Selected Cell
Cell:
Value:
PathwayEnrichmentResults_Top30
PathwayNetwork_Top30
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| id | geneSet | link | size | overlap | expect | enrichmentRatio | pValue | FDR | gene_count | genes |
| AKT phosphorylates targets in the cytosol | R-HSA-198323 | http://reactome.org/PathwayBrowser/#/R-HSA-198323 | 14 | 4 | 0.147256704254714 | 27.1634491634491 | 1.07004181814085E-5 | 4.63574780766809E-4 | 4 | AKT1;BAD;MDM2;TSC2 |
| Activation of BAD and translocation to mitochondria | R-HSA-111447 | http://reactome.org/PathwayBrowser/#/R-HSA-111447 | 15 | 4 | 0.157775040272908 | 25.3525525525525 | 1.44733906974892E-5 | 5.2504534338764E-4 | 4 | AKT1;BAD;BCL2;YWHAZ |
| Activation of the AP-1 family of transcription factors | R-HSA-450341 | http://reactome.org/PathwayBrowser/#/R-HSA-450341 | 10 | 3 | 0.105183360181938 | 28.5216216216216 | 1.28801058103644E-4 | 0.0020914838482544 | 3 | FOS;JUN;MAPK1 |
| BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | R-HSA-111453 | http://reactome.org/PathwayBrowser/#/R-HSA-111453 | 9 | 3 | 0.0946650241637449 | 31.6906906906906 | 9.0856458118016E-5 | 0.0016838071857741 | 3 | BAD;BCL2;STAT3 |
| CLEC7A/inflammasome pathway | R-HSA-5660668 | http://reactome.org/PathwayBrowser/#/R-HSA-5660668 | 6 | 2 | 0.0631100161091632 | 31.6906906906906 | 0.0015999446281327 | 0.0154994635850358 | 2 | NFKB1;RELA |
| Inflammasomes | R-HSA-622312 | http://reactome.org/PathwayBrowser/#/R-HSA-622312 | 20 | 5 | 0.210366720363877 | 23.768018018018 | 1.60769521784231E-6 | 1.14213347767548E-4 | 5 | BCL2;NFKB1;RELA;TXN;TXNIP |
| InlA-mediated entry of Listeria monocytogenes into host cells | R-HSA-8876493 | http://reactome.org/PathwayBrowser/#/R-HSA-8876493 | 9 | 3 | 0.0946650241637449 | 31.6906906906906 | 9.0856458118016E-5 | 0.0016838071857741 | 3 | CDH1;CTNNB1;UBC |
| Interleukin-6 signaling | R-HSA-1059683 | http://reactome.org/PathwayBrowser/#/R-HSA-1059683 | 11 | 4 | 0.115701696200132 | 34.5716625716625 | 3.61470986309786E-6 | 2.28262233947476E-4 | 4 | JAK1;SOCS3;STAT1;STAT3 |
| Interleukin-9 signaling | R-HSA-8985947 | http://reactome.org/PathwayBrowser/#/R-HSA-8985947 | 9 | 3 | 0.0946650241637449 | 31.6906906906906 | 9.0856458118016E-5 | 0.0016838071857741 | 3 | JAK1;STAT1;STAT3 |
| LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | R-HSA-3134973 | http://reactome.org/PathwayBrowser/#/R-HSA-3134973 | 5 | 3 | 0.0525916800909693 | 57.0432432432432 | 1.11543630972876E-5 | 4.63574780766809E-4 | 3 | CTNNB1;EP300;IRF3 |
| Loss of Function of SMAD2/3 in Cancer | R-HSA-3304349 | http://reactome.org/PathwayBrowser/#/R-HSA-3304349 | 7 | 4 | 0.0736283521273571 | 54.3268983268983 | 3.96063262853019E-7 | 3.55414664823367E-5 | 4 | SMAD2;SMAD3;SMAD4;TGFBR1 |
| MAPK1 (ERK2) activation | R-HSA-112411 | http://reactome.org/PathwayBrowser/#/R-HSA-112411 | 9 | 2 | 0.0946650241637449 | 21.1271271271271 | 0.0037613873044337 | 0.0296905803428683 | 2 | JAK1;MAPK1 |
| NF-kB is activated and signals survival | R-HSA-209560 | http://reactome.org/PathwayBrowser/#/R-HSA-209560 | 13 | 3 | 0.13673836823652 | 21.9397089397089 | 2.99984102588801E-4 | 0.0040593086897929 | 3 | NFKB1;RELA;UBC |
| PI3K/AKT activation | R-HSA-198203 | http://reactome.org/PathwayBrowser/#/R-HSA-198203 | 9 | 2 | 0.0946650241637449 | 21.1271271271271 | 0.0037613873044337 | 0.0296905803428683 | 2 | PIK3R1;RHOA |
| PTK6 Expression | R-HSA-8849473 | http://reactome.org/PathwayBrowser/#/R-HSA-8849473 | 5 | 2 | 0.0525916800909693 | 38.0288288288288 | 0.0010740089510531 | 0.0118140984615845 | 2 | HIF1A;NR3C1 |
| PTK6 promotes HIF1A stabilization | R-HSA-8857538 | http://reactome.org/PathwayBrowser/#/R-HSA-8857538 | 6 | 2 | 0.0631100161091632 | 31.6906906906906 | 0.0015999446281327 | 0.0154994635850358 | 2 | EGFR;HIF1A |
| RHO GTPases activate KTN1 | R-HSA-5625970 | http://reactome.org/PathwayBrowser/#/R-HSA-5625970 | 11 | 3 | 0.115701696200132 | 25.9287469287469 | 1.75745938693849E-4 | 0.0026517418183452 | 3 | KTN1;RAC1;RHOA |
| RSK activation | R-HSA-444257 | http://reactome.org/PathwayBrowser/#/R-HSA-444257 | 6 | 2 | 0.0631100161091632 | 31.6906906906906 | 0.0015999446281327 | 0.0154994635850358 | 2 | MAPK1;RPS6KA3 |
| RUNX3 regulates BCL2L11 (BIM) transcription | R-HSA-8952158 | http://reactome.org/PathwayBrowser/#/R-HSA-8952158 | 5 | 2 | 0.0525916800909693 | 38.0288288288288 | 0.0010740089510531 | 0.0118140984615845 | 2 | SMAD3;SMAD4 |
| RUNX3 regulates CDKN1A transcription | R-HSA-8941855 | http://reactome.org/PathwayBrowser/#/R-HSA-8941855 | 7 | 3 | 0.0736283521273571 | 40.7451737451737 | 3.8443747117256E-5 | 9.55390406001591E-4 | 3 | SMAD3;SMAD4;TP53 |
| RUNX3 regulates WNT signaling | R-HSA-8951430 | http://reactome.org/PathwayBrowser/#/R-HSA-8951430 | 8 | 2 | 0.084146688145551 | 23.768018018018 | 0.0029457137830303 | 0.0252384020103854 | 2 | CCND1;CTNNB1 |
| Regulation of PTEN localization | R-HSA-8948747 | http://reactome.org/PathwayBrowser/#/R-HSA-8948747 | 9 | 2 | 0.0946650241637449 | 21.1271271271271 | 0.0037613873044337 | 0.0296905803428683 | 2 | PTEN;UBC |
| Regulation of gene expression by Hypoxia-inducible Factor | R-HSA-1234158 | http://reactome.org/PathwayBrowser/#/R-HSA-1234158 | 11 | 3 | 0.115701696200132 | 25.9287469287469 | 1.75745938693849E-4 | 0.0026517418183452 | 3 | EP300;HIF1A;VEGFA |
| SHC-related events triggered by IGF1R | R-HSA-2428933 | http://reactome.org/PathwayBrowser/#/R-HSA-2428933 | 9 | 2 | 0.0946650241637449 | 21.1271271271271 | 0.0037613873044337 | 0.0296905803428683 | 2 | IGF1;IGF1R |
| SMAD2/3 Phosphorylation Motif Mutants in Cancer | R-HSA-3304356 | http://reactome.org/PathwayBrowser/#/R-HSA-3304356 | 6 | 3 | 0.0631100161091632 | 47.536036036036 | 2.21375968939563E-5 | 6.98716560258105E-4 | 3 | SMAD2;SMAD3;TGFBR1 |
| Sema4D mediated inhibition of cell attachment and migration | R-HSA-416550 | http://reactome.org/PathwayBrowser/#/R-HSA-416550 | 8 | 2 | 0.084146688145551 | 23.768018018018 | 0.0029457137830303 | 0.0252384020103854 | 2 | RAC1;RHOA |
| Signaling by Activin | R-HSA-1502540 | http://reactome.org/PathwayBrowser/#/R-HSA-1502540 | 13 | 3 | 0.13673836823652 | 21.9397089397089 | 2.99984102588801E-4 | 0.0040593086897929 | 3 | SMAD2;SMAD3;SMAD4 |
| TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | R-HSA-6804114 | http://reactome.org/PathwayBrowser/#/R-HSA-6804114 | 18 | 4 | 0.189330048327489 | 21.1271271271271 | 3.1664868980874E-5 | 9.15061044277801E-4 | 4 | BAX;EP300;PCNA;TP53 |
| Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | R-HSA-1474151 | http://reactome.org/PathwayBrowser/#/R-HSA-1474151 | 12 | 3 | 0.126220032218326 | 23.768018018018 | 2.32535202009498E-4 | 0.003276632391952 | 3 | AKT1;CALM1;HSP90AA1 |
| The NLRP3 inflammasome | R-HSA-844456 | http://reactome.org/PathwayBrowser/#/R-HSA-844456 | 15 | 4 | 0.157775040272908 | 25.3525525525525 | 1.44733906974892E-5 | 5.2504534338764E-4 | 4 | NFKB1;RELA;TXN;TXNIP |
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| Note: Edges are drawn between pathways based on their common genes, and the edge width is based on the number of those genes. | |||||||||
