Selected Cell
Cell:
Value:
PathwayEnrichmentResults_Top30
PathwayNetwork_Top30
A
B
C
D
E
F
G
H
I
J
K
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
| id | geneSet | link | size | overlap | expect | enrichmentRatio | pValue | FDR | gene_count | genes |
| AKT phosphorylates targets in the cytosol | R-HSA-198323 | http://reactome.org/PathwayBrowser/#/R-HSA-198323 | 14 | 4 | 0.152563252155785 | 26.2186335403726 | 1.23142889755234E-5 | 2.65816833821978E-4 | 4 | AKT1;BAD;CDKN1A;MDM2 |
| Activation of BAD and translocation to mitochondria | R-HSA-111447 | http://reactome.org/PathwayBrowser/#/R-HSA-111447 | 15 | 4 | 0.163460627309769 | 24.4707246376811 | 1.66512512559391E-5 | 3.34004510486779E-4 | 4 | AKT1;BAD;YWHAB;YWHAZ |
| Activation of the AP-1 family of transcription factors | R-HSA-450341 | http://reactome.org/PathwayBrowser/#/R-HSA-450341 | 10 | 3 | 0.108973751539846 | 27.5295652173913 | 1.43083548345801E-4 | 0.0017807113133546 | 3 | FOS;JUN;MAPK1 |
| CLEC7A/inflammasome pathway | R-HSA-5660668 | http://reactome.org/PathwayBrowser/#/R-HSA-5660668 | 6 | 3 | 0.0653842509239079 | 45.8826086956521 | 2.46204738763022E-5 | 4.35511988925137E-4 | 3 | NFKB1;PYCARD;RELA |
| Cross-presentation of particulate exogenous antigens (phagosomes) | R-HSA-1236973 | http://reactome.org/PathwayBrowser/#/R-HSA-1236973 | 8 | 3 | 0.0871790012318771 | 34.4119565217391 | 6.78456841473051E-5 | 9.78077194518821E-4 | 3 | CYBA;CYBB;NCF1 |
| DEx/H-box helicases activate type I IFN and inflammatory cytokines production | R-HSA-3134963 | http://reactome.org/PathwayBrowser/#/R-HSA-3134963 | 7 | 2 | 0.0762816260778925 | 26.2186335403726 | 0.0023854889847254 | 0.0190951113566052 | 2 | NFKB1;RELA |
| Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | R-HSA-9027276 | http://reactome.org/PathwayBrowser/#/R-HSA-9027276 | 11 | 3 | 0.119871126693831 | 25.0268774703557 | 1.95178494644121E-4 | 0.0023271282053722 | 3 | IRS2;JAK2;PIK3CA |
| Erythropoietin activates Phospholipase C gamma (PLCG) | R-HSA-9027277 | http://reactome.org/PathwayBrowser/#/R-HSA-9027277 | 6 | 2 | 0.0653842509239079 | 30.5884057971014 | 0.0017161330605863 | 0.0142732042356086 | 2 | IRS2;JAK2 |
| Erythropoietin activates STAT5 | R-HSA-9027283 | http://reactome.org/PathwayBrowser/#/R-HSA-9027283 | 6 | 3 | 0.0653842509239079 | 45.8826086956521 | 2.46204738763022E-5 | 4.35511988925137E-4 | 3 | IRS2;JAK2;STAT5A |
| Growth hormone receptor signaling | R-HSA-982772 | http://reactome.org/PathwayBrowser/#/R-HSA-982772 | 24 | 9 | 0.261537003695631 | 34.4119565217391 | 1.79967152291737E-12 | 3.83554993321766E-10 | 9 | IRS2;JAK2;MAPK1;PTPN6;SOCS1;SOCS3;STAT1;STAT3;STAT5A |
| IRS activation | R-HSA-74713 | http://reactome.org/PathwayBrowser/#/R-HSA-74713 | 5 | 2 | 0.0544868757699232 | 36.7060869565217 | 0.001152295531683 | 0.0101271334098949 | 2 | INSR;IRS2 |
| IkBA variant leads to EDA-ID | R-HSA-5603029 | http://reactome.org/PathwayBrowser/#/R-HSA-5603029 | 7 | 3 | 0.0762816260778925 | 39.327950310559 | 4.27432502390079E-5 | 6.5655172664422E-4 | 3 | IKBKB;NFKB1;RELA |
| Interleukin-27 signaling | R-HSA-9020956 | http://reactome.org/PathwayBrowser/#/R-HSA-9020956 | 11 | 4 | 0.119871126693831 | 33.3691699604743 | 4.16369155065154E-6 | 1.14501517642917E-4 | 4 | JAK1;JAK2;STAT1;STAT3 |
| Interleukin-6 signaling | R-HSA-1059683 | http://reactome.org/PathwayBrowser/#/R-HSA-1059683 | 11 | 5 | 0.119871126693831 | 41.7114624505928 | 6.17534916536044E-8 | 3.50965677564651E-6 | 5 | JAK1;JAK2;SOCS3;STAT1;STAT3 |
| Interleukin-9 signaling | R-HSA-8985947 | http://reactome.org/PathwayBrowser/#/R-HSA-8985947 | 9 | 4 | 0.0980763763858618 | 40.7845410628019 | 1.61683813115764E-6 | 5.20133776155432E-5 | 4 | JAK1;STAT1;STAT3;STAT5A |
| LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | R-HSA-3134973 | http://reactome.org/PathwayBrowser/#/R-HSA-3134973 | 5 | 3 | 0.0544868757699232 | 55.0591304347826 | 1.24089471361665E-5 | 2.65816833821978E-4 | 3 | CTNNB1;EP300;IRF3 |
| Loss of Function of SMAD2/3 in Cancer | R-HSA-3304349 | http://reactome.org/PathwayBrowser/#/R-HSA-3304349 | 7 | 4 | 0.0762816260778925 | 52.4372670807453 | 4.5677205917638E-7 | 1.76999172930847E-5 | 4 | SMAD2;SMAD4;TGFB1;TGFBR1 |
| MAPK1 (ERK2) activation | R-HSA-112411 | http://reactome.org/PathwayBrowser/#/R-HSA-112411 | 9 | 3 | 0.0980763763858618 | 30.5884057971014 | 1.00960107155323E-4 | 0.0013244429451766 | 3 | JAK1;JAK2;MAPK1 |
| NF-kB is activated and signals survival | R-HSA-209560 | http://reactome.org/PathwayBrowser/#/R-HSA-209560 | 13 | 4 | 0.1416658770018 | 28.2354515050167 | 8.87040369268454E-6 | 2.10056087444821E-4 | 4 | IKBKB;IRAK1;NFKB1;RELA |
| NTRK2 activates RAC1 | R-HSA-9032759 | http://reactome.org/PathwayBrowser/#/R-HSA-9032759 | 5 | 2 | 0.0544868757699232 | 36.7060869565217 | 0.001152295531683 | 0.0101271334098949 | 2 | FYN;RAC1 |
| PTK6 Expression | R-HSA-8849473 | http://reactome.org/PathwayBrowser/#/R-HSA-8849473 | 5 | 2 | 0.0544868757699232 | 36.7060869565217 | 0.001152295531683 | 0.0101271334098949 | 2 | HIF1A;NR3C1 |
| RHO GTPases Activate NADPH Oxidases | R-HSA-5668599 | http://reactome.org/PathwayBrowser/#/R-HSA-5668599 | 13 | 5 | 0.1416658770018 | 35.2943143812709 | 1.69053879561786E-7 | 7.58518064875912E-6 | 5 | CYBA;CYBB;NCF1;PIK3C3;RAC1 |
| RSK activation | R-HSA-444257 | http://reactome.org/PathwayBrowser/#/R-HSA-444257 | 6 | 3 | 0.0653842509239079 | 45.8826086956521 | 2.46204738763022E-5 | 4.35511988925137E-4 | 3 | MAPK1;PDPK1;RPS6KA3 |
| RUNX3 regulates CDKN1A transcription | R-HSA-8941855 | http://reactome.org/PathwayBrowser/#/R-HSA-8941855 | 7 | 4 | 0.0762816260778925 | 52.4372670807453 | 4.5677205917638E-7 | 1.76999172930847E-5 | 4 | CDKN1A;SMAD4;TGFB1;TP53 |
| Regulation of IFNG signaling | R-HSA-877312 | http://reactome.org/PathwayBrowser/#/R-HSA-877312 | 14 | 6 | 0.152563252155785 | 39.327950310559 | 4.10798839389769E-9 | 3.89117789533087E-7 | 6 | JAK1;JAK2;PTPN6;SOCS1;SOCS3;STAT1 |
| Regulation of KIT signaling | R-HSA-1433559 | http://reactome.org/PathwayBrowser/#/R-HSA-1433559 | 16 | 4 | 0.174358002463754 | 22.941304347826 | 2.20153509069565E-5 | 4.21567650569023E-4 | 4 | FYN;PRKCA;PTPN6;SOCS1 |
| SMAD2/3 Phosphorylation Motif Mutants in Cancer | R-HSA-3304356 | http://reactome.org/PathwayBrowser/#/R-HSA-3304356 | 6 | 3 | 0.0653842509239079 | 45.8826086956521 | 2.46204738763022E-5 | 4.35511988925137E-4 | 3 | SMAD2;TGFB1;TGFBR1 |
| Signal attenuation | R-HSA-74749 | http://reactome.org/PathwayBrowser/#/R-HSA-74749 | 10 | 3 | 0.108973751539846 | 27.5295652173913 | 1.43083548345801E-4 | 0.0017807113133546 | 3 | INSR;IRS2;MAPK1 |
| Signaling by Leptin | R-HSA-2586552 | http://reactome.org/PathwayBrowser/#/R-HSA-2586552 | 11 | 5 | 0.119871126693831 | 41.7114624505928 | 6.17534916536044E-8 | 3.50965677564651E-6 | 5 | IRS2;JAK2;SOCS3;STAT3;STAT5A |
| The NLRP3 inflammasome | R-HSA-844456 | http://reactome.org/PathwayBrowser/#/R-HSA-844456 | 15 | 5 | 0.163460627309769 | 30.5884057971014 | 3.87642704380297E-7 | 1.65232702742101E-5 | 5 | NFKB1;PYCARD;RELA;TXN;TXNIP |
A
B
C
D
E
F
G
H
I
J
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
| Note: Edges are drawn between pathways based on their common genes, and the edge width is based on the number of those genes. | |||||||||
