423576234 | 46.1501457725947 | 1.55400692314344E-9 | 2.40871073087234E-7 | 6 | JAK1;JAK2;PTPN6;SOCS1;SOCS3;STAT1 |
| SMAD2/3 Phosphorylation Motif Mutants in Cancer | R-HSA-3304356 | http://reactome.org/PathwayBrowser/#/R-HSA-3304356 | 6 | 3 | 0.0557187529612432 | 53.8418367346938 | 1.52219083043858E-5 | 5.2966027875465E-4 | 3 | SMAD2;SMAD3;TGFB1 |
| Signal attenuation | R-HSA-74749 | http://reactome.org/PathwayBrowser/#/R-HSA-74749 | 10 | 3 | 0.0928645882687387 | 32.3051020408163 | 8.88932095696182E-5 | 0.0016474230686543 | 3 | INSR;IRS2;MAPK1 |
| Signaling by Leptin | R-HSA-2586552 | http://reactome.org/PathwayBrowser/#/R-HSA-2586552 | 11 | 4 | 0.102151047095612 | 39.1576994434137 | 2.19540759660574E-6 | 1.29074825938372E-4 | 4 | IRS2;JAK2;LEPR;SOCS3 |
| VLDLR internalisation and degradation | R-HSA-8866427 | http://reactome.org/PathwayBrowser/#/R-HSA-8866427 | 12 | 3 | 0.111437505922486 | 26.9209183673469 | 1.60783289586574E-4 | 0.0025861840447651 | 3 | CLTC;MYLIP;VLDLR |
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| Note: Edges are drawn between pathways based on their common genes, and the edge width is based on the number of those genes. | |||||||||
