Selected Cell
Cell:
Value:
PathwayEnrichmentResults_Top30
PathwayNetwork_Top30
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| id | geneSet | link | size | overlap | expect | enrichmentRatio | pValue | FDR | gene_count | genes |
| AKT phosphorylates targets in the cytosol | R-HSA-198323 | http://reactome.org/PathwayBrowser/#/R-HSA-198323 | 14 | 4 | 0.132663697526769 | 30.1514285714285 | 7.06495424362962E-6 | 2.56292489050819E-4 | 4 | AKT1;BAD;MDM2;TSC2 |
| Activation of the AP-1 family of transcription factors | R-HSA-450341 | http://reactome.org/PathwayBrowser/#/R-HSA-450341 | 10 | 3 | 0.0947597839476926 | 31.659 | 9.44118958285944E-5 | 0.0018937915575029 | 3 | FOS;JUN;MAPK1 |
| BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | R-HSA-111453 | http://reactome.org/PathwayBrowser/#/R-HSA-111453 | 9 | 2 | 0.0852838055529233 | 23.4511111111111 | 0.0030646740603866 | 0.0248822346331395 | 2 | BAD;STAT3 |
| Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | R-HSA-9027276 | http://reactome.org/PathwayBrowser/#/R-HSA-9027276 | 11 | 3 | 0.104235762342461 | 28.780909090909 | 1.28923620684728E-4 | 0.0024423863696384 | 3 | JAK2;PIK3CA;PIK3R1 |
| Interleukin-23 signaling | R-HSA-9020933 | http://reactome.org/PathwayBrowser/#/R-HSA-9020933 | 9 | 2 | 0.0852838055529233 | 23.4511111111111 | 0.0030646740603866 | 0.0248822346331395 | 2 | JAK2;STAT3 |
| Interleukin-27 signaling | R-HSA-9020956 | http://reactome.org/PathwayBrowser/#/R-HSA-9020956 | 11 | 4 | 0.104235762342461 | 38.3745454545454 | 2.38062954549533E-6 | 1.3562899506601E-4 | 4 | JAK1;JAK2;STAT1;STAT3 |
| Interleukin-6 signaling | R-HSA-1059683 | http://reactome.org/PathwayBrowser/#/R-HSA-1059683 | 11 | 5 | 0.104235762342461 | 47.9681818181818 | 3.05108128761943E-8 | 3.46806239692742E-6 | 5 | JAK1;JAK2;SOCS3;STAT1;STAT3 |
| Interleukin-9 signaling | R-HSA-8985947 | http://reactome.org/PathwayBrowser/#/R-HSA-8985947 | 9 | 3 | 0.0852838055529233 | 35.1766666666666 | 6.65461393546396E-5 | 0.0014735216571384 | 3 | JAK1;STAT1;STAT3 |
| LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | R-HSA-3134973 | http://reactome.org/PathwayBrowser/#/R-HSA-3134973 | 5 | 2 | 0.0473798919738463 | 42.212 | 8.72644786142906E-4 | 0.009919062402491 | 2 | CTNNB1;EP300 |
| Loss of Function of SMAD2/3 in Cancer | R-HSA-3304349 | http://reactome.org/PathwayBrowser/#/R-HSA-3304349 | 7 | 3 | 0.0663318487633848 | 45.2271428571428 | 2.8113270860941E-5 | 7.60843282823881E-4 | 3 | SMAD2;SMAD4;TGFB1 |
| MAPK1 (ERK2) activation | R-HSA-112411 | http://reactome.org/PathwayBrowser/#/R-HSA-112411 | 9 | 3 | 0.0852838055529233 | 35.1766666666666 | 6.65461393546396E-5 | 0.0014735216571384 | 3 | JAK1;JAK2;MAPK1 |
| MET activates PI3K/AKT signaling | R-HSA-8851907 | http://reactome.org/PathwayBrowser/#/R-HSA-8851907 | 6 | 2 | 0.0568558703686155 | 35.1766666666666 | 0.0013008791078581 | 0.0138624929931133 | 2 | PIK3CA;PIK3R1 |
| NTRK2 activates RAC1 | R-HSA-9032759 | http://reactome.org/PathwayBrowser/#/R-HSA-9032759 | 5 | 2 | 0.0473798919738463 | 42.212 | 8.72644786142906E-4 | 0.009919062402491 | 2 | FYN;RAC1 |
| PI3K/AKT activation | R-HSA-198203 | http://reactome.org/PathwayBrowser/#/R-HSA-198203 | 9 | 3 | 0.0852838055529233 | 35.1766666666666 | 6.65461393546396E-5 | 0.0014735216571384 | 3 | PIK3CA;PIK3R1;RHOA |
| PTK6 Expression | R-HSA-8849473 | http://reactome.org/PathwayBrowser/#/R-HSA-8849473 | 5 | 2 | 0.0473798919738463 | 42.212 | 8.72644786142906E-4 | 0.009919062402491 | 2 | HIF1A;NR3C1 |
| PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | R-HSA-8849469 | http://reactome.org/PathwayBrowser/#/R-HSA-8849469 | 9 | 2 | 0.0852838055529233 | 23.4511111111111 | 0.0030646740603866 | 0.0248822346331395 | 2 | AKT1;UBC |
| RUNX3 regulates CDKN1A transcription | R-HSA-8941855 | http://reactome.org/PathwayBrowser/#/R-HSA-8941855 | 7 | 2 | 0.0663318487633848 | 30.1514285714285 | 0.001809985442657 | 0.0175342339757405 | 2 | SMAD4;TGFB1 |
| RUNX3 regulates WNT signaling | R-HSA-8951430 | http://reactome.org/PathwayBrowser/#/R-HSA-8951430 | 8 | 2 | 0.075807827158154 | 26.3825 | 0.0023984234112683 | 0.0214100100325267 | 2 | CCND1;CTNNB1 |
| RUNX3 regulates p14-ARF | R-HSA-8951936 | http://reactome.org/PathwayBrowser/#/R-HSA-8951936 | 9 | 3 | 0.0852838055529233 | 35.1766666666666 | 6.65461393546396E-5 | 0.0014735216571384 | 3 | CCND1;EP300;TGFB1 |
| Reelin signalling pathway | R-HSA-8866376 | http://reactome.org/PathwayBrowser/#/R-HSA-8866376 | 5 | 2 | 0.0473798919738463 | 42.212 | 8.72644786142906E-4 | 0.009919062402491 | 2 | FYN;VLDLR |
| Regulation of IFNG signaling | R-HSA-877312 | http://reactome.org/PathwayBrowser/#/R-HSA-877312 | 14 | 4 | 0.132663697526769 | 30.1514285714285 | 7.06495424362962E-6 | 2.56292489050819E-4 | 4 | JAK1;JAK2;SOCS3;STAT1 |
| Regulation of PTEN localization | R-HSA-8948747 | http://reactome.org/PathwayBrowser/#/R-HSA-8948747 | 9 | 2 | 0.0852838055529233 | 23.4511111111111 | 0.0030646740603866 | 0.0248822346331395 | 2 | PTEN;UBC |
| Regulation of gene expression by Hypoxia-inducible Factor | R-HSA-1234158 | http://reactome.org/PathwayBrowser/#/R-HSA-1234158 | 11 | 3 | 0.104235762342461 | 28.780909090909 | 1.28923620684728E-4 | 0.0024423863696384 | 3 | EP300;HIF1A;VEGFA |
| SHC-related events triggered by IGF1R | R-HSA-2428933 | http://reactome.org/PathwayBrowser/#/R-HSA-2428933 | 9 | 2 | 0.0852838055529233 | 23.4511111111111 | 0.0030646740603866 | 0.0248822346331395 | 2 | IGF1;IGF1R |
| SMAD2/3 Phosphorylation Motif Mutants in Cancer | R-HSA-3304356 | http://reactome.org/PathwayBrowser/#/R-HSA-3304356 | 6 | 2 | 0.0568558703686155 | 35.1766666666666 | 0.0013008791078581 | 0.0138624929931133 | 2 | SMAD2;TGFB1 |
| Sema4D mediated inhibition of cell attachment and migration | R-HSA-416550 | http://reactome.org/PathwayBrowser/#/R-HSA-416550 | 8 | 2 | 0.075807827158154 | 26.3825 | 0.0023984234112683 | 0.0214100100325267 | 2 | RAC1;RHOA |
| Signaling by Leptin | R-HSA-2586552 | http://reactome.org/PathwayBrowser/#/R-HSA-2586552 | 11 | 4 | 0.104235762342461 | 38.3745454545454 | 2.38062954549533E-6 | 1.3562899506601E-4 | 4 | JAK2;LEPR;SOCS3;STAT3 |
| Signaling by cytosolic FGFR1 fusion mutants | R-HSA-1839117 | http://reactome.org/PathwayBrowser/#/R-HSA-1839117 | 18 | 4 | 0.170567611105846 | 23.4511111111111 | 2.09766881028583E-5 | 6.2746058272585E-4 | 4 | PIK3CA;PIK3R1;STAT1;STAT3 |
| Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | R-HSA-1474151 | http://reactome.org/PathwayBrowser/#/R-HSA-1474151 | 12 | 3 | 0.113711740737231 | 26.3825 | 1.70716498141487E-4 | 0.0029952732014232 | 3 | AKT1;CALM1;HSP90AA1 |
| VEGF ligand-receptor interactions | R-HSA-194313 | http://reactome.org/PathwayBrowser/#/R-HSA-194313 | 8 | 2 | 0.075807827158154 | 26.3825 | 0.0023984234112683 | 0.0214100100325267 | 2 | KDR;VEGFA |
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| Note: Edges are drawn between pathways based on their common genes, and the edge width is based on the number of those genes. | |||||||||
